|
Name |
Accession |
Description |
Interval |
E-value |
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
3-298 |
1.28e-180 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 499.68 E-value: 1.28e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 3 QRIAMAPQGPEFSRFVMGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVS 82
Cdd:COG4989 2 KRIKLGASGLSVSRIVLGCMRLGEWDLSPAEAAALIEAALELGITTFDHADIYGGYTCEALFGEALKLSPSLREKIELQT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 83 KCGIATKA-RAENTIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFT 161
Cdd:COG4989 82 KCGIRLPSeARDNRVKHYDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHFGVSNFT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 162 PAQFTLLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGGRLFN--DESFQPLRDELAQVAKELNA 239
Cdd:COG4989 162 PSQFELLQSALDQPLVTNQIELSLLHTDAFDDGTLDYCQLNGITPMAWSPLAGGRLFGgfDEQFPRLRAALDELAEKYGV 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 695764355 240 eSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKAALGYDVP 298
Cdd:COG4989 242 -SPEAIALAWLLRHPAGIQPVIGTTNPERIKAAAAALDIELTREEWYELYEAARGHEVP 299
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
9-292 |
7.93e-166 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 461.64 E-value: 7.93e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 9 PQGPEFSRFVMGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGIAT 88
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQTKCGIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 89 K-ARAENTIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTL 167
Cdd:cd19092 81 GdDPRPGRIKHYDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 168 LQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGGRLF--NDESFQPLRDELAQVAKELNAeSIEQV 245
Cdd:cd19092 161 LQSYLDQPLVTNQIELSLLHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFggFDERFQRLRAALEELAEEYGV-TIEAI 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 695764355 246 VYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKAA 292
Cdd:cd19092 240 ALAWLLRHPARIQPILGTTNPERIRSAVKALDIELTREEWYEIYEAA 286
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
15-273 |
3.13e-54 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 176.17 E-value: 3.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGYWRLmDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhLRGRMEIVSKCGiatkARAEN 94
Cdd:cd06660 1 SRLGLGTMTF-GGDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRG-NRDDVVIATKGG----HPPGG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 95 TIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPF 174
Cdd:cd06660 75 DPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 175 T----LATNQVEISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGGrlfndesfqplrdelaqvakelnaesIEQVVYAWI 250
Cdd:cd06660 155 HglpgFAAVQPQYSLLDRSPMEEELLDWAEENGLPLLAYSPLARG--------------------------PAQLALAWL 208
|
250 260
....*....|....*....|...
gi 695764355 251 LRLPSQPLPIIGSGKIERVRSAV 273
Cdd:cd06660 209 LSQPFVTVPIVGARSPEQLEENL 231
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
11-298 |
2.23e-52 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 173.83 E-value: 2.23e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRL--MDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphlRGRMEIVskcgIAT 88
Cdd:COG0667 10 GLKVSRLGLGTMTFggPWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKG----RPRDDVV----IAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 89 KARAENTIGHYITD--RDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFT 166
Cdd:COG0667 82 KVGRRMGPGPNGRGlsREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 167 LLQSRLPFT--LATNQVEISPVHQPlLLDGTLDQLQQLRIRPMAWSCLGGGRL-----------------------FNDE 221
Cdd:COG0667 162 RALAIAEGLppIVAVQNEYSLLDRS-AEEELLPAARELGVGVLAYSPLAGGLLtgkyrrgatfpegdraatnfvqgYLTE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695764355 222 SFQPLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKAALGYDVP 298
Cdd:COG0667 241 RNLALVDALRAIAAEHGV-TPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALDAALAAVPAP 316
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
18-292 |
3.92e-46 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 157.09 E-value: 3.92e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 18 VMGYWRL--MDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGIAtkaraent 95
Cdd:pfam00248 2 GLGTWQLggGWGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDG-------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 96 IGHYITD--RDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLP 173
Cdd:pfam00248 74 DGPWPSGgsKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 174 FTLATNQVEISPVhQPLLLDGTLDQLQQLRIRPMAWSCLGGGRL--------------------FNDESFQPLRDELAQV 233
Cdd:pfam00248 154 IPIVAVQVEYNLL-RRRQEEELLEYCKKNGIPLIAYSPLGGGLLtgkytrdpdkgpgerrrllkKGTPLNLEALEALEEI 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 695764355 234 AKELNaESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKAA 292
Cdd:pfam00248 233 AKEHG-VSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
11-289 |
8.28e-43 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 148.44 E-value: 8.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRL--MDW-NMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphLRGRMEIVSKCGIA 87
Cdd:cd19084 1 DLKVSRIGLGTWAIggTWWgEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKG---RRDDVVIATKCGLR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 88 tkaRAENTIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTL 167
Cdd:cd19084 78 ---WDGGKGVTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 168 LQSRLPFtlATNQVEISPVHQ-------PLlldgtldqLQQLRIRPMAWSCLGGGRL---------------------FN 219
Cdd:cd19084 155 ARKYGPI--VSLQPPYSMLEReieeellPY--------CRENGIGVLPYGPLAQGLLtgkykkeptfppddrrsrfpfFR 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764355 220 DESF---QPLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIR 289
Cdd:cd19084 225 GENFeknLEIVDKLKEIAEKYGK-SLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
27-271 |
5.77e-40 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 140.19 E-value: 5.77e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGrmEIVskcgIATKARAENtigHyitDRDHI 106
Cdd:COG0656 13 WQLPGEEAAAAVRTALEAGYRHIDTAAMYGN---EEGVGEAIAASGVPRE--ELF----VTTKVWNDN---H---GYDDT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 VLSAEQSLRNLATDHLDLLLIHRPDPlMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPV 186
Cdd:COG0656 78 LAAFEESLERLGLDYLDLYLIHWPGP-GPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 187 HQPlllDGTLDQLQQLRIRPMAWSCLGGGRLFNDEsfqplrdELAQVAKELNAeSIEQVVYAWILRLPSQPLPiiGSGKI 266
Cdd:COG0656 157 LQQ---RELLAFCREHGIVVEAYSPLGRGKLLDDP-------VLAEIAEKHGK-TPAQVVLRWHLQRGVVVIP--KSVTP 223
|
....*
gi 695764355 267 ERVRS 271
Cdd:COG0656 224 ERIRE 228
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
38-271 |
4.97e-35 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 126.83 E-value: 4.97e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKcgiatkaraentIGHYITDRDHIVLSAEQSLRNL 117
Cdd:cd19071 20 VLAALEAGYRHIDTAAAYGN---EAEVGEAIRESGVPREELFITTK------------LWPTDHGYERVREALEESLKDL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 118 ATDHLDLLLIHRPDPLMDAD------EVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPll 191
Cdd:cd19071 85 GLDYLDLYLIHWPVPGKEGGskearlETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYLQQ-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 192 lDGTLDQLQQLRIRPMAWSCLGGGRLfndesfQPLRDE-LAQVAKELNAeSIEQVVYAWILRLPSQPLPiiGSGKIERVR 270
Cdd:cd19071 163 -KELVEFCKEHGIVVQAYSPLGRGRR------PLLDDPvLKEIAKKYGK-TPAQVLLRWALQRGVVVIP--KSSNPERIK 232
|
.
gi 695764355 271 S 271
Cdd:cd19071 233 E 233
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
13-289 |
4.43e-33 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 122.34 E-value: 4.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 13 EFSRFVMGYWRLMDWNMS-VNERVSFIEQ---HLDLGVTTVDHADIYGDYQCEAAFGEALKQaphlRGRMEIVskcgIAT 88
Cdd:cd19072 3 EVPVLGLGTWGIGGGMSKdYSDDKKAIEAlryAIELGINLIDTAEMYGGGHAEELVGKAIKG----FDREDLF----ITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 89 KARAENtiGHYitdrDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLL 168
Cdd:cd19072 75 KVSPDH--LKY----DDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 169 QSRL-PFTLATNQVEISPVHQPlLLDGTLDQLQQLRIRPMAWSCLGGGRLFNDesfqPLRDELAQVAKELNAeSIEQVVY 247
Cdd:cd19072 149 QSYLkKGPIVANQVEYNLFDRE-EESGLLPYCQKNGIAIIAYSPLEKGKLSNA----KGSPLLDEIAKKYGK-TPAQIAL 222
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 695764355 248 AWILRLPSQpLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIR 289
Cdd:cd19072 223 NWLISKPNV-IAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
15-281 |
4.65e-31 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 117.69 E-value: 4.65e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGYWRLMD--WNMSVNERVSF--IEQHLDLGVTTVDHADIYGDYQCEAAFGEALKqaphlRGRMEIVskcgIATKA 90
Cdd:cd19085 2 SRLGLGCWQFGGgyWWGDQDDEESIatIHAALDAGINFFDTAEAYGDGHSEEVLGKALK-----GRRDDVV----IATKV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 91 RAENTighyitDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQS 170
Cdd:cd19085 73 SPDNL------TPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 171 RLPFTlaTNQVEISpvhqpLL----LDGTLDQLQQLRIRPMAWSCLGGG----------------------RLFNDESFQ 224
Cdd:cd19085 147 AGRID--SNQLPYN-----LLwraiEYEILPFCREHGIGVLAYSPLAQGlltgkfssaedfppgdartrlfRHFEPGAEE 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 225 ---PLRDELAQVAKELNaESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMS 281
Cdd:cd19085 220 etfEALEKLKEIADELG-VTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLELS 278
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
42-276 |
5.53e-31 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 116.55 E-value: 5.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDYQCEAAFGEALKQAPHlrgRMEIVSKCGIAtkaRAENTIGHYITDRDHIVLSAEQSLRNLATDH 121
Cdd:cd19088 34 LELGVNFIDTADSYGPDVNERLIAEALHPYPD---DVVIATKGGLV---RTGPGWWGPDGSPEYLRQAVEASLRRLGLDR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 122 LDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQftLLQSRLPFTLATNQVEISPVHQPllLDGTLDQLQQ 201
Cdd:cd19088 108 IDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQ--IEEARAIVRIVSVQNRYNLANRD--DEGVLDYCEA 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695764355 202 LRIRPMAWSCLGGGRLfndesFQPLRDeLAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAE 276
Cdd:cd19088 184 AGIAFIPWFPLGGGDL-----AQPGGL-LAEVAARLGA-TPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAA 251
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
11-281 |
1.21e-30 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 116.91 E-value: 1.21e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMD-----WNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKqapHLRGRMEIVskcg 85
Cdd:cd19079 9 GLKVSRLCLGCMSFGDpkwrpWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALK---EFAPRDEVV---- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 86 IATKARAE-----NTIGhyiTDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNF 160
Cdd:cd19079 82 IATKVYFPmgdgpNGRG---LSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 161 TPAQFTLLQ--SRL----PFTLATNQV---------EISPVhqpllldgtldqLQQLRIRPMAWSCLGGGRL-------- 217
Cdd:cd19079 159 YAWQFAKALhlAEKngwtKFVSMQNHYnllyreeerEMIPL------------CEEEGIGVIPWSPLARGRLarpwgdtt 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 218 ----------------FNDESFqPLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMS 281
Cdd:cd19079 227 errrsttdtaklkydyFTEADK-EIVDRVEEVAKERGV-SMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLS 304
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
20-270 |
1.25e-30 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 116.94 E-value: 1.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 20 GYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAphlrgRMEIVskcgIATKARAE-----N 94
Cdd:cd19091 27 GGFFGAWGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGR-----RDDVL----IATKVRGRmgegpN 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 95 TIGhyiTDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQS---R 171
Cdd:cd19091 98 DVG---LSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVSNFSAWQIMKALGiseR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 172 LPFT-LATNQVEISPV-----HQ--PLLLDgtldqlQQLRIrpMAWSCLGGGRL-------------------------F 218
Cdd:cd19091 175 RGLArFVALQAYYSLLgrdleHElmPLALD------QGVGL--LVWSPLAGGLLsgkyrrgqpapegsrlrrtgfdfppV 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 695764355 219 NDESFQPLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVR 270
Cdd:cd19091 247 DRERGYDVVDALREIAKETGA-TPAQVALAWLLSRPTVSSVIIGARNEEQLE 297
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
27-252 |
2.11e-30 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 114.66 E-value: 2.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIAtkaraentigHYITDRdhI 106
Cdd:cd19140 16 YPLTGEECTRAVEHALELGYRHIDTAQMYGN---EAQVGEAIAASGVPRDELFLTTKVWPD----------NYSPDD--F 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 VLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPv 186
Cdd:cd19140 81 LASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEYHP- 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695764355 187 hqplLLDGT--LDQLQQLRIRPMAWSCLGGGRLFNDESFQplrdELAqvakELNAESIEQVVYAWILR 252
Cdd:cd19140 160 ----YLDQRklLDAAREHGIALTAYSPLARGEVLKDPVLQ----EIG----RKHGKTPAQVALRWLLQ 215
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
30-288 |
2.36e-30 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 116.16 E-value: 2.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 30 SVNERVSF--IEQHLDLGVTTVDHADIYGDYQC-------EAAFGEALKQaphLRGRMEIVskcgIATKARAENTIGHYI 100
Cdd:cd19081 22 TADEETSFalLDAFVDAGGNFIDTADVYSAWVPgnaggesETIIGRWLKS---RGKRDRVV----IATKVGFPMGPNGPG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 101 TDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQ---------------F 165
Cdd:cd19081 95 LSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSAWRlqealelsrqhglprY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 166 TLLQSRLpftlatNQVEISPVHQPLlldgtLDQLQQLRIRPMAWSCLGGG-----------------------RLFNDES 222
Cdd:cd19081 175 VSLQPEY------NLVDRESFEGEL-----LPLCREEGIGVIPYSPLAGGfltgkyrseadlpgstrrgeaakRYLNERG 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695764355 223 FQPLrDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRI 288
Cdd:cd19081 244 LRIL-DALDEVAAEHGA-TPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEEVARL 307
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
19-288 |
5.00e-30 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 114.27 E-value: 5.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 19 MGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphLRGRMEIVSKCgIATKARaentigh 98
Cdd:cd19138 16 QGTWYMGEDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRG---RRDKVFLVSKV-LPSNAS------- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 99 yitdRDHIVLSAEQSLRNLATDHLDLLLIHRPD--PLmdaDEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQsRLPF-- 174
Cdd:cd19138 85 ----RQGTVRACERSLRRLGTDYLDLYLLHWRGgvPL---AETVAAMEELKKEGKIRAWGVSNFDTDDMEELW-AVPGgg 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 175 TLATNQVEISPVHQPLLLDgTLDQLQQLRIRPMAWSCLGGGRLFNDESFQplRDELAQVAKELNAeSIEQVVYAWILRLP 254
Cdd:cd19138 157 NCAANQVLYNLGSRGIEYD-LLPWCREHGVPVMAYSPLAQGGLLRRGLLE--NPTLKEIAARHGA-TPAQVALAWVLRDG 232
|
250 260 270
....*....|....*....|....*....|....
