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Conserved domains on  [gi|695654016|ref|WP_032620695|]
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MULTISPECIES: As(III)-sensing metalloregulatory transcriptional repressor ArsR [Enterobacter cloacae complex]

Protein Classification

transcriptional regulator( domain architecture ID 10793347)

winged-helix type HTH-containing transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-116 6.01e-75

DNA-binding transcriptional repressor ArsR; Provisional


:

Pssm-ID: 236654  Cd Length: 117  Bit Score: 217.38  E-value: 6.01e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695654016   1 MTLTSLMLFKTLSDETRLGIVLLLREMGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPHIPSWA 80
Cdd:PRK10141   2 SFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695654016  81 AQVIEQAWLSQQDDVQAIARRLASANCSGSGKAVCI 116
Cdd:PRK10141  82 AKIIEQAWLCEQEDVQAIVRNLARQNCSGDSKNICS 117
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-116 6.01e-75

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 217.38  E-value: 6.01e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695654016   1 MTLTSLMLFKTLSDETRLGIVLLLREMGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPHIPSWA 80
Cdd:PRK10141   2 SFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695654016  81 AQVIEQAWLSQQDDVQAIARRLASANCSGSGKAVCI 116
Cdd:PRK10141  82 AKIIEQAWLCEQEDVQAIVRNLARQNCSGDSKNICS 117
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-75 1.22e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 96.38  E-value: 1.22e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695654016   8 LFKTLSDETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPH 75
Cdd:NF033788   4 LFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADE 70
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-86 8.71e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 92.26  E-value: 8.71e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695654016   8 LFKTLSDETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPHIPSWAAQVIEQ 86
Cdd:COG0640   13 LFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLLE 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-74 2.26e-19

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 75.41  E-value: 2.26e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695654016   9 FKTLSDETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSP 74
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-84 4.39e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.86  E-value: 4.39e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695654016    20 IVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSP-HIPSWAAQVI 84
Cdd:smart00418   2 ILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDeKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 14-59 2.13e-14

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 62.08  E-value: 2.13e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 695654016   14 DETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLL 59
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-116 6.01e-75

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 217.38  E-value: 6.01e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695654016   1 MTLTSLMLFKTLSDETRLGIVLLLREMGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPHIPSWA 80
Cdd:PRK10141   2 SFLLPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWA 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695654016  81 AQVIEQAWLSQQDDVQAIARRLASANCSGSGKAVCI 116
Cdd:PRK10141  82 AKIIEQAWLCEQEDVQAIVRNLARQNCSGDSKNICS 117
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 8-75 1.22e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 96.38  E-value: 1.22e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695654016   8 LFKTLSDETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPH 75
Cdd:NF033788   4 LFKALADPTRLRILELLAE-GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADE 70
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-86 8.71e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 92.26  E-value: 8.71e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695654016   8 LFKTLSDETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSPHIPSWAAQVIEQ 86
Cdd:COG0640   13 LFKALADPTRLRILRLLAE-GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWLLE 90
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-74 2.26e-19

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 75.41  E-value: 2.26e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695654016   9 FKTLSDETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSP 74
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
20-84 4.39e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.86  E-value: 4.39e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695654016    20 IVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSP-HIPSWAAQVI 84
Cdd:smart00418   2 ILKLLAE-GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDeKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 14-59 2.13e-14

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 62.08  E-value: 2.13e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 695654016   14 DETRLGIVLLLREmGELCVCDLCTALEQPQPKISRHLAMLRESGLL 59
Cdd:pfam01022   1 DPTRLKILKLLAE-GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 6-66 1.49e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.53  E-value: 1.49e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695654016    6 LMLFKTLSDETRLGIVLLLREMGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGK 66
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
7-74 1.07e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 44.48  E-value: 1.07e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695654016   7 MLFKTLSDETRLGIVLLLREMGELCVCDLCTALEQPQPKISRHLAMLRESGLLLDRKQGKWVHYRLSP 74
Cdd:COG3398   89 KILAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
22-103 2.54e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 35.95  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695654016  22 LLLREMGELCVCDLCTALEQPQPKISRHLAMLRESGLLL-DRKQGkwvHYRLSPHIPSWAAQVIEQAWLSQQddVQAIAR 100
Cdd:COG1414   17 ALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVErDPEGG---RYRLGPRLLELGSAALRRLDLRRL--ARPVLE 91


                 ...
gi 695654016 101 RLA 103
Cdd:COG1414   92 ELA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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