|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-354 |
3.58e-69 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 222.06 E-value: 3.58e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGArWDYIGIFSFLL 167
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIIFFIDIPNVEKG--IVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVL 245
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAksSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 246 FLPITVSVILGSLFYKRFSKKynEIMILRVTITGFAMFTLLFGWLNES-NVIILSVIIFILGTCVGIVPALLATIISKRF 324
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKK--RFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350
....*....|....*....|....*....|.
gi 686343253 325 -EHIKGKVLGVFNFVRYIGMTVGALLIGIIS 354
Cdd:cd17474 318 pEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-345 |
1.43e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.57 E-value: 1.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLL 167
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIIFFIdIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFL 247
Cdd:COG2814 172 VLALLALLLLLRL-LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 248 PITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLneSNVIILSVIIFILGTCVGIVPALLATIISKRF-EH 326
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPE 328
|
330
....*....|....*....
gi 686343253 327 IKGKVLGVFNFVRYIGMTV 345
Cdd:COG2814 329 ARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
10-353 |
7.82e-31 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 121.14 E-value: 7.82e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 10 ILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICA 89
Cdd:cd17320 3 LLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 90 VTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVI 169
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 170 SIVLF-LIIFFIDIPNVEKGIVKLTEKIEEKY---LTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVL 245
Cdd:cd17320 163 GLLLLlLVLLFLPETLPEEKRKPLLSSLLRAYkrvLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 246 FLPITVSVILGSLFYKRFSKKYNEIMILRVTITGF---AMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISK 322
Cdd:cd17320 243 FALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLlaaALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE 322
|
330 340 350
....*....|....*....|....*....|.
gi 686343253 323 RFEHIKGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:cd17320 323 PFPHVAGTASALLGFLQFLIGALAGALVGLL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-355 |
5.21e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 104.55 E-value: 5.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLL 167
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIIFFIdIPNV--EKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVL 245
Cdd:cd17324 161 VLALLAALLLWRL-LPSLppKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 246 FLPITVSVILGSLFYKRFSKKYNEIMILrvTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISKRFE 325
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALL--IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350
....*....|....*....|....*....|
gi 686343253 326 HIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLD 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-355 |
6.02e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.58 E-value: 6.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAV 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 91 THNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVIS 170
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 171 IVLFLIIFFID-----IPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVL 245
Cdd:cd17325 161 LLALVLALLLLpeprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 246 FLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLneSNVIILSVIIFILGTCVGIVPALLATIISKRF- 324
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVFPATLALLADIVp 318
|
330 340 350
....*....|....*....|....*....|.
gi 686343253 325 EHIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-347 |
6.51e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.26 E-value: 6.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPR-LYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICA 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 90 VTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVI 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 170 SIVLFLIIFFIDIPNVEKGIVKLTEKIEE-----KYLTDKVFITLVTLGFLIFFTYFSILVYLPtLLNNTYDIGVGISGV 244
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSlivawKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 245 LFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNE-SNVIILSVIIFILGTCVGIVPALLATIISKR 323
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*
gi 686343253 324 F-EHIKGKVLGVFNFVRYIGMTVGA 347
Cdd:pfam07690 320 ApKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-355 |
5.48e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 93.04 E-value: 5.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAV 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 91 THNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVIS 170
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 171 IVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNntyDIGVGISGVLFLPIT 250
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAA---ERGISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 251 VSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGtCVGIVPALLATIISKRFEHIKGK 330
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG-FGLLFPALQALAVDLVPPHRRGA 316
|
330 340
....*....|....*....|....*
gi 686343253 331 VLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAE 341
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
11-355 |
2.51e-20 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 91.48 E-value: 2.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAV 90
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 91 THNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVIS 170
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 171 IVLFLIIFFIDIpnvekgivkltekieeKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPIT 250
Cdd:cd17503 161 ILALLLAPLLDL----------------RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 251 VSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNE-SNVIILSVIIFILGTCVGIVPALLATIISKRFEHIK- 328
Cdd:cd17503 225 LASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQi 304
|
330 340
....*....|....*....|....*...
gi 686343253 329 GKVLGVFNFVRYIGMTVG-ALLIGIISQ 355
Cdd:cd17503 305 GDATALFNTIRQLGGSIGtALLATLLTN 332
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-353 |
3.23e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 91.08 E-value: 3.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 13 FLAFFASLIQNIytpIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTH 92
Cdd:cd17321 6 FLAALDVTIVNV---ALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 93 NFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIV 172
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 173 LFLIIffidipnvekgivkltekieekyltdKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVS 252
Cdd:cd17321 163 ALLLA--------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 253 VILGSLFYKRFSKKYNE--IMILRVTITGFAMFtLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISKRFEHIK-G 329
Cdd:cd17321 217 MLVAAPLAGRLADRFGPrlVLVAGLLLTAVGLL-LLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKaG 295
|
330 340
....*....|....*....|....
