|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
41-1649 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1460.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 41 PGATAKPDRAQLAALAEKSQGKALTLLDASEVQLDGAATLVLTFSVPLQPDQDFSRSVHLVDKKSGKVDGAWELAPNLKE 120
Cdd:COG2373 20 ALALLALLALLLGAALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLALSLLSAAALLLLALL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 121 LRLRHLEPKRELIVSVDPTLTALNKATLDKPFEKTLTTRDIAPSVGFASRGSLLPGNVVAGLPvmALNVDNVDVNFFRIK 200
Cdd:COG2373 100 AALALAVRAAALAASSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAAL--AALLAAAAAALLALA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 201 PESLSAFVSQWEYRNSLSNWESDELLKMADLVYsgRFDLNPARNTREKLLLPLSDIKPLQQPGVYVAVMNPAGRYSY--- 277
Cdd:COG2373 178 ALAAELAALLALALVLAAALLAPAALSEVALLL--EPDLKGKLNKRVTTALPLSELLALLKPGVYLVVARFPGDYSYnge 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 278 SNAATLFTLSDIGVSAHRYHNRLDVFTQSLENGAAQSGIEVQLLNAKGQTLAEAKSDSQGHVTL------QTDKEAALLL 351
Cdd:COG2373 256 SRATQWFLVSDLGLTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFpagdrgEGGRAPALLV 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 352 ARKEGQTTLLDLK-LPALDLAEFSIAG-APGFSKQFFMFGPRDLYRPGETVILNALLRDSDGKPLAEQPVKLEVVQPDGQ 429
Cdd:COG2373 336 ARKGGDFAFLDLDdGPALDLSDFDVGGrAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLTLELTDPDGK 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 430 VIRSVMSKP-VNGLYQFTYPLDSGAATGMWHIRASAGDNQP-REWDFHVEDFMPERMALNLTPQAAPVAPDADVTFGVSG 507
Cdd:COG2373 416 EVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLELYVDPKPAlGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDA 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 508 AYLYGAPASGNQLQGKLFLRPLRDAVAALPGFQFGDIVEENLSRSLDEVQLTLDEKGHGEVT-TSSQWQDSHSPLQVVLQ 586
Cdd:COG2373 496 RYLFGAPAAGLKVEGEVTLRPARTAFPGYPGYRFGDPDEEFEPEELDLGEGTLDADGKASLSlPLPDAPDAPGPLRATVE 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 587 ASLLESGGRPVTRTVKQPIWPAEALPGIR-PQFTLKDvydyrtdttvkqpvvdENSNAAFDIVYADVKGEKKAISGLQVR 665
Cdd:COG2373 576 ASVFESGGRPVTRSATVPVHPADFYVGIRlPLFDGDP----------------EGAPATFEVVAVDPDGKPVAGKGLKVE 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 666 LIRERRDYYWNWSDSEGWQSQFDQKDLQEGEESLDLQAGQIGKVSF-PVEWGSYRLEVKGPDD-VVSSVRFWAGyswqdN 743
Cdd:COG2373 640 LYREEWRYVWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSLtPVEWGRYRLEVKDPDGgLATSVRFYAG-----G 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 744 SEGAGAARPDRVTMKLDKPSYKPGDTIRLHIAAPAAGKGYAMVESsEGPLWWQEIDVPAEGMDLSIPVDKTWnRHDLYLS 823
Cdd:COG2373 715 NASWGAERPDRLELSLDKESYKPGETAKLLIQSPFAGRALVTVER-DGVLETQWVDVKGGGTTVEIPVTEDW-APNAYVS 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 824 TLVVRPGDKSRSATPKRAVGLLHLPLGDENRRLTLALEAPDKMRPNQPLTVKVKASvkeGEAPKRVNVLLSAVDSGVLNI 903
