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Conserved domains on  [gi|695736253|ref|WP_032662714|]
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MULTISPECIES: cell-envelope stress modulator CpxP [Enterobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CpxP_like super family cl01482
CpxP component of the bacterial Cpx-two-component system and related proteins; This family ...
 1-167 4.58e-82

CpxP component of the bacterial Cpx-two-component system and related proteins; This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.


The actual alignment was detected with superfamily member PRK10363:

Pssm-ID: 470220  Cd Length: 166  Bit Score: 239.55  E-value: 4.58e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   1 MRKVTAAVMASTLAFSAFSQAAEAIISDNSPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPVNVSEMET 80
Cdd:PRK10363   1 MRIVTAAVMASTLAVSSLSHAAEVGTGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSEMET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253  81 MHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQLREVARMQRSSETTFFSS 160
Cdd:PRK10363  81 MHRLVTAENFDENAVRAQAEKMAQEQVARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSS 160


                 ....*..
gi 695736253 161 nSSTRSN 167
Cdd:PRK10363 161 -SNSRSQ 166
 
Name Accession Description Interval E-value
cpxP PRK10363
cell-envelope stress modulator CpxP;
1-167 4.58e-82

cell-envelope stress modulator CpxP;


Pssm-ID: 182410  Cd Length: 166  Bit Score: 239.55  E-value: 4.58e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   1 MRKVTAAVMASTLAFSAFSQAAEAIISDNSPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPVNVSEMET 80
Cdd:PRK10363   1 MRIVTAAVMASTLAVSSLSHAAEVGTGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSEMET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253  81 MHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQLREVARMQRSSETTFFSS 160
Cdd:PRK10363  81 MHRLVTAENFDENAVRAQAEKMAQEQVARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSS 160


                 ....*..
gi 695736253 161 nSSTRSN 167
Cdd:PRK10363 161 -SNSRSQ 166
CpxP COG3678
Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, ...
 2-142 5.26e-30

Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442894 [Multi-domain]  Cd Length: 141  Bit Score: 106.60  E-value: 5.26e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   2 RKVTAAVMASTLAFSAFSQAAEaiisdnsPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPV---NVSEM 78
Cdd:COG3678    3 LKLLALLLALALALGAASAFAA-------GPPGGPRGGRGLRRMLEGLNLTEEQRQQIRAIRQQYRKQMRALrqqLREAR 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695736253  79 ETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQ 142
Cdd:COG3678   76 EELRALLAADKFDEAAVRALADKIAALRAQLAVERAEARNQMYKVLTPEQRAKLAELMQERGEK 139
CpxP_like cd09916
CpxP component of the bacterial Cpx-two-component system and related proteins; This family ...
 48-140 7.35e-20

CpxP component of the bacterial Cpx-two-component system and related proteins; This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.


Pssm-ID: 197366 [Multi-domain]  Cd Length: 96  Bit Score: 79.18  E-value: 7.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253  48 GISLTEHQRQQMRDLMQRARHDQPPVNV---SEMETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLL 124
Cdd:cd09916    1 GLDLTDEQKAQIKAIRQAARAQMKALREqmrAAREELRALLTADTFDEAAVRALAAEMAELQQELAVERAKARNQIYQVL 80

                         90
                 ....*....|....*.
gi 695736253 125 TPEQQAVLNARHQQRM 140
Cdd:cd09916   81 TPEQRAKLNELFAKRR 96
LTXXQ pfam07813
LTXXQ motif family protein; This protein family includes two copies of a five residue motif is ...
 42-136 4.81e-10

LTXXQ motif family protein; This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP. This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Another member of this family, Spy is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy may indicate that these two proteins are functionally related.


Pssm-ID: 429675  Cd Length: 97  Bit Score: 53.52  E-value: 4.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   42 QSHMFDGISLTEHQRQQMRDLMQRARHDQPPVNVS--EMETMHrlvtAENFDESAVRAQA--EKMAQEQVARQVEMAKVR 117
Cdd:pfam07813   3 IAFIKAELKLTDAQRAQLDALRDAARAQAKPLKASceEMRAMR----KANFDETAPRRLAamEQMLEARLEAVKARAEAL 78

                          90
                  ....*....|....*....
gi 695736253  118 NQMFHLLTPEQQAVLNARH 136
Cdd:pfam07813  79 KQFYAILTPEQKAQFDALG 97
 
Name Accession Description Interval E-value
cpxP PRK10363
cell-envelope stress modulator CpxP;
1-167 4.58e-82

cell-envelope stress modulator CpxP;


Pssm-ID: 182410  Cd Length: 166  Bit Score: 239.55  E-value: 4.58e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   1 MRKVTAAVMASTLAFSAFSQAAEAIISDNSPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPVNVSEMET 80
Cdd:PRK10363   1 MRIVTAAVMASTLAVSSLSHAAEVGTGDNWHPGEELTQRSTQSHMFDGISLTEHQRQQMRDLMQQARHEQPPVNVSEMET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253  81 MHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQLREVARMQRSSETTFFSS 160
Cdd:PRK10363  81 MHRLVTAENFDENAVRAQAEKMAQEQVARQVEMAKVRNQMYRLLTPEQQAVLNEKHQQRMEQLRDVTQWQKSSSLKLLSS 160


                 ....*..
gi 695736253 161 nSSTRSN 167
Cdd:PRK10363 161 -SNSRSQ 166
cpxP PRK12751
periplasmic stress adaptor protein CpxP; Reviewed
 1-153 1.05e-38

periplasmic stress adaptor protein CpxP; Reviewed


Pssm-ID: 171704  Cd Length: 162  Bit Score: 129.50  E-value: 1.05e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   1 MRKVTAAVMASTL------AFSAFSQAAEAIISDNSPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPVN 74
Cdd:PRK12751   1 MRKVTTLVMASMFvlgssaAFAADNTKVTEGYHGDGKMMMNKKGDRGHHNMFDGINLTEQQRQQMRDLMRQSHQSQPRLD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695736253  75 VSEMETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQLREVARMQRSS 153
Cdd:PRK12751  81 LEDREAMHKLITADKFDEAAVRAQAEKMSQNQIERHVEMAKVRNQMYNLLTPEQKEALNKKHQERIEKLQQKPAAQPSS 159
CpxP COG3678
Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, ...
 2-142 5.26e-30

Periplasmic chaperone Spy, Spy/CpxP family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442894 [Multi-domain]  Cd Length: 141  Bit Score: 106.60  E-value: 5.26e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   2 RKVTAAVMASTLAFSAFSQAAEaiisdnsPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPV---NVSEM 78
Cdd:COG3678    3 LKLLALLLALALALGAASAFAA-------GPPGGPRGGRGLRRMLEGLNLTEEQRQQIRAIRQQYRKQMRALrqqLREAR 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695736253  79 ETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQ 142
Cdd:COG3678   76 EELRALLAADKFDEAAVRALADKIAALRAQLAVERAEARNQMYKVLTPEQRAKLAELMQERGEK 139
PRK10455 PRK10455
periplasmic protein; Reviewed
 1-142 4.71e-24

periplasmic protein; Reviewed


Pssm-ID: 182473  Cd Length: 161  Bit Score: 91.79  E-value: 4.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   1 MRKVTAAVMASTLAFSAFS--QAAEAII----SDNSPLQEGATQNSSQSHMFDGISLTEHQRQQMRDLMQRARHDQPPVN 74
Cdd:PRK10455   1 MRKLTALFVASTLALGAANlaHAADTTTappaDAKPMMHHKGKFGPHHDMMFKGLNLTDAQKQQIRDIMKAQRDQMKRPP 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695736253  75 VSEMETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQAVLNARHQQRMDQ 142
Cdd:PRK10455  81 LEERRAMHDIIASDTFDKAKAEAQITKMEAQRKARMLAHMETQNKIYNVLTPEQKKQFNANFEKRLTE 148
CpxP_like cd09916
CpxP component of the bacterial Cpx-two-component system and related proteins; This family ...
 48-140 7.35e-20

CpxP component of the bacterial Cpx-two-component system and related proteins; This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family.


Pssm-ID: 197366 [Multi-domain]  Cd Length: 96  Bit Score: 79.18  E-value: 7.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253  48 GISLTEHQRQQMRDLMQRARHDQPPVNV---SEMETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLL 124
Cdd:cd09916    1 GLDLTDEQKAQIKAIRQAARAQMKALREqmrAAREELRALLTADTFDEAAVRALAAEMAELQQELAVERAKARNQIYQVL 80

                         90
                 ....*....|....*.
gi 695736253 125 TPEQQAVLNARHQQRM 140
Cdd:cd09916   81 TPEQRAKLNELFAKRR 96
cpxP PRK12750
periplasmic repressor CpxP; Reviewed
 50-142 4.59e-10

periplasmic repressor CpxP; Reviewed


Pssm-ID: 183722 [Multi-domain]  Cd Length: 170  Bit Score: 55.23  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253  50 SLTEHQRQQMRDLMQRARHDQPPVNVSEMETMHRLVTAENFDESAVRAQAEKMAQEQVARQVEMAKVRNQMFHLLTPEQQ 129
Cdd:PRK12750  63 EMREANRAEMKAKYSGNREQSHAEMKAHHAKVQALVLADDFDEAAANDLAKQMVEKQVERRVKMLEKRHQMLSILTPEQK 142

                         90
                 ....*....|...
gi 695736253 130 AVLNARHQQRMDQ 142
Cdd:PRK12750 143 AKFQELQQERMQE 155
LTXXQ pfam07813
LTXXQ motif family protein; This protein family includes two copies of a five residue motif is ...
 42-136 4.81e-10

LTXXQ motif family protein; This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP. This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH. Another member of this family, Spy is also a periplasmic protein that may be involved in the response to stress. The homology between CpxP and Spy may indicate that these two proteins are functionally related.


Pssm-ID: 429675  Cd Length: 97  Bit Score: 53.52  E-value: 4.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695736253   42 QSHMFDGISLTEHQRQQMRDLMQRARHDQPPVNVS--EMETMHrlvtAENFDESAVRAQA--EKMAQEQVARQVEMAKVR 117
Cdd:pfam07813   3 IAFIKAELKLTDAQRAQLDALRDAARAQAKPLKASceEMRAMR----KANFDETAPRRLAamEQMLEARLEAVKARAEAL 78

                          90
                  ....*....|....*....
gi 695736253  118 NQMFHLLTPEQQAVLNARH 136
Cdd:pfam07813  79 KQFYAILTPEQKAQFDALG 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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