gi 695764355 255 SQpLPIIGSGKIERVRSAVVAEKMNMSRQQWFRI 288
Cdd:cd19138 233 NV-IAIPKSGSPEHARENAAAADLELTEEDLAEL 265
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
38-289 |
8.70e-29 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 111.55 E-value: 8.70e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHlrgRMEIVskcgIATKARAEntigHYITDRDHIVLSAEQSLRNL 117
Cdd:cd19093 32 FDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGD---RDEVV----IATKFAPL----PWRLTRRSVVKALKASLERL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 118 ATDHLDLLLIHRPDP-LMDADEVAEAFLALHHSGKVRHFGVSNFTPAQF-----TLLQSRLPftLATNQVEISPVHQPLL 191
Cdd:cd19093 101 GLDSIDLYQLHWPGPwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLrrahkALKERGVP--LASNQVEYSLLYRDPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 192 LDGTLDQLQQLRIRPMAWSCLGGGRL-----------------FNDESF---QPLRDELAQVAKELNAeSIEQVVYAWIL 251
Cdd:cd19093 179 QNGLLPACDELGITLIAYSPLAQGLLtgkyspenpppggrrrlFGRKNLekvQPLLDALEEIAEKYGK-TPAQVALNWLI 257
|
250 260 270
....*....|....*....|....*....|....*...
gi 695764355 252 RLPsqPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIR 289
Cdd:cd19093 258 AKG--VVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
15-275 |
1.68e-28 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 110.72 E-value: 1.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGywrLMDWNMSVNERVSF--IEQHLDLGVTTVDHADIYGDY----QCEAAFGEALKQaphlRG-RMEIVskcgIA 87
Cdd:cd19082 1 SRIVLG---TADFGTRIDEEEAFalLDAFVELGGNFIDTARVYGDWvergASERVIGEWLKS----RGnRDKVV----IA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 88 TKAraentiGHYITDRDHI-VLSA-------EQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSN 159
Cdd:cd19082 70 TKG------GHPDLEDMSRsRLSPediradlEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASN 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 160 FTPAqftllqsRL-------------PFTLATNQVEISPVHQPLLLDGTL--------DQLQQLRIRPMAWSCLGGG--- 215
Cdd:cd19082 144 WSTE-------RIaeanayakahglpGFAASSPQWSLARPNEPPWPGPTLvamdeemrAWHEENQLPVFAYSSQARGffs 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695764355 216 ---------------RLFNDESFQpLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19082 217 kraaggaeddselrrVYYSEENFE-RLERAKELAEEKGV-SPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAA 289
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
15-281 |
2.23e-28 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 110.37 E-value: 2.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlrgRMEIVskcgIATKARAen 94
Cdd:cd19074 5 SELSLGTWLTFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWP----RESYV----ISTKVFW-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 95 TIGHYITD----RDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFT---- 166
Cdd:cd19074 75 PTGPGPNDrglsRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAeahd 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 167 LLQSRLPFTLATNQVEISPVHQPlLLDGTLDQLQQLRIRPMAWSCLGGG----------------------------RLF 218
Cdd:cd19074 155 LARQFGLIPPVVEQPQYNMLWRE-IEEEVIPLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednrdkkrRLL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764355 219 NDESFQPLRdELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMS 281
Cdd:cd19074 234 TDENLEKVK-KLKPIADELGL-TLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLS 294
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
19-259 |
2.58e-28 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 108.90 E-value: 2.58e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 19 MGYWRLMDwnmsvNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRgrmeivSKCGIATKARAENTigh 98
Cdd:cd19073 6 LGTWQLRG-----DDCANAVKEALELGYRHIDTAEIYNN---EAEVGEAIAESGVPR------EDLFITTKVWRDHL--- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 99 yitDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLAT 178
Cdd:cd19073 69 ---RPEDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 179 NQVEISPVHQPLLLdgtLDQLQQLRIRPMAWSCLGGGRLFNDEsfqplrdELAQVAKELNAeSIEQVVYAWILRLPSQPL 258
Cdd:cd19073 146 NQVEFHPFLYQAEL---LEYCRENDIVITAYSPLARGEVLRDP-------VIQEIAEKYDK-TPAQVALRWLVQKGIVVI 214
|
.
gi 695764355 259 P 259
Cdd:cd19073 215 P 215
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
29-291 |
3.69e-28 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 110.02 E-value: 3.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 29 MSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphLRGRMEIVSKCGIATkarAENTIGHYITD--RDHI 106
Cdd:cd19078 22 PDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKP---FRDQVVIATKFGFKI---DGGKPGPLGLDsrPEHI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 VLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQF---------TLLQSRLPFTLA 177
Cdd:cd19078 96 RKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVETIrrahavcpvTAVQSEYSMMWR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 178 TNQVEISPVhqpllldgtldqLQQLRIRPMAWSCLGGGRL---------------------FNDESF---QPLRDELAQV 233
Cdd:cd19078 176 EPEKEVLPT------------LEELGIGFVPFSPLGKGFLtgkidentkfdegddraslprFTPEALeanQALVDLLKEF 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 695764355 234 AKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKA 291
Cdd:cd19078 244 AEEKGA-TPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIEDA 300
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
10-277 |
8.35e-27 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 106.57 E-value: 8.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 10 QGPEFSRFVMGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYG--DYQCEAAFGEALKQAPHLRgRMEIVskcgIA 87
Cdd:cd19089 7 SGLHLPAISLGLWHNFGDYTSPEEARELLRTAFDLGITHFDLANNYGppPGSAEENFGRILKRDLRPY-RDELV----IS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 88 TKARAENTIGHYIT--DRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQF 165
Cdd:cd19089 82 TKAGYGMWPGPYGDggSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 166 T----LLQSR-LPFtlATNQVEISpvhqplLLD-----GTLDQLQQLRIRPMAWSCLGGGRL------------------ 217
Cdd:cd19089 162 RraiaLLRELgVPL--IIHQPRYS------LLDrwaedGLLEVLEEAGIGFIAFSPLAQGLLtdkylngippdsrraaes 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695764355 218 -------FNDESFQPLRdELAQVAKElNAESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEK 277
Cdd:cd19089 234 kflteeaLTPEKLEQLR-KLNKIAAK-RGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALK 298
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
27-267 |
1.31e-26 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 106.15 E-value: 1.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKqapHLRGRMEIVSKCGIATKARAENTIGHYitdRDHI 106
Cdd:cd19080 26 WGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIA---GNRDRIVLATKYTMNRRPGDPNAGGNH---RKNL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 VLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNfTPAQF-----TLLQSRLPFTLATNQV 181
Cdd:cd19080 100 RRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISD-TPAWVvaranTLAELRGWSPFVALQI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 182 EISpvhqplLLDGT-----LDQLQQLRIRPMAWSCLGGGRL------------------------FNDESFQpLRDELAQ 232
Cdd:cd19080 179 EYS------LLERTperelLPMARALGLGVTPWSPLGGGLLtgkyqrgeegrageakgvtvgfgkLTERNWA-IVDVVAA 251
|
250 260 270
....*....|....*....|....*....|....*
gi 695764355 233 VAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIE 267
Cdd:cd19080 252 VAEELGR-SAAQVALAWVRQKPGVVIPIIGARTLE 285
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
19-273 |
3.61e-26 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 103.33 E-value: 3.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 19 MGYWRL-MDWNMSVNERVSF--IEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAphlRGRMEIVSKCGiaTKARAENT 95
Cdd:cd19086 8 FGTWGLgGDWWGDVDDAEAIraLRAALDLGINFFDTADVYGDGHSERLLGKALKGR---RDKVVIATKFG--NRFDGGPE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 96 IGHYiTDRDHIVLSAEQSLRNLATDHLDLLLIHRP-DPLMDADEVAEAFLALHHSGKVRHFGVS-NFTPAQFTLLQSRLP 173
Cdd:cd19086 83 RPQD-FSPEYIREAVEASLKRLGTDYIDLYQLHNPpDEVLDNDELFEALEKLKQEGKIRAYGVSvGDPEEALAALRRGGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 174 FTLatnQVEISPVHQPlLLDGTLDQLQQLRI----R-PMAWSCLGGgrlfndesfqplrdELAQVAkelnaesieqvvYA 248
Cdd:cd19086 162 DVV---QVIYNLLDQR-PEEELFPLAEEHGVgviaRvPLASGLLTG--------------KLAQAA------------LR 211
|
250 260
....*....|....*....|....*
gi 695764355 249 WILRLPSQPLPIIGSGKIERVRSAV 273
Cdd:cd19086 212 FILSHPAVSTVIPGARSPEQVEENA 236
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
16-293 |
8.22e-26 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 102.43 E-value: 8.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 16 RFVMGYWRLMDwnmsvNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGrmEIVskcgIATKARAENT 95
Cdd:cd19139 3 AFGLGTFRLKD-----DVVIDSVRTALELGYRHIDTAQIYDN---EAAVGQAIAESGVPRD--ELF----ITTKIWIDNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 96 ighyitDRDHIVLSAEQSLRNLATDHLDLLLIHRPDP--LMDADEVAEAFLALHHSGKVRHFGVSNFTPAQftLLQSRLP 173
Cdd:cd19139 69 ------SKDKLLPSLEESLEKLRTDYVDLTLIHWPSPndEVPVEEYIGALAEAKEQGLTRHIGVSNFTIAL--LDEAIAV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 174 F---TLATNQVEISPVHQPLLLdgtLDQLQQLRIRPMAWSCLGGGRLFNDESfqplrdeLAQVAKELNAeSIEQVVYAWI 250
Cdd:cd19139 141 VgagAIATNQIELSPYLQNRKL---VAHCKQHGIHVTSYMTLAYGKVLDDPV-------LAAIAERHGA-TPAQIALAWA 209
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 695764355 251 LRLPSQPLPiiGSGKIERVRSAVVAEKMNMSRQQWFRIrkAAL 293
Cdd:cd19139 210 MARGYAVIP--SSTKREHLRSNLLALDLTLDADDMAAI--AAL 248
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
18-273 |
8.49e-26 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 102.70 E-value: 8.49e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 18 VMGYWRlMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqCEAAFGEALKQapHLRGRMEIVSKCGiatkARAENTIG 97
Cdd:cd19095 7 TSGIGR-VWGVPSEAEAARLLNTALDLGINLIDTAPAYGR--SEERLGRALAG--LRRDDLFIATKVG----THGEGGRD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 98 HYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAqftllqsrLPFTLA 177
Cdd:cd19095 78 RKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDGEE--------LEAAIA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 178 TN-----QVEISPVHQplLLDGTLDQLQQLRIRPMAWSCLGGGRLFNDESFQPLRDELAQV---AKELNAESIEQVVYAW 249
Cdd:cd19095 150 SGvfdvvQLPYNVLDR--EEEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYARRpefAAEIGGATWAQAALRF 227
|
250 260
....*....|....*....|....