Cdd:COG2373 793 ATLVRPGDSTANDMPARAYGVAPLPVDPPARRLKVELTAPEKLRPGETLTVTVKVK---GAAGKAAEVTLAAVDEGILNL 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 904 TDYATPDPWNAFFGQKRYGADIYDIYGQVIEG-QGRVASLRFGGDGdELKRGG--KPPVNHVTIVAQQAQPVVLNDQGEG 980
Cdd:COG2373 870 TGYKTPDPLDFFYGKRALGVETRDLYGRLIGAfGGAAGALRSGGDG-ALGRGGnpKPPRKRFKPVALFSGPVKTDADGKA 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 981 TVTLPIGDFNGELRVMAQAWTADDFGSSEDKVVVAAPVIAELNTPRFLASGDTTRLALDLSNLTDKPQTLQVHLTASGLV 1060
Cdd:COG2373 949 TVSFDLPDFNGTLRVMAVAWSDDRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL 1028
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1061 TLTDGQLPPVQLAPGARSTLFIPVSALAGfGDGQVNATISGlslPGETFAplqKQWKIGVRPAYPAQTVNSGAVLQPGES 1140
Cdd:COG2373 1029 TLEGEATQTVTLAAGGRATVRFPLKAPDA-GDAKVTVTATG---GGESDA---REVELPVRPANPLVTRATSGVLAPGES 1101
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1141 WQPPAAQSQGFAPQTLQGQLLLSGKPPLNLARYIRELKAYPYGCLEQTASGLFPSLYTSAAqLKALGISGDSDEKRRAAI 1220
Cdd:COG2373 1102 WTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDL-AEALGLKGDKDAELRARI 1180
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1221 DVGISRLLQMQLENGGFALWDREGPEEYWLTAYAMDFLVRASEQGYSVPVNAINKGNERLLRYLQEPGLMtvrysDDAQA 1300
Cdd:COG2373 1181 QAAIARLLSMQNSDGGFGLWPGGSESDPWLTAYATDFLLEAREAGYAVPDDALDRALDYLRNYLRNPWEI-----EYDDA 1255
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1301 SRFAAQAYAALVLARQQKAPLGALREIWSRHDQARSGLPLLQLGIALKTMGDAPRGDAALKLAVATPRQDE--NRWLGDY 1378
Cdd:COG2373 1256 YRLAVRAYALYVLARAGKADLGDLRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGarDYWYGDY 1335
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1379 GSPLRDNALKLALLEENKLLPEVQNQLLSTLSEEAYGQRWLSTQETNALFLAGRTLADLPGS---WQAQTSL--QAEPLA 1453
Cdd:COG2373 1336 GSPLRDQALALALLAELGPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAYARAAGAspdFTATLTLdgKTLPLT 1415
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1454 GDKAQTR-NLDGDRLAA--LQVSNTGSQPLWLRLDSSGYPQ-SAPQPGGNVLGIERTIFDTQGQQKSLSSLRSGELVLVK 1529
Cdd:COG2373 1416 GRGPLARvTLPAAELLAgpLTITNTGDGPLYYTLTLSGYPAeGPPPAASNGLEIERRYYDLDGKPIDPASLKQGDLVVVR 1495
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1530 LEVTAKRN-VPDALVVDLLPAGLELENQNLANSSASLQEngdavqnllnQMQQADIQHIEFRDDRFVAAFAVNEGQPVTL 1608
Cdd:COG2373 1496 LTVTAPSGrVENVAVVDPLPAGFEIENPRLATSGDLGDW----------LGDSWQPDHQEFRDDRVVAAFDLDPAGTYTF 1565
|
1610 1620 1630 1640
....*....|....*....|....*....|....*....|.
gi 694072639 1609 VYLARAVTPGTYQVPQPQVESMYAPQWRATGAAsGPLTVTP 1649
Cdd:COG2373 1566 AYLVRAVTPGTFVLPPAQAEDMYRPEVRARSAG-GRVTVVA 1605
|
|
| bMG1 |
pfam17970 |
Bacterial Alpha-2-macroglobulin MG1 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
56-160 |
5.33e-62 |
|
Bacterial Alpha-2-macroglobulin MG1 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG1 domain which is the farthest from the body of the structure. It is normally anchored to the inner membrane in vivo and connected to MG2 by a flexible linker.
