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Conserved domains on  [gi|692190216|ref|WP_032104122|]
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MULTISPECIES: LuxR C-terminal-related transcriptional regulator [Enterobacter]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10677008)

helix-turn-helix (HTH) transcriptional regulator containing a LuxR family HTH DNA-binding domain; may act as a transcription activator/repressor, or have a dual role for different sites

Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 137-187 9.44e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


:

Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 57.54  E-value: 9.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 692190216   137 APLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSR 51
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
39-187 2.93e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


:

Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 54.38  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216  39 LFLAREHILQWKPALVIADLSGFRQDLHHFQQLSSLLIASETLPFIMLQSGQEQEMTDYLAQFPIWSSLSKNTDLEKLAA 118
Cdd:COG2771   27 LLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLL 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692190216 119 VINDALTTCVSAELPEMAAPLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:COG2771  107 ALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSR 175
 
Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 137-187 9.44e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 57.54  E-value: 9.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 692190216   137 APLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSR 51
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 140-188 1.37e-11

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 57.16  E-value: 1.37e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 692190216 140 LTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTRY 188
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRT 49
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 134-187 5.26e-11

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 5.26e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 692190216 134 EMAAPLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:COG2197   64 EALRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNR 117
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
39-187 2.93e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 54.38  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216  39 LFLAREHILQWKPALVIADLSGFRQDLHHFQQLSSLLIASETLPFIMLQSGQEQEMTDYLAQFPIWSSLSKNTDLEKLAA 118
Cdd:COG2771   27 LLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLL 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692190216 119 VINDALTTCVSAELPEMAAPLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:COG2771  107 ALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSR 175
GerE pfam00196
Bacterial regulatory proteins, luxR family;
140-182 6.51e-08

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 47.58  E-value: 6.51e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 692190216  140 LTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKL 182
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKL 45
rcsA PRK15411
transcriptional regulator RcsA;
5-187 5.16e-06

transcriptional regulator RcsA;


Pssm-ID: 185309 [Multi-domain]  Cd Length: 207  Bit Score: 45.12  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216   5 LLIDRCHFTRTGFEAWL-NHSDLFSGHFVVTGVNNLflaREHILQWKPALVIADLSGFRQDLHHFQQLSSLLIASETLPF 83
Cdd:PRK15411   4 IIMDLCSYTRLGLTGYLlSRGVKKREINDIETVDDL---AIACDSLRPSVVFINEDCFIHDASNSQRIKQIINQHPNTLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216  84 IMLQSGQEQEMTDYLaqfPIWSSL---SKNTDLEKLAAVINDALTTCVSAELPEMAAPL-LTRQEERVLTLWMDGASNQK 159
Cdd:PRK15411  81 IVFMAIANIHFDEYL---LVRKNLlisSKSIKPESLDDLLGDILKKETTITSFLNLPTLsLSRTESSMLRMWMAGQGTIQ 157

                        170       180
                 ....*....|....*....|....*...
gi 692190216 160 IASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:PRK15411 158 ISDQMNIKAKTVSSHKGNIKRKIKTHNK 185
PRK15369 PRK15369
two component system response regulator;
138-182 2.07e-05

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 43.53  E-value: 2.07e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 692190216 138 PLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKL 182
Cdd:PRK15369 148 PLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKL 192
 
Name Accession Description Interval E-value
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 137-187 9.44e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 57.54  E-value: 9.44e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 692190216   137 APLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSR 51
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 140-188 1.37e-11

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 57.16  E-value: 1.37e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 692190216 140 LTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTRY 188
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRT 49
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 134-187 5.26e-11

