|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
1-457 |
0e+00 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 714.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 1 MQKYFIEARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGR 80
Cdd:PRK01766 4 TQKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 81 RDRIAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPG 160
Cdd:PRK01766 84 RERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 161 MVMGFIGLLVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEGFSGPDFSVLKRLVQ 240
Cdd:PRK01766 164 MVIGFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 241 LGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVG 320
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 321 VGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGL 400
Cdd:PRK01766 324 VGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGL 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 695764336 401 PSGYLLALTDtlvpRMGPAGFWCGFIIGLTSAAVMMMLRMRFLQRQPSSVILQRAAR 457
Cdd:PRK01766 404 PLGYILALTD----PMGPFGFWIGLIIGLTAAAILLLLRLRKLQRQPSAIILQRAAR 456
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
7-445 |
1.53e-179 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 508.96 E-value: 1.53e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 7 EARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAH 86
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 87 QIRQGFWLAGFVSLLVMVVLWNAGYIISSMhNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLLWLAPPILPLM-GQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 167 GLLVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEGFSGPDFSVLKRLVQLGLPIA 246
Cdd:cd13131 160 ALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 247 LALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMA 326
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 327 VITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLL 406
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLL 399
|
410 420 430
....*....|....*....|....*....|....*....
gi 695764336 407 ALTDtlvpRMGPAGFWCGFIIGLTSAAVMMMLRMRFLQR 445
Cdd:cd13131 400 AFTT----GLGAFGVWIGLIIGLALAAILLLWRFRRLQR 434
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
17-362 |
5.08e-102 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 308.02 E-value: 5.08e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 17 PVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIRQGFWLAG 96
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 97 FVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNY 176
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 177 IFIYGHFGMpeLGGIGCGVATASVYWVMFFCMISWVRRARSMRdiRSDEGFSGPDFSVLKRLVQLGLPIALALFFEVTLF 256
Cdd:TIGR00797 161 ILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAKKIG--LKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 257 AVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVITAIFTILM 336
Cdd:TIGR00797 237 ALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330 340
....*....|....*....|....*.
gi 695764336 337 RKQIALLYNDNPEVVLLASQLMLLAA 362
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
9-439 |
2.63e-95 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 293.59 E-value: 2.63e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVV-LWNAGYIISSMhNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIG 167
Cdd:COG0534 88 GQALLLALLLGLLLTLLgLLFAPPLLRLL-GADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 168 LLVNIPVNYIFIYGhfgmPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEgfSGPDFSVLKRLVQLGLPIAL 247
Cdd:COG0534 167 NVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRD--LRPDRKILKRILRIGLPAGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 248 ALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAV 327
Cdd:COG0534 241 QQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 328 ITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLA 407
Cdd:COG0534 321 LLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLA 400
|
410 420 430
....*....|....*....|....*....|..
gi 695764336 408 LTDtlvprMGPAGFWCGFIIGLTSAAVMMMLR 439
Cdd:COG0534 401 FLG-----LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-441 |
1.93e-71 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 232.42 E-value: 1.93e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13133 85 WQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 169 LVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEGFsGPDFSVLKRLVQLGLPIALA 248
Cdd:cd13133 165 VVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAW-RFDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 249 LFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVI 328
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 329 TAIFTILMRKQIALLYNDNP---EVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYL 405
Cdd:cd13133 324 LGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYL 403
|
410 420 430
....*....|....*....|....*....|....*.