Pssm-ID: 465597 Cd Length: 105 Bit Score: 206.39 E-value: 5.33e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 56 AEKSQGKALTLLDASEVQLDGAATLVLTFSVPLQPDQDFSRSVHLVDKKSGKVDGAWELAPNLKELRLRHLEPKRELIVS 135
Cdd:pfam17970 1 AKRYAGKPLTVLDASEVQLDGASTLVVTFSVPLDPEQDFAERLHLVDKKSGKVDGAWELSDNLMELRLRHLEPKRKLVLT 80
|
90 100
....*....|....*....|....*
gi 694072639 136 VDPTLTALNKATLDKPFEKTLTTRD 160
Cdd:pfam17970 81 VDAGLRALNGATLAKEYEKTLTTRD 105
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1170-1434 |
5.94e-49 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 176.04 E-value: 5.94e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1170 LARYIRELKAYPYGCLEQTASGLFPSLYTSAAQLKALGISGDSDEKRRAAIDVGISRLLQMQLENGGFALWDREGPEEYW 1249
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1250 LTAYAMDFLVRASEQGYsVPVNAINKGNERLLRYLQEPGL------MTVRYSDDAQASRFAAQAYAALVLARQQK----A 1319
Cdd:cd02891 81 LTAYVVKFLSQARKYID-VDENVLARALGWLVPQQKEDGSfrelgpVIHREMKGGVDDSVSLTAYVLIALAEAGKacdaS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1320 PLGALREIWSRHDQARSGLPLLQLGIALKTMGDAPRGDAAL-KLAVATPRQD-----ENRWLGDYGSPLRDNALKLALLE 1393
Cdd:cd02891 160 IEKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALkKLLEAAREKGgtahwSLSWPGDYGSSLRVEATAYALLA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 694072639 1394 ENKL-LPEVQNQLLSTLSE-EAYGQRWLSTQETNALFLAGRTL 1434
Cdd:cd02891 240 LLKLgDLEEAGPIAKWLAQqRNSGGGFLSTQDTVVALQALAAY 282
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
41-1649 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1460.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 41 PGATAKPDRAQLAALAEKSQGKALTLLDASEVQLDGAATLVLTFSVPLQPDQDFSRSVHLVDKKSGKVDGAWELAPNLKE 120
Cdd:COG2373 20 ALALLALLALLLGAALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLALSLLSAAALLLLALL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 121 LRLRHLEPKRELIVSVDPTLTALNKATLDKPFEKTLTTRDIAPSVGFASRGSLLPGNVVAGLPvmALNVDNVDVNFFRIK 200
Cdd:COG2373 100 AALALAVRAAALAASSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAAL--AALLAAAAAALLALA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 201 PESLSAFVSQWEYRNSLSNWESDELLKMADLVYsgRFDLNPARNTREKLLLPLSDIKPLQQPGVYVAVMNPAGRYSY--- 277
Cdd:COG2373 178 ALAAELAALLALALVLAAALLAPAALSEVALLL--EPDLKGKLNKRVTTALPLSELLALLKPGVYLVVARFPGDYSYnge 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 278 SNAATLFTLSDIGVSAHRYHNRLDVFTQSLENGAAQSGIEVQLLNAKGQTLAEAKSDSQGHVTL------QTDKEAALLL 351
Cdd:COG2373 256 SRATQWFLVSDLGLTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFpagdrgEGGRAPALLV 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 352 ARKEGQTTLLDLK-LPALDLAEFSIAG-APGFSKQFFMFGPRDLYRPGETVILNALLRDSDGKPLAEQPVKLEVVQPDGQ 429
Cdd:COG2373 336 ARKGGDFAFLDLDdGPALDLSDFDVGGrAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGLPLTLELTDPDGK 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 430 VIRSVMSKP-VNGLYQFTYPLDSGAATGMWHIRASAGDNQP-REWDFHVEDFMPERMALNLTPQAAPVAPDADVTFGVSG 507
Cdd:COG2373 416 EVRRQTLTLnEFGGYSFSFPLPEDAPTGTWRLELYVDPKPAlGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDA 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 508 AYLYGAPASGNQLQGKLFLRPLRDAVAALPGFQFGDIVEENLSRSLDEVQLTLDEKGHGEVT-TSSQWQDSHSPLQVVLQ 586
Cdd:COG2373 496 RYLFGAPAAGLKVEGEVTLRPARTAFPGYPGYRFGDPDEEFEPEELDLGEGTLDADGKASLSlPLPDAPDAPGPLRATVE 575
