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Conserved domains on  [gi|657198595|ref|WP_029314225|]
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MULTISPECIES: ArsC family reductase [Aeromonas]

Protein Classification

arsenate reductase( domain architecture ID 10122554)

glutathione dependent arsenate reductase family, Yffb subfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 9-115 1.11e-57

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


:

Pssm-ID: 239333  Cd Length: 105  Bit Score: 173.55  E-value: 1.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEALLNTRGTTFRALPEAEKQGLDTAKAR 88
Cdd:cd03035    1 ITLYGI--KNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGWETLLNKRGTTWRKLDDAQKAALDAAKAI 78

                         90       100
                 ....*....|....*....|....*..
gi 657198595  89 DLLLAHPAMIKRPLLDQDGTLTLGFKA 115
Cdd:cd03035   79 ALMLEHPSLIKRPVLETGGKVLVGFSE 105
 
Name Accession Description Interval E-value
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 9-115 1.11e-57

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239333  Cd Length: 105  Bit Score: 173.55  E-value: 1.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEALLNTRGTTFRALPEAEKQGLDTAKAR 88
Cdd:cd03035    1 ITLYGI--KNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGWETLLNKRGTTWRKLDDAQKAALDAAKAI 78

                         90       100
                 ....*....|....*....|....*..
gi 657198595  89 DLLLAHPAMIKRPLLDQDGTLTLGFKA 115
Cdd:cd03035   79 ALMLEHPSLIKRPVLETGGKVLVGFSE 105
PRK10853 PRK10853
putative reductase; Provisional
 9-123 3.12e-57

putative reductase; Provisional


Pssm-ID: 182780  Cd Length: 118  Bit Score: 172.93  E-value: 3.12e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEALLNTRGTTFRALPEAEKQGLDTAK-A 87
Cdd:PRK10853   2 VTLYGI--KNCDTIKKARRWLEAQGIDYRFHDYRVDGLDSELLQGFIDELGWEALLNTRGTTWRKLDETQRNAITDAAsA 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 657198595  88 RDLLLAHPAMIKRPLL-DQDGTLTLGFKADLYQSLFS 123
Cdd:PRK10853  80 AALMLEQPAIIKRPLLcAPGKPMLLGFSESSYQQFFH 116
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 8-122 1.26e-44

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 141.00  E-value: 1.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   8 KVVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLG--WEALLNTRGTTFRALPEAEKQgLDTA 85
Cdd:COG1393    1 MITIYGN--PNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAKLGlgVEELLNTRGTTYRELGLKDKA-LSEE 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 657198595  86 KARDLLLAHPAMIKRPLLDQDGTLTLGFKADLYQSLF 122
Cdd:COG1393   78 EALALMLEHPSLIKRPIVVTGDKALVGFPPEEVLALL 114
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 12-119 2.32e-35

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 117.32  E-value: 2.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   12 YGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKL--GWEALLNTRGTTFRALPEAEKQgLDTAKARD 89
Cdd:pfam03960   1 YGS--PNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLgdGVEALLNTRGTTYRELNLDKED-LSEDELLE 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 657198595   90 LLLAHPAMIKRPLLDQDGTLTLGFKADLYQ 119
Cdd:pfam03960  78 LILEHPSLIRRPIVVDGGKLLVGFNEEEIR 107
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 11-119 9.42e-33

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 110.98  E-value: 9.42e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   11 LYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKL--GWEALLNTRGTTFRAL-PEAEKQGLDTAKA 87
Cdd:TIGR01617   3 VYGS--PNCTTCKKARRWLEANGIEYQFIDIGEDGPTREELLDILSLLedGIDPLLNTRGQSYRALnTSNTFLDLSDKEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 657198595   88 RDLLLAHPAMIKRPLL-DQDGTLTLGFKADLYQ 119
Cdd:TIGR01617  81 LELLAEDPALLRRPLIvDTKNRLLIGFKSESIE 113
 
Name Accession Description Interval E-value
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 9-115 1.11e-57

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239333  Cd Length: 105  Bit Score: 173.55  E-value: 1.11e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEALLNTRGTTFRALPEAEKQGLDTAKAR 88
Cdd:cd03035    1 ITLYGI--KNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGWETLLNKRGTTWRKLDDAQKAALDAAKAI 78

                         90       100
                 ....*....|....*....|....*..
gi 657198595  89 DLLLAHPAMIKRPLLDQDGTLTLGFKA 115
Cdd:cd03035   79 ALMLEHPSLIKRPVLETGGKVLVGFSE 105
PRK10853 PRK10853
putative reductase; Provisional
 9-123 3.12e-57

putative reductase; Provisional


Pssm-ID: 182780  Cd Length: 118  Bit Score: 172.93  E-value: 3.12e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEALLNTRGTTFRALPEAEKQGLDTAK-A 87
Cdd:PRK10853   2 VTLYGI--KNCDTIKKARRWLEAQGIDYRFHDYRVDGLDSELLQGFIDELGWEALLNTRGTTWRKLDETQRNAITDAAsA 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 657198595  88 RDLLLAHPAMIKRPLL-DQDGTLTLGFKADLYQSLFS 123
Cdd:PRK10853  80 AALMLEQPAIIKRPLLcAPGKPMLLGFSESSYQQFFH 116
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 8-122 1.26e-44

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 141.00  E-value: 1.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   8 KVVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLG--WEALLNTRGTTFRALPEAEKQgLDTA 85
Cdd:COG1393    1 MITIYGN--PNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAKLGlgVEELLNTRGTTYRELGLKDKA-LSEE 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 657198595  86 KARDLLLAHPAMIKRPLLDQDGTLTLGFKADLYQSLF 122
Cdd:COG1393   78 EALALMLEHPSLIKRPIVVTGDKALVGFPPEEVLALL 114
ArsC_family cd02977
Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins ...
 9-113 3.72e-40

Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.


Pssm-ID: 239275  Cd Length: 105  Bit Score: 129.53  E-value: 3.72e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLG--WEALLNTRGTTFRALPEAEKQGLDTAK 86
Cdd:cd02977    1 ITIYGN--PNCSTSRKALAWLEEHGIEYEFIDYLKEPPTKEELKELLAKLGlgVEDLFNTRGTPYRKLGLADKDELSDEE 78

                         90       100
                 ....*....|....*....|....*..
gi 657198595  87 ARDLLLAHPAMIKRPLLDQDGTLTLGF 113
Cdd:cd02977   79 ALELMAEHPKLIKRPIVVDGDRLLVGF 105
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 12-119 2.32e-35

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 117.32  E-value: 2.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   12 YGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKL--GWEALLNTRGTTFRALPEAEKQgLDTAKARD 89
Cdd:pfam03960   1 YGS--PNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLgdGVEALLNTRGTTYRELNLDKED-LSEDELLE 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 657198595   90 LLLAHPAMIKRPLLDQDGTLTLGFKADLYQ 119
Cdd:pfam03960  78 LILEHPSLIRRPIVVDGGKLLVGFNEEEIR 107
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 11-119 9.42e-33

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 110.98  E-value: 9.42e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   11 LYGIspKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKL--GWEALLNTRGTTFRAL-PEAEKQGLDTAKA 87
Cdd:TIGR01617   3 VYGS--PNCTTCKKARRWLEANGIEYQFIDIGEDGPTREELLDILSLLedGIDPLLNTRGQSYRALnTSNTFLDLSDKEA 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 657198595   88 RDLLLAHPAMIKRPLL-DQDGTLTLGFKADLYQ 119
Cdd:TIGR01617  81 LELLAEDPALLRRPLIvDTKNRLLIGFKSESIE 113
ArsC_like cd03036
Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a ...
 17-118 3.34e-18

Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.


Pssm-ID: 239334  Cd Length: 111  Bit Score: 73.82  E-value: 3.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595  17 KNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEA--LLNTRGTTFRALPEAEK-QGLDTAKARDLLLA 93
Cdd:cd03036    7 PKCSTCRKAKKWLDEHGVDYTAIDIVEEPPSKEELKKWLEKSGLPLkkFFNTSGKSYRELGLKDKlPSLSEEEALELLSS 86

                         90       100
                 ....*....|....*....|....*
gi 657198595  94 HPAMIKRPLLDQDGTLTLGFKADLY 118
Cdd:cd03036   87 DGMLIKRPFVVDDDKVLVGFKEEEW 111
ArsC_Spx cd03032
Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding ...
 8-116 1.97e-10

Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex formation between RNAP and certain transcriptional activator proteins like ResD and ComA. In response to oxidative stress, Spx can also activate transcription, making it a general regulator that exerts both positive and negative control over transcription initiation. Spx has been shown to exert redox-sensitive transcriptional control over genes like trxA (TRX) and trxB (TRX reductase), genes that function in thiol homeostasis. This redox-sensitive activity is dependent on the presence of a CXXC motif, present in some members of the Spx subfamily, that acts as a thiol/disulfide switch. Spx has also been shown to repress genes in a sulfate-dependent manner independent of the presence of the CXXC motif.