gi 695764336 406 LAltdtlVPRMGPAGFWCGFIIGLTSAAVMMMLRMR 441
Cdd:cd13133 404 LV-----VLGAGLAGAWTVETVYVIVLALIFLLRFR 434
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
7-446 |
5.02e-70 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 229.63 E-value: 5.02e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 7 EARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAH 86
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 87 QIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNiDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:PRK00187 88 LAQAGLWLAWLLALVAALLLWNLKPLLLLFGQ-APQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 167 GLLVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEGFSGPDFSVLKRLVQLGLPIA 246
Cdd:PRK00187 167 GAVANLLLNYALIEGWFGLPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAALRELWRLGLPIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 247 LALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMA 326
Cdd:PRK00187 247 GTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 327 VITAIFTILMRKQIALLYND-----NPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLP 401
Cdd:PRK00187 327 LLFAGLFWLLPEAIIGLFLDrndpaFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAP 406
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 695764336 402 SGYLLALTDTLvprmGPAGFWCGFIIGLTSAAVMMML----RMRFLQRQ 446
Cdd:PRK00187 407 LAWLLAFTLGW----GAVGVWWGLALGLACAAVALTLafewKTARLLRK 451
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
7-438 |
2.02e-65 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 216.67 E-value: 2.02e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 7 EARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIwlpAILFGHGLLL----ALTPVIAQLNGSGRRD 82
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSF---ANVTGFSILLglasALDTLCGQAFGAKNYK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 83 RIAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSMHnIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMV 162
Cdd:cd13132 78 LVGVYLQRALVILLLCCVPISLLWLNTEPILLLLG-QDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 163 MGFIGLLVNIPVNYIFIYGHfgmpELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRsdEGFSGPDFSVLKRLVQLG 242
Cdd:cd13132 157 ISLVALLLNILLNYLLVFVL----GLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATW--GGFSREAFRGWGPFLKLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 243 LPIALALFFEVTLFAVVALLVSPL-GIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGV 321
Cdd:cd13132 231 IPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALIL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 322 GVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLP 401
Cdd:cd13132 311 SLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLP 390
|
410 420 430
....*....|....*....|....*....|....*..
gi 695764336 402 SGYLLAltdtLVPRMGPAGFWCGFIIGLTSAAVMMML 438
Cdd:cd13132 391 VGLLLA----FVLGLGLKGLWIGLIAGLILQAVILLL 423
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-441 |
6.03e-61 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 204.67 E-value: 6.03e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 169 LVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMrdIRSDEGFSGPDFSVLKRLVQLGLPIALA 248
Cdd:cd13137 161 VLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLP--IKISFKGFRLDRKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 249 LFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVI 328
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 329 TAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLAl 408
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLG- 397
|
410 420 430
....*....|....*....|....*....|...
gi 695764336 409 tdtLVPRMGPAGFWCGFIIGLTSAAVMMMLRMR 441
Cdd:cd13137 398 ---FVLGLGLTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-441 |
2.42e-49 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 174.23 E-value: 2.42e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGapgyLFFQVARNQCEGL----AKTKPGMVMG 164
Cdd:cd13134 83 GVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGS----LFLQALSLTLSAIlrshGRTKIPMYVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 165 FIGLLVNIPVNYIFIYGHFGMPELGGIGCGVATA-------SVYWVMFFCMISWVRRARSMRDIrsdegfsgpDFSVLKR 237
Cdd:cd13134 159 LIMNILNIVGNYLLIFGWFGLPKLGVAGVAISTVisravglVLLFILLFRKLKIRFRLKDLRPF---------PKKLLKK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 238 LVQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSART 317
Cdd:cd13134 230 ILKIGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLK 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 318 GVGVGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWV 397
Cdd:cd13134 310 SLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWG 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 695764336 398 LGLPSGYLLAltdtLVPRMGPAGFWCGFIIGLTSAAVMMMLRMR 441
Cdd:cd13134 390 ISVPLAYLLG----IVLGLGLLGVWIAFAADEWVRGIIMLWRWR 429
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
15-439 |
3.77e-48 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 170.58 E-value: 3.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 15 AIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIRQGFWL 94
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 95 AGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPV 174
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 175 NYIFIYGhFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDegFSGPDFSVLKRLVQLGLPIALALFFEVT 254
Cdd:cd12082 161 DPLLIFG-LGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLS--LLKPDLELLRRLLRIGLPSAIQNSLLSL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 255 LFAVVALLVSPL-GIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVITAIFT 333
Cdd:cd12082 238 GLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 334 ILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLALTDtlv 413
Cdd:cd12082 318 LLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG--- 394
|
410 420
....*....|....*....|....*.