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 587 ASLLESGGRPVTRTVKQPIWPAEALPGIR-PQFTLKDvydyrtdttvkqpvvdENSNAAFDIVYADVKGEKKAISGLQVR 665
Cdd:COG2373 576 ASVFESGGRPVTRSATVPVHPADFYVGIRlPLFDGDP----------------EGAPATFEVVAVDPDGKPVAGKGLKVE 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 666 LIRERRDYYWNWSDSEGWQSQFDQKDLQEGEESLDLQAGQIGKVSF-PVEWGSYRLEVKGPDD-VVSSVRFWAGyswqdN 743
Cdd:COG2373 640 LYREEWRYVWYKSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSLtPVEWGRYRLEVKDPDGgLATSVRFYAG-----G 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 744 SEGAGAARPDRVTMKLDKPSYKPGDTIRLHIAAPAAGKGYAMVESsEGPLWWQEIDVPAEGMDLSIPVDKTWnRHDLYLS 823
Cdd:COG2373 715 NASWGAERPDRLELSLDKESYKPGETAKLLIQSPFAGRALVTVER-DGVLETQWVDVKGGGTTVEIPVTEDW-APNAYVS 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 824 TLVVRPGDKSRSATPKRAVGLLHLPLGDENRRLTLALEAPDKMRPNQPLTVKVKASvkeGEAPKRVNVLLSAVDSGVLNI 903
Cdd:COG2373 793 ATLVRPGDSTANDMPARAYGVAPLPVDPPARRLKVELTAPEKLRPGETLTVTVKVK---GAAGKAAEVTLAAVDEGILNL 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 904 TDYATPDPWNAFFGQKRYGADIYDIYGQVIEG-QGRVASLRFGGDGdELKRGG--KPPVNHVTIVAQQAQPVVLNDQGEG 980
Cdd:COG2373 870 TGYKTPDPLDFFYGKRALGVETRDLYGRLIGAfGGAAGALRSGGDG-ALGRGGnpKPPRKRFKPVALFSGPVKTDADGKA 948
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 981 TVTLPIGDFNGELRVMAQAWTADDFGSSEDKVVVAAPVIAELNTPRFLASGDTTRLALDLSNLTDKPQTLQVHLTASGLV 1060
Cdd:COG2373 949 TVSFDLPDFNGTLRVMAVAWSDDRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL 1028
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1061 TLTDGQLPPVQLAPGARSTLFIPVSALAGfGDGQVNATISGlslPGETFAplqKQWKIGVRPAYPAQTVNSGAVLQPGES 1140
Cdd:COG2373 1029 TLEGEATQTVTLAAGGRATVRFPLKAPDA-GDAKVTVTATG---GGESDA---REVELPVRPANPLVTRATSGVLAPGES 1101
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1141 WQPPAAQSQGFAPQTLQGQLLLSGKPPLNLARYIRELKAYPYGCLEQTASGLFPSLYTSAAqLKALGISGDSDEKRRAAI 1220
Cdd:COG2373 1102 WTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDL-AEALGLKGDKDAELRARI 1180
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1221 DVGISRLLQMQLENGGFALWDREGPEEYWLTAYAMDFLVRASEQGYSVPVNAINKGNERLLRYLQEPGLMtvrysDDAQA 1300
Cdd:COG2373 1181 QAAIARLLSMQNSDGGFGLWPGGSESDPWLTAYATDFLLEAREAGYAVPDDALDRALDYLRNYLRNPWEI-----EYDDA 1255
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1301 SRFAAQAYAALVLARQQKAPLGALREIWSRHDQARSGLPLLQLGIALKTMGDAPRGDAALKLAVATPRQDE--NRWLGDY 1378
Cdd:COG2373 1256 YRLAVRAYALYVLARAGKADLGDLRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGarDYWYGDY 1335
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1379 GSPLRDNALKLALLEENKLLPEVQNQLLSTLSEEAYGQRWLSTQETNALFLAGRTLADLPGS---WQAQTSL--QAEPLA 1453
Cdd:COG2373 1336 GSPLRDQALALALLAELGPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAYARAAGAspdFTATLTLdgKTLPLT 1415
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1454 GDKAQTR-NLDGDRLAA--LQVSNTGSQPLWLRLDSSGYPQ-SAPQPGGNVLGIERTIFDTQGQQKSLSSLRSGELVLVK 1529
Cdd:COG2373 1416 GRGPLARvTLPAAELLAgpLTITNTGDGPLYYTLTLSGYPAeGPPPAASNGLEIERRYYDLDGKPIDPASLKQGDLVVVR 1495
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1530 LEVTAKRN-VPDALVVDLLPAGLELENQNLANSSASLQEngdavqnllnQMQQADIQHIEFRDDRFVAAFAVNEGQPVTL 1608
Cdd:COG2373 1496 LTVTAPSGrVENVAVVDPLPAGFEIENPRLATSGDLGDW----------LGDSWQPDHQEFRDDRVVAAFDLDPAGTYTF 1565
|
1610 1620 1630 1640
....*....|....*....|....*....|....*....|.
