|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
5-486 |
0e+00 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 1004.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 5 LRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNRITVEMPENLNQQSPT 84
Cdd:PRK10815 3 LRHFFPLSLRVRFLLATAAVVLALSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKLSIELPENLDLNSPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 85 LALIYNEKGKLLWAQRDIPWLVKSIRPDWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADNAETEMTHSVAINLY 164
Cdd:PRK10815 83 LVLIYDENGKLLWRQRDVPWLEKMIQPEWLKKNGFHEIETDVNDSSLLLSGDHSAQQQLKEVREDDDDAEMTHSVAVNVY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 165 PATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETT 244
Cdd:PRK10815 163 PATSRLPKLTIVVVDTIPQELQRSYMVWSWFSYVLLANLLLVIPLLWLAAWWSLRPIEALAKQVRELEEGEREQLDPNPP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 245 RELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSK-LSVDDAEPVMLEQISRISQQIGYYLH 323
Cdd:PRK10815 243 RELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEPIMLEQISRISQQIGYYLH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 324 RASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSA 403
Cdd:PRK10815 323 RASMRSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 404 RQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQQPT 483
Cdd:PRK10815 403 RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHST 482
|
...
gi 658547338 484 LND 486
Cdd:PRK10815 483 PKD 485
|
|
| PhoQ_Sensor |
pfam08918 |
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria ... |
10-189 |
1.26e-104 |
|
PhoQ Sensor; The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognizes divalent metal cations, and antimicrobial cationic peptides (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 430316 Cd Length: 179 Bit Score: 309.66 E-value: 1.26e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 10 PLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNRITVEMPENLNQQSPTLALIY 89
Cdd:pfam08918 1 PFSLRTRFLLATAAVVLALSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYSLAQWDDNKLTIAVPPNLDLNSPTLVLIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 90 NEKGKLLWAQRDIPWLVKSIRPDWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADNAeTEMTHSVAINLYPATLN 169
Cdd:pfam08918 81 DENGKLLWRQRHVPELEKHIKPEWLKKNGFYELDTDTDTSSALLGNNPLAQDQLKAINDDDD-NELTHSVAVNRYPATSR 159
|
170 180
....*....|....*....|
gi 658547338 170 MPQLTIVVIDTIPVELKRSY 189
Cdd:pfam08918 160 LPALTIVVVDTIPQELQRSD 179
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-477 |
1.78e-79 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 243.69 E-value: 1.78e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIP 422
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 658547338 423 RNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16954 81 ESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
159-477 |
3.13e-38 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 141.97 E-value: 3.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 159 VAINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREK 238
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 239 LNPETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSkLSVDDAEPV--MLEQISRISQ 316
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLetILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 317 QIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYC 395
Cdd:COG0642 160 LINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 396 LE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGV--GLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:COG0642 240 PEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*.
gi 658547338 472 RMEVIF 477
Cdd:COG0642 320 TFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
250-477 |
8.85e-38 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 138.12 E-value: 8.85e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 250 LVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEPVMLEQIS----RISQQIGYYLHRA 325
Cdd:COG2205 2 LEEALEELEELERLK----SEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIResaeRLLRLIEDLLDLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 326 SMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPE-ISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVS 402
Cdd:COG2205 78 RLESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPggTITIS 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547338 403 ARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
160-477 |
1.79e-33 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 130.44 E-value: 1.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 160 AINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKL 239
Cdd:COG5002 53 ALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 240 NPETTRELTSLVRNLNRLLK---SERERYDKYRTTLT-DLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEP----VMLEQI 311
Cdd:COG5002 133 RLSLRLSALLLGLLLLAAVErdiTELERLEQMRREFVaNVSHELRTPLTSIRGYLELLLDGAADDPEERReyleIILEEA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 312 SRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDN 390
Cdd:COG5002 213 ERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVlGDPDRLEQVLTNLLDN 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 391 ACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYDGKIETS 464
Cdd:COG5002 293 AIKYTPEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRsretGGTGLGLAIVKHIVEAHGGRIWVE 372
|
330
....*....|...
gi 658547338 465 ESLLGGARMEVIF 477
Cdd:COG5002 373 SEPGKGTTFTITL 385
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
375-477 |
4.84e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 99.26 E-value: 4.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 375 GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRAD---TLRPGQGVGLAV 449
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*...
gi 658547338 450 AREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
380-477 |
1.21e-23 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 94.98 E-value: 1.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 380 FMEVMGNLLDNACKYCLEF--VEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVD 455
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGgtIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRegGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 658547338 456 QYDGKIETSESLLGGARMEVIF 477
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
193-477 |
2.06e-20 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 93.54 E-value: 2.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 193 SWFIYVLAAnlLLVIPLLWVAAWWSLRPIESLakevreLEEHHREKLNPETTR-------ELTSLVRNLNRLL----KSE 261
Cdd:PRK10549 166 SWLIVALST--LLAALATFLLARGLLAPVKRL------VEGTHKLAAGDFTTRvtptsrdELGRLAQDFNQLAstleKNE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 262 RERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRssklsvDDAEPVMLEQISRISQQIGYY------LHRASMRSGSALLS 335
Cdd:PRK10549 238 QMR----RDFMADISHELRTPLAVLRGELEAIQ------DGVRKFTPESVASLQAEVGTLtklvddLHQLSLSDEGALAY 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 336 RELH-PVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETELHI 412
Cdd:PRK10549 308 RKTPvDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSggSLHISAEQRDKTLRL 387
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658547338 413 IVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:PRK10549 388 TFADSAPGVSDEQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
375-477 |
3.89e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 85.50 E-value: 3.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 375 GEKNDFMEVMGNLLDNACKYCLEFVEVSAR-QTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR-PGQGVGLAVARE 452
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*
gi 658547338 453 IVDQYDGKIETSESLLGGARMEVIF 477
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTL 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
236-482 |
1.30e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 92.41 E-value: 1.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 236 REKLNPETTREL---TSLVRN-LNRL----------LKSERERYdkyRTTL-TDLTHSLKTPLAVMqstlrsmrssklsV 300
Cdd:PRK10490 620 RQLMIPEQQRLLetfTLLIANaLERLtltaseeqarLASEREQL---RNALlAALSHDLRTPLTVL-------------F 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 301 DDAEPVML----------EQISRISQQI-------GYYLHRASMRSGSALLSRELHPvaplLDNLT-SALNKV-YQRKGV 361
Cdd:PRK10490 684 GQAEILTLdlasegsphaRQASEIRQQVlnttrlvNNLLDMARIQSGGFNLRKEWLT----LEEVVgSALQMLePGLSGH 759
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 362 NISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVE--VSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRAD- 437
Cdd:PRK10490 760 PINLSLPEPLTLIHVDGPLFErVLINLLENAVKYAGAQAEigIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNk 839
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 658547338 438 -TLRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIFGRQQP 482
Cdd:PRK10490 840 eSAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETP 885
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
343-477 |
2.00e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 89.91 E-value: 2.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 343 PLLDNLTSALNKVYQRKGVNISLDISPEISFVGEK-NDFMEVMGNLLDNACKYCLE------FVEVSARQTETELHIIVE 415
Cdd:COG3290 244 PVLAALLLGKAARARERGIDLTIDIDSDLPDLPLSdTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVE 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658547338 416 DDGPGIPRNKRDVVFDRGQRadT-LRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG3290 324 DSGPGIPEELLEKIFERGFS--TkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
200-477 |
2.05e-19 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 90.41 E-value: 2.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 200 AANLLLVIPLLWV--AAWWSLRPIESLAKEVRE-LEEHHREKLNPETTRELTSLVR--------------NLNRLLKSER 262
Cdd:COG5000 118 AAERLLGIPLEELigKPLEELLPELDLAELLREaLERGWQEEIELTRDGRRTLLVRasplrddgyvivfdDITELLRAER 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 263 erydkyRTTLTD----LTHSLKTPLAVMQSTLRSMRS--SKLSVDDAEP------VMLEQISRISQQIGYYLHRASMRSg 330
Cdd:COG5000 198 ------LAAWGElarrIAHEIKNPLTPIQLSAERLRRklADKLEEDREDleraldTIIRQVDRLKRIVDEFLDFARLPE- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 331 salLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTE 407
Cdd:COG5000 271 ---PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKNAIEAIEEggEIEVSTRRED 347
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547338 408 TELHIIVEDDGPGIPRNKRDVVFDrgqradtlrP-------GQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG5000 348 GRVRIEVSDNGPGIPEEVLERIFE---------PffttkpkGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
203-472 |
2.75e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 90.29 E-value: 2.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 203 LLLVIPLLWVAA--WWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLlkseRERYD------KYRTTLTd 274
Cdd:PRK11100 190 LLLGIALLIGAGvvWWLNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELAQALESM----RVKLEgkayveQYVQTLT- 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 275 ltHSLKTPLAVMQSTLRSMRSSkLSVDDAEPVM---LEQISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSA 351
Cdd:PRK11100 265 --HELKSPLAAIRGAAELLQED-PPPEDRARFTgniLTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEA 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 352 LNKVYQRKGVNISLDIsPEISFVGEKNDFMEVMGNLLDNAckycLEF------VEVSARQTETELHIIVEDDGPGIPRNK 425
Cdd:PRK11100 342 REAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNA----IDFspeggtITLSAEVDGEQVALSVEDQGPGIPDYA 416
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 658547338 426 RDVVFDRG---QRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK11100 417 LPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-476 |
3.14e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 80.06 E-value: 3.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 384 MGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYDG 459
Cdd:cd16949 5 LENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHGG 84
|
90
....*....|....*..
gi 658547338 460 KIETSESLLGGARMEVI 476
Cdd:cd16949 85 KIKASNRKPGGLRVRIW 101
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-482 |
1.69e-17 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 84.84 E-value: 1.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 1 MRRILRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNRITVEMPENLNQ 80
Cdd:COG4251 22 LLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 81 QSPTLALIYNEKGKLLWAQRDIPWLVKSIRPDWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADNAETEMTHSVA 160
Cdd:COG4251 102 LLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 161 INLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN 240
Cdd:COG4251 182 LLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLEL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 241 PETTRELTSLVRNLNRllkSERErydkyrttLTDLTHS----LKTPLAVMQS---TLRSMRSSKLSvDDAepvmLEQISR 313
Cdd:COG4251 262 EELEEELEERTAELER---SNEE--------LEQFAYVashdLREPLRKISGfsqLLEEDYGDKLD-EEG----REYLER 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 314 ISQQIgyylHRASM---------RSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEIsfVGEKNDFMEVM 384
Cdd:COG4251 326 IRDAA----ERMQAliddllaysRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTV--RGDPTLLRQVF 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 385 GNLLDNACKYCLE----FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQR--ADTLRPGQGVGLAVAREIVDQYD 458
Cdd:COG4251 400 QNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVERHG 479
|
490 500
....*....|....*....|....*
gi 658547338 459 GKIeTSESLLG-GARMEVIFGRQQP 482
Cdd:COG4251 480 GRI-WVESEPGeGATFYFTLPKAPA 503
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-472 |
2.49e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 77.47 E-value: 2.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR----PGQGVGLAVAREIVDQYD 458
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRdratGGFGLGLAIVHRVALWHG 83
|
90
....*....|....
gi 658547338 459 GKIETSESLLGGAR 472
Cdd:cd16939 84 GHVECDDSELGGAC 97
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
199-475 |
4.26e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 83.44 E-value: 4.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 199 LAANLLLVIPLLWVAAWwslrpieSLAKEVRELEEHHRE------KLNPET---TRELTSLVRNLNRLLKSERERYDKYR 269
Cdd:PRK09470 172 LLVTMLVSTPLLLWLAW-------SLAKPARKLKNAADEvaqgnlRQHPELetgPQEFRQAGASFNQMVTALERMMTSQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 270 TTLTDLTHSLKTPLAVMQSTLRSMR-----SSKLSVDDAEpvmleqISRISQQIGYYLHRASMRSGSALlSRELHPVAPL 344
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRrrqgeSKELERIETE------AQRLDSMINDLLVLSRNQQKNHL-ERETFKANSL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 345 LDN-LTSALNKVYQRkgvNISLDIS--PEISFV-GEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPG 420
Cdd:PRK09470 318 WSEvLEDAKFEAEQM---GKSLTVSapPGPWPInGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPG 394
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 658547338 421 IPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGARMEV 475
Cdd:PRK09470 395 VPEEEREQIFRPFYRVDEARDresgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTI 453
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-477 |
2.26e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 72.11 E-value: 2.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 380 FMEVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREI 453
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....
gi 658547338 454 VDQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
253-472 |
2.89e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 77.72 E-value: 2.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 253 NLNRLLKSererydkyRTTLTD-LTHSLKTPLAVMQSTLrSMrSSKLSvdDAEPVMLEQ-ISRISQQIGYYLHRASmrsg 330
Cdd:PRK10604 204 NINALIAS--------KKQLIDgIAHELRTPLVRLRYRL-EM-SDNLS--AAESQALNRdIGQLEALIEELLTYAR---- 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 331 salLSR---ELHPVAPLLDN-LTSALNKVYQ-RKGVNISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVEVSAR 404
Cdd:PRK10604 268 ---LDRpqnELHLSEPDLPAwLSTHLADIQAvTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLL 344
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658547338 405 QTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK10604 345 LDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDratgGCGLGLAIVHSIALAMGGSVNCDESELGGAR 416
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
196-477 |
3.91e-15 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 76.76 E-value: 3.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 196 IYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLLKSERERydkyRTTLTDL 275
Cdd:COG4191 58 LLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEEL----RELQEQL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 276 THS----------------LKTPLAVMQSTLRSMRSSKLSVDDAEPV------MLEQISRISQQIgyylhrASMRSGSAL 333
Cdd:COG4191 134 VQSeklaalgelaagiaheINNPLAAILGNAELLRRRLEDEPDPEELrealerILEGAERAAEIV------RSLRAFSRR 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 334 LSRELHPV--APLLDNLTSALNKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACkYCLE-----FVEVSARQ 405
Cdd:COG4191 208 DEEEREPVdlNELIDEALELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAI-DAMEegeggRITISTRR 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658547338 406 TETELHIIVEDDGPGIPRNKRDVVFD-------RGQradtlrpGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG4191 287 EGDYVVISVRDNGPGIPPEVLERIFEpffttkpVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
40-477 |
8.91e-15 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 76.21 E-value: 8.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 40 YSVSFDKTTFRLLRGESNLFYTLAKWENNRITVEMPENLNQQSPTLALIYNEKGKLLWAQRDIPWLVKSIRPDWLKTNGF 119
Cdd:COG2972 4 SLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 120 HEIEADLNTTSSLIREDRSLQQKLNEIRADNAETEMTHSVAINLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVL 199
Cdd:COG2972 84 LLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLII 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 200 AANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETTRELTSLVRNLNRLLkserERYDKYRTTLTDLTHSL 279
Cdd:COG2972 164 LLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMV----ERIKELIEEVYELELEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 280 K-TPLAVMQS---------TLRSMRSSKLSVDDaepvmlEQISRISQQIGYYLhRASMRSGSAL--LSRELHPVAPLLdn 347
Cdd:COG2972 240 KeAELKALQAqinphflfnTLNSIRWLAELEDP------EEAEEMLEALSKLL-RYSLSKGDELvtLEEELELIKSYL-- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 348 ltsALNKVYQRKGVNISLDISPEIsfvgekndfMEVM------GNLLDNACKYCLE------FVEVSARQTETELHIIVE 415
Cdd:COG2972 311 ---EIQKLRFGDRLEVEIEIDEEL---------LDLLipklilQPLVENAIEHGIEpkegggTIRISIRKEGDRLVITVE 378
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658547338 416 DDGPGIPRNKRDVVFdrgQRADTLRPGQGVGLAVAREIVDQYDGK---IETSESLLGGARMEVIF 477
Cdd:COG2972 379 DNGVGMPEEKLEKLL---EELSSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRI 440
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-475 |
1.02e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 70.01 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLEF------VEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRG--QRADTLRpgqGVGLAVAREIV 454
Cdd:cd16915 4 IVGNLIDNALDALAATgapnkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGvsTKGQGER---GIGLALVRQSV 80
|
90 100
....*....|....*....|.
gi 658547338 455 DQYDGKIETSESLLGGARMEV 475
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSI 101
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
204-477 |
1.80e-14 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 75.33 E-value: 1.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 204 LLVIPLLWVA-AWWSLR----PIESL---AKEVRELEehHREKLNPETTRELTSLVRNLNRLLKSERERYDKyRTTLT-D 274
Cdd:PRK09467 159 TLAIGLLSVAgGWLFIRiqnrPLVALehaALQVGKGE--IPPPLREYGASEVRSVTRAFNQMAAGIKQLEDD-RTLLMaG 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 275 LTHSLKTPLavmqsTLRSMRSSKLSVDDAepVMLEQISR--------ISQQIGYylhrasMRSGSALlSRELHPVAPLLD 346
Cdd:PRK09467 236 VSHDLRTPL-----TRIRLATEMMSEEDG--YLAESINKdieecnaiIEQFIDY------LRTGQEM-PMEMADLNALLG 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 347 NLTSALNKvYQRKgvnISLDISPeisfvGEKNDFME------VMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPG 420
Cdd:PRK09467 302 EVIAAESG-YERE---IETALQP-----GPIEVPMNpiaikrALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPG 372
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 658547338 421 IPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:PRK09467 373 IPPEQLKHLFQPFTRGDSARgsSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-474 |
1.17e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 66.70 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLEFVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGK 460
Cdd:cd16950 4 VLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARgtSGTGLGLAIVQRISDAHGGS 83
|
90
....*....|....*.
gi 658547338 461 IETSESLLGG--ARME 474
Cdd:cd16950 84 LTLANRAGGGlcARIE 99
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
228-461 |
6.71e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 66.90 E-value: 6.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 228 VRELEEHHREKlNPETTRELTSLVRNLNRL--LKSERErydkyrtTLTD-----------LTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK09303 106 YSGLGENLQPS-EIDSGRYSQELLQLSDELfvLRQENE-------TLLEqlkfkdrvlamLAHDLRTPLTAASLALETLE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 295 S-SKLSVDDAEPVMLEQ-----------ISRISQQIgyyLHRASMRSgSALlsrELHPV----APLLDNLTSALNKVYQR 358
Cdd:PRK09303 178 LgQIDEDTELKPALIEQlqdqarrqleeIERLITDL---LEVGRTRW-EAL---RFNPQkldlGSLCQEVILELEKRWLA 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 359 KGVNISLDISPEISFVGEKNDFM-EVMGNLLDNACKYCLEFVEVSArqteTELH-------IIVEDDGPGIPRNKRDVVF 430
Cdd:PRK09303 251 KSLEIQTDIPSDLPSVYADQERIrQVLLNLLDNAIKYTPEGGTITL----SMLHrttqkvqVSICDTGPGIPEEEQERIF 326
|
250 260 270
....*....|....*....|....*....|....
gi 658547338 431 D---RGQRADTlRPGQGVGLAVAREIVDQYDGKI 461
Cdd:PRK09303 327 EdrvRLPRDEG-TEGYGIGLSVCRRIVRVHYGQI 359
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-475 |
7.74e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 62.04 E-value: 7.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 382 EVMGNLLDNACKYCLEFVEVSARQTETEL-HIIVEDDGPGIPRNKRDVVFDRGQRAD-TLRPGQGVGLAVAREIVDQYDG 459
Cdd:cd16940 16 LLLRNLVDNAVRYSPQGSRVEIKLSADDGaVIRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVKRIVELHGG 95
|
90
....*....|....*.
gi 658547338 460 KIETSESLLGGARMEV 475
Cdd:cd16940 96 QIFLGNAQGGGLEAWV 111
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
381-470 |
1.41e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.19 E-value: 1.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 381 MEVMGNLLDNACKYCLEF----VEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIV 454
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREeyEGTGVGLAIVRKII 81
|
90
....*....|....*.
gi 658547338 455 DQYDGKIeTSESLLGG 470
Cdd:cd16921 82 ERHGGRI-WLESEPGE 96
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
199-460 |
5.10e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 64.22 E-value: 5.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 199 LAANLLLVIPLLWVAAW---WSLRPIESLAKEvreLEEHHREKLNP----ETTRELTSLVRNLNRLLKSERERYDKYRTT 271
Cdd:PRK10755 64 LVPSLVMVSLTLLICFQavrWITRPLAELQKE---LEARTADNLTPiaihSSTLEIEAVTSALNQLVSRLTSTLDQERLF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 272 LTDLTHSLKTPLAVMQSTLRSMrsSKLSVDDAEPvMLEQISRISQQIGYYLHRAsmRSGSALLSRELHPVApLLDN---- 347
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLELL--EKQHHIDVAP-LIARLDQMMHTVEQLLQLA--RAGQSFSSGHYQTVK-LLEDvilp 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 348 LTSALNKVYQRKGVNISLDISP-EISFVGEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRN 424
Cdd:PRK10755 215 SQDELSEMLEQRQQTLLLPESAaDITVQGDATLLRLLLRNLVENAHRYSPEgsTITIKLSQEDGGAVLAVEDEGPGIDES 294
|
250 260 270
....*....|....*....|....*....|....*.
gi 658547338 425 KRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGK 460
Cdd:PRK10755 295 KCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQ 330
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
219-472 |
1.62e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 63.77 E-value: 1.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 219 RPIESLAKEVRELEeHHREKLNPET---TRELTSLVRNlNRLLKSERERYDKYRTT-LTDLTHSLKTPLAVMQSTLRSMR 294
Cdd:PRK11466 393 RLMDAFRSNVHALN-RHREQLAAQVkarTAELQELVIE-HRQARAEAEKASQAKSAfLAAMSHEIRTPLYGILGTAQLLA 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 295 SSKLS---------VDDAEPVMLEQISRIsqqigyyLHRASMRSGSALLSRELHPVAP--LLDNLTSALNKVYQRKGVNI 363
Cdd:PRK11466 471 DNPALnaqrddlraITDSGESLLTILNDI-------LDYSAIEAGGKNVSVSDEPFEPrpLLESTLQLMSGRVKGRPIRL 543
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 364 SLDISPEI--SFVGEKNDFMEVMGNLLDNACKYCLE-FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR 440
Cdd:PRK11466 544 ATDIADDLptALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR 623
|
250 260 270
....*....|....*....|....*....|..
gi 658547338 441 PGQGVGLAVAREIVDQYDGKIETSESLLGGAR 472
Cdd:PRK11466 624 GGTGLGLTISSRLAQAMGGELSATSTPEVGSC 655
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
150-467 |
2.06e-10 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 62.87 E-value: 2.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 150 NAETEMTHS----VAINLYPATLNMPQLTIVVIDTIPV------ELKRSYMVWSWFIYvlaanlLLVIPLLWVAAWWSLR 219
Cdd:PRK09835 138 HGHGHMEHSnwrmIALPVGPLVDGKPIYTLLIALSIDFhlhyinDLKNKLIMTASVIS------LLIVFIVLLAVHKGHA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 220 PIESLAKEVREL-EEHHREKLNPETTR-ELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLA--VMQS--TLRSM 293
Cdd:PRK09835 212 PIRSVSRQIQNItSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlITQTeiALSQS 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 294 RSSKlsvdDAEPVM---LEQISRISQQIGYYLHRASMRSgsallsRELHPVAPLLDnLTSALNKVY-------QRKGVNI 363
Cdd:PRK09835 292 RSQK----ELEDVLysnLEELTRMAKMVSDMLFLAQADN------NQLIPEKKMLD-LADEVGKVFdffeawaEERGVEL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 364 SLDISPeISFVGEKNDFMEVMGNLLDNACKYCL--EFVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR- 440
Cdd:PRK09835 361 RFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPagEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRq 439
|
330 340 350
....*....|....*....|....*....|
gi 658547338 441 ---PGQGVGLAVAREIVDQYDGKIETSESL 467
Cdd:PRK09835 440 rkgEGSGIGLAIVKSIVVAHKGTVAVTSDA 469
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
233-472 |
8.37e-10 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 60.79 E-value: 8.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 233 EHHRE-KLNPETTRELTSLVRNLNRLLKSERERydkyRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLS---VDDAEPVML 308
Cdd:PRK11006 172 GRHLEiRVMPYTEGQLLMVARDVTQMHQLEGAR----RNFFANVSHELRTPLTVLQGYLEMMQDQPLEgalREKALHTMR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 309 EQISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGvNISLDISPEISFVGEKNDFMEVMGNLL 388
Cdd:PRK11006 248 EQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKH-TITFEVDNSLKVFGNEDQLRSAISNLV 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 389 DNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDGKIE 462
Cdd:PRK11006 327 YNAVNHTPEgtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqtgGSGLGLAIVKHALSHHDSRLE 406
|
250
....*....|
gi 658547338 463 TSESLLGGAR 472
Cdd:PRK11006 407 IESEVGKGTR 416
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-461 |
1.58e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.60 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQ 456
Cdd:cd16947 24 ILKNLISNAIKYGSDgkFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGLGLTITKRLAES 103
|
....*
gi 658547338 457 YDGKI 461
Cdd:cd16947 104 MGGSI 108
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-461 |
1.65e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.27 E-value: 1.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 382 EVMGNLLDNACKYCLEF---VEVSARQTETELHIIVEDDGPGIPRNKRDVVFDR--GQRADTLRPGQ--GVGLAVAREIV 454
Cdd:cd16953 3 QVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRfyTERPANEAFGQhsGLGLSISRQII 82
|
....*..
gi 658547338 455 DQYDGKI 461
Cdd:cd16953 83 EAHGGIS 89
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
383-465 |
1.73e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 55.19 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLE---FVEVSARQTETE---LHIIVEDDGPGIPRNKRDVVFDRGQRAD--TLRP--GQGVGLAVARE 452
Cdd:cd16922 4 ILLNLLGNAIKFTEEgevTLRVSLEEEEEDgvqLRFSVEDTGIGIPEEQQARLFEPFSQADssTTRKygGTGLGLAISKK 83
|
90
....*....|....
gi 658547338 453 IVDQYDGKIE-TSE 465
Cdd:cd16922 84 LVELMGGDISvESE 97
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
362-469 |
2.73e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.16 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 362 NISLDIS-----PEISFVGEKNDFMEVMGNLLDNAckycLEFV--------EVSARQTETELHIIVEDDGPGIPRNKRDV 428
Cdd:PRK11086 411 GITLIISedsqlPDSGDEDQVHELITILGNLIENA----LEAVggeeggeiSVSLHYRNGWLHCEVSDDGPGIAPDEIDA 486
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 658547338 429 VFDRGqrADTLRPGQGVGLAVAREIVDQYDGKIETsESLLG 469
Cdd:PRK11086 487 IFDKG--YSTKGSNRGVGLYLVKQSVENLGGSIAV-ESEPG 524
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-462 |
5.50e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 53.62 E-value: 5.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 384 MGNLLDNACKYCLEF--VEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRG---QRADTLRPGQGVGLAVAREIVDQYD 458
Cdd:cd16945 9 INNLLDNAIDFSPEGglIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQKSTGLGLAFVQEVAQLHG 88
|
....
gi 658547338 459 GKIE 462
Cdd:cd16945 89 GRIT 92
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
199-453 |
6.37e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 58.12 E-value: 6.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 199 LAANLLLVIPLLWVAaWWSLRPIESLAKEVRELEEHHREKLNPETT-RELTSLVRNLNRLLKS-----ERERydkyRTTl 272
Cdd:PRK10337 168 LVALPIMLIILMVLL-GRELAPLKKLALALRMRDPDSETPLNATGVpSEVRPLVEALNQLFARthammVRER----RFT- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 273 TDLTHSLKTPLAVM--QSTLrsmrsSKLSVDDaePVMLEQ--------ISRISQQIGYYLHRASMRSGSALlsRELHPVa 342
Cdd:PRK10337 242 SDAAHELRSPLAALkvQTEV-----AQLSDDD--PQARKKallqlhagIDRATRLVDQLLTLSRLDSLDNL--QDVAEI- 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 343 PLLDNLTSALNKVY---QRKGVNISLDI-SPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTETELHiiVEDDG 418
Cdd:PRK10337 312 PLEDLLQSAVMDIYhtaQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFT--VRDNG 389
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 658547338 419 PGIPRNKRDVVFDR-----GQRAdtlrPGQGVGLAVAREI 453
Cdd:PRK10337 390 PGVTPEALARIGERfyrppGQEA----TGSGLGLSIVRRI 425
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
347-462 |
7.49e-09 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 57.55 E-value: 7.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 347 NLTSALNKVYQ------RKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACK------------YCLEFVEVSARQTE 407
Cdd:COG3852 205 NLHEVLERVLEllraeaPKNIRIVRDYDPSLPEVlGDPDQLIQVLLNLVRNAAEampeggtitirtRVERQVTLGGLRPR 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 408 TELHIIVEDDGPGIPRNKRDVVFD-----RGQradtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:COG3852 285 LYVRIEVIDNGPGIPEEILDRIFEpffttKEK-------GTGLGLAIVQKIVEQHGGTIE 337
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
383-475 |
1.08e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 52.88 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLEFVEVSARQTETELH---IIVEDDGPGIPRNKRDVVFDRGQRADTL----RPGQGVGLAVAREIVD 455
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIRCILEKFRLNrflLTVSDSGPGIPPNLREEIFERFRQGDGSstraHGGTGLGLSIVKEFVE 87
|
90 100
....*....|....*....|
gi 658547338 456 QYDGKIETSESLLGGARMEV 475
Cdd:cd16925 88 LHGGTVTVSDAPGGGALFQV 107
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
383-462 |
2.47e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 51.62 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 383 VMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYD 458
Cdd:cd16923 4 VFSNLLSNAIKYSPEntRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRntEGAGLGLSIAKAIIELHG 83
|
....
gi 658547338 459 GKIE 462
Cdd:cd16923 84 GSAS 87
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-464 |
2.70e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 52.58 E-value: 2.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 357 QRKGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLE------FVEVSARQTETELHIIVEDDGPGIPRNKRDvvF 430
Cdd:cd16935 14 REKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAKidkenrFIHLKIRQKKGFLIISIENSYEGELKKKNG--L 91
|
90 100 110
....*....|....*....|....*....|....
gi 658547338 431 DRGQRADTLRpgqGVGLAVAREIVDQYDGKIETS 464
Cdd:cd16935 92 FLSTKKDKNH---GIGLKSIREIVKKYNGNLSIE 122
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-476 |
3.60e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 51.27 E-value: 3.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 382 EVMGNLLDNACKYCLEFVEVSAR--QTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDG 459
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRtwAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGG 85
|
90
....*....|....*..
gi 658547338 460 KIETSESLLGGARMEVI 476
Cdd:cd16943 86 TIRVASVPGGGTRFTII 102
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-481 |
3.77e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 51.43 E-value: 3.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 386 NLLDNACKYCLEFVEVSAR--QTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRP----GQGVGLAVAREIVDQYDG 459
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHVMSRHDA 86
|
90 100
....*....|....*....|..
gi 658547338 460 KIETSESLLGGARMEVIFGRQQ 481
Cdd:cd16952 87 RLLIASELGKGSRFTCLFPSSR 108
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
277-462 |
9.38e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 54.35 E-value: 9.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 277 HSLKTPLAVMQSTLRSMRSSKLSVDDAEPVMLEQISRISQQIGYYLHRASMRSGS---ALLSRELHPVAPLLdnLTSALN 353
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNkekENINELIQDVVTLL--ETEAIL 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 354 KvyqrkGVNISLDISPEISFV-GEKNDFMEVMGNLLDNAckycLE------FVEVSARQTETELHIIVEDDGPGIPRNkr 426
Cdd:COG5805 374 H-----NIQIRLELLDEDPFIyCDENQIKQVFINLIKNA----IEampnggTITIHTEEEDNSVIIRVIDEGIGIPEE-- 442
|
170 180 190
....*....|....*....|....*....|....*...
gi 658547338 427 dvVFDR-GQRADTLR-PGQGVGLAVAREIVDQYDGKIE 462
Cdd:COG5805 443 --RLKKlGEPFFTTKeKGTGLGLMVSYKIIENHNGTID 478
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-477 |
1.01e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 50.23 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 382 EVMGNLLDNACKYCLEF--------VEVSARQtETELHIIVEDDGPGIPRNKRDVVFDrgQRADTLRPGQGVGLAVAREI 453
Cdd:cd16944 7 QVLTNILKNAAEAIEGRpsdvgevrIRVEADQ-DGRIVLIVCDNGKGFPREMRHRATE--PYVTTRPKGTGLGLAIVKKI 83
|
90 100
....*....|....*....|....
gi 658547338 454 VDQYDGKIETSESLLGGARMEVIF 477
Cdd:cd16944 84 MEEHGGRISLSNREAGGACIRIIL 107
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
355-477 |
1.05e-07 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 54.20 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 355 VYQRKGVNISLDISPEISFVGEKNDFME-VMGNLLDNACKYCLEFVEVSAR---QTETELHIIVEDDGPGIPRNKRDVVF 430
Cdd:PRK11360 475 AGVQARVDFETELDNELPPIWADPELLKqVLLNILINAVQAISARGKIRIRtwqYSDGQVAVSIEDNGCGIDPELLKKIF 554
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 658547338 431 DRgqrADTLRP-GQGVGLAVAREIVDQYDGKIETsESLLG-GARMEVIF 477
Cdd:PRK11360 555 DP---FFTTKAkGTGLGLALSQRIINAHGGDIEV-ESEPGvGTTFTLYL 599
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
410-462 |
1.09e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.40 E-value: 1.09e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 658547338 410 LHIIVEDDGPGIPRNKRDVVFDR--GQRADtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:cd16918 44 LRVSVIDNGPGIPPDLQDTIFYPmvSGREN----GTGLGLAIAQNIVSQHGGVIE 94
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
412-462 |
2.61e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 49.31 E-value: 2.61e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 658547338 412 IIVEDDGPGIPRNKRDVVFD---RGQRAdtlrpGQGVGLAVAREIVDQYDGKIE 462
Cdd:PRK11073 283 IDIEDNGPGIPPHLQDTLFYpmvSGREG-----GTGLGLSIARNLIDQHSGKIE 331
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
402-471 |
4.34e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 45.47 E-value: 4.34e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 402 SARQTETELHIIVEDDGPGIPRNKRDVVFDrgQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:cd16920 30 TSPADDRAVTISVKDTGPGIAEEVAGQLFD--PFYTTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
1-477 |
6.10e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 48.75 E-value: 6.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 1 MRRILRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNRITVEMPENLNQ 80
Cdd:COG3920 14 AALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 81 QSPTLALIYNEKGKLLWAQRDIPWLVKSIRPDWLKTNGFHEIEADLNTTSSLIREDRSLQQKLNEIRADNAETEMTHSVA 160
Cdd:COG3920 94 AAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 161 INLYPATLNMPQLTIVVIDTIPVELKRSYMVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLN 240
Cdd:COG3920 174 AAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 241 PETTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSL--------------KTPLAVMQSTLRsMRSSKLSVDDAEPV 306
Cdd:COG3920 254 LLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLeekelllrelhhrvKNNLQVVSSLLR-LQARRADDPEAREA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 307 MLEQISRIsqqigyylhrASMrsgsALLSRELH--------PVAPLLDNLTSALNKVYQRKGVNISLDIsPEISF----- 373
Cdd:COG3920 333 LEESQNRI----------QAL----ALVHELLYqsedwegvDLRDYLRELLEPLRDSYGGRGIRIELDG-PDVELpadaa 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 374 ------VGEkndfmevmgnLLDNACKYCLE-----FVEVSARQTETELHIIVEDDGPGIPRNkrdvvFDRGQRadtlrpg 442
Cdd:COG3920 398 vplgliLNE----------LVTNALKHAFLsgeggRIRVSWRREDGRLRLTVSDNGVGLPED-----VDPPAR------- 455
|
490 500 510
....*....|....*....|....*....|....*
gi 658547338 443 QGVGLAVAREIVDQYDGKIETSESllGGARMEVIF 477
Cdd:COG3920 456 KGLGLRLIRALVRQLGGTLELDRP--EGTRVRITF 488
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-476 |
9.38e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 44.37 E-value: 9.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 382 EVMGNLLDNACKYCLEF----VEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQY 457
Cdd:cd16976 3 QVLMNLLQNALDAMGKVenprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEH 82
|
90
....*....|....*....
gi 658547338 458 DGKIETSESLLGGARMEVI 476
Cdd:cd16976 83 GGRLSVANEEGAGARFTFD 101
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
378-464 |
1.26e-05 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 44.13 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 378 NDFMEVMGNLLDNA---CKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKrDVVFDRGQRADtlrpGQGVGLAVARE 452
Cdd:pfam14501 4 VDLCVIFGNLLDNAieaCSKIDDnrFIRLKIREKQNFLIIRIENTYEGELKFE-GKLPSTKTKGD----GHGIGLKSIRR 78
|
90
....*....|..
gi 658547338 453 IVDQYDGKIETS 464
Cdd:pfam14501 79 IVKKYGGNLSTE 90
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
245-462 |
3.24e-05 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 46.12 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 245 RELTSLVRNLNRLLKSERerYDKYRTTLTDLTHSLKTPLA-------VMQSTLRSMRSSKLSVddaepvMLEQISRISQQ 317
Cdd:COG5809 249 RDITERKKLEELLRKSEK--LSVVGELAAGIAHEIRNPLTslkgfiqLLKDTIDEEQKTYLDI------MLSELDRIESI 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 318 IGYYL-----HRASMRSGSalLSRELHPVAPLLDnlTSALnkvyqRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNA 391
Cdd:COG5809 321 ISEFLvlakpQAIKYEPKD--LNTLIEEVIPLLQ--PQAL-----LKNVQIELELEDDIPDIlGDENQLKQVFINLLKNA 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 392 CKYCLEFVEVSARQTETELHII---VEDDGPGIPRNKRDVVFDrgqradtlrP-------GQGVGLAVAREIVDQYDGKI 461
Cdd:COG5809 392 IEAMPEGGNITIETKAEDDDKVvisVTDEGCGIPEERLKKLGE---------PfyttkekGTGLGLMVSYKIIEEHGGKI 462
|
.
gi 658547338 462 E 462
Cdd:COG5809 463 T 463
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
190-477 |
4.07e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 44.99 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 190 MVWSWFIYVLAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREklnpetTREltslvrnlnrllkSERER----- 264
Cdd:COG4585 1 LLALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEE------ARE-------------EERRRiarel 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 265 YDkyrttltDLTHSLktplAVMQSTLRSMRSSKLSVDDAEPVMLEQISRISQQIGyylhrASMRSgsalLSRELHPVAPL 344
Cdd:COG4585 62 HD-------GVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREAL-----AELRR----LVRGLRPPALD 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 345 LDNLTSAL----NKVYQRKGVNISLDISPEISFVGekndfMEVMGNL-------LDNACKYCL-EFVEVSARQTETELHI 412
Cdd:COG4585 122 DLGLAAALeelaERLLRAAGIRVELDVDGDPDRLP-----PEVELALyrivqeaLTNALKHAGaTRVTVTLEVDDGELTL 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 658547338 413 IVEDDGPGIPRNKrdvvfdrgqradtlRPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEVIF 477
Cdd:COG4585 197 TVRDDGVGFDPEA--------------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
272-461 |
4.58e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 46.27 E-value: 4.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDD-AEPVMLEQISRIS--QQIGYYLHRASMRSGSALLSRELHPVAPLLDNL 348
Cdd:PRK09959 716 LATMSHEIRTPISSIMGFLELLSGSGLSKEQrVEAISLAYATGQSllGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNT 795
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 349 TSALNKVYQRKGVNISLDIS-PEISFVG-EKNDFMEVMGNLLDNACKYClefVEVSARQTETELHI---------IVEDD 417
Cdd:PRK09959 796 CHSFGAIAASKSIALSCSSTfPDHYLVKiDPQAFKQVLSNLLSNALKFT---TEGAVKITTSLGHIddnhavikmTIMDS 872
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 658547338 418 GPGIPRNKRDVVFDRGQRADTLR--PGQGVGLAVAREIVDQYDGKI 461
Cdd:PRK09959 873 GSGLSQEEQQQLFKRYSQTSAGRqqTGSGLGLMICKELIKNMQGDL 918
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
199-473 |
5.62e-05 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 45.79 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 199 LAANLLLVIPLLWVAAWWSLRPIESLAKEVRELEEHHREKLNPETTR-ELTSLVRNLNRLLKSERERYD------KYRTT 271
Cdd:PRK15347 303 LLILVLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLdELGSIAKAYNQLLDTLNEQYDtlenkvAERTQ 382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 272 -------------------LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAEPV---------MLEQI------SRIsqq 317
Cdd:PRK15347 383 alaeakqraeqankrksehLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLAdtarqctlsLLAIInnlldfSRI--- 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 318 igyylhrasmRSGSALLSRELHPVAPLLDNLTSALNKVYQRKGVNISLDISPEISFVGEKnDFMEV---MGNLLDNACKy 394
Cdd:PRK15347 460 ----------ESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLHL-DSLRLrqiLVNLLGNAVK- 527
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 395 cleFVE-----VSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETSESLLG 469
Cdd:PRK15347 528 ---FTEtggirLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGV 604
|
....
gi 658547338 470 GARM 473
Cdd:PRK15347 605 GSCF 608
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
376-461 |
6.42e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 45.59 E-value: 6.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 376 EKNDFMEVMGNLLDNACKYCLE------FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQ-GVGLA 448
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASLRsdegnkIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGEhGIGLY 508
|
90
....*....|...
gi 658547338 449 VAREIVDQYDGKI 461
Cdd:PRK15053 509 LIASYVTRCGGVI 521
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
382-465 |
7.87e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 45.32 E-value: 7.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 382 EVMGNLLDNACKYCLE---FVEVSaRQTETELHIIVEDDGPGIPRNKRDVVFD--------RGQRADTlrpGQGVGLAVA 450
Cdd:PRK11091 401 QILWNLISNAVKFTQQggvTVRVR-YEEGDMLTFEVEDSGIGIPEDELDKIFAmyyqvkdsHGGKPAT---GTGIGLAVS 476
|
90
....*....|....*.
gi 658547338 451 REIVDQYDGKIE-TSE 465
Cdd:PRK11091 477 KRLAQAMGGDITvTSE 492
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
272-330 |
8.26e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 40.66 E-value: 8.26e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658547338 272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:pfam00512 6 LANLSHELRTPLTAIRGYLELLRDEKLDEEQREylETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
272-330 |
9.22e-05 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 40.63 E-value: 9.22e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 658547338 272 LTDLTHSLKTPLAVMQSTLRSMRSSKLSVDDAE--PVMLEQISRISQQIGYYLHRASMRSG 330
Cdd:smart00388 6 LANLSHELRTPLTAIRGYLELLLDTELSEEQREylETILREAERLLRLINDLLDLSRIEAG 66
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
271-471 |
9.64e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 45.06 E-value: 9.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 271 TLTDLTHSLKTPLAVMQSTLRSMRSS-KLSVDDAEPVMLEQISRISQQIGYYLhrASMRSGSALLSRELHPVaPLLDNLT 349
Cdd:COG4192 436 TMTSLAHELNQPLNAMSMYLFSAKKAlEQENYAQLPTSLDKIEGLIERMDKII--KSLRQFSRKSDTPLQPV-DLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 350 SALNKVYQR-KGVNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTET--ELHIIVEDDGPGIPRNKR 426
Cdd:COG4192 513 QAWELVESRaKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNaeNLRVAISDNGNGWPLVDK 592
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 658547338 427 dvvfdrgqradTLRP-------GQGVGLAVAREIVDQYDGKIETSESLLGGA 471
Cdd:COG4192 593 -----------LFTPftttkevGLGLGLSICRSIMQQFGGDLYLASTLERGA 633
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
387-458 |
1.06e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.82 E-value: 1.06e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547338 387 LLDNACKYCLEF-----VEVSARQTETELHIIVEDDGPGIPRNkrdvvfDRGQRADTLRPGqGVGLAVAREIVDQYD 458
Cdd:COG2172 42 AVTNAVRHAYGGdpdgpVEVELELDPDGLEIEVRDEGPGFDPE------DLPDPYSTLAEG-GRGLFLIRRLMDEVE 111
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
334-482 |
1.54e-04 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 44.28 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 334 LSRELHPVAPLLdnltsalnKVYQRKGVNISLDISPEISFV-GEKNDFMEVMGNLLDNACKYCLE--FVEVSARQTETEL 410
Cdd:PRK13837 522 LSELVTEIAPLL--------RVSLPPGVELDFDQDQEPAVVeGNPAELQQVLMNLCSNAAQAMDGagRVDISLSRAKLRA 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 411 H---------------IIVEDDGPGIPRNKRDVVFDRgqrADTLRP-GQGVGLAVAREIVDQYDGKIETSESLLGGARME 474
Cdd:PRK13837 594 PkvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEP---FFTTRAgGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFD 670
|
....*...
gi 658547338 475 VIFGRQQP 482
Cdd:PRK13837 671 VYLPPSSK 678
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
357-465 |
3.50e-04 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 42.85 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 357 QRKGVNISLDISPEISFVGEKNDFM-EVMGNLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDrg 433
Cdd:PRK10364 325 NSREIQLRFTANDTLPEIQADPDRLtQVLLNLYLNAIQAIGQhgVISVTASESGAGVKISVTDSGKGIAADQLEAIFT-- 402
|
90 100 110
....*....|....*....|....*....|...
gi 658547338 434 QRADTLRPGQGVGLAVAREIVDQYDGKIE-TSE 465
Cdd:PRK10364 403 PYFTTKAEGTGLGLAVVHNIVEQHGGTIQvASQ 435
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-477 |
3.66e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 40.14 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 386 NLLDNACKYCLE--FVEVSARQTETELHIIVEDDGPGIPRNKRDVVFDRGQRADTLRPGQ---GVGLAVAREIVDQYDGK 460
Cdd:cd16975 11 NIISNACQYAPEggTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGghyGMGLYIAKNLVEKHGGS 90
|
90
....*....|....*..
gi 658547338 461 IETSESLLGGArmEVIF 477
Cdd:cd16975 91 LIIENSQKGGA--EVTV 105
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
359-465 |
3.77e-03 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 39.83 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 359 KGVNISLDISPEI--SFVGEKNDFMEVMGNLLDNACKycleFVE----------VSARQTETELHIIVEDDGPGIPRNKR 426
Cdd:PRK11107 386 KGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIK----FTEsgnidilvelRALSNTKVQLEVQIRDTGIGISERQQ 461
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 658547338 427 DVVFDRGQRADT----LRPGQGVGLAVAREIVDQYDGKIE-TSE 465
Cdd:PRK11107 462 SQLFQAFRQADAsisrRHGGTGLGLVITQKLVNEMGGDISfHSQ 505
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
399-475 |
3.98e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 36.38 E-value: 3.98e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658547338 399 VEVSARQTETELHIIVEDDGPGiprnkrdvvFDRGQRAdtlrPGQGVGLAVAREIVDQYDGKIETSESLLGGARMEV 475
Cdd:cd16917 21 VRVTLSYTADELTLTVVDDGVG---------FDGPAPP----GGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTA 84
|
|
| NIP100 |
COG5244 |
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
221-378 |
5.19e-03 |
|
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 39.28 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 221 IESLAKEVREL-EEHHREKLNPE--TTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMqSTLRSMRSSK 297
Cdd:COG5244 88 ESKGMDKDGEIkQENHEDRIHFEesKIRRLEETIEALKSTEKEEIVELRRENEELDKINLSLRERISSE-EPELNKDGSK 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658547338 298 LSVDDAEPVMLE-------------QISRISQQIGYYLHRASMRSGSALLSRELHPVAPLLDNLTSALNKVYQRkgvnis 364
Cdd:COG5244 167 LSYDELKEFVEEsrvqvydmvelvsDISETLNRNGSIQRSSVRECERSNIHDVLFLVNGILDGVIDELNGELER------ 240
|
170
....*....|....
gi 658547338 365 ldISPEISFVGEKN 378
Cdd:COG5244 241 --LRRQLVSLMSSH 252
|
|
| |