gi 686343253 330 KVLGVFNFVRYIGMTVGALLIGII 353
Cdd:cd17321 296 AASGILNTARQLGGALGVALLGAL 319
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-355 |
3.73e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 90.70 E-value: 3.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLL 167
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIiffidipnvekgivkltekieekyltdkVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFL 247
Cdd:COG2271 172 LPGLLLALL----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 248 PITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISKRF-EH 326
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFpKK 303
|
330 340
....*....|....*....|....*....
gi 686343253 327 IKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
26-358 |
4.82e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 90.33 E-value: 4.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 26 TPIIPRLYDDFQ-VPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQ 104
Cdd:cd17473 19 APALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 105 TIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGArWDYIGIFSFLLVISIVLFLIIFFIDIPN 184
Cdd:cd17473 99 GIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 185 VEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFS 264
Cdd:cd17473 178 RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 265 KKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVgIVPALLATIISKRFEHIKGKVLGVFNFVRYIGMT 344
Cdd:cd17473 258 RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL-LLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQF 336
|
330
....*....|....
gi 686343253 345 VGALLIGIISQPLV 358
Cdd:cd17473 337 LSPLVLGPLVNLTG 350
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
41-357 |
1.30e-19 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 89.20 E-value: 1.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 41 FWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQtiGCGIIPLMTLTLLA 120
Cdd:cd17472 32 TLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 121 KLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIV-LFLIIFFIDIPNVEKGIVKLTEKIEEK 199
Cdd:cd17472 110 DLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVsLLILLFFVPDPPKIVQISEKEKKKLKK 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 200 YLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYdIGVGISGVLFLPITVSVILGSLFYKRFSKKYN---EIMILRVT 276
Cdd:cd17472 190 LLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLG-GGKGQLWKVYLPAILIGFILMVPFVIYAEKKGkmkQVFVSSIL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 277 ITGFAMFTLLFGWLNESNVIILSVIIFILGTCV-GIVPALLATIISKrfeHIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17472 269 LIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLeALLPSLVSKIAPK---EYRGTAMGIYNTSQFLGSFLGGALGGLLWG 345
|
..
gi 686343253 356 PL 357
Cdd:cd17472 346 LL 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-355 |
2.61e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 82.59 E-value: 2.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 2 TKSNIRLYILGFLAFFA-SLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGI 80
Cdd:COG0738 3 KKNYRRALIAIYLLFFLwGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 81 VIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRaQAMANYQIFLSCAPTLAPILGSTL---GARW 157
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLLillGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 158 DYIGIFSFLLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKY--LTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTY 235
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKslLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 236 DIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGtCVGIVPAL 315
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG-LSLMFPTI 320
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 686343253 316 LAtIISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:COG0738 321 FS-LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
10-349 |
1.21e-16 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 80.70 E-value: 1.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 10 ILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICA 89
Cdd:cd17323 3 IISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 90 VTHNFILFAISRLFQtiGCGIIPLMTLT--LLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLL 167
Cdd:cd17323 83 LAPNIAMLIILRFLQ--GFFGSSPLAIGagTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIIFFIdIPNvekgivkltekieekyltdkVFITLVTLGFlIFFTYFSILVYLPTLLNNTYDIGVGISGVLFL 247
Cdd:cd17323 161 IISGFCLILIFLF-LPI--------------------VLLLGLYVGL-VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 248 PITVSVILGSLFYKRFSKKY--------NEIMI----LRVTITGFAMFT---LLFGWLNESNVIILSVII--FILGTCVG 310
Cdd:cd17323 219 PIGIGALIGSIIGGRLSDYYyrrlkkknGGKPEpearLPPAFIGAFLFPiglFIFGWTIYPHIHWIVPIIgsAFFGFGLM 298
|
330 340 350
....*....|....*....|....*....|....*....
gi 686343253 311 IVPALLATIISKRFEHIKGKVLGVFNFVRYIGMTVGALL 349
Cdd:cd17323 299 LIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLF 337
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-353 |
5.03e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.62 E-value: 5.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAV 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 91 THNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGS--TLGARWDYIGIFSFLLV 168
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGilASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 169 ISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLT-------DKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGI 241
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKllkrvlkNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 242 SGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIIS 321
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350
....*....|....*....|....*....|..
gi 686343253 322 KRFEHIKGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
6-354 |
1.38e-15 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 77.42 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 6 IRLYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISS 85
Cdd:TIGR00710 5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 86 FICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSF 165
Cdd:TIGR00710 85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 166 LLVISIVLFLIIFFIdIPNVEKGIVKLTEKIEEKYLT----DKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGI 241
Cdd:TIGR00710 165 LSLAGILLSALIFFI-LPETLPYEARIQISTYFETFLlllkSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 242 SGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGF---AMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLAT 318
Cdd:TIGR00710 244 FGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFavsAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMA 323
|
330 340 350
....*....|....*....|....*....|....*.
