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LPS-assembly protein LptD [Verminephrobacter aporrectodeae]
Protein Classification
LPS-assembly protein LptD ( domain architecture ID 11444609 )
LPS-assembly protein LptD, together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
List of domain hits
Name
Accession
Description
Interval
E-value
LptD
COG1452 LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
25-754
0e+00
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain]
Cd Length: 702
Bit Score: 640.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 25 AQ EP AQ GADA PD AP P ALR A tprlqerippavrhrl P IFVTGEHIRGQI D LN T II - EG DAQL R H GD TVIR ADR MD Y TAPDD 103
Cdd:COG1452 1 AQ DA AQ ALSV PD LA P DDD A ---------------- P VLIEADSLEYDQ D DG T VT a EG NVEI R Q GD RRLK ADR VT Y DQKTG 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 104 LAR A H G R VR INRA G DRYE G T E L EL YV D AFQ GF FSD A Q Y W L LEPQAH G T A S R MDFLARD RT LVH NATYTTC ER GD apdwa P 183
Cdd:COG1452 65 TVT A E G N VR LTDG G NVLT G D E A EL NL D TKD GF IEN A R Y Q L VDRGGR G A A E R IKRTGDN RT RLE NATYTTC PP GD ----- P 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 184 DW VL RA ATLHI D STQET GTA ED A V LE F KGVP LLP L A Y I SFP LS DKRKSG L L P P TV G LD SR D G LTYTQ PYYWNIAPN R DAT 263
Cdd:COG1452 140 DW QI RA SRIIL D QEEKV GTA RN A R LE I KGVP VFY L P Y L SFP DP DKRKSG F L I P SF G SS SR L G FELSL PYYWNIAPN Y DAT 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 264 L RATL M Q KRG AS LGGE F RYL EPAYA G QI S -- G DLM P S D Q L RRH - S R WSFSGR H QGAFS sst DTLGLNLNL NRVSDDDY W R 340
Cdd:COG1452 220 L TPRY M S KRG LQ LGGE Y RYL FKSGS G EL S ir G EYL P D D R L GDN d D R GLLRWQ H SFDLN --- KGWRFGADV NRVSDDDY L R 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 341 DF GRAS G PLRQRL L PND A L L TW T RS D T - TTT LR TLKW QTL Q D vn APIVP PY D R M PQL QWR Y APLG L G G n LDA S VELDS T R 419
Cdd:COG1452 297 DF DSSL G SSSDDY L TSS A S L SR T YG D N w NLS LR AQHF QTL R D -- SDDDS PY Q R L PQL DFN Y VYRP L L G - GEF S LDAEA T N 373
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 420 F Q - AARERTGQ P NA TR SYAMAQI S R P FVQ P A G - YV TP RLQ L H AT Q YQ F D APLPGS T -- R S AQ R A LPTFSLDS A L M FERD T 495
Cdd:COG1452 374 F T r DDSDFQDG P DG TR LHLEPSW S L P LSR P G G l FL TP KAG L R AT A YQ L D NDSDPD T ld G S VS R V LPTFSLDS G L P FERD F 453
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 496 R f F G RAFL QTLEPR AF Y T Y T PYRDQS RL P VY DSA AN DF NL A TIYTE N AYG G N DR LA D N N L LTLG V T T RLLD PES G N E AI R 575
Cdd:COG1452 454 S - L G GGGT QTLEPR LQ Y L Y V PYRDQS DI P NF DSA LL DF DY A NLFSD N RFS G Y DR IE D G N Q LTLG L T S RLLD KDG G R E RL R 532
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 576 L GLA Q RLRLSE QR v TL PGNAP v NER LSDL LLG AS I R WTPRWD L DSML QY N P KQ GR SV R TTV G A RY S P GS y R T L SAA YR RQ 655
Cdd:COG1452 533 L SVG Q SYYFAD QR - TL ADDSG - STK LSDL VAE AS L R PNDGLS L TARA QY D P YT GR VN R GNA G L RY R P DR - R N L NLG YR YL 609
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 656 R G -------- TS EQ I D IGWQ WPL N D L W G dkgqdlgpgggqggrrwy G VGR LN Y S L Q D S RL IN T IV GLEYD G CCW IGSV V L 727
Cdd:COG1452 610 R D dpdygysd DI EQ L D LSGS WPL T D N W S ------------------ V VGR YR Y D L T D N RL VE T LL GLEYD D CCW ALRL V Y 671
730 740
....*....|....*....|....*....
gi 657839529 728 E R LQNGT S TS -- N T RLLL Q I E FL GL SR L S 754
Cdd:COG1452 672 R R YYTSG S DL ey D T SFFF Q L E LK GL GS L G 700
Name
Accession
Description
Interval
E-value
LptD
COG1452 LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
25-754
0e+00
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain]
Cd Length: 702
Bit Score: 640.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 25 AQ EP AQ GADA PD AP P ALR A tprlqerippavrhrl P IFVTGEHIRGQI D LN T II - EG DAQL R H GD TVIR ADR MD Y TAPDD 103
Cdd:COG1452 1 AQ DA AQ ALSV PD LA P DDD A ---------------- P VLIEADSLEYDQ D DG T VT a EG NVEI R Q GD RRLK ADR VT Y DQKTG 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 104 LAR A H G R VR INRA G DRYE G T E L EL YV D AFQ GF FSD A Q Y W L LEPQAH G T A S R MDFLARD RT LVH NATYTTC ER GD apdwa P 183
Cdd:COG1452 65 TVT A E G N VR LTDG G NVLT G D E A EL NL D TKD GF IEN A R Y Q L VDRGGR G A A E R IKRTGDN RT RLE NATYTTC PP GD ----- P 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 184 DW VL RA ATLHI D STQET GTA ED A V LE F KGVP LLP L A Y I SFP LS DKRKSG L L P P TV G LD SR D G LTYTQ PYYWNIAPN R DAT 263
Cdd:COG1452 140 DW QI RA SRIIL D QEEKV GTA RN A R LE I KGVP VFY L P Y L SFP DP DKRKSG F L I P SF G SS SR L G FELSL PYYWNIAPN Y DAT 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 264 L RATL M Q KRG AS LGGE F RYL EPAYA G QI S -- G DLM P S D Q L RRH - S R WSFSGR H QGAFS sst DTLGLNLNL NRVSDDDY W R 340
Cdd:COG1452 220 L TPRY M S KRG LQ LGGE Y RYL FKSGS G EL S ir G EYL P D D R L GDN d D R GLLRWQ H SFDLN --- KGWRFGADV NRVSDDDY L R 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 341 DF GRAS G PLRQRL L PND A L L TW T RS D T - TTT LR TLKW QTL Q D vn APIVP PY D R M PQL QWR Y APLG L G G n LDA S VELDS T R 419
Cdd:COG1452 297 DF DSSL G SSSDDY L TSS A S L SR T YG D N w NLS LR AQHF QTL R D -- SDDDS PY Q R L PQL DFN Y VYRP L L G - GEF S LDAEA T N 373
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 420 F Q - AARERTGQ P NA TR SYAMAQI S R P FVQ P A G - YV TP RLQ L H AT Q YQ F D APLPGS T -- R S AQ R A LPTFSLDS A L M FERD T 495
Cdd:COG1452 374 F T r DDSDFQDG P DG TR LHLEPSW S L P LSR P G G l FL TP KAG L R AT A YQ L D NDSDPD T ld G S VS R V LPTFSLDS G L P FERD F 453
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 496 R f F G RAFL QTLEPR AF Y T Y T PYRDQS RL P VY DSA AN DF NL A TIYTE N AYG G N DR LA D N N L LTLG V T T RLLD PES G N E AI R 575
Cdd:COG1452 454 S - L G GGGT QTLEPR LQ Y L Y V PYRDQS DI P NF DSA LL DF DY A NLFSD N RFS G Y DR IE D G N Q LTLG L T S RLLD KDG G R E RL R 532
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 576 L GLA Q RLRLSE QR v TL PGNAP v NER LSDL LLG AS I R WTPRWD L DSML QY N P KQ GR SV R TTV G A RY S P GS y R T L SAA YR RQ 655
Cdd:COG1452 533 L SVG Q SYYFAD QR - TL ADDSG - STK LSDL VAE AS L R PNDGLS L TARA QY D P YT GR VN R GNA G L RY R P DR - R N L NLG YR YL 609
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 656 R G -------- TS EQ I D IGWQ WPL N D L W G dkgqdlgpgggqggrrwy G VGR LN Y S L Q D S RL IN T IV GLEYD G CCW IGSV V L 727
Cdd:COG1452 610 R D dpdygysd DI EQ L D LSGS WPL T D N W S ------------------ V VGR YR Y D L T D N RL VE T LL GLEYD D CCW ALRL V Y 671
730 740
....*....|....*....|....*....
gi 657839529 728 E R LQNGT S TS -- N T RLLL Q I E FL GL SR L S 754
Cdd:COG1452 672 R R YYTSG S DL ey D T SFFF Q L E LK GL GS L G 700
PRK04423
PRK04423 LPS-assembly protein LptD;
13-781
2.00e-102
LPS-assembly protein LptD;
Pssm-ID: 235297 [Multi-domain]
Cd Length: 798
Bit Score: 333.76
E-value: 2.00e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 13 AL A C C a LP HA A LAQEPAQ G - AD A P D AP P ALRAT P RLQERIP p AV R HR LP IFVT G EHIR G QIDL n TIIE G DAQ L RH GD TVI 91
Cdd:PRK04423 13 SI A I C - LP AM A AEKPLNW G l CP A V D PL P GFDGA P AADPKAA - EM R QQ LP TDIE G DQLS G TSTT - PQYQ G NVA L KR GD QFL 89
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 92 R AD -- RMD YTAPDDL A RAHG R VR --- I NRAG DR Y EG TE lelyv D AFQGFFSDA QY W L LEPQAH G T A SRM D f L ARDRTLV H 166
Cdd:PRK04423 90 G AD nl RMD TETGNYI A EGNV R YQ dts I RMVA DR A EG NQ ----- D TDTHKITNI QY Q L VSRRGN G D A ESV D - L QGQVGQM H 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 167 NA TYTTC ERGD apdwa P D W V LRA ATLHI D STQET GTA ED AVL EFKG VP L L PLAYIS FP LS D K R KS GLL P P TV GL DS R D G L 246
Cdd:PRK04423 164 RS TYTTC DPSQ ----- P I W R LRA PEIDV D NDEGF GTA RN AVL QIGK VP V L YFPWFK FP ID D R R QT GLL F P QF GL SG R N G F 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 247 T Y T QP Y Y W N I APN R DATL RATL M Q KRG ASL G G EFRYL EPAYA G QIS G DLM P S D Q LR RHS R -- WSF SG R H qgafs SSTDTL 324
Cdd:PRK04423 239 D Y L QP I Y L N L APN Y DATL LPRY M S KRG FMF G T EFRYL YDGGR G EVT G NYL P N D K LR DKD R gr VFY SG Y H ----- NVNSHW 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 325 GLNLN L NR VSD DD Y WR DF - G R AS G PLRQRL L PNDALLTW T RSDT T TT L RTLK WQ TLQDVNAPIVP PY D R M P QLQWRYAP l 403
Cdd:PRK04423 314 QARAS L SW VSD TR Y VE DF t S R LN G MGSASS L QSTVGIYG T GETW T AG L MADR WQ LTDYTLDERAL PY N R Q P RAYFNWEK - 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 404 GLG G NLD A S V ELDST RF Q --------------- AARE RTG QP N ----- AT R SYAMAQI S R P FVQP A GY VTP R L QLHA T Q Y 463
Cdd:PRK04423 393 PVF G IFE A G V YAEAV RF T hddsylvqppndgdd DNYV RTG IV N reygs GS R LDVKPYV S M P LSGA A WF VTP T L AWRY T A Y 472
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 464 Q F D ------ APL P G S t RS AQ R A LP TF SLD SA L M F E R D T RF FG RAF L Q TLEPR AF Y T Y T PYR D Q SR LPV Y D SAAND F NLAT 537
Cdd:PRK04423 473 Q L D stlaet APL T G D - RS PS R S LP IA SLD AG L Y F D R E T SL FG TNY L N TLEPR LY Y L Y V PYR N Q DD LPV F D TRPFT F SWGQ 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 538 IYTENA Y G G N DR LA D N N L LTL G VT T R L L DPES G N E AIR L GLA Q R L RLSEQR VT L - PGNAPVNERL S DLLLG A SIRWTP RW 616
Cdd:PRK04423 552 LFRDSR Y T G A DR QN D A N Q LTL A VT S R W L RQDD G K E KLS L SAG Q I L YFDDSL VT I n NSEQTIEQGK S AWVAD A NYMIND RW 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 617 D L DSML Q Y NP KQG R SVRTTVGA RY SPGSYRTLSA AYR RQ R GTS ------ E Q I D IGWQW P L N DL W gdkgqdlgpgggqggr 690
Cdd:PRK04423 632 T L GATY Q W NP NSR R EDLASLRT RY LLPNDGIINL AYR YR R NLI dnsdql K Q A D FSFLY P I N PR W ---------------- 695
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 691 rw YG VGR LN YSL Q D SRLINT I V G LEY D G CC WIGSVVLE R - LQ N GTSTSNTRLLLQIEFL GLS rl S L G ANPQE T FKHNVPR 769
Cdd:PRK04423 696 -- SA VGR YY YSL L D KKPLEI I G G VQW D S CC LAVRALVR R f VR N RDGEMDNSIQIEFVLK GLS -- S F G QDTDR T LRRAILG 771
810
....*....|..
gi 657839529 770 Y QYLREQVA PPS 781
Cdd:PRK04423 772 Y YRDDLYLV PPS 783
LptD
pfam04453 LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria ...
304-674
7.46e-88
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. This family includes members such as LPTD found in Shigella flexneri and Yersinia pestis. Structural analysis indicates that LptD forms a novel 26-stranded beta-barrel. It interacts with LPTE where LptE adopts a roll-like structure located inside the barrel of LptD. The LPS translocon LptD is unable to fold properly in the absence of LptE and the two proteins form a unique barrel and plug architecture for LPS transport and insertion. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. It has been suggested that LptD is a promising target for the development of effective vaccines and antibody-based therapies to control Vibrio infection.
Pssm-ID: 427958
Cd Length: 384
Bit Score: 282.76
E-value: 7.46e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 304 HS R WS F SGR HQ GAFS sst D TLGLNLNL N R VSD DD Y W RD FGRAS G PLR Q RL L PNDAL L TWTRSDTTTT LR TLKW QTL QDVN 383
Cdd:pfam04453 1 KN R GY F NAS HQ FILN --- D NWSFGVDY N Y VSD KN Y F RD YDSNI G LVS Q TY L LRQGR L SYRNDNWDFS LR VQDY QTL DPTI 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 384 APIVP PY D R M PQL QWR Y - A P LGLG G N LD A S VELDST RF Q aa R ERTG QP NA TR SYAMAQ IS R PF VQ P A G YV TP R L Q L HA T Q 462
Cdd:pfam04453 78 ISNDT PY Q R L PQL DYN Y y K P DPGF G G LD F S FDSQYV RF S -- R DDGQ QP TG TR LHLEPE IS L PF TN P W G FL TP E L K L RG T A 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 463 Y QF D AP L PGSTR ------- S AQ R A LPTFSLDS A L M FERDT RF FG r AFL QTLEPRA F Y T Y T PYRDQ SR LP V YDS AAN DF NL 535
Cdd:pfam04453 156 Y DL D VD L GPGEN atgglds S VT R V LPTFSLDS G L P FERDT TL FG - DYT QTLEPRA Q Y L Y V PYRDQ NN LP N YDS SSL DF DY 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 536 ATIYTE N AYG G N DR LA D N N L LT L GVT T R LL D PES G N E AI RL GLA Q RLRLSEQ RV T L - PGNAPVNE R L SDL LLGA S IRWTP 614
Cdd:pfam04453 235 TNLFRD N RFS G Y DR IE D A N Q LT Y GVT S R FF D ANG G F E RL RL SVG Q SFYFTDR RV F L i GDESGLTR R S SDL VAEL S FSPNR 314
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 615 RWD L DSML QY N P KQGRSV R TT VG AR Y S P ------- GS YR TLSAAYRR Q RG T S --- E QI DIGW QWPL N D L W 674
Cdd:pfam04453 315 GLN L SASI QY D P YTNNFE R GE VG LS Y R P drgnsin LG YR YRRNDPEY Q NA T N ngi S QI GLSA QWPL A D N W 384
Name
Accession
Description
Interval
E-value
LptD
COG1452 LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
25-754
0e+00
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441061 [Multi-domain]
Cd Length: 702
Bit Score: 640.50
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 25 AQ EP AQ GADA PD AP P ALR A tprlqerippavrhrl P IFVTGEHIRGQI D LN T II - EG DAQL R H GD TVIR ADR MD Y TAPDD 103
Cdd:COG1452 1 AQ DA AQ ALSV PD LA P DDD A ---------------- P VLIEADSLEYDQ D DG T VT a EG NVEI R Q GD RRLK ADR VT Y DQKTG 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 104 LAR A H G R VR INRA G DRYE G T E L EL YV D AFQ GF FSD A Q Y W L LEPQAH G T A S R MDFLARD RT LVH NATYTTC ER GD apdwa P 183
Cdd:COG1452 65 TVT A E G N VR LTDG G NVLT G D E A EL NL D TKD GF IEN A R Y Q L VDRGGR G A A E R IKRTGDN RT RLE NATYTTC PP GD ----- P 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 184 DW VL RA ATLHI D STQET GTA ED A V LE F KGVP LLP L A Y I SFP LS DKRKSG L L P P TV G LD SR D G LTYTQ PYYWNIAPN R DAT 263
Cdd:COG1452 140 DW QI RA SRIIL D QEEKV GTA RN A R LE I KGVP VFY L P Y L SFP DP DKRKSG F L I P SF G SS SR L G FELSL PYYWNIAPN Y DAT 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 264 L RATL M Q KRG AS LGGE F RYL EPAYA G QI S -- G DLM P S D Q L RRH - S R WSFSGR H QGAFS sst DTLGLNLNL NRVSDDDY W R 340
Cdd:COG1452 220 L TPRY M S KRG LQ LGGE Y RYL FKSGS G EL S ir G EYL P D D R L GDN d D R GLLRWQ H SFDLN --- KGWRFGADV NRVSDDDY L R 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 341 DF GRAS G PLRQRL L PND A L L TW T RS D T - TTT LR TLKW QTL Q D vn APIVP PY D R M PQL QWR Y APLG L G G n LDA S VELDS T R 419
Cdd:COG1452 297 DF DSSL G SSSDDY L TSS A S L SR T YG D N w NLS LR AQHF QTL R D -- SDDDS PY Q R L PQL DFN Y VYRP L L G - GEF S LDAEA T N 373
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 420 F Q - AARERTGQ P NA TR SYAMAQI S R P FVQ P A G - YV TP RLQ L H AT Q YQ F D APLPGS T -- R S AQ R A LPTFSLDS A L M FERD T 495
Cdd:COG1452 374 F T r DDSDFQDG P DG TR LHLEPSW S L P LSR P G G l FL TP KAG L R AT A YQ L D NDSDPD T ld G S VS R V LPTFSLDS G L P FERD F 453
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 496 R f F G RAFL QTLEPR AF Y T Y T PYRDQS RL P VY DSA AN DF NL A TIYTE N AYG G N DR LA D N N L LTLG V T T RLLD PES G N E AI R 575
Cdd:COG1452 454 S - L G GGGT QTLEPR LQ Y L Y V PYRDQS DI P NF DSA LL DF DY A NLFSD N RFS G Y DR IE D G N Q LTLG L T S RLLD KDG G R E RL R 532
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 576 L GLA Q RLRLSE QR v TL PGNAP v NER LSDL LLG AS I R WTPRWD L DSML QY N P KQ GR SV R TTV G A RY S P GS y R T L SAA YR RQ 655
Cdd:COG1452 533 L SVG Q SYYFAD QR - TL ADDSG - STK LSDL VAE AS L R PNDGLS L TARA QY D P YT GR VN R GNA G L RY R P DR - R N L NLG YR YL 609
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 656 R G -------- TS EQ I D IGWQ WPL N D L W G dkgqdlgpgggqggrrwy G VGR LN Y S L Q D S RL IN T IV GLEYD G CCW IGSV V L 727
Cdd:COG1452 610 R D dpdygysd DI EQ L D LSGS WPL T D N W S ------------------ V VGR YR Y D L T D N RL VE T LL GLEYD D CCW ALRL V Y 671
730 740
....*....|....*....|....*....
gi 657839529 728 E R LQNGT S TS -- N T RLLL Q I E FL GL SR L S 754
Cdd:COG1452 672 R R YYTSG S DL ey D T SFFF Q L E LK GL GS L G 700
PRK04423
PRK04423 LPS-assembly protein LptD;
13-781
2.00e-102
LPS-assembly protein LptD;
Pssm-ID: 235297 [Multi-domain]
Cd Length: 798
Bit Score: 333.76
E-value: 2.00e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 13 AL A C C a LP HA A LAQEPAQ G - AD A P D AP P ALRAT P RLQERIP p AV R HR LP IFVT G EHIR G QIDL n TIIE G DAQ L RH GD TVI 91
Cdd:PRK04423 13 SI A I C - LP AM A AEKPLNW G l CP A V D PL P GFDGA P AADPKAA - EM R QQ LP TDIE G DQLS G TSTT - PQYQ G NVA L KR GD QFL 89
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 92 R AD -- RMD YTAPDDL A RAHG R VR --- I NRAG DR Y EG TE lelyv D AFQGFFSDA QY W L LEPQAH G T A SRM D f L ARDRTLV H 166
Cdd:PRK04423 90 G AD nl RMD TETGNYI A EGNV R YQ dts I RMVA DR A EG NQ ----- D TDTHKITNI QY Q L VSRRGN G D A ESV D - L QGQVGQM H 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 167 NA TYTTC ERGD apdwa P D W V LRA ATLHI D STQET GTA ED AVL EFKG VP L L PLAYIS FP LS D K R KS GLL P P TV GL DS R D G L 246
Cdd:PRK04423 164 RS TYTTC DPSQ ----- P I W R LRA PEIDV D NDEGF GTA RN AVL QIGK VP V L YFPWFK FP ID D R R QT GLL F P QF GL SG R N G F 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 247 T Y T QP Y Y W N I APN R DATL RATL M Q KRG ASL G G EFRYL EPAYA G QIS G DLM P S D Q LR RHS R -- WSF SG R H qgafs SSTDTL 324
Cdd:PRK04423 239 D Y L QP I Y L N L APN Y DATL LPRY M S KRG FMF G T EFRYL YDGGR G EVT G NYL P N D K LR DKD R gr VFY SG Y H ----- NVNSHW 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 325 GLNLN L NR VSD DD Y WR DF - G R AS G PLRQRL L PNDALLTW T RSDT T TT L RTLK WQ TLQDVNAPIVP PY D R M P QLQWRYAP l 403
Cdd:PRK04423 314 QARAS L SW VSD TR Y VE DF t S R LN G MGSASS L QSTVGIYG T GETW T AG L MADR WQ LTDYTLDERAL PY N R Q P RAYFNWEK - 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 404 GLG G NLD A S V ELDST RF Q --------------- AARE RTG QP N ----- AT R SYAMAQI S R P FVQP A GY VTP R L QLHA T Q Y 463
Cdd:PRK04423 393 PVF G IFE A G V YAEAV RF T hddsylvqppndgdd DNYV RTG IV N reygs GS R LDVKPYV S M P LSGA A WF VTP T L AWRY T A Y 472
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 464 Q F D ------ APL P G S t RS AQ R A LP TF SLD SA L M F E R D T RF FG RAF L Q TLEPR AF Y T Y T PYR D Q SR LPV Y D SAAND F NLAT 537
Cdd:PRK04423 473 Q L D stlaet APL T G D - RS PS R S LP IA SLD AG L Y F D R E T SL FG TNY L N TLEPR LY Y L Y V PYR N Q DD LPV F D TRPFT F SWGQ 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 538 IYTENA Y G G N DR LA D N N L LTL G VT T R L L DPES G N E AIR L GLA Q R L RLSEQR VT L - PGNAPVNERL S DLLLG A SIRWTP RW 616
Cdd:PRK04423 552 LFRDSR Y T G A DR QN D A N Q LTL A VT S R W L RQDD G K E KLS L SAG Q I L YFDDSL VT I n NSEQTIEQGK S AWVAD A NYMIND RW 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 617 D L DSML Q Y NP KQG R SVRTTVGA RY SPGSYRTLSA AYR RQ R GTS ------ E Q I D IGWQW P L N DL W gdkgqdlgpgggqggr 690
Cdd:PRK04423 632 T L GATY Q W NP NSR R EDLASLRT RY LLPNDGIINL AYR YR R NLI dnsdql K Q A D FSFLY P I N PR W ---------------- 695
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 691 rw YG VGR LN YSL Q D SRLINT I V G LEY D G CC WIGSVVLE R - LQ N GTSTSNTRLLLQIEFL GLS rl S L G ANPQE T FKHNVPR 769
Cdd:PRK04423 696 -- SA VGR YY YSL L D KKPLEI I G G VQW D S CC LAVRALVR R f VR N RDGEMDNSIQIEFVLK GLS -- S F G QDTDR T LRRAILG 771
810
....*....|..
gi 657839529 770 Y QYLREQVA PPS 781
Cdd:PRK04423 772 Y YRDDLYLV PPS 783
LptD
pfam04453 LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria ...
304-674
7.46e-88
LPS transport system D; Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic compounds, including antibiotics. This family includes members such as LPTD found in Shigella flexneri and Yersinia pestis. Structural analysis indicates that LptD forms a novel 26-stranded beta-barrel. It interacts with LPTE where LptE adopts a roll-like structure located inside the barrel of LptD. The LPS translocon LptD is unable to fold properly in the absence of LptE and the two proteins form a unique barrel and plug architecture for LPS transport and insertion. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet. It has been suggested that LptD is a promising target for the development of effective vaccines and antibody-based therapies to control Vibrio infection.
Pssm-ID: 427958
Cd Length: 384
Bit Score: 282.76
E-value: 7.46e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 304 HS R WS F SGR HQ GAFS sst D TLGLNLNL N R VSD DD Y W RD FGRAS G PLR Q RL L PNDAL L TWTRSDTTTT LR TLKW QTL QDVN 383
Cdd:pfam04453 1 KN R GY F NAS HQ FILN --- D NWSFGVDY N Y VSD KN Y F RD YDSNI G LVS Q TY L LRQGR L SYRNDNWDFS LR VQDY QTL DPTI 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 384 APIVP PY D R M PQL QWR Y - A P LGLG G N LD A S VELDST RF Q aa R ERTG QP NA TR SYAMAQ IS R PF VQ P A G YV TP R L Q L HA T Q 462
Cdd:pfam04453 78 ISNDT PY Q R L PQL DYN Y y K P DPGF G G LD F S FDSQYV RF S -- R DDGQ QP TG TR LHLEPE IS L PF TN P W G FL TP E L K L RG T A 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 463 Y QF D AP L PGSTR ------- S AQ R A LPTFSLDS A L M FERDT RF FG r AFL QTLEPRA F Y T Y T PYRDQ SR LP V YDS AAN DF NL 535
Cdd:pfam04453 156 Y DL D VD L GPGEN atgglds S VT R V LPTFSLDS G L P FERDT TL FG - DYT QTLEPRA Q Y L Y V PYRDQ NN LP N YDS SSL DF DY 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 536 ATIYTE N AYG G N DR LA D N N L LT L GVT T R LL D PES G N E AI RL GLA Q RLRLSEQ RV T L - PGNAPVNE R L SDL LLGA S IRWTP 614
Cdd:pfam04453 235 TNLFRD N RFS G Y DR IE D A N Q LT Y GVT S R FF D ANG G F E RL RL SVG Q SFYFTDR RV F L i GDESGLTR R S SDL VAEL S FSPNR 314
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 615 RWD L DSML QY N P KQGRSV R TT VG AR Y S P ------- GS YR TLSAAYRR Q RG T S --- E QI DIGW QWPL N D L W 674
Cdd:pfam04453 315 GLN L SASI QY D P YTNNFE R GE VG LS Y R P drgnsin LG YR YRRNDPEY Q NA T N ngi S QI GLSA QWPL A D N W 384
PRK03761
PRK03761 LPS assembly outer membrane complex protein LptD; Provisional
59-771
4.00e-80
LPS assembly outer membrane complex protein LptD; Provisional
Pssm-ID: 235158 [Multi-domain]
Cd Length: 778
Bit Score: 273.34
E-value: 4.00e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 59 LP IFVTGE H IRGQIDLNTIIE G DAQLRH G DTVIR AD RMDYT -------- A P DDLAR A H G R V R ----- I NRA G DR ------ 119
Cdd:PRK03761 49 LP VTIEAD H AEANYPDDAVYT G NVDIKQ G NSRLT AD EVQLH qqenpgqa E P VRTVD A L G N V H yddnq I ILK G PK awsnln 128
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 120 YEG T ELE lyvdafqgffs DAQ Y WLLEP Q AH G T A SR M DFLARD R - T LVH N ATY T T C ER GD A pdwap D W VLRAATLHI D STQ 198
Cdd:PRK03761 129 TKD T NVW ----------- NGD Y QMVGR Q GR G K A DL M KQRGQN R y T ILE N GSF T S C LP GD N ----- S W SVVGSEIIH D REE 192
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 199 E TGTAED A VLEFK GVP LLPLA Y ISF P LS DKR K SG L L P P TVGLD S RD G LTYTQ PYYWNIAPN R DAT LRATL M QK RG ASLGG 278
Cdd:PRK03761 193 E VAEIWN A RFKVG GVP VFYSP Y LQL P IG DKR R SG F L I P NAKYS S KN G FEFEL PYYWNIAPN Y DAT ITPHY M SR RG WQWEN 272
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 279 EFRYL EP A Y AG QIS G DLM PSD QL ------- RRH SRW S F SGR H Q G AFSSS tdt LGL N LNLNR VSD DD Y WR DF ----- GRAS 346
Cdd:PRK03761 273 EFRYL TQ A G AG LMA G EYL PSD RV yedepnd DNS SRW L F YWN H S G VMDQV --- WRF N VDYTK VSD PR Y FT DF dskyg SSTD 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 347 G PLR Q R llpnd ALLTWTRSDTTT TL R T LKW Q TLQDV N api VP PY DRM PQL QWR Y APLG LG gnldasv EL D STRF - QA A R - 424
Cdd:PRK03761 350 G YAT Q K ----- FSVGYAQQNWNA TL S T KQF Q VFDEQ N --- NS PY RAE PQL DFN Y YQND LG ------- PF D FRLY g QA V R f 414
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 425 -- ERTGQ P N ATR SYAMAQISR P FVQPA G YVTPRLQ L H AT Q YQ F D AP ------- LPGSTR S AQ R AL P T F SL D SALM FERD T 495
Cdd:PRK03761 415 tn DNKNM P E ATR VHLEPTLNL P LSNRW G SLNTEAK L L AT H YQ Q D NL dwynsnn TTKLEE S VN R VI P Q F KV D GKMV FERD M 494
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 496 RFFG r AFL QTLEPR AF Y T Y T PYRDQS RLPV YDS AA ndfn L ATI Y T ---- ENA Y G G N DR L A DN N LL T L GVTTR LL D p ESGN 571
Cdd:PRK03761 495 DLAP - GYT QTLEPR VQ Y L Y V PYRDQS NIYN YDS TL ---- L QSD Y Y glfr DRT Y S G L DR I A SA N QV T T GVTTR FY D - DAAV 568
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 572 E AIRLGLA Q RLRLSEQ R V - TLPGNAPVNERL S DLLL G AS - I R WTP RW ---------- D LDS M ------ L Q Y NPKQG R SVR 633
Cdd:PRK03761 569 E RFNISVG Q IYYFTPS R T g DNNTWENDDKTG S SVWA G DT y W R ISD RW glrggiqydt R LDS V alanss L E Y RRDED R LIQ 648
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 634 ttvgarysp GS YR TL S AA Y RRQRGT S EQIDIGW Q ----------- WP LN D L W G dkgqdlgpgggqggrrwy G VG RLN Y SL 702
Cdd:PRK03761 649 --------- LN YR YA S PE Y IQATLP S YYSAEIY Q qgisqvgavas WP IA D R W S ------------------ I VG AYY Y DT 701
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 657839529 703 QDSRLINTIV GL E Y DG CCW IGS V VL ER LQN G TSTSN ------ TRLLLQ IE FL GLS R l SL G ANP QE TFKH N VPR YQ 771
Cdd:PRK03761 702 KANKPAEQLL GL Q Y NS CCW AIG V GY ER KLT G WDNDK qhsvyd NKIGFN IE LR GLS S - NY G LGT QE MLRS N ILP YQ 775
LptD_2
pfam19838 LptD protein; This entry likely represents the LptD homolog of Bacteriodetes bacteria. LptD is ...
206-282
2.02e-06
LptD protein; This entry likely represents the LptD homolog of Bacteriodetes bacteria. LptD is an essential outer membrane protein that mediates the final transport of lipopolysaccharide (LPS) to outer leaflet.
Pssm-ID: 466203
Cd Length: 474
Bit Score: 51.02
E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 206 A V L EFKG VP L --- LP LAY is FPL - S DK R K SG LLP PT V G LDSRD G L t YTQP -- YY WN I APNR D A TL RATLMQ K RGAS L GG E 279
Cdd:pfam19838 6 A N L YIED VP T plg LP FGF -- FPL t S GR R R SG III PT Y G ESNDR G F - FLRN gg YY FA I NDYF D L TL TGDIYT K GSWG L NA E 82
...
gi 657839529 280 F RY 282
Cdd:pfam19838 83 S RY 85
LptA
COG1934 Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
12-204
5.44e-04
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441537 [Multi-domain]
Cd Length: 164
Bit Score: 41.44
E-value: 5.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 12 A AL ACCA L PHA ALAQ EPAQGA dapdappalratprlqerippavrhrl PI FVTGEHIRGQIDLN T II - E G DAQLRH G DTV 90
Cdd:COG1934 4 L AL LLLL L AAP ALAQ KADRDQ --------------------------- PI EIEADRLEVDDKKG T AV f T G NVVVTQ G TLT 56
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657839529 91 I RAD RMD -- Y TAPDDLA R -- A H G R V RINRAG D RYEGT E lelyvdafqgffsdaqywllepqah G TA S R MDFLARDR T L V - 165
Cdd:COG1934 57 L RAD KLV vy Y DKAGGIE R ie A T G N V TFRQKR D GGQEV E ------------------------- A TA D R AEYDVATD T V V l 111
170 180 190 200
....*....|....*....|....*....|....*....|
gi 657839529 166 - H NA TY T tce R G DA pdwapdw VLRAATLHI D STQETG TAE 204
Cdd:COG1934 112 t G NA VL T --- Q G GN ------- TVTGDRITY D LKTGRA TAE 141
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
