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Conserved domains on  [gi|695766792|ref|WP_032689813|]
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MULTISPECIES: AraC family transcriptional regulator [Raoultella]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12033754)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlxA super family cl34854
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 152-274 5.44e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4977:

Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 101.00  E-value: 5.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 152 IDTFRPLAHHAPVIAeaahrfeRVRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL 231
Cdd:COG4977  199 SPLLVPLGHRDPRLA-------RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLL 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695766792 232 THG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQVARR 274
Cdd:COG4977  272 ETTdLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 1.56e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 88.30  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  16 RFRHPAQLPGVELYHAHISRYAFEPHTHEAFGIGAIELGAERFRYRGSQHVAPVNSIITMNPDELHTGEAATADGWRYRM 95
Cdd:COG2207    2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  96 VYLEPQMLEEVTGVRHWWFSEVVRQDPQRSQRLCQLIYGLWHTDDPLAQQGLLLDVIDTFRPLAHHAPVIAEAAHRFERV 175
Cdd:COG2207   82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 176 RDYLhdnyMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTR 254
Cdd:COG2207  162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                        250       260
                 ....*....|....*....|
gi 695766792 255 AFTRRYGITPVRYQKQVARR 274
Cdd:COG2207  238 AFKKRFGVTPSEYRKRLRAR 257
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 152-274 5.44e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 101.00  E-value: 5.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 152 IDTFRPLAHHAPVIAeaahrfeRVRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL 231
Cdd:COG4977  199 SPLLVPLGHRDPRLA-------RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLL 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695766792 232 THG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQVARR 274
Cdd:COG4977  272 ETTdLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
HTH_18 pfam12833
Helix-turn-helix domain;
192-270 5.03e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.56  E-value: 5.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  192 LAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTH--GMPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 695766792  270 Q 270
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
187-267 6.41e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 84.14  E-value: 6.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792   187 VSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPV 265
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 695766792   266 RY 267
Cdd:smart00342  82 EY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 1.56e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 88.30  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  16 RFRHPAQLPGVELYHAHISRYAFEPHTHEAFGIGAIELGAERFRYRGSQHVAPVNSIITMNPDELHTGEAATADGWRYRM 95
Cdd:COG2207    2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  96 VYLEPQMLEEVTGVRHWWFSEVVRQDPQRSQRLCQLIYGLWHTDDPLAQQGLLLDVIDTFRPLAHHAPVIAEAAHRFERV 175
Cdd:COG2207   82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 176 RDYLhdnyMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTR 254
Cdd:COG2207  162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                        250       260
                 ....*....|....*....|
gi 695766792 255 AFTRRYGITPVRYQKQVARR 274
Cdd:COG2207  238 AFKKRFGVTPSEYRKRLRAR 257
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 23-137 1.53e-19

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 82.10  E-value: 1.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792   23 LPGVELYHAHISRYAFEPHTHEAFGIGAIELGAERFRYRGSQHVAPVNSIITMNPDELHTGEAATADGWRYRMVYLEPQM 102
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 695766792  103 LEEVTgvRHWWFSEVVRQDPQRSQRLCQLIYGLWH 137
Cdd:pfam02311  81 LERIL--ADISILAGGPLPLLRDPELAALLRALFR 113
ftrA PRK09393
transcriptional activator FtrA; Provisional
 172-273 1.46e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 63.44  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 172 FERVRDYLHDNYmhavSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL-THGMPAAEVAAATGLTDQS 250
Cdd:PRK09393 224 IDWMRAHLAEPH----TVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEE 299

                         90       100
                 ....*....|....*....|...
gi 695766792 251 HLTRAFTRRYGITPVRYQKQVAR 273
Cdd:PRK09393 300 SLRHHFRRRAATSPAAYRKRFGR 322
 
Name Accession Description Interval E-value
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 152-274 5.44e-25