gi 686343253 319 IISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIIS 354
Cdd:TIGR00710 324 YALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIH 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-355 |
1.21e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.84 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 7 RLYILGFLAFFASL-IQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISS 85
Cdd:COG2223 5 RVLLLATLAFFLAFgVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 86 FICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSF 165
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 166 LLVISIVLFLIIFFI--DIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISG 243
Cdd:COG2223 165 LGILLLVVAVLAWLFlrDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 244 VLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNeSNVIILSVIIFILGTCVGIVPALLATIISKR 323
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGGGNGAVFALVPDI 323
|
330 340 350
....*....|....*....|....*....|...
gi 686343253 324 FE-HIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:COG2223 324 FPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLD 356
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-353 |
4.59e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 69.95 E-value: 4.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 32 LYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQTIGCGII 111
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 112 PLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLgARWDYIGIFSFLLVISIVLFLIIFFIDIPNVEKGIVK 191
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 192 LTEKIEEKY---LTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYN 268
Cdd:cd17329 185 EKTEILRGYkivLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 269 EIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVG--IVPALLATIISKrfeHIKGKVLGVFNFVRYIGMTVG 346
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVfpAVQTLVAALAPP---DKRGSYMGFYALAWGLGRAIG 341
|
....*..
gi 686343253 347 ALLIGII 353
Cdd:cd17329 342 PLVGGLL 348
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
11-353 |
9.69e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 68.76 E-value: 9.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAV 90
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 91 THNFILFAISRLFQTIGCGIIPLmTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVIS 170
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFPL-AFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 171 IVLFLIIFFIDIpnvekgivkltekieeKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGI----SGVLF 246
Cdd:cd17504 160 VLLAALVPLIDL----------------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLgiteAGLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 247 LPITVSVILGSLFYKRFSKKYNEIMILRVTiTGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATII--SKRF 324
Cdd:cd17504 224 LPGALVMLIAGPLAGRLIARVGPRRVLLIG-LVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVveSVPP 302
|
330 340
....*....|....*....|....*....
gi 686343253 325 EHIkGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:cd17504 303 DRT-GIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-287 |
1.67e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.53 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLL 167
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFL 247
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 686343253 248 PITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLF 287
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-353 |
2.42e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 2.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 1 MTKSNIRLYILGFLAF-FASLIQNIYTPIIprLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDS-----IKVL 74
Cdd:COG2211 7 LSLKEKLAYGLGDLGLnLAFGLLSAYLLYF--YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrrRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 75 LTGLGIVIISSFICAVTHN------FILFAISRLFQTIGCGIIPLMTLTLLAKLSTD-NGRAQAMANYQIFLSCAPTLAP 147
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 148 ILGSTLGARWD------YIGIFSFLLVISIVLFLIIFFI--DIPNVEKGIVKLTEKIEEkYLTDKVFITLVTLGFLIFFT 219
Cdd:COG2211 165 VLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGtkERPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 220 YFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILS 299
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 686343253 300 VIIFILGTCVGIVPALLATIIS--------KRFEHIKGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLAdvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
132-357 |
1.39e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 65.33 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 132 MANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEE--KYLTDKVFITL 209
Cdd:cd06173 134 SLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGlrYLRRSPLLRLL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 210 VTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGW 289
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 686343253 290 LneSNVIILSVIIFILGTCVGIVPALLATIISKRF-EHIKGKVLGVFNFVRYIGMTVGALLIGIISQPL 357
Cdd:cd06173 294 S--PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVpDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
20-345 |
2.58e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.42 E-value: 2.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 20 LIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDsiKVLLTGLGIVIISSFICAV--THNFILF 97
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP--RRYLLPLGPLLTGLGLSLLgfAPNYWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 98 AISRLFQTIGCGIIPLMTLTLLAKLSTDNgRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLII 177
Cdd:cd17478 88 LLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 178 FFI--DIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLpITVSVIL 255
Cdd:cd17478 167 LRLrpLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL-FLFAGAI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 256 GSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVII-FILGTCVGIVPALLATIISKRFEHIKGKVLGV 334
Cdd:cd17478 246 GTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAgFLLFASFPVTVVLAQELLPGNVGLASGLMMGL 325
|
330
....*....|.
