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Conserved domains on  [gi|695765344|ref|WP_032688377|]
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MULTISPECIES: multidrug efflux MFS transporter MdtH [Raoultella]

Protein Classification

MFS transporter( domain architecture ID 11485445)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


:

Pssm-ID: 183255  Cd Length: 400  Bit Score: 733.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   1 MSRVSQARSLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  81 TGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 161 YDFRLVCSVGAALFVACAAFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 241 SPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 321 LGASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGKALNQPELPWLMLGIIGLFTFLALWWQFSQKRSTSGMLEP 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
 
Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 733.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   1 MSRVSQARSLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  81 TGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 161 YDFRLVCSVGAALFVACAAFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 241 SPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 321 LGASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGKALNQPELPWLMLGIIGLFTFLALWWQFSQKRSTSGMLEP 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-386 4.67e-84

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 261.01  E-value: 4.67e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  13 YFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAA 92
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  93 MAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAA 172
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 173 LFVACAAFNAWYLPAWKLSTV---KTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG-SPTAVKWM 248
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRaaeKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlGESLLGLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 249 YAIEAAISLTLLYPIARWSEqRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADA 328
Cdd:cd17329  242 LALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695765344 329 RARGSYMGFSRLGLAFGGAFGYAGGGWLFDagkaLNQPELPWLMLGIIGLFTFLALWW 386
Cdd:cd17329  321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLD----LLGPGLPWLILAALGLIAAALLLG 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-337 1.34e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.08  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   1 MSRVSQARSLGKYFLLVDNMLVVLGFFVVFPLISIrFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  81 TGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ 160
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 161 Y-DFRLVCSVGAALFVACAAFNAWYLPAwKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIA 239
Cdd:COG2814  160 LfGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 240 GSPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARE 319
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330
                 ....*....|....*...
gi 695765344 320 TLGASLADARARGSYMGF 337
Cdd:COG2814  319 ALVAELAPPEARGRASGL 336
MFS_1 pfam07690
Major Facilitator Superfamily;
20-337 3.10e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 3.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  100 WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-QYDFRLVCSVGAALFVACA 178
Cdd:pfam07690  86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  179 AFNAWYLPAWKLSTVKTPVREGLG-----RVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEA 253
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSlivawKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  254 AISLTLLYPIARWSE--QRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARAR 331
Cdd:pfam07690 246 LLGAIGRLLLGRLSDrlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325


                  ....*.
gi 695765344  332 GSYMGF 337
Cdd:pfam07690 326 GTASGL 331
2_A_01_02 TIGR00880
Multidrug resistance protein;
57-186 6.12e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 56.89  E-value: 6.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   57 LVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRF 136
Cdd:TIGR00880   9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 695765344  137 FSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACAAFNAWYLP 186
Cdd:TIGR00880  89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
 
Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 733.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   1 MSRVSQARSLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  81 TGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 161 YDFRLVCSVGAALFVACAAFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 241 SPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 321 LGASLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGKALNQPELPWLMLGIIGLFTFLALWWQFSQKRSTSGMLEP 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-386 4.67e-84

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 261.01  E-value: 4.67e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  13 YFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAA 92
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  93 MAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAA 172
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 173 LFVACAAFNAWYLPAWKLSTV---KTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG-SPTAVKWM 248
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRaaeKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlGESLLGLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 249 YAIEAAISLTLLYPIARWSEqRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADA 328
Cdd:cd17329  242 LALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695765344 329 RARGSYMGFSRLGLAFGGAFGYAGGGWLFDagkaLNQPELPWLMLGIIGLFTFLALWW 386
Cdd:cd17329  321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLD----LLGPGLPWLILAALGLIAAALLLG 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-337 1.34e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.08  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   1 MSRVSQARSLGKYFLLVDNMLVVLGFFVVFPLISIrFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  81 TGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ 160
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 161 Y-DFRLVCSVGAALFVACAAFNAWYLPAwKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIA 239
Cdd:COG2814  160 LfGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 240 GSPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARE 319
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330
                 ....*....|....*...
gi 695765344 320 TLGASLADARARGSYMGF 337
Cdd:COG2814  319 ALVAELAPPEARGRASGL 336
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 15-339 3.38e-30

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 119.60  E-value: 3.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  15 LLVDNMLVVLGFFVVFPLISIrFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMA 94
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  95 VAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAAL 173
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 174 FVACAAFNAWYLP-----AWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG-SPTAVKW 247
Cdd:cd17325  160 ALLALVLALLLLPeprppPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 248 MYAIEAAISLTLLYPIARWSEqRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLAD 327
Cdd:cd17325  240 LFGAQGLASALSQPPAGKLSD-RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318

                        330
                 ....*....|..
gi 695765344 328 ARARGSYMGFSR 339
Cdd:cd17325  319 PEGRGTAMGLFN 330
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-385 1.13e-29

