|
Name |
Accession |
Description |
Interval |
E-value |
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
2-456 |
7.38e-149 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 433.30 E-value: 7.38e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 2 TSINDSTLMPAALRDTRRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHF--------TLSNRLQEWVVSSMMLGAAI 73
Cdd:TIGR00879 7 ADASELLVTPAGLGSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 74 GALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAAN---VEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMIS 150
Cdd:TIGR00879 87 GALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 151 MYQLMVTLGIVLAFLSDT---YFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKA 227
Cdd:TIGR00879 167 LYQLAITFGILVAYGFGSgkvSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGED 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 228 REELNE-----IRESLKLKQG---GWALFKINRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTtEQQMIAT 299
Cdd:TIGR00879 247 KELLDElelidIKRSIEKRSVqpsWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVST-DHAFLVS 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 300 LVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNGtASSGLSWLSVGMTMMCIAGYAMSAAPVV 379
Cdd:TIGR00879 326 IIVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASFVTG-SSKSSGNVAIVFILLFIAFFAMGWGPVP 404
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 380 WILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHI 456
Cdd:TIGR00879 405 WVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
24-458 |
1.03e-135 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 398.57 E-value: 1.03e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 24 VSIAAAVAGLLFGLDIGVIAGALPFI--TDHFTLSNR---------LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLM 92
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIdfFKNFGLSKSvsslaalsvLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 93 VGAILFVAGSIGSAFA---ANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTY 169
Cdd:pfam00083 81 IANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 170 FSYSGN---WRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEkAREELNEIRESLKLKQGG-- 244
Cdd:pfam00083 161 LNKTSNsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPD-VDRELDEIKDSLEAGQEAek 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 245 --WALFKINRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeqqMIATLVVGLTFMFATFIAVFTVDKAGR 322
Cdd:pfam00083 240 asWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 323 KPALKIGFSVMAIGTLILGYClmqFDNGTA-SSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTT 401
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIV---ALLGVSkSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATA 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 402 TNWVSNMIIGATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHIER 458
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDE 450
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
27-447 |
1.37e-120 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 356.88 E-value: 1.37e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 27 AAAVAGLLFGLDIGVIAGALPFITD--HFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIG 104
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKdlGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 105 SAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYS--GNWRAMLGV 182
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSppGWWRLMFAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 183 LALPALVLIVLVIFLPNSprwlaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfkinrnvrRAVFLGM 262
Cdd:cd17315 161 AAVPALLQLLLMFFLPES-------------------------------------------------------RALLVGV 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 263 LLQAMQQFTGMNIIMYYAPRIFKMAGftTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGY 342
Cdd:cd17315 186 GLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAI 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 343 CLMqfdNGTASSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIG 422
Cdd:cd17315 264 AFL---LPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIG 340
|
410 420
....*....|....*....|....*
gi 658548708 423 AAGTFWLYTVLNVAFIGVTFWLIPE 447
Cdd:cd17315 341 LAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
23-447 |
1.18e-107 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 324.52 E-value: 1.18e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 23 FVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGS 102
Cdd:cd17359 1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 103 IGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGN------- 175
Cdd:cd17359 81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGadwlgae 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 176 -WRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGrhveaeevlrmlrdtsekareelneireslklkqggwalfkinrnv 254
Cdd:cd17359 161 gWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG---------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 255 RRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMA 334
Cdd:cd17359 195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGF-SENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMA 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 335 IGTLILGYClMQFDNGTASSGlsWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATF 414
Cdd:cd17359 274 ISLLLIGTA-FYFAPGSQASG--IVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTF 350
|
410 420 430
....*....|....*....|....*....|....
gi 658548708 415 LTLLDAIGAAGTFWLYTVLNV-AFIGVTFWLiPE 447
Cdd:cd17359 351 PILLAAFGLAFTFLIFAVICVlAFLFVWKFV-PE 383
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
23-455 |
3.13e-94 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 291.79 E-value: 3.13e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 23 FVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQE----WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILF 98
Cdd:cd17358 2 LATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVaqfsWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 99 VAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFsysgNWRA 178
Cdd:cd17358 82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 179 MLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAREELNEIRESLK-----LKQGGWALFKiNRN 253
Cdd:cd17358 158 LALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAelekeAKESSFSDLF-QRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 254 VRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVM 333
Cdd:cd17358 237 YLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPN--TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGM 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 334 AIGTLILG-YCLMQFDNGTASSgLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGA 412
Cdd:cd17358 315 GIGLLALGlYFYLQEHGALLSS-VSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTK 393
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 658548708 413 TFLTLLDAIGAAGTFWLYTVLN-VAFIGVTFWLiPETKGVTLEH 455
Cdd:cd17358 394 TFPFLTLAWGASGTFWIFAGICgLALVFVLLFV-PETKGKSLEE 436
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
27-447 |
1.60e-91 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 282.24 E-value: 1.60e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 27 AAAVAGLLFGLDIGVIAGALPFITDHF---TLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSI 103
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 104 GSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSY-SGNWRAMLGV 182
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYlPGGWRWMLGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 183 LALPALVLIVLVIFLPNSPRWlaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfkinRNVRRAVFLGM 262
Cdd:cd17360 161 AAVPAVLQFIGLLFLPESPRW------------------------------------------------PSTRRALIVGC 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 263 LLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGy 342
Cdd:cd17360 193 GLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVVLA- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 343 clmqfdngtassglSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIG 422
Cdd:cd17360 272 --------------VWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIG 337
|
410 420
....*....|....*....|....*.
gi 658548708 423 AAGTFWLYTVLNV-AFIGVTFWLiPE 447
Cdd:cd17360 338 PYGTFLLFAGLAVlGLIFIYFCV-PE 362
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
28-456 |
3.58e-84 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 264.21 E-value: 3.58e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 28 AAVAGLLFGLDIGVIAGALPFI-------TDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVA 100
Cdd:cd17362 2 PALGGLLFGYDIGATSGALLSItspalsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 101 GSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYF-SYSGNWRAM 179
Cdd:cd17362 82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFaDVVGGWRYM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 180 LGVLALPALVLIVLVIFLPNSPRWlaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfkiNRNVRRAVF 259
Cdd:cd17362 162 YGLAAPPALLLGIGMWFLPPSPRW-----------------------------------------------QGNYRKPLI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 260 LGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLI 339
Cdd:cd17362 195 IGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMVVSLFL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 340 LGYCLMQFDNGTAssGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLD 419
Cdd:cd17362 275 LAAYNLFVQMGPA--GLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQE 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 658548708 420 AIGAAGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHI 456
Cdd:cd17362 353 LIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
23-458 |
2.06e-80 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 257.31 E-value: 2.06e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 23 FVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQE--------WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVG 94
Cdd:PRK10077 12 SITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSEsaansllgFCVASALIGCIIGGALGGYCSNRFGRRDSLKIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 95 AILFVAGSIGSAF---------AANVEILL---LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL 162
Cdd:PRK10077 92 AVLFFISALGSAWpefgftsigPDNTGYVPefvIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 163 AFLSDTYFSYSGN--------WRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTsEKAREELNEI 234
Cdd:PRK10077 172 VYFVNYFIARSGDaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN-TLATQALQEI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 235 RESLKLKQ-GGWALFKINRNVrraVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGfTTTEQQMIATLVVGLTFMFATFIA 313
Cdd:PRK10077 251 KHSLDHGRkTGGKLLMFGVGV---IVIGVMLSVFQQFVGINVVLYYAPEIFKTLG-ASTDIALLQTIIVGVINLTFTVLA 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 314 VFTVDKAGRKPALKIGFSVMAIGTLILGYCLmqfdnGTASSGLswLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRD 393
Cdd:PRK10077 327 IMTVDKFGRKPLQIIGALGMAIGMFSLGTAF-----YTQAPGI--VALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRG 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658548708 394 FGITCSTTTNWVSNMIIGATF------LTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHIER 458
Cdd:PRK10077 400 KALAIAVAAQWIANYFVSWTFpmmdknSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEA 470
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
25-454 |
5.14e-73 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 236.31 E-value: 5.14e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 25 SIAAAVAGLLFGLDIGVIAGALPFITD----HFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVA 100
Cdd:cd17433 4 TFAAVLGPLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 101 GSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYsgNWRAML 180
Cdd:cd17433 84 GFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDW--RWLAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 181 GvlALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGWALFKI-NRNVRRAVF 259
Cdd:cd17433 162 G--SIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLALLkQPGIYKPLI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 260 LGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEqqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLI 339
Cdd:cd17433 240 IGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS---VASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGVVMVFSTAA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 340 LGyclmqfdngtassglsWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLD 419
Cdd:cd17433 317 FG----------------WLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLME 380
|
410 420 430
....*....|....*....|....*....|....*
gi 658548708 420 AIGAAGTFWLYTVLNVAFIGVTFWLIPETKGVTLE 454
Cdd:cd17433 381 VLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
23-458 |
2.06e-69 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 226.36 E-value: 2.06e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 23 FVSIAAAVAGLLFGLDIGVIAGAL---------PFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMV 93
Cdd:cd17356 1 LLCAFVSLGGFLFGYDTGSISGILnmksfqkyfADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 94 GAILFVAGSIGSAFAANVEI-LLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSY 172
Cdd:cd17356 81 GCVIYIIGAIIQVAAIGKWYqLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 173 SGN---WRAMLGVLALPALVLIVLVIFLPNSPRWLaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfk 249
Cdd:cd17356 161 LDGsaqWRIPLGLQIVWGLLLLIGMFFLPESPRWL--------------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 250 inrnvrRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEqQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIG 329
Cdd:cd17356 196 ------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSS-PLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIG 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 330 FSVMAIGTLILGYCLMQFDNGTASSGLSWLSVGMTMMC-----IAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNW 404
Cdd:cd17356 269 AAGMSICLFIYAAVGVRYLIPNPQSGTSNKSAGNGMIVficlfIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNW 348
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 658548708 405 VSNMIIGATFLTLLDAIGaAGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHIER 458
Cdd:cd17356 349 LWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDE 401
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
26-450 |
4.01e-66 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 219.06 E-value: 4.01e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGA----LPFITDHFTLSNRLQ--------EW--VVSSMMLGAAIGALFNGWLSFRLGRKYSL 91
Cdd:cd17357 3 IVAFGGSFQFGYNIGVVNAPqevfKEFINDTLVDRYGLNlsdseldlLWslIVSIFFIGGAIGSFISAFLANRFGRKNGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 92 MVGAILFVAGSI---GSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--FLS 166
Cdd:cd17357 83 LISNALLVVSSLlmfLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGqvFGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 167 DTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWLA-QKGRHVEAEEVLRMLRDTSEKAREELNEIR-ESLKLKQGG 244
Cdd:cd17357 163 PSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLiSKGDEEEAEKSLKFLRGIEDDVDQELEEIKkESEQMGDQK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 245 ----WALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEQQMIATLVVGLTFMFATFIAVFTVDKA 320
Cdd:cd17357 243 qvslMQLLR-DPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGF-SPQLAEWANLGIGIVNVLSTIVGPFLIEKV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 321 GRKPALKIGFSVMAIGTLILGYCLMQFDNgtaSSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCST 400
Cdd:cd17357 321 GRRPLLLISLSVCAVALLLMSVFLFLSEQ---NSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGS 397
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 658548708 401 TTNWVSNMIIGATFLTLLDAIGAAgTFWLYTVLNVAFIGVTFWLIPETKG 450
Cdd:cd17357 398 SVNWTSNFIVGMAFPPLQSIGGGF-VFIIFAIPCALFLLYLYRYLPETKG 446
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
28-456 |
2.86e-65 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 215.34 E-value: 2.86e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 28 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAF 107
Cdd:cd17437 2 ASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 108 AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFS---YSGNWRAMLGVLA 184
Cdd:cd17437 82 APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSglpLHVGWRLMLGVGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 185 LPALVLIVLVIFLPNSPRWlaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfkiNRNVRRAVFLGMLL 264
Cdd:cd17437 162 VPSLFLAIGVLAMPESPRW-----------------------------------------------TPAVRRMLIAALGI 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 265 QAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCL 344
Cdd:cd17437 195 HFFQQASGIDAVVLYSPRIFKKAGIKSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 345 MQFDNGTASSGL-SWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA 423
Cdd:cd17437 275 TFIDRNGGGLTWaLVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITT 354
|
410 420 430
....*....|....*....|....*....|...