gi 694072639 1609 VYLARAVTPGTYQVPQPQVESMYAPQWRATGAAsGPLTVTP 1649
Cdd:COG2373 1566 AYLVRAVTPGTFVLPPAQAEDMYRPEVRARSAG-GRVTVVA 1605
|
|
| bMG1 |
pfam17970 |
Bacterial Alpha-2-macroglobulin MG1 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
56-160 |
5.33e-62 |
|
Bacterial Alpha-2-macroglobulin MG1 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG1 domain which is the farthest from the body of the structure. It is normally anchored to the inner membrane in vivo and connected to MG2 by a flexible linker.
Pssm-ID: 465597 Cd Length: 105 Bit Score: 206.39 E-value: 5.33e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 56 AEKSQGKALTLLDASEVQLDGAATLVLTFSVPLQPDQDFSRSVHLVDKKSGKVDGAWELAPNLKELRLRHLEPKRELIVS 135
Cdd:pfam17970 1 AKRYAGKPLTVLDASEVQLDGASTLVVTFSVPLDPEQDFAERLHLVDKKSGKVDGAWELSDNLMELRLRHLEPKRKLVLT 80
|
90 100
....*....|....*....|....*
gi 694072639 136 VDPTLTALNKATLDKPFEKTLTTRD 160
Cdd:pfam17970 81 VDAGLRALNGATLAKEYEKTLTTRD 105
|
|
| bMG5 |
pfam17972 |
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
482-607 |
3.17e-52 |
|
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG5 domain.
Pssm-ID: 436183 Cd Length: 127 Bit Score: 179.63 E-value: 3.17e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 482 ERMALNLTPQAAPVAPDADVTFGVSGAYLYGAPASGNQLQGKLFLRPLRDAVAALPGFQFGDIVEENLSRSLDEVQLTLD 561
Cdd:pfam17972 1 ERMDLDLSLPDAPLAPGDPAELDVDARYLYGAPAAGLRLEGELTLRPARHALAGFPGYRFGRHDEELLKRTRDLPDLTTD 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 694072639 562 EKGHGEVTTS-SQWQDSHSPLQVVLQASLLESGGRPVTRTVKQPIWP 607
Cdd:pfam17972 81 AQGKATLTVPlPEWPAATRPLEARVTVSLLESGGRPVERSLTRPVWP 127
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1170-1434 |
5.94e-49 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 176.04 E-value: 5.94e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1170 LARYIRELKAYPYGCLEQTASGLFPSLYTSAAQLKALGISGDSDEKRRAAIDVGISRLLQMQLENGGFALWDREGPEEYW 1249
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1250 LTAYAMDFLVRASEQGYsVPVNAINKGNERLLRYLQEPGL------MTVRYSDDAQASRFAAQAYAALVLARQQK----A 1319
Cdd:cd02891 81 LTAYVVKFLSQARKYID-VDENVLARALGWLVPQQKEDGSfrelgpVIHREMKGGVDDSVSLTAYVLIALAEAGKacdaS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1320 PLGALREIWSRHDQARSGLPLLQLGIALKTMGDAPRGDAAL-KLAVATPRQD-----ENRWLGDYGSPLRDNALKLALLE 1393
Cdd:cd02891 160 IEKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALkKLLEAAREKGgtahwSLSWPGDYGSSLRVEATAYALLA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 694072639 1394 ENKL-LPEVQNQLLSTLSE-EAYGQRWLSTQETNALFLAGRTL 1434
Cdd:cd02891 240 LLKLgDLEEAGPIAKWLAQqRNSGGGFLSTQDTVVALQALAAY 282
|
|
| bMG6 |
pfam17962 |
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 ... |
613-738 |
1.53e-31 |
|
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 macroglobulin proteins. It adopts an Ig-like beta sandwich fold.