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 101.00  E-value: 5.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 152 IDTFRPLAHHAPVIAeaahrfeRVRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL 231
Cdd:COG4977  199 SPLLVPLGHRDPRLA-------RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLL 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695766792 232 THG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQVARR 274
Cdd:COG4977  272 ETTdLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRAR 315
HTH_18 pfam12833
Helix-turn-helix domain;
192-270 5.03e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.56  E-value: 5.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  192 LAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTH--GMPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 695766792  270 Q 270
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
187-267 6.41e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 84.14  E-value: 6.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792   187 VSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPV 265
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 695766792   266 RY 267
Cdd:smart00342  82 EY 83
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 156-274 1.03e-20

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 90.11  E-value: 1.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 156 RPLAhhAPVIAEAAHRFERVRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHGM 235
Cdd:COG2169   72 RPDL--APGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGL 149

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695766792 236 PAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQVARR 274
Cdd:COG2169  150 SVTDAAYAAGFGSLSRFYEAFKKLLGMTPSAYRRGGAGA 188
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
16-274 1.56e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 88.30  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  16 RFRHPAQLPGVELYHAHISRYAFEPHTHEAFGIGAIELGAERFRYRGSQHVAPVNSIITMNPDELHTGEAATADGWRYRM 95
Cdd:COG2207    2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  96 VYLEPQMLEEVTGVRHWWFSEVVRQDPQRSQRLCQLIYGLWHTDDPLAQQGLLLDVIDTFRPLAHHAPVIAEAAHRFERV 175
Cdd:COG2207   82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 176 RDYLhdnyMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTR 254
Cdd:COG2207  162 LLLL----LLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSR 237

                        250       260
                 ....*....|....*....|
gi 695766792 255 AFTRRYGITPVRYQKQVARR 274
Cdd:COG2207  238 AFKKRFGVTPSEYRKRLRAR 257
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 23-137 1.53e-19

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 82.10  E-value: 1.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792   23 LPGVELYHAHISRYAFEPHTHEAFGIGAIELGAERFRYRGSQHVAPVNSIITMNPDELHTGEAATADGWRYRMVYLEPQM 102
Cdd:pfam02311   1 NPGLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 695766792  103 LEEVTgvRHWWFSEVVRQDPQRSQRLCQLIYGLWH 137
Cdd:pfam02311  81 LERIL--ADISILAGGPLPLLRDPELAALLRALFR 113
ftrA PRK09393
transcriptional activator FtrA; Provisional
 172-273 1.46e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 63.44  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 172 FERVRDYLHDNYmhavSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL-THGMPAAEVAAATGLTDQS 250
Cdd:PRK09393 224 IDWMRAHLAEPH----TVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQIAERAGFGSEE 299

                         90       100
                 ....*....|....*....|...
gi 695766792 251 HLTRAFTRRYGITPVRYQKQVAR 273
Cdd:PRK09393 300 SLRHHFRRRAATSPAAYRKRFGR 322
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
155-269 2.38e-10

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 60.19  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 155 FRPLAHHAPVIAEA-AHRFERV----RDYLHDNymhAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKA 229
Cdd:PRK15435  66 FRPCKRCQPDKANPqQHRLDKIthacRLLEQET---PVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLRE 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695766792 230 FLTHGMPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQK 269
Cdd:PRK15435 143 ALAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFRH 182
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 179-219 8.41e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 44.84  E-value: 8.41e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 695766792  179 LHDNYMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQML 219
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYR 41
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
81-270 2.51e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 47.66  E-value: 2.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792  81 HTGEAATADGWRYRMVYLEPqmleevtgvRHWW---------FSEVVR---QDPQRSQRLCQLIYGLWHT---DDPLAQQ 145
Cdd:PRK10572  86 HYGRHPDSDEWYHQWVYFRP---------RAYWadwlnwpsiFAGVGRlriPDEALQPEFSDLFGQIEQAgqsEGRYSEL 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 146 -------GLLLDVIdTFRPLAHHAPViaeaAHRFERVRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKahfhvtpHQM 218
Cdd:PRK10572 157 lamnlleRLLLRCM-EAIPESLHPPM----DPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFR-------QQL 224