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 5.26e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 692190216 134 EMAAPLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:COG2197   64 EALRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNR 117
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
39-187 2.93e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 54.38  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216  39 LFLAREHILQWKPALVIADLSGFRQDLHHFQQLSSLLIASETLPFIMLQSGQEQEMTDYLAQFPIWSSLSKNTDLEKLAA 118
Cdd:COG2771   27 LLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLALLLLLALLALLAALLARLAALLL 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 692190216 119 VINDALTTCVSAELPEMAAPLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:COG2771  107 ALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSR 175
GerE pfam00196
Bacterial regulatory proteins, luxR family;
140-182 6.51e-08

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 47.58  E-value: 6.51e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 692190216  140 LTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKL 182
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKL 45
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 138-187 3.97e-06

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 43.02  E-value: 3.97e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 692190216 138 PLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:COG5905   11 SLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNR 60
rcsA PRK15411
transcriptional regulator RcsA;
5-187 5.16e-06

transcriptional regulator RcsA;


Pssm-ID: 185309 [Multi-domain]  Cd Length: 207  Bit Score: 45.12  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216   5 LLIDRCHFTRTGFEAWL-NHSDLFSGHFVVTGVNNLflaREHILQWKPALVIADLSGFRQDLHHFQQLSSLLIASETLPF 83
Cdd:PRK15411   4 IIMDLCSYTRLGLTGYLlSRGVKKREINDIETVDDL---AIACDSLRPSVVFINEDCFIHDASNSQRIKQIINQHPNTLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216  84 IMLQSGQEQEMTDYLaqfPIWSSL---SKNTDLEKLAAVINDALTTCVSAELPEMAAPL-LTRQEERVLTLWMDGASNQK 159
Cdd:PRK15411  81 IVFMAIANIHFDEYL---LVRKNLlisSKSIKPESLDDLLGDILKKETTITSFLNLPTLsLSRTESSMLRMWMAGQGTIQ 157

                        170       180
                 ....*....|....*....|....*...
gi 692190216 160 IASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:PRK15411 158 ISDQMNIKAKTVSSHKGNIKRKIKTHNK 185
PRK15369 PRK15369
two component system response regulator;
138-182 2.07e-05

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 43.53  E-value: 2.07e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 692190216 138 PLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKL 182
Cdd:PRK15369 148 PLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKL 192
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
107-182 9.92e-04

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 38.72  E-value: 9.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216 107 LSKNTDLEKLAAVINDALTT-----------CVSAELPEMAAPLLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYK 175
Cdd:PRK09958 100 VSKKEGMNNIIAAIEAAKNGycyfpfslnrfVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYK 179


                 ....*..
gi 692190216 176 RNIRMKL 182
Cdd:PRK09958 180 SRLMEKL 186
PRK08295 PRK08295
RNA polymerase sporulation sigma factor SigH;
108-171 1.27e-03

RNA polymerase sporulation sigma factor SigH;


Pssm-ID: 181361 [Multi-domain]  Cd Length: 208  Bit Score: 38.35  E-value: 1.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 692190216 108 SKNTDLEKLaaVINDALTTCVSAELPEMaaplLTRQEERVLTLWMDGASNQKIASNLRINGKTV 171
Cdd:PRK08295 130 AKVTDPEEL--IISKEELEDIEEKIEEL----LSELEKEVLELYLDGKSYQEIAEELNRHVKSI 187
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
112-187 2.58e-03

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 37.38  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 692190216 112 DLEKLAAVINDALTTCVSAELPEMAAPLLTRQEERVLTLWM-------DGASNQKIASNLRINGKTVYTYKRNIRMKLHM 184
Cdd:COG2909   88 DPEEALALLERLLALAEAAGRLLLRALALRALGDREEALAAlrrrllaEGLSNKEIAERLFISVNTVKTHLRNIYRKLGV 167


                 ...
gi 692190216 185 DTR 187
Cdd:COG2909  168 RSR 170
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
139-187 8.86e-03

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 35.98  E-value: 8.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 692190216 139 LLTRQEERVLTLWMDGASNQKIASNLRINGKTVYTYKRNIRMKLHMDTR 187
Cdd:PRK10403 153 VLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSR 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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