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Conserved domains on  [gi|695705843|ref|WP_032641181|]
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MULTISPECIES: membrane-bound lytic murein transglycosylase EmtA [Enterobacter]

Protein Classification

membrane-bound lytic murein transglycosylase EmtA( domain architecture ID 11487811)

membrane-bound lytic murein transglycosylase EmtA is a murein-degrading enzyme that may play a role in recycling of muropeptides during cell elongation and/or cell division

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.97e-155

membrane-bound lytic murein transglycosylase EmtA;


:

Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.46  E-value: 2.97e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843   1 MKLRWFAFLIVLLAGCSSKHDYQNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  81 MQLKASTAGKEVYRYMGWSGQPSTSELKNPERNISMGTAYLSIMEHGVLKGIKDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 695705843 161 RKEAIEEINDMDKDEFFEHVAKNHPAPQAPRYIWKVQKAMDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.97e-155

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.46  E-value: 2.97e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843   1 MKLRWFAFLIVLLAGCSSKHDYQNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  81 MQLKASTAGKEVYRYMGWSGQPSTSELKNPERNISMGTAYLSIMEHGVLKGIKDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 695705843 161 RKEAIEEINDMDKDEFFEHVAKNHPAPQAPRYIWKVQKAMDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-200 1.70e-81

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 239.38  E-value: 1.70e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  41 PISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGKEVYRYMGWSGQ-PSTSELKNPERNISMGTA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843 120 YLSIMEHGVLKGIKDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINDMDKDEFFEHVAKNHPAPQAPRYIWKVQKA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                 .
gi 695705843 200 M 200
Cdd:cd16893  161 K 161
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-203 4.11e-31

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 113.55  E-value: 4.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  23 QNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgKEVYRYMGWSgqP 102
Cdd:COG0741   87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKLGLG--P 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843 103 STSELKNPERNISMGTAYLSIMeHGVLKGikdpevmQYALVV-SYVNGAGALLRTFSSDRKEAIEEIndmdkdeffehva 181
Cdd:COG0741  164 SPDDLFDPETNIRAGAAYLREL-LDRFDG-------DLVLALaAYNAGPGRVRRWLRRNGDRDGEII------------- 222

                        170       180
                 ....*....|....*....|..
gi 695705843 182 knhPAPQAPRYIWKVQKAMDAM 203
Cdd:COG0741  223 ---PYAETRNYVKKVLANYAIY 241
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 8.03e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 101.23  E-value: 8.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843   45 QAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGKEVYRymgwsGQPSTSELKNPERNISMGTAYLSIM 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR-----VNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 695705843  125 ehgvlkgIKDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEI 168
Cdd:pfam01464  78 -------YKQYGGDLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 2.97e-155

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.46  E-value: 2.97e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843   1 MKLRWFAFLIVLLAGCSSKHDYQNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  81 MQLKASTAGKEVYRYMGWSGQPSTSELKNPERNISMGTAYLSIMEHGVLKGIKDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 695705843 161 RKEAIEEINDMDKDEFFEHVAKNHPAPQAPRYIWKVQKAMDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-200 1.70e-81

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 239.38  E-value: 1.70e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  41 PISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGKEVYRYMGWSGQ-PSTSELKNPERNISMGTA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843 120 YLSIMEHGVLKGIKDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINDMDKDEFFEHVAKNHPAPQAPRYIWKVQKA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                 .
gi 695705843 200 M 200
Cdd:cd16893  161 K 161
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
34-199 4.42e-57

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 183.71  E-value: 4.42e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGKEVYRYMGWSGQPSTSELKNPERN 113
Cdd:PRK11671 187 KRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMKGKSGQPSRSYLFDPANN 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843 114 ISMGTAYLSIMEHGVLKGIKDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINDMDKDEFFEHVAKNHPAPQAPRYI 193
Cdd:PRK11671 267 IDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRHPSAESRRYL 346


                 ....*.
gi 695705843 194 WKVQKA 199
Cdd:PRK11671 347 YKVNTA 352
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-203 4.11e-31

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 113.55  E-value: 4.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  23 QNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgKEVYRYMGWSgqP 102
Cdd:COG0741   87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKLGLG--P 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843 103 STSELKNPERNISMGTAYLSIMeHGVLKGikdpevmQYALVV-SYVNGAGALLRTFSSDRKEAIEEIndmdkdeffehva 181
Cdd:COG0741  164 SPDDLFDPETNIRAGAAYLREL-LDRFDG-------DLVLALaAYNAGPGRVRRWLRRNGDRDGEII------------- 222

