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Conserved domains on  [gi|693209736|ref|WP_032328773|]
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D-alanine--D-alanine ligase [Escherichia coli]

Protein Classification

D-alanine--D-alanine ligase family protein( domain architecture ID 11479728)

D-alanine--D-alanine ligase family protein similar to D-alanine--D-alanine ligase that catalyzes the synthesis of D-alanyl-D-alanine, an essential component of bacterial peptidoglycan, and is involved in cell wall formation

EC:  6.3.2.-
Gene Ontology:  GO:0009252|GO:0008716|GO:0046872|GO:0005524
SCOP:  4002041|4003870

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-352 0e+00

D-alanine--D-alanine ligase;


:

Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 544.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   1 MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSDASNYLLNTDdpahIALRPSATSLAQVP 80
Cdd:PRK01966   1 MMKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNMELADD----DNDKEDLSLLILPS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  81 GKHEHqlidaqngqplptVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFIT 160
Cdd:PRK01966  77 GGSEE-------------VDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVV 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 161 LTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDnPQ 240
Cdd:PRK01966 144 LTRGDWEEASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGND-PK 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 241 ASTCGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLP 320
Cdd:PRK01966 223 ASVPGEIVKPDDFYDYEAKYLD-GSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMP 301

                        330       340       350
                 ....*....|....*....|....*....|..
gi 693209736 321 GFTNISMYPKLWQASGLGYTDLITRLIELALE 352
Cdd:PRK01966 302 GFTPISMYPKLWEASGLSYPELIDRLIELALE 333
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-352 0e+00

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 544.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   1 MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSDASNYLLNTDdpahIALRPSATSLAQVP 80
Cdd:PRK01966   1 MMKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNMELADD----DNDKEDLSLLILPS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  81 GKHEHqlidaqngqplptVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFIT 160
Cdd:PRK01966  77 GGSEE-------------VDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVV 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 161 LTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDnPQ 240
Cdd:PRK01966 144 LTRGDWEEASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGND-PK 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 241 ASTCGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLP 320
Cdd:PRK01966 223 ASVPGEIVKPDDFYDYEAKYLD-GSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMP 301

                        330       340       350
                 ....*....|....*....|....*....|..
gi 693209736 321 GFTNISMYPKLWQASGLGYTDLITRLIELALE 352
Cdd:PRK01966 302 GFTPISMYPKLWEASGLSYPELIDRLIELALE 333
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 5-350 1.30e-156

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 442.11  E-value: 1.30e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736    5 RVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWhvsdasnyllNTDDPAHIALRpsatslaqvpgkhe 84
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGSW----------TYKDLPQLILE-------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   85 hqlidaqNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTRa 164
Cdd:TIGR01205  57 -------LGALLEGIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQ- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  165 NRHNISFAE---VESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDN--P 239
Cdd:TIGR01205 129 NRASADELEceqVAEPLGFPVIVKPAREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEalP 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  240 QASTCGEIVltsDFYAYDTKYIDEDgAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTL 319
Cdd:TIGR01205 209 IIEIVPEIE---GFYDYEAKYLDGS-TEYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTI 284

                         330       340       350
                  ....*....|....*....|....*....|.
gi 693209736  320 PGFTNISMYPKLWQASGLGYTDLITRLIELA 350
Cdd:TIGR01205 285 PGMTAISLFPKAAAAAGIEFSQLVERILELA 315
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 4-351 1.90e-155

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 438.77  E-value: 1.90e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   4 LRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQgqwhvsdasnyllntDDPAHIALRPsatslaqvpgkh 83
Cdd:COG1181    1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVE---------------DLPAALKELK------------ 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  84 ehqlidaqngqplptVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTR 163
Cdd:COG1181   54 ---------------PDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRR 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 164 ANRHNIsfAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDNPQAST 243
Cdd:COG1181  119 GELADL--EAIEEELGLPLFVKPAREGSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGPRALP 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 244 CGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLPGFT 323
Cdd:COG1181  197 PIEIVPENGFYDYEAKYTD-GGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMT 275