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 118.30  E-value: 1.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  15 LLVDNMLVVLGFFVVFPLISIrFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMA 94
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  95 VAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQY---DFRLVCSVGA 171
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 172 ALFVACAAFNAWYLPAWKLSTV-------KTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTA 244
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARakneeasSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 245 V-KWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGA 323
Cdd:cd06174  240 VaGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695765344 324 SLADARARGSYMGFSRLGLAFGGAFGYAGGGWLFDAGkalNQPELPWLMLGIIGLFTFLALW 385
Cdd:cd06174  320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT---FGLTGAFLVLAVLLLLAAILLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
20-337 3.10e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 3.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:pfam07690   6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  100 WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-QYDFRLVCSVGAALFVACA 178
Cdd:pfam07690  86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILSLLAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  179 AFNAWYLPAWKLSTVKTPVREGLG-----RVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEA 253
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSlivawKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  254 AISLTLLYPIARWSE--QRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARAR 331
Cdd:pfam07690 246 LLGAIGRLLLGRLSDrlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325


                  ....*.
gi 695765344  332 GSYMGF 337
Cdd:pfam07690 326 GTASGL 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-185 5.61e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 84.55  E-value: 5.61e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:cd17325  209 FVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 100 WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFVACA 178
Cdd:cd17325  289 WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAA 368


                 ....*..
gi 695765344 179 AFNAWYL 185
Cdd:cd17325  369 VLFLLLR 375
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 37-387 2.07e-17

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 83.05  E-value: 2.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  37 FVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAH-----EPWVLWLSCILSGL 111
Cdd:cd06173   25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 112 GGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACAAFNAWYLPAWKLS 191
Cdd:cd06173  105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 192 TVKTP-------VREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG-SPTAVKWMYAIEAAISLTLLYPI 263
Cdd:cd06173  185 APGESsslllrdLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGgGAAGYGLLLAAFGVGALLGALLL 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 264 ARWSEqRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARGSYMGFSRLGLA 343
Cdd:cd06173  265 GRLSK-RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 695765344 344 FGGAFGYAGGGWLFDAGKAlnqpELPWLMLGIIGLFTFLALWWQ 387
Cdd:cd06173  344 GAMPLGALLAGLLADALGL----SAVFLLAGALLLLAALLLLLL 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-395 2.25e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 79.92  E-value: 2.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:COG2223   14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 100 WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFVACA 178
Cdd:COG2223   94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 179 AFNAWYL---PAWKLSTVKTPVREgLGRVLRDKRF----VTYVLTLTGYYMLAVQvmlmLPIMVNDIAGSPTAVKWMYAI 251
Cdd:COG2223  174 VLAWLFLrdpPAGAAAAAKASLRD-QLEALRDPRFwllsLLYFGTFGSFIGFSSW----LPPYLVDQFGLSAATAGLLAA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 252 EAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTS-NLQQLFTLICIFYIGSIVAEPARETLGASLADARA 330
Cdd:COG2223  249 LFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN 328

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695765344 331 RGSYMGFSRLGLAFGGAFGYAGGGWLFDagkALNQPELPWLMLGIIGLFTFLALWWQFSQKRSTS 395
Cdd:COG2223  329 AGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-386 2.73e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.53  E-value: 2.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:COG2271   19 YFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 100 WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-QYDFRLVCSVGAALFVACA 178
Cdd:COG2271   99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPGLLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 179 AFNAWYLpawklstvktpvreglgrvlrdkrFVTYVLTLTGYYMLAVQvmlMLPIMVNDIAGSPTAVKWMYAIEAAISLT 258
Cdd:COG2271  179 LLRFWLL------------------------ALAYFLVYFALYGFLTW---LPTYLVEVRGLSLAQAGLLLSLPFLAGIV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 259 LLYPIARWSEQRFRLEHRLMA-GLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARGSYMGF 337
Cdd:COG2271  232 GSLLGGWLSDRLGRRRKLVLAiGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 695765344 338 SRLGLAFGGAFGYAGGGWLFDAGkalnQPELPWLMLGIIGLFTFLALWW 386
Cdd:COG2271  312 VNTFGFLGGALGPLLVGYLLDAT----GYQAAFLLLAALALLAALLALL 356
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 62-336 4.27e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 79.15  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  62 LGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILM 141
Cdd:cd17474   50 LMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 142 MQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACAAFNAWYLPAWKLSTVKTPV--REGLGRVLRDKRFVTYVLTLTG 219
Cdd:cd17474  130 AALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAtkLRDLKKALRGRGLLTFLVSAFL 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 220 YYMLAVQVMLMLPIMVNDIAG-SPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQ 298
Cdd:cd17474  210 YFFLYFAFLTYLPFLLELLYGiSPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLA 289

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 695765344 299 QLFTLICIFYIGSIVAEPARETLGASLADARARGSYMG 336
Cdd:cd17474  290 LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 15-303 1.80e-15

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 77.20  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  15 LLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADR-FGAKPMIVTGMLMRAGGFAAM 93
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  94 AVAHEPWVLWL-SCILSGLGGTLFdpPR----AALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-QYDFRLVC 167
Cdd:cd17471   81 AFLRNYWVLLLvGVVLLSLGAAAF--PQlfalAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLdVLGFTGLF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 168 SVGAALFVACAAFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPI-MVNDIAGSPTAVK 246
Cdd:cd17471  159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLyVTNELGGSESWVG 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695765344 247 WMYAIEAAISLTLLYPIARWSEqRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTL 303
Cdd:cd17471  239 LLFGLAAALEIPIMLLAGLLAK-RFGKRRLLLAGFLAGVLFYLGLALATSLWQLIAL 294
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 24-336 4.70e-15