                        170       180
                 ....*....|....*....|..
gi 695705843 182 knhPAPQAPRYIWKVQKAMDAM 203
Cdd:COG0741  223 ---PYAETRNYVKKVLANYAIY 241
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 8.03e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 101.23  E-value: 8.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843   45 QAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGKEVYRymgwsGQPSTSELKNPERNISMGTAYLSIM 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLR-----VNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 695705843  125 ehgvlkgIKDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEI 168
Cdd:pfam01464  78 -------YKQYGGDLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 54-124 8.69e-18

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 75.33  E-value: 8.69e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695705843  54 PRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgkevyrymGWSGQPSTSELKNPERNISMGTAYLSIM 124
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTA--------RDLGRRGVDDLFDPEENIRAGARYLREL 63
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 44-122 1.50e-17

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 75.62  E-value: 1.50e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695705843  44 EQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgKEVYRYMGWSGqPSTSELKNPERNISMGTAYLS 122
Cdd:cd16896    9 EKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETA-EWIAEKLGLED-FSEDDLYDPETNIRLGTWYLS 85
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 37-122 5.48e-17

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 74.05  E-value: 5.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  37 MQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgKEVYRYMGWSGqPSTSELKNPERNISM 116
Cdd:cd13401    4 LPYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATA-KDVAKKLGLPY-YSPRDLFDPEYNIRL 81


                 ....*.
gi 695705843 117 GTAYLS 122
Cdd:cd13401   82 GSAYLA 87
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 44-155 8.84e-15

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 68.72  E-value: 8.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  44 EQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgkevyRYMGwsgqpsTSELKNPERNISMGTAYLSI 123
Cdd:cd13403    2 KKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA-----RELG------VNDRLDPEQNIHAGAKYLRY 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 695705843 124 MEHGVLKGIKDPEVMQYALvVSYVNGAGALLR 155
Cdd:cd13403   71 LRDRFPPDIDEPDRLKFAL-AAYNAGPGHVRD 101
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 34-164 2.81e-14

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 70.48  E-value: 2.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgkevyRYMGwsgqpsTSELKNPERN 113
Cdd:COG4623  259 GRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATA-----KELG------VDDRLDPEQS 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695705843 114 ISMGTAYLSIMEHGVLKGIKDPEVMQYALvVSYVNGAGALLRtfssDRKEA 164
Cdd:COG4623  328 IRAGAKYLRWLYDRFPEAIDEPDRWWFAL-AAYNAGPGHVQD----ARRLA 373
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 39-121 6.60e-08

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 51.99  E-value: 6.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  39 WMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGKEVYRYmGWSGQPSTSELKNPERNISMGT 118
Cdd:PRK11619 479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVKMF-SIPGYSSSSQLLDPETNINIGT 557


                 ...
gi 695705843 119 AYL 121
Cdd:PRK11619 558 SYL 560
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 50-129 4.56e-07

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 46.75  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  50 WGVSPRLITAIIAVESGGNPTLVSKSN----AVGLMQLKaSTAGKEVYRYmgwsGQPSTSELKNPERNISMGTAYLS--I 123
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQIN-SIWLPELARY----GITREELLNDPCTNIYVGAWILArnI 75


                 ....*.
gi 695705843 124 MEHGVL 129
Cdd:cd13400   76 KRYGNT 81
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 50-88 1.20e-04

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 39.98  E-value: 1.20e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 695705843  50 WGVSPRLITAIIAVESGGNPTLV-SKSNAVGLMQLKASTA 88
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTW 40
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
38-154 1.37e-04

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 41.78  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  38 QWMPISEQAGKawGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgkevyRYMGwsgqpstseLKN---PERNI 114
Cdd:PRK10859 289 KYQPLFEKYAG--ELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTA-----QSMG---------VTDrldPEQSI 352

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695705843 115 SMGTAYLSIMEHGVLKGIKDPEVMQYALvVSYVNGAGALL 154
Cdd:PRK10859 353 RGGARYLQDLMERLPESIPEPERIWFAL-AAYNIGYGHML 391
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 34-134 4.24e-04

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 39.51  E-value: 4.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705843  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSK-----SNAVGLMQLKAstagkevyRYMGWSGQPSTSElk 108
Cdd:cd01021   32 NRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALDKNgwgdhGNGFGLMQVDK--------RYHPPKGAWDSEE-- 101

                         90       100
                 ....*....|....*....|....*.
gi 695705843 109 nperNISMGTAYLSIMehgvLKGIKD 134
Cdd:cd01021  102 ----HIEQATGILIDF----IKTVQR 119
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 63-88 1.09e-03

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 37.50  E-value: 1.09e-03
                         10        20
                 ....*....|....*....|....*.
gi 695705843  63 VESGGNPTLVSKSNAVGLMQLKASTA 88
Cdd:cd16894   16 VESGFNPDAVSSAGAAGLWQFMPATA 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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