                        330       340
                 ....*....|....*....|....*...
gi 693209736 324 NISMYPKLWQASGLGYTDLITRLIELAL 351
Cdd:COG1181  276 PTSLLPKAAAAAGISYEELIERIIELAL 303
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 147-348 2.34e-110

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 320.80  E-value: 2.34e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  147 LLRDAGLNIAPFITLTRANRHNI---SFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQG 223
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADWKLNpkeWCAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  224 IKGREIECAVLGNDNPQASTCGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDV 303
Cdd:pfam07478  81 IEGREIECAVLGNEDPEVSPVGEIVPSGGFYDYEAKYID-DSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 693209736  304 FLTPENEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIE 348
Cdd:pfam07478 160 FLTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-352 0e+00

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 544.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   1 MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSDASNYLLNTDdpahIALRPSATSLAQVP 80
Cdd:PRK01966   1 MMKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGITKDGRWYLIDADNMELADD----DNDKEDLSLLILPS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  81 GKHEHqlidaqngqplptVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFIT 160
Cdd:PRK01966  77 GGSEE-------------VDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVV 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 161 LTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDnPQ 240
Cdd:PRK01966 144 LTRGDWEEASLAEIEAKLGLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGND-PK 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 241 ASTCGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLP 320
Cdd:PRK01966 223 ASVPGEIVKPDDFYDYEAKYLD-GSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMP 301

                        330       340       350
                 ....*....|....*....|....*....|..
gi 693209736 321 GFTNISMYPKLWQASGLGYTDLITRLIELALE 352
Cdd:PRK01966 302 GFTPISMYPKLWEASGLSYPELIDRLIELALE 333
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 5-350 1.30e-156

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 442.11  E-value: 1.30e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736    5 RVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWhvsdasnyllNTDDPAHIALRpsatslaqvpgkhe 84
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGSW----------TYKDLPQLILE-------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   85 hqlidaqNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTRa 164
Cdd:TIGR01205  57 -------LGALLEGIDVVFPVLHGRYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQ- 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  165 NRHNISFAE---VESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDN--P 239
Cdd:TIGR01205 129 NRASADELEceqVAEPLGFPVIVKPAREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEalP 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  240 QASTCGEIVltsDFYAYDTKYIDEDgAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTL 319
Cdd:TIGR01205 209 IIEIVPEIE---GFYDYEAKYLDGS-TEYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTI 284

                         330       340       350
                  ....*....|....*....|....*....|.
gi 693209736  320 PGFTNISMYPKLWQASGLGYTDLITRLIELA 350
Cdd:TIGR01205 285 PGMTAISLFPKAAAAAGIEFSQLVERILELA 315
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 4-351 1.90e-155

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 438.77  E-value: 1.90e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   4 LRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQgqwhvsdasnyllntDDPAHIALRPsatslaqvpgkh 83
Cdd:COG1181    1 MRVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVE---------------DLPAALKELK------------ 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  84 ehqlidaqngqplptVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTR 163
Cdd:COG1181   54 ---------------PDVVFPALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRR 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 164 ANRHNIsfAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDNPQAST 243
Cdd:COG1181  119 GELADL--EAIEEELGLPLFVKPAREGSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGPRALP 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 244 CGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINTLPGFT 323
Cdd:COG1181  197 PIEIVPENGFYDYEAKYTD-GGTEYICPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMT 275

                        330       340
                 ....*....|....*....|....*...
gi 693209736 324 NISMYPKLWQASGLGYTDLITRLIELAL 351
Cdd:COG1181  276 PTSLLPKAAAAAGISYEELIERIIELAL 303
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 147-348 2.34e-110

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 320.80  E-value: 2.34e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  147 LLRDAGLNIAPFITLTRANRHNI---SFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQG 223
Cdd:pfam07478   1 LLKAAGLPVVPFVTFTRADWKLNpkeWCAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  224 IKGREIECAVLGNDNPQASTCGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDV 303
Cdd:pfam07478  81 IEGREIECAVLGNEDPEVSPVGEIVPSGGFYDYEAKYID-DSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 693209736  304 FLTPENEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIE 348
Cdd:pfam07478 160 FLTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 1-353 4.19e-106

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 313.59  E-value: 4.19e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   1 MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVllGIDKQgqwhvsdasnyllntDDPAHI--ALRPsatslaq 78
Cdd:PRK01372   2 KMFGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYDAH--PIDPG---------------EDIAAQlkELGF------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  79 vpgkhehqlidaqngqplptvDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPF 158
Cdd:PRK01372  58 ---------------------DRVFNALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPW 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 159 ITLTRANrhniSFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNdn 238
Cdd:PRK01372 117 IVLTREE----DLLAAIDKLGLPLVVKPAREGSSVGVSKVKEEDELQAALELAFKYDDEVLVEKYIKGRELTVAVLGG-- 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 239 pQASTCGEIVLTSDFYAYDTKYIDeDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINT 318
Cdd:PRK01372 191 -KALPVIEIVPAGEFYDYEAKYLA-GGTQYICPAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKPYLLEVNT 268

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 693209736 319 LPGFTNISMYPKLWQASGLGYTDLITRLIELALER 353
Cdd:PRK01372 269 QPGMTSHSLVPMAARAAGISFSELVDRILEDALCD 303
PRK14570 PRK14570
D-alanyl-alanine synthetase A; Provisional
 8-355 1.78e-67

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173034 [Multi-domain]  Cd Length: 364  Bit Score: 216.62  E-value: 1.78e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   8 IVFGGKSAEHEVSLQSAKNIVDAI-DKSRFDVVLLGIDK-QGQWHVSDAsnyllnTDDPAHIALRPSATSLAQVPGKHEH 85
Cdd:PRK14570   7 LIFGGVSFEHEISLRSAYGIYSALlKLDKYNIYSVFIDKcTGIWYLLDS------VPDPPKLIKRDVLPIVSLIPGCGIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  86 QlidaqNGQPLpTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLTR-- 163
Cdd:PRK14570  81 V-----NNKNL-EIDVVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPFIGFRKyd 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 164 --ANRHNISfAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDNPQA 241
Cdd:PRK14570 155 yfLDKEGIK-KDIKEVLGYPVIVKPAVLGSSIGINVAYNENQIEKCIEEAFKYDLTVVIEKFIEAREIECSVIGNEQIKI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 242 STCGEIVLTS-DFYAYDTKYIDEDGAKVV--VPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPE-NEVVINEIN 317
Cdd:PRK14570 234 FTPGEIVVQDfIFYDYDAKYSTIPGNSIVfnIPAHLDTKHLLDIKEYAFLTYKNLELRGMARIDFLIEKDtGLIYLNEIN 313

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 693209736 318 TLPGFTNISMYPKLWQASGLGYTDLITRLIELALERHA 355
Cdd:PRK14570 314 TIPGFTDISMFAKMCEHDGLQYKSLVDNLIDLAFQSYI 351
PRK14572 PRK14572
D-alanyl-alanine synthetase A; Provisional
 3-352 6.47e-56

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173036 [Multi-domain]  Cd Length: 347  Bit Score: 186.26  E-value: 6.47e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   3 KLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHVSdaSNYLLNTDDPAHIALRPSATSLAQVPGK 82
Cdd:PRK14572   1 MAKIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVKPILLTPDGGWVVP--TVYRPSIPDESGNSEDLFLEEFQKANGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  83 HEHQLIDAQNgqplptVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITLT 162
Cdd:PRK14572  79 SEPADISQLD------ADIAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFFELE 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 163 RANRHNISFAEVES--KLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVL-----G 235
Cdd:PRK14572 153 KLKYLNSPRKTLLKleSLGFPQFLKPVEGGSSVSTYKITNAEQLMTLLALIFESDSKVMSQSFLSGTEVSCGVLeryrgG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 236 NDNPQASTCGEIVLTSDFYAYDTKYiDEDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDvFLTPENEVVINE 315
Cdd:PRK14572 233 KRNPIALPATEIVPGGEFFDFESKY-KQGGSEEITPARISDQEMKRVQELAIRAHESLGCKGYSRTD-FIIVDGEPHILE 310

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 693209736 316 INTLPGFTNISMYPKLWQASGLGYTDLITRLIELALE 352
Cdd:PRK14572 311 TNTLPGMTETSLIPQQAKAAGINMEEVFTDLIEIGLK 347
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
2-353 3.72e-54

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 190.80  E-value: 3.72e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   2 EKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWhvSDASNYLLNTDDPAhialrpsatslaqvpG 81
Cdd:PRK14573 450 KKLSLGLVCGGKSCEHDISLLSAKNIAKYLSPEFYDVSYFLINRQGLW--ETVSSLETAIEEDS---------------G 512

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  82 KHehqLIDAQNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFITL 161
Cdd:PRK14573 513 KS---VLSSEIAQALAKVDVVLPILHGPFGEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASDVGVPVVPYQPL 589

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 162 TRA---NRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKG-REIECAVLGND 237
Cdd:PRK14573 590 TLAgwkREPELCLAHIVEAFSFPMFVKTAHLGSSIGVFEVHNVEELRDKISEAFLYDTDVFVEESRLGsREIEVSCLGDG 669

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 238 N-------PQaSTCGEivltSDFYAYDTKY--IDEDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPE 308
Cdd:PRK14573 670 SsayviagPH-ERRGS----GGFIDYQEKYglSGKSSAQIVFDLDLSKESQEQVLELAERIYRLLQGKGSCRIDFFLDEE 744

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 693209736 309 NEVVINEINTLPGFTNISMYPKLWQASGLGYTDLITRLIELALER 353
Cdd:PRK14573 745 GNFWLSEMNPIPGMTEASPFLTAFVRKGWTYEQIVHQLIIDGLHK 789
PRK14571 PRK14571
D-alanyl-alanine synthetase A; Provisional
 4-350 3.51e-49

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 184751 [Multi-domain]  Cd Length: 299  Bit Score: 167.31  E-value: 3.51e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   4 LRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKqgqwhvsdasNYLLNTDDpahialrpsatslaqvpgkh 83
Cdd:PRK14571   1 MRVALLMGGVSREREISLRSGERVKKALEKLGYEVTVFDVDE----------DFLKKVDQ-------------------- 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  84 ehqlidaqngqpLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAgLNIAPFITltr 163
Cdd:PRK14571  51 ------------LKSFDVVFNVLHGTFGEDGTLQAILDFLGIRYTGSDAFSSMICFDKLLTYRFLKGT-VEIPDFVE--- 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 164 anrhnISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGIKGREIECAVLG-NDNPQAS 242
Cdd:PRK14571 115 -----IKEFMKTSPLGYPCVVKPRREGSSIGVFICESDEEFQHALKEDLPRYGSVIVQEYIPGREMTVSILEtEKGFEVL 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 243 TCGEIVLTSDFYAYDTKYIDEDgAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTpENEVVINEINTLPGF 322
Cdd:PRK14571 190 PILELRPKRRFYDYVAKYTKGE-TEFILPAPLNPEEERLVKETALKAFVEAGCRGFGRVDGIFS-DGRFYFLEINTVPGL 267

                        330       340
                 ....*....|....*....|....*...
gi 693209736 323 TNISMYPKLWQASGLGYTDLITRLIELA 350
Cdd:PRK14571 268 TELSDLPASAKAGGIEFEELVDIIIKSA 295
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 5-130 1.22e-44

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 149.68  E-value: 1.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736    5 RVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVLLGIDKQGQWHvsDASNYLLNTDDPAHIALRPSAtslaqvPGKHE 84
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDKEKYEVIPIGITKDGRLG--EAALRELASDDGLLLEVDDAP------DGGPA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 693209736   85 HQLIDAQNGQPLPTVDVIFPIVHGTLGEDGSLQGMLRVANLPFVGS 130
Cdd:pfam01820  73 GLLFGPNVLELLIEVDVVFPVLHGPNGEDGTLQGLLELAGIPYVGS 118
PRK14569 PRK14569
D-alanyl-alanine synthetase A; Provisional
 1-350 1.82e-33

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173033 [Multi-domain]  Cd Length: 296  Bit Score: 125.94  E-value: 1.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736   1 MEKLRVGIVFGGKSAEHEVSLQSAKNIVDAIDKSRFDVVllGIDKQGQWHVSDAsnyllntddpahIALRPsatslaqvp 80
Cdd:PRK14569   1 MKNEKIVVLYGGDSPEREVSLKSGKAVLDSLISQGYDAV--GVDASGKELVAKL------------LELKP--------- 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  81 gkhehqlidaqngqplptvDVIFPIVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLN--IAPF 158
Cdd:PRK14569  58 -------------------DKCFVALHGEDGENGRVSALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPtpMAKF 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 159 ITLTRANRHNISFaevesklglPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDhKVIVEQGIKGREIECAVLGNDn 238
Cdd:PRK14569 119 LTDKLVAEDEISF---------PVAVKPSSGGSSIATFKVKSIQELKHAYEEASKYG-EVMIEQWVTGKEITVAIVNDE- 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 239 pqASTCGEIVLTSDFYAYDTKYideDGAKVV-VPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEIN 317
Cdd:PRK14569 188 --VYSSVWIEPQNEFYDYESKY---SGKSIYhSPSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRGNFYIMEIN 262

                        330       340       350
                 ....*....|....*....|....*....|...
gi 693209736 318 TLPGFTNISMYPKLWQASGLGYTDLITRLIELA 350
Cdd:PRK14569 263 SSPGMTDNSLSPKSAAAEGVDFDSFVKRIIEQA 295
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 124-351 6.02e-26

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 104.57  E-value: 6.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 124 NLPFVGSDvlASAACMDKDVTKRLLRDAGLNIAPFITLTRANrHNISFAEvesKLGLPLFVKPANQGSSVGVSKVTSEEQ 203
Cdd:COG0439   40 GLPGPSPE--AIRAMRDKVLMREALAAAGVPVPGFALVDSPE-EALAFAE---EIGYPVVVKPADGAGSRGVRVVRDEEE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 204 Y------TIAVDLAFEFDHKVIVEQGIKGREIECAVLGNDnpqastcGEIVLTSDF-YAYDTKYIDEDGAkvVVPAAIAP 276
Cdd:COG0439  114 LeaalaeARAEAKAGSPNGEVLVEEFLEGREYSVEGLVRD-------GEVVVCSITrKHQKPPYFVELGH--EAPSPLPE 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 693209736 277 EINDKIRAIAVQAYQTLG-CAGMARVDVFLTPENEVVINEINT-LPGftniSMYPKLWQ-ASGLgytDLITRLIELAL 351
Cdd:COG0439  185 ELRAEIGELVARALRALGyRRGAFHTEFLLTPDGEPYLIEINArLGG----EHIPPLTElATGV---DLVREQIRLAL 255
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 93-356 1.55e-14

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 73.05  E-value: 1.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  93 GQPLPTVDVIF----PIVHGTlgedgslqGMLRVA---NLPFVgSDVLASAACMDKDVTKRLLRDAGLNIAPfitlTRAN 165
Cdd:COG0189   51 GEDLSEFDAVLpridPPFYGL--------ALLRQLeaaGVPVV-NDPEAIRRARDKLFTLQLLARAGIPVPP----TLVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 166 RHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQ----GIKGREIECAVLGndnpqa 241
Cdd:COG0189  118 RDPDDLRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESILEALTELGSEPVLVQefipEEDGRDIRVLVVG------ 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 242 stcGEIVltsdfYAYDtKYIDEDGAKVVVPA---AIAPEINDKIRAIAVQAYQTLGcAGMARVDVFLTPENEVVInEINT 318
Cdd:COG0189  192 ---GEPV-----AAIR-RIPAEGEFRTNLARggrAEPVELTDEERELALRAAPALG-LDFAGVDLIEDDDGPLVL-EVNV 260

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 693209736 319 LPGFTNISmypklwQASGLgytDLITRLIElALERHAA 356
Cdd:COG0189  261 TPGFRGLE------RATGV---DIAEAIAD-YLEARAA 288
ATP-grasp pfam02222
ATP-grasp domain; This family does not contain all known ATP-grasp domain members. This family ...
 149-316 9.78e-13

ATP-grasp domain; This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 396689 [Multi-domain]  Cd Length: 169  Bit Score: 65.74  E-value: 9.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  149 RDAGLNIAPFITLTRANrhniSFAEVESKLGLPLFVKPANQGSS-VGVSKVTSEEQYTIAVDLAFefDHKVIVEQGIKgR 227
Cdd:pfam02222   1 QKLGLPTPRFMAAESLE----ELIEAGQELGYPCVVKARRGGYDgKGQYVVRSEADLPQAWEELG--DGPVIVEEFVP-F 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  228 EIECAVLGNDNPQASTcgeivltsdfYAYD---TKYIDEDGAKVVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVF 304
Cdd:pfam02222  74 DRELSVLVVRSVDGET----------AFYPvveTIQEDGICRLSVAPARVPQAIQAEAQDIAKRLVDELGGVGVFGVELF 143

                         170
                  ....*....|..
gi 693209736  305 LTPENEVVINEI 316
Cdd:pfam02222 144 VTEDGDLLINEL 155
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 138-317 7.82e-12

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 65.68  E-value: 7.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 138 CMDKDVTKRLLRDAGLNIApfITLTRANRHNISFAEVESKLGLPLFVKPANQGSSVGVSKVTSEEQytiaVDLAFEFDHK 217
Cdd:PRK12767 109 CNDKWLTYEFLKENGIPTP--KSYLPESLEDFKAALAKGELQFPLFVKPRDGSASIGVFKVNDKEE----LEFLLEYVPN 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 218 VIVEQGIKGREIECAVLgND---NPQASTCGE-IVLTSDfyAYDTKYIDEDgakvvvpaaiaPEINDKIRAIAvqayQTL 293
Cdd:PRK12767 183 LIIQEFIEGQEYTVDVL-CDlngEVISIVPRKrIEVRAG--ETSKGVTVKD-----------PELFKLAERLA----EAL 244

                        170       180
                 ....*....|....*....|....
gi 693209736 294 GCAGMARVDVFLTpENEVVINEIN 317
Cdd:PRK12767 245 GARGPLNIQCFVT-DGEPYLFEIN 267
PurK COG0026
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and ...
 129-316 1.21e-09

Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439797 [Multi-domain]  Cd Length: 353  Bit Score: 58.93  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 129 GSDVLAsaACMDKDVTKRLLRDAGLNIAPFITLTranrhniSFAEVES---KLGLPLFVKPANQGS-SVGVSKVTSEEQy 204
Cdd:COG0026   80 GPEALE--IAQDRLLEKAFLAELGIPVAPFAAVD-------SLEDLEAaiaELGLPAVLKTRRGGYdGKGQVVIKSAAD- 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 205 tiaVDLAFEFDHKV--IVEQGIK-GREIecAVLGNDNPQastcGEIVltsdfyAYD-TKYIDEDG--AKVVVPAAIAPEI 278
Cdd:COG0026  150 ---LEAAWAALGGGpcILEEFVPfEREL--SVIVARSPD----GEVA------TYPvVENVHRNGilDESIAPARISEAL 214

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 693209736 279 NDKIRAIAVQAYQTLGCAG-MArVDVFLTPENEVVINEI 316
Cdd:COG0026  215 AAEAEEIAKRIAEALDYVGvLA-VEFFVTKDGELLVNEI 252
PRK06019 PRK06019
phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed
 127-316 2.91e-09

phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed


Pssm-ID: 235674 [Multi-domain]  Cd Length: 372  Bit Score: 57.86  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 127 FVGSDVLASAAcmDKDVTKRLLRDAGLNIAPFITLTRANrhniSFAEVESKLGLPLFVKPANQGss-vGVSKVTSEEQYT 205
Cdd:PRK06019  89 PPGPDALAIAQ--DRLTEKQFLDKLGIPVAPFAVVDSAE----DLEAALADLGLPAVLKTRRGGydgkGQWVIRSAEDLE 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 206 IAVDlafEFDHK-VIVEQGIKGREiECAVLGNDNPQastcGEIVltsdfyAYD-TKYIDEDG--AKVVVPAAIAPEINDK 281
Cdd:PRK06019 163 AAWA---LLGSVpCILEEFVPFER-EVSVIVARGRD----GEVV------FYPlVENVHRNGilRTSIAPARISAELQAQ 228

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 693209736 282 IRAIAVQAYQTLGCAG-MArVDVFLTPENEVVINEI 316
Cdd:PRK06019 229 AEEIASRIAEELDYVGvLA-VEFFVTGDGELLVNEI 263
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 137-228 7.24e-08

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 54.01  E-value: 7.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 137 ACmDKDVTKRLLRDAGLNIaPFITLTRanrhniSFAEVES---KLGLPLFVKP--ANQGSsvGVS-KVTSEEQYTIAVDL 210
Cdd:PRK14016 212 AC-DKELTKRLLAAAGVPV-PEGRVVT------SAEDAWEaaeEIGYPVVVKPldGNHGR--GVTvNITTREEIEAAYAV 281

                         90
                 ....*....|....*...
gi 693209736 211 AFEFDHKVIVEQGIKGRE 228
Cdd:PRK14016 282 ASKESSDVIVERYIPGKD 299
PRK02471 PRK02471
bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;
131-237 1.32e-06

bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB;


Pssm-ID: 179427 [Multi-domain]  Cd Length: 752  Bit Score: 50.31  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 131 DVLASAACMD-KDVTKRLLRDAGLNI---APFITLTRANRhniSFAEVESKlglPLFVKPANQGSSVGVS---KVTSEEQ 203
Cdd:PRK02471 478 DNYISPLIMEnKVVTKKILAEAGFPVpagDEFTSLEEALA---DYSLFADK---AIVVKPKSTNFGLGISifkEPASLED 551

                         90       100       110
                 ....*....|....*....|....*....|....
gi 693209736 204 YTIAVDLAFEFDHKVIVEQGIKGREIECAVLGND 237
Cdd:PRK02471 552 YEKALEIAFREDSSVLVEEFIVGTEYRFFVLDGK 585
PRK10446 PRK10446
30S ribosomal protein S6--L-glutamate ligase;
179-362 2.45e-04

30S ribosomal protein S6--L-glutamate ligase;


Pssm-ID: 182468 [Multi-domain]  Cd Length: 300  Bit Score: 42.58  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 179 GLPLFVKPANQGSSVGVSKVTSEEQYTIAVDLAFEFDHKVIVEQGI---KGREIECAVLGNdnpqastcgEIVLTSDFYA 255
Cdd:PRK10446 135 GAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIkeaQGCDIRCLVVGD---------EVVAAIERRA 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 256 YDTKY---IDEDGAKVVVpaaiapEINDKIRAIAVQAYQTLGCaGMARVDVFLTPENEVVInEINTLPGFTNISmypklw 332
Cdd:PRK10446 206 KEGDFrsnLHRGGAASVA------SITPQEREIAIKAARTMAL-DVAGVDILRANRGPLVM-EVNASPGLEGIE------ 271

                        170       180       190
                 ....*....|....*....|....*....|.
gi 693209736 333 QASGLgytDLITRLIELaLERHAADN-ALKT 362
Cdd:PRK10446 272 KTTGI---DIAGKMIRW-IERHATTEyCLKT 298
PLN02948 PLN02948
phosphoribosylaminoimidazole carboxylase
 268-316 5.92e-04

phosphoribosylaminoimidazole carboxylase


Pssm-ID: 178534 [Multi-domain]  Cd Length: 577  Bit Score: 41.58  E-value: 5.92e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 693209736 268 VVVPAAIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEI 316
Cdd:PLN02948 238 VEAPANVPWKVAKLATDVAEKAVGSLEGAGVFGVELFLLKDGQILLNEV 286
rimK_fam TIGR00768
alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione ...
 134-328 6.23e-04

alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).