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 76.10  E-value: 4.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  24 LGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLW 103
Cdd:cd17472   10 LGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 104 LSCILSGLG---GTLFdppraALVVKLVRPHQRGRFFSILmmqdsaGAVIG-----ALLGSWLLQ--YDFRLVCSVGAAL 173
Cdd:cd17472   90 LGRALQGSGaisSVVM-----ALLADLTREENRTKAMALI------GASIGiafaiSMVLGPLLAahLGVSGLFLITAIL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 174 FVACAAFNAWYLPAWKLS-TVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIE 252
Cdd:cd17472  159 SLVSLLILLFFVPDPPKIvQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 253 AAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTS-NLQQLFTLICIFYIGSIVAEPARETLGASLADARAR 331
Cdd:cd17472  239 ILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318


                 ....*
gi 695765344 332 GSYMG 336
Cdd:cd17472  319 GTAMG 323
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 25-337 5.53e-14

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 72.58  E-value: 5.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  25 GFFVVFPLisirFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGA-KPMIVTGMLMRAGGFAAMAVAHEPWVLW 103
Cdd:cd17370   17 MARSILPL----FLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSALAKPLLALAGSWQLVL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 104 LSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQY---DFRLVCSVGAALFVACAAF 180
Cdd:cd17370   93 LLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLlggNYRTIFLLAAIPALLALLI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 181 NAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLpIMVNDIAGSPTAVKWMYAIEAAISLTLL 260
Cdd:cd17370  173 LLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI-LRAQELGLSAALIPLLYALFNLVYALAA 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695765344 261 YPIARWSEqRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARGSYMGF 337
Cdd:cd17370  252 YPAGRLSD-RIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL 327
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-337 5.85e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 66.85  E-value: 5.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  24 LGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAK-----PMIVTGMLMRAGGFAAMAVAHE 98
Cdd:COG2211   24 LAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTAPD 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  99 P------WVLWLSCILSGLGGTLFDPPRAALVVKLVR-PHQRGRFFSILMMQDSAGAVIGALLGSWLLQY-------DFR 164
Cdd:COG2211  104 LsptgklIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 165 LVCSVGAALFVACAAFNAWYLP-AWKLSTVKTPVREGLGRVLRDKRFVTYVL-TLTGYYMLAVQVMLMLPIMVNDIAGSP 242
Cdd:COG2211  184 LTALIFAVLGLLAFLLTFFGTKeRPVPEEEKVSLKESLKALLKNRPFLLLLLaYLLFFLALALVAALLLYYFKYVLGLSA 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 243 TAVKWMYAIEAAISLTLLYPIARWSeQRFRLEHRLMAGLLVMTIAMLPIGL--TSNLQQLFTLICIFYIGSIVAEPARET 320
Cdd:COG2211  264 ALVGLLLALYFLAALLGAPLWPRLA-KRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWA 342

                        330       340
                 ....*....|....*....|....
gi 695765344 321 LGASLADA-------RARGSYMGF 337
Cdd:COG2211  343 MLADVVDYdewktgrRREGLYFGI 366
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 24-338 1.06e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 65.68  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  24 LGFFVVFPLIS--IRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWV 101
Cdd:cd17330   10 LGFGIVFPVLPfyVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 102 LWLSCILSGLGGTLFdPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFVACAAF 180
Cdd:cd17330   90 LFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTpYGYALPFLVAAALALLNLVL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 181 NAWYLPAwklstvktpvregLGRVLrdkrfVTYVLTLTGYYMLAVQVMLMLPIMVNDiagSPTAVKWMYAIEAAISLTLL 260
Cdd:cd17330  169 VLFFLPP-------------LRRLL-----LVYFLIALAFAGLESVFSLFLKDRFGF---SPSQIGLLLALVGIAGILAQ 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695765344 261 YPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARGSYMGFS 338
Cdd:cd17330  228 LLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGII 305
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-336 3.31e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 64.15  E-value: 3.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  15 LLVDNMLVVLGFFVVFPLISIrFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMA 94
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPL-YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  95 VAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAAL 173
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVLFIVAAVL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 174 FVACAAFnAWYLPAWKLSTVKTPVREGLG-RVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSptaVKWMYAIE 252
Cdd:cd17489  160 ALLALLL-VFLVKDPPPVAAEEAEAGTRAfRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTV 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 253 AAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARG 332
Cdd:cd17489  236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315


                 ....
gi 695765344 333 SYMG 336
Cdd:cd17489  316 AANG 319
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
40-310 9.34e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 62.95  E-value: 9.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  40 QMGWAALMVGIALGLrqlvqqgLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPP 119
Cdd:COG0738   44 QAGLLLFAFFLGYLL-------ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 120 RAALVVKLVrPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDF-----RLVCSVGAALFVACAAFNAWYLPAWKL-STV 193
Cdd:COG0738  117 ANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslswhLPYLILAVLLLLLALLFLRSKLPEIEEeEEE 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 194 KTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISLTLLYPIARWSEQRFRL 273
Cdd:COG0738  196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 695765344 274 EHRLMAGLLVMTIAMLPIGLTSNLqqLFTLICIFYIG 310
Cdd:COG0738  276 VRLLRLSALLAAVGLLLALLAPGP--WLALIGLALVG 310
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 19-337 1.22e-10