gi 695764355 250 ILRLPSQPLPIIGSGKIERVRSAV 273
Cdd:cd19095 228 VLSHPGVSSAIVGTTNPEHLEENL 251
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
11-284 |
1.99e-25 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 101.88 E-value: 1.99e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRL-----MDWNMSvNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlRGRMEIVSKcg 85
Cdd:cd19137 1 GEKIPALGLGTWGIggfltPDYSRD-EEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFP--REDLFIVTK-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 86 iatkaraentIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQF 165
Cdd:cd19137 76 ----------VWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 166 TLLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRIRPMAWSCLgggrlfnDESFQPLRDELAQVAKELNAeSIEQV 245
Cdd:cd19137 146 EEAISKSQTPIVCNQVKYNLEDRDPERDGLLEYCQKNGITVVAYSPL-------RRGLEKTNRTLEEIAKNYGK-TIAQI 217
|
250 260 270
....*....|....*....|....*....|....*....
gi 695764355 246 VYAWILRLPSQpLPIIGSGKIERVRSAVVAEKMNMSRQQ 284
Cdd:cd19137 218 ALAWLIQKPNV-VAIPKAGRVEHLKENLKATEIKLSEEE 255
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
20-292 |
2.08e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 102.75 E-value: 2.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 20 GYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphLRGRMEIVSKCGIATKAraENTIGHY 99
Cdd:cd19102 14 GGWGGGWGPQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKG---LRDRPIVATKCGLLWDE--EGRIRRS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 100 ItDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPftLATN 179
Cdd:cd19102 89 L-KPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHP--IASL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 180 QVEISPVHQPLLLDgTLDQLQQLRIRPMAWSCLGGGRL------------------FNDESFQP--------LRDELAQV 233
Cdd:cd19102 166 QPPYSLLRRGIEAE-ILPFCAEHGIGVIVYSPMQSGLLtgkmtpervaslpaddwrRRSPFFQEpnlarnlaLVDALRPI 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 695764355 234 AKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKAA 292
Cdd:cd19102 245 AERHGR-TVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEALL 302
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-158 |
4.11e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 100.74 E-value: 4.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 33 ERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphlRGRMEIVskcgIATKARAEntigHYITDRDHIVLSAEQ 112
Cdd:cd19105 26 ESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKG----LRRDKVF----LATKASPR----LDKKDKAELLKSVEE 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 695764355 113 SLRNLATDHLDLLLIH---RPDPLMDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:cd19105 94 SLKRLQTDYIDIYQLHgvdTPEERLLNEELLEALEKLKKEGKVRFIGFS 142
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
27-259 |
1.46e-24 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 99.27 E-value: 1.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQA--PhlrgRMEIVskcgIATKARAentiGHYitDRD 104
Cdd:cd19132 15 YPLKGDEGVEAVVAALQAGYRLLDTAFNYEN---EGAVGEAVRRSgvP----REELF----VTTKLPG----RHH--GYE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 105 HIVLSAEQSLRNLATDHLDLLLIHRPDPLMDA-DEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEI 183
Cdd:cd19132 78 EALRTIEESLYRLGLDYVDLYLIHWPNPSRDLyVEAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVNQIEL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 184 SPVhqpllldgtLDQLQQLR------IRPMAWSCLGGG-RLFNDESfqplrdeLAQVAKELNAeSIEQVVYAWILRLPSQ 256
Cdd:cd19132 158 HPY---------FPQAEQRAyhrehgIVTQSWSPLGRGsGLLDEPV-------IKAIAEKHGK-TPAQVVLRWHVQLGVV 220
|
...
gi 695764355 257 PLP 259
Cdd:cd19132 221 PIP 223
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
15-180 |
3.20e-24 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 99.30 E-value: 3.20e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGYWRLMDW---NMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHlRGRMEIVSKCGIATKAR 91
Cdd:cd19148 5 SRIALGTWAIGGWmwgGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGK-RDRVVIATKVGLEWDEG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 92 aentiGHYITD--RDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQ 169
Cdd:cd19148 84 -----GEVVRNssPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQMETFR 158
|
170
....*....|.
gi 695764355 170 SRLPftLATNQ 180
Cdd:cd19148 159 KVAP--LHTVQ 167
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
42-281 |
6.39e-24 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 98.80 E-value: 6.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDYQCEAAFGEALKQAphlrgRMEIVskcgIATKARAE-----NTIGhyiTDRDHIVLSAEQSLRN 116
Cdd:cd19087 40 LDAGINFFDTADVYGGGRSEEIIGRWIAGR-----RDDIV----LATKVFGPmgddpNDRG---LSRRHIRRAVEASLRR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 117 LATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQ---------------FTLLQSrlPFTLATNQ- 180
Cdd:cd19087 108 LQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQiakaqgiaarrgllrFVSEQP--MYNLLKRQa 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 181 -VEISPVHQ----------PL---LLDGTLDQLQQLRIRPMAWSCLGGGRLFNDESFQPLrDELAQVAKELNaESIEQVV 246
Cdd:cd19087 186 eLEILPAARayglgvipysPLaggLLTGKYGKGKRPESGRLVERARYQARYGLEEYRDIA-ERFEALAAEAG-LTPASLA 263
|
250 260 270
....*....|....*....|....*....|....*
gi 695764355 247 YAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMS 281
Cdd:cd19087 264 LAWVLSHPAVTSPIIGPRTLEQLEDSLAALEITLT 298
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
2-298 |
7.61e-24 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 98.67 E-value: 7.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 2 VQRIAMAPQGPEFSRF---VMGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYqcEAAFGEALKQAPHLRGRM 78
Cdd:cd19144 1 IPTRTLGRNGPSVPALgfgAMGLSAFYGPPKPDEERFAVLDAAFELGCTFWDTADIYGDS--EELIGRWFKQNPGKREKI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 79 EIVSKCGIatKARAENTIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:cd19144 79 FLATKFGI--EKNVETGEYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 159 NFTPAqfTLLQSRLPFTLATNQVEISP----VHQPLLldGTLDQLQQLRIRPMAWSCLGGGRL----------------- 217
Cdd:cd19144 157 ECSAE--TLRRAHAVHPIAAVQIEYSPfsldIERPEI--GVLDTCRELGVAIVAYSPLGRGFLtgairspddfeegdfrr 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 218 ----FNDESFQP---LRDELAQVAKELNAESiEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRK 290
Cdd:cd19144 233 maprFQAENFPKnleLVDKIKAIAKKKNVTA-GQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEIRE 311
|
....*...
gi 695764355 291 AALGYDVP 298
Cdd:cd19144 312 IAEEAEVV 319
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
3-275 |
1.14e-23 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 98.06 E-value: 1.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 3 QRIAMAPQGPEFSRF---VMGywrlMDWN---MSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAphlRG 76
Cdd:cd19076 1 PTRKLGTQGLEVSALglgCMG----MSAFygpADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDR---RD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 77 RMEIVSKCGI----ATKARAENTighyitDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKV 152
Cdd:cd19076 74 EVVIATKFGIvrdpGSGFRGVDG------RPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 153 RHFGVSNFTPAQF---------TLLQSRlpFTLATNQVEispvhqplllDGTLDQLQQLRIRPMAWSCLGGGRL------ 217
Cdd:cd19076 148 RYIGLSEASADTIrrahavhpiTAVQSE--YSLWTRDIE----------DEVLPTCRELGIGFVAYSPLGRGFLtgaiks 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695764355 218 ---------------FNDESFQ---PLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19076 216 pedlpeddfrrnnprFQGENFDknlKLVEKLEAIAAEKGC-TPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGA 290
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
25-275 |
1.17e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 97.79 E-value: 1.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 25 MDWNMSVNERVSF--IEQHLDLGVTTVDHADIYGDY-------QCEAAFGEALKQApHLRGRMEIVSKCGIATKARAENT 95
Cdd:cd19752 8 MYFGTRTDEETSFaiLDRYVAAGGNFLDTANNYAFWteggvggESERLIGRWLKDR-GNRDDVVIATKVGAGPRDPDGGP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 96 IGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTP------------- 162
Cdd:cd19752 87 ESPEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAwrlerarqiarqq 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 163 --AQFTLLQSRlpFT-LATNQVEISPVHQPLlldgTLDQLQQLRIRP----MAWSCLGGGRLFNDEsfQPLRDE------ 229
Cdd:cd19752 167 gwAEFSAIQQR--HSyLRPRPGADFGVQRIV----TDELLDYASSRPdltlLAYSPLLSGAYTRPD--RPLPEQydgpds 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 695764355 230 ------LAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19752 239 darlavLEEVAGELGA-TPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAA 289
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
28-281 |
2.22e-23 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 97.10 E-value: 2.22e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 28 NMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphlRGRMEIVskcgIATKARAENTIGHYITDRDHIV 107
Cdd:cd19083 29 NLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKE----YNRNEVV----IATKGAHKFGGDGSVLNNSPEF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 108 L--SAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFT----------------PAQFTLLQ 169
Cdd:cd19083 101 LrsAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSleqlkeankdgyvdvlQGEYNLLQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 170 SR-----LPFTlATNQVEISPvHQPL---LLDGTLDqlQQLRIRPMAWSCLGGgrLFNDESFQP-LR--DELAQVAKELN 238
Cdd:cd19083 181 REaeediLPYC-VENNISFIP-YFPLasgLLAGKYT--KDTKFPDNDLRNDKP--LFKGERFSEnLDkvDKLKSIADEKG 254
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 695764355 239 AEsIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMS 281
Cdd:cd19083 255 VT-VAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVTLT 296
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
42-293 |
1.21e-22 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 94.32 E-value: 1.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIATKARaentighyitdrDHIVLSAEQSLRNLATDH 121
Cdd:PRK11172 26 LELGYRAIDTAQIYDN---EAAVGQAIAESGVPRDELFITTKIWIDNLAK------------DKLIPSLKESLQKLRTDY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 122 LDLLLIHRPDPlMDADEVAEAFLAL---HHSGKVRHFGVSNFTPAqftLLQSRL----PFTLATNQVEISPVHQPLLLdg 194
Cdd:PRK11172 91 VDLTLIHWPSP-NDEVSVEEFMQALleaKKQGLTREIGISNFTIA---LMKQAIaavgAENIATNQIELSPYLQNRKV-- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 195 tLDQLQQLRIRPMAWSCLGGGRLFNDESfqplrdeLAQVAKELNAeSIEQVVYAWILRLPSQPLPiiGSGKIERVRSAVV 274
Cdd:PRK11172 165 -VAFAKEHGIHVTSYMTLAYGKVLKDPV-------IARIAAKHNA-TPAQVILAWAMQLGYSVIP--SSTKRENLASNLL 233
|
250
....*....|....*....
gi 695764355 275 AEKMNMSRQQWFRIrkAAL 293
Cdd:PRK11172 234 AQDLQLDAEDMAAI--AAL 250
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
11-290 |
5.29e-21 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 90.79 E-value: 5.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMDW----NMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKqapHLRGRMEIVSKCGI 86
Cdd:cd19149 8 GIEASVIGLGTWAIGGGpwwgGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIK---GRRDKVVLATKCGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 87 atkaRAENTIGHYITDRDH-----------IVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHF 155
Cdd:cd19149 85 ----RWDREGGSFFFVRDGvtvyknlspesIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 156 GVSNFTPAQftLLQSRLPFTLATNQVEISpvhqplLLDGTLDQ-----LQQLRIRPMAWSCLGGGRL----FNDESF--Q 224
Cdd:cd19149 161 GASNVSVEQ--IKEYVKAGQLDIIQEKYS------MLDRGIEKellpyCKKNNIAFQAYSPLEQGLLtgkiTPDREFdaG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 225 PLR--------DELAQVAKELNAE---------SIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFR 287
Cdd:cd19149 233 DARsgipwfspENREKVLALLEKWkplcekygcTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLSAEDIAT 312
|
...
gi 695764355 288 IRK 290
Cdd:cd19149 313 MRS 315
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
27-249 |
1.00e-20 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 88.97 E-value: 1.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIATKaraentighyitDRDHI 106
Cdd:cd19131 18 WQVSNDEAASAVREALEVGYRSIDTAAIYGN---EEGVGKAIRASGVPREELFITTKLWNSDQ------------GYDST 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 VLSAEQSLRNLATDHLDLLLIHRPDPLMDA-DEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISP 185
Cdd:cd19131 83 LRAFDESLRKLGLDYVDLYLIHWPVPAQDKyVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIELHP 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764355 186 VHQPlllDGTLDQLQQLRIRPMAWSCLGGGRLFNDESfqplrdeLAQVAKELnAESIEQVVYAW 249
Cdd:cd19131 163 RFQQ---RELRAFHAKHGIQTESWSPLGQGGLLSDPV-------IGEIAEKH-GKTPAQVVIRW 215
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
35-295 |
1.09e-20 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 89.21 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 35 VSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKcgiatkaraentighYITDRDHIVLSAEQSL 114
Cdd:cd19120 28 VDSVKLALKAGFRHIDTAEMYGN---EKEVGEALKESGVPREDLFITTK---------------VSPGIKDPREALRKSL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 115 RNLATDHLDLLLIHRP----DPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQF-TLLQSRlPFTLATNQVEISP---V 186
Cdd:cd19120 90 AKLGVDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLeELLDTA-KIKPAVNQIEFHPylyP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 187 HQPLLLdgtldQLQQLR-IRPMAWSCLGGGRLFNDEsfqPLRDELAQVAKELNAeSIEQVVYAWILrlpSQ-PLPIIGSG 264
Cdd:cd19120 169 QQPALL-----EYCREHgIVVSAYSPLSPLTRDAGG---PLDPVLEKIAEKYGV-TPAQVLLRWAL---QKgIVVVTTSS 236
|
250 260 270
....*....|....*....|....*....|.
