|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
1-558 |
0e+00 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 843.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 1 MTVKRPVSGSLAWAFFSIIALSVLTSTVALLTLASSQRDAEAINIAGSLRMQSYRLGYEMQRNSPSLMAHRENWQRTLSA 80
Cdd:PRK10935 1 MMVKRSVTSSIARAMLLIILLSSLTTGFALLTLASSLRDAEAINIAGSLRMQSYRLAYDLQSGSPQLNAHLREFEQSLHS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 81 PSLEKLNRWYVPDNVKARYQQLHVAWLDMDKHIARGDSAWYDAHIEDFVGRIDAFVLALQHYTENKIQTVTLLSLAGALG 160
Cdd:PRK10935 81 PALKNLNRWYVPEDVKDRYALLIARWLEMKSYLEQGDSRWYQANIANYVDQIDLFVLALQHFAERKLILLAAISLLGLIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 161 ILLLTLFTLRRIRRQVVLPLNNLVAASERIERGEFTTPAPDTALPNELGQLSRAFNHMSGELHTLYRSLEASVAEKTRHL 240
Cdd:PRK10935 161 ILTLVFFTVRFTRRQVVAPLNQLVTASQQIEKGQFDHIPLDTTLPNELGLLAKAFNQMSSELHKLYRSLEASVEEKTRKL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 241 HEAHQQLDMLFKCSQALNTGQIDSLCFRHILQIVHEYTQMNYLELRTSDD--WRLCEGTEVSGISLQTLPVLMQDTLYGE 318
Cdd:PRK10935 241 TQANRSLEVLYQCSQALNASQIDVHCFRHILQIVRDHEGLDYLELEVGENehWRISEGQPNPELPWQILPLTMEDTVLGY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 319 LRWQSETGSVPLPLMRSVATMLGRGLYFNQAQKHYQQLLLMEERATIARELHDSLAQVLSYLRIQLTLLKHAVPAENASA 398
Cdd:PRK10935 321 LHWQASLPCPDEPLMNNVAQMLGRGLYFNQAQKQQQQLLLMEERATIARELHDSLAQVLSYLKIQLTLLKRSLDEDNAKA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 399 QTIITDFSRELNNAWQQLRELLTTFRLTLNHANLPAALQESLDALQSQTQAKLHLDCRLSTLALDAQKQVHLLQIVREAV 478
Cdd:PRK10935 401 QSIIAEFDQALSDAYRQLRELLTTFRLTIQEANLGSALEEMLDQLRNQTDAKITLDCRLPSQALDAQQQVHLLQIIREAT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 479 LNAIKHAQASEITVSCVTAVDGTHSVSIRDNGIGIGEASEPPGHYGLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPAP 558
Cdd:PRK10935 481 LNAIKHANASEIAVSCVTNPDGEHTVSIRDDGIGIGELKEPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFPSQ 560
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
35-562 |
6.47e-91 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 290.42 E-value: 6.47e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 35 SSQRDAEAINIAGSLRMQSYRL--GYEMQRNSPSLMAHREnwqRTLSAPsleKLNRWYVPDNVKARYQQLHVAWLD---- 108
Cdd:PRK10600 10 GVQGSAHAINKAGSLRMQSYRLlaAVPLSEKDKPLLKEME---QTAFSP---ELQRAAERDGQLAQLQALQDYWRNelkp 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 109 -MDKHIARGDSAwydAHIEDFVGRIDAFVLALQHYTENKIQTVTLLSLAGALGILLLTLFTLRRIRRQVVLPLNNLVAAS 187
Cdd:PRK10600 84 aLQQAQNPEDVA---ADVAQFVAGLDALVSAFDHTTEMRIETVVLVHRVFAVFMALLLVFTIIWLRRRLLQPWRQLLSMA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 188 ERIERGEFTTPApdtALP--NELGQLSRAFNHMSGELHTLYRSLEASVAEKTRHLHEAHQQLDMLFKCSQALNTGQidSL 265
Cdd:PRK10600 161 NAVSHRDFTQRA---NISgrDEMAMLGTALNNMSAELAESYAVLEQRVQEKTAGLEQKNQILSFLWQANRRLHSRA--PL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 266 CFRH--ILQIVHEYTQMNYLELR----------------------------------------TSDDWRLCEGTEVSGIS 303