Pssm-ID: 239330  Cd Length: 115  Bit Score: 53.79  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   8 KVVLYGISpkNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLD--LWLAKLGWEALLNTRGTTFRAL----PEaekqg 81
Cdd:cd03032    1 MIKLYTSP--SCSSCRKAKQWLEEHQIPFEERNLFKQPLTKEELKeiLSLTENGVEDIISTRSKAFKNLnidiDE----- 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 657198595  82 LDTAKARDLLLAHPAMIKRPLLDQDGTLTLGFKAD 116
Cdd:cd03032   74 LSLSELIRLISEHPSLLRRPIIIDEKRLQIGYNED 108
PRK12559 PRK12559
transcriptional regulator Spx; Provisional
 9-124 2.82e-10

transcriptional regulator Spx; Provisional


Pssm-ID: 79035  Cd Length: 131  Bit Score: 53.95  E-value: 2.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYgiSPKNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLD--LWLAKLGWEALLNTRGTTFRALpEAEKQGLDTAK 86
Cdd:PRK12559   2 VVLY--TTASCASCRKAKAWLEENQIDYTEKNIVSNSMTVDELKsiLRLTEEGATEIISTRSKTFQDL-NINIEELSLNE 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 657198595  87 ARDLLLAHPAMIKRPLLDQDGTLTLGFKADLYQSLFSR 124
Cdd:PRK12559  79 FYKLIIEHPLMLRRPIMLDEKRLQIGFNDEEIRKFLPR 116
spxA PRK13344
transcriptional regulator Spx; Reviewed
 9-124 7.43e-08

transcriptional regulator Spx; Reviewed


Pssm-ID: 183988  Cd Length: 132  Bit Score: 47.65  E-value: 7.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYGISpkNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKL--GWEALLNTRGTTFRALpEAEKQGLDTAK 86
Cdd:PRK13344   2 IKIYTIS--SCTSCKKAKTWLNAHQLSYKEQNLGKEPLTKEEILAILTKTenGIESIVSSKNRYAKAL-DCDIEELSVNE 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 657198595  87 ARDLLLAHPAMIKRPLLDQDGTLTLGFKADLYQSLFSR 124
Cdd:PRK13344  79 VIDLIQENPRILKSPILIDDKRLQVGYKEDDIRAFLPR 116
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 18-112 7.55e-08

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


Pssm-ID: 239332  Cd Length: 112  Bit Score: 47.20  E-value: 7.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595  18 NCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEA--LLNTRGTTFRALPEAEKQgLDTAKARDLLLAHP 95
Cdd:cd03034    8 RCSKSRNALALLEEAGIEPEIVEYLKTPPTAAELRELLAKLGISPrdLLRTKEAPYKELGLADPE-LSDEELIDAMAAHP 86

                         90
                 ....*....|....*..
gi 657198595  96 AMIKRPLLDQDGTLTLG 112
Cdd:cd03034   87 ILIERPIVVTGDGAVLG 103
spxA PRK01655
transcriptional regulator Spx; Reviewed
 9-116 1.61e-07

transcriptional regulator Spx; Reviewed


Pssm-ID: 179316  Cd Length: 131  Bit Score: 46.60  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595   9 VVLYgISPkNCDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLD--LWLAKLGWEALLNTRGTTFRALpEAEKQGLDTAK 86
Cdd:PRK01655   2 VTLF-TSP-SCTSCRKAKAWLEEHDIPFTERNIFSSPLTIDEIKqiLRMTEDGTDEIISTRSKVFQKL-NVDVESLSLQD 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 657198595  87 ARDLLLAHPAMIKRPLLDQDGTLTLGFKAD 116
Cdd:PRK01655  79 LIKLISDNPGLLRRPIIIDEKRLQVGYNED 108
ArsC_15kD cd03033
Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown ...
 19-117 1.41e-06

Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also encodes dinitrogenase reductase ADP-ribosyltransferase (DRAT) and dinitrogenase reductase activating glycohydrolase (DRAG). ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239331  Cd Length: 113  Bit Score: 43.81  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198595  19 CDTIKKARKWLEEAGIDYRFHDHRADGLSPEQLDLWLAKLGWEALLNtrgttfRALP-----EAEKQGLDTAKARDLLLA 93
Cdd:cd03033   10 CANNARQKALLEAAGHEVEVRDLLTEPWTAETLRPFFGDLPVAEWFN------PAAPrvksgEVVPEALDEEEALALMIA 83

                         90       100
                 ....*....|....*....|....
gi 657198595  94 HPAMIKRPLLDQDGTLTLGFKADL 117
Cdd:cd03033   84 DPLLIRRPLMQVGDRRMVGFDTAR 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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