|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
9-352 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 682.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 9 MDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHIRE 88
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 89 IFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVITPEE 168
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 169 VPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVGVERT 248
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 249 LSEDIHDWSECECIItEQLYPELERRLSKVKPDLLIARQGIKLKFNDFQQTTQEHVWPRLNKDDLIATAKKAWEERRGGR 328
Cdd:PRK02406 241 FAEDLYDLEACLAEL-PRLAEKLERRLERAKPDKRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLGGR 319
|
330 340
....*....|....*....|....
gi 695700134 329 GVRLVGLHVTLLDPQLERQLVLGL 352
Cdd:PRK02406 320 GVRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
5-340 |
2.60e-177 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 494.73 E-value: 2.60e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASL 84
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS-DRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 85 HIREIFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVI 164
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 165 TPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVG 244
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 245 VERTLSEDIHDWSECECIITEqLYPELERRLSKVKpdLLIARQGIKLKFNDFQQTTQE--HVWPRLNKDDLIATAKKAWE 322
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLE-LAEELAERLRKRG--LKGRTVTVKLKYADFSTRTRSrtLPEPTDDAEDIYELALELLE 316
|
330
....*....|....*...
gi 695700134 323 ERRGGRGVRLVGLHVTLL 340
Cdd:cd03586 317 ELLDGRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
2-338 |
3.18e-156 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 441.51 E-value: 3.18e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKE 81
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 82 ASLHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 162 YVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRK 241
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 242 SVGVERTLSEDIHDWSECECIITEqLYPELERRLSKVkpDLLIARQGIKLKFNDFQQTTQEHVWPR--LNKDDLIATAKK 319
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEAALRR-LAERLAERLRRQ--GLGARTVTVKLRTSDFRTTTRSRTLPEptDDTAELLRAARE 316
|
330 340
....*....|....*....|
gi 695700134 320 AWEER-RGGRGVRLVGLHVT 338
Cdd:COG0389 317 LLERIyRPGRPVRLLGVRLS 336
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
1-350 |
8.51e-101 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 301.25 E-value: 8.51e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYK 80
Cdd:PRK14133 2 DRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGIS-ERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDsvhCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:PRK14133 81 EVSKNIFKILYEVTPIVEPVSIDEAYLDITN---IKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 161 QYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLR 240
Cdd:PRK14133 158 IKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRER 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 241 KSVGVERTLSEDIHDWSEceciITEQLYpelerRLSKVKPDLLIARQ------GIKLKFNDFQQTTQEHVwprLNK---- 310
Cdd:PRK14133 238 KSIGKETTLKKDTKDKEE----LKKYLK-----DFSNIISEELKKRNlygktvTVKIKTSDFQTHTKSKT---LNDyird 305
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 695700134 311 -DDLIATAKKAWEERRGGRGVRLVGLHVTLLDPQLERQLVL 350
Cdd:PRK14133 306 kEEIYNVACEILEHINIKEPIRLIGLSVSNLSENKIEQLSF 346
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-346 |
1.18e-98 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 298.00 E-value: 1.18e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 4 IIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvqRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEAS 83
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGGK--RGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 84 LHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHGS--ATLMAQEIRQtIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGAppAVVLARFARR-VEREIGITVSVGLSYNKFLAKIASDLDKPRGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 162 YVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRK 241
Cdd:PRK02794 195 SVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAK 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 242 SVGVERTLSEDIHDWSECECIiteqLYPELERRLSKVKPDLLIARQ-GIKLKFNDFQQTTQEHvwpRLNK-----DDLIA 315
Cdd:PRK02794 275 SVSAETTFETDLSDFEDLEPI----LWRLSEKVSRRLKAAGLAGRTvTLKLKTADFRLRTRRR---TLEDptqlaDRIFR 347
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695700134 316 TAKKAWEERRGGRGVRLVGLHVT------------LLDPQLER 346
Cdd:PRK02794 348 TARELLEKETDGTAFRLIGIGVSdlspadeadppdLLDPQATR 390
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
2-341 |
3.32e-92 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 281.15 E-value: 3.32e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGS-RVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYK 80
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNeKERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDSVHChGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:PRK01810 85 EASRQMFQILSEFTPLVQPVSIDEGYLDITDCYAL-GSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 161 QYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERL- 239
Cdd:PRK01810 164 ITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPEAIy 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 240 -RKSVGVERTLSEDIHDWSECECIITeQLYPELERRLSKVKpdLLIARQGIKLKFNDFQQTTQEHVW--PRLNKDDLIAT 316
Cdd:PRK01810 244 qFKSVGNSTTLSHDMDEEKELLDVLR-RLSKSVSKRLQKKT--VVSYNVQIMIRYHDRRTITRSKTLknPIWEKRDIFQA 320
|
330 340
....*....|....*....|....*
gi 695700134 317 AKKAWEERRGGRGVRLVGlhVTLLD 341
Cdd:PRK01810 321 ASRLFKQHWNGDPVRLLG--VTATD 343
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
1-334 |
5.97e-79 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 248.70 E-value: 5.97e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLT-LLPGRFEAY 79
Cdd:PRK03348 4 QRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLG-GRGVVAGASYEARVFGARSAMPMHQARRLVGNGAvVLPPRFVVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 80 KEASLHIREIFARYTSLIEPLSLDEAYLD----VTDSVhchGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDL 155
Cdd:PRK03348 83 RAASRRVFDTLRELSPVVEQLSFDEAFVEpaelAGASA---EEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 156 NKPNGQYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQR---SDLAMLLKRfgKFGRVLWERSQGIDDR 232
Cdd:PRK03348 160 AKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAAlseAEVANLLGA--TVGPALHRLARGIDDR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 233 DVNSERLRKSVGVERTLSEDIHDWSECECIItEQLYPELERRLSKvkpDLLIARQ-GIKLKFNDFQQTTQEHV--WPRLN 309
Cdd:PRK03348 238 PVAERAEAKQISAESTFAVDLTTRAQLREAI-ERIAEHAHRRLLK---DGRGARTvTVKLRKSDFSTLTRSATlpYATDD 313
|
330 340
....*....|....*....|....*
gi 695700134 310 KDDLIATAKKAWEERRGGRGVRLVG 334
Cdd:PRK03348 314 AAVLAATARRLLLDPDEIGPIRLVG 338
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
2-292 |
3.53e-78 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 245.30 E-value: 3.53e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 2 RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKE 81
Cdd:cd01701 47 RIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAYEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 82 ASLHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHG-SATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:cd01701 127 VSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 161 QYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAM--LLKRFG-KFGRVLWERSQGIDDRDVNSE 237
Cdd:cd01701 207 QYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSKTKekLQKVLGpKTGEKLYDYCRGIDDRPVTGE 286
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 238 RLRKSVGVE-----RTLSEDihdwsECECIItEQLYPELERRLSKVKpdlLIARQgIKLK 292
Cdd:cd01701 287 KERKSVSAEinygiRFTNVD-----DVEQFL-QRLSEELSKRLEESN---VTGRQ-ITLK 336
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
4-350 |
6.99e-76 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 239.12 E-value: 6.99e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 4 IIHVDMDCFFAAVEMRDNPALRDIPIAIGGsrvqrGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEAS 83
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 84 LHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNGQYV 163
Cdd:PRK03858 81 KAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 164 ITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGK-FGRVLWERSQGIDDRDVNSERLRKS 242
Cdd:PRK03858 161 VPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPaAGRHLHALAHNRDPRRVETGRRRRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 243 VGVERTLSEDIHDWSECECIITeQLYPELERRLSKVkpdlliARQG----IKLKFNDFQQTTQEHVWPRLNKD------- 311
Cdd:PRK03858 241 VGAQRALGRGPNSPAEVDAVVV-ALVDRVARRMRAA------GRTGrtvvLRLRFDDFTRATRSHTLPRPTAStatllaa 313
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 695700134 312 --DLIATAKKAWEErrggRGVRLVGLHVTLLDPQLERQLVL 350
Cdd:PRK03858 314 arDLVAAAAPLIAE----RGLTLVGFAVSNLDDDGAQQLEL 350
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
1-350 |
2.93e-73 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 232.59 E-value: 2.93e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRVQR-GVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAY 79
Cdd:PRK03103 2 ERVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRsGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 80 KEASLHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDL---N 156
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNfakK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 157 KPNGQYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNS 236
Cdd:PRK03103 162 NPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSPVTP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 237 ERL--RKSVGVERTLSEDIHDWSECECIITEqLYPELERRlskvkpdlliARQG--------IKLKFNDFQQTTQEHVWP 306
Cdd:PRK03103 242 HSLdrQKAIGHQMTLPRDYRGFEEIKVVLLE-LCEEVCRR----------ARAKgymgrtvsVSLRGADFDWPTGFSRQM 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 695700134 307 RLNK-----DDLIATAKKAWEERRGGRGVRLVGLHVTLLDPQLERQLVL 350
Cdd:PRK03103 311 TLPEptnlaMEVYEAACKLFHRHWDGKPVRRVGVTLSNLVSDDVWQLSL 359
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-275 |
9.98e-69 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 218.77 E-value: 9.98e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 6 HVDMDCFFAAVEMRDNPALRDIPIAIGGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLH 85
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 86 IREIFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELN-LTASAGVAPVKFLAKIASDLNKPNGQYVI 164
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 165 TPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQR-SDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSV 243
Cdd:cd00424 162 DPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAaSPDALLALWGGVSGERLWYALRGIDDEPLSPPRPRKSF 241
|
250 260 270
....*....|....*....|....*....|..
gi 695700134 244 GVERTLSEDIHDWSECECIItEQLYPELERRL 275
Cdd:cd00424 242 SHERVLPRDSRNAEDARPLL-RLLLEKLARRL 272
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
7-154 |
1.28e-63 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 198.95 E-value: 1.28e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 7 VDMDCFFAAVEMRDNPALRDIPIAIGGSrVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHI 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695700134 87 REIFARYTS-LIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASD 154
Cdd:pfam00817 80 FEILRRFSTpKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
6-277 |
9.28e-54 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 180.59 E-value: 9.28e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 6 HVDMDCFFAAVEMRDNPALRDIPIAIggsrVQRGVISTANYPARKFGVRSAMPTAMALKLCPHL------TLLPGRFEA- 78
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV----VQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLilahvaTYKKGEDEAd 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 79 ----------------YKEASLHIREIFARYTSLIEPLSLDEAYLDVTDSVhchgsatlmAQEIRQTIFNELNLTASAGV 142
Cdd:cd01702 78 yhenpsparhkvsldpYRRASRKILNILKRFGDVVEKASIDEAYLDLGSRI---------VEEIRQQVYDELGYTCSAGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 143 APVKFLAKIASDLNKPNGQYVITPEEVPAFLKTLPLGKIPGV-GKVSAAKLENMGLRT-CEDVQRSDLAMLLKR--FGKF 218
Cdd:cd01702 149 AHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTeGDVAGFRSSESDLQEhfGEKL 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695700134 219 GRVLWERSQGIDDRDVNSERLRKSVGVERTLS-------EDIHDWsececiiTEQLYPELERRLSK 277
Cdd:cd01702 229 GEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFPgktalstEDVQHW-------LLVLASELNSRLED 287
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
5-323 |
2.31e-52 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 182.14 E-value: 2.31e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGgsrvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASL 84
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIG----TMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 85 HIREIFARYTSLIEPLSLDEAYLDVTDSVH-CHGSATL--MAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSAYIErFEGTKTAedVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQ 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 162 YVI---TPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDV--QRSDLAMLLK----RF---GKFGRVLWE---RS 226
Cdd:PTZ00205 292 HDLnlhTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIynRRVELCYILHnnlfRFllgASIGIMQWPdaaTA 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 227 QGIDDRDVNSERLRKSVGVERTL-----SEDIHDWSEcecIITEQLYPELErrlskvKPDLLIARQGIKLKFNDFQQttQ 301
Cdd:PTZ00205 372 ANTENCEGATGGQRKAISSERSFttprtKEGLQEMVD---TVFNGAYEEMR------KSELMCRQISLTIRWASYRY--Q 440
|
330 340
....*....|....*....|..
gi 695700134 302 EHVWPRLNKDDLIATAKKAWEE 323
Cdd:PTZ00205 441 QYTKSLIQYSDDSATLRRAVDG 462
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
4-217 |
5.68e-52 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 175.75 E-value: 5.68e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 4 IIHVDMDCFFAAVEMRDNPALRDIPIAI---GGSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYK 80
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNG 160
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 695700134 161 QYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGK 217
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGE 219
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
1-342 |
2.65e-51 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 173.67 E-value: 2.65e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 1 MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGS---RVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFE 77
Cdd:PRK03352 4 PRWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNgdpTEPRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 78 AYKEASLHIREIFARYTSLIEPLSLDEAYLDVTDsvhchGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNK 157
Cdd:PRK03352 84 AYDAASEEVMATLRDLGVPVEVWGWDEAFLGVDT-----DDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 158 PNGQYVITPEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFG-KFGRVLWERSQGIDDRDVNS 236
Cdd:PRK03352 159 PAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 237 E-RLRKSVGVERTLSEDIHDWSECECIITeqlypELERRLSK--VKPDLLIARQGIKLKFNDFqqTTQEHVW----PRLN 309
Cdd:PRK03352 239 EpWVPRSRSREVTFPQDLTDRAEVESAVR-----ELARRVLDevVAEGRPVTRVAVKVRTATF--YTRTKIRklpePTTD 311
|
330 340 350
....*....|....*....|....*....|...
gi 695700134 310 KDDLIATAKKAWEERRGGRGVRLVGLHVTLLDP 342
Cdd:PRK03352 312 PDVIEAAALDVLDRFELDRPVRLLGVRLELAMP 344
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
5-310 |
2.71e-49 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 169.57 E-value: 2.71e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 5 IHVDMDCFFAAVEMRDNPALRDIPIAIGgsrvQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGR-FEAYKEAS 83
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQ----QKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEdLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 84 LHIREIFARYT--SLIEPLSLDEAYLDVTDSVHCHGSAtlMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKPNGQ 161
Cdd:cd01703 77 KKVYRLLRSYSwnDRVERLGFDENFMDVTEMRLLVASH--IAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 162 YVITP---EEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQ-------------RSDLAMLL--KRFGK-FGRVL 222
Cdd:cd01703 155 TTLLPpscADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQefsnrnrqtvgaaPSLLELLLmvKEFGEgIGQRI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 223 WERSQGIDDRDVNSER-LRKSVGVERTlsedihdWSECECIITEQLYPELERRLS----KVKPDLLIA-----RQGIKLK 292
Cdd:cd01703 235 WKLLFGRDTSPVKPASdFPQQISIEDS-------YKKCSLEEIREARNKIEELLAslleRMKQDLQEVkagdgRRPHTLR 307
|
330
....*....|....*...
gi 695700134 293 FNDFQQTTQEHVWPRLNK 310
Cdd:cd01703 308 LTLRRYTSTKKHYNRESK 325
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
7-265 |
4.28e-41 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 146.92 E-value: 4.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 7 VDMDCFFAAVEMRDNPALRDIPIAIGgSRVQRGVIStANYPARKFGVRSAMPTAMALKLCP--HLTLLPGRFEAYKEASL 84
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVL-SNNDGCVIA-RSPEAKALGIKMGSPYFKVPDLLErhGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 85 HIREIFARYTSLIEPLSLDEAYLDVTDSVHChGSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDL----NKPNG 160
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRF-GDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakkkNPYGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 161 QYVITPEEVP-AFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDV-NSER 238
Cdd:cd01700 160 VVDLTDEEVRdKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLeEYPP 239
|
250 260
....*....|....*....|....*..
gi 695700134 239 LRKSVGVERTLSEDIHDWSECECIITE 265
Cdd:cd01700 240 PKKSIGSSRSFGRDVTDLDELKQALAE 266
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-337 |
3.48e-26 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 106.70 E-value: 3.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 19 RDNPALRDIPIAIGgSRVQRGVISTANYPARKFGVRSAMPTAMALKLCPHLTLLPGRFEAYKEASLHIREIFARYTSLIE 98
Cdd:cd03468 15 RNRPADDEAPLAVV-ERKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 99 PLSLDEAYLDVTDSVHCHGSATLMAQEIRQTiFNELNLTASAGVAPVKFLAKIASDLNKPNGQYVITPEEVPAFLKTLPL 178
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLFGGEDALAASLRAA-LATLGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALVLLAPLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 179 GKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGKFGRVLWERSQGIDDRDVNSERLRKSVG--VERTLSEDIHDW 256
Cdd:cd03468 173 VAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLFSPPPPAFDfrLELQLEEPIARG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 257 SEcecIITEQLYPELERRLSkvKPDLLIARQGIKLKFNDFQQTTQEHVWPRLNkDDLIATAK------KAWEERRGGRGV 330
Cdd:cd03468 253 LL---FPLRRLLEQLCAFLA--LRGLGARRLSLTLFREDGRVTRVLVGLARPS-RDDLPLLRllrerlERLALPRGIAPV 326
|
....*..
gi 695700134 331 RLVGLHV 337
Cdd:cd03468 327 RLLALTA 333
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
6-226 |
5.39e-15 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 75.57 E-value: 5.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 6 HVDMDCFFAAVEMRDNPALRDIPIAIGGSrvQRGVISTANYPARKFGVRSAMP--TAMALKLCPHLTLLPGRFEAYKEAS 83
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSN--NDGCVIARSAEAKALGIKMGDPwfKQKDLFRRCGVVCFSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 84 LHIREIFARYTSLIEPLSLDEAYLDVTDSVHCHgSATLMAQEIRQTIFNELNLTASAGVAPVKFLAKIASDLNKP----- 158
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCR-DLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqt 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695700134 159 NGQYVIT-PEEVPAFLKTLPLGKIPGVGKVSAAKLENMGLRTCEDVQRSDLAMLLKRFGkfgrVLWERS 226
Cdd:PRK03609 161 GGVVDLSnLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFN----VVLERT 225
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
240-343 |
2.37e-13 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 65.27 E-value: 2.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695700134 240 RKSVGVERTLSEDIHDWSECECIITEqLYPELERRLSKVKpdlLIARQ-GIKLKFNDFQQTTQEHVWPRL--NKDDLIAT 316
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLE-LAEELAERLRRQG---LVARTvTVKIRYSDFRTITRSVTLPSPtdDTDEIYRA 76
|
90 100
....*....|....*....|....*..
gi 695700134 317 AKKAWEERRGGRGVRLVGLHVTLLDPQ 343
Cdd:pfam11799 77 ALRLLRRLYRGRPVRLLGVSLSNLVPE 103
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
166-197 |
6.78e-08 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 47.78 E-value: 6.78e-08
10 20 30
....*....|....*....|....*....|..
gi 695700134 166 PEEVPAFLKTLPLGKIPGVGKVSAAKLENMGL 197
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
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