Cdd:PRK10600 236 CERLspVLNGLQNLTLLRDIELRvyetddeenhqeftcqsdmtcddkgcqlcprgvlpvgdrgTTLKWRLSDKHGQYGIL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 304 LQTLPV---LMQDtlygelrwQSEtgsvplpLMRSVATMLGRGLYFNQAQKHYQQLLLMEERATIARELHDSLAQVLSYL 380
Cdd:PRK10600 316 LATLPQgrhLSHD--------QQQ-------LVDTLVEQLTATLALERQQERQQQLIVMEERATIARELHDSIAQSLSCM 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 381 RIQLTLLKHAVPAENASAQTIITDFSRELNNAWQQLRELLTTFRLTLNHANLPAALQESLDALQSQTQAKLHLDCRLSTL 460
Cdd:PRK10600 381 KMQVSCLQMQGDALPESSRELLSQIRNELNASWRQLRELLTTFRLQLTEPGLRPALEASCEEFSARFGFPVKLDYQLPPR 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 461 ALDAQKQVHLLQIVREAVLNAIKHAQASEITVScVTAVDGTHSVSIRDNGIGIGEASEPPGHYGLNIMRERAQRLGGMLH 540
Cdd:PRK10600 461 LVPSHQAIHLLQIAREALSNALKHAQASEVVVT-VAQNQNQVKLSVQDNGCGVPENAERSNHYGLIIMRDRAQSLRGDCR 539
|
570 580
....*....|....*....|..
gi 654546307 541 FSQPQNGGTQVSVTFPAPAPLT 562
Cdd:PRK10600 540 VRRRESGGTEVVVTFIPEKTFT 561
|
|
| NarQ_sensor |
cd22899 |
ligand binding sensor domain of NarQ, and related chemoreceptors; The periplasmic ligand ... |
34-149 |
6.75e-57 |
|
ligand binding sensor domain of NarQ, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarQ-NarP sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarQ has been shown to interact equally with NarP and NarL response regulators; NarL is the sensor response partner of NarX.
Pssm-ID: 438631 [Multi-domain] Cd Length: 116 Bit Score: 186.19 E-value: 6.75e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 34 ASSQRDAEAINIAGSLRMQSYRLGYEMQRNSPSLMAHRENWQRTLSAPSLEKLNRWYVPDNVKARYQQLHVAWLDMDKHI 113
Cdd:cd22899 1 ASSLSDAEAINVAGSLRMQSYRLAYDLESESPLLEQHIAQYEQSLHSPALQSLDRWYVPDEVKQRYQQLLARWQEMKQYL 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 654546307 114 ARGDSAWYDAHIEDFVGRIDAFVLALQHYTENKIQT 149
Cdd:cd22899 81 LQGDPASYLQQVASYVDQIDQFVLALQHFAERKLRL 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
348-560 |
1.50e-46 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 163.64 E-value: 1.50e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 348 QAQKHYQQLLLMEERATIARELHDSLAQVLSYLRIQLTLLKHAVPAENASAQTIITDFSRELNNAWQQLRELLTTFR-LT 426
Cdd:COG4585 40 RELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGLRpPA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 427 LNHANLPAALQESLDALQSQTQAKLHLDCRLSTLALDAQKQVHLLQIVREAVLNAIKHAQASEITVScVTAVDGTHSVSI 506
Cdd:COG4585 120 LDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVT-LEVDDGELTLTV 198
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 654546307 507 RDNGIGIGEASEPPGHYGLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPAPAP 560
Cdd:COG4585 199 RDDGVGFDPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-556 |
5.02e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 107.25 E-value: 5.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 470 LLQIVREAVLNAIKHAQASEITVSCVTAVDGTHsVSIRDNGIGIGEASEPPG-HYGLNIMRERAQRLGGMLHFSQPQNGG 548
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTLSYTADELT-LTVVDDGVGFDGPAPPGGgGFGLLGMRERAELLGGTLTIGSRPGGG 79
|
....*...
