NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|695705639|ref|WP_032641077|]
View 

MULTISPECIES: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Enterobacter cloacae complex]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 17614445)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-283 1.20e-135

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 385.33  E-value: 1.20e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639    1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLLTPVDGVAHEDNLIVRAARLLMSAAAQ 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   81 SgrLPAGSGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:TIGR00154  81 K--IKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  161 TP-AEPPEKWYLVAHPGVSIPTPVIFKDPDLKRNTPIRS----------IKTLLNCEFSNDCEDIARKRFREVDAVLSWL 229
Cdd:TIGR00154 159 TPfEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAkewlkkisleCLQLLDSNGLNDLEKVALKRHTEVAQALNWL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 695705639  230 LEY--APSRLTGTGACVFAEFDTESAARQVLEQAPDWLHGFVARGMNTSPLQQAIL 283
Cdd:TIGR00154 239 LEYglAPERMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIGRAML 294
 
Name Accession Description Interval E-value
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-283 1.20e-135

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 385.33  E-value: 1.20e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639    1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLLTPVDGVAHEDNLIVRAARLLMSAAAQ 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   81 SgrLPAGSGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:TIGR00154  81 K--IKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  161 TP-AEPPEKWYLVAHPGVSIPTPVIFKDPDLKRNTPIRS----------IKTLLNCEFSNDCEDIARKRFREVDAVLSWL 229
Cdd:TIGR00154 159 TPfEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAkewlkkisleCLQLLDSNGLNDLEKVALKRHTEVAQALNWL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 695705639  230 LEY--APSRLTGTGACVFAEFDTESAARQVLEQAPDWLHGFVARGMNTSPLQQAIL 283
Cdd:TIGR00154 239 LEYglAPERMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIGRAML 294
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-274 2.33e-122

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 350.96  E-value: 2.33e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   2 MTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLLTPVDGV-AHEDNLIVRAARLLmsaAAQ 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVpTDEDNLVYRAARLL---QEA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  81 SGRLPagsGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:COG1947   78 TGIPP---GVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639 161 TPAEP-PEKWYLVAHPGVSIPTPVIFKDPDLKRNTPIRSIKTLLNC----------EFSNDCEDIARKRFREVDAVLSWL 229
Cdd:COG1947  155 TPLPPlPELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAAlaagdaalaaLLRNDLEPVAFKLYPEIAEVLEAL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 695705639 230 LEYA--PSRLTGTGACVFAEFDTESAARQVLEQAPDWLHGFVARGMN 274
Cdd:COG1947  235 LEAGalAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-273 1.37e-56

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 183.90  E-value: 1.37e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQiclLTpVDG------VAHEDNLIVRAARLL 74
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAEALS---LT-VSGpfaaglGDGDDNLVLRAARAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  75 msAAAQSGRLPAGSgadIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAE 154
Cdd:PRK14608  81 --RARVGPGLPPGA---FHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639 155 GVGEILTPAEP-PEKWYLVAHPGVSIPTPVIFKDPDLKRN-------TPIRSIKTLLNC--EFSNDCEDIARKRFREVDA 224
Cdd:PRK14608 156 GIGEELTPLPGlPSLPAVLVNPGVPVATPDVFRALGLRDGpplpgapDPLASADALLAAlaATRNDLEPPALALAPVIGE 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 695705639 225 VLSWLLEYAPSRLT---GTGACVFAEFDTESAARQ----VLEQAPDWlhgFVARGM 273
Cdd:PRK14608 236 VLAALRAQPGALLArmsGSGATCFALFADEAAAEAaaaaIAAAHPGW---WVKATR 288
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 91-148 1.16e-04

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 39.45  E-value: 1.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695705639   91 DIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGC-----GLSQDELAALGLTLGADVPVFVRG 148
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLplaklALEAEELAGGGRGGGMDVAASLYG 63
 
Name Accession Description Interval E-value
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-283 1.20e-135

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 385.33  E-value: 1.20e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639    1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLLTPVDGVAHEDNLIVRAARLLMSAAAQ 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   81 SgrLPAGSGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:TIGR00154  81 K--IKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  161 TP-AEPPEKWYLVAHPGVSIPTPVIFKDPDLKRNTPIRS----------IKTLLNCEFSNDCEDIARKRFREVDAVLSWL 229
Cdd:TIGR00154 159 TPfEDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAkewlkkisleCLQLLDSNGLNDLEKVALKRHTEVAQALNWL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 695705639  230 LEY--APSRLTGTGACVFAEFDTESAARQVLEQAPDWLHGFVARGMNTSPLQQAIL 283
Cdd:TIGR00154 239 LEYglAPERMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIGRAML 294
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-274 2.33e-122

