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Conserved domains on  [gi|695765408|ref|WP_032688441|]
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MULTISPECIES: AraC family transcriptional regulator [Raoultella]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 13303805)

AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.72e-30

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.18  E-value: 1.72e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408   185 PLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 695765408   265 SEYR 268
Cdd:smart00342  81 SEYR 84
PRK13503 super family cl32884
HTH-type transcriptional activator RhaS;
85-268 1.35e-14

HTH-type transcriptional activator RhaS;


The actual alignment was detected with superfamily member PRK13503:

Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 72.02  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408  85 STLSILFGRQKLGFCIQHW--DGKRLRTEKQSVARLGPRVGSYLL--LALNEIC-LQpdpvtarlVVSALLSHCLEQlvG 159
Cdd:PRK13503  96 AGLNQLLPQEQDGQYPSHWrvNQSVLQQVRQLVAQMEQQEESNDLeaIASREILfMQ--------LLVLLRKSSLQE--N 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 160 LEMRVSRSRDLFmavqDYLEENLSQPLTRESVAKRFHITPNYL-SHIFQKSGSVGFNeYLTRVRLEQAKKLLRGYDLKVK 238
Cdd:PRK13503 166 GENSDARLNQLL----AWLEDHFAEEVNWEALADQFSLSLRTLhRQLKQQTGLTPQR-YLNRLRLLKARHLLRHSDASVT 240

                        170       180       190
                 ....*....|....*....|....*....|
gi 695765408 239 EIAHNCGFVDSNYFCRVFKRYTERSPSEYR 268
Cdd:PRK13503 241 DIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.72e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.18  E-value: 1.72e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408   185 PLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 695765408   265 SEYR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
125-274 2.09e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.40  E-value: 2.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 125 YLLLALNEICLQPDPVTARLVVSALLSHCLEQLVGLEMRVSRSRDLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSH 204
Cdd:COG2207  108 LLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSR 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 205 IFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRHCRSA 274
Cdd:COG2207  188 LFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRAR 257
HTH_18 pfam12833
Helix-turn-helix domain;
191-269 9.47e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 86.49  E-value: 9.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408  191 VAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGY-DLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRR 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
176-272 1.76e-16

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 77.32  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 176 DYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSgsVGFNEYLTR--VRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFC 253
Cdd:PRK10572 190 QYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQ--LGISVLRWRedQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFS 267

                         90
                 ....*....|....*....
gi 695765408 254 RVFKRYTERSPSEYRRHCR 272
Cdd:PRK10572 268 RVFKKCTGASPSEFRARCE 286
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
85-268 1.35e-14

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 72.02  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408  85 STLSILFGRQKLGFCIQHW--DGKRLRTEKQSVARLGPRVGSYLL--LALNEIC-LQpdpvtarlVVSALLSHCLEQlvG 159
Cdd:PRK13503  96 AGLNQLLPQEQDGQYPSHWrvNQSVLQQVRQLVAQMEQQEESNDLeaIASREILfMQ--------LLVLLRKSSLQE--N 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 160 LEMRVSRSRDLFmavqDYLEENLSQPLTRESVAKRFHITPNYL-SHIFQKSGSVGFNeYLTRVRLEQAKKLLRGYDLKVK 238
Cdd:PRK13503 166 GENSDARLNQLL----AWLEDHFAEEVNWEALADQFSLSLRTLhRQLKQQTGLTPQR-YLNRLRLLKARHLLRHSDASVT 240

                        170       180       190
                 ....*....|....*....|....*....|
gi 695765408 239 EIAHNCGFVDSNYFCRVFKRYTERSPSEYR 268
Cdd:PRK13503 241 DIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.72e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.18  E-value: 1.72e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408   185 PLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 695765408   265 SEYR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
125-274 2.09e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.40  E-value: 2.09e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 125 YLLLALNEICLQPDPVTARLVVSALLSHCLEQLVGLEMRVSRSRDLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSH 204
Cdd:COG2207  108 LLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSR 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 205 IFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRHCRSA 274
Cdd:COG2207  188 LFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRAR 257
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 156-275 1.02e-24

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 100.62  E-value: 1.02e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 156 QLVGLEMRVSRSRDLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDL 235
Cdd:COG4977  197 QFSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDL 276

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695765408 236 KVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRHCRSAQ 275
Cdd:COG4977  277 SIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFRARA 316
HTH_18 pfam12833
Helix-turn-helix domain;
191-269 9.47e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 86.49  E-value: 9.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408  191 VAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGY-DLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRR 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
176-272 1.76e-16

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 77.32  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 176 DYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSgsVGFNEYLTR--VRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFC 253
Cdd:PRK10572 190 QYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQ--LGISVLRWRedQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFS 267

                         90
                 ....*....|....*....
gi 695765408 254 RVFKRYTERSPSEYRRHCR 272
Cdd:PRK10572 268 RVFKKCTGASPSEFRARCE 286
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
85-268 1.35e-14

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 72.02  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408  85 STLSILFGRQKLGFCIQHW--DGKRLRTEKQSVARLGPRVGSYLL--LALNEIC-LQpdpvtarlVVSALLSHCLEQlvG 159
Cdd:PRK13503  96 AGLNQLLPQEQDGQYPSHWrvNQSVLQQVRQLVAQMEQQEESNDLeaIASREILfMQ--------LLVLLRKSSLQE--N 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 160 LEMRVSRSRDLFmavqDYLEENLSQPLTRESVAKRFHITPNYL-SHIFQKSGSVGFNeYLTRVRLEQAKKLLRGYDLKVK 238
Cdd:PRK13503 166 GENSDARLNQLL----AWLEDHFAEEVNWEALADQFSLSLRTLhRQLKQQTGLTPQR-YLNRLRLLKARHLLRHSDASVT 240

                        170       180       190
                 ....*....|....*....|....*....|
gi 695765408 239 EIAHNCGFVDSNYFCRVFKRYTERSPSEYR 268
Cdd:PRK13503 241 DIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 176-270 5.27e-14

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 70.85  E-value: 5.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 176 DYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGyDLKVKEIAHNCGFVDSNYFCRV 255
Cdd:COG2169   91 RLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQT-GLSVTDAAYAAGFGSLSRFYEA 169

                         90
                 ....*....|....*
gi 695765408 256 FKRYTERSPSEYRRH 270
Cdd:COG2169  170 FKKLLGMTPSAYRRG 184
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
169-269 1.24e-13

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 69.55  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 169 DLFMAVqdyLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVD 248
Cdd:PRK13501 179 DLIMSA---LQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFED 255

                         90       100
                 ....*....|....*....|.
gi 695765408 249 SNYFCRVFKRYTERSPSEYRR 269
Cdd:PRK13501 256 SNYFSAVFTREAGMTPRDYRQ 276
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 146-272 4.15e-12

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 65.05  E-value: 4.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 146 VSALLSHCLEQLVGLEMRVSRSrdlFMAVQDYLEENLSQP-LTRESVAKRFHITPNYLSHIFQKSGSVgFNEYLTRVRLE 224
Cdd:PRK09685 177 LIALLRPALHQRESVQPRRERQ---FQKVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQGLV-VAQYIRNRRLD 252

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695765408 225 QAKKLLRGY--DLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRHCR 272
Cdd:PRK09685 253 RCADDLRPAadDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
PRK10371 PRK10371
transcriptional regulator MelR;
176-277 6.96e-12

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 64.46  E-value: 6.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 176 DYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRV 255
Cdd:PRK10371 198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYST 277

                         90       100
                 ....*....|....*....|..
gi 695765408 256 FKRYTERSPSEYRRHCRSAQQG 277
Cdd:PRK10371 278 FGKYVGMSPQQYRKLSQQRRQT 299
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
178-268 2.30e-11

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 62.76  E-value: 2.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 178 LEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFK 257
Cdd:PRK13502 185 LANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFT 264

                         90
                 ....*....|.
gi 695765408 258 RYTERSPSEYR 268
Cdd:PRK13502 265 RETGMTPSQWR 275
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
169-268 3.66e-11

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 58.78  E-value: 3.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 169 DLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVD 248
Cdd:PRK10219   5 KIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVS 84