gi 654546307 549 TQVSVTFP 556
Cdd:cd16917 80 TRVTARLP 87
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
347-562 |
2.18e-27 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 115.49 E-value: 2.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 347 NQAQKHYQQLLLMEE--RATIARELHDSLAQVLSYLRIQLTLLKHAVPAENA--SAQTIitdfSRELNNAWQQLRELLTT 422
Cdd:COG3851 276 RENRALARQLVSAEEseRREIARELHDEIGQNITAIRTQASILKRLAPQPEIeqSAQSI----ESLALRIYDTTRRLLDR 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 423 FR-LTLNHANLPAALQESLDALQSQTQA-KLHLDCRLSTLALDAQKQVHLLQIVREAVLNAIKHAQASEITVScVTAVDG 500
Cdd:COG3851 352 LRpAVLDELGLEEALRELPRELAFEEPGiSCQLDLRGDPSLLDDTLQLTLYRLVQEALTNILKHAEASQIRIS-LSQDKR 430
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654546307 501 THSVSIRDNGIGIGeASEPPGHYGLNIMRERAQRLGGMLHFSqPQNGGTQVSVTFPAPAPLT 562
Cdd:COG3851 431 LLSLEIRDDGIGLP-PELRAKGFGLRGMRERVRALGGDFRLS-SAPKGTRLSVLLPTPAASN 490
|
|
| NarX_NarQ_sensor |
cd19408 |
ligand binding sensor domain of NarX and NarQ, and related chemoreceptors; The periplasmic ... |
35-149 |
5.25e-27 |
|
ligand binding sensor domain of NarX and NarQ, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarX and NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair, along with NarQ-NarP, control Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, whereas NarQ exhibits a relatively slight kinetic preference for NarL. There is asymmetry in the Nar cross-regulation network with NarQ shown to interact similarly with both response regulators, while NarX interacts preferentially with NarL.
Pssm-ID: 438626 [Multi-domain] Cd Length: 126 Bit Score: 105.79 E-value: 5.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 35 SSQRDAEAINIAGSLRMQSYRLGYEMQRN----SPSLMAHRENWQRTLSAPSLEKLNRWYVPDNVKARYQQLHVAWLDM- 109
Cdd:cd19408 2 STEGDAAAINLAGSLRMQSYRLASLLLQAalepAEQLAQLIDEFEQRLNSPALTRALPRDSDHPLRQAYQAVLQHWQQEl 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 654546307 110 -----DKHIARGDSAWYDAHIEDFVGRIDAFVLALQHYTENKIQT 149
Cdd:cd19408 82 rpaleAAASGAADREAYLAEVDEFVAQIDQLVKLLQQDTEAKIRL 126
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
354-556 |
1.39e-23 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 104.29 E-value: 1.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 354 QQLLLMEE--RATIARELHDSLAQVLSYLRIQLTLLKHAVPAE---NASAQTIITdfsreLN-NAWQQLRELLTTFR-LT 426
Cdd:PRK11644 292 ERLLETEEsvRRDVARELHDEIGQTITAIRTQAGIIKRLAADNasvKQSAQLIEQ-----LSlGVYDTVRRLLGRLRpRQ 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 427 LNHANLPAALQESLDALQSQTQAKL-HLDCRLSTLALDAQKQVHLLQIVREAVLNAIKHAQASEITVScVTAVDGTHSVS 505
Cdd:PRK11644 367 LDDLTLEQAIRSLMREMELEDRGIVsHLDWRIDESALSETQRVTLFRVCQEGLNNIVKHADASAVTLQ-GWQQDERLMLV 445
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 654546307 506 IRDNGIGIGEASEPPGhYGLNIMRERAQRLGGMLHFSQPQngGTQVSVTFP 556
Cdd:PRK11644 446 IEDDGSGLPPGSGQQG-FGLRGMRERVTALGGTLTISCTH--GTRLSVSLP 493
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
467-556 |
7.41e-17 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 76.53 E-value: 7.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 467 QVHLLQIVREAVLNAIKHAQA-SEITVScVTAVDGTHSVSIRDNGIGI----------------GEASEPPGH-YGLNIM 528
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEgGRITVT-LERDGDHVEITVEDNGPGIppedlekifepffrtdKRSRKIGGTgLGLSIV 81
|
90 100
....*....|....*....|....*...