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 350.96  E-value: 2.33e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   2 MTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLLTPVDGV-AHEDNLIVRAARLLmsaAAQ 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVpTDEDNLVYRAARLL---QEA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  81 SGRLPagsGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:COG1947   78 TGIPP---GVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639 161 TPAEP-PEKWYLVAHPGVSIPTPVIFKDPDLKRNTPIRSIKTLLNC----------EFSNDCEDIARKRFREVDAVLSWL 229
Cdd:COG1947  155 TPLPPlPELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAAlaagdaalaaLLRNDLEPVAFKLYPEIAEVLEAL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 695705639 230 LEYA--PSRLTGTGACVFAEFDTESAARQVLEQAPDWLHGFVARGMN 274
Cdd:COG1947  235 LEAGalAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-273 1.37e-56

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 183.90  E-value: 1.37e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQiclLTpVDG------VAHEDNLIVRAARLL 74
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAEALS---LT-VSGpfaaglGDGDDNLVLRAARAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  75 msAAAQSGRLPAGSgadIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAE 154
Cdd:PRK14608  81 --RARVGPGLPPGA---FHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639 155 GVGEILTPAEP-PEKWYLVAHPGVSIPTPVIFKDPDLKRN-------TPIRSIKTLLNC--EFSNDCEDIARKRFREVDA 224
Cdd:PRK14608 156 GIGEELTPLPGlPSLPAVLVNPGVPVATPDVFRALGLRDGpplpgapDPLASADALLAAlaATRNDLEPPALALAPVIGE 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 695705639 225 VLSWLLEYAPSRLT---GTGACVFAEFDTESAARQ----VLEQAPDWlhgFVARGM 273
Cdd:PRK14608 236 VLAALRAQPGALLArmsGSGATCFALFADEAAAEAaaaaIAAAHPGW---WVKATR 288
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
7-246 7.30e-34

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 124.48  E-value: 7.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   7 SPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLLTPVdgVAHEDNLIVRAARLLMSAaaqSGRLPA 86
Cdd:PRK14611   6 SPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHHTLEVKTSSPQ--IKEEENIVYKALRLFERY---TGIDIN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  87 GSgadIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEILTPAEPP 166
Cdd:PRK14611  81 YS---IFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLEKP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639 167 --EKWYLVaHPGVSIPTPVIF----------KDPDLKRNTPIRSIKTLLNCEF-SNDCEDIARKRFREVDAVLSWL--LE 231
Cdd:PRK14611 158 isREITLV-YPNIKSSTGRVYskvtkqiltnKEDLNIIISLLREGEEKKIEEViENTLGEIALELYPEIKEVYRFLeyLG 236

                        250
                 ....*....|....*
gi 695705639 232 YAPsRLTGTGACVFA 246
Cdd:PRK14611 237 YKP-FVSGSGSSVYV 250
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 8-189 2.12e-29

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 113.06  E-value: 2.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   8 PAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAieLRQDGQICLLTPVDGVAH----EDNLIVRAARLLmsaAAQSGR 83
Cdd:PRK03188   6 PAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVT--VTAADVLSVEVSGEGADQvptdESNLAWRAAELL---AEHVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  84 LPagsGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRGHAAFAEGVGEILTPA 163
Cdd:PRK03188  81 AP---DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPV 157

                        170       180
                 ....*....|....*....|....*....
gi 695705639 164 EPPEKWYLV---AHPGVSipTPVIFKDPD 189
Cdd:PRK03188 158 LARGTFHWVlafADGGLS--TPAVFRELD 184
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 9-186 1.55e-22

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 93.87  E-value: 1.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   9 AKLNLFLYITGQRaDGYHTLQTLFQFI-DYGDTIAIELRQDGQICLLTPVDgVAHEDNLIVRAARLLMSAAAQSGRLPAG 87
Cdd:PRK04181   7 AKVNIFLKILGKR-GNYHELISRFVLVkDLFDEIEFVPKSAESFELIGNFD-CPLEENIIYKAYQELKNKGFSNELIEFF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  88 SGADIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGCGLSQDELAALGLTLGADVPVFVRG-HAAFAEGVGEILTP--AE 164
Cdd:PRK04181  85 KKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEEfeEE 164