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 62.67  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  19 NMLVVLGFFVVFPLISIRFvdqmGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHE 98
Cdd:cd17355   15 SWGIRYYFGVFIIPIIAEF----GWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  99 PWVLWLSCILSGLGGTL-FDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-QYDFRLVCSVGAALFVA 176
Cdd:cd17355   91 LWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIeAFGWRTALLVLALLALL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 177 CAAFNAWYLPAWKLSTVKTPV--------REGLGRVLRDKRFVTYVLT--LTGYYMLAVQVmlMLPIMVNDIAGSPTAVK 246
Cdd:cd17355  171 VLVPVLLLLRRRPADLALRAYddaspaspGSTLKEALRSASFWLLALAffLCGFAVVGLIV--HLVPYLADRGISPAAAA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 247 WMYAIEAAISL--TLLYpiaRWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAE-PARETLGA 323
Cdd:cd17355  249 VALALIGLFNIvgRLLS---GWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATvPLTAALAA 325

                        330
                 ....*....|....
gi 695765344 324 SLADARARGSYMGF 337
Cdd:cd17355  326 RYFGARSYGTLFGL 339
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-307 1.90e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 61.80  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  67 GAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSA 146
Cdd:cd17324   55 GPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 147 GAVIGALLGSWLLQY-DFRLVCSVGAALFVACAAFNAWYLPAWKLST-VKTPVREGLGRVLRDKR-FVTYVLTLTGYYML 223
Cdd:cd17324  135 GLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKpGSLGLLSSLLLLLRNPRlRLAYLITFLLFGGF 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 224 AVQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISLTLLYPIARWSEQRFRleHRLMAGLLVMTIAMLPIGLTSNLQQLFTL 303
Cdd:cd17324  215 FALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR--RALLIALLLLAAALLLLTLLGPSPLLLLV 292


                 ....
gi 695765344 304 ICIF 307
Cdd:cd17324  293 GLVL 296
2_A_01_02 TIGR00880
Multidrug resistance protein;
57-186 6.12e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 56.89  E-value: 6.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   57 LVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRF 136
Cdd:TIGR00880   9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 695765344  137 FSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACAAFNAWYLP 186
Cdd:TIGR00880  89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLL 138
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
39-287 8.06e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 59.89  E-value: 8.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  39 DQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDP 118
Cdd:COG2807   46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 119 PRAALvVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFVACAAFNAWYLPAWKLSTVKTPV 197
Cdd:COG2807  126 LLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 198 REGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISLTLLYPIARWSEqRFRLEHRL 277
Cdd:COG2807  205 AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDRRPL 283

                        250
                 ....*....|
gi 695765344 278 MAGLLVMTIA 287
Cdd:COG2807  284 LLLLGLLGLA 293
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 19-292 3.30e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.51  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  19 NMLVVLGFFVVFPLISIrFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHE 98
Cdd:COG0477   23 TFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  99 PWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACA 178
Cdd:COG0477  102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLA 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 179 AFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISLT 258
Cdd:COG0477  182 LVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAA 261

                        250       260       270
                 ....*....|....*....|....*....|....
gi 695765344 259 LLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIG 292
Cdd:COG0477  262 LLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 8-158 9.25e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 56.78  E-value: 9.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   8 RSLGKYFLLvdnMLVVLGFFVV----FPLISIRFVdQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGM 83
Cdd:cd17370  196 KKLPKAFWL---YLLAVALFALgnfsFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695765344  84 LMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILmmqdSAGAVIGALLGSWL 158
Cdd:cd17370  272 LSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF----NTVVGIGWLLASLI 342
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 40-310 1.77e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 55.66  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  40 QMGWAALMVGIALGLrqlvqqglgIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPP 119
Cdd:cd17320   37 QLTLSAYLLGFALGQ---------LLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 120 RAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-----QYDFRLVCSVGAALFVACAAFNAWYLPAWKLSTVK 194
Cdd:cd17320  108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLlffgwRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 195 TPVREGLGRVLRDKRFVTYVLTLTGYY-MLAVQVMLMLPIMVNDIAGSPTAVKWMYAIeAAISLTLLYPIARWSEQRFRL 273
Cdd:cd17320  188 SSLLRAYKRVLKNRRFLGYALALGLSFaGLFAYLAAAPFIYIEQLGLSPAQFGLLFAL-NAIALILGSLLNGRLVRRFGP 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 695765344 274 EHRLMAGLLVMTIAMLPIGLTSNLQQ-----LFTLICIFYIG 310
Cdd:cd17320  267 RRLLRLGLLLLLAAALVLLLAALLGGlslwpLVAPLFLIFFG 308
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 64-161 5.21e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 54.49  E-value: 5.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  64 IFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQ 143
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAV 128