gi 654546307 529 RERAQRLGGMLHFSQPQNGGTQVSVTFP 556
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
466-558 |
9.63e-17 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 76.25 E-value: 9.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 466 KQVHLLQIVREAVLNAIKHA-QASEITVSCVTavDGTHSVSIRDNGIGI--------------GEASEPPGH-YGLNIMR 529
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAaKAGEITVTLSE--GGELTLTVEDNGIGIppedlprifepfstADKRGGGGTgLGLSIVR 79
|
90 100
....*....|....*....|....*....
gi 654546307 530 ERAQRLGGMLHFSQPQNGGTQVSVTFPAP 558
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PilJ |
pfam13675 |
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ... |
32-126 |
1.21e-14 |
|
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433397 [Multi-domain] Cd Length: 112 Bit Score: 70.20 E-value: 1.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 32 TLASSQRDAEAINIAGSLRMQSYRLG----------YEMQRNSPSLMAHRENWQRTLSAPSLEKLNR-WYVPDN-VKARY 99
Cdd:pfam13675 2 TLWQSEGDAAAINAAGSLRMQSQRLAksvllalagnYDLAEAFADLEESIDQFDRTLAALALGDLARgLFVPAGaIRAQL 81
|
90 100 110
....*....|....*....|....*....|.
gi 654546307 100 QQLHVAWLDMDKHIAR----GDSAWYDAHIE 126
Cdd:pfam13675 82 EAVQPLWERLRKPAEAvlaqQDTLAYLAAVL 112
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
171-560 |
4.17e-14 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 74.61 E-value: 4.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 171 RIRRQVVLPLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGELhtlyrsleasvAEKTRHLHEAHQQLDML 250
Cdd:COG5000 28 LLARRLTRPLRRLAEATRAVAAGDLSVRLPVTG-DDEIGELARAFNRMTDQL-----------KEQREELEERRRYLETI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 251 FkcsQALNTGQIDSLCFRHILQIVHEYTQMnyleLRTSDDWRLceGTEVSGI-SLQTLPVLMQDTLygELRWQSE---TG 326
Cdd:COG5000 96 L---ENLPAGVIVLDADGRITLANPAAERL----LGIPLEELI--GKPLEELlPELDLAELLREAL--ERGWQEEielTR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 327 SVPLPLMRSVATMLGRG--LYFNQaqkhYQQLLLMEERATIARelhdsLAQVLSY-LR-----IQLT--LLKHAVPAENA 396
Cdd:COG5000 165 DGRRTLLVRASPLRDDGyvIVFDD----ITELLRAERLAAWGE-----LARRIAHeIKnpltpIQLSaeRLRRKLADKLE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 397 SAQTIITDFSRELNNAWQQLRELLTTFR-------LTLNHANLPAALQESLDALQSQTQAK-----LHLDCRLSTLALDA 464
Cdd:COG5000 236 EDREDLERALDTIIRQVDRLKRIVDEFLdfarlpePQLEPVDLNELLREVLALYEPALKEKdirleLDLDPDLPEVLADR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 465 QkqvHLLQIVREAVLNAIKHAQAS-EITVScVTAVDGTHSVSIRDNGIGIGE-----ASEPpghY----------GLNIM 528
Cdd:COG5000 316 D---QLEQVLINLLKNAIEAIEEGgEIEVS-TRREDGRVRIEVSDNGPGIPEevlerIFEP---FfttkpkgtglGLAIV 388
|
410 420 430
....*....|....*....|....*....|..
gi 654546307 529 RERAQRLGGMLHFSQPQNGGTQVSVTFPAPAP 560
Cdd:COG5000 389 KKIVEEHGGTIELESRPGGGTTFTIRLPLAEE 420
|
|
| HisKA_3 |
pfam07730 |
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ... |
361-424 |
5.59e-13 |
|
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.
Pssm-ID: 429624 [Multi-domain] Cd Length: 68 Bit Score: 63.79 E-value: 5.59e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 654546307 361 ERATIARELHDSLAQVLSYLRIQLTLLKHAVPAENASAQTIITDFSRELNNAWQQLRELLTTFR 424
Cdd:pfam07730 1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDPEEAREQLDAIRELAREALQELRRLLGDLR 64
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
470-555 |
8.70e-13 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 64.55 E-value: 8.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 470 LLQIVREAVLNAIKHA-QASEITVScVTAVDGTHSVSIRDNGIGI--------------GEASEPPGHY--GLNIMRERA 532
Cdd:cd00075 1 LEQVLSNLLDNALKYSpPGGTIEIS-LRQEGDGVVLEVEDNGPGIpeedleriferfyrGDKSREGGGTglGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 654546307 533 QRLGGMLHFSQPQNGGTQVSVTF 555
Cdd:cd00075 80 EAHGGRITVESEPGGGTTFTVTL 102
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
348-560 |
1.40e-12 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 67.62 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 348 QAQKHYQQLLLMEER-----ATIARELHDSLAQVLSYLriqlTLLKHAVPAENASAQTIITDFSRELNNAWQQLRELLT- 421
Cdd:COG2205 1 ELEEALEELEELERLkseflANVSHELRTPLTSILGAA----ELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDl 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 422 ------TFRLTLNHANLPAALQESLDALQSQTQAK-----LHLDCRLSTLALDAqkqVHLLQIVREAVLNAIKHAQA-SE 489
Cdd:COG2205 77 srlesgKLSLELEPVDLAELLEEAVEELRPLAEEKgirleLDLPPELPLVYADP---ELLEQVLANLLDNAIKYSPPgGT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 490 ITVScVTAVDGTHSVSIRDNGIGIGEA---------------SEPPGH-YGLNIMRERAQRLGGMLHFSQPQNGGTQVSV 553
Cdd:COG2205 154 ITIS-ARREGDGVRISVSDNGPGIPEEeleriferfyrgdnsRGEGGTgLGLAIVKRIVEAHGGTIWVESEPGGGTTFTV 232
|
....*..
gi 654546307 554 TFPAPAP 560
Cdd:COG2205 233 TLPLAES 239
|
|
| NarX_sensor |
cd22900 |
ligand binding sensor domain of NarX, and related chemoreceptors; The periplasmic ligand ... |
35-151 |
4.72e-11 |
|
ligand binding sensor domain of NarX, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarX is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, the sensor response partner of NarQ.
Pssm-ID: 438632 [Multi-domain] Cd Length: 116 Bit Score: 59.88 E-value: 4.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 35 SSQRDAEAINIAGSLRMQSYRLGYE--MQRNSPSLMAHRENwqrTLSAPSLEKLNRwyvPDNVKARYQQLHVAWLDMDKH 112
Cdd:cd22900 2 SIQGNAHAINKAGSLRMQSYRLLAAvpLNPQDQALLDELEQ---TLSSPELQRAAR---REGLQSQLQALQQYWQQQLKP 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 654546307 113 IAR--GDSAWYDAHIEDFVGRIDAFVLALQHYTENKIQTVT 151
Cdd:cd22900 76 ALLaaKNPEDARAEVAAFVAQLDQLVSQIDQKTEQRLSLIS 116
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
377-558 |
6.03e-11 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 63.77 E-value: 6.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 377 LSYLRIQLTLLKHAVPAENASAQTIITDFSRELNnawQQLRELLT-------TFRLTLNHANLPAALQESLDALQSQTQA 449
Cdd:COG0642 125 LTAIRGYLELLLEELDEEQREYLETILRSADRLL---RLINDLLDlsrleagKLELEPEPVDLAELLEEVVELFRPLAEE 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 450 K-----LHLDCRLSTLALDAQKqvhLLQIVREAVLNAIKHAQA-SEITVScVTAVDGTHSVSIRDNGIGIGEA------- 516
Cdd:COG0642 202 KgieleLDLPDDLPTVRGDPDR---LRQVLLNLLSNAIKYTPEgGTVTVS-VRREGDRVRISVEDTGPGIPPEdlerife 277
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 654546307 517 ----SEPPGHY-----GLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPAP 558
Cdd:COG0642 278 pffrTDPSRRGggtglGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
358-559 |
3.48e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 62.62 E-value: 3.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 358 LMEERATIARELH----DSLAQVLSYLRIQltllkhAVPAENASAQTIITDFSRELNnAWQQLRELLTTfRLTLNHANLP 433
Cdd:COG3920 291 SLEEKELLLRELHhrvkNNLQVVSSLLRLQ------ARRADDPEAREALEESQNRIQ-ALALVHELLYQ-SEDWEGVDLR 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 434 AALQESLDAL-QSQTQAKLHLDCRLSTLALDAQKQVHLLQIVREAVLNAIKHAQAS----EITVSCvTAVDGTHSVSIRD 508