gi 658548708 424 AGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHI 456
Cdd:cd17437 355 GGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
25-456 |
1.28e-59 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 200.02 E-value: 1.28e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 25 SIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIG 104
Cdd:cd17435 3 SVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 105 SAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYF-SYSGNWRAMLGVL 183
Cdd:cd17435 83 LVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFaNVSNGWKYMFGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 184 ALPALVLIVLVIFLPNSPRWLAQKGrhveaeevlrmlrdtsekareelneireslklkqggwalfkinrNVRRAVFLGML 263
Cdd:cd17435 163 IPLAALQAIAMYFLPPSPRFLVMKD--------------------------------------------NMRARLLIGLT 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 264 LQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGyc 343
Cdd:cd17435 199 LVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMG-- 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 344 lmqfdngtassglSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA 423
Cdd:cd17435 277 -------------LWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTELIGL 343
|
410 420 430
....*....|....*....|....*....|...
gi 658548708 424 AGTFWLYTVLNVAFIGVTFWLIPETKGVTLEHI 456
Cdd:cd17435 344 PWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
23-450 |
2.48e-58 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 198.71 E-value: 2.48e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 23 FVSIAAAVAGLLFGLDIGVIAGALPFITDHF--TLSNRLQE----------WVVSSMM--LGAAIGALFNGWLSFRLGRK 88
Cdd:cd17431 1 FAVFVAVLGSLQFGYNTGVINAPQKVIEEFYnkTLGDRYGEpispetlttlWSLSVAIfsVGGMIGSFSVGLFVNRFGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 89 YSLMVGAILFVAGSIGSAF---AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-- 163
Cdd:cd17431 81 NSMLYNNLLAFAGAALMGLsklAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISqi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 164 FLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWL-AQKGRHVEAEEVLRMLR---DTSEKAREELNEIRESLK 239
Cdd:cd17431 161 FGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRgttDVSEDIQEMKEESRQMMR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 240 LKQGGW-ALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGfttTEQQMIATLVVGLTFMFATFIAVFTVD 318
Cdd:cd17431 241 EKKVTIlELFR-SSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAG---VQQPVYATIGAGVVNTIFTVVSLFLVE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 319 KAGRKPALKIGFSVMAIGTLILGYCLMQFDNgtaSSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITC 398
Cdd:cd17431 317 RAGRRTLHLIGLGGMAICAILMTIALLLLEG---YPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAV 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 658548708 399 STTTNWVSNMIIGATFLTLLDAIGAAgTFWLYTVLNVAFIGVTFWLIPETKG 450
Cdd:cd17431 394 AGFSNWTSNFIVGMCFQYIANLCGPY-VFIIFTVFLLTFFIFTYFKVPETKG 444
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
27-447 |
3.66e-58 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 196.70 E-value: 3.66e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 27 AAAVAGLLFGLDIGVIAGAL---PFITDHF----------------TLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGR 87
Cdd:cd17361 1 VAALGGLIFGYDIGISGGVTsmdPFLEKFFpsvyekkkgasennycKYDDQLLQLFTSSLYLAGLVASLLASYVTRKWGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 88 KYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSD 167
Cdd:cd17361 81 KPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 168 TYFSYSG--NWRAMLGVLALPALVLIVLVIFLPNSPrwlaqkgrhveaeevlrmlrdtsekareelneireslklkqggw 245
Cdd:cd17361 161 YGTSKIKpnGWRLSLGLAAVPALILLLGSLFLPETP-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 246 alfkinrnVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFtTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPA 325
Cdd:cd17361 197 --------NSPQLVIAILIPFFQQLTGINVIMFYAPVLFQTLGF-GSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 326 LKIGFSVMAIGTLILGYCLMQFDNGTASSGLSWLSVGMTMMCI--AGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTN 403
Cdd:cd17361 268 LLEGGVQMLASQVAIGILLAVKFGDGGELPKAYAIAVVVLICLyvAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTVAVN 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 658548708 404 WVSNMIIGATFLTLLDAIgAAGTFWLYTVLNVAFIGVTFWLIPE 447
Cdd:cd17361 348 FLFTFVIAQAFLSMLCAM-KFGIFLFFAGWVVVMSLFVYFLLPE 390
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
30-456 |
7.71e-53 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 182.31 E-value: 7.71e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 30 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAA 109
Cdd:cd17436 8 LGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 110 NVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFS-YSGNWRAMLGVLALPAL 188
Cdd:cd17436 88 SFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSnVLTGWRYMFGLAIIPAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 189 VLIVLVIFLPNSPRWLAqkgrhveaeevlrmLRDtsekareelneireslklkqggwalfkinrNVRRAVFLGMLLQAMQ 268
Cdd:cd17436 168 IQFASILLLPKKPEVLN--------------IKD------------------------------NMRRRTLVGLGLVLFQ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 269 QFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclmqfd 348
Cdd:cd17436 204 QFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAVSVSGIGL------ 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 349 ngtassglsWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAGTFW 428
Cdd:cd17436 278 ---------WITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFLDLIDVIGLSWTFL 348
|
410 420
....*....|....*....|....*...