Pssm-ID: 273261 [Multi-domain]  Cd Length: 276  Bit Score: 41.18  E-value: 6.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  134 ASAACMDKDVTKRLLRDAGLnIAPfITLTRANRHN-ISFAEvesKLGLPLFVKPANQGSSVGVSKVTsEEQYTIAVDLAF 212
Cdd:TIGR00768  82 AILNAGDKFLSHQLLAKAGI-PLP-RTGLAGSPEEaLKLIE---EIGFPVVLKPVFGSWGRGVSLAR-DRQAAESLLEHF 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736  213 E----FDHKVIVEQGIK---GREIECAVLGNDNPQA-STCGEivltSDFYAYDTKyidedGAKvvvpaAIAPEINDKIRA 284
Cdd:TIGR00768 156 EqlngPQNLFLVQEYIKkpgGRDIRVFVVGDEVVAAiYRITS----GHWRSNLAR-----GGK-----AEPCSLTEEIEE 221

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 693209736  285 IAVQAYQTLGcAGMARVDvFLTPENEVVINEINTLPGFTNISMY 328
Cdd:TIGR00768 222 LAIKAAKALG-LDVAGVD-LLESEDGLLVNEVNANPEFKNSVKT 263
PRK05586 PRK05586
acetyl-CoA carboxylase biotin carboxylase subunit;
108-318 8.65e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 180150 [Multi-domain]  Cd Length: 447  Bit Score: 37.77  E-value: 8.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 108 GTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLNIAPFitlTRANRHNISFA-EVESKLGLPLFVKP 186
Cdd:PRK05586  83 GFLSENSKFAKMCKECNIVFIGPDSETIELMGNKSNAREIMIKAGVPVVPG---SEGEIENEEEAlEIAKEIGYPVMVKA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 187 ANQGSSVGVSKVTSEEQYTIAVD------LAFEFDHKVIVEQGI-KGREIECAVLGNDnpqastCGEIVLTSD----FYA 255
Cdd:PRK05586 160 SAGGGGRGIRIVRSEEELIKAFNtakseaKAAFGDDSMYIEKFIeNPKHIEFQILGDN------YGNVVHLGErdcsLQR 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 693209736 256 YDTKYIDEDGAKVvvpaaIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINT 318
Cdd:PRK05586 234 RNQKVLEEAPSPV-----MTEELRKKMGEIAVKAAKAVNYKNAGTIEFLLDKDGNFYFMEMNT 291
PRK08462 PRK08462
acetyl-CoA carboxylase biotin carboxylase subunit;
100-318 9.80e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236269 [Multi-domain]  Cd Length: 445  Bit Score: 37.80  E-value: 9.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 100 DVIFPiVHGTLGEDGSLQGMLRVANLPFVGSDVLASAACMDKDVTKRLLRDAGLniaPFITLTRANRHNISFA-EVESKL 178
Cdd:PRK08462  78 DAIFP-GYGFLSENQNFVEICSHHNIKFIGPSVEVMALMSDKSKAKEVMKRAGV---PVIPGSDGALKSYEEAkKIAKEI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 693209736 179 GLPLFVKPANQGSSVGVSKVTSEEQ----YTIAVDLAFEF--DHKVIVEQGI-KGREIECAVLGNDNPQASTCGEivltS 251
Cdd:PRK08462 154 GYPVILKAAAGGGGRGMRVVEDESDlenlYLAAESEALSAfgDGTMYMEKFInNPRHIEVQILGDKHGNVIHVGE----R 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 693209736 252 DFYAYD--TKYIDEDGAKVvvpaaIAPEINDKIRAIAVQAYQTLGCAGMARVDVFLTPENEVVINEINT 318
Cdd:PRK08462 230 DCSLQRrhQKLIEESPAVV-----LDEKTRERLHETAIKAAKAIGYEGAGTFEFLLDSNLDFYFMEMNT 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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