Cdd:COG3920 363 DYLRELLEPLrDSYGGRGIRIELDGPDVELPADAAVPLGLILNELVTNALKHAFLSgeggRIRVSW-RREDGRLRLTVSD 441
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 654546307 509 NGIGIGEASEPPGH--YGLNIMRERAQRLGGMLHFSQPQngGTQVSVTFPAPA 559
Cdd:COG3920 442 NGVGLPEDVDPPARkgLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLAE 492
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
174-227 |
8.77e-10 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 54.56 E-value: 8.77e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 654546307 174 RQVVLPLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGELHTLYR 227
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDG-RDEIGELARAFNEMADRLEETIA 53
|
|
| HAMP |
pfam00672 |
HAMP domain; |
171-224 |
1.59e-09 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 53.78 E-value: 1.59e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 654546307 171 RIRRQVVLPLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGELHT 224
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSG-RDEIGELARAFNQMAERLRE 53
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
442-556 |
4.09e-09 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 58.71 E-value: 4.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 442 ALQSQTQAKLHLDCRLSTLALDAQkqvHLLQIVREAVLNAIKHAQASE-----ITVScVTAVDGTHSVSIRDNGIGIGEA 516
Cdd:COG3290 257 ARERGIDLTIDIDSDLPDLPLSDT---DLVTILGNLLDNAIEAVEKLPeeerrVELS-IRDDGDELVIEVEDSGPGIPEE 332
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 654546307 517 ----------SEPPGH---YGLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFP 556
Cdd:COG3290 333 llekifergfSTKLGEgrgLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
179-222 |
5.85e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 51.68 E-value: 5.85e-09
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 654546307 179 PLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGEL 222
Cdd:cd06225 3 PLRRLTEAARRIAEGDLDVRVPVRS-KDEIGELARAFNQMAERL 45
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
170-384 |
3.14e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 56.05 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 170 RRIRRQVVLPLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGELHTLYRSLEASVAEKTRHLHEAHQQLDM 249
Cdd:COG3850 136 YLLRRRIVRPLRRLTQAAERIARGDFDARVPVSG-RDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 250 LFKCSQALNTGQIDSLCFRHILQIVHEYTQMNYLELRTSDDW--RLCEGTEVSGISLQTLPVLMQDTLYGELRWQSETGS 327
Cdd:COG3850 215 LLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALniLAGLLELLLALLLLLLASALLLLELELLALLLELVE 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 654546307 328 VPLPLMRSVATMLGRGLYFNQAQKHYQQLLLMEERATIARELHDSLAQVLSYLRIQL 384
Cdd:COG3850 295 LLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQA 351
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
431-557 |
8.69e-08 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 54.56 E-value: 8.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 431 NLPAALQESLDALQSQTQAK---LHLDCRLSTLALDAQKQvHLLQIVREAVLNAIKHAQA-SEITVScVTAVDGTHSVSI 506
Cdd:COG5002 241 DLAELLEEVVEELRPLAEEKgieLELDLPEDPLLVLGDPD-RLEQVLTNLLDNAIKYTPEgGTITVS-LREEDDQVRISV 318
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 654546307 507 RDNGIGIgeasePPGH--------Y---------------GLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPA 557
Cdd:COG5002 319 RDTGIGI-----PEEDlpriferfYrvdksrsretggtglGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
457-556 |
2.99e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 49.53 E-value: 2.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 457 LSTLALDAQKQVHLLQIVREAVLNAIKHAQAS----EITVSCvTAVDGTHSVSIRDNGIGI-------GEASEPPGHYGL 525
Cdd:COG2172 22 LRELGLDEDDADDLVLAVSEAVTNAVRHAYGGdpdgPVEVEL-ELDPDGLEIEVRDEGPGFdpedlpdPYSTLAEGGRGL 100
|
90 100 110
....*....|....*....|....*....|..