Pssm-ID: 436175 Cd Length: 112 Bit Score: 119.66 E-value: 1.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 613 GIRPQFTlkdvYDYrtdttvkqpvVDENSNAAFDIVYADVKGEKKAISGLQVRLIRERRDYYWnWSDSEGWQSQFDQKDL 692
Cdd:pfam17962 1 GIRPLFD----DGS----------LEEGKEAAFEVVAVDADGKPVAVQGLEWTLYREEWDYQW-YRQDGGWSYEPVTRDK 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 694072639 693 QEGEESLDLQAGQIGKVSFPVEWGSYRLEVKGPDD-VVSSVRFWAGY 738
Cdd:pfam17962 66 RVATGTVDTGADGPATISLPVDWGRYRLEVEDPGGgAATSVRFYAGW 112
|
|
| bMG10 |
pfam17973 |
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1501-1634 |
2.52e-30 |
|
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.
Pssm-ID: 465598 Cd Length: 128 Bit Score: 117.02 E-value: 2.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1501 LGIERTIFDTQGQQKSLS---SLRSGELVLVKLEVTAKRNVPDALVVDLLPAGLELENQNLANSSASLQENGDAVQnlln 1577
Cdd:pfam17973 2 LSVTRRFYVLEGSGVSASdaeTLKVGDKVRVRLTVTTDRDRDFVALEDPLPAGLEPVNPLSGYTWEGGLGYPDNTQ---- 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 694072639 1578 qmqqadIQHIEFRDDRFVAAFAVNEGQPVTLVYLARAVTPGTYQVPQPQVESMYAPQ 1634
Cdd:pfam17973 78 ------PSYREVRDDRVRFFADYLPKGTYTFEYLVRAVTPGTFTVPPATAESMYAPE 128
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
286-380 |
1.29e-23 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 96.90 E-value: 1.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 286 LSDIGVSAHRYHNRLDVFTQSLENGAAQSGIEVQLLNAKGQTLAEAKSDSQGHVTLQT------DKEAALLLARKEGQTT 359
Cdd:pfam11974 1 VSDLGLHAKQGRDGLLVWVTSLDSGKPVAGVEVRLLDCNGQVLATGTTDAQGHARFEGpltrdgGAAPALVSARKDGDFA 80
|
90 100
....*....|....*....|..
gi 694072639 360 LLDLKL-PALDLAEFSIAGAPG 380
Cdd:pfam11974 81 FLRLDWgPALDLSDFDVGGRPP 102
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
385-476 |
1.03e-22 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 93.92 E-value: 1.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 385 FFMFGPRDLYRPGETVILNALLRDSDGKPLAEQPVKLEVVQPDGQVIRS-VMSKPVNGLYQFTYPLDSGAATGMWHIRAS 463
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRlPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 694072639 464 AGDNQPR-EWDFHV 476
Cdd:pfam01835 82 DGAGGSLgSGSFRV 95
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1170-1430 |
1.89e-20 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 93.77 E-value: 1.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1170 LARYIRELKAYPYG--------CLEQTASGLFPSLYtsaaqLKALGISGDSDEKRRAAIDVGISRLLQMQLENGGFALWD 1241
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLA-----LLLLLAATGIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1242 REGPEEYWLTAYAMDFLVRASEQGYsVPVNAINKGNERLLRYLQEPG----LMTVRYSDDAQASRFAAQAYAALVLARQQ 1317
Cdd:cd00688 76 GNDYPSLWLTAYALKALLLAGDYIA-VDRIDLARALNWLLSLQNEDGgfreDGPGNHRIGGDESDVRLTAYALIALALLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1318 KAPL-----GALREIWSRHDQARSGLP--------LLQLGIALKTMGDAPRGDAALKLAVATPRQDEN-------RWLGD 1377
Cdd:cd00688 155 KLDPdplieKALDYLLSCQNYDGGFGPggeshgygTACAAAALALLGDLDSPDAKKALRWLLSRQRPDggwgegrDRTNK 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 694072639 1378 YGSPLRDNALKLALLEENKLL-PEVQNQLLSTLSE-EAYGQRWLS-------TQETNALFLA 1430
Cdd:cd00688 235 LSDSCYTEWAAYALLALGKLGdLEDAEKLVKWLLSqQNEDGGFSSkpgksydTQHTVFALLA 296
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
755-903 |
8.24e-15 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 73.15 E-value: 8.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 755 VTMKLDKPSYKPGDTIRLHIAAPAAG-----KGYAMVessegpLWWQEIDVPAEGMD---LSIPVDKTWNRHDlYLSTLV 826
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGtverdGFTYLV------LSKGQIVVVGRGGVttsFSLPVTAEMAPSA-RVVAYY 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 694072639 827 VRPGDKSrsatPKRAVGLLHLPL-GDENRRLTLALEaPDKMRPNQPLTVKVKasvkegeAPKRVNVLLSAVDSGVLNI 903
Cdd:pfam07703 74 VRVDLSK----PEVVADSVWVDVdDTCENKLKVTLS-AEKYRPGSTVELKVK-------ADPGAYVALAAVDKGVLLL 139
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
970-1054 |
2.58e-07 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 49.89 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 970 QPVVLNDQGEGTVTLPIGDFNGELRVMAQAWTADD-FGSSE-DKVVVAAPVIAELNTPRFLASGDTTRLALDLSNLTDKP 1047
Cdd:pfam00207 5 DPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTgLGVAEpPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNYLDKC 84
|
....*..
gi 694072639 1048 QTLQVHL 1054
Cdd:pfam00207 85 LKVRVRL 91
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
1169-1287 |
1.11e-04 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 46.11 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1169 NLARYIRelkaYPYGCLEQTASGLFPSLYT-----SAAQLKALGIsgdsdEKRRAA---IDVGISRLLQMQLENGGFALW 1240
Cdd:cd02896 4 GLEKLIR----LPTGCGEQTMIKLAPTVYAlryldTTNQWEKLGP-----ERRDEAlkyIRQGYQRQLSYRKPDGSYAAW 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 694072639 1241 DREGPEEyWLTAYAMDFLVRASEQgYSVPVNAINKGnerlLRYL---QEP 1287
Cdd:cd02896 75 KNRPSST-WLTAFVVKVFSLARKY-IPVDQNVICGS----VNWLisnQKP 118
|
|
| COG1470 |
COG1470 |
Uncharacterized membrane protein [Function unknown]; |
1029-1140 |
1.45e-04 |
|
Uncharacterized membrane protein [Function unknown];
Pssm-ID: 441079 [Multi-domain] Cd Length: 475 Bit Score: 46.39 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1029 ASGDTTRLALDLSNLTDKPQTlqVHLTASGL---VTLTDGQLPPVQLAPGARSTLFIPVSALAGFGDGQVNATISGLSLP 1105
Cdd:COG1470 109 APGETVTYTVTLTNTGDEPDT--VSLSAEGLpegWTVTFTPDTSVSLAPGESKTVTLEVTPPANAEPGTYPVTVTATSGE 186
|
90 100 110
....*....|....*....|....*....|....*
gi 694072639 1106 GETFAPLQKQWKIGVRPAYPAQTVNSGAVLQPGES 1140
Cdd:COG1470 187 DSSSASLTLTLTVTGSYELELSSTPTGRTVTPGES 221
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1181-1273 |
3.20e-04 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 44.60 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 694072639 1181 PYGCLEQTASGLFPSLYTsaaqLKALGISGD-SDEKRRAAID---VGISRLLQMQLENGGFALWdREGPEEYWLTAYAMD 1256
Cdd:pfam07678 26 PYGCGEQNMVLFAPNVYV----LRYLDKTNQlTKLIKSKAIDyleQGYQRQLSYKHPDGSYSAF-GHSPGSTWLTAFVLK 100
|
90
....*....|....*..
gi 694072639 1257 FLVRASEQgYSVPVNAI 1273
Cdd:pfam07678 101 VFAQARKF-IFIDPEEI 116
|
|
| |
