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Conserved domains on  [gi|695765269|ref|WP_032688303|]
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MULTISPECIES: MFS transporter [Raoultella]

Protein Classification

MFS transporter( domain architecture ID 11457990)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0005886|GO:0016020|GO:0022857|GO:0055085
PubMed:  26098515|9529885|26758938|23403214
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-355 1.21e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.40  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   5 PGRIPAILAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTA 84
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  85 GGLLSFLAvlkGSFLLFCTGCFLVGVYQA-FSQYYRLVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlp 163
Cdd:COG2814   88 GSLLCALA---PSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 164 rFAGVYLVVAALGIMSALNLALFFGRSKKYPSAPDTAAPpvrsptsRELMKRPDYRTAWFHLVVGSLVMLFLMTAAP--L 241
Cdd:COG2814  163 -WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPlyL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 242 SVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMF 321
Cdd:COG2814  235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                        330       340       350
                 ....*....|....*....|....*....|....
gi 695765269 322 VGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIA 355
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-355 1.21e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.40  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   5 PGRIPAILAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTA 84
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  85 GGLLSFLAvlkGSFLLFCTGCFLVGVYQA-FSQYYRLVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlp 163
Cdd:COG2814   88 GSLLCALA---PSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 164 rFAGVYLVVAALGIMSALNLALFFGRSKKYPSAPDTAAPpvrsptsRELMKRPDYRTAWFHLVVGSLVMLFLMTAAP--L 241
Cdd:COG2814  163 -WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPlyL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 242 SVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMF 321
Cdd:COG2814  235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                        330       340       350
                 ....*....|....*....|....*....|....
gi 695765269 322 VGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIA 355
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 121-387 1.88e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.82  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 121 VAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYLVVAALGIMSALnLALFFGRSKKYPSAPDTA 200
Cdd:cd17325  108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG---YRAPFLVCAALALLALV-LALLLLPEPRPPPNKRAV 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 201 APPVRSPTSRELMKRPDYRTAWFHLVVGSLVMLFLMTAAPLSVTHHHSMNDG--ALVIQLHLLGMYVPSLFTGLLIRKVG 278
Cdd:cd17325  184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqiGLLFGAQGLASALSQPPAGKLSDRIG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 279 ITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSG 358
Cdd:cd17325  264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                        250       260
                 ....*....|....*....|....*....
gi 695765269 359 AGVMLALLGWKLLGLMMLPVLLICLVSTW 387
Cdd:cd17325  344 GGFLYDAFGFATPFLAAAALLLLAAVLFL 372
MFS_1 pfam07690
Major Facilitator Superfamily;
11-356 7.56e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   11 ILAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVcgtAGGLLSF 90
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---LFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   91 LAVLKGSFLLFCTGCFLVGVYQA-FSQYYRLVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVY 169
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---WRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  170 LVVAALGIMSALNLALFFGRSKKYPSAPDTAAPPVRSPTSRELMKRPDYRTAWFHLVVGSLVMLFLMTAAPLSVTHHHSM 249
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  250 NDGALVIQLHLLGMYVPSLFTGLLIRKVG---ITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGST 326
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGrrrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314

                         330       340       350
                  ....*....|....*....|....*....|
gi 695765269  327 LLSLSYRDHERKKAQGLAETSRFIFSAIAT 356
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-355 1.21e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.40  E-value: 1.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   5 PGRIPAILAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTA 84
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  85 GGLLSFLAvlkGSFLLFCTGCFLVGVYQA-FSQYYRLVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlp 163
Cdd:COG2814   88 GSLLCALA---PSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 164 rFAGVYLVVAALGIMSALNLALFFGRSKKYPSAPDTAAPpvrsptsRELMKRPDYRTAWFHLVVGSLVMLFLMTAAP--L 241
Cdd:COG2814  163 -WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPlyL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 242 SVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMF 321
Cdd:COG2814  235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                        330       340       350
                 ....*....|....*....|....*....|....
gi 695765269 322 VGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIA 355
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 121-387 1.88e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.82  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 121 VAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYLVVAALGIMSALnLALFFGRSKKYPSAPDTA 200
Cdd:cd17325  108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG---YRAPFLVCAALALLALV-LALLLLPEPRPPPNKRAV 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 201 APPVRSPTSRELMKRPDYRTAWFHLVVGSLVMLFLMTAAPLSVTHHHSMNDG--ALVIQLHLLGMYVPSLFTGLLIRKVG 278
Cdd:cd17325  184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqiGLLFGAQGLASALSQPPAGKLSDRIG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 279 ITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSG 358
Cdd:cd17325  264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                        250       260
                 ....*....|....*....|....*....
gi 695765269 359 AGVMLALLGWKLLGLMMLPVLLICLVSTW 387
Cdd:cd17325  344 GGFLYDAFGFATPFLAAAALLLLAAVLFL 372
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 12-387 5.89e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 60.30  E-value: 5.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  12 LAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFL 91
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  92 AvlkGSFLLFCTGCFLVGV-YQAFSQYYRLVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYL 170
Cdd:cd17489   81 A---TSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG---FAVLFI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 171 VVAalgIMSALNLALFFGRSKKYPSAPDTAAPPVRSPTSRelmkrpDYRTAWFH---LVVGSLVMLFLMTAAPLSVTHHH 247
Cdd:cd17489  155 VAA---VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRL------VEKKVLPPaliLFLASIAYGAISTFLPLYAAERG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 248 sMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTL 327
Cdd:cd17489  226 -ISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 328 LSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVMLALLGWKLLGLMMLPVLLICLVSTW 387
Cdd:cd17489  305 AVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
MFS_1 pfam07690
Major Facilitator Superfamily;
11-356 7.56e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.12  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   11 ILAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVcgtAGGLLSF 90
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---LFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269   91 LAVLKGSFLLFCTGCFLVGVYQA-FSQYYRLVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVY 169
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---WRAAF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  170 LVVAALGIMSALNLALFFGRSKKYPSAPDTAAPPVRSPTSRELMKRPDYRTAWFHLVVGSLVMLFLMTAAPLSVTHHHSM 249
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  250 NDGALVIQLHLLGMYVPSLFTGLLIRKVG---ITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGST 326
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGrrrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314

                         330       340       350
                  ....*....|....*....|....*....|
gi 695765269  327 LLSLSYRDHERKKAQGLAETSRFIFSAIAT 356
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-387 3.59e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.74  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  12 LAVSNLFFTCAVSVDLTIATLVGYQLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFL 91
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  92 AVlkgSFLLFCTGCFLVGVYQAFSQYYRL-VAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGLPRFAGVYL 170
Cdd:cd06174   81 AP---SFWLLLLGRFLLGLGSGLIDPAVLaLIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 171 VVAALGIMSALNLALFFGRSKKYPSAPDTAAPPVRSPTSRELMKRPDYRT-AWFHLVVGSLVMLFLMTAAPLSVTHHHSM 249
Cdd:cd06174  158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLlLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 250 NDGALVIQL--HLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTL 327
Cdd:cd06174  238 VAVAGLLLSlfGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695765269 328 LSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVMLAL-LGWKLLGLMMLPVLLICLVSTW 387
Cdd:cd06174  318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 52-387 1.83e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 52.55  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  52 TVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFLAVlkgSFLLFCTGCFLVGVYQA-FSQYYRLVAADHSPPEV 130
Cdd:cd17324   44 ALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP---SFALLLLARALAGLAHGgFWAIAAAYAADLVPPEK 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 131 KGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYLVVAALGIMSALNLALFFGRSkkyPSAPDTAAPPVRSPtsR 210
Cdd:cd17324  121 RGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG---WRAAFLAIAVLALLAALLLWRLLPSL---PPKKPGSLGLLSSL--L 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 211 ELMKRPDYRTAWFH--LVVGSLVMLFLMTAAPLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIA 288
Cdd:cd17324  193 LLLRNPRLRLAYLItfLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 289 LNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHeRKKAQGLAETSRFIFSAIATSGAGVMLALLGW 368
Cdd:cd17324  273 LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGW 351

                        330
                 ....*....|....*....
gi 695765269 369 KLLGLMMLPVLLICLVSTW 387
Cdd:cd17324  352 AGVGWVGAALLLLALLLAL 370
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
42-400 2.67e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.08  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  42 ELATVPFALiTVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFLAvlkGSFLLFCTGCFLVGVYQAFSQYYRLV 121
Cdd:COG0738   44 QAGLLLFAF-FLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA---PSYPLLLLALFLLGLGLGLLDVAANP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 122 AADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGLPRFAGVYLVVAALGIMsalnLALFFGRSKKYPSAPDTAA 201
Cdd:COG0738  120 YVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLL----LALLFLRSKLPEIEEEEEE 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 202 PPVRSPTSRELMKRPDYRTAWFHLV--VGSLVMLFLMTAAPLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGI 279
Cdd:COG0738  196 AAGSAASLKSLLKNPRLLLGGLAIFlyVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 280 TVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFvggSTLLSLSYRDHERKKAQGLAetsrfIFSAIATSGA 359
Cdd:COG0738  276 VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF---PTIFSLALDGLGKRTAAAVS-----AVLIMGIVGG 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 695765269 360 GVMLALLGW--KLLGLMM-LPVLLICLVSTWQYGHAVRKERATA 400
Cdd:COG0738  348 AIGPPLIGFlaDAFGLRAaFLVPLVCYLLILLLALALKRKRRKK 391
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
11-399 7.01e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.95  E-value: 7.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  11 ILAVSNLFFTCAVSVDLTIATLVGY---QLAPSDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGL 87
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPlaeEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  88 LSFLAVlkgSFLLFCTGCFLVGVYQA--FSQYYRLVAAdHSPPEVKGQSISLVMIGGVVAAILGPLLtiiardVPGLPRF 165
Cdd:COG2223   86 LLALAV---SYWLLLLLGLLLGIGGGgsFAVGIALVSK-WFPPDRRGLALGLAAGGGNLGAAVAAFL------APLLIAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 166 AGVYLVVAALGIMSALnLALFFGRSKKYPSAPDTAAPPVRSPTSRELMKRPD-YRTAWFHLVVGSLVMLFLMTAAPLSVT 244
Cdd:COG2223  156 FGWRNAFLILGILLLV-VAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRfWLLSLLYFGTFGSFIGFSSWLPPYLVD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 245 HHH-SMNDGALVIQLHLLGMYVPSLFTGLLIRKVG-ITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFV 322
Cdd:COG2223  235 QFGlSAATAGLLAALFALLGALGRPLGGWLSDRIGgRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695765269 323 GGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVMLALLG-WKLLGLMMLPVLLICLVSTWQYGHAVRKERAT 399
Cdd:COG2223  315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
40-387 4.77e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.17  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  40 SDELATVPFALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFLAvlkGSFLLFCTGCFLVGVYQAFSQYYR 119
Cdd:COG2807   51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA---PSVALLLAGTALIGAGIAVGNVLL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 120 LVAADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYLVVAALGIMSALNLALFFGRskkypsAPDT 199
Cdd:COG2807  128 PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG---WRGALAVWALLALLALLLWLPLLRR------RPAA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 200 AAPPVRSPTSRELMKRPDYRTAWFHLVVGSLVMLFLMT-AAPLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVG 278
Cdd:COG2807  199 AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAwLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 279 ITVLLYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRD-HERKKAQGLAETSRFIFSAIATS 357
Cdd:COG2807  279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPL 358

                        330       340       350
                 ....*....|....*....|....*....|.
gi 695765269 358 GAGVMLALLG-WKLLGLMMLPVLLICLVSTW 387
Cdd:COG2807  359 LVGALHDATGsWTAALLLLAALAVLMLVAGL 389
MFS_1 pfam07690
Major Facilitator Superfamily;
225-405 2.26e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  225 LVVGSLVMLFLMTAAPLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETML 304
Cdd:pfam07690   7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  305 AYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVMLALLGWKLLGLMMLPVLLICLV 384
Cdd:pfam07690  87 LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV 166

                         170       180
                  ....*....|....*....|.
gi 695765269  385 STWQYGHAVRKERATASRSAE 405
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEAR 187
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
44-192 2.51e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  44 ATVPFALITVAGAFSSLFAAGMIGR-GNEKLAFMLGSVCGTAGGLLSFLAVLKGSFLLFCTGCFLVGVYQAFSQYYrLVA 122
Cdd:COG2271  218 AGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW-ALA 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 123 ADHSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYLVVAALGIMSALNLALFFGRSKK 192
Cdd:COG2271  297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG---YQAAFLLLAALALLAALLALLLLRETRK 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
224-404 2.86e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 224 HLVVGSLVMLFLMTAAPLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGETM 303
Cdd:COG2814   19 AFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 304 LAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVMLALLGWKLLGLMMLPVLLICL 383
Cdd:COG2814   99 WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLAL 178

                        170       180
                 ....*....|....*....|.
gi 695765269 384 VSTWQYGHAVRKERATASRSA 404
Cdd:COG2814  179 LLLLRLLPESRPAARARLRGS 199
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 261-364 3.64e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.10  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 261 LGMYVPSLFTGLLIRKVGITVLLYAGIALNM-SAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKK 339
Cdd:cd17504  228 LVMLIAGPLAGRLIARVGPRRVLLIGLVISAvGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGI 307

                         90       100
                 ....*....|....*....|....*
gi 695765269 340 AQGLAETSRFIFSAIATSGAGVMLA 364
Cdd:cd17504  308 ATGMNTVLRTIGSAIGPAIAGAILT 332
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
223-387 4.14e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 223 FHLVVGSLVMLFLMTAAPLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVGITVLLYAGIALNMSAIMVNLTGET 302
Cdd:COG2271   18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 303 MLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVMLALLGWK-LLGLMMLPVLLI 381
Cdd:COG2271   98 FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRaAFLILGLPGLLL 177


                 ....*.
gi 695765269 382 CLVSTW 387
Cdd:COG2271  178 ALLRFW 183
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
48-395 5.54e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 38.70  E-value: 5.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  48 FALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFLAvlkGSFLLFCTGCFLVGVYQA--FSQYYRLVAaDH 125
Cdd:COG2271   51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA---TSFWQLLLLRFLLGLGEAgfFPAALKLIA-EW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 126 SPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGLPrfaGVYLVVAALGI-MSALNLALFFGrskkypsapdtaappv 204
Cdd:COG2271  127 FPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR---AAFLILGLPGLlLALLRFWLLAL---------------- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 205 rsptsrelmkrpdyrtAWFHLVVGSLVMLFLMTAApLSVTHHHSMNDGALVIQLHLLGMYVPSLFTGLLIRKVG--ITVL 282
Cdd:COG2271  188 ----------------AYFLVYFALYGFLTWLPTY-LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLV 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 283 LYAGIALNMSAIMVNLTGETMLAYGLSLLLVGVGWNFMFVGGSTLLSLSYRDHERKKAQGLAETSRFIFSAIATSGAGVM 362
Cdd:COG2271  251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330

                        330       340       350
                 ....*....|....*....|....*....|...
gi 695765269 363 LALLGWKLLGLMMLPVLLICLVSTWQYGHAVRK 395
Cdd:COG2271  331 LDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 48-213 7.51e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 38.30  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269  48 FALITVAGAFSSLFAAGMIGRGNEKLAFMLGSVCGTAGGLLSFlAVLKGSFLLFCTGCFLVGV-YQAFSQYYRLV--AAD 124
Cdd:cd17471   38 MTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF-AFLRNYWVLLLVGVVLLSLgAAAFPQLFALAreYAD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695765269 125 HSPPEVKGQSISLVMIGGVVAAILGPLLTIIARDVPGlprFAGVYLVVAALGIMSALNLALFFGRSKKYPSAPDTAAPPV 204
Cdd:cd17471  117 RSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG---FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLV 193


                 ....*....
gi 695765269 205 RSPTSRELM 213
Cdd:cd17471  194 KAPVNRRLL 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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