gi 686343253 335 FNFVRYIGMTV 345
Cdd:cd17478 326 SFGLGGIGAPV 336
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
16-346 |
3.52e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 60.65 E-value: 3.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 16 FFASLIQNIYTPIIPRLYDDF--QVPLFWInatVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHN 93
Cdd:cd17502 6 FLAALDQTIVATALPTIVAEFggLSLVSWV---GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 94 FILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILG----STLGARWdyigIFSFLLVI 169
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGgaftDHLSWRW----CFYINLPI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 170 SIVLFLIIffidipnvekgivkltekieekyltdKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPI 249
Cdd:cd17502 159 GGLALALL--------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 250 TVSVILGSLFYKRFSKK---YNEIMILRVTIT--GFAMFTLLfgwLNESNVIILSVIIFILGTCVGIV-PALLATIISKR 323
Cdd:cd17502 213 IIGLVIGSIISGALISKtgrYKPLIVIGTILMsvGAGLLTTL---TLDTSKWLLIGYLILLGLGLGIGfQQPLVAVQNAV 289
|
330 340
....*....|....*....|...
gi 686343253 324 FEHIKGKVLGVFNFVRYIGMTVG 346
Cdd:cd17502 290 PPADVGVATATNTFFRSLGGTLG 312
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
8-355 |
3.83e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.62 E-value: 3.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFAsliQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLL-TGLGIVIISSF 86
Cdd:cd17490 1 FLIIVFLFWFS---QYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 87 ICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGrAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFL 166
Cdd:cd17490 78 IMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 167 LVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNN-----TYDIGVgI 241
Cdd:cd17490 157 ALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKqlgasSFQLGL-L 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 242 SGVLFLP-ITVSVILGSLFYKRFSKKYneIMILRVTITGFAMFTLLFgwlnESNVIILSVIIFILGTCVGIVPALLATII 320
Cdd:cd17490 236 SIIYLLPnALASLLSGTLFYKKLGERN--TIIIGFLLLGAYCFLIPF----APNLTLLYLLQALNGFGTGILFPLLMSLS 309
|
330 340 350
....*....|....*....|....*....|....*.
gi 686343253 321 SKRF-EHIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17490 310 IEGVpAEQRSTAMGFFQAIYALGMFLGPVLVGIISE 345
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
8-179 |
5.84e-09 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 57.22 E-value: 5.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:PRK11652 10 LFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKL--STDNGRAQAMANYQIFLScaPTLAPILGSTLGARWDYIGIFSF 165
Cdd:PRK11652 90 ALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLyeGTQLRHANSLLNMGILVS--PLLAPLIGGLLTTLFGWRACYLF 167
|
170
....*....|....
gi 686343253 166 LLVISIVLFLIIFF 179
Cdd:PRK11652 168 LLLLGAGVTFSMAR 181
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
73-353 |
1.09e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 57.24 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 73 VLLTGLGIV--IISSFICAVTHNFILFAISRLFQTIGCGIIPlmtlTLLAK--LSTDNGRAQAMANYQIFLSCAptLAPI 148
Cdd:PRK08633 88 VGLTLLIVLayYLGWFWLAFAVTFLLGAQSAIYSPAKYGIIP----ELVGKenLSRANGLLEAFTIVAILAGTA--LFSF 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 149 L-----GSTLGARWDYIGIFSFLLVISIVLFLIIFFiDIPNVEKGIVKLTEKIEE----------KYLTDKVFITLVTLG 213
Cdd:PRK08633 162 LfesvnGNTPSEILGRIAPAGLVLLAVAVLGLIFAY-RLPKVPAAAPEVFDKKKYlfpkllwrnlKLLRSDRVLWLAIIG 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 214 FLIF-----FTYFSILVYLPTLLNNTydiGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFG 288
Cdd:PRK08633 241 LSYFwfisqLAQANFPAYAKEVLGLD---NTFQVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLP 317
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686343253 289 WLneSNVIILSVIIFILGTCVG--IVPaLLATIISKRFEHIKGKVLGVFNFVRYIGMtVGALLIGII 353
Cdd:PRK08633 318 TA--PSLASVLVLFFLFGFSAGlfIVP-LNALIQFRAPEKELGKVLAANNFLQNVGM-LLFLALTTL 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-180 |
3.13e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 3.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 7 RLYILGFLAFFASLIQNIYTPIIP-RLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISS 85
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 86 FICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSF 165
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*
gi 686343253 166 LLVISIVLFLIIFFI 180
Cdd:cd17325 360 AAALLLLAAVLFLLL 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-353 |
3.62e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.94 E-value: 3.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 18 ASLIQNIYTPIIPRLYDDFQVPLFWInATVGGFIFI-VAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFIL 96
Cdd:cd17475 8 ASLVAQGIPALAPFLQEDLHLSLAQV-GLLLSALNLgVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 97 FAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLA----PILGSTLGARWDYIGIFSFLLVISIV 172
Cdd:cd17475 87 LLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAaallPPLALHYGWRAAFVVAGLVSILAAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 173 LFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVS 252
Cdd:cd17475 167 FWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 253 VILGSLFYKRFSKKYNEIMILRV-TITGF--AMFTLLFGWLNESNVIILSVIIFIL-GTCV----GIVPALLATIISKRF 324
Cdd:cd17475 247 GALGRIGLGRVSDRVFGGRRRPVlVITAAiaAAALLVLSLLSPGTPLWLLVLLLILlGLFAigwnGLYLTLVAESAGPEQ 326
|
330 340
....*....|....*....|....*....
gi 686343253 325 EhikGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:cd17475 327 A---GTALGLANTINFIGIAIGPPLFGLL 352
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
16-353 |
5.54e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 54.31 E-value: 5.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 16 FFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFI 95
Cdd:TIGR00711 12 FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 96 LFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFL 175
Cdd:TIGR00711 92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 176 IIFFI---DIPNVEKGI----------------VKLTEKIEEKYLTDKVFITLVTLG----------------------- 213
Cdd:TIGR00711 172 VAFFIlprDKPAASENFdflgllllsvglgsllYGLSEGPERGWFDSNEILILSITGlvaiiafvvweltddnplvdlrl 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 214 -------------FLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGF 280
Cdd:TIGR00711 252 fkyrnftigcvymSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILY 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 686343253 281 AM--FTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATI-ISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:TIGR00711 332 AVgfYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIaLSGLPPHKIARGSSLSNFTRQLGGSIGTALITTI 407
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-357 |
1.37e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.97 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLmTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLL 167
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 168 VISIVLFLIIFFIdipnvekgivkltekieekyltDKVFITLVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFL 247
Cdd:cd17330 160 ALALLNLVLVLFF----------------------LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 248 PITVSVILGSLF-YKRFSKKYNEIMILRvtITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATIISKRFE- 325
Cdd:cd17330 218 LVGIAGILAQLLlIPRLAKRLGERKLLR--LGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPs 295
|
330 340 350
....*....|....*....|....*....|..
gi 686343253 326 HIKGKVLGVFNFVRYIGMTVGALLIGIISQPL 357
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
9-353 |
5.36e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.00 E-value: 5.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 9 YILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVL-LTGLGIVIISSFI 87
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTL--GARWDYIGIFSF 165
Cdd:cd17370 82 LALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlyLLGGNYRTIFLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 166 LLVISIVLFLIIFFIDIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSILVYLptLLNNTYDIGVGISGVL 245
Cdd:cd17370 162 AAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLI--LRAQELGLSAALIPLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 246 FLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCV--GIVPALLATIISKr 323
Cdd:cd17370 240 YALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqeSIERAAVADLVPA- 318
|
330 340 350
....*....|....*....|....*....|
gi 686343253 324 feHIKGKVLGVFNFVRYIGMTVGALLIGII 353
Cdd:cd17370 319 --ELRGTAYGLFNTVVGIGWLLASLIAGYL 346
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
59-354 |
1.14e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 59 IVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIF 138
Cdd:cd17316 54 LLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 139 LSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIDipnvekgivkltekieekyltdKVFITLVTLGFLIFF 218
Cdd:cd17316 134 WALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLR----------------------RRTLLLILLWFFISF 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 219 TYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIIL 298
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL 271
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 686343253 299 SVIIFILGTCVGIVPALLATIISKRF-EHIKGKVLGVFNFVRYIGMTVGALLIGIIS 354
Cdd:cd17316 272 LLLLFILSFFVGGVWGALYAYLAELFpTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-355 |
2.45e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 13 FLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTH 92
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 93 NFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLG-ARWDYIGIFSFLLVISI 171
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGtAGALPFLIAAVLLLLAL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 172 VLFLIIFFIDIPNVEKGIVKLTEKIeekyltdKVFITLVTLGFLIFFTYFSILVYLPTLLNNTyDIGVGISGVLFLPITV 251
Cdd:cd17477 163 VPLLLTRRAAPEIEEAESISLRRLL-------RIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 252 SVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILsVIIFILGTCVGIVPALLATIISKRFEHIK-GK 330
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL-VLLFLWGGAAGPLYTLALALAGDRLPGDElVA 313
|
330 340
....*....|....*....|....*
gi 686343253 331 VLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMD 338
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
8-359 |
4.22e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 48.35 E-value: 4.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAffasliQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFI 87
Cdd:PRK11043 14 LSMLGFLA------TDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 88 CAVTHNFILFAISRLFQTIG-CGiiPLMTLTLLAKLSTDNGRAQamanyQIF--------LScaPTLAPILGSTLGARWD 158