gi 658548708 429 LYTVLNVAFIGVTFWLIPETKGVTLEHI 456
Cdd:cd17436 349 LYGVVGVAGVVFIYLFVPETKGQSLEEI 376
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
24-456 |
7.67e-48 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 170.87 E-value: 7.67e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 24 VSIAAAVAG-LLFGLDIGVIAGALPFITDHF--TLSNR----LQEW--------VVSSMMLGAAIGALFNGWLSFRLGRK 88
Cdd:cd17432 1 ATLAAAFGSsFQYGYNLSVVNSPTPYIQNFYneTWTERygtpLEEStltllwslTVSIFPLGGLFGSLLVGPLVIRLGRK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 89 YSLMVGAILFVAGSIGSAF---AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-- 163
Cdd:cd17432 81 GTLLLNNIFAIVAAILMGLskiAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGqv 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 164 -FLSDTYFSYSGnWRAMLGVLALPALVLIVLVIFLPNSPRW-LAQKGRHVEAEEVLRMLRDtSEKAREELNEIRESLKLK 241
Cdd:cd17432 161 lGLRELLGNEEG-WPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRG-KEDVDDEMEEMLEEQRAE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 242 QGG-----WALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMiATLVVGLTFMFATFIAVFT 316
Cdd:cd17432 239 KGVgtvsvLELFR-DRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQY-VTVGTGACEVLATITCVLV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 317 VDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNgtaSSGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGI 396
Cdd:cd17432 317 IERLGRRPLLIGGFGLMAVWCAVLTVALSLQNT---VSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAF 393
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 397 TCSTTTNWVSNMIIGATFLTLLDAIGAAgTFWLYTVLNVAFIGVTFWLIPETKGVTLEHI 456
Cdd:cd17432 394 MVAGSLNWLSNFLVGLLFPFIQEGLGAY-CFLVFAVICLLTAIYIFFVLPETKGKTFLEI 452
|
|
| MFS_GLUT6_Class3 |
cd17434 |
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
62-454 |
7.86e-46 |
|
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340992 [Multi-domain] Cd Length: 417 Bit Score: 164.62 E-value: 7.86e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMAS 141
Cdd:cd17434 45 WFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 142 ENVRGKMISMYQLMVTLGIVLAFLsdtyFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLR 221
Cdd:cd17434 125 PGVRGALGACPQIMAVFGSLALYA----LGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 222 DTSEKAREELNEIRESLkLKQG---GWALFKiNRNVRRAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIA 298
Cdd:cd17434 201 GPNTDYMTEFEQIKDNI-RKQSsrlSWAELK-TPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEPKYDAA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 299 tlVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQfdngtassglswlsvgMTMMCIAGYAMSAAPV 378
Cdd:cd17434 279 --LVGAVRLLSVAIAASLMDKAGRKILLFTSAFLMFAANLSMGLIPLI----------------AAMLFIMGYAMGWGPI 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658548708 379 VWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPETKGVTLE 454
Cdd:cd17434 341 TWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-382 |
3.20e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.55 E-value: 3.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 16 DTRRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGA 95
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 96 ILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGN 175
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 176 WRAMLGVLALPALVLIVLVIFLpnsprwlaqkgrhveaeevlrMLRDTSEKAREELNEIRESLKlkqggwalfkinrnvR 255
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRL---------------------LPESRPAARARLRGSLRELLR---------------R 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 256 RAVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAI 335
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS-AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 658548708 336 GTLILGYclmqfdngtaSSGLSWLSVGMTMMCIAGYAMSAAPVVWIL 382
Cdd:COG2814 286 GLLLLAL----------AGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-220 |
1.45e-30 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 119.92 E-value: 1.45e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 10 MPAALRDTRRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKY 89
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 90 SLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTY 169
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 658548708 170 FSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRML 220
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAAL 211
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-444 |
5.13e-24 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 102.68 E-value: 5.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFT--LSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSI 103
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 104 GSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSG----NWRAM 179
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 180 LGVLALPALVLIVLviflpnsprwlaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfkinrnvRRAVF 259
Cdd:cd17316 162 FLIGALPALLALLL-------------------------------------------------------------RRRTL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 260 LGMLLQAMQQFtGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLI 339
Cdd:cd17316 181 LLILLWFFISF-GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 340 LGYCLmqfdngtassGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGItcSTTTNWVSNMIIGATFL--TL 417
Cdd:cd17316 260 LFYLL----------SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV--GLSYNLGRLGGGGAPPLiaLL 327
|
410 420
....*....|....*....|....*..
gi 658548708 418 LDAIGAAGTFWLYTVLnVAFIGVTFWL 444
Cdd:cd17316 328 LASTGGTGVPALILAL-LAIVALIVAL 353
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-382 |
1.62e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 101.47 E-value: 1.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 106 AFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLAL 185
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 186 PALVLIVLVIF-LPNSPRwlaqkgrhveaeevlrmlrdtsekareelnEIRESLKLKQGGWALFKiNRNVRRAVFLGMLL 264
Cdd:cd17324 162 LALLAALLLWRlLPSLPP------------------------------KKPGSLGLLSSLLLLLR-NPRLRLAYLITFLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 265 qamqqFTGMNIIM-YYAPRIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGyc 343
Cdd:cd17324 211 -----FGGFFALYtYLAPFLTDVPGFSSS-AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL-- 282
|
330 340 350
....*....|....*....|....*....|....*....
gi 658548708 344 lmqfdngtASSGLSWLSVGMTMMCIAGYAMSAAPVVWIL 382
Cdd:cd17324 283 --------LGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-349 |
2.11e-22 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 98.58 E-value: 2.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 13 ALRDTRRMNQFVSIAAAVAGLLF---GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKY 89
Cdd:TIGR00895 4 NNIRKQPLSRYQWRAIILSFLIMlmdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 90 SLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSDT 168
Cdd:TIGR00895 84 VLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGgFLAGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 169 YFSYSGnWRAMLGV-LALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAREELNEIRESLKLKQGGWAL 247
Cdd:TIGR00895 164 LIPVFG-WRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 248 FKINRNVRRAVFLGMLlqamqqfTGMNIIMYYA-----PRIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDKAGR 322
Cdd:TIGR00895 243 LFQGKTARITVLLWLL-------YFMLLVGVYFltnwlPKLMVELGFSLS-LAATGGALFNFGGVIGSIIFGWLADRLGP 314
|
330 340
....*....|....*....|....*..
gi 658548708 323 KPALkIGFSVMAIGTLILGYCLMQFDN 349
Cdd:TIGR00895 315 RVTA-LLLLLGAVFAVLVGSTLFSPTL 340
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
65-454 |
2.13e-22 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 99.71 E-value: 2.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 65 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENV 144
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 145 RGKMISMYQLMVTLG-IVLAFLSdtYFSYSgnWRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDT 223
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGlVLLPLVA--YFIPD--WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKI 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 224 ------SEKAREELNEIRESLKLKQGGWALFKiNRNVRRAVFLGMLLqamqqFTGMNIIMYYAPRIFKMAGFTTTEQQMI 297
Cdd:TIGR00898 290 ngkklpAEVLSLSLEKDLSSSKKQYSFLDLFR-TPNLRKTTLCLMML-----WFTTAFSYYGLVLDLGNLGGNIYLDLFI 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 298 ATLVVgltfMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYClmqfdngtaSSGLSWLSVGMTMMCIAGyAMSAAP 377
Cdd:TIGR00898 364 SGLVE----LPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFV---------PVDLYFLRTALAVLGKFG-ITSAFQ 429
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 378 VVWILCSEIQPLKCRDFGITCSTTTNWVSNMIigATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLiPETKGVTLE 454
Cdd:TIGR00898 430 MVYLYTAELYPTVVRNLGVGVCSTMARVGSII--SPFLVYLGEKWLFLPLVLFGGLALLAGILTLFL-PETKGVPLP 503
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-443 |
3.55e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 97.88 E-value: 3.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 28 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAF 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 108 AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYF--SYSGNWRAMLGVLAL 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 186 PALVLIVLVIFLPNSPRWLAQKGrhveaeevlrmlrdtsekareelNEIRESLKLKQGGWALFKinrnvRRAVFLGMLLQ 265
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAK-----------------------NEEASSKSVLKLLKRVLK-----NPGLWLLLLAI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 266 AMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclm 345
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 346 qfdngtassGLSWLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGAAG 425
Cdd:cd06174 290 ---------APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360
|
410
....*....|....*...
gi 658548708 426 TFWLYTVLNVAFIGVTFW 443
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-377 |
1.77e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.18 E-value: 1.77e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 29 AVAGLLFGLDIGVIAGALP-FITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAF 107
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 108 AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPA 187
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 188 LVLIVLVIFLPNSPrwlaqkgrhveaeevlrmlrdtsekareelnEIRESLKLKQGGWALFKINRNVRRAVFLGMLLQAM 267
Cdd:pfam07690 162 LLAAVLLLLPRPPP-------------------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 268 QQFTGMNIIMYYAPRIFKMAGFTTteqqMIATLVVGLTFMFATFIAVFT---VDKAGRKPALKIGFSVMAIGTLILGYCL 344
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSA----LLAGLLLGLGGLLGAIGRLLLgrlSDRLGRRRRLLLALLLLILAALGLLLLS 286
|
330 340 350
....*....|....*....|....*....|....*
gi 658548708 345 MQFDNGTASSGLSWLSVGMTMM--CIAGYAMSAAP 377
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVfpALNALVSDLAP 321
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-449 |
6.20e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.78 E-value: 6.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 15 RDTRRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVG 94
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 95 AILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSG 174
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 175 NWRAMLGVLALPALVLIVLviflpnsprwlaqkgrhveaeevlrmlrdtsekareelneireslklkqggwalfkinrnv 254
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 255 rraVFLGMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGR--KPALKIGFSV 332
Cdd:COG2271 181 ---RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 333 MAIGTLILGYclmqfdngtassgLSWLSVGMTMMCIAGYAMSAA-PVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIG 411
Cdd:COG2271 258 AALALLLLAL-------------LPSPALAIALLFLAGFGLGGAfGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324
|
410 420 430
....*....|....*....|....*....|....*...
gi 658548708 412 ATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPETK 449
Cdd:COG2271 325 LLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
36-228 |
3.46e-18 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 87.72 E-value: 3.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 36 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILL 115
Cdd:TIGR01299 180 GVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 116 LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIV----LAFLSDTYFSYS---------GNWRAMLGV 182
Cdd:TIGR01299 260 FCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIyaaaMAWAIIPHYGWSfqmgsayqfHSWRVFVIV 339
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 658548708 183 LALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAR 228
Cdd:TIGR01299 340 CAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRAK 385
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
29-445 |
1.52e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.16 E-value: 1.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 29 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFA 108
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 109 ANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPAL 188
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 189 VLIVLVIFLPnsprwlaqkgrhveaeevlrmlrdtsEKAREELNEIRESLKLKQGGWALFKINRNVrRAVFLGMLLQAMQ 268
Cdd:cd17325 162 LALVLALLLL--------------------------PEPRPPPNKRAVSAARLRSGLRLLLRDRRL-LALFLAIFVLAFA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 269 QFTGMNIIMYYAPRIFKMagftTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYclmqfd 348
Cdd:cd17325 215 FGALEPFLPLYAAELGGL----SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL------ 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 349 ngtaSSGLSWLSVGMTMMCIaGYAMSAAPVVWILCSEIQPlkcRDFGITCST-TTNWVSNMIIGATFLTLL-DAIGAAGT 426
Cdd:cd17325 285 ----ATSFWLLLLLLALLGL-GLGLVFPATLALLADIVPP---EGRGTAMGLfNTAFSLGMVLGPLLGGFLyDAFGFATP 356
|
410
....*....|....*....
gi 658548708 427 FWLYTVLNVAFIGVTFWLI 445
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-451 |
1.68e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.16 E-value: 1.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 106 AFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLAL 185
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 186 PALVLIVLV-IFLPNSPrwlaqkgrhveaeevlrmlRDTSEKAREELNEIRESLKLKQgGWALFkinrnvrrAVFLGMll 264
Cdd:COG2223 168 LLLVVAVLAwLFLRDPP-------------------AGAAAAAKASLRDQLEALRDPR-FWLLS--------LLYFGT-- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 265 qamqqFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGYCL 344
Cdd:COG2223 218 -----FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 345 MQFdngtassglsWLSVGMTMMCIAGYAMSAApVVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLDAIGA- 423
Cdd:COG2223 293 GSL----------WLFLVLFLLLGLALGGGNG-AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSy 361
|
410 420
....*....|....*....|....*...
gi 658548708 424 AGTFWLYTVLNVAFIGVTFWLIPETKGV 451
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
29-220 |
3.65e-17 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 83.09 E-value: 3.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 29 AVAgLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFA 108
Cdd:PRK11551 22 LVA-LLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 109 ANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLAL-PA 187
Cdd:PRK11551 101 WDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgPL 180
|
170 180 190
....*....|....*....|....*....|...
gi 658548708 188 LVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRML 220
Cdd:PRK11551 181 LLVPLLMRWLPESRAFAQAAGAGKQRAPVLRAL 213
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-339 |
3.73e-17 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 83.12 E-value: 3.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 106 AFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDT----YFSYSGNWRAMLG 181
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAllfpLLPPEIAWRVLFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 182 VLALPALVLIVLVIFLPNSPRWLA--QKGRHVEAEEVLRMLRDtsekareelneireslklkqggwalfkinRNVRRAVF 259
Cdd:cd17371 162 LGALPALLVLFIRRFVKEPPQWQAarAARRHFADRPSLRELFS-----------------------------PPLLRTTL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 260 LGMLLQAMQQFTgmniimYYAPRIFkMAGFTTTEQQMIATLVVGLTFMFA------TFIAVFTVDKAGRKPALKIGFSVM 333
Cdd:cd17371 213 LASLLATGALGG------YYGITTW-LPSYLTGERGLSFEGSAGYLVVTIlggflgYLAGGFLADRIGRRNNFALFALGS 285
|
....*.
gi 658548708 334 AIGTLI 339
Cdd:cd17371 286 AISILL 291
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
36-228 |
8.82e-17 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 82.54 E-value: 8.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 36 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILL 115
Cdd:cd17363 12 GVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 116 LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMIS----------MYQLMVTLGIV----LAFLSDTYFSYSgNWRAMLG 181
Cdd:cd17363 92 FCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSwlcmfwmiggLYASAMAWAIIphygWGFSMGTAYQFH-SWRVFVI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 658548708 182 VLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAR 228
Cdd:cd17363 171 VCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMRAK 217
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
26-448 |
2.30e-16 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 80.78 E-value: 2.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFI-----TDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVA 100
Cdd:cd17364 2 IIAGMGFFTDAYDLFSISLVTKILgrlyyGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 101 GSIGSAFAANVE------ILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA----------- 163
Cdd:cd17364 82 GTILSALSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGaivtlilsaif 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 164 ---FLSDTYFSYSGNWRAMLGVLALPALVLIVLviflpnsprwlaqkgrhveaeevlrmlrdtsekareelneiRESLKL 240
Cdd:cd17364 162 ehpLPAGTYHHADLVWRIVLGLGAIPALSVLYF-----------------------------------------RKHLLG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 241 KQGGWALFKInrnvrravflgmllqamqQFTGMNIimyYAPRIFKMAGFTTT-----EQQMIATLVVGLTFMFAT---FI 312
Cdd:cd17364 201 TAGTWFLLDI------------------AFYGQNL---FQSTIISAIGFSKTmnayqELFNIAVGQLIIALAGTVpgyWF 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 313 AVFTVDKAGRKPALKIGFSVMAIGTLILGYCLMQFDNGTAssglswLSVGMTMMCIAGYAMSAAPVVWILCSEIQPLKCR 392
Cdd:cd17364 260 TVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTI------GFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVR 333
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 658548708 393 DFGITCSTTTNWVSNMIIGATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPET 448
Cdd:cd17364 334 STCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
45-340 |
6.10e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 79.16 E-value: 6.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 45 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVA 124
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 125 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLpnsprwl 204
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 205 aqkgrhveaeevlrmlrdtsekareeLNEIRESLKLKQGGWALFKINRNV-RRAVFLGMLLQAMQQFTGMNIIMYYAPRI 283
Cdd:cd17320 174 --------------------------LPETLPEEKRKPLLSSLLRAYKRVlKNRRFLGYALALGLSFAGLFAYLAAAPFI 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 284 FKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIL 340
Cdd:cd17320 228 YIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVL 284
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-344 |
1.77e-15 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 78.05 E-value: 1.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 30 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAA 109
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 110 NVEILLLSRVLlgVAVGIASYT--APLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYF-SYSGNWRAMLGVLALP 186
Cdd:cd17328 86 NFWQLLLFRAL--VGIGEASYSpiAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 187 ALVLIVLVIFLPNSPRwlaqkgRHVEAEEVLRMLRDTSekareelneireslkLKQGGWALFKInrnvrRAVFLGMLlqa 266
Cdd:cd17328 164 GVLLAILLLLFVREPP------RGAAEGGVMAKSTATS---------------FLADLKALAKN-----PSFILSTL--- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 267 mqQFTGMNI--------IMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPAlKIGFSVMAIGTL 338
Cdd:cd17328 215 --GFTAVSFvtgalafwAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTP-RADPLVCAVGLL 291
|
....*.
gi 658548708 339 ILGYCL 344
Cdd:cd17328 292 AAAPFL 297
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
59-444 |
2.36e-15 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 76.85 E-value: 2.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 59 LQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSE 138
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 139 MASENVRGKMISMYQLMVTLGIV-LAFLSdtyfSYSGNWRAMLGVLALPALVLIVLVIFLPnsprwlaqkgrhveaeevl 217
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMlLALLA----YLIRDWRWLQLAISLPGLLFLLLLWWLP------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 218 rmlrdtsekareelneireslklkqggwalfkinrnvRRAVFLGMLLqamqqftGMNIIMYYA--PRIFKMAGfttteQQ 295
Cdd:cd17317 163 -------------------------------------RRTIIVGLIW-------FVTSLVYYGlsLNSSNLGG-----NL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 296 MIATLVVGLTFMFATFIAVFTVDKAGRKPALkigFSVMAIGTLILGYCLMQFDNgtassglsWLSVGMTMMCIAGYAMSA 375
Cdd:cd17317 194 YLNFFLSGLVEIPAYFLALLLLDRLGRRWTL---SGSLLLAGLACLVTALLPDD--------ENTLALTLALVGKFAISA 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658548708 376 A-PVVWILCSEIQPLKCRDFGI-TCSTttnwVSNM-IIGATFLTLLDAIGAAGTFWLYTVLNVAFIGVTFWL 444
Cdd:cd17317 263 AfSVIYLYTAELYPTVVRNTGVgLCST----VARVgAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-194 |
3.52e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 76.83 E-value: 3.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 29 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFA 108
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 109 ANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPAL 188
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
....*.
gi 658548708 189 VLIVLV 194
Cdd:cd17321 162 VALLLA 167
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
36-242 |
3.90e-15 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 77.26 E-value: 3.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 36 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILL 115
Cdd:cd17440 12 GVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 116 LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLG------IVLAFLSDTYFSYS-------GNWRAMLGV 182
Cdd:cd17440 92 FCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGgiyasaMAWAIIPHYGWSFSmgsayqfHSWRVFVIV 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 183 LALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAREELNEIRESLKLKQ 242
Cdd:cd17440 172 CALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQPEKVFTVNRIKK 231
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-340 |
1.11e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.66 E-value: 1.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 17 TRRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAI 96
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 97 LFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTYFSYSG-- 174
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 175 -NWRAMLGVLALPALVLIVLVIFLPnsprwlaqkgrhveaeevLRMLRDTSEKAREELNEIRESLKLKQGGWALFkinrn 253
Cdd:COG0738 161 lSWHLPYLILAVLLLLLALLFLRSK------------------LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGL----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 254 vrrAVFLGMLLQAMqqftgmniIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVM 333
Cdd:COG0738 218 ---AIFLYVGAEGA--------IGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286
|
....*..
gi 658548708 334 AIGTLIL 340
Cdd:COG0738 287 AVGLLLA 293
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
36-230 |
1.11e-14 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 76.11 E-value: 1.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 36 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILL 115
Cdd:cd17438 12 GVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 116 LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA--------------FLSDTYFSYSgNWRAMLG 181
Cdd:cd17438 92 FCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYAsamawsiiphygwgFSMGTNYHFH-SWRVFVI 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 658548708 182 VLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAREE 230
Cdd:cd17438 171 ICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMRAKGT 219
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-194 |
1.26e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 74.93 E-value: 1.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 33 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVE 112
Cdd:cd17365 9 VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 113 ILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIV 192
Cdd:cd17365 89 QLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
..
gi 658548708 193 LV 194
Cdd:cd17365 169 LL 170
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-202 |
1.41e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.29 E-value: 1.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 7 STLMPAALRDTRRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLG 86
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 87 RKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVrGKMISMYQLMVTLGIVLAFLS 166
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGL 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 658548708 167 DTYFSYSGNWRAMLGVLALPALV-LIVLVIFLPNSPR 202
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLaLLLWLPLLRRRPA 197
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-341 |
1.08e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 1.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 39 IGVIAGALPFITDHFTLSNRLQ-EWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLS 117
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 118 RVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSySGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:cd17473 95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 198 PNSPRwlaqkgrhveaeevlrmlrdTSEKAREELNEIRESLKLKQGGWALFkinrnvrrAVFLGMLLqamqqftgMNIIM 277
Cdd:cd17473 174 PEPAR--------------------KSKSAASPGAATAAALPWKRVLPIYF--------LAFLAMLL--------FYVIP 217
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658548708 278 YYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILG 341
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA 281
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
26-449 |
3.09e-13 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 71.17 E-value: 3.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHF-----TLSNRLQEWVVSSM-MLGAAIGALFNGWLSFRLGRKYSLMVGAILFV 99
Cdd:cd17367 2 LGGSVGNLVEWYDWYVYAAFALYFAPQFfpsgdPTVALLSTAAVFAVgFLMRPIGGWLFGRLADRIGRRAALTLSVSLMA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 100 AGSIGSAFAANVE--------ILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFS 171
Cdd:cd17367 82 AGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 172 Y--------SGNWRAMLGVLALPALVLIVLVIFLPNSprwlaqkgrhveaeevlrmlrdtsekarEELNEIRESLKLKQG 243
Cdd:cd17367 162 HtlgedqmaAWGWRIPFLLGGVLAVVVLWLRRGLEET----------------------------ESFEAIAESNEASAG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 244 GWALFkinRNVRRAVFLGMLLQAmqqftGMNIIMY----YAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDK 319
Cdd:cd17367 214 TLREL---RRHPRELLLVVGLTA-----GGTLAFYtwttYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDR 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 320 AGRKPALkIGFSVMaiGTLILGYCLMQFDNGTASSGLswLSVGMTMMCIAGYAMSAAPVVWilcSEIQPLKCRDFGITCS 399
Cdd:cd17367 286 IGRRPLL-LFFGIG--GTLATVPLLSALDHTDSPYTA--FALVLVGLVFLSGYTSINAVVK---AELFPTHVRALGVGLP 357
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 658548708 400 TTtnwVSNMIIGAT---FLTLLDAIGAAGTFWLYTVLNVAFIGVTFWLIPETK 449
Cdd:cd17367 358 YA---LAVAIFGGTapyVALWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-342 |
4.94e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 4.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 30 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAA 109
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 110 NVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-FLSDTYFSYSGNWRAMLGVLALPAL 188
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGpALGLFLYQHLGFAVLFIVAAVLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 189 VLIVlviflpnsprwlaqkgrhveaeeVLRMLRDTSEKAREELNEIRESLKLkqggwalfkinrnVRRAVFLGMLLQAMQ 268
Cdd:cd17489 163 ALLL-----------------------VFLVKDPPPVAAEEAEAGTRAFRRL-------------VEKKVLPPALILFLA 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658548708 269 QFTGMNII----MYYAPRIFKMAGFTTTeqqmiatlVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGY 342
Cdd:cd17489 207 SIAYGAIStflpLYAAERGISNAGLFFT--------VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF 276
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-342 |
1.62e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 1.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 106 AFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL-----AFLSDTYfsysgnWRAML 180
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVgpllgGLLAAIS------WRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 181 GVLALPALVLIVLVIFLPNSPrwlaqkgrhveaeevlrmlrdtSEKAREelneireslKLKQGGWALFKInrnVRRAVFL 260
Cdd:cd17474 156 FLLAALIPVAFLAILFLLPEP----------------------KEKAKS---------SSATKLRDLKKA---LRGRGLL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 261 GMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFM-FATFIAVFTVDKAGRKPALKIGFSVMAIGTLI 339
Cdd:cd17474 202 TFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLAlGSLFVGRLLKKRFGARRILVIGLLLYALSLLL 281
|
...
gi 658548708 340 LGY 342
Cdd:cd17474 282 LGF 284
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
41-199 |
5.40e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 67.22 E-value: 5.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 41 VIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVL 120
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 121 LGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLA-LPALVLIVLVIFLPN 199
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAiISGFCLILIFLFLPI 176
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-342 |
7.20e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.83 E-value: 7.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 29 AVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFA 108
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 109 ANVEILLLSRVLLGVAVGIasytAPLYLSeMASENVRGKMISMYQLMVT----LGIVLAFLSDTYFSYSGNWRAMLGVLA 184
Cdd:cd17504 82 PNLPVLIAGRALQGIGGAV----FPLAFA-LVREEFPPERVPVAQGILSatfgIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 185 LPALVLIVLVIFLPnsprwlaqkgrhveaeevLRMLRdtsekareelneireslklkqggwalfkinrnvRRAVFLGMLL 264
Cdd:cd17504 157 PVAVLLAALVPLID------------------LRLLR---------------------------------RRNVLLANIT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 265 QAMQQFtGMNIIMYYAPRIFKMAGFTTTEQQMIATLVV----GLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIL 340
Cdd:cd17504 186 ALLAGF-GMFMVFQLLPQLLQLPTPTGFGLGITEAGLLllpgALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLL 264
|
..
gi 658548708 341 GY 342
Cdd:cd17504 265 AL 266
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
70-458 |
9.13e-12 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 67.06 E-value: 9.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 70 GAAIGALFNGWLSFRLGRKYS------LMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASEN 143
Cdd:TIGR00887 68 GTLAGQLFFGWLADKLGRKRVygmeliIMIIATVASGLSPGSSPKSVMATLCFWRFWLGVGIGGDYPLSAIITSEFATKK 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 144 VRGKMISMY-------QL---MVTLGIVLAFLSD-----TYFSYSGN--------WRAMLGVLALPALVLIVLVIFLPNS 200
Cdd:TIGR00887 148 WRGAMMAAVfamqgfgILagaIVALIVLAGFKHSleaaaDEASCTGScvpavdymWRILIGFGAVPALLALYFRLTIPET 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 201 PRWLAQKGRHVE--AEEVLRMLRDTSEKAREELNEIRESLKLKQGGWALFkINRNVRRAVFLGMLLQAMQQFTgMNIIMY 278
Cdd:TIGR00887 228 PRYTADVAKDVEqaASDMSAVLQVKIEAEPDEVEKASTAVEVPKASWSDF-FTHFFKWRHGKHLLGTAGSWFL-LDIAFY 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 279 ----YAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIA-----------VFTVDKAGRKPALKIGFSVMAIGTLILGYC 343
Cdd:TIGR00887 306 gvnlNQKVILSAIGYSPPAATNNAYEELYKTAVGNLIIAlagtvpgywvtVFLVDIIGRKPIQLMGFFILTVLFFVLGFA 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 344 LmqfdNGTASSGLswlsvgMTMMCIAGYAMSAAP--VVWILCSEIQPLKCRDFGITCSTTTNWVSNMIIGATFLTLLD-- 419
Cdd:TIGR00887 386 Y----NHLSTHGF------LAIYVLAQFFANFGPnaTTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQhg 455
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 658548708 420 --------AIGAAGTFWLYTVLNVAFIGVTFwLIPETKGVTLEHIER 458
Cdd:TIGR00887 456 dptkgyptGIWMGHVLEIFALFMFLGILFTL-LIPETKGKSLEELSG 501
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-197 |
9.98e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 9.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALP-FITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIG 104
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 105 SAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLA 184
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
170
....*....|...
gi 658548708 185 LPALVLIVLVIFL 197
Cdd:cd17325 362 ALLLLAAVLFLLL 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-377 |
1.63e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 65.68 E-value: 1.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 28 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAF 107
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 108 AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA-----FLSDTYfsysgNWRAMLGV 182
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGptlggWLTDNL-----SWRWIFYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 183 LALPALVLIVLVIFLPnsprwlaqkgrhveaeevLRMLRDtsekareelneireslklkqggwalfkinRNVRRAVFLGM 262
Cdd:cd17503 156 NLPIGILALLLAPLLD------------------LRLFKD-----------------------------RNFTLGLLLSF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 263 LLQAmqqftGMNIIMYYAPRIFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIlgy 342
Cdd:cd17503 189 LLGL-----GLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLL--- 260
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 658548708 343 cLMQFDNGTASSGLSW------LSVGMTMMCIAGYAMSAAP 377
Cdd:cd17503 261 -LAFLTPDTSLWLIILplfirgLGMGLVFMPLNTLALNSLP 300
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
36-228 |
5.22e-11 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 64.67 E-value: 5.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 36 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILL 115
Cdd:cd17439 12 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 116 LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIV----LAFLSDTYFSYS---------GNWRAMLGV 182
Cdd:cd17439 92 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIyasaMAWAIIPHYGWSfqmgsayqfHSWRVFVLV 171
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 658548708 183 LALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLRDTSEKAR 228
Cdd:cd17439 172 CAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMRAK 217
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
30-177 |
1.80e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 62.20 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 30 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQeWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAA 109
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 658548708 110 NVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWR 177
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWR 149
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
37-197 |
4.42e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 4.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 37 LDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLL 116
Cdd:cd17319 17 LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 117 SRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIF 196
Cdd:cd17319 97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF 176
|
.
gi 658548708 197 L 197
Cdd:cd17319 177 Y 177
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-202 |
4.92e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.04 E-value: 4.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 30 VAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAA 109
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 110 NVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGnWRAMLGVLALPALV 189
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG-ALPFLIAAVLLLLA 161
|
170
....*....|...
gi 658548708 190 LIVLVIFLPNSPR 202
Cdd:cd17477 162 LVPLLLTRRAAPE 174
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-367 |
1.32e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 60.09 E-value: 1.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 23 FVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGS 102
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 103 IGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGV 182
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 183 LALPAL-VLIVLVIFLPNSPRWLAQK----GRHVEAEEVLRMLRDTSEKAREELNEIRESLKLKQGG---------WALF 248
Cdd:TIGR00711 162 NVPIGIiVVVVAFFILPRDKPAASENfdflGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGlvaiiafvvWELT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 249 KINRNVRRAVF---------LGMLLQAMQQFTGMNIIMYYaprIFKMAGFTTTeQQMIATLVVGLTFMFATFIAVFTVDK 319
Cdd:TIGR00711 242 DDNPLVDLRLFkyrnftigcVYMSLLGLGLYGSFYLLPLY---LQQVLGYTAL-QAGLHILPVGLAPMLSSPIAGRMGDK 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 658548708 320 AGRKPALKIGFSVMAIGTLILGYCLmQFDNGTASSGLSWLSVGMTMMC 367
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFTF-TPDTPFLAIALPQFIRGFGMGC 364
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-197 |
2.13e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.17 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 19 RMNQFVSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILF 98
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 99 VAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRA 178
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 658548708 179 MLGVLALPALVLIVLVIFL 197
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-163 |
4.09e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 4.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 24 VSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSI 103
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 104 GSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 163
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
45-197 |
4.49e-09 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 58.16 E-value: 4.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 45 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVA 124
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658548708 125 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-201 |
7.91e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 57.33 E-value: 7.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 33 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVE 112
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 113 ILLLSRVLLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIV 192
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLA 164
|
....*....
gi 658548708 193 LVIFLPNSP 201
Cdd:cd17333 165 ILILLTLFP 173
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
62-193 |
1.18e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMAS 141
Cdd:cd17473 237 LALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVP 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 142 ENVRGKMISMYQLMVTLG-----IVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVL 193
Cdd:cd17473 317 PELRGRAMGIVTSAFFLGqflspLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
25-198 |
3.27e-08 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 55.23 E-value: 3.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 25 SIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIG 104
Cdd:cd17372 1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 105 SAFAANVEILLLSRVLLGVAVGIASYTAPLYLsEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLA 184
Cdd:cd17372 81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSS 159
|
170
....*....|....
gi 658548708 185 LPALVLIVLVIFLP 198
Cdd:cd17372 160 VPSSLLLVFYRWTP 173
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
65-202 |
6.33e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 54.51 E-value: 6.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 65 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENV 144
Cdd:PRK11043 48 SLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQK 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 658548708 145 RGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPR 202
Cdd:PRK11043 128 ANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKK 185
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-197 |
8.29e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.11 E-value: 8.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 18 RRMNQFVSIAAAVAGLLFGLDIGVIAGALPFITD-HFTLSNRLQEWVVSSMMLGAAIGALFNG-WLSFRLGRKYSLMVGA 95
Cdd:cd17474 193 KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 96 ILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGN 175
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
170 180
....*....|....*....|..
gi 658548708 176 WRAMLGVLALPALVLIVLVIFL 197
Cdd:cd17474 353 LSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-197 |
1.16e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.75 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 12 AALRDTRRMNQFVSIAAAVAGLLFGLDIgVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSL 91
Cdd:COG2211 219 ESLKALLKNRPFLLLLLAYLLFFLALAL-VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 92 MVGAILFVAGSIGSAFA--ANVEILLLSRVLLGVAVGIASYTAPLYLSEMA-------SENVRGKMISMYQLMVTLGIVL 162
Cdd:COG2211 298 IIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQAL 377
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 658548708 163 A------------FLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:COG2211 378 AgalaglllalfgYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLL 424
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
45-197 |
1.41e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 53.38 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 45 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVA 124
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658548708 125 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFF 165
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
62-202 |
1.71e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.40 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLyLSEMAS 141
Cdd:cd06179 36 WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVP 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 658548708 142 ENVRGKMISMYQLMVTLGIVLAFLSDTYF--SYSGNWR---AMLGVLALPALVLIVLVIFLPNSPR 202
Cdd:cd06179 115 NKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRwifYINAIFNALALILLFFFYHPPPRPQ 180
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
15-217 |
2.12e-07 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 53.52 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 15 RDTRRMNQFVSIAAAVAGLLFGLDIGviAGALPFITDHFTLSNRlQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVG 94
Cdd:pfam06609 38 RSPRIIASFAAFSLNVCATYFVLQAS--ASALPNILQDIGQSEN-QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAT 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 95 AILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASyTAPLYLSEMASEnvRGKMISMyqLMVTLGIVLAFLSDTYF---- 170
Cdd:pfam06609 115 HIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAG-ASPLFIGELMSN--KTKFLGL--LIVSAPTIAMNGAGPYFgqrl 189
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 658548708 171 SYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVL 217
Cdd:pfam06609 190 AIQGNWRWIFYIYIIMSAIAVLLIIIWYHPPSFAQLHGKKARKRDEL 236
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
58-204 |
3.06e-07 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 52.51 E-value: 3.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 58 RLQEW----VVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAP 133
Cdd:cd17441 30 RLPSWqvalLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVT 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658548708 134 LYlSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWL 204
Cdd:cd17441 110 LY-AEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYW 179
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
26-208 |
3.08e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 52.78 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:PRK03893 23 SAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLAC 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 106 AFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGK----MISMYqlmvTLGIVLAFLSDTYFSYSGNWRAMLG 181
Cdd:PRK03893 103 GFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKasgfLISGF----SIGAVVAAQVYSLVVPVWGWRALFF 178
|
170 180
....*....|....*....|....*..
gi 658548708 182 VLALPALVLIVLVIFLPNSPRWLAQKG 208
Cdd:PRK03893 179 IGILPIIFALWLRKNLPEAEDWKEKHA 205
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
65-341 |
4.14e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.83 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 65 SSMMLGAAIG------ALFN---GWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLG----VAVGIAsyt 131
Cdd:cd17472 30 TPTLIGLALGiygltqAIFQipfGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGsgaiSSVVMA--- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 132 aplYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAM-LGVLALPALVLIVLVIFLPNSPRwlAQKGRH 210
Cdd:cd17472 107 ---LLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLfLITAILSLVSLLILLFFVPDPPK--IVQISE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 211 VEAEEVLRMLRDtsekareelneireslklkqggWALFKINrnvrravFLGMLLQAMqqftgMNIIMYYAPRIFKMAGFT 290
Cdd:cd17472 182 KEKKKLKKLLKN----------------------KRLLRLD-------FSIFILHFV-----LMAFFYILPLLLTQLGGG 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 658548708 291 TTEQQMIATLVVGLTFmFATFIAVFTVDKAGR-KPALKIGFSVMAIGTLILG 341
Cdd:cd17472 228 KGQLWKVYLPAILIGF-ILMVPFVIYAEKKGKmKQVFVSSILLIAVGFLLLL 278
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
27-222 |
1.31e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 50.31 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 27 AAAVAGLLFGLDIGVIAgalPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSA 106
Cdd:cd17475 3 LAQAAASLVAQGIPALA---PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 107 FAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALP 186
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 658548708 187 ALVLIVLVI-FLPNSPRWLAQKGR-HVEAEEVLRMLRD 222
Cdd:cd17475 160 SILAAVLFWlFYREPPAASAATESaSTLLRSLKEVLRN 197
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
45-202 |
1.41e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.45 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 45 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVA 124
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 125 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTL-GIVLAFLSDTYFSYSGNWRAMLGVLALPALVL-IVLVIFLPNSPR 202
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVsLICFLLLRDSPQ 176
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-163 |
1.65e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658548708 106 AFAANVE---ILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 163
Cdd:pfam07690 283 LLLSLTLsslWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
70-198 |
3.35e-06 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 49.01 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 70 GAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMI 149
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAG 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 658548708 150 SMYQLMVTLGIVLAFLSDTYFSysgNWRAMLGVLALPALVLIVLVIFLP 198
Cdd:cd17377 131 SLGGLFFAVGIAQYALLGYFIR---SWRTLAVVVNLQGTLVFLLSLFIP 176
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
73-429 |
4.95e-06 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 48.52 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 73 IGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVE--------ILLLSRVLLGVAVGIASYTAPLYLSEMASENV 144
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 145 RGKMISM----YQLMVTLGIVLAFLSDTYFSY----SGNWRA--MLGVLALPalVLIVLVIFLPNSPRWLAQKgRHVEAE 214
Cdd:cd17368 135 RGFYTSWqsasQQVAIVAGALVGYLLSLTLTAealaEWGWRIpfFIGLLIIP--LGLWLRRSLEETEAFLERK-ARPTRR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 215 EVLRMLRdtsekareelneireslklkqggwalfkinrNVRRAVFLGMLLQAMQQFTgMNIIMYYAPRIFKMAGFTTTEQ 294
Cdd:cd17368 212 ELFALLA-------------------------------NNRRIILLGMLLVAGSTVT-FYFTTVYTPTYAKTVLGLSARD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 295 QMIATLVVGLTFMFATFIAVFTVDKAGRKPALkigfSVMAIGTLILGYCLMQFdnGTASSGLSWLSVGMTMMCIAGyAMS 374
Cdd:cd17368 260 SFLVTLLAGVANFIWAPLGGALSDRIGRRPVL----LVITLAALVTLYPVFAW--LTAAPSFGRLLLVLLVLSFFF-GMY 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658548708 375 AAPVVwILCSEIQPLKCRDfgiTCSTTTNWVSNMIIG------ATFLTLLDAIGAAGTFWL 429
Cdd:cd17368 333 GGAMV-VALVELFPVRVRS---TGFSLVYALAVAIFGgfaqfiVTWLIELTGSPLAPAWYL 389
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
56-198 |
7.98e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 47.67 E-value: 7.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 56 SNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAV-GIASYTAPL 134
Cdd:cd17374 33 SQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTLIL 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658548708 135 yLSEMASENVRGKMISMYQLMVTLGIVLafLSDTYFSYSgNWRAMLGVLALPALVLIVLVIFLP 198
Cdd:cd17374 113 -GTEWTTPRHRALAITLTSCFFSIGQML--LAGLAYAIR-DWRLLQLVVSVPFFLFFLYSWWLP 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
45-340 |
1.04e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 45 ALPFITDHFTLSNrlqeWVVSSMMLGAAIGALFN----GWLS----FRLGRKYS-LMVGAILFVAGSIGSAFA------A 109
Cdd:COG2211 33 LLYFYTDVLGLSA----ALVGLILLVARLWDAITdpliGALSdrtrTRWGRRRPwILIGAIPLALSFVLLFTApdlsptG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 110 NVEILLLSRVLLGVAVGIAS--YTAplYLSEMASE-NVRGKMISMYQLMVTLGIVLA------FLSDTYFSYSGNWRAML 180
Cdd:COG2211 109 KLIYALVTYLLLGLAYTLVNipYSA--LGAELTPDyEERTRLSSWRFAFAGLGGLLAsvlpppLVAAFGGDAALGYRLTA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 181 GVLALPALVLIVLVIFLpnsprwlaqkgrhveaeevlrmlrdtsekAREELNEIRESLKLKQGGWALFKiNRNVRRaVFL 260
Cdd:COG2211 187 LIFAVLGLLAFLLTFFG-----------------------------TKERPVPEEEKVSLKESLKALLK-NRPFLL-LLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 261 GMLLQAMQQFTGMNIIMYYAPRIFKMAGFTTTeqqmIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLIL 340
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVG----LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-222 |
1.08e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.61 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 46 LPFITDHFTLSNRLQEWVVSSMM----LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLL 121
Cdd:cd17329 19 WPFMAIYLHQQLGLSASIVGLVLalsaVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 122 GVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVL-AFLSDTYFSYSGNWRAMLGVLALpALVLIVLVIFLPNS 200
Cdd:cd17329 99 GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIgPLLGGLLLLYSFRLLFLAAAVLF-LLAALVLLFLLPET 177
|
170 180
....*....|....*....|..
gi 658548708 201 PRWLAQKGRHVEAEEVLRMLRD 222
Cdd:cd17329 178 RPKRRAAEKTEILRGYKIVLRD 199
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-202 |
1.20e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 40 GVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRV 119
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 120 LLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPN 199
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
...
gi 658548708 200 SPR 202
Cdd:cd17478 172 LKK 174
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
73-375 |
2.68e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 46.37 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 73 IGALFNGWLSFRLGRKYSLMV-----GAILFVAG------SIGSAFAAnveILLLSRVLLGVAVGIASYTAPLYLSEMAS 141
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLtlllmGIATFLIGllptyaQIGILAPI---LLVLLRLLQGLALGGEWGGAVLMAVEHAP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 142 ENVRGKMISMYQLMVTLGIVLA---------FLSDTYFSYSGnWRamLGVLALPALVLIVLVIFLpnsprwlaqkgrHVE 212
Cdd:cd17369 136 PKRRGFYGSFPQLGAPVGLLLAtgvflllsaLLSDEAFLSWG-WR--IPFLLSAVLVAVGLYIRL------------RLE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 213 AEEVLRMLRDTSEKAREELNEIReslklkqggwalfkinRNVRRAVFLGMLLQAMQQ---FTGMNIIMYYAPRIFKMAGF 289
Cdd:cd17369 201 ETPVFRRAKEAGQVVRAPLVEVL----------------RRHWRALLLAIGLRLAENvlfYLFTTFALSYATQTLGVDRS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 290 TTTEQQMIATLVVGLTFMFATFIAvftvDKAGRKPALKIGfsvmAIGTLILGYCLMQFdngtASSGLSWLSVgMTMMCIA 369
Cdd:cd17369 265 TVLLAVLIASVVAAITIPLFGWLS----DRVGRRPVYLAG----ALLAALFAFPFFWL----LDTGSTWLIV-LAAVVVL 331
|
....*.
gi 658548708 370 GYAMSA 375
Cdd:cd17369 332 GVLHGM 337
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
73-337 |
4.01e-05 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 45.70 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 73 IGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAF---------AANVeILLLSRVLLGVAVGIASYTAPLYLSEMASEN 143
Cdd:PRK15075 71 LGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIAFvpgyatiglAAPL-LVLLGRLLQGFSAGVELGGVSVYLAEIATPG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 144 VRGKMISM----YQLMVTLGIVLAFLSDTYFSY----SGNWRamlgvlaLPALV--LIVLVIFLpnsprwlaqkgrhvea 213
Cdd:PRK15075 150 RKGFYTSWqsasQQVAVVFAALLGYLLNQWLSPaqmaEWGWR-------IPFLIgcLIVPFIFL---------------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 214 eeVLRMLRDTSE----KAREELNEIRESLKlkqGGWalfkinrnvrRAVFLGMLLQAMQQfTGMNIIMYYAPRIFKMAGF 289
Cdd:PRK15075 207 --IRRSLEETEEflarKHRPSMREIFRSLA---ANW----------RIVLAGMLMVAMTT-VSFYLITVYTPTFGKTVLH 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 658548708 290 TTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALkIGFSVMAIGT 337
Cdd:PRK15075 271 LSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVL-IAFTVLAILT 317
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
67-189 |
4.40e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.61 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 67 MMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRG 146
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 658548708 147 KMISMYQLMVTLGIVLA-----FLSDTY-----FSYSgnwrAMLGVLALPALV 189
Cdd:cd17370 323 TAYGLFNTVVGIGWLLAsliagYLWDLIspsaaFLFS----AVLALIALLLLL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
45-204 |
4.64e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.34 E-value: 4.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 45 ALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVA 124
Cdd:cd17312 25 AKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 125 VGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWR-AMLGVLALPALVLIVLVIFLPNSPRW 203
Cdd:cd17312 105 QSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRaAFLVPGIVGLVVAIILFFFLRDSPPY 184
|
.
gi 658548708 204 L 204
Cdd:cd17312 185 V 185
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
65-197 |
9.22e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 44.63 E-value: 9.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 65 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENV 144
Cdd:PRK10473 45 SVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 145 RGKMISMYQ----LMVTLGIVLAFLSDTYFSysgnWRAMLGVLALPALVLIVLVIFL 197
Cdd:PRK10473 125 RAKVLSLLNgitcIIPVLAPVLGHLIMLKFP----WQSLFYTMAAMGILVLLLSLFI 177
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
36-207 |
1.15e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 44.53 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 36 GLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILL 115
Cdd:PRK12307 31 GFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 116 LSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVI 195
Cdd:PRK12307 111 LSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRA 190
|
170
....*....|..
gi 658548708 196 FLPNSPRWLAQK 207
Cdd:PRK12307 191 RAPESKEWEEAK 202
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-204 |
1.29e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.11 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASyTAPLYLSEMAS 141
Cdd:cd17330 38 LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS-VAQAYIADITD 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658548708 142 ENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWL 204
Cdd:cd17330 117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRL 179
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
33-221 |
1.55e-04 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 43.88 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 33 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVE 112
Cdd:PRK03633 16 LLLTLAIAVLNTLVPLWLAQEHLPTWQVGVVSSSYFTGNLVGTLLAGYVIKRIGFNRSYYLASLIFAAGCAGLGLMVGFW 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 113 ILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLAFLSDTYFSysgnwRAMLGVlaLPALVLIV 192
Cdd:PRK03633 96 SWLAWRFVAGIGCAMIWVVVESALMCSGTSRNRGRLLAAYMMVYYLGTVLGQLLVSKVS-----TELMSV--LPWVTGLV 168
|
170 180 190
....*....|....*....|....*....|
gi 658548708 193 LVIFLPNS-PRWLAQKGRHVEAEEVLRMLR 221
Cdd:PRK03633 169 LAAILPLLfTRILNQQAENHDSTSIWPMLK 198
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
68-340 |
1.58e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.75 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 68 MLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSR-VLLGVAVGIAsYTAPLYLSEMASENVRG 146
Cdd:cd17353 48 IVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGIG-YITPVSTAVKWFPDKRG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 147 kMISMyqlMVTLG-----IVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPRWLAQKGRHVEAEEVLRMLR 221
Cdd:cd17353 127 -LATG---IVIAGfglgsLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 222 DTSekareelneIRESLKLKQgGWALFkinrnvrravflgmLLQAMQQFTGMNIIMYYAPRIFKMAGFTTteqqMIATLV 301
Cdd:cd17353 203 DYT---------PREMLRTPT-FWLLW--------------LMFFLNATAGLMLIGQAKPIGQEFAGLDA----GIAALA 254
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 658548708 302 VGLTFMFATF---IAVFTVDKAGRKPALKIGFSVMAIGTLIL 340
Cdd:cd17353 255 VSILSIFNGGgrpFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-197 |
1.69e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 69 LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKM 148
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 658548708 149 ISMYQLMVTLGIVL-AFLSDTYFSYSGnWRAMLGVLALPALVLIVLVIFL 197
Cdd:cd17489 318 NGTFFIFFDLGIGLgGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
84-197 |
1.71e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 84 RLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLGIVLA 163
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341
|
90 100 110
....*....|....*....|....*....|....
gi 658548708 164 FLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:cd17329 342 PLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
65-198 |
2.16e-04 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 43.11 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 65 SSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENV 144
Cdd:cd17379 40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 658548708 145 RGKMISMYQLMVTLGIVLaFLSDTYFSYsgNWRAMLGVLALPALVLIVLVIFLP 198
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLI-LPGIAYFIP--HWRWLQLAVTLPNFLFLLYYWFIP 170
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
24-195 |
2.39e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 24 VSIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSI 103
Cdd:cd17324 200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 104 GSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENvRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVL 183
Cdd:cd17324 280 LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
|
170
....*....|..
gi 658548708 184 ALPALVLIVLVI 195
Cdd:cd17324 359 AALLLLALLLAL 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
54-376 |
3.21e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.98 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 54 TLSNRLQEWVVSSMMLGAAIGA---------LFNGWLSFRLG-RKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGV 123
Cdd:cd17490 18 FLSPYAESLGASLSMIGIILGAygisqmllrIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 124 AVGI-ASYTApLYLSEMASENVrGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNSPR 202
Cdd:cd17490 98 AAATwVSFTV-LYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 203 wlaqkgrhveaeevlrmlrdTSEKAREELNEIRESLKlkqggwalfkiNRNVRRAVFLGMLlqamQQFTGMNIIMYYAPR 282
Cdd:cd17490 176 --------------------EKKPVLTELKELLSVLK-----------DKKLLFFSLLAIL----QQMITFSTTFGFTPL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 283 IFKMAGFTTTEQQMIATLVVGLTFMFATFIAVFTVDKAGRKPALKIGFSVMAIGTLILGY-------CLMQFDNGTASSG 355
Cdd:cd17490 221 IAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFapnltllYLLQALNGFGTGI 300
|
330 340
....*....|....*....|.
gi 658548708 356 LSWLSVGMTMMCIAGYAMSAA 376
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRSTA 321
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
65-198 |
4.04e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 42.35 E-value: 4.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 65 SSMMLGAAIGALFNGWLS-FRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASEN 143
Cdd:cd17378 40 SSFFVGCLIGSGVLGHLAdSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 658548708 144 VRGKMISMYQLMVTLGI----VLAFLSDTyfsysgNWRAMLGVLALPALVLIVLVIFLP 198
Cdd:cd17378 120 WRGQVGMSTFFFFVLGFmslpGIAYLNGS------SWRVLYFWTSIPALIYCILVYLFA 172
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
14-197 |
4.41e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 42.68 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 14 LRDTRRMNQFVSIAAAvaGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMV 93
Cdd:pfam13347 217 LKEVFRNRAFLILLAS--FLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYIL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 94 GAILFVAGSIGSAF--AANVEILLLSRVLLGVAVGIASYTAPLYLSEMASEN-------VRGKMISMYQLM----VTLGI 160
Cdd:pfam13347 295 GALITIAGFALALLlgPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGelrtgkrREGTFFAMWSFIsklaTGVGL 374
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 658548708 161 VLAFLSDTYFSY---------SGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:pfam13347 375 GVSGLLLSAFGYnagdsvqspQAVTAIRLLYAVLPAVLFLVALLLL 420
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
62-196 |
5.66e-04 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 42.20 E-value: 5.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLG-RKYSLMVGAILFVAGSIGSAFAANVE-----ILLLSRVLLGVAVGIASYTAPlY 135
Cdd:cd17326 40 WVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPsnrkyVMLVARFLIGVGAGNVAVLRA-Y 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 136 LSEMASENVRGKMISMYQLMVTLGIVL------AFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIF 196
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVgpalqaAFTPIGYPGYVIGIKLRFNMYTAPAWLMAILGII 185
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
25-190 |
5.90e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 25 SIAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIG 104
Cdd:cd17477 190 APLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 105 SAFAANVEILLLsrVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTL-------GIVLAFLSDTYFSYSGNWR 177
Cdd:cd17477 270 LPLVPGLPLALL--VLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLyglgsviGPLLAGALMDAFGPHGLFL 347
|
170
....*....|...
gi 658548708 178 AMLGVLALPALVL 190
Cdd:cd17477 348 FLAAVALLFLLFL 360
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
69-198 |
6.42e-04 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 41.64 E-value: 6.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 69 LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAV-GIASYTAPLYLS--EMASENVR 145
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALtGFSIISMVLCVEwvDIEHRTVA 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 658548708 146 GKMISM-YQLMVTLGIVLAFLSDtyfsysgNWRAMLGVLALPALVLIVLVIFLP 198
Cdd:cd17447 126 GVLISLfWTVGNMLLALVAYLIR-------DWRWLILAVTLPCAPGIITWWWVP 172
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
79-222 |
6.95e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 41.74 E-value: 6.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 79 GWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTL 158
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658548708 159 GIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFlpNSPRWLAQKGRHVEAEEVLRMLRD 222
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLL--AMPETVKRGAVPFSAKSVLRDFRN 213
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
62-201 |
8.03e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 41.80 E-value: 8.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIgalfngwLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVllGVAVGIA---SYTAPLYLsE 138
Cdd:PRK03545 55 WVVALMSLPLML-------LTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRI--GIAFAHAifwSITASLAI-R 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 658548708 139 MASENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVI-FLPNSP 201
Cdd:PRK03545 125 VAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIkLLPLLP 188
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
72-197 |
1.06e-03 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 41.11 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 72 AIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAA------NVEILLLSRVLLGVAVGIASY--TAPLYLSEMASEN 143
Cdd:cd17386 44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVyfttvpSVWWFYLSAIPLALFGGFTAFlsASFAYISDISSEK 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 658548708 144 VRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAML---GVLALPALVLIVLVIFL 197
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFsisAALLLIALLYILFFLTL 180
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
62-197 |
1.47e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMA- 140
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAr 333
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 658548708 141 SENVRGKMISMYQLMVTLGIVLA-FLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFL 197
Cdd:COG2807 334 TPAEAAALSGMAQSVGYLLAALGpLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
26-203 |
1.77e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPF---ITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGS 102
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFiipIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 103 IGSAFAANV-EILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMISMYQLMVTLG-IVLAFLSDTYFSYSGnWRAML 180
Cdd:cd17355 83 VLLALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGsLVFLPLGAALIEAFG-WRTAL 161
|
170 180
....*....|....*....|...
gi 658548708 181 GVLALPALVLIVLVIFLPNSPRW 203
Cdd:cd17355 162 LVLALLALLVLVPVLLLLRRRPA 184
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-190 |
1.85e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 28 AAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLG---RKYSLMVGAILFVAGSIG 104
Cdd:cd17475 204 AIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLVITAAIAAAALLV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 105 SAFAANVEILLLSRVLLGVAVGIASYTAPLYL---SEMASENVRGKMISMYQLMVTLGIVLA-----FLSDTYFSYSGNW 176
Cdd:cd17475 284 LSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLtlvAESAGPEQAGTALGLANTINFIGIAIGpplfgLLVDATHSYAPAW 363
|
170
....*....|....
gi 658548708 177 RAMLGVLALPALVL 190
Cdd:cd17475 364 LALALLLVLAALLL 377
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
68-186 |
2.30e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 40.14 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 68 MLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRgK 147
Cdd:cd17445 46 ILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQR-L 124
|
90 100 110
....*....|....*....|....*....|....*....
gi 658548708 148 MISMYQLMVTLGIVLAFLSDTYfsYSGNWRAMLGVLALP 186
Cdd:cd17445 125 LVAMAGGLTMVGGHFLLLGLAL--GCGSWRVLQGTITAP 161
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
33-194 |
2.36e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.02 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 33 LLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVE 112
Cdd:cd17396 10 FVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 113 ILLLSRVLLGVA---VGIASYTA--PLYLSEMASENVRGK-MISMYQLMvtLGIVLAFLSDTYFSYSGNWRAMLGVLALP 186
Cdd:cd17396 90 IAYVFALLAGAAnsfLDTGTYPAlmEAFPKASGSANILVKaFVSFGQFL--LPFIIAFLAANNLWYGWSFIVPAAVLVLN 167
|
....*...
gi 658548708 187 ALVLIVLV 194
Cdd:cd17396 168 ALLLLKLS 175
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-196 |
2.78e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 106 AFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMASENVRGKMI-SMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLA 184
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVfSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160
|
170
....*....|..
gi 658548708 185 LPALVLIVLVIF 196
Cdd:cd17476 161 ILAAIVAVAAIF 172
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
62-211 |
2.98e-03 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 39.70 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 62 WVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLYLSEMAS 141
Cdd:cd17410 38 LLTVLPVLCMGLVALLGPWLARRVGERRGVALSLLAIAAACLWRLWSGTGPTLIASALLGGLGIAIIQALVPGLIKRRFP 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658548708 142 ENVRGKMISMYQLMVTLGIVLAFLSDTYFSYSGNWRAMLGVLALPALVLIVLVIFLPNS---PRWLAQKGRHV 211
Cdd:cd17410 118 ARVPLAMGLYSASLMAGGGLAASLSPRLAQHSAGWQLGLGIWAVPALVALVLWWRQPPRevaPSDTAGPGVRF 190
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
26-126 |
3.62e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 26 IAAAVAGLLFGLDIGVIAGALPFITDHFTLSNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGS 105
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100
....*....|....*....|.
gi 658548708 106 AFAANVEILLLSRVLLGVAVG 126
Cdd:cd17393 82 GLAPSVPALALALFLFGAANG 102
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
69-198 |
4.90e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.37 E-value: 4.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 69 LGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGI---ASYTaplYLSEMASENVR 145
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGiqaLSRS---LLARLIPPGRE 361
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 658548708 146 GKMISMYQLMVTLGIVLAFLSDTYFSY-SGNWRAMLGVLALPALVLIVLVIFLP 198
Cdd:COG2270 362 AEFFGLYALSGKAASFLGPLLFGLVTQlTGSQRLGILSLIVFFVIGLVLLLRVK 415
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
66-198 |
7.28e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 38.41 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 66 SMMLGAAIGALFN----------GWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVAVGIASYTAPLy 135
Cdd:cd17389 62 SVLFGGLIGSLFSllqflsspitGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAI- 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658548708 136 LSEMASENVRGKMISMYQLMVTLGIVL-----AFLSDTYFSYSGNWRAMLGVLAL--PALVLIVLVIFLP 198
Cdd:cd17389 141 VADVTSPKKRSKGMALIGVAFSLGFIIgpmigAYFASFTRSLGEVFFSMPALFALvlALADLLFIFFFLP 210
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
56-124 |
9.57e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.17 E-value: 9.57e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658548708 56 SNRLQEWVVSSMMLGAAIGALFNGWLSFRLGRKYSLMVGAILFVAGSIGSAFAANVEILLLSRVLLGVA 124
Cdd:cd17446 31 HRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMA 99
|
|
| |