                        170       180
                 ....*....|....*....|...
gi 695705639 165 PPE-KWYLvahPGVSIPTPVIFK 186
Cdd:PRK04181 165 ILNlEIFT---PNIFCSTKAVYK 184
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
7-260 4.79e-20

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 87.65  E-value: 4.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   7 SPAKLNLFLYITGQRADGYHTLQTLFQFIDYGDTIAIELRQDGQICLltpvdgvaHEDNLIVRAARLLMSAAAQSGRL-- 84
Cdd:PRK14613   3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFEL--------FSTNEIILEKRKLYDQVSERGDIkq 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  85 --------------PAGSGADIRIEKRLPMGGGLGGGSSNAATVlvaLNHL--WGCGLSQDELAALGLTLGADVPVFVRG 148
Cdd:PRK14613  75 nilyktfikarslfPELPGVKIHLTKRISPAGGLGGGSTNAASL---LNFLfsWRNFFTSDEMQVFAKEIGSDVPFFLGE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639 149 HAAFAEGVGEILTPAEPPEKWYLVAHPGVSIPTPVIF-------KDPDLKRN------TPIRSIKT----LLNCEFSNDC 211
Cdd:PRK14613 152 GHAFVTGKGEIMEEIEVHKGQGILALTPQVMNTGEMYallkkplQESASQKNgntlseDLISSLKVgdwvSLQGRLENDF 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695705639 212 EDIARKRFREVDAVLSWLLEYAPS--RLTGTGACVFAEFDTESAARQVLEQ 260
Cdd:PRK14613 232 EPVAFQLHPELGVLKDKFLEFGSSycSLTGSGSSMYGLVQGLEIQEELLPR 282
PRK01212 PRK01212
homoserine kinase; Provisional
 63-181 7.47e-06

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 46.68  E-value: 7.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  63 EDNLIVRAARLLMSAAaqsGRLPagsGADIRIEKRLPMggglgggSSNAATV--LVALNHLWGCGLSQDEL--------- 131
Cdd:PRK01212  61 EKNLVYQAALKFLEKL---GKPP---GLRIELEKNIPLgrg--lgSSAASIVagLVAANELAGLPLSKEELlqlategeg 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695705639 132 ------AAL--GLTLGADVPvfvrghaafaegvGEILTPAEPPEKWYLV-AHPGVSIPT 181
Cdd:PRK01212 133 hpdnvaPALlgGLVLALEEN-------------GVISVKIPVFDDLKWVvAIPNIELST 178
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 91-148 1.16e-04

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 39.45  E-value: 1.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695705639   91 DIRIEKRLPMGGGLGGGSSNAATVLVALNHLWGC-----GLSQDELAALGLTLGADVPVFVRG 148
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLplaklALEAEELAGGGRGGGMDVAASLYG 63
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 188-266 1.67e-04

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 39.76  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639  188 PDLKRNTPIRSIKTLLNCEFSNDCEDIARKRFREVDAVLSWLLEY-APSRLTGT--GACVFAEFDTESAARQVLEQAPDW 264
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLEPLLVVGILPPELDELLEALLELgLGAKLSGSggGPTVFALFKDEDDAEEVARALREA 82


                  ..
gi 695705639  265 LH 266
Cdd:pfam08544  83 GK 84
PRK03926 PRK03926
mevalonate kinase; Provisional
 2-135 4.29e-04

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 41.19  E-value: 4.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695705639   2 MTHWPSPAKLNLFlyitgqradGYHTlqtlfqfIDYGDTI---AIELR-------QDGQICLLTPVdGVAHEDNLIVRAA 71
Cdd:PRK03926   1 MVLCSAPGKIYLF---------GEHA-------VVYGKPAiacAIDLRtyvraefNDDSIYIESDY-GKTGEKHPYVSAA 63

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695705639  72 RLLMSAAAqsgrlpAGSGADIRIEKRLPMGGGLGggSSNAATV--LVALNHLWGCGLSQDELAALG 135
Cdd:PRK03926  64 IEKMREEA------DKDGVTVSITSQIPVGSGLG--SSAAVTVatIGALNRLLGLGLSLEEIAKLG 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH