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Conserved domains on  [gi|686380253|ref|WP_031899682|]
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N-acetylglucosaminidase, partial [Staphylococcus aureus]

Protein Classification

N-acetylglucosaminidase( domain architecture ID 11467967)

N-acetylglucosaminidase such as Staphylococcus aureus N-acetylglucosaminidase autolysin E (AtlE) that is involved in the degradation of cell wall peptidoglycan

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LytD COG4193
Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism];
191-427 4.46e-72

Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism];


:

Pssm-ID: 443347 [Multi-domain]  Cd Length: 423  Bit Score: 232.55  E-value: 4.46e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 191 TANNGSASKQPQIITETSPYTFKQALDKQMARGNPKKSNAwGWANATRAQTSSAMNVKRIWESNTQCYQMLNLGKYQGVS 270
Cdd:COG4193  176 NVIPTESVPGGNLKHNSYNHSLKSAAAKQYSYSWMYYDGG-GWYSASGSDIAYYMDPRNFLNDEYNYFQFLDLRYSSNYS 254
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 271 VSALNKILKG---KGTLNNQGKAFAEACKKHNINEIYLIAHAFLESGYGTSNFANGKD----GVYNYFGIGAYDNNP-NY 342
Cdd:COG4193  255 AEELNKYLKGtftKGILIGKGQAFIEAAKKYGVNPLYLASHALLETGNGTSKLAKGVEvngkTYYNLFGIGAYDSNPlEN 334
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 343 AMTFARNKGWTSPAKAIMGGASFVRKDYINK---GQNTLYRIRWNPKNPAT-HQYATAIEWCQHQASTIAKLYKQIGLKG 418
Cdd:COG4193  335 GAKYAYKQGWTSPEKAIVGGAKFIGSNYINNtgyGQNTLYKMRWNPVNPGTnHQYATDPFWAEKIAGHMYRAYKKLKDYN 414

                 ....*....
gi 686380253 419 IYFTRDKYK 427
Cdd:COG4193  415 LYFDIPVYK 423
 
Name Accession Description Interval E-value
LytD COG4193
Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism];
191-427 4.46e-72

Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism];


Pssm-ID: 443347 [Multi-domain]  Cd Length: 423  Bit Score: 232.55  E-value: 4.46e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 191 TANNGSASKQPQIITETSPYTFKQALDKQMARGNPKKSNAwGWANATRAQTSSAMNVKRIWESNTQCYQMLNLGKYQGVS 270
Cdd:COG4193  176 NVIPTESVPGGNLKHNSYNHSLKSAAAKQYSYSWMYYDGG-GWYSASGSDIAYYMDPRNFLNDEYNYFQFLDLRYSSNYS 254
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 271 VSALNKILKG---KGTLNNQGKAFAEACKKHNINEIYLIAHAFLESGYGTSNFANGKD----GVYNYFGIGAYDNNP-NY 342
Cdd:COG4193  255 AEELNKYLKGtftKGILIGKGQAFIEAAKKYGVNPLYLASHALLETGNGTSKLAKGVEvngkTYYNLFGIGAYDSNPlEN 334
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 343 AMTFARNKGWTSPAKAIMGGASFVRKDYINK---GQNTLYRIRWNPKNPAT-HQYATAIEWCQHQASTIAKLYKQIGLKG 418
Cdd:COG4193  335 GAKYAYKQGWTSPEKAIVGGAKFIGSNYINNtgyGQNTLYKMRWNPVNPGTnHQYATDPFWAEKIAGHMYRAYKKLKDYN 414

                 ....*....
gi 686380253 419 IYFTRDKYK 427
Cdd:COG4193  415 LYFDIPVYK 423
LYZ2 smart00047
Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.
276-413 1.31e-37

Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.


Pssm-ID: 214488 [Multi-domain]  Cd Length: 147  Bit Score: 133.72  E-value: 1.31e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253   276 KILKGKGTLNNQGKAFAEACKKHNINEIY---LIAHAFLESGYGTSNFAngkDGVYNYFGI-GAYDNNPNYAMT-FARNK 350
Cdd:smart00047   1 KLLAGGSTLEFVGKIFNEAQKAYQINGVYpsiLIAQAALESGWGTSKLA---KKYNNLFGIkGAYDGRPVRMGTlEYLNG 77
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686380253   351 GWTSPAKAIMG--GASFVRKDYINKGQNTLYRIRWNPKNPATHQYATAIEWCQHQASTIAKLYKQ 413
Cdd:smart00047  78 GWVTVKAAFRGyfGEKFIDYAYVLRGQNPLYKKRWGSNALQTAGYATDPDYAKKLIRIIALYDEK 142
Glucosaminidase pfam01832
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes ...
288-361 7.32e-12

Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J that has been shown to hydrolyse peptidoglycan.


Pssm-ID: 460354 [Multi-domain]  Cd Length: 91  Bit Score: 61.05  E-value: 7.32e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686380253  288 GKAFAEACKKHNINEIYLIAHAFLESGYGTSNFANGKdgvYNYFGIGAYDNNPNYAMTFARNKG-----WTSPAKAIMG 361
Cdd:pfam01832   1 APAAIEAAKKYGIPASVLLAQAALESGWGTSRLAKES---NNLFGIKASWKGKVAYDTDEVTVAarfrkYDSVEESIRD 76
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
165-368 1.82e-03

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 40.45  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 165 TVTKSRIKVMV---DNKNADIAnVRDSSPTANNGSASKQPQIITETSPYTFKQALDKQMARGNPKKSNAWGWANATRAQT 241
Cdd:PRK06347  40 SITVPGIEVIVsadETAPADEA-SKSAEANTTKEAPATATPENTTEPTVEPKQTETKEQTKTPEEKQPAAKQVEKAPAEP 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 242 SSAMNVKRIWESNTQcyqmlnlGKYQGVSVSALNKILKGKGTLNNQGKAFAEACKKHNINEIYLIAHAFLESGYGTSNFA 321
Cdd:PRK06347 119 ATVSNPDNATSSSTP-------ATYNLLQKSALRSGATVQSFIQTIQASSSQIAAENDLYASVMIAQAILESAYGTSELG 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 322 NGKDgvYNYFGI-GAY------------DNNPNYAMTFARNKGWTSPAKAIMGGASFVRK 368
Cdd:PRK06347 192 SAPN--YNLFGIkGAYngqsytkqtledDGKGNYYTITAKFRKYPSYHQSLEDYAQVIRK 249
 
Name Accession Description Interval E-value
LytD COG4193
Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism];
191-427 4.46e-72

Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism];


Pssm-ID: 443347 [Multi-domain]  Cd Length: 423  Bit Score: 232.55  E-value: 4.46e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 191 TANNGSASKQPQIITETSPYTFKQALDKQMARGNPKKSNAwGWANATRAQTSSAMNVKRIWESNTQCYQMLNLGKYQGVS 270
Cdd:COG4193  176 NVIPTESVPGGNLKHNSYNHSLKSAAAKQYSYSWMYYDGG-GWYSASGSDIAYYMDPRNFLNDEYNYFQFLDLRYSSNYS 254
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 271 VSALNKILKG---KGTLNNQGKAFAEACKKHNINEIYLIAHAFLESGYGTSNFANGKD----GVYNYFGIGAYDNNP-NY 342
Cdd:COG4193  255 AEELNKYLKGtftKGILIGKGQAFIEAAKKYGVNPLYLASHALLETGNGTSKLAKGVEvngkTYYNLFGIGAYDSNPlEN 334
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 343 AMTFARNKGWTSPAKAIMGGASFVRKDYINK---GQNTLYRIRWNPKNPAT-HQYATAIEWCQHQASTIAKLYKQIGLKG 418
Cdd:COG4193  335 GAKYAYKQGWTSPEKAIVGGAKFIGSNYINNtgyGQNTLYKMRWNPVNPGTnHQYATDPFWAEKIAGHMYRAYKKLKDYN 414

                 ....*....
gi 686380253 419 IYFTRDKYK 427
Cdd:COG4193  415 LYFDIPVYK 423
LYZ2 smart00047
Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.
276-413 1.31e-37

Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.


Pssm-ID: 214488 [Multi-domain]  Cd Length: 147  Bit Score: 133.72  E-value: 1.31e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253   276 KILKGKGTLNNQGKAFAEACKKHNINEIY---LIAHAFLESGYGTSNFAngkDGVYNYFGI-GAYDNNPNYAMT-FARNK 350
Cdd:smart00047   1 KLLAGGSTLEFVGKIFNEAQKAYQINGVYpsiLIAQAALESGWGTSKLA---KKYNNLFGIkGAYDGRPVRMGTlEYLNG 77
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686380253   351 GWTSPAKAIMG--GASFVRKDYINKGQNTLYRIRWNPKNPATHQYATAIEWCQHQASTIAKLYKQ 413
Cdd:smart00047  78 GWVTVKAAFRGyfGEKFIDYAYVLRGQNPLYKKRWGSNALQTAGYATDPDYAKKLIRIIALYDEK 142
Glucosaminidase pfam01832
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes ...
288-361 7.32e-12

Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J that has been shown to hydrolyse peptidoglycan.


Pssm-ID: 460354 [Multi-domain]  Cd Length: 91  Bit Score: 61.05  E-value: 7.32e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686380253  288 GKAFAEACKKHNINEIYLIAHAFLESGYGTSNFANGKdgvYNYFGIGAYDNNPNYAMTFARNKG-----WTSPAKAIMG 361
Cdd:pfam01832   1 APAAIEAAKKYGIPASVLLAQAALESGWGTSRLAKES---NNLFGIKASWKGKVAYDTDEVTVAarfrkYDSVEESIRD 76
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
165-368 1.82e-03

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 40.45  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 165 TVTKSRIKVMV---DNKNADIAnVRDSSPTANNGSASKQPQIITETSPYTFKQALDKQMARGNPKKSNAWGWANATRAQT 241
Cdd:PRK06347  40 SITVPGIEVIVsadETAPADEA-SKSAEANTTKEAPATATPENTTEPTVEPKQTETKEQTKTPEEKQPAAKQVEKAPAEP 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 242 SSAMNVKRIWESNTQcyqmlnlGKYQGVSVSALNKILKGKGTLNNQGKAFAEACKKHNINEIYLIAHAFLESGYGTSNFA 321
Cdd:PRK06347 119 ATVSNPDNATSSSTP-------ATYNLLQKSALRSGATVQSFIQTIQASSSQIAAENDLYASVMIAQAILESAYGTSELG 191
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 686380253 322 NGKDgvYNYFGI-GAY------------DNNPNYAMTFARNKGWTSPAKAIMGGASFVRK 368
Cdd:PRK06347 192 SAPN--YNLFGIkGAYngqsytkqtledDGKGNYYTITAKFRKYPSYHQSLEDYAQVIRK 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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