gi 695764336 414 prMGPAGFWCGFIIGLTSAAVMMMLR 439
Cdd:cd12082 395 --LGLYGIWLALVISLILAALVLLLF 418
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-435 |
1.46e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 144.91 E-value: 1.46e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATD-MAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQ 87
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAaLAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 88 IRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAP---GYLFFQVARNqceGLAKTKPGMVMG 164
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPfifGYNAYSAILR---GLGDSKTPLYFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 165 FIGLLVNIPVNYIFIYGhFGMpelGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDegFSGPDFSVLKRLVQLGLP 244
Cdd:cd13138 160 IIACVLNIILDLLFIAV-FHM---GVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLK--DFRFDKEILKEILKIGLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 245 IALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVC 324
Cdd:cd13138 234 SALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 325 MAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGY 404
Cdd:cd13138 314 IGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAY 393
|
410 420 430
....*....|....*....|....*....|.
gi 695764336 405 LLALTdtlvPRMGPAGFWCGFIIGLTSAAVM 435
Cdd:cd13138 394 LLSRL----TGLGLFGIWLAMPISNILSAII 420
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-438 |
4.28e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 143.87 E-value: 4.28e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 8 ARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQ 87
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 88 IRQGFWLAGFVSLLVMVV-LWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13142 90 AGQTFSFVIILSLILAVLgYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 167 GLLVNIPVNYIFIYGHFGMPELGGIGCGVAT------ASVY--WVMFFCMISWVRRARSMRdirsdegfsgPDFSVLKRL 238
Cdd:cd13142 170 SVLLNVILDPLLIFGIGPFPGLGVAGAALATvisrgiAAVIglYLLFKGRVGLKISLRDLK----------PDWEWLKKI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 239 VQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTG 318
Cdd:cd13142 240 FRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 319 VGVGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVL 398
Cdd:cd13142 320 ALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVI 399
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 695764336 399 GLPSGYLLALTDTlvprMGPAGFWCGFIIGLTSAAVMMML 438
Cdd:cd13142 400 RIPLAYLLAYVLG----LGVTGIWIAMAISNIVAALIALA 435
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
17-177 |
1.94e-33 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 123.44 E-value: 1.94e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 17 PVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIRQGFWLAG 96
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 97 FVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNY 176
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 695764336 177 I 177
Cdd:pfam01554 161 L 161
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
9-441 |
1.50e-32 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 128.06 E-value: 1.50e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGY-SATDMAAVAIGTSI-----WLPAILfghglLLALTPVIAQLNGSGRRD 82
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLgSAAYLGAVALGTTIfntlfWLFGFL-----RMGTTGLVAQALGAGDRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 83 RIAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMV 162
Cdd:cd13136 78 EAIALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 163 MGFIGLLVNIPVNYIFIYGhFGMpelgGIGcGVATASVY--WVMFFCMISWVRRarSMRDIRSDEGFSGPDFSVLKRLVQ 240
Cdd:cd13136 158 LQIVGNVVNIVLDPLFVFG-LGW----GVA-GAALATVIaqYLGALLGLWLLRR--RVRLLGKSLSRRLPSKAALKRLFK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 241 LGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVG 320
Cdd:cd13136 230 LNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 321 VGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRsiffitFTAYWVLGL 400
Cdd:cd13136 310 WGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTR------YLRNSMLVS 383
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 695764336 401 PSGYLLALTdTLVPRMGPAGFWCGFIIGLTSAAVMMMLRMR 441
Cdd:cd13136 384 LAVFLPLLF-LLVPLWGNHGLWLALILFMLLRGLTLALRLP 423
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
244-405 |
2.28e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 112.66 E-value: 2.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 244 PIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGV 323
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 324 CMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYwVLGLPSG 403
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
..
gi 695764336 404 YL 405
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-431 |
8.48e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 108.77 E-value: 8.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 8 ARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAV-AIGTSIWLpailfghGLLLALTPVI------AQLNGSGR 80
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVgTAGFFVWL-------AYALALLSKIgaqvkvSQSIGAKD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 81 RDRIAHQIRQGFWLAGFVSLLVMVVLWNAG-YIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKP 159
Cdd:cd13140 77 EKEARKYARNALQLNLLLGILYGLLLLLFAkPLIGFFNLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 160 GMVMGFIGLLVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMIswvrrARSMRDIRSDEG---FSGPDFSVLK 236
Cdd:cd13140 157 PFIINAIGLVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFL-----YALKKKKGLFLKiriLKRPDRKYIK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 237 RLVQLGLPIAL--ALFfevTLFAVV-ALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQV 313
Cdd:cd13140 232 EILKLGLPVALqsILF---ALISMIlARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRK 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 314 SARTGVGVGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTR--SIFFIT 391
Cdd:cd13140 309 GYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKppAIISIV 388
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 695764336 392 FTAywvLGLPSGYLLAltdtlVPRMGPAGFWcgFIIGLTS 431
Cdd:cd13140 389 FNG---LRIPLALLLS-----PTGLGLNGIW--WAISISS 418
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-441 |
2.56e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 107.38 E-value: 2.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 11 LLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIRQ 90
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 91 GFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLR--ALLWGAPGYLFFQVARNQceGLAKTKPGMVMGFIGL 168
Cdd:cd13135 83 SIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRifSIYLLLLGILFTFSSILQ--GIGETKPIMYGGIIKN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 169 LVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEGFSGPDFSVLKRLVQLGLPIALA 248
Cdd:cd13135 161 LLNVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTIKLGLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 249 LFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVI 328
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 329 TAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFIT-FTAYWVLGlpsgylLA 407
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQiIGTIIVVS------VA 394
|
410 420 430
....*....|....*....|....*....|....
gi 695764336 408 LTDTLVPRMGPAGFWCGFIIGLTSAAVMMMLRMR 441
Cdd:cd13135 395 LLLIFVFKLGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-401 |
2.30e-21 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 95.65 E-value: 2.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAvAIGTSIWLPAILFGHGLLLAL--TPVIAQLNGSGRRDRIAH 86
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALA-AVNLVFPIIMLLMALGLMIGVggASLISRRLGAGDREKANR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 87 QIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQ--CEGLAKTkpGMVMG 164
Cdd:cd13143 83 IFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLlrAEGKPKL--AMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 165 FIGLLVNIPVNYIFIYGhFGMpelGGIGCGVATASVYWVMFFCMISWVRRARSMrdIRSDEGFSGPDFSVLKRLVQLGLP 244
Cdd:cd13143 161 LIGAVLNIILDPLFIFV-LGL---GIAGAALATVIAQLISLLLLLLYFFRGKSL--LKLSLLRFKLSLKIIKEILALGFP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 245 IALA-LFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGV 323
Cdd:cd13143 235 SFLMqLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVAL 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695764336 324 CMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLP 401
Cdd:cd13143 315 IYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIP 392
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-445 |
2.79e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 95.74 E-value: 2.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 14 LAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIRQGFW 93
Cdd:cd13145 14 LAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 94 LAGFVSLLVMVV-LWNAGYIISSMHNIDPALAEkAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNI 172
Cdd:cd13145 94 FGIILAILLTVIgLFAAPPLFRLLGAEGDYLDL-ALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 173 PVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDEGFsgPDFSVLKRLVQLGLPIALALFFE 252
Cdd:cd13145 173 ILDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFI--PRLDVYKEILKQGFPASLNMMTI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 253 VTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVITAIF 332
Cdd:cd13145 251 GLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 333 TILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLaltdTL 412
Cdd:cd13145 331 LLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLL----VN 406
|
410 420 430
....*....|....*....|....*....|....