                         90
                 ....*....|....*...
gi 695765344 144 DSAGAVIGALLGSWLLQY 161
Cdd:cd17321  129 VGIGAALGPLLGGLLLEL 146
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 70-310 6.69e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 54.12  E-value: 6.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  70 ADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAV 149
Cdd:cd17503   55 ADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 150 IGALLGSWLLQYD-----FRLVCSVGAALFVACAAFNAwylpawklstvktpvreglgRVLRDKRFVTYVLTLTGYYMLA 224
Cdd:cd17503  135 IGPTLGGWLTDNLswrwiFYINLPIGILALLLAPLLDL--------------------RLFKDRNFTLGLLLSFLLGLGL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 225 VQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGL---TSNLQQLF 301
Cdd:cd17503  195 FGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLII 274


                 ....*....
gi 695765344 302 TLICIFYIG 310
Cdd:cd17503  275 LPLFIRGLG 283
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 39-337 8.20e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 8.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  39 DQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDP 118
Cdd:cd17319   31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 119 PRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQY-DFRlvcsvgaALFVACAAFNAWYLPAWklstvktpv 197
Cdd:cd17319  111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWR-------WAFIIEGLLGLLLAVLW--------- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 198 reglgrVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG-SPTAVKWMYAIEAAISLTLLYPIARWSEQRFRLEHR 276
Cdd:cd17319  175 ------WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARR 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695765344 277 L--MAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARGSYMGF 337
Cdd:cd17319  249 LviIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 48-251 1.21e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 53.40  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  48 VGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKL 127
Cdd:cd17475   33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRW 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 128 VRPHQRGRFFSILMMQDSAGAVIGALLGSWL-LQYDFRLVCSVGAALFVACA-AFNAWYL--PAWKLST-VKTPVREGLG 202
Cdd:cd17475  113 FPPRERGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAvLFWLFYRepPAASAATeSASTLLRSLK 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695765344 203 RVLRDKRFvtYVLTLTGYYMLAVQVMLM--LPIMVNDIAG-SPTAVKWMYAI 251
Cdd:cd17475  193 EVLRNRDV--WLIAIAGALLVAPQFALLtfLLLFLHDHLGlSVVAAGALLAV 242
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 28-217 1.82e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 52.56  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  28 VVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFggavADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCI 107
Cdd:cd17478   17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYL----ADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 108 LSGLGGTLFDPPrAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLV-CSVGAALFVACAAFNAWYLP 186
Cdd:cd17478   93 LAGIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGlLILLIIPGLAVALLLLRLRP 171

                        170       180       190
                 ....*....|....*....|....*....|.
gi 695765344 187 AWKLSTVKTPVREGLGRVLRDKRFVTYVLTL 217
Cdd:cd17478  172 LKKPEAKKAAAKSSARSTLKGVWRALLLLLI 202
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 19-180 1.92e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 52.62  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  19 NMLVVLGFFVVFPLISirfVDQMGWAALMVGIALGLrqlvqQGLGIFGGAV-----ADRFGAKPMIVTGMLMRAGGFAAM 93
Cdd:cd06173  220 FALLGGALTVLLPLLA---KEVLGGGAAGYGLLLAA-----FGVGALLGALllgrlSKRRRRGRLLLIGALLLGLALLVL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  94 AVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAA 172
Cdd:cd06173  292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGA 371


                 ....*...
gi 695765344 173 LFVACAAF 180
Cdd:cd06173  372 LLLLAALL 379
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-189 1.94e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.56  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  19 NMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGA--KPMIVTGMLMRAGGFAAMAVA 96
Cdd:COG2271  189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALL 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  97 HEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFV 175
Cdd:COG2271  269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDaTGYQAAFLLLAALAL 348

                        170
                 ....*....|....
gi 695765344 176 ACAAFNAWYLPAWK 189
Cdd:COG2271  349 LAALLALLLLRETR 362
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-180 4.63e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 4.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  13 YFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAA 92
Cdd:cd17473  200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  93 MAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYD------FRLV 166
Cdd:cd17473  280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgglsgaFLIL 359

                        170
                 ....*....|....
gi 695765344 167 CSVGAALFVACAAF 180
Cdd:cd17473  360 GVLALVLAIVLLLL 373
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 13-180 4.83e-07

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 51.45  E-value: 4.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  13 YFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGI---ALGLRQLVQQGLGIfgGAVADRFGAKPMIVTGMLMRAGG 89
Cdd:cd17331  210 AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYlmsYAGVLGMVVQGLLV--GPLTKRFGERSLLKLSVALLAIG 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  90 FAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCS 168
Cdd:cd17331  288 YLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQaYGFPSFGL 367

                        170
                 ....*....|..
gi 695765344 169 VGAALFVACAAF 180
Cdd:cd17331  368 LGAAINGLLTVY 379
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 15-314 7.54e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 50.63  E-value: 7.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  15 LLVDNMLVVLGFFVVFPLISIRFvDQMGWAALMVGIALGLrqlvqQGLGI-----FGGAVADRFGAKPMIVTGMLMRAGG 89
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASA-----YYLGIllgspLVPRLIRRVGHIRAFAAGAAITAVS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  90 FAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSV 169
Cdd:cd17477   75 VLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 170 GAALFVACAAFnawyLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMlPIMVNDIAGSPTAVKWMY 249
Cdd:cd17477  155 AVLLLLALVPL----LLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLL-PLYGLRLGLSVAQAALLL 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695765344 250 AIEAAISLTLLYPIARWSEQRFRLehRLMAGL-LVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVA 314
Cdd:cd17477  230 AAFVLGGLLLQWPLGWLADRFDRR--RVLLGCaLLGALAALLLPLVPGLPLALLVLLFLWGGAAGP 293
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 20-180 1.43e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:cd17324  208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 100 WVLWLSCILSGLGGTLFDPPRAALVVKLVrPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACAA 179
Cdd:cd17324  288 LLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366


