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Conserved domains on  [gi|658549669|ref|WP_029742056|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Enterobacter]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-97 1.13e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 86.10  E-value: 1.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658549669  1 MTELEQLQasagQAATLLKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYS 80
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*..
gi 658549669 81 IKNDAVHQLISTLKTLY 97
Cdd:COG0640  76 LADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-97 1.13e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 86.10  E-value: 1.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658549669  1 MTELEQLQasagQAATLLKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYS 80
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*..
gi 658549669 81 IKNDAVHQLISTLKTLY 97
Cdd:COG0640  76 LADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 5.88e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 81.35  E-value: 5.88e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658549669 14 AATLLKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIKNDAVHQLI 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 5.08e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.08  E-value: 5.08e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658549669   29 ILCTLCGAPGTsAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIKNDAVHQLISTL 93
Cdd:smart00418  2 ILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-96 6.60e-16

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 66.17  E-value: 6.60e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658549669 18 LKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIknDAVHQLISTLKTL 96
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL--TDAERLLALLESL 76
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 9.27e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.06  E-value: 9.27e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 658549669  23 NPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 18-81 1.13e-07

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 45.10  E-value: 1.13e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658549669 18 LKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSI 81
Cdd:NF033789  2 FKALSDPTRREILELLKEGD-MTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 25-70 4.52e-06

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 42.73  E-value: 4.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 658549669   25 RRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDS 70
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
1-97 1.13e-23

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 86.10  E-value: 1.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658549669  1 MTELEQLQasagQAATLLKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYS 80
Cdd:COG0640   1 MSETKELE----ELAELFKALADPTRLRILRLLAEGE-LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYR 75

                        90
                ....*....|....*..
gi 658549669 81 IKNDAVHQLISTLKTLY 97
Cdd:COG0640  76 LADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-90 5.88e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 81.35  E-value: 5.88e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658549669 14 AATLLKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIKNDAVHQLI 90
Cdd:NF033788  1 LAELFKALADPTRLRILELLAEGE-LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
29-93 5.08e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.08  E-value: 5.08e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658549669   29 ILCTLCGAPGTsAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIKNDAVHQLISTL 93
Cdd:smart00418  2 ILKLLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-96 6.60e-16

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 66.17  E-value: 6.60e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658549669 18 LKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIknDAVHQLISTLKTL 96
Cdd:cd00090   1 LKALSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL--TDAERLLALLESL 76
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
1-85 3.84e-14

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 63.74  E-value: 3.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658549669   1 MTELEQlqasagqaaTLLKAMSN--PRRllILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRIL 78
Cdd:COG3398   83 YSEEEK---------KILAYLRRetPRR--ILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVR 151


                 ....*..
gi 658549669  79 YSIKNDA 85
Cdd:COG3398  152 YYLNPPE 158
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
9-91 1.90e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 58.12  E-value: 1.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658549669   9 ASAGQAATLLKAMSNPRRLLILCTLCGAPGTsAGELARATGLSPSATSQHLARMREEGLIDSTRD-----AQRILYSIKN 83
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSEEPAY-VSELARELGVSRQAVYKHLRKLEEAGLVESYREgredgRARKYYRLSA 80


                 ....*...
gi 658549669  84 DAVHQLIS 91
Cdd:COG1777   81 FRLEVTLT 88
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-68 9.27e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 52.06  E-value: 9.27e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 658549669  23 NPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLI 68
Cdd:pfam01022  1 DPTRLKILKLLAEGE-LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
14-89 1.73e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 50.34  E-value: 1.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658549669 14 AATLLKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDST-----RDAQRILYSIKNDAVHQ 88
Cdd:COG4189   9 SLEVLKALASETRLRILRLLAEEP-LNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEykpgkRGRQKICYLRVDKILIV 87


                .
gi 658549669 89 L 89
Cdd:COG4189  88 L 88
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-73 6.10e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 47.92  E-value: 6.10e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 658549669  15 ATLLKAMSNPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRD 73
Cdd:pfam12840  1 DDVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVRE 59
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-75 7.87e-08

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 46.89  E-value: 7.87e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 658549669  23 NPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQ 75
Cdd:COG1846   37 TPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-74 8.01e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 44.89  E-value: 8.01e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 658549669  23 NPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRDA 74
Cdd:pfam12802  4 TPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSP 55
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
26-68 8.65e-08

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 44.35  E-value: 8.65e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 658549669  26 RLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLI 68
Cdd:pfam13412  3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 18-81 1.13e-07

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 45.10  E-value: 1.13e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658549669 18 LKAMSNPRRLLILCTLCGAPgTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSI 81
Cdd:NF033789  2 FKALSDPTRREILELLKEGD-MTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
19-79 3.95e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 45.25  E-value: 3.95e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658549669  19 KAMSNPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILY 79
Cdd:COG3398   16 NVLDNDTRRRIYEYIRENPGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRY 76
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 43-84 1.16e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.59  E-value: 1.16e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 658549669 43 ELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIKND 84
Cdd:COG2512  35 EIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPED 76
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
15-72 1.57e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 44.14  E-value: 1.57e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 658549669  15 ATLLKAMSNPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTR 72
Cdd:COG2345    4 TPALAALADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
23-79 1.79e-06

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.58  E-value: 1.79e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 658549669    23 NPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRDA--QRILY 79
Cdd:smart00347   9 TPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPedRRSVL 67
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 25-70 4.52e-06

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 42.73  E-value: 4.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 658549669   25 RRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDS 70
Cdd:TIGR01884 144 EELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ 189
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 23-73 9.51e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 37.14  E-value: 9.51e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 658549669  23 NPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRD 73
Cdd:pfam01047  2 TLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRS 52
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 18-70 1.07e-04

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 38.90  E-value: 1.07e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 658549669  18 LKAMSNPRRLLILCTLcGAPGT-SAGELARATGLSPSATSQHLARMREEGLIDS 70
Cdd:cd09655  133 LLAGLSREELKILEVL-KAKGEkSVKNIAKKLGKSLSTISRHLRELEKKGLVEQ 185
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
39-68 2.04e-04

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 37.45  E-value: 2.04e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 658549669  39 TSAGELARATGLSPSATSQHLARMREEGLI 68
Cdd:COG1522   20 LSFAELAERVGLSESTVLRRVRRLEEAGVI 49
COG4190 COG4190
Predicted transcriptional regulator, contains HTH domain [Transcription];
14-87 2.39e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443344  Cd Length: 121  Bit Score: 37.18  E-value: 2.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658549669  14 AATLLKAMSnPRRLLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLIDSTRDAQRILYSIKNDAVH 87
Cdd:COG4190   43 PESLARVLT-PKRLELLRAIAEEGPESIRELARRLGRDVKNVHRDLKTLEELGLVELEEDGRAKRPVVPYDEIE 115
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
43-77 1.27e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 33.95  E-value: 1.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 658549669   43 ELARATGLSPSATSQHLARMREEGLIdsTRDAQRI 77
Cdd:smart00419 13 EIAELLGLTRETVSRTLKRLEKEGLI--SREGGRI 45
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 43-68 1.63e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 34.18  E-value: 1.63e-03
                        10        20
                ....*....|....*....|....*.
gi 658549669 43 ELARATGLSPSATSQHLARMREEGLI 68
Cdd:cd00092  30 EIADYLGLTRETVSRTLKELEEEGLI 55
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 27-68 2.51e-03

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 34.41  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 658549669    27 LLILCTLCGAPGTSAGELARATGLSPSATSQHLARMREEGLI 68
Cdd:smart00344   6 RKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVI 47
DmsR COG3413
Predicted transcriptional regulator, contains HTH domain [General function prediction only];
38-71 6.01e-03

Predicted transcriptional regulator, contains HTH domain [General function prediction only];


Pssm-ID: 442639 [Multi-domain]  Cd Length: 143  Bit Score: 33.76  E-value: 6.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 658549669  38 GTSAGELARATGLSPSATSQHLARMrEEGLIDST 71
Cdd:COG3413  108 EATLEELAEELGISKSTLSEHLRRA-ERKLLEAL 140
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
26-72 6.02e-03

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 33.66  E-value: 6.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 658549669  26 RLLILCTLCGAPG-TSAGELARATGLSPSATSQHLARMREEGLIDSTR 72
Cdd:COG1959   11 RALLYLALHPGGEpVTSKEIAERQGISPSYLEKILQKLRKAGLVESVR 58
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
35-81 6.58e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 34.02  E-value: 6.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 658549669  35 GAPGTSAGELARATGLSPSATSQHLARMREEGLIDstRDAQRILYSI 81
Cdd:COG1414   21 AGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVE--RDPEGGRYRL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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