                         90       100
                 ....*....|....*....|
gi 695765408 249 SNYFCRVFKRYTERSPSEYR 268
Cdd:PRK10219  85 QQTFSRVFRRQFDRTPSDYR 104
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 143-276 1.97e-10

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 59.94  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 143 RLVVSALLSHCLE--QLVGLEMRVSRSrDLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSvGFNEYLTR 220
Cdd:PRK09978 115 RALIFALLSVFLEdeHFIPLLLNVLQP-NMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEET-SYSQLLTE 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 695765408 221 VRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRhcRSAQQ 276
Cdd:PRK09978 193 CRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQE--RSAQG 246
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
178-268 2.35e-09

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 57.03  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 178 LEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFK 257
Cdd:PRK13500 215 LAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFT 294

                         90
                 ....*....|.
gi 695765408 258 RYTERSPSEYR 268
Cdd:PRK13500 295 RETGMTPSQWR 305
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 234-269 4.60e-09

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 51.00  E-value: 4.60e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 695765408  234 DLKVKEIAHNCGFvDSNYFCRVFKRYTERSPSEYRR 269
Cdd:pfam00165   8 NLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
173-268 1.54e-07

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 49.33  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 173 AVQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYF 252
Cdd:PRK11511  13 SILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTL 92

                         90
                 ....*....|....*.
gi 695765408 253 CRVFKRYTERSPSEYR 268
Cdd:PRK11511  93 TRTFKNYFDVPPHKYR 108
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 208-275 8.52e-07

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 49.29  E-value: 8.52e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695765408 208 KSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRHCRSAQ 275
Cdd:PRK15186 219 KQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSR 286
ftrA PRK09393
transcriptional activator FtrA; Provisional
 165-269 1.31e-06

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 48.81  E-value: 1.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 165 SRSRDLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNC 244
Cdd:PRK09393 214 SRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERA 293

                         90       100
                 ....*....|....*....|....*
gi 695765408 245 GFVDSNYFCRVFKRYTERSPSEYRR 269
Cdd:PRK09393 294 GFGSEESLRHHFRRRAATSPAAYRK 318
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 199-267 2.75e-05

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 44.60  E-value: 2.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695765408 199 PNYLSHIFQKSGSV---------GFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEY 267
Cdd:PRK15185 226 TDVADHIFMSTSTLkrklaeegtSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 174-273 1.32e-04

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 42.38  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 174 VQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVgFNEYLTRVRLEQAKKLLRgYDLKVKEIAHNCGFVDSNYFC 253
Cdd:PRK09940 139 VRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTT-FSQILLDARMQHAKNLIR-VEGSVNKIAEQCGYASTSYFI 216

                         90       100
                 ....*....|....*....|....
gi 695765408 254 RVFKRYTERSP----SEYRrhCRS 273
Cdd:PRK09940 217 YAFRKHFGNSPkrvsKEYR--CQR 238
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 216-270 3.26e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 41.28  E-value: 3.26e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695765408 216 EYLTR----------------VRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRRH 270
Cdd:PRK10296 203 EYLTRatrryygktpmqiineIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 178-219 1.37e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.59  E-value: 1.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 695765408  178 LEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLT 219
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
168-265 2.15e-03

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 39.13  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765408 168 RDLFMAVQDYLEENLSQPLTRESVAKRFHITPNYLSHIFQKSGSVGFNEYLTRVRLEQAKK-LLRGYDLK--VKEIAHNC 244
Cdd:PRK10130 239 RRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRReLISPWSQSttVKDAAMQW 318

                         90       100
                 ....*....|....*....|.
gi 695765408 245 GFVDSNYFCRVFKRYTERSPS 265
Cdd:PRK10130 319 GFWHLGQFATDYQQLFAEKPS 339
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 212-269 3.13e-03

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 38.48  E-value: 3.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695765408 212 VGFNEYLTRVRLEQAKKLLRGYDLKVKEIAHNCGFVDSNYFCRVFKRYTERSPSEYRR 269
Cdd:PRK15044 234 VSFSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITPLSFMR 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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