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 219 LMAIRLWR-------AKAFL-THGMPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQ 270
Cdd:PRK10572 225 GISVLRWRedqrisrAKLLLqTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
171-264 2.97e-06

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 47.36  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 171 RFERVRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQ 249
Cdd:PRK13503 172 RLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSdASVTDIAYRCGFGDS 251

                         90
                 ....*....|....*
gi 695766792 250 SHLTRAFTRRYGITP 264
Cdd:PRK13503 252 NHFSTLFRREFSWSP 266
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 142-273 1.23e-04

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 42.61  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 142 LAQQGLLLDVIDTFRPLAHHAPVIAEAAHRFERVR--DYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHfHVTPHQML 219
Cdd:PRK09978 112 LRKRALIFALLSVFLEDEHFIPLLLNVLQPNMRTRvcTVINNNIAHEWTLARIASELLMSPSLLKKKLREE-ETSYSQLL 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695766792 220 MAIRLWRA-KAFLTHGMPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQVAR 273
Cdd:PRK09978 191 TECRMQRAlQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQERSAQ 245
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
175-268 2.66e-04

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 40.09  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 175 VRDYLHDNYMHAVSLDELAQVAALSPYHFQRQFKAHfhvTPHQMLMAIRLWR----AKAFLTHGMPAAEVAAATGLTDQS 250
Cdd:PRK11511  14 ILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKE---TGHSLGQYIRSRKmteiAQKLKESNEPILYLAERYGFESQQ 90

                         90
                 ....*....|....*...
gi 695766792 251 HLTRAFTRRYGITPVRYQ 268
Cdd:PRK11511  91 TLTRTFKNYFDVPPHKYR 108
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
189-268 2.96e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 41.58  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 189 LDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPVRY 267
Cdd:PRK13502 195 LDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSpLMISEISMQCGFEDSNYFSVVFTRETGMTPSQW 274


                 .
gi 695766792 268 Q 268
Cdd:PRK13502 275 R 275
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
188-268 1.36e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 39.70  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 188 SLDELAQVAALSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFLTHG-MPAAEVAAATGLTDQSHLTRAFTRRYGITPVR 266
Cdd:PRK13500 224 ALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSrLLISDISTECGFEDSNYFSVVFTRETGMTPSQ 303


                 ..
gi 695766792 267 YQ 268
Cdd:PRK13500 304 WR 305
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 231-269 1.44e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.59  E-value: 1.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 695766792  231 LTHGMPAAEVAAATGLtDQSHLTRAFTRRYGITPVRYQK 269
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
198-274 2.39e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 38.73  E-value: 2.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695766792 198 LSPYHFQRQFKAHFHVTPHQMLMAIRLWRAKAFL-THGMPAAEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQVARR 274
Cdd:PRK13501 204 LVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLrGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRFIRS 281
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
175-269 2.63e-03

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 38.45  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695766792 175 VRDYLH--DNYM-HAVSLDELAQVAALSPYHFQRQFKahfHVTPHQMLMAIRLWR----AKAFLTHGMPAAEVAAATGLT 247
Cdd:PRK15121   7 IRDLLIwlEGHLdQPLSLDNVAAKAGYSKWHLQRMFK---DVTGHAIGAYIRARRlskaAVALRLTSRPILDIALQYRFD 83

                         90       100
                 ....*....|....*....|..
gi 695766792 248 DQSHLTRAFTRRYGITPVRYQK 269
Cdd:PRK15121  84 SQQTFTRAFKKQFAQTPALYRR 105
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 238-270 3.93e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 38.09  E-value: 3.93e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 695766792 238 AEVAAATGLTDQSHLTRAFTRRYGITPVRYQKQ 270
Cdd:PRK09685 268 TSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRK 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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