gi 695764355 265 KIERVRSAVVAEKMNMSRQQWFRIRKAALGY 295
Cdd:cd19120 237 KEERMKEYLEAFDFELTEEEVEEIDKAGKQK 267
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-243 |
3.48e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 87.58 E-value: 3.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 30 SVNERVSFIEQHLDLGVTTVDHADIYGDyqCEAAFGEALKQAPHLRgrmeIVSKCGIATKARAEntighyitDRDHIVLS 109
Cdd:cd19097 24 SEKEAKKILEYALKAGINTLDTAPAYGD--SEKVLGKFLKRLDKFK----IITKLPPLKEDKKE--------DEAAIEAS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 110 AEQSLRNLATDHLDLLLIHRP-DPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLAtnQVEISPVHQ 188
Cdd:cd19097 90 VEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDII--QLPFNILDQ 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764355 189 PLLLDGTLDQLQQLRIRPMAWSCLGGGRLFND--------ESFQPLRDELAQVAKELNAESIE 243
Cdd:cd19097 168 RFLKSGLLAKLKKKGIEIHARSVFLQGLLLMEpdklpakfAPAKPLLKKLHELAKKLGLSPLE 230
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
43-275 |
8.15e-20 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 87.46 E-value: 8.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 43 DLGVTTVDHADIYGDY--QCEAAFGEALKQapHLRG-RMEIVskcgIATKAraentiGHYITD--------RDHIVLSAE 111
Cdd:cd19151 41 DLGITHFDLANNYGPPpgSAEENFGRILKE--DLKPyRDELI----ISTKA------GYTMWPgpygdwgsKKYLIASLD 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 112 QSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQ----FTLLQSrlpftLATNQVeispVH 187
Cdd:cd19151 109 QSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEEareaAAILKD-----LGTPCL----IH 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 188 QP-------LLLDGTLDQLQQLRIRPMAWSCLGGGRLFN--------------DESF----QPLRDELAQVaKELNA--- 239
Cdd:cd19151 180 QPkysmfnrWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDrylngipedsraakGSSFlkpeQITEEKLAKV-RRLNEiaq 258
|
250 260 270
....*....|....*....|....*....|....*....
gi 695764355 240 ---ESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19151 259 argQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGA 297
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
30-249 |
1.90e-19 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 85.54 E-value: 1.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 30 SVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCgiatkaraentighYITD--RDHIV 107
Cdd:cd19127 20 PPEETADAVATALADGYRLIDTAAAYGN---EREVGEGIRRSGVDRSDIFVTTKL--------------WISDygYDKAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 108 LSAEQSLRNLATDHLDLLLIHRPDPlMDADEVAEAFLALHH---SGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEIS 184
Cdd:cd19127 83 RGFDASLRRLGLDYVDLYLLHWPVP-NDFDRTIQAYKALEKllaEGRVRAIGVSNFTPEHLERLIDATTVVPAVNQVELH 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 185 PVH-QPLLLDGTldqlQQLRIRPMAWSCLGGGRLF----NDESFQPLRDELAQVAKELNAESIEQVVYAW 249
Cdd:cd19127 162 PYFsQKDLRAFH----RRLGIVTQAWSPIGGVMRYgasgPTGPGDVLQDPTITGLAEKYGKTPAQIVLRW 227
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
42-164 |
2.22e-19 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 86.07 E-value: 2.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRgrmeivskcgIATKARAENTIGHyitDRDHIVLSAEQSLRNLATDH 121
Cdd:cd19075 30 LERGHTEIDTARVYPDGTSEELLGELGLGERGFK----------IDTKANPGVGGGL---SPENVRKQLETSLKRLKVDK 96
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 695764355 122 LDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQ 164
Cdd:cd19075 97 VDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWE 139
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-273 |
5.05e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 84.07 E-value: 5.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMdwNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqCEAAFGEALKqapHLRGRMEIVSKCGIATKA 90
Cdd:cd19100 8 GLKVSRLGFGGGPLG--RLSQEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALK---GRRDKVFLATKTGARDYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 91 RAENTIghyitdrdhivlsaEQSLRNLATDHLDLLLIH------RPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQ 164
Cdd:cd19100 81 GAKRDL--------------ERSLKRLGTDYIDLYQLHavdteeDLDQVFGPGGALEALLEAKEEGKIRFIGISGHSPEV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 165 FTLLQSRLPFtlATNQVEISPV--HQPLLLDGTLDQLQQLRI-----RPMawsclGGGRLFNDesfqplrdelaqvakel 237
Cdd:cd19100 147 LLRALETGEF--DVVLFPINPAgdHIDSFREELLPLAREKGVgviamKVL-----AGGRLLSG----------------- 202
|
250 260 270
....*....|....*....|....*....|....*.
gi 695764355 238 NAESIEQVVyAWILRLPSQPLPIIGSGKIERVRSAV 273
Cdd:cd19100 203 DPLDPEQAL-RYALSLPPVDVVIVGMDSPEELDENL 237
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
42-251 |
1.17e-18 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 83.39 E-value: 1.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIaTKARAENTIghyitdrdhivLSAEQSLRNLATDH 121
Cdd:cd19133 33 IKAGYRLIDTAAAYGN---EEAVGRAIKKSGIPREELFITTKLWI-QDAGYEKAK-----------KAFERSLKRLGLDY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 122 LDLLLIHRPdplmdADEVAEAFLA---LHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPlllDGTLDQ 198
Cdd:cd19133 98 LDLYLIHQP-----FGDVYGAWRAmeeLYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPFNQQ---IEAVEF 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 695764355 199 LQQLRIRPMAWSCLGGGR--LFNDEsfqplrdELAQVAKELNaESIEQVVYAWIL 251
Cdd:cd19133 170 LKKYGVQIEAWGPFAEGRnnLFENP-------VLTEIAEKYG-KSVAQVILRWLI 216
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
42-292 |
8.04e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 81.61 E-value: 8.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlrgRMEIVskcgIATKARAenTIGHYITDRdhIVLSAEQSLRNLATDH 121
Cdd:cd19103 42 MAAGLNLWDTAAVYGMGASEKILGEFLKRYP----REDYI----ISTKFTP--QIAGQSADP--VADMLEGSLARLGTDY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 122 LDLLLIHRPdplMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSrlpfTLATNQVEISPV--HQPLLL-----DG 194
Cdd:cd19103 110 IDIYWIHNP---ADVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANE----ILAKAGVSLSAVqnHYSLLYrsseeAG 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 195 TLDQLQQLRIRPMAWSCL-----------------GGGRLfndESFQPLRDELA---QVAKELNAE---SIEQVVYAW-I 250
Cdd:cd19103 183 ILDYCKENGITFFAYMVLeqgalsgkydtkhplpeGSGRA---ETYNPLLPQLEeltAVMAEIGAKhgaSIAQVAIAWaI 259
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 695764355 251 LRlpsQPLPIIGSGKIERVRSAVVAEKMNMSRQQWFRIRKAA 292
Cdd:cd19103 260 AK---GTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQLA 298
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
38-253 |
2.53e-17 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 79.60 E-value: 2.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRG--RMEIVskcgIATKaraentighyITDRDHIVLSA----E 111
Cdd:cd19136 21 VDAALKAGYRLIDTASVYRN---EADIGKALRDLLPKYGlsREDIF----ITSK----------LAPKDQGYEKAraacL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 112 QSLRNLATDHLDLLLIHRPDP-LMDAD---------EVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQV 181
Cdd:cd19136 84 GSLERLGTDYLDLYLIHWPGVqGLKPSdprnaelrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAVNQV 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764355 182 EispvHQPLLLDGTLDQL-QQLRIRPMAWSCLGGGRLfndesfQPLRDEL-AQVAKELNaESIEQVVYAWILRL 253
Cdd:cd19136 164 E----FHPHLVQKELLKFcKDHGIHLQAYSSLGSGDL------RLLEDPTvLAIAKKYG-RTPAQVLLRWALQQ 226
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-275 |
2.42e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 77.63 E-value: 2.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 13 EFSRFVMGYWRL--MDWN-MSVNERVSFIEQHLDLGVTTVDHADIYGDyqCEAAFGEALKQaphLRGRMEIVSKCGIATK 89
Cdd:cd19101 1 TISRVINGMWQLsgGHGGiRDEDAAVRAMAAYVDAGLTTFDCADIYGP--AEELIGEFRKR---LRRERDAADDVQIHTK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 90 A---RAENTIghyitDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDA-DEVAEAFLALHHSGKVRHFGVSNF-TPAQ 164
Cdd:cd19101 76 WvpdPGELTM-----TRAYVEAAIDRSLKRLGVDRLDLVQFHWWDYSDPGyLDAAKHLAELQEEGKIRHLGLTNFdTERL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 165 FTLLQSRLPftLATNQVEIS-----PVHQ----------PLLLDGT----------LDQLQQLRIRPMAWScLGGGRLFN 219
Cdd:cd19101 151 REILDAGVP--IVSNQVQYSlldrrPENGmaalcedhgiKLLAYGTlaggllsekyLGVPEPTGPALETRS-LQKYKLMI 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764355 220 DES-----FQPLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19101 228 DEWggwdlFQELLRTLKAIADKHGV-SIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRA 287
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-158 |
3.58e-16 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 77.31 E-value: 3.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 33 ERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQaphLRGRMEIVSKCGIATKARaeNTIGhyitdrDHIVLSAEQ 112
Cdd:cd19104 33 EQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKG---LPAGPYITTKVRLDPDDL--GDIG------GQIERSVEK 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764355 113 SLRNLATDHLDLLLIH------RPDPL---------MDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:cd19104 102 SLKRLKRDSVDLLQLHnrigdeRDKPVggtlsttdvLGLGGVADAFERLRSEGKIRFIGIT 162
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
38-221 |
8.65e-16 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 75.33 E-value: 8.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKcgiatkaraentIGHYITDRDHIVLSAEQSLRNL 117
Cdd:cd19130 29 VATALEVGYRHIDTAAIYGN---EEGVGAAIAASGIPRDELFVTTK------------LWNDRHDGDEPAAAFAESLAKL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 118 ATDHLDLLLIHRPDPLMDA-DEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQplllDGTL 196
Cdd:cd19130 94 GLDQVDLYLVHWPTPAAGNyVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHPAYQ----QRTI 169
|
170 180
....*....|....*....|....*.
gi 695764355 197 DQLQQLR-IRPMAWSCLGGGRLFNDE 221
Cdd:cd19130 170 RDWAQAHdVKIEAWSPLGQGKLLGDP 195
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
29-284 |
9.53e-16 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 76.02 E-value: 9.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 29 MSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQApHLRGRMEIVSKCGIATKA------RAENTIGHYitd 102
Cdd:cd19147 31 MDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSR-KNRDQIVIATKFTTDYKAyevgkgKAVNYCGNH--- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 103 RDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNfTPA-------QFTLLQSRLPFT 175
Cdd:cd19147 107 KRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSD-TPAwvvsaanYYATAHGKTPFS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 176 LATNQVEIspvhqpllldgtLDQLQQLRIRPMA---------WSCLGGGRLF----------NDESFQPLR--------- 227
Cdd:cd19147 186 VYQGRWNV------------LNRDFERDIIPMArhfgmalapWDVLGGGKFQskkaveerkkNGEGLRSFVggteqtpee 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764355 228 ----DELAQVAKELNAESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQ 284
Cdd:cd19147 254 vkisEALEKVAEEHGTESVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEE 314
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
38-273 |
4.28e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 74.28 E-value: 4.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRG--RMEIVskcgIATKA-----------RAENTIGHYI---- 100
Cdd:cd19099 27 LKAALDSGINVIDTAINYRGGRSERLIGKALRELIEKGGikRDEVV----IVTKAgyipgdgdeplRPLKYLEEKLgrgl 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 101 ---TDRDH---------IVLSAEQSLRNLATDHLDLLLIHRP-------DPLMDADEVAEAFLALH---HSGKVRHFGVS 158
Cdd:cd19099 103 idvADSAGlrhcispayLEDQIERSLKRLGLDTIDLYLLHNPeeqllelGEEEFYDRLEEAFEALEeavAEGKIRYYGIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 159 NFTPA---------------------------QFTLLQsrLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRIRPMAWSC 211
Cdd:cd19099 183 TWDGFrappalpghlsleklvaaaeevggdnhHFKVIQ--LPLNLLEPEALTEKNTVKGEALSLLEAAKELGLGVIASRP 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695764355 212 LGGGRLFNdesfqplRDELAQVAKELNAESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAV 273
Cdd:cd19099 261 LNQGQLLG-------ELRLADLLALPGGATLAQRALQFARSTPGVDSALVGMRRPEHVDENL 315
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
51-218 |
6.70e-15 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 73.07 E-value: 6.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 51 HADIYGDYQCEAAFGEALKQAPHL---RGRMEIVskcgIATKARAENTighyitDRDHIVLSAEQSLRNLATDHLDLLLI 127
Cdd:cd19124 36 HFDTAAAYGTEEALGEALAEALRLglvKSRDELF----VTSKLWCSDA------HPDLVLPALKKSLRNLQLEYVDLYLI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 128 HRP---------------DPL-MDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHqpll 191
Cdd:cd19124 106 HWPvslkpgkfsfpieeeDFLpFDIKGVWEAMEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAW---- 181
|
170 180 190
....*....|....*....|....*....|....
