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Conserved domains on  [gi|685318504|ref|WP_031617330|]
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GTP-binding protein, partial [Salmonella enterica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YejR super family cl33931
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 1-92 1.00e-28

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


The actual alignment was detected with superfamily member COG0523:

Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 104.48  E-value: 1.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504   1 NTLLRQGKPDRLLIEPTGLGHPKQILDMLTSE-VYEPYIDLRATLCLLDPRQLLD--EKYVTNENFRDQLAAADIIVANK 77
Cdd:COG0523   78 RRLLRRGRFDRLLIETTGLADPAPVAQTFTFDpELRDRLRLDGVVTVVDARNLLDdlADRTLHELLVDQIAFADVIVLNK 157

                         90
                 ....*....|....*
gi 685318504  78 QDRSDAASLAALNAW 92
Cdd:COG0523  158 TDLVDEEELAALEAR 172
 
Name Accession Description Interval E-value
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 1-92 1.00e-28

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 104.48  E-value: 1.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504   1 NTLLRQGKPDRLLIEPTGLGHPKQILDMLTSE-VYEPYIDLRATLCLLDPRQLLD--EKYVTNENFRDQLAAADIIVANK 77
Cdd:COG0523   78 RRLLRRGRFDRLLIETTGLADPAPVAQTFTFDpELRDRLRLDGVVTVVDARNLLDdlADRTLHELLVDQIAFADVIVLNK 157

                         90
                 ....*....|....*
gi 685318504  78 QDRSDAASLAALNAW 92
Cdd:COG0523  158 TDLVDEEELAALEAR 172
CobW-like cd03112
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ...
 3-92 5.12e-22

cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.


Pssm-ID: 349766  Cd Length: 198  Bit Score: 84.50  E-value: 5.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504   3 LLRQGKPDRLLIEPTGLGHPKQILDMLTSEVY-EPYIDLRATLCLLDPRQLLDEKY--VTNENFRDQLAAADIIVANKQD 79
Cdd:cd03112   79 LERRGKFDYILIETTGLADPGPIAQTLWSDEElESRLRLDGVVTVVDAKNFLKQLDeeDVSDLAVDQIAFADVIVLNKTD 158

                         90
                 ....*....|...
gi 685318504  80 RSDAASLAALNAW 92
Cdd:cd03112  159 LVDEEELEALRAR 171
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 3-92 1.66e-19

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 77.68  E-value: 1.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504    3 LLRQGKPDRLLIEPTGLGHPKQILDMLTSEVYEPYIDLRATLCLLDPRQlLDEKYVTNENFRDQLAAADIIVANKQDR-S 81
Cdd:pfam02492  78 LEREGRLDVIFIETTGLAEPAPVAQTFLSPELRSPVLLDGVITVVDAAN-EADGEKIPRKAGDQIAFADLIVLNKTDLaP 156

                          90
                  ....*....|.
gi 685318504   82 DAASLAALNAW 92
Cdd:pfam02492 157 EVALLEVLEED 167
 
Name Accession Description Interval E-value
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 1-92 1.00e-28

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 104.48  E-value: 1.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504   1 NTLLRQGKPDRLLIEPTGLGHPKQILDMLTSE-VYEPYIDLRATLCLLDPRQLLD--EKYVTNENFRDQLAAADIIVANK 77
Cdd:COG0523   78 RRLLRRGRFDRLLIETTGLADPAPVAQTFTFDpELRDRLRLDGVVTVVDARNLLDdlADRTLHELLVDQIAFADVIVLNK 157

                         90
                 ....*....|....*
gi 685318504  78 QDRSDAASLAALNAW 92
Cdd:COG0523  158 TDLVDEEELAALEAR 172
CobW-like cd03112
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ...
 3-92 5.12e-22

cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.


Pssm-ID: 349766  Cd Length: 198  Bit Score: 84.50  E-value: 5.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504   3 LLRQGKPDRLLIEPTGLGHPKQILDMLTSEVY-EPYIDLRATLCLLDPRQLLDEKY--VTNENFRDQLAAADIIVANKQD 79
Cdd:cd03112   79 LERRGKFDYILIETTGLADPGPIAQTLWSDEElESRLRLDGVVTVVDAKNFLKQLDeeDVSDLAVDQIAFADVIVLNKTD 158

                         90
                 ....*....|...
gi 685318504  80 RSDAASLAALNAW 92
Cdd:cd03112  159 LVDEEELEALRAR 171
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 3-92 1.66e-19

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 77.68  E-value: 1.66e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685318504    3 LLRQGKPDRLLIEPTGLGHPKQILDMLTSEVYEPYIDLRATLCLLDPRQlLDEKYVTNENFRDQLAAADIIVANKQDR-S 81
Cdd:pfam02492  78 LEREGRLDVIFIETTGLAEPAPVAQTFLSPELRSPVLLDGVITVVDAAN-EADGEKIPRKAGDQIAFADLIVLNKTDLaP 156

                          90
                  ....*....|.
gi 685318504   82 DAASLAALNAW 92
Cdd:pfam02492 157 EVALLEVLEED 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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