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Conserved domains on  [gi|695764507|ref|WP_032687546|]
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MULTISPECIES: anti-virulence regulator CigR family protein [Raoultella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 8-170 6.34e-74

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


:

Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 218.17  E-value: 6.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764507   8 KTALAAVISLVVVAAPVYANPGNGNGGGHGNGGsnhgnsgnhgnsadhsNKGQGNGKSGEDHGNRKNYGKPDHVDSDISF 87
Cdd:NF040487   1 LAALAAVLSLALGSAPALADPGNGKGNGNGNGG----------------HGNHGNKGNGGNGGKKKNGGDPDLVGPSISY 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764507  88 SRARSLAVNYGLVGYKALPPGIAKNLVRGKPLPPGIAKKTLPASMINDLPYYPGYEWRAVGDDLVLVALSTAIVTSIING 167
Cdd:NF040487  65 GRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVALATGIVYEVLNG 144


                 ...
gi 695764507 168 VFD 170
Cdd:NF040487 145 VFD 147
 
Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 8-170 6.34e-74

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 218.17  E-value: 6.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764507   8 KTALAAVISLVVVAAPVYANPGNGNGGGHGNGGsnhgnsgnhgnsadhsNKGQGNGKSGEDHGNRKNYGKPDHVDSDISF 87
Cdd:NF040487   1 LAALAAVLSLALGSAPALADPGNGKGNGNGNGG----------------HGNHGNKGNGGNGGKKKNGGDPDLVGPSISY 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764507  88 SRARSLAVNYGLVGYKALPPGIAKNLVRGKPLPPGIAKKTLPASMINDLPYYPGYEWRAVGDDLVLVALSTAIVTSIING 167
Cdd:NF040487  65 GRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVALATGIVYEVLNG 144


                 ...
gi 695764507 168 VFD 170
Cdd:NF040487 145 VFD 147
RcnB COG5455
Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];
101-167 1.65e-03

Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];


Pssm-ID: 444206 [Multi-domain]  Cd Length: 121  Bit Score: 36.62  E-value: 1.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764507 101 GYKALPPGIAKNLVRGKPLPPGIAKKTLpasMIND-----LPYYP-GYEWRAVGDDLVLVALSTAIVTSIING 167
Cdd:COG5455   51 HRGAGPGEDYKRWRRGDRLPPEYRGRRY---VVNDwrrygLPAPPrGYHWVRVGGDYVLVAIATGIIVSIVLG 120
 
Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 8-170 6.34e-74

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 218.17  E-value: 6.34e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764507   8 KTALAAVISLVVVAAPVYANPGNGNGGGHGNGGsnhgnsgnhgnsadhsNKGQGNGKSGEDHGNRKNYGKPDHVDSDISF 87
Cdd:NF040487   1 LAALAAVLSLALGSAPALADPGNGKGNGNGNGG----------------HGNHGNKGNGGNGGKKKNGGDPDLVGPSISY 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764507  88 SRARSLAVNYGLVGYKALPPGIAKNLVRGKPLPPGIAKKTLPASMINDLPYYPGYEWRAVGDDLVLVALSTAIVTSIING 167
Cdd:NF040487  65 GRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVALATGIVYEVLNG 144


                 ...
gi 695764507 168 VFD 170
Cdd:NF040487 145 VFD 147
RcnB COG5455
Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];
101-167 1.65e-03

Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];


Pssm-ID: 444206 [Multi-domain]  Cd Length: 121  Bit Score: 36.62  E-value: 1.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764507 101 GYKALPPGIAKNLVRGKPLPPGIAKKTLpasMIND-----LPYYP-GYEWRAVGDDLVLVALSTAIVTSIING 167
Cdd:COG5455   51 HRGAGPGEDYKRWRRGDRLPPEYRGRRY---VVNDwrrygLPAPPrGYHWVRVGGDYVLVAIATGIIVSIVLG 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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