gi 695764355 192 ldgtldQLQQLR-------IRPMAWSCLGGGRLF 218
Cdd:cd19124 182 ------QQKKLRefckangIHVTAYSPLGAPGTK 209
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
11-249 |
7.54e-15 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 72.94 E-value: 7.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMDWNMSVNErvsfIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIATKA 90
Cdd:cd19156 6 GVEMPRLGLGVWRVQDGAEAENA----VKWAIEAGYRHIDTAAIYKN---EEGVGQGIRESGVPREEVFVTTKLWNSDQG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 91 RaENTIGHYitdrdhivlsaEQSLRNLATDHLDLLLIHRP--DPLMDAdevAEAFLALHHSGKVRHFGVSNFTPAQFTLL 168
Cdd:cd19156 79 Y-ESTLAAF-----------EESLEKLGLDYVDLYLIHWPvkGKFKDT---WKAFEKLYKEKKVRAIGVSNFHEHHLEEL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 169 QSRLPFTLATNQVEIspvhQPLLLDGTLDQ-LQQLRIRPMAWSCLGGGRLFNDEsfqplrdELAQVAKELNaESIEQVVY 247
Cdd:cd19156 144 LKSCKVAPMVNQIEL----HPLLTQEPLRKfCKEKNIAVEAWSPLGQGKLLSNP-------VLKAIGKKYG-KSAAQVII 211
|
..
gi 695764355 248 AW 249
Cdd:cd19156 212 RW 213
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
27-281 |
8.00e-15 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 73.21 E-value: 8.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyQCE--AAFGEALKQAPHLRGRMEIVSKCGIATKARAEntighyitdrd 104
Cdd:cd19123 20 WKSKPGEVGQAVKQALEAGYRHIDCAAIYGN-EAEigAALAEVFKEGKVKREDLWITSKLWNNSHAPED----------- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 105 hiVLSA-EQSLRNLATDHLDLLLIHRP--------------DPLMDADEVAE----AFLALHHSGKVRHFGVSNFTPAQF 165
Cdd:cd19123 88 --VLPAlEKTLADLQLDYLDLYLMHWPvalkkgvgfpesgeDLLSLSPIPLEdtwrAMEELVDKGLCRHIGVSNFSVKKL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 166 TLL--QSRLPftLATNQVEISP-VHQPLLLDGTLDQlqqlRIRPMAWSCLGGG---RLFNDESFQPLRDE--LAQVAKEL 237
Cdd:cd19123 166 EDLlaTARIK--PAVNQVELHPyLQQPELLAFCRDN----GIHLTAYSPLGSGdrpAAMKAEGEPVLLEDpvINKIAEKH 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 695764355 238 NAeSIEQVVYAWILRLPSQPLPiiGSGKIERVRSAVVAEKMNMS 281
Cdd:cd19123 240 GA-SPAQVLIAWAIQRGTVVIP--KSVNPERIQQNLEAAEVELD 280
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
15-275 |
8.33e-15 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 73.40 E-value: 8.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGIATKARAEN 94
Cdd:cd19143 14 SALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVSTKIFWGGGGPPPN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 95 TIGhyiTDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFT-------- 166
Cdd:cd19143 94 DRG---LSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEeaheiadr 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 167 ---------------LLQSRLpftlatnQVEISPVHQPLLLDGTLdqlqqlrirpmaWSCLGGGRL-------------F 218
Cdd:cd19143 171 lglippvmeqpqynlFHRERV-------EVEYAPLYEKYGLGTTT------------WSPLASGLLtgkynngipegsrL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764355 219 NDESFQPLR--------------DELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19143 232 ALPGYEWLKdrkeelgqekiekvRKLKPIAEELGC-SLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKA 301
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
43-270 |
1.52e-14 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 71.97 E-value: 1.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 43 DLGVTTVDHADIYGdyqCEAAFGEALKQAPHLRGRMEIVSK-----CGiatkarAENTIGhyitdrdhivlSAEQSLRNL 117
Cdd:cd19135 37 ECGYRHIDTAKRYG---CEELLGKAIKESGVPREDLFLTTKlwpsdYG------YESTKQ-----------AFEASLKRL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 118 ATDHLDLLLIHRPDPLMDADEVAEAFLA-------LHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPL 190
Cdd:cd19135 97 GVDYLDLYLLHWPDCPSSGKNVKETRAEtwraleeLYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFHPFQNPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 191 LLdgtLDQLQQLRIRPMAWSCLGGGRLFNDESFQplrdELAQVAKELNAesieQVVYAWILRLPSQPLPiiGSGKIERVR 270
Cdd:cd19135 177 EL---IEYCRDNNIVFEGYCPLAKGKALEEPTVT----ELAKKYQKTPA----QILIRWSIQNGVVTIP--KSTKEERIK 243
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
11-249 |
2.03e-14 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 71.31 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMDWNmsvnERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRgrmeivSKCGIATKA 90
Cdd:cd19126 6 GTRMPWLGLGVFQTPDGD----ETERAVQTALENGYRSIDTAAIYKN---EEGVGEAIRESGVPR------EELFVTTKL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 91 RAENTighyitdRDHIVLSA-EQSLRNLATDHLDLLLIHRP--DPLMDADEVAEAFLAlhhSGKVRHFGVSNFTPAQFTL 167
Cdd:cd19126 73 WNDDQ-------RARRTEDAfQESLDRLGLDYVDLYLIHWPgkDKFIDTWKALEKLYA---SGKVKAIGVSNFQEHHLEE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 168 LQSRLPFTLATNQVEISP-VHQPLLldgtLDQLQQLRIRPMAWSCLGGGRLFNDESfqplrdeLAQVAKELNaESIEQVV 246
Cdd:cd19126 143 LLAHADVVPAVNQVEFHPyLTQKEL----RGYCKSKGIVVEAWSPLGQGGLLSNPV-------LAAIGEKYG-KSAAQVV 210
|
...
gi 695764355 247 YAW 249
Cdd:cd19126 211 LRW 213
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
11-158 |
2.48e-14 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 72.54 E-value: 2.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMDWNMSVNERVsfIEQHLDLGVTTVDHADIYGDyqCEAAFGEALKqapHLRGRMEIVSKCGIATKA 90
Cdd:COG1453 10 GLEVSVLGFGGMRLPRKDEEEAEAL--IRRAIDNGINYIDTARGYGD--SEEFLGKALK---GPRDKVILATKLPPWVRD 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764355 91 RAentighyitDRDHIVlsaEQSLRNLATDHLDLLLIHRPDPL------MDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:COG1453 83 PE---------DMRKDL---EESLKRLQTDYIDLYLIHGLNTEedlekvLKPGGALEALEKAKAEGKIRHIGFS 144
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
11-249 |
4.48e-14 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 70.50 E-value: 4.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 11 GPEFSRFVMGYWRLMDWNMSVNErvsfIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIATKA 90
Cdd:cd19157 7 GVKMPWLGLGVFKVEEGSEVVNA----VKTALKNGYRSIDTAAIYGN---EEGVGKGIKESGIPREELFITSKVWNADQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 91 RaENTIGHYitdrdhivlsaEQSLRNLATDHLDLLLIHRPDPLMDAdEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQS 170
Cdd:cd19157 80 Y-DSTLKAF-----------EASLERLGLDYLDLYLIHWPVKGKYK-ETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 171 RLPFTLATNQVEISP--VHQPLlldgtLDQLQQLRIRPMAWSCLGGGRLFNDESfqplrdeLAQVAKELNaESIEQVVYA 248
Cdd:cd19157 147 DAEIVPMVNQVEFHPrlTQKEL-----RDYCKKQGIQLEAWSPLMQGQLLDNPV-------LKEIAEKYN-KSVAQVILR 213
|
.
gi 695764355 249 W 249
Cdd:cd19157 214 W 214
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
19-290 |
5.70e-14 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 71.17 E-value: 5.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 19 MGYWRLMDWNMSVNERVSFIEQHLDLGVTTVDHADIYGDY--QCEAAFGEALKQ--APHlrgRMEIVskcgIATKARAEN 94
Cdd:PRK09912 30 LGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPpgSAEENFGRLLREdfAAY---RDELI----ISTKAGYDM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 95 TIGHYIT--DRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFT-----L 167
Cdd:PRK09912 103 WPGPYGSggSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQkmvelL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 168 LQSRLPFTlatnqveispVHQPL--LLD------GTLDQLQQ-----LRIRPMAWSCLGGG------------------- 215
Cdd:PRK09912 183 REWKIPLL----------IHQPSynLLNrwvdksGLLDTLQNngvgcIAFTPLAQGLLTGKylngipqdsrmhregnkvr 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 216 ----RLFNDESFQPLR--DELAQVakelNAESIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVA-EKMNMSRQQWFRI 288
Cdd:PRK09912 253 gltpKMLTEANLNSLRllNEMAQQ----RGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQAlNNLTFSTEELAQI 328
|
..
gi 695764355 289 RK 290
Cdd:PRK09912 329 DQ 330
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
41-252 |
1.13e-13 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 69.75 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 41 HLDLgvttvdhADIYGDyQCE--AAFGEALKQAPHL-RGRMEIVSKcgiatkarAENTiGHyitDRDHIVLSAEQSLRNL 117
Cdd:cd19118 36 HLDL-------AKVYQN-QHEvgQALKELLKEEPGVkREDLFITSK--------LWNN-SH---RPEYVEPALDDTLKEL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 118 ATDHLDLLLIHRP------------------DPLMDAD------EVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLP 173
Cdd:cd19118 96 GLDYLDLYLIHWPvafkptgdlnpltavptnGGEVDLDlsvslvDTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 174 FTLATNQVEISPVhqpLLLDGTLDQLQQLRIRPMAWSCLGggrlfNDESFQPL---RDELAQVAKELNaESIEQVVYAWI 250
Cdd:cd19118 176 VVPAVNQIEAHPL---LLQDELVDYCKSKNIHITAYSPLG-----NNLAGLPLlvqHPEVKAIAAKLG-KTPAQVLIAWG 246
|
..
gi 695764355 251 LR 252
Cdd:cd19118 247 IQ 248
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
19-271 |
1.60e-13 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 69.11 E-value: 1.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 19 MGYWRLMDwnmSVNERVsfIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKcgIATKARAentigh 98
Cdd:cd19134 16 LGVGELSD---DEAERS--VSAALEAGYRLIDTAAAYGN---EAAVGRAIAASGIPRGELFVTTK--LATPDQG------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 99 YITDRDhivlSAEQSLRNLATDHLDLLLIHRPDPlmDADEVAEAF---LALHHSGKVRHFGVSNFTPAQFTLLQSRLPFT 175
Cdd:cd19134 80 FTASQA----ACRASLERLGLDYVDLYLIHWPAG--REGKYVDSWgglMKLREEGLARSIGVSNFTAEHLENLIDLTFFT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 176 LATNQVEIspvhQPLLLDGTLDQLQ-QLRIRPMAWSCLGGGRLFNDESFQPLRDELAQVAKelnaesieQVVYAWILRLP 254
Cdd:cd19134 154 PAVNQIEL----HPLLNQAELRKVNaQHGIVTQAYSPLGVGRLLDNPAVTAIAAAHGRTPA--------QVLLRWSLQLG 221
|
250
....*....|....*..
gi 695764355 255 SQPLPiiGSGKIERVRS 271
Cdd:cd19134 222 NVVIS--RSSNPERIAS 236
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
27-232 |
3.73e-13 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 68.18 E-value: 3.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIATKARAENTIghyitdrdhi 106
Cdd:PRK11565 23 WQASNEEVITAIHKALEVGYRSIDTAAIYKN---EEGVGKALKEASVAREELFITTKLWNDDHKRPREAL---------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 vlsaEQSLRNLATDHLDLLLIHRPDPLMDAD-EVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISP 185
Cdd:PRK11565 90 ----EESLKKLQLDYVDLYLMHWPVPAIDHYvEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHP 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 695764355 186 vhqpllldgtLDQLQQLR-------IRPMAWSCL--GGGRLFNdesfQPLRDELAQ 232
Cdd:PRK11565 166 ----------LMQQRQLHawnathkIQTESWSPLaqGGKGVFD----QKVIRDLAD 207
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
42-158 |
3.86e-13 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 67.96 E-value: 3.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDyqCEAAFGEALKQAPhlrgRMEIVskcgIATKARAENTiGHYITDRDHIVLSAEQSLRNLATDH 121
Cdd:cd19090 30 LDLGINYIDTAPAYGD--SEERLGLALAELP----REPLV----LSTKVGRLPE-DTADYSADRVRRSVEESLERLGRDR 98
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 695764355 122 LDLLLIHRPD-----PLMDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:cd19090 99 IDLLMIHDPErvpwvDILAPGGALEALLELKEEGLIKHIGLG 140
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
27-270 |
3.88e-13 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 68.28 E-value: 3.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTtvdHADIYGDYQCEAAFGEALKQAphlrgrmeivSKCGIATKARAENTIGHYITDRDHI 106
Cdd:cd19112 19 WRMEPGEIKELILNAIKIGYR---HFDCAADYKNEKEVGEALAEA----------FKTGLVKREDLFITTKLWNSDHGHV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 VLSAEQSLRNLATDHLDLLLIHRP-----------DPLMDADEVAEAFLA------------LHHSGKVRHFGVSNFtPA 163
Cdd:cd19112 86 IEACKDSLKKLQLDYLDLYLVHFPvatkhtgvgttGSALGEDGVLDIDVTislettwhamekLVSAGLVRSIGISNY-DI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 164 QFT---LLQSRL-PftlATNQVEISPVHQPlllDGTLDQLQQLRIRPMAWSCLGGGrLFNDESF---QPLRDELAQVAKE 236
Cdd:cd19112 165 FLTrdcLAYSKIkP---AVNQIETHPYFQR---DSLVKFCQKHGISVTAHTPLGGA-AANAEWFgsvSPLDDPVLKDLAK 237
|
250 260 270
....*....|....*....|....*....|....
gi 695764355 237 LNAESIEQVVYAWILRLPSQPLPiiGSGKIERVR 270
Cdd:cd19112 238 KYGKSAAQIVLRWGIQRNTAVIP--KSSKPERLK 269
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
27-259 |
5.30e-13 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 67.91 E-value: 5.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPH---LRgRMEIVskcgIATKARaenTIGHYITDR 103
Cdd:cd19111 12 YQSPPEEVRAAVDYALFVGYRHIDTALSYQN---EKAIGEALKWWLKngkLK-REEVF----ITTKLP---PVYLEFKDT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 104 DHivlSAEQSLRNLATDHLDLLLIHRP-------DPLM------DADEVAEAFLALHHSGKVRHFGVSNFTPAQFT--LL 168
Cdd:cd19111 81 EK---SLEKSLENLKLPYVDLYLIHHPcgfvnkkDKGErelassDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINkiLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 169 QSRLPftLATNQVEISPVHQPLLLdgtLDQLQQLRIRPMAWSCLGGGRLFNDESFQPLRDELA-----QVAKELNaESIE 243
Cdd:cd19111 158 YAKVK--PSNLQLECHAYLQQREL---RKFCNKKNIVVTAYAPLGSPGRANQSLWPDQPDLLEdptvlAIAKELD-KTPA 231
|
250
....*....|....*.
gi 695764355 244 QVVYAWILRLPSQPLP 259
Cdd:cd19111 232 QVLLRFVLQRGTGVLP 247
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
15-158 |
7.06e-13 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 67.20 E-value: 7.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 15 SRFVMGYWRL-MDWNMSVNER--VSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlRGRMEIVSKCGIATKAR 91
Cdd:cd19096 1 SVLGFGTMRLpESDDDSIDEEkaIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGP--REKFYLATKLPPWSVKS 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695764355 92 AENTIGHYitdrdhivlsaEQSLRNLATDHLDLLLIH---RPD--PLMDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:cd19096 79 AEDFRRIL-----------EESLKRLGVDYIDFYLLHglnSPEwlEKARKGGLLEFLEKAKKEGLIRHIGFS 139
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
4-162 |
1.19e-12 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 67.07 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 4 RIAMAPQGPEFSRFVMGYWRLMDW---NMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlRGRMEI 80
Cdd:cd19145 2 RVKLGSQGLEVSAQGLGCMGLSGDygaPKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDGP--REKVQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 81 VSKCGIATkarAENTIGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNF 160
Cdd:cd19145 80 ATKFGIHE---IGGSGVEVRGDPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEA 156
|
..
gi 695764355 161 TP 162
Cdd:cd19145 157 SA 158
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
42-281 |
1.54e-12 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 66.71 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDY--QCEAAFGEALKQ--APHlrgRMEIVskcgIATKARAENTIGHYIT--DRDHIVLSAEQSLR 115
Cdd:cd19150 40 FDLGITHFDLANNYGPPpgSAEENFGRILREdfAGY---RDELI----ISTKAGYDMWPGPYGEwgSRKYLLASLDQSLK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 116 NLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPA---QFTLLQSRLPFTLATNQVEISPVHQPLLL 192
Cdd:cd19150 113 RMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPErtrEAAAILRELGTPLLIHQPSYNMLNRWVEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 193 DGTLDQLQQLRIRPMAWSCLG--------------GGRLFNDESFQP---LRDELAQVaKELNA------ESIEQVVYAW 249
Cdd:cd19150 193 SGLLDTLQELGVGCIAFTPLAqglltdkylngipeGSRASKERSLSPkmlTEANLNSI-RALNEiaqkrgQSLAQMALAW 271
|
250 260 270
....*....|....*....|....*....|...
gi 695764355 250 ILRLPSQPLPIIGSGKIERVRSAVVA-EKMNMS 281
Cdd:cd19150 272 VLRDGRVTSALIGASRPEQLEENVGAlDNLTFS 304
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
38-284 |
2.58e-12 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 65.62 E-value: 2.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDYQ-CEAAFGEALKQAPHLRGRMEIVSKCGiATKARAENTighyitdRDHIVLSaeqsLRN 116
Cdd:cd19128 20 VKNAIKAGYRHIDCAYYYGNEAfIGIAFSEIFKDGGVKREDLFITSKLW-PTMHQPENV-------KEQLLIT----LQD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 117 LATDHLDLLLIHRP---DPLMDAD----------------EVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLA 177
Cdd:cd19128 88 LQLEYLDLFLIHWPlafDMDTDGDprddnqiqslskkpleDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 178 TNQVEISPVHQPlllDGTLDQLQQLRIRPMAWSCLGGGRLFNDESFQPLrDELAQVAKELNAeSIEQVVYAWIL-RLPSQ 256
Cdd:cd19128 168 MNQIECHPYFQN---DKLIKFCIENNIHVTAYRPLGGSYGDGNLTFLND-SELKALATKYNT-TPPQVIIAWHLqKWPKN 242
|
250 260
....*....|....*....|....*...
gi 695764355 257 PLPIIGSGKIERVRSAVVAEKMNMSRQQ 284
Cdd:cd19128 243 YSVIPKSANKSRCQQNFDINDLALTKED 270
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
25-162 |
3.19e-12 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 66.05 E-value: 3.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 25 MDWNMSVNERVSFiEQ---HLDLGVTTVDHADIY-----GDYQ--CEAAFGEALKQAPhlrGRMEIVskcgIATKARAEN 94
Cdd:cd19094 9 MTWGEQNTEAEAH-EQldyAFDEGVNFIDTAEMYpvppsPETQgrTEEIIGSWLKKKG---NRDKVV----LATKVAGPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 95 TIGHYIT------DRDHIVLSAEQSLRNLATDHLDLLLIHRPD---PLMDA---------------DEVAEAFLALHHSG 150
Cdd:cd19094 81 EGITWPRgggtrlDRENIREAVEGSLKRLGTDYIDLYQLHWPDrytPLFGGgyytepseeedsvsfEEQLEALGELVKAG 160
|
170
....*....|..
gi 695764355 151 KVRHFGVSNFTP 162
Cdd:cd19094 161 KIRHIGLSNETP 172
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
44-281 |
4.61e-12 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 64.99 E-value: 4.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 44 LGVTTVDHADIYGDYQCEAAFGEALkqAPHlRGRMEIVSKCGiATkaRAENtiGHYITDR--DHIVLSAEQSLRNLATDH 121
Cdd:PRK10376 52 LGVNHIDTSDFYGPHVTNQLIREAL--HPY-PDDLTIVTKVG-AR--RGED--GSWLPAFspAELRRAVHDNLRNLGLDV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 122 LDLL------LIHRPDPlmdaDEVAEAFLAL---HHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQplll 192
Cdd:PRK10376 124 LDVVnlrlmgDGHGPAE----GSIEEPLTVLaelQRQGLVRHIGLSNVTPTQVAEARKIAEIVCVQNHYNLAHRAD---- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 193 DGTLDQLQQLRIRPMAWSCLGGgrlfndesFQPLR-DELAQVAKELNAESIeQVVYAWILRLPSQPLPIIGSGKIERVRS 271
Cdd:PRK10376 196 DALIDALARDGIAYVPFFPLGG--------FTPLQsSTLSDVAASLGATPM-QVALAWLLQRSPNILLIPGTSSVAHLRE 266
|
250
....*....|
gi 695764355 272 AVVAEKMNMS 281
Cdd:PRK10376 267 NLAAAELVLS 276
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
49-271 |
5.59e-12 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 64.67 E-value: 5.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 49 VDHADIYGDyqcEAAFGEALKQA--PHLRGRMEIVskcgIATKARAENTighyitDRDHIVLSAEQSLRNLATDHLDLLL 126
Cdd:cd19125 41 IDCAAIYGN---EKEIGKALKKLfeDGVVKREDLF----ITSKLWCTDH------APEDVPPALEKTLKDLQLDYLDLYL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 127 IHRP------DPLMDADEVAE--------AFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEISPVHQPlll 192
Cdd:cd19125 108 IHWPvrlkkgAHMPEPEEVLPpdipstwkAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQVECHPGWQQ--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 193 DGTLDQLQQLRIRPMAWSCLG-GGRLFNDESFqpLRDE-LAQVAKELNaESIEQVVYAWILRLPSQPLPiiGSGKIERVR 270
Cdd:cd19125 185 DKLHEFCKSKGIHLSAYSPLGsPGTTWVKKNV--LKDPiVTKVAEKLG-KTPAQVALRWGLQRGTSVLP--KSTNEERIK 259
|
.
gi 695764355 271 S 271
Cdd:cd19125 260 E 260
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
74-284 |
9.14e-12 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 64.18 E-value: 9.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 74 LRGRMEIVSKCGIATKARAENTIGHYITDRDHIVLSAEQSLRNLA-TDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKV 152
Cdd:cd19077 64 FRKYPEYADKVVLSVKGGLDPDTLRPDGSPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 153 RHFGVSNFTpAQfTLLQSRLPFTLATNQVEISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGGRL--------------- 217
Cdd:cd19077 144 RGIGLSEVS-AE-TIRRAHAVHPIAAVEVEYSLFSREIEENGVLETCAELGIPIIAYSPLGRGLLtgriksladipegdf 221
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695764355 218 ------FNDESF---QPLRDELAQVAKELNAeSIEQVVYAWILRLpSQP--LPIIGSGKIERVRSAVVAEKMNMSRQQ 284
Cdd:cd19077 222 rrhldrFNGENFeknLKLVDALQELAEKKGC-TPAQLALAWILAQ-SGPkiIPIPGSTTLERVEENLKAANVELTDEE 297
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
27-273 |
2.77e-11 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 62.95 E-value: 2.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlrgRMEIVskcgIATKAraentiGHYITD---- 102
Cdd:cd19163 28 GPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGIP----RDSYY----LATKV------GRYGLDpdkm 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 103 ----RDHIVLSAEQSLRNLATDHLDLLLIHRPD--PLMD--ADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPF 174
Cdd:cd19163 94 fdfsAERITKSVEESLKRLGLDYIDIIQVHDIEfaPSLDqiLNETLPALQKLKEEGKVRFIGITGYPLDVLKEVLERSPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 175 TLatnQVEISPVHQPLL---LDGTLDQLQQLRIRPMAWSCLGGGRLFNDESFQ--PLRDELAQVAKELNA------ESIE 243
Cdd:cd19163 174 KI---DTVLSYCHYTLNdtsLLELLPFFKEKGVGVINASPLSMGLLTERGPPDwhPASPEIKEACAKAAAycksrgVDIS 250
|
250 260 270
....*....|....*....|....*....|
gi 695764355 244 QVVYAWILRLPSQPLPIIGSGKIERVRSAV 273
Cdd:cd19163 251 KLALQFALSNPDIATTLVGTASPENLRKNL 280
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
27-224 |
3.88e-11 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 62.16 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHL---RGRMEIVSKCgiatkaraentighYITDR 103
Cdd:cd19121 20 WQAKAGEVKAAVAHALKIGYRHIDGALCYQN---EDEVGEGIKEAIAGgvkREDLFVTTKL--------------WSTYH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 104 DHIVLSAEQSLRNLATDHLDLLLIHRP--------DPLM------------DADEV-----AEAFLAlhhSGKVRHFGVS 158
Cdd:cd19121 83 RRVELCLDRSLKSLGLDYVDLYLVHWPvllnpngnHDLFptlpdgsrdldwDWNHVdtwkqMEKVLK---TGKTKAIGVS 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695764355 159 NFTPAQFTLLQSRLPFTLATNQVEISP-VHQPLLLDGTLDQlqqlRIRPMAWSCLG--GGRLFNDESFQ 224
Cdd:cd19121 160 NYSIPYLEELLKHATVVPAVNQVENHPyLPQQELVDFCKEK----GILIEAYSPLGstGSPLISDEPVV 224
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
27-249 |
7.14e-11 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 61.75 E-value: 7.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALKQAPHLRGRMEIVSKCGIATKARAENTIghyitdrdhi 106
Cdd:cd19117 22 WQSKPNEVAKAVEAALKAGYRHIDTAAIYGN---EEEVGQGIKDSGVPREEIFITTKLWCTWHRRVEEAL---------- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 107 vlsaEQSLRNLATDHLDLLLIHRPDPLMDADEVA---------------------EAFLALHHSGKVRHFGVSNF-TPAQ 164
Cdd:cd19117 89 ----DQSLKKLGLDYVDLYLMHWPVPLDPDGNDFlfkkddgtkdhepdwdfiktwELMQKLPATGKVKAIGVSNFsIKNL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 165 FTLLQSRL-PFTLATNQVEISPVH-QPLLldgtLDQLQQLRIRPMAWSCLG--GGRLFNDESfqplrdeLAQVAKELNAE 240
Cdd:cd19117 165 EKLLASPSaKIVPAVNQIELHPLLpQPKL----VDFCKSKGIHATAYSPLGstNAPLLKEPV-------IIKIAKKHGKT 233
|
....*....
gi 695764355 241 SiEQVVYAW 249
Cdd:cd19117 234 P-AQVIISW 241
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
49-284 |
1.23e-10 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 61.29 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 49 VDHADIYGDYQCEAAFGEALKQaphlRG-RMEIVskcgIATKAraenTIGHYITDRDHI------------VLSAEQSLR 115
Cdd:cd19146 52 IDTANNYQGEESERWVGEWMAS----RGnRDEMV----LATKY----TTGYRRGGPIKIksnyqgnhakslRLSVEASLK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 116 NLATDHLDLLLIHRPDPLMDADEVAEAflaLHH---SGKVRHFGVSNfTPA----------------QFTLLQSRLPFTL 176
Cdd:cd19146 120 KLQTSYIDILYVHWWDYTTSIPELMQS---LNHlvaAGKVLYLGVSD-TPAwvvskanayarahgltQFVVYQGHWSAAF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 177 ATNQVEISPVHQPllldgtldqlQQLRIRPmaWSCLGGGRLFNDESFQP---------LRDE--------LAQVAKELNA 239
Cdd:cd19146 196 RDFERDILPMCEA----------EGMALAP--WGVLGQGQFRTEEEFKRrgrsgrkggPQTEkerkvsekLEKVAEEKGT 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 695764355 240 eSIEQVVYAWILRLPSQPLPIIGSGKIERVRSAVVAEKMNMSRQQ 284
Cdd:cd19146 264 -AITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEE 307
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
27-251 |
1.30e-10 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 60.89 E-value: 1.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYgdyQCEAAFGEALKQ--APHLRGRMEIVskcgIATKAraentigHYITDRD 104
Cdd:cd19154 20 WQSKGAEGITAVRTALKAGYRLIDTAFLY---QNEEAIGEALAEllEEGVVKREDLF----ITTKL-------WTHEHAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 105 HIVLSA-EQSLRNLATDHLDLLLIHRPDPLMDAD-------------------EVAEAFLALHHSGKVRHFGVSNFTPAQ 164
Cdd:cd19154 86 EDVEEAlRESLKKLQLEYVDLYLIHAPAAFKDDEgesgtmengmsihdavdveDVWRGMEKVYDEGLTKAIGVSNFNNDQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 165 FTLLQSRLPFTLATNQVEISP-VHQPLLldgtLDQLQQLRIRPMAWSCLGG-GRLFNDES--FQPLRDELA-QVAKELNA 239
Cdd:cd19154 166 IQRILDNARVKPHNNQVECHLyFPQKEL----VEFCKKHNISVTSYATLGSpGRANFTKStgVSPAPNLLQdPIVKAIAE 241
|
250
....*....|....*
gi 695764355 240 ---ESIEQVVYAWIL 251
Cdd:cd19154 242 khgKTPAQVLLRYLL 256
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
42-259 |
1.26e-09 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 58.06 E-value: 1.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDyqcEAAFGEALkqaphlrgRMEIvsKCGIATkaRAEntigHYIT--------DRDHIVLSAEQS 113
Cdd:cd19116 35 IEAGYRHIDTAYLYGN---EAEVGEAI--------REKI--AEGVVK--RED----LFITtklwnsyhEREQVEPALRES 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 114 LRNLATDHLDLLLIHRP------------DPLMDAD----EVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLA 177
Cdd:cd19116 96 LKRLGLDYVDLYLIHWPvafkenndsesnGDGSLSDidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNCNIKPA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 178 TNQVEISPvhqpllldgTLDQL------QQLRIRPMAWSCLGggrlFNDESFQP-----LRDE-LAQVAKELNaESIEQV 245
Cdd:cd19116 176 VNQIEVHP---------TLTQEklvaycQSNGIVVMAYSPFG----RLVPRGQTnppprLDDPtLVAIAKKYG-KTTAQI 241
|
250
....*....|....
gi 695764355 246 VYAWILRLPSQPLP 259
Cdd:cd19116 242 VLRYLIDRGVVPIP 255
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
42-161 |
2.73e-09 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 56.90 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDyqCEAAFGEALK--QAPHLRGRMEIVSKCGiatkaraentigHYITD-----RDHIVLSAEQSL 114
Cdd:cd19164 44 LELGIRAFDTSPYYGP--SEIILGRALKalRDEFPRDTYFIITKVG------------RYGPDdfdysPEWIRASVERSL 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 695764355 115 RNLATDHLDLLLIHrpD-PLMDADEVAEAFLALHH---SGKVRHFGVSNFT 161
Cdd:cd19164 110 RRLHTDYLDLVYLH--DvEFVADEEVLEALKELFKlkdEGKIRNVGISGYP 158
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
31-203 |
1.02e-08 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 55.23 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 31 VNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGiatKARAENtighYITDRDHIVLSA 110
Cdd:cd19153 32 QDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSYTVATKVG---RYRDSE----FDYSAERVRASV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 111 EQSLRNLATDHLDLLLIHR---PDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPftLATNQVEISPVH 187
Cdd:cd19153 105 ATSLERLHTTYLDVVYLHDiefVDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRATRRCS--PGSLDAVLSYCH 182
|
170
....*....|....*.
gi 695764355 188 QPLLLDGTLDQLQQLR 203
Cdd:cd19153 183 LTLQDARLESDAPGLV 198
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
51-259 |
2.05e-08 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 54.17 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 51 HADIYGDYQCEAAFGEA----LKQAPHLRgRMEIVskcgIATKaraentIGHYITDRDHIVLSAEQSLRNLATDHLDLLL 126
Cdd:cd19122 40 HLDCAWFYLNEDEVGDAvrdfLKENPSVK-REDLF----ICTK------VWNHLHEPEDVKWSIDNSLKNLKLDYIDLFL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 127 IHRP---------DPLMDAD-------EVAE-------AFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVEI 183
Cdd:cd19122 109 VHWPiaaekndqrSPKLGPDgkyvilkDLTEnpeptwrAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 184 SPVhqpLLLDGTLDQLQQLRIRPMAWSCLGG-------GRLFNDesfQPLRDELAqvakELNAESIEQVVYAWILR---- 252
Cdd:cd19122 189 HPF---LPNEELVDYCFSNDILPEAYSPLGSqnqvpstGERVSE---NPTLNEVA----EKGGYSLAQVLIAWGLRrgyv 258
|
....*...
gi 695764355 253 -LPSQPLP 259
Cdd:cd19122 259 vLPKSSTP 266
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
35-173 |
4.52e-08 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 53.24 E-value: 4.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 35 VSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGiatkaraeNTIGHYITDRDHIVLSAEQSL 114
Cdd:PLN02587 34 IASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGIPREKYVVSTKCG--------RYGEGFDFSAERVTKSVDESL 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764355 115 RNLATDHLDLLLIHRPDpLMDADEVAE----AFLALHHSGKVRHFGVSNFTPAQFTLLQSRLP 173
Cdd:PLN02587 106 ARLQLDYVDILHCHDIE-FGSLDQIVNetipALQKLKESGKVRFIGITGLPLAIFTYVLDRVP 167
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
45-269 |
6.46e-08 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 52.83 E-value: 6.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 45 GVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKcgIATKARAENTIGhyiTDRDHIVLSAEQSLRNLATDHLDL 124
Cdd:cd19141 43 GINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTK--IFWGGKAETERG---LSRKHIIEGLKASLERLQLEYVDI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 125 LLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPA----------QFTLL-----QSRLPFTlatnQVEISPVHQP 189
Cdd:cd19141 118 VFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMeimeaysvarQFNLIppiveQAEYHLF----QREKVEMQLP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 190 LLldgtldqLQQLRIRPMAWSCLGGGRL---FND----------ESFQPLRD---------------ELAQVAKELNAeS 241
Cdd:cd19141 194 EL-------FHKIGVGAMTWSPLACGILsgkYDDgvpeysraslKGYQWLKEkilseegrrqqaklkELQIIADRLGC-T 265
|
250 260
....*....|....*....|....*...
gi 695764355 242 IEQVVYAWILRLPSQPLPIIGSGKIERV 269
Cdd:cd19141 266 LPQLAIAWCLKNEGVSSVLLGASSTEQL 293
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
45-162 |
2.02e-07 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 51.70 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 45 GVTTVDHADIYGDYQCEAAFGEALKQAPHLRgrmeivSKCGIATKARAENTIGHYITDRDHIVLSAEQSLRNLATDHLDL 124
Cdd:cd19142 44 GINYFDTSDAFTSGQAETELGRILKKKGWKR------SSYIVSTKIYWSYGSEERGLSRKHIIESVRASLRRLQLDYIDI 117
|
90 100 110
....*....|....*....|....*....|....*...
gi 695764355 125 LLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTP 162
Cdd:cd19142 118 VIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSP 155
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
38-239 |
5.39e-07 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 50.30 E-value: 5.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlRGRMEIVSKCG---IATKARAENTIGHYITDRDHIVL------ 108
Cdd:cd19152 26 LVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELG--REDYVISTKVGrllVPLQEVEPTFEPGFWNPLPFDAVfdysyd 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 109 ----SAEQSLRNLATDHLDLLLIHRPDPLMDADE--------VAEAFLALHH---SGKVRHFGV-SNF-TPAQFTLLQSR 171
Cdd:cd19152 104 gilrSIEDSLQRLGLSRIDLLSIHDPDEDLAGAEsdehfaqaIKGAFRALEElreEGVIKAIGLgVNDwEVILRILEEAD 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695764355 172 LPFTLATNQVeiSPVHQPLLLDgTLDQLQQLRIR-----PMAWSCLGGGRLFNDESFQPLRDELAQVAKELNA 239
Cdd:cd19152 184 LDWVMLAGRY--TLLDHSAARE-LLPECEKRGVKvvnagPFNSGFLAGGDNFDYYEYGPAPPELIARRDRIEA 253
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
51-232 |
8.68e-07 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 49.42 E-value: 8.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 51 HADIYGDYQCEAAFGEALKQA--PHLRGRMEIVskcgIATKAraentighYITDRDHIVLSAEQSLRNLATDHLDLLLIH 128
Cdd:cd19119 43 HIDTAYAYETEDFVGEAIKRAidDGSIKREELF----ITTKV--------WPTFYDEVERSLDESLKALGLDYVDLLLVH 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 129 RPDPLM-DADEVAEAFLALHHSGKVRH------------------------FGVSNFTPAQFTLLQSRLPFTLATNQVEI 183
Cdd:cd19119 111 WPVCFEkDSDDSGKPFTPVNDDGKTRYaasgdhittykqlekiyldgrakaIGVSNYSIVYLERLIKECKVVPAVNQVEL 190
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 695764355 184 SPvHQPLLldGTLDQLQQLRIRPMAWSCLGGGR---LFNdesfqPLRDELAQ 232
Cdd:cd19119 191 HP-HLPQM--DLRDFCFKHGILVTAYSPLGSHGapnLKN-----PLVKKIAE 234
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
43-275 |
9.36e-07 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 49.31 E-value: 9.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 43 DLGVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGIATKARAENTIghyitDRDHIVLSAEQSLRNLATDHL 122
Cdd:cd19158 42 DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGL-----SRKHIIEGLKASLERLQLEYV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 123 DLLLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQS-RLPFTLATNQVEISPVH--QPLLLDGTLDQL 199
Cdd:cd19158 117 DVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSvARQFNLIPPICEQAEYHmfQREKVEVQLPEL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 200 -QQLRIRPMAWSCLGGGRLFND-------------ESFQPLRD---------------ELAQVAKELNAeSIEQVVYAWI 250
Cdd:cd19158 197 fHKIGVGAMTWSPLACGIVSGKydsgippysraslKGYQWLKDkilseegrrqqaklkELQAIAERLGC-TLPQLAIAWC 275
|
250 260
....*....|....*....|....*
gi 695764355 251 LRLPSQPLPIIGSGKIERVRSAVVA 275
Cdd:cd19158 276 LRNEGVSSVLLGASNAEQLMENIGA 300
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
45-269 |
1.06e-06 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 49.27 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 45 GVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGIATKARAENTIghyitDRDHIVLSAEQSLRNLATDHLDL 124
Cdd:cd19159 44 GVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGL-----SRKHIIEGLKGSLQRLQLEYVDV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 125 LLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQFTLLQS-RLPFTLATNQVEISPVH--QPLLLDGTLDQL-Q 200
Cdd:cd19159 119 VFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSvARQFNMIPPVCEQAEYHlfQREKVEVQLPELyH 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 201 QLRIRPMAWSCLGGGRLFND-------------ESFQPLRD---------------ELAQVAKELNAeSIEQVVYAWILR 252
Cdd:cd19159 199 KIGVGAMTWSPLACGIISGKygngvpessraslKCYQWLKErivseegrkqqnklkDLSPIAERLGC-TLPQLAVAWCLR 277
|
250
....*....|....*..
gi 695764355 253 LPSQPLPIIGSGKIERV 269
Cdd:cd19159 278 NEGVSSVLLGSSTPEQL 294
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
42-249 |
1.52e-06 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 48.92 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYGDyqcEAAFGEALKQA-----PHLRGRMEIVSKCGiATKARAENTIGhyitdrdhivlSAEQSLRN 116
Cdd:cd19106 30 LDAGYRHIDCAAVYGN---EQEVGEALKEKvgpgkAVPREDLFVTSKLW-NTKHHPEDVEP-----------ALRKTLKD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 117 LATDHLDLLLIHRP--------------DPLMDADEVA-----EAFLALHHSGKVRHFGVSNFTPAQFTLLQSRLPFTLA 177
Cdd:cd19106 95 LQLDYLDLYLIHWPyafergdnpfpknpDGTIRYDSTHyketwKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPA 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695764355 178 TNQVEISP--VHQPLlldgtLDQLQQLRIRPMAWSCLGG-GRLFNDESFQPLRDE--LAQVAKELNaESIEQVVYAW 249
Cdd:cd19106 175 VLQVECHPylAQNEL-----IAHCKARGLVVTAYSPLGSpDRPWAKPDEPVLLEEpkVKALAKKYN-KSPAQILLRW 245
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
111-246 |
8.28e-06 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 46.33 E-value: 8.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 111 EQSLRNLATDHLDLLLIHRPDPLMDADEVA-------------------EAFLALHHSGKVRHFGVSNFTPAQFTLLQSR 171
Cdd:cd19109 89 ERTLKVLQLDYVDLYIIEMPMAFKPGDEIYprdengkwlyhktnlcatwEALEACKDAGLVKSIGVSNFNRRQLELILNK 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 172 --LPFTLATNQVEISP-VHQPLLLDGTldqlQQLRIRPMAWSCLGGGR--LFNDESFQP-LRDE-LAQVAKELNaESIEQ 244
Cdd:cd19109 169 pgLKHKPVSNQVECHPyFTQPKLLEFC----QQHDIVIVAYSPLGTCRdpIWVNVSSPPlLEDPlLNSIGKKYN-KTAAQ 243
|
..
gi 695764355 245 VV 246
Cdd:cd19109 244 VV 245
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
38-158 |
8.77e-06 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 46.20 E-value: 8.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 38 IEQHLDLGVTTVDHADIYGDYQCEAAFGEALkqAPHLRGRMEIVSKCGIATKARAENTIGHYITD----RDHIVLSAEQS 113
Cdd:cd19162 25 LDAAWDAGIRYFDTAPLYGLGLSERRLGAAL--ARHPRAEYVVSTKVGRLLEPGAAGRPAGADRRfdfsADGIRRSIEAS 102
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 695764355 114 LRNLATDHLDLLLIHRPDPLMDA--DEVAEAFLALHHSGKVRHFGVS 158
Cdd:cd19162 103 LERLGLDRLDLVFLHDPDRHLLQalTDAFPALEELRAEGVVGAIGVG 149
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
24-229 |
5.17e-05 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 44.18 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 24 LMDWNMSVNERVSFIEQHLDLGVTTVDHADIY-GDYQCEAAFGEALKQAPHLRGRMEIVSK--CGIATKARAENtighyi 100
Cdd:cd19110 9 LGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYhNESEVGAGIREKIKEGVVRREDLFIVSKlwCTCHKKSLVKT------ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 101 tdrdhivlSAEQSLRNLATDHLDLLLIHRP------DPLMDADEVA-------------EAFLALHHSGKVRHFGVSNFT 161
Cdd:cd19110 83 --------ACTRSLKALKLNYLDLYLIHWPmgfkpgEPDLPLDRSGmvipsdtdfldtwEAMEDLVIEGLVKNIGVSNFN 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764355 162 PAQFTLLQSR--LPFTLATNQVEISP-VHQPLLLDgtLDQLQQLRI---RPMAWSClGGGRLFNDESFQPLRDE 229
Cdd:cd19110 155 HEQLERLLNKpgLRVKPVTNQIECHPyLTQKKLIS--FCQSRNVSVtayRPLGGSC-EGVDLIDDPVIQRIAKK 225
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
29-162 |
5.48e-05 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 44.07 E-value: 5.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 29 MSVNERVSFIEQHLDL------GVTTVDHADIYG-----DYQ--CEAAFGEALKQAPHlRGRMEIVSKCGIATKARAENT 95
Cdd:PRK10625 21 MTFGEQNSEADAHAQLdyavaqGINLIDVAEMYPvpprpETQglTETYIGNWLAKRGS-REKLIIASKVSGPSRNNDKGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 96 IGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPD-----------------PLMDADEVAEAFLALHHSGKVRHFGVS 158
Cdd:PRK10625 100 RPNQALDRKNIREALHDSLKRLQTDYLDLYQVHWPQrptncfgklgyswtdsaPAVSLLETLDALAEQQRAGKIRYIGVS 179
|
....
gi 695764355 159 NFTP 162
Cdd:PRK10625 180 NETA 183
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
45-164 |
5.77e-05 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 43.82 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 45 GVTTVDHADIYGDYQCEAAFGEALKQAPHLRGRMEIVSKCGIATKARAENTIghyitDRDHIVLSAEQSLRNLATDHLDL 124
Cdd:cd19160 46 GVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVVTTKIYWGGQAETERGL-----SRKHIIEGLRGSLDRLQLEYVDI 120
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 695764355 125 LLIHRPDPLMDADEVAEAFLALHHSGKVRHFGVSNFTPAQ 164
Cdd:cd19160 121 VFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAME 160
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
42-185 |
6.65e-05 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 43.56 E-value: 6.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 42 LDLGVTTVDHADIYgdyQCEAAFGEALKQAPH----LRGRMEIVSKCgiatkaraentighYITDRD-HIVLSA-EQSLR 115
Cdd:cd19107 27 IDAGYRHIDCAYVY---QNENEVGEAIQEKIKeqvvKREDLFIVSKL--------------WCTFHEkGLVKGAcQKTLS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 116 NLATDHLDLLLIHRPD---------PLMDADEVA----------EAFLALHHSGKVRHFGVSNFTPAQFTLLQSR--LPF 174
Cdd:cd19107 90 DLKLDYLDLYLIHWPTgfkpgkelfPLDESGNVIpsdttfldtwEAMEELVDEGLVKAIGVSNFNHLQIERILNKpgLKY 169
|
170
....*....|.
gi 695764355 175 TLATNQVEISP 185
Cdd:cd19107 170 KPAVNQIECHP 180
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
27-259 |
2.32e-04 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 42.13 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 27 WNMSVNERVSFIEQHLDLGVTTVDHADIYGDyqcEAAFGEALK---QAPHL-RGRMEIVSKCGiATKARAENtIGHYITd 102
Cdd:cd19155 20 WQSSPEEIETAVDTALEAGYRHIDTAYVYRN---EAAIGNVLKkwiDSGKVkREELFIVTKLP-PGGNRREK-VEKFLL- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 103 rdhivlsaeQSLRNLATDHLDLLLIHRP---------------------DPLMDADEVAEAFLALHHSGKVRHFGVSNFT 161
Cdd:cd19155 94 ---------KSLEKLQLDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 162 PAQFTLLQSRLPFTLATNQVEIspvHQPLLLDGTLDQLQQLRIRPMAWSCLG--GGRLFND-------ESFQPLRD-ELA 231
Cdd:cd19155 165 REQMARILKNARIKPANLQVEL---HVYLQQKDLVDFCSTHSITVTAYAPLGspGAAHFSPgtgspsgSSPDLLQDpVVK 241
|
250 260
....*....|....*....|....*...
gi 695764355 232 QVAKELNaESIEQVVYAWILRLPSQPLP 259
Cdd:cd19155 242 AIAERHG-KSPAQVLLRWLMQRGVVVIP 268
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
111-193 |
2.42e-04 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 41.83 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 111 EQSLRNLATDHLDLLLIHRPDPLMDADEVA-------------------EAFLALHHSGKVRHFGVSNFTPAQFTLLQSR 171
Cdd:cd19108 95 EKSLKKLQLDYVDLYLIHFPVALKPGEELFpkdengklifdtvdlcatwEAMEKCKDAGLAKSIGVSNFNRRQLEMILNK 174
|
90 100
....*....|....*....|....*
gi 695764355 172 --LPFTLATNQVEISP-VHQPLLLD 193
Cdd:cd19108 175 pgLKYKPVCNQVECHPyLNQSKLLD 199
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
28-153 |
5.68e-04 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 40.77 E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 28 NMSVNERVSFIEQHLDLGVTTVDHADIYGDYQCEAAFGEALKQAPhlrgRMEIV--SKCG-IATKARAENT--------- 95
Cdd:cd19161 16 AVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKP----RDEFVlsTKVGrLLKPAREGSVpdpngfvdp 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764355 96 ---IGHYITDRDHIVLSAEQSLRNLATDHLDLLLIHRPDPLMDADEVAEAFLALHHSGKVR 153
Cdd:cd19161 92 lpfEIVYDYSYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRKERHHFAQLMSGGFK 152
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
43-276 |
1.44e-03 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 39.64 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 43 DLGVTTVDHADIYGdyQCEAAFGEALKQAPHLRGRMEIVSKCGIATKARAE-NTIGHYITDRDHIVLSAE-QSLRNLATD 120
Cdd:cd19098 46 AAGVRYFDAARSYG--RAEEFLGSWLRSRNIAPDAVFVGSKWGYTYTADWQvDAAVHEVKDHSLARLLKQwEETRSLLGK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 121 HLDLLLIHRP---DPLMDADEVAEAFLALHHSGkvRHFGVSNFTPAQFTLLqsRLPFTLATNQVEISPVHQP---LLLDG 194
Cdd:cd19098 124 HLDLYQIHSAtleSGVLEDADVLAALAELKAEG--VKIGLSLSGPQQAETL--RRALEIEIDGARLFDSVQAtwnLLEQS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764355 195 TLDQLQQLR---IRPMAWSCLGGGRLF---NDESFQPLRDELAQVAKELNAeSIEQVVYAWILRLPSQPLPIIGSGKIER 268
Cdd:cd19098 200 AGEALEEAHeagMGVIVKEALANGRLTdrnPSPELAPLMAVLKAVADRLGV-TPDALALAAVLAQPFVDVVLSGAATPEQ 278
|
....*...
gi 695764355 269 VRSAVVAE 276
Cdd:cd19098 279 LRSNLRAL 286
|
|
| |