gi 695764336 413 VPRMGPAGFWCG-FIIGLTSAAVMMMLRMRFLQR 445
Cdd:cd13145 407 VLGLGVTGIWWGiFTIVWSAAIIALLYTRRVLKK 440
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
9-450 |
2.33e-18 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 87.10 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:PRK10189 29 REITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAG-YIISSMHN-IDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:PRK10189 109 RQSLVIMTLFAVLLAVLIHFFGeQIIDLVAGdATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLINGG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 167 GLLVNIPVNYIFIYGHFGMPELGGIGCGVA-TASVY----WVMFFCMISWVRRARsmrdIRSDEGFSGPDFSVLKRLVQL 241
Cdd:PRK10189 189 MNILNIIISSILIYGLFSWQGLGFVGAGLGlTISRYigavAIIWVLMIGFNPALR----ISLKSYFKPLNFAIIWEVMGI 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 242 GLPIALalffEVTLFAVVALL----VSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSART 317
Cdd:PRK10189 265 GIPASI----ESVLFNGGKLLtqmfVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRH 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 318 GVGVGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLL-AAIYQISDSVQVIGSGiLRGYKDTRSIFFITFTAYW 396
Cdd:PRK10189 341 VFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLnALFMPIWAASWVLPAG-LKGARDARYAMWVSMLGMW 419
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 695764336 397 VLGLPSGYLLAltdtLVPRMGPAGFWCGFIIGLTSAAVMMMLRM---RFLQRQPSSV 450
Cdd:PRK10189 420 GCRVVAGYILG----IMLGFGVVGVWMGMFLDWAVRGVLFYWRMvsgRWLWKYPRPE 472
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-443 |
5.62e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 79.58 E-value: 5.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGyLFFQVARN---QCEGlaKTKPGMVMGF 165
Cdd:cd13144 88 NNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFG-MFFQILCEkvlQSTG--NTITPMIAQL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 166 IGLLVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARsmRDIRSDEGFSGPDFSVLKRLVQLGLPI 245
Cdd:cd13144 165 IGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKN--KDVQPDLRLFRPSLRIIKEIYAVGLPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 246 ALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGV-GVC 324
Cdd:cd13144 243 IIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIaVVI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 325 MAVITAIFtILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGY 404
Cdd:cd13144 323 MLAGGLLF-QLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAW 401
|
410 420 430
....*....|....*....|....*....|....*....
gi 695764336 405 LLALTdtlvprMGPAGFWCGFIIGLTSAAVMMMLRMRFL 443
Cdd:cd13144 402 LLAKM------FGLNGVWWSFPIAEIVSFLLSLLFLKRL 434
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-405 |
1.20e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 72.34 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 8 ARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQ 87
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 88 IRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTK-PGMVMGFI 166
Cdd:cd13149 88 ATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKrPSLVMLGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 167 GLlVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVrrARSMRDIRSDEGFSGPDFSVLKRLVQLGLPIA 246
Cdd:cd13149 168 AL-VNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFL--HYHHRLIDFSEPSLKALFRSWKDILSIGIPAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 247 LALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMA 326
Cdd:cd13149 245 LSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYG 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695764336 327 VITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYL 405
Cdd:cd13149 325 AILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYV 403
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-434 |
1.33e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 72.26 E-value: 1.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13139 94 VQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLAN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 169 LVNIPVNYIFIYGHFGMPELGGIGCGVATAS-----VYWVMFFCMISWVRRARSMRDIRsdegfsgPDFSVLKRLVQLGL 243
Cdd:cd13139 174 GLNIILDPLFIFGLGPIPAMGVTGAAIATTIgrsigVLYQLYHLFKGKGRIQIRRRHLK-------LDWAIIKKIIKIAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 244 PIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFssLMFVLPLS--LAAAVTIRVGFRLGQGSTLDAQVSA-RTGVG 320
Cdd:cd13139 247 GGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRI--IMFALLPAwgLSNAAATLVGQNLGAGQPDRAEKSVwRAGKY 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 321 VGVCMAVITAIFtILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGL 400
Cdd:cd13139 325 NMVFLGIVSLVF-FLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQI 403
|
410 420 430
....*....|....*....|....*....|....
gi 695764336 401 PSGYLLALTdtlvPRMGPAGFWCGFIIGLTSAAV 434
Cdd:cd13139 404 PLAYLLARH----LNLGPKGVFIAIPIAETVLAI 433
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
7-200 |
1.00e-12 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 69.41 E-value: 1.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 7 EARQLLALAIPVILAQVAqTSMGFVD-TVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIA 85
Cdd:cd13138 223 ILKEILKIGLPSALQQSL-VSISFLIiNSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAK 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 86 HQIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGF 165
Cdd:cd13138 302 KGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISI 381
|
170 180 190
....*....|....*....|....*....|....*.
gi 695764336 166 IGL-LVNIPVnyIFIYGHFGMPELGGIGCGVATASV 200
Cdd:cd13138 382 LRLwLVRIPL--AYLLSRLTGLGLFGIWLAMPISNI 415
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
11-446 |
3.38e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 67.95 E-value: 3.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 11 LLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIRQ 90
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 91 GFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALaEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLV 170
Cdd:cd13147 91 SILLGLIISIILTIVLLPFLEPILVLMGAGEVL-DLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 171 NIPVNYIFIYGhFGMpelgGIGcGVATASVYWVMFFC--MISWVRRARSMRDIRSDEGFSgPDFSVLKRLVQLGLPIALA 248
Cdd:cd13147 170 NIILDPIFIYT-LGL----GIA-GAAWATVISMLISSlvLLYWFFVKKDTYVSLSLKNFK-FDKKIVKDILKVGIPASLE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 249 LF-FEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAV 327
Cdd:cd13147 243 QLiMSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIEL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 328 ITAIFTILMRKQIALLYNDNPEVVLLASQL---MLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGY 404
Cdd:cd13147 323 IIAILIFIFAPQIAYLFTYSEESAHLAPEIvafLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAY 402
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 695764336 405 LLAltdtLVPRMGPAGFWCGFIIGLTSAAVMMMLRMRFLQRQ 446
Cdd:cd13147 403 LFA----IVLGLGLFGVWWGIVLGNAIGSIVGYLWARLYIKR 440
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-322 |
4.19e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 67.68 E-value: 4.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 11 LLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIW-LPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIR 89
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLmLTQMMSNGAMGGGVSSAIARALGAGDRERAEALVW 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 90 QGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTK-PGMVMgFIGL 168
Cdd:cd13148 94 HALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRvPALVT-LVGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 169 LVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARSMrdIRSDEGFSGPDFSVLKRLVQLGLPIALA 248
Cdd:cd13148 173 VVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSR--LRLRLRALRLERRLFRDILRVGLLAALS 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764336 249 LFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVG 322
Cdd:cd13148 251 PLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMA 324
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
8-206 |
3.99e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 64.46 E-value: 3.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 8 ARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQ 87
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRY 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 88 IRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIG 167
Cdd:cd13137 305 GKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLIS 384
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 695764336 168 L-LVNIPVNYIFIYgHFGMPELGgigcgvatasVYWVMFF 206
Cdd:cd13137 385 MwLVRLPLAYLLGF-VLGLGLTG----------IWLAMFV 413
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
233-394 |
5.29e-10 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 60.93 E-value: 5.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 233 SVLKRLVQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQ 312
Cdd:COG0534 5 PILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEAR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 313 VSARTGVGVGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITF 392
Cdd:COG0534 85 RVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164
|
..
gi 695764336 393 TA 394
Cdd:COG0534 165 IG 166
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
9-214 |
9.52e-10 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 60.55 E-value: 9.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIW-LPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQ 87
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYqLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 88 IRQGFWLAGFVSLLVMVVLW-NAGYIISSMH---NIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVM 163
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIvLAEPIVRLLFergAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRI 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 695764336 164 GFIGLLVNIPVNYIFiyghfgMPELGGIGCGVATASVYWVMFFCMISWVRR 214
Cdd:COG0728 382 AVIAVVVNIVLNLLL------VPPLGHAGLALATSLSALVNALLLLVLLRR 426
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
8-214 |
2.42e-08 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 56.32 E-value: 2.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 8 ARQLLALAIPVILAQVAQTSMGFVDTV------MAGGYSAtDMAAVAIG-------TSIWLPAIlFGHGLLLALTPVIAQ 74
Cdd:COG5841 232 LKELLRIAIPITLSSLVLPLFQLIDSFtvprrlQAAGLSA-SEATSLYGilsgmaqPLVNLPTV-LATALATSLVPAISE 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 75 LNGSGRRDRIAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSM--HNidpalaEKAVGYLRALLWGAPGYLFFQVARNQCE 152
Cdd:COG5841 310 AFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLlfGN------PEGGGILAILAPSAIFLSLQQVTTGILQ 383
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695764336 153 GLAKTKPGMVMGFIGLLVNIPVNYIFIyghfgmPELGGIGCGVATASVYWVMFFCMISWVRR 214
Cdd:COG5841 384 GLGKQKIPVINLLIGLLVKIILNYLLV------PLFGIYGAALATVIGYLVAAILNLAALKK 439
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
11-209 |
4.65e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 54.95 E-value: 4.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 11 LLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAV-AIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQIR 89
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 90 QGFWLAGFVSLLVMVVLW-NAGYIISSMhnIDPALAEkAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:COG2244 255 KALRLLLLLGLPLALGLAlLAPPLLSLL--FGPEYAE-AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGA 331
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 695764336 169 LVNIPVNYIFIyghfgmPELGGIGCGVATASVYWVMFFCMI 209
Cdd:COG2244 332 VLNLVLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-410 |
4.98e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 55.01 E-value: 4.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGL 168
Cdd:cd13141 91 NQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 169 LVNIPVNYIFIYGHFGMPELGGIGCGVATASVYWVMFFCMISWVRRARsmRDIRSDEGFSGPDFSVLKRLVQLGLPIALA 248
Cdd:cd13141 171 LLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLE--KYLRLDLALWRPDLPTWKRLLKIGLPSGGE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 249 LFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMAVI 328
Cdd:cd13141 249 FLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALMLV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 329 TAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLAL 408
Cdd:cd13141 329 LTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALPVIWLSAQ 408
|
..
gi 695764336 409 TD 410
Cdd:cd13141 409 PD 410
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
9-214 |
1.40e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 53.63 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVM------AGGYSaTDMAAVAIG-------TSIWLPAIlFGHGLLLALTPVIAQL 75
Cdd:cd13124 224 KELLSYAIPITLSSLILPLLQLIDSFTvprrlqAAGLS-ESEATALYGiltgraqPLVQLPTV-IATALSTSLVPAISEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 76 NGSGRRDRIAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSM--HNidpalaEKAVGYLRALLWGAPGYLFFQVARNQCEG 153
Cdd:cd13124 302 YAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLlfGD------SEGGLILQILAPSILFLSLQQVTAAILQG 375
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695764336 154 LAKTKPGMVMGFIGLLVNIPVNYIFIyghfgmPELGGIGCGVATASVYWVMFFCMISWVRR 214
Cdd:cd13124 376 LGKVKIPVINLLIGLLVKIVLNYVLI------PIFGIYGAAIATVIGFLVAALLNLRALKK 430
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
9-214 |
1.68e-07 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 53.23 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIW-LPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQ 87
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYqLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRT 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 88 IRQGFWLAGFVSLLVMVVLWNAGYIISSMH----NIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVM 163
Cdd:cd13123 295 LSRGLRLVLFLLLPAAVGLIVLAEPIVRLLfergAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKI 374
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 695764336 164 GFIGLLVNIPVNYIFiyghfgMPELGGIGCGVATASVYWVMFFCMISWVRR 214
Cdd:cd13123 375 AVIAVAVNILLNLLL------IKPLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
9-135 |
7.04e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 48.01 E-value: 7.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 9 RQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDRIAHQI 88
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVA 295
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 695764336 89 RQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALL 135
Cdd:TIGR00797 296 RVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-438 |
8.35e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 47.78 E-value: 8.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 11 LLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAiGTSIWLPAIL----FGHGLLLALTPVIAQLNGSGRRDRIAH 86
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVG-GIGLVFPLGMiflaLGNGIQVGVSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 87 QIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFI 166
Cdd:cd13146 89 AADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 167 GLLVNIPVNYIFIYGhFGMpelGGIGCGVATASVYWVMFFCMISWVRRARSMRDIRSDegFSGPDFSVLKRLVQLGLPIA 246
Cdd:cd13146 169 GTVVNIVLDPILIFV-FDM---GVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIK--LSNISSSVIVEILRVGLPQM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 247 LALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDAQVSARTGVGVGVCMA 326
Cdd:cd13146 243 LLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 327 VITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLL 406
Cdd:cd13146 323 LVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLL 402
|
410 420 430
....*....|....*....|....*....|..
gi 695764336 407 AltdtLVPRMGPAGFWCGFIIGLTSAAVMMML 438
Cdd:cd13146 403 A----YVFGKGITGVYFGIVSANFFTALLAMF 430
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-186 |
8.73e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 47.91 E-value: 8.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 5 FIEARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDMAAVAIGTSI----WLPAilfgHGLLLALTPVIAQLNGSGR 80
Cdd:cd13140 227 RKYIKEILKLGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIesisWMTA----EGFSTALAAFVGQNYGAGK 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 81 RDRIAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALlwgAPGYLF--FQVARNQC-EGLAKT 157
Cdd:cd13140 303 YDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRIL---GFSQLFmcLEITTTGAfNGLGRT 379
|
170 180
....*....|....*....|....*....
gi 695764336 158 KPGMVMGFIGLLVNIPVNYIFIYGHFGMP 186
Cdd:cd13140 380 KPPAIISIVFNGLRIPLALLLSPTGLGLN 408
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
4-213 |
1.80e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 46.77 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 4 YFIEARQLLALAIPVILAQVAQTSMGFVDTVMAGGYSATDM-----AAVAIGTSIWLPAILFGhgllLALTPVIAQLNGS 78
Cdd:cd13128 201 DLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAvgiynAAYRIAELLLFIPSAIS----TALFPRISELYKN 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 79 gRRDRIAHQIRQGFWLAGFVSLLVMVVLWN-AGYIISSMHNIDPAlaeKAVGYLRALLWGAPGYLFFQVARNQCEGLAKT 157
Cdd:cd13128 277 -DKDELKKLLKKSFKYLFLISLPIAIGLFLfAEPIITLLFGEEYL---PAALVLQILAWGFLFIFLNGIFGSILQAIGKQ 352
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 695764336 158 KPGMVMGFIGLLVNIPVNYIFIyghfgmPELGGIGCGVATASVYWVMFFCMISWVR 213
Cdd:cd13128 353 KLTLKILLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-185 |
4.00e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 45.76 E-value: 4.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 5 FIEARQLLALAIPVILAQVA-QTSMGFVdTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRDR 83
Cdd:cd13149 230 FRSWKDILSIGIPAALSNILtPLSAAFI-TALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYER 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 84 IAHQIRQGFWLAGFVSLLVMVVLWNAGYIISSMHNIDPALAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVM 163
Cdd:cd13149 309 VQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGL 388
|
170 180
....*....|....*....|....*
gi 695764336 164 GFIG-LLVNIPVNYI--FIYGHFGM 185
Cdd:cd13149 389 NLIRvFLLYIPLAYVgsHLLGFAGV 413
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
233-385 |
8.11e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 44.92 E-value: 8.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695764336 233 SVLKRLVQLGLPIALALFFEvTLFAVV-ALLVSPLGIVDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTLDA 311
Cdd:cd13144 5 PVLRLLLTMSIPAMISMLFQ-ALYNIVdSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEA 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695764336 312 QVSARTGVGVGVCMAVITAIFTILMRKQIALLYNDNPEVVLLASQLMLLAAIYQISDSVQVIGSGILRGYKDTR 385
Cdd:cd13144 84 NKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTI 157
|
|
| |