Cdd:PRK11043 88 MLWVESAAQLLVLRFVQAVGvCS--AAVIWQALVIDRYPAQKAN-----RVFatimplvaLS--PALAPLLGAWLLNHFG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 159 YIGIFSFLLVISIVLFLIIFFidIPNVEKGIVKLTEKIEEK-YLTDKVFITLVtlgfLIFFT----YFSILVYLPTLLNN 233
Cdd:PRK11043 159 WQAIFATLFAITLLLILPTLR--LKPSKKARKQSQDALTFKqLLKSKTYLGNV----LIFAAcsaaFFAWLTGSPFILEQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 234 ----TYDIGVGisgvlFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFA---MFTLLFGWLNESNVIILSVIIFILG 306
Cdd:PRK11043 233 mgysPADIGLS-----YVPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAvsvIAIWLASLLSHPSLVPLLIPFCVMA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 686343253 307 TCVG-IVPALLATIISKrFEHIKGKVLGVFNFVRyIGMTVGALLI--GIISQPLVA 359
Cdd:PRK11043 308 AANGaIYPIVVAQALRP-FPQATGKAAALQNTLQ-LGLCFLASLLvsALISTPLLT 361
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-356 |
5.68e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 5.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFasLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAV 90
Cdd:cd17333 3 ISFFSNG--LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 91 THNFILFAISRLFQTIGCGIIPLMTLTLLAKLStDNGRAQAMANYQIFLSCAPTLAPILGSTLGAR-----WDYIGIFSF 165
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSelswsWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 166 LLVISIVLFLIIFFidiPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTY----FSILVYLPTLLNNTYDIGVGI 241
Cdd:cd17333 160 YLLLAILILLTLFP---ELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYvgaeTAFSSWVPSYLVEKKHVSDGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 242 SGVL----FLPITVSVILGSLFYKRFSKKyneimILRVTITGFAMFTLLFGWLNeSNVIILSVIIFILGTCVGIVPALLA 317
Cdd:cd17333 237 AGYLlsgfWVGITIGRLLGGPISRRIKPH-----TLLVLSGSGALLGLLILLLA-PTLVVGLVATALLGLFMAALFPTIL 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 686343253 318 TIISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIISQP 356
Cdd:cd17333 311 SLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
73-354 |
1.27e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 73 VLLTGLGIVIISSFICAVTHNFILFAIsRLFQTIGCGIIPLMTlTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGST 152
Cdd:cd17391 69 LLRASLGMAIVIGLMAFVTNVWQLLIL-RLLQGVFSGYVPNAT-ALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGF 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 153 LGARWDYIGIF---SFLLVISIvlFLIIFFI--DIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLIFFTYFSIL--- 224
Cdd:cd17391 147 LADLFGIRNVFfitGGLLFLAF--LLTLFFVkeDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEpil 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 225 -VYLPTLLNNTYDIGVgISGVLFLPITVSVILGSLFYKRFSKKYNEIMILrvTITGFAMFTLLFGWLNESNVIILSVIIF 303
Cdd:cd17391 225 tLYIRQLMGDASNLAF-ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRIL--LGALLASALLYIPQAFVQTPWQLGILRF 301
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 686343253 304 ILGTCVG-IVPALLATIISKRFEHIKGKVLGVFNFVRYIGMTVGALLIGIIS 354
Cdd:cd17391 302 LLGLATGgLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIA 353
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-353 |
1.38e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.79 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 27 PIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQTI 106
Cdd:COG2807 39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 107 GCGIIPlMTLTLLAKLSTDNGRAQAMANYQIFLSC----APTLAPILGSTLGARWdYIGIFSFLLVISIVLFLIIFFIDI 182
Cdd:COG2807 119 GIAVGN-VLLPGLIKRWFPDRVGLMTGLYTAAMGLgaalAAGLTVPLAAALGWRG-ALAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 183 PNVEKGIVKLTEKieeKYLTDKVFITLVTLGFLIFFTYFSILVYLPTLLNntyDIGV--GISGVLFLPITVSVILGSLFY 260
Cdd:COG2807 197 AAAAAAPAAASLR---SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR---DAGLsaATAGLLLSLFQLAGIPGSLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 261 KRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIfiLGTCVGIVPALLATIISKRFEHIK--GKVLGVFNFV 338
Cdd:COG2807 271 PLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL--LGLGQGGLFPLALTLIGLRARTPAeaAALSGMAQSV 348
|
330
....*....|....*
gi 686343253 339 RYIGMTVGALLIGII 353
Cdd:COG2807 349 GYLLAALGPLLVGAL 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
55-355 |
1.47e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.41 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 55 AVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMAN 134
Cdd:cd17319 52 ALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 135 YQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIdipnvekgivkltekieekyltDKVFITLVTLGF 214
Cdd:cd17319 132 FNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY----------------------LRQVWGLALGYF 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 215 LIFFTYFSILVYLPTLLNNTYDIGVGISGVL----FLPITVSVILGSLFYKRFSKKYNEIMIlrVTITGFAMFTLLFGWL 290
Cdd:cd17319 190 GINYALYGLLTWLPTYLKQARGFSLKQVGLLaaipFLAGAIGMILGGRLSDRLLRGARRLVI--IIGLLLAAVGLLLAYL 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686343253 291 NESN---VIILSVIIFILGTCVGIVPALLATIISKRfehIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17319 268 TTSPvvaVILLSLAGFGIGAASPVFWSLPADLLPGE---AAATAGGLINSGGNLGGFVAPLLIGYLVD 332
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
73-180 |
2.17e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 46.17 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 73 VLLTGLGIVIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGST 152
Cdd:PRK10473 70 VAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHL 149
|
90 100
....*....|....*....|....*...
gi 686343253 153 LGARWDYIGIFSFLLVISIVLFLIIFFI 180
Cdd:PRK10473 150 IMLKFPWQSLFYTMAAMGILVLLLSLFI 177
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
204-355 |
6.12e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 204 KVFITLVTLGFLIFFTYFSILVYLPTLLNnTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMF 283
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 686343253 284 TLLFGWLNesNVIILSVIIFILGTCVGIVPALLATIISKRF-EHIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:COG2814 89 SLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
47-355 |
2.59e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 47 VGGFIFIVAVMQIV----LGRSIDSR-DSIKVLLTGLGIVIISSFICAVTHNFI-LFAISRLFQTIGCGIIPLMTLTLLA 120
Cdd:cd17471 34 IGIFMTLSALSGIVvsqwLGRLSDRGgDRKPLILLALLAGALGYLLFAFLRNYWvLLLVGVVLLSLGAAAFPQLFALARE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 121 KLSTDNGRAQAMANYQI--FLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFIdIPNVEKGIVKLTEKIEE 198
Cdd:cd17471 114 YADRSSGRDATLFNSVLraAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFL-LPSVKPPAQKATPASSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 199 KYLTDKVFITLVTLGFLIFFTYFSI-LVYLPTLLNNTYDIGVGISGVLF-------LPITvsvILGSLFYKRFSKKynei 270
Cdd:cd17471 193 VKAPVNRRLLLLFAAFTLLFAANSMyIIAMPLYVTNELGGSESWVGLLFglaaaleIPIM---LLAGLLAKRFGKR---- 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 271 milRVTITGFAMFTLLF-GWLNESNVIILSVIIFILGTCVGIVPALLATIISKRFEHIKGKVLGVFNFVRYIGMTVGALL 349
Cdd:cd17471 266 ---RLLLAGFLAGVLFYlGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLL 342
|
....*.
gi 686343253 350 IGIISQ 355
Cdd:cd17471 343 AGVIAQ 348
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
9-180 |
4.25e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.26 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 9 YILGFLAFFASLIQNIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFIC 88
Cdd:pfam00083 14 YDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 89 AVTH---NFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILG---STLGARWDYIGI 162
Cdd:pfam00083 94 GAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIP 173
|
170
....*....|....*...
gi 686343253 163 FSFLLVISIVLFLIIFFI 180
Cdd:pfam00083 174 LGLQLVPALLLIIGLLFL 191
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
25-180 |
8.33e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.05 E-value: 8.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 25 YTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQ 104
Cdd:PRK11102 10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 686343253 105 TIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFI 180
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFF 165
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-355 |
1.99e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.98 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 24 IYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLF 103
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 104 QTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSC----APTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFF 179
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 180 I----------DIPNVEKGIVKLTEKIEEKYLTDKVFITLVTLGFLifFTYFSILVYLPTLLNNTYDIGV-GISGVLFLP 248
Cdd:cd17371 177 VkeppqwqaarAARRHFADRPSLRELFSPPLLRTTLLASLLATGAL--GGYYGITTWLPSYLTGERGLSFeGSAGYLVVT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 249 ITVSvILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILsVIIFILGTCVGIVPALLATIISKRF-EHI 327
Cdd:cd17371 255 ILGG-FLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLIL-ILGFPLGFFASGPFSGMGAYLTELFpTAV 332
|
330 340
....*....|....*....|....*....
gi 686343253 328 KGKVLGV-FNFVRYIGmTVGALLIGIISQ 355
Cdd:cd17371 333 RATAQGFcYNVGRIIG-ALFPFLVGFLAT 360
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
209-355 |
2.30e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 209 LVTLGFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFG 288
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686343253 289 WLneSNVIILSVIIFILGTCVGIVPALLATIISKRF-EHIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:pfam07690 81 FA--SSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLAS 146
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
73-179 |
2.34e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.56 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 73 VLLTGLGIvIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTlTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGST 152
Cdd:cd17389 97 LLLTMIGL-AISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAY 174
|
90 100 110
....*....|....*....|....*....|...
gi 686343253 153 LGARWDYIGIFSFL------LVISIVLFLIIFF 179
Cdd:cd17389 175 FASFTRSLGEVFFSmpalfaLVLALADLLFIFF 207
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
49-320 |
2.47e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.53 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 49 GFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGR 128
Cdd:cd17328 42 VFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 129 AQAMANYQIFLSCAPTLAPILGS-----TLGARWDYI--GIFSFLLVIsivlfLIIFFIDIP--NVEKGIVKLTEKIEE- 198
Cdd:cd17328 122 TRALGVFYFAIPLGSGLGYVVGGlvaqaTGGWRWAFRvtGVLGVLLAI-----LLLLFVREPprGAAEGGVMAKSTATSf 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 199 ----KYLTDKVFITLVTLGFLIF-FTYFSILVYLPTLLNNTYDIGV---GISGVLFLPIT-----VSVILGSLFYKRFSK 265
Cdd:cd17328 197 ladlKALAKNPSFILSTLGFTAVsFVTGALAFWAPTFFLRAFGVGDlssADVGLIFGAITciagvLGVLLGGILADRLRR 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 686343253 266 KYN--EIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGIVPALLATII 320
Cdd:cd17328 277 KTPraDPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAIL 333
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
53-181 |
3.25e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 53 IVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSFICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAM 132
Cdd:cd17329 248 LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYM 327
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 686343253 133 ANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLVISIVLFLIIFFID 181
Cdd:cd17329 328 GFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
7-178 |
4.19e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.07 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 7 RLYILGFLAFFASLIqnIYTPIIPRLYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDSIKVLLTGLGIVIISSF 86
Cdd:cd17324 202 LAYLITFLLFGGFFA--LYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 87 ICAVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNgRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFL 166
Cdd:cd17324 280 LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
170
....*....|..
gi 686343253 167 LVISIVLFLIIF 178
Cdd:cd17324 359 AALLLLALLLAL 370
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
213-357 |
4.29e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 38.96 E-value: 4.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 213 GFLIFFTYFSILVYLPTLLNNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLne 292
Cdd:pfam05977 227 AFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALA-- 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686343253 293 SNVIILSVIIFILGTCVGIVPALL---ATIISKRFehIKGKVLGVFNFVRYIGMTVGALLIGIISQPL 357
Cdd:pfam05977 305 PNLWLAIPVLLLGGAAWITALTTLnvaVQLSVPRW--VRGRALAVYQTVFFGGMAAGSWLWGAVAEAL 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
11-179 |
6.85e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 6.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 11 LGFLAFFASLIQNIYTPIIPR-LYDDFQVPLFWINATVGGFIFIVAVMQIVLGRSIDSRDS-IKVLLTGLGIVIISSFIC 88
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLfLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGeRKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 89 AVTHNFILFAISRLFQTIGCGIIPLMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLGARWDYIGIFSFLLV 168
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
170
....*....|.
gi 686343253 169 ISIVLFLIIFF 179
Cdd:cd17330 339 LLLIALFLLSL 349
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
8-355 |
9.37e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 37.59 E-value: 9.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 8 LYILGFLAFFA-SLIqniyTPIIPRLYDDFQvplfwINATVGGFIFIV-AVMQI----VLGRSIDSRDSIKVLLTGLGIV 81
Cdd:cd17390 1 LYLVGFLDLFGvSMI----LPLLSTHIRSLG-----ASPTVIGLIGSVyGALQLfsspLVGSWSDVVGRRPVLLICLLLT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 82 IISSFICAVTHNFILFAISRlfqtIGCGIIP---LMTLTLLAKLSTDNGRAQAMANYQIFLSCAPTLAPILGSTLgARWD 158
Cdd:cd17390 72 ALGYVLLGFSTSLALLFLSR----IPLGIFKhtqSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL-AETD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 159 -------YIGIFSFLLVISIVLFLIIFFIDIPnvekgIVKLtekieekyltdkvfitLVTLGFLIFFTYFSIlvylptLL 231
Cdd:cd17390 147 ggfyyvaLLCSAIFILNAGLVWFLLSKLWDLL-----LVRF----------------LMGFSVLLFRSNFSL------YL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686343253 232 NNTYDIGVGISGVLFLPITVSVILGSLFYKRFSKKYNEIMILRVTITGFAMFTLLFGWLNESNVIILSVIIFILGTCVGI 311
Cdd:cd17390 200 EERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAV 279
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 686343253 312 VPALLATIISKRFE-HIKGKVLGVFNFVRYIGMTVGALLIGIISQ 355
Cdd:cd17390 280 LRTCSTSLLLSRGKsKERGTLLGVGQSVTSLARILAPLLSGLLQE 324
|
|
| |