                 .
gi 695765344 180 F 180
Cdd:cd17324  367 L 367
MFS_1 pfam07690
Major Facilitator Superfamily;
12-152 1.77e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   12 KYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRA---G 88
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIlaaL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695765344   89 GFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGA 152
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-186 1.79e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  14 FLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAM 93
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  94 AVA--HEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQ-------RGRFFSILMMQDSAGAVIGALLGSWLLQY--- 161
Cdd:COG2211  312 FFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALfgy 391

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 695765344 162 ------------DFRLVCSVGAALFVACAAFNAWYLP 186
Cdd:COG2211  392 vagaaqspsaltGIRLLFFLLPAVLLLLAALLLLFYP 428
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-158 2.31e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.09  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  19 NMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHE 98
Cdd:cd17321  177 AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGA 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695765344  99 P---WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIG-ALLGSWL 158
Cdd:cd17321  257 DssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvALLGALL 320
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 20-180 5.48e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.96  E-value: 5.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIrfvDQMGWAALMVGIAL---GLRQLVQQGLgiFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVA 96
Cdd:cd17330  187 ALAFAGLESVFSLFLK---DRFGFSPSQIGLLLalvGIAGILAQLL--LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  97 HEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVA 176
Cdd:cd17330  262 SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLL 341


                 ....
gi 695765344 177 CAAF 180
Cdd:cd17330  342 IALF 345
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 40-180 1.00e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.19  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  40 QMGWA--ALMVGIALGlrqlvqqglGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFD 117
Cdd:cd17365   35 QLGPVgsAALFGMAIG---------ALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAM 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695765344 118 PPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFVACAAF 180
Cdd:cd17365  106 PNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPaFGWRSVFLLGGVPPLILLPL 169
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 15-184 1.18e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.87  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  15 LLVDNMLVVLGFFVVFPLISIRFVDQMGWA---ALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFA 91
Cdd:cd17391  206 LFVTTFIIQLANQSIEPILTLYIRQLMGDAsnlAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYI 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  92 AMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWL-LQYDFRLVCsVG 170
Cdd:cd17391  286 PQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAVF-VV 364

                        170
                 ....*....|....
gi 695765344 171 AALFVACAAFNAWY 184
Cdd:cd17391  365 TALLVLLNAIWSFI 378
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 20-337 1.24e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:cd17473    9 TLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 100 WVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVaCAA 179
Cdd:cd17473   89 YALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALP-VLI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 180 FNAWYLP--AWKLSTVKTPVREGLGRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISL 257
Cdd:cd17473  168 LVLLFLPepARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGA 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 258 --TLLYPIARwseQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETLGASLADARARGSYM 335
Cdd:cd17473  248 igALLFGRLK---RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAM 324


                 ..
gi 695765344 336 GF 337
Cdd:cd17473  325 GI 326
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 12-176 1.86e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 46.68  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  12 KYFLLVdNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFA 91
Cdd:COG2270  241 LRFLLA-YFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCL 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  92 AMAVAHEPWVLWlscILSGLGGTLFDPPRAA---LVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQY--DFRLV 166
Cdd:COG2270  320 AAYFLTTALAFW---ILGLLIGLVMGGIQALsrsLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLtgSQRLG 396

                        170
                 ....*....|
gi 695765344 167 CSVGAALFVA 176
Cdd:COG2270  397 ILSLIVFFVI 406
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 63-186 1.89e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.58  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344   63 GIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMM 142
Cdd:TIGR00895  69 ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 695765344  143 QDSAGAVIGALLGSWLL-QYDFRLVCSVGAALFVACAAFNAWYLP 186
Cdd:TIGR00895 149 GYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
20-173 1.90e-05

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 46.73  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLvqqgLGIFGGAVADRF-GAKPMIVTGMLMRAGGFAAMAVAHE 98
Cdd:COG3104   33 MRAILVLYLTASLADGGLGLSEADAAAIYGAYTALVYL----TPLLGGWLADRLlGQRRAILLGGILMALGHFLLALPGG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  99 PWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGR--FFSILMMQDSAGAVIGALLGSWLLQ-YDFR---LVCSVGAA 172
Cdd:COG3104  109 VTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRdaGFTIFYMGINIGAFLAPLLCGYLGEkYGWHygfGAAAIGML 188


                 .
gi 695765344 173 L 173
Cdd:COG3104  189 I 189
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 20-173 2.07e-05

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 46.41  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQmgwAALMVGIALGLrqlvQQGLGIFGGAVADRF-GAKPMIVTGMLMRAGGFAAMAVA-H 97
Cdd:cd17346   21 MRAILILYLTAQLGDGFSEAD---AASIYGAYTAL----VYLTPIIGGWLADKVlGARRTVFIGGILMALGYLLLALSpF 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  98 EPWVLWLSCILSGLGGTLFDPPRAALVVKLVRP--HQRGRFFSILMMQDSAGAVIGALLGSWL-LQYDFR---LVCSVGA 171
Cdd:cd17346   94 SVSMLYLGLALIIVGNGLFKPNISSLVGKLYDEndPRRDSGFSIFYMGINLGAFLAPLLCGTLgDNYGYHygfGLAAVGM 173


                 ..
gi 695765344 172 AL 173
Cdd:cd17346  174 LL 175
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 24-194 2.11e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.07  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  24 LGFFVVFPLISIRfVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLW 103
Cdd:cd17390   10 FGVSMILPLLSTH-IRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 104 LSCILSGL-GGTLfdPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYD--FRLVCSVGAALFVACAAF 180
Cdd:cd17390   89 LSRIPLGIfKHTQ--SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLCSAIFILNAGL 166

                        170
                 ....*....|....*.
gi 695765344 181 nAWYLPA--WKLSTVK 194
Cdd:cd17390  167 -VWFLLSklWDLLLVR 181
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 14-182 3.98e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 45.32  E-value: 3.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  14 FLLVDNMLVVLGFFVVFPLIS---IRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGF 90
Cdd:cd17388    3 FILVTVLLDAMGIGLIMPVLPtllREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  91 AAMAVAHEPWVLWLSCILSGLGGTLFdPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFRlvcsvg 170
Cdd:cd17388   83 LLMAFAPTLWWLYLGRIIAGITGATG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPR------ 155

                        170
                 ....*....|..
gi 695765344 171 aALFVACAAFNA 182
Cdd:cd17388  156 -APFLVAAGLNG 166
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 19-156 5.96e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.87  E-value: 5.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  19 NMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHE 98
Cdd:cd17503  187 SFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTP 266

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695765344  99 PWVLW---LSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSIL-MMQDSAGAVIGALLGS 156
Cdd:cd17503  267 DTSLWliiLPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTALLAT 328
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 24-297 1.03e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 44.11  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  24 LGFFVVFPLISIRFvDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIV--TGMLMRAGGFAAMAVAHEPWV 101
Cdd:cd17335   11 AALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLllSLLAAVLFFLSLFFVAQIFWL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 102 LWLSCIL----SGLGGTLFDppraALVVKLVRphQRGRFFSILMMQDSAGAVIGALLGSWLLQYDFR----LVCSVGAAL 173
Cdd:cd17335   90 LLLLVILgaffSAPVVPLVD----SITLQYLG--EERERYGKQRLWGSIGFGIAALLVGILIDRSSTyknyTIAFYVFAV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 174 FVACAAFNAWYLPAWKLSTVKTPVREGLGRVLRDKRFVTYVLT--LTGYYMLAVQVMLMlpIMVNDIAGSPTAVKWMYAI 251
Cdd:cd17335  164 LMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVafLMGFGHGLIYSFLF--WHLQDLGGSKTLIGLLWTV 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 695765344 252 eAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNL 297
Cdd:cd17335  242 -GVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENP 286
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 38-183 1.61e-04

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 43.64  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  38 VDQMGWAALMVGIALGLRQLVQQgLGIFGGAVADRFGAK-----PMIVTGMLMRAGGFAAMAVA------HEPWVLWLSC 106
Cdd:cd06176   28 IVELGLPATLVGLLIALHYLVAP-LRVWIGHRSDTHPLRgyrrtPYIWLGMLLLALGLALAPFAalllagAAFWLGLALA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 107 ILS----GLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQ--YDFRL--VCSVGAALFVACA 178
Cdd:cd06176  107 VLAfllyGIGVGAAGTAFLALLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGRLLDpySPERLiqVFQIVALVALLLA 186


                 ....*
gi 695765344 179 AFNAW 183
Cdd:cd06176  187 LLALW 191
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 58-307 2.71e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.54  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  58 VQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLS-CILSGLGGTLFDPPRAALVVKLVRpHQRGRF 136
Cdd:cd17352   50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGGLGLGLIYSPAIVIVGQYFE-KKRGLA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 137 FSILMMQDSAGAVIGALLGSWLLQ-YDFRLVCSVGAALFVACAAFNAwylpawklstvktpvregLGRVLRDKRFVTYVL 215
Cdd:cd17352  129 TGIAVAGSGVGTFVFPPLLRYLLDnYGWRGALLILGGLCLNLCVCGL------------------LLRLLKDPTFVLLAL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 216 TLTGYYMLAVQVMLMLPIMVNDIAGSPTAVKWMYAIEAAISLT---LLYPIARWseQRFRLEHRLMAGLLVMTIAMLPIG 292
Cdd:cd17352  191 GVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVgriLLGLLADK--PRIGRLYLYIFTLLILGLSLLAFP 268

                        250
                 ....*....|....*
gi 695765344 293 LTSNLQQLFTLICIF 307
Cdd:cd17352  269 LATTYVGLIVFSVLF 283
PRK12382 PRK12382
putative transporter; Provisional
 24-180 2.92e-04

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 42.74  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  24 LGFFVVFPLISIRFVDqMGWAalMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLW 103
Cdd:PRK12382 230 VGFAVIGTFVSLYFAS-KGWA--MAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVAL 306

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695765344 104 LSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSIL-MMQDSAGAVIGALLGSWLLQYDFRLVCSVGAALfVACAAF 180
Cdd:PRK12382 307 AGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYaAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAIS-AVLGII 383
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 28-161 3.32e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 42.54  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  28 VVFPLISIRFVDQMGWAALMVGIALG-------LRQlvqqglgIFGGAVADRFGAKPMIVTGMLM--RAGGFAAMAVAHE 98
Cdd:cd17380   16 VNMPIAIVPMAKEFGWSKTDQGLVLSsffwgyaLTQ-------VLGGYLADRFGGKKVLLLAVALwsLATLLTPLLAYSS 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695765344  99 PWVLWLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLLQY 161
Cdd:cd17380   89 LPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEY 151
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 20-112 3.67e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.21  E-value: 3.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  20 MLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEP 99
Cdd:cd17353   12 MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL 91

                         90
                 ....*....|....
gi 695765344 100 WVLWLSC-ILSGLG 112
Cdd:cd17353   92 PLLFLGYgVLGGIG 105
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 13-309 5.52e-04

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 41.63  E-value: 5.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  13 YFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAALMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAA 92
Cdd:cd17314    5 LYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  93 MAVAHEPWVLWLSC-ILSGLGGTLFDPPrAALVVKLVRPHQRGRFFSILmmqdSAGAVIGALLGSWLLQYDFRLVCSVGA 171
Cdd:cd17314   85 LSYVFNSFPLSYACfVFIGAGTGILYGS-AVLVTTQYFPDTKGLALGLP----TTGYSLGLVLGSPLLRILWVFYGLALV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 172 ALFVACAAFNAWYLPAwkLSTVKTPVRE------------GLGRVLRDKRF----VTYVLTLTGYYMLavqVMLMLPIMV 235
Cdd:cd17314  160 YTILGILAAIVLSVVS--LLGFKEPPDNqarlhvqkkktqTMGEIFRDKVFwilfIAIFLVLIGGFLF---IANMASLVR 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695765344 236 NDIAGSPTAVKWMYAIeAAISLTLLYPIARWSEQRFRLEHRLMA---GLLVMTIAMLPIGLTSNLQQLFTLICIFYI 309
Cdd:cd17314  235 SLQLDAPSFVTKLMSI-YGLFNAFGRLLWGIVADFFGGRLSTLSillTILGLGLCAFLFLLKMTPVGLVLTGSLLGF 310
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 26-180 6.93e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.49  E-value: 6.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  26 FFVVFPLISIRFV---DQMGWAALMVGIALGLRQLVQqglgifgGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVL 102
Cdd:cd17312   22 FSVAKPPIVEEIGlskDDLGIIGSAFLIAYAVGKFIS-------GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFF 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695765344 103 WLSCILSGLGGTLFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALL-GSWLLQYDFRLVCSVGAALFVACAAF 180
Cdd:cd17312   95 AVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILaASLASYYGWRAAFLVPGIVGLVVAII 173
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
26-321 2.15e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 39.90  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  26 FFVVFPLISIrFVDQMGWAA-----LMVGIALGLRQLVQQGLGIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPW 100
Cdd:PRK09874  30 FSLVMPFLPL-YVEQLGVTGhsalnMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIW 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 101 -VLWLSCILSGLGGtlFDPPRAALVVKLVRPHQRGRFFSILMMQDSAGAVIGALLGSWLL-QYDFRLVCSVGAALFVACA 178
Cdd:PRK09874 109 qFLILRALLGLLGG--FVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAdSYGLRPVFFITASVLFLCF 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344 179 AFNAW-----YLPAWKLSTVKtpVREGLGRvLRDKRFVTYVLTLTGYYMLAV-QVMLMLPIMVNDIAGSPTAVKW---MY 249
Cdd:PRK09874 187 LVTLFcirenFQPVSKKEMLH--MREVVTS-LKNPKLVLSLFVTTLIIQVATgSIAPILTLYVRELAGNVSNIAFisgMI 263

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695765344 250 AIEAAISLTLLYPIARWSEQRFRLEHRLMAGLLVMTIAMLPIGLTSNLQQLFTLICIFYIGSIVAEPARETL 321
Cdd:PRK09874 264 ASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTL 335
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 63-158 2.85e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  63 GIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGL--GGTLfdPPRAALVVKLVRPHQRGRFFSIL 140
Cdd:cd17316   53 ALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgiGGEY--PGASTYVAEFAPSKRRGFALGLL 130

                         90
                 ....*....|....*...
gi 695765344 141 MMQDSAGAVIGALLGSWL 158
Cdd:cd17316  131 QSGWALGALLAALVASLL 148
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 63-189 5.43e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.46  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765344  63 GIFGGAVADRFGAKPMIVTGMLMRAGGFAAMAVAHEPWVLWLSCILSGLGGTLFDPPRAALVVKLVrPHQRGRFFSILMM 142
Cdd:cd17333   48 SLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHG 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695765344 143 QDSAGAVIGALLGSWLLQYDFRLVCSVGAALFVACAAFNAWYLPAWK 189
Cdd:cd17333  127 FFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFP 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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