gi 654546307 526 NIMReraqRLggMLHFS-QPQNGGTQVSVTFP 556
Cdd:COG2172 101 FLIR----RL--MDEVEyESDPGGTTVRLVKR 126
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
459-556 |
5.52e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 48.95 E-value: 5.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 459 TLALDAQKQVHLLQIVREAVLNAIKHA--QASEITVSCVTAVDGTHS-VSIRDNGIGIGEASEPP--GHYGLNIMRERAQ 533
Cdd:cd16951 29 TGPVSSEVATAIGLVVNELLQNALKHAfsDREGGTITIRSVVDGDYLrITVIDDGVGLPQDEDWPnkGSLGLQIVRSLVE 108
|
90 100
....*....|....*....|...
gi 654546307 534 RLGGMLHFSQPQNGGTQVSVTFP 556
Cdd:cd16951 109 GELKAFLEVQSAENGTRVNIDIP 131
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
172-246 |
1.49e-06 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 51.18 E-value: 1.49e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 654546307 172 IRRQVVLPLNNLVAaseRIerGEFTTPAPDTALP----NELGQLSRAFNHMSGELHTLYRSLEASVAEKTRHLHEAHQQ 246
Cdd:PRK15347 317 LRRYLAKPLWRFVD---II--NKTGPAALEPRLPenrlDELGSIAKAYNQLLDTLNEQYDTLENKVAERTQALAEAKQR 390
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
480-556 |
2.20e-06 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 49.87 E-value: 2.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 480 NAIKHAQAS-----EITVScVTAVDGTHSVSIRDNGIGIGEASEPPGH-YGLNIMRERAQRLGGM---LHFSQPQNGGTQ 550
Cdd:COG3275 264 NAIKHGISSkegggTISIS-IEVEGDRLVIEVENNGVGIQPKKKKKGSgIGLKNVRERLELLYGDkysLEIESTDGGGTK 342
|
....*.
gi 654546307 551 VSVTFP 556
Cdd:COG3275 343 VTLKIP 348
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
347-557 |
3.68e-06 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 49.41 E-value: 3.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 347 NQAQKHYQQLLLMEER--------ATIArelHDsLAQVLSYLRIQLTLLKHAV--PAENASAQTIITDFSRELNNAWQQL 416
Cdd:COG4191 123 EEELRELQEQLVQSEKlaalgelaAGIA---HE-INNPLAAILGNAELLRRRLedEPDPEELREALERILEGAERAAEIV 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 417 RELLTTFR---LTLNHANLPAALQESLDALQSQTQAK-----LHLDCRLSTLALDAQ--KQVhLLQIVREAvLNAIKHAQ 486
Cdd:COG4191 199 RSLRAFSRrdeEEREPVDLNELIDEALELLRPRLKARgieveLDLPPDLPPVLGDPGqlEQV-LLNLLINA-IDAMEEGE 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 487 ASEITVScVTAVDGTHSVSIRDNGIGIGEAS-----EP------PGH---YGLNIMRERAQRLGGMLHFSQPQNGGTQVS 552
Cdd:COG4191 277 GGRITIS-TRREGDYVVISVRDNGPGIPPEVlerifEPffttkpVGKgtgLGLSISYGIVEKHGGRIEVESEPGGGTTFT 355
|
....*
gi 654546307 553 VTFPA 557
Cdd:COG4191 356 ITLPL 360
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-556 |
4.85e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 45.49 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 470 LLQIVREavlNAIKHA-----QASEITVsCVTAVDGTHSVSIRDNGIGIGE-----------ASEPPGHYGLNIMRERAQ 533
Cdd:cd16957 5 ALQVLVE---NAIRHAfpkrkENNEVRV-VVKKDQHKVHVSVSDNGQGIPEerldllgkttvTSEKGTGTALENLNRRLI 80
|
90 100
....*....|....*....|....*.
gi 654546307 534 RLGG---MLHFSQPQNGGTQVSVTFP 556
Cdd:cd16957 81 GLFGseaCLHIESEVHGGTEVWFVIP 106
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
95-560 |
8.21e-06 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 48.63 E-value: 8.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 95 VKARYQQLHVAWLDMDKHIARGDSAWYDAHIEDFVGRIDAFVLALQHYTENKIQTVTLLSLAGALGILLLTLFTLRRIRR 174
Cdd:COG4251 1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 175 QVVLPLNNLVAASERIERGEFTTPAPDTALPNELGQLSRAFNHMSGELHTLYRSLEASVAEKTRHLHEAHQQLDMLFKCS 254
Cdd:COG4251 81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 255 QALNTGQIDSLCFRHILQIVHEYTQMNYLELRTSDDWRLCEGTEVSGISLQTLPVLMQDTLYGELRWQSETGSVPLPLMR 334
Cdd:COG4251 161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 335 SVATMLGRGLYFNQAQKHYQQLLLMEERATIAREL---------------HD---SLAQVLSYLRIQLTLLKHAVPAE-- 394
Cdd:COG4251 241 LILLLLLLILVLELLELRLELEELEEELEERTAELersneeleqfayvasHDlrePLRKISGFSQLLEEDYGDKLDEEgr 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 395 ------NASA---QTIITD---FSRelnnawqqlrelLTTFRLTLNHANLPAALQESLDALQ---SQTQAKLHLDcRLST 459
Cdd:COG4251 321 eyleriRDAAermQALIDDllaYSR------------VGRQELEFEPVDLNELLEEVLEDLEpriEERGAEIEVG-PLPT 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 460 LALDAqkqVHLLQIVREAVLNAIKHAQASE---ITVSCVTAvDGTHSVSIRDNGIGIGEA---------------SEPPG 521
Cdd:COG4251 388 VRGDP---TLLRQVFQNLISNAIKYSRPGEpprIEIGAERE-GGEWVFSVRDNGIGIDPEyaekifeifqrlhsrDEYEG 463
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 654546307 522 H-YGLNIMRERAQRLGGMLHF-SQPqNGGTQVSVTFPAPAP 560
Cdd:COG4251 464 TgIGLAIVKKIVERHGGRIWVeSEP-GEGATFYFTLPKAPA 503
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
172-247 |
2.99e-05 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 46.94 E-value: 2.99e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654546307 172 IRRQVVLPLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGELhtlyRSLEASVAEKTRHLHEAHQQL 247
Cdd:COG0840 202 LSRSITRPLRELLEVLERIAEGDLTVRIDVDS-KDEIGQLADAFNRMIENL----RELVGQVRESAEQVASASEEL 272
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
431-559 |
4.38e-05 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 45.99 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 431 NLPAALQESLDALQSQTQAKlHLDCRLSTLALDAQKQVHLLqivREAVLNAIKHA-----QASEITVSCvTAVDGTHSVS 505
Cdd:PRK11100 330 ALAALLEELVEAREAQAAAK-GITLRLRPDDARVLGDPFLL---RQALGNLLDNAidfspEGGTITLSA-EVDGEQVALS 404
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654546307 506 IRDNGIGIGE-ASE-----------PPGH-----YGLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPAPA 559
Cdd:PRK11100 405 VEDQGPGIPDyALPriferfyslprPANGrkstgLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
343-556 |
1.28e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 44.62 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 343 GLYFNQAQKHYQQLllMEERATIARELHDslAQvLSYLRIQL----------TLLKHAVPAENASAQTIITDFSRELNNA 412
Cdd:COG2972 215 ARSFNEMVERIKEL--IEEVYELELEKKE--AE-LKALQAQInphflfntlnSIRWLAELEDPEEAEEMLEALSKLLRYS 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 413 WQQLRELlTTFRLTLNHanlpaaLQESLDALQSQTQAKLHLDCRLSTLALDAQKQVHLLQIVREavlNAIKHA-----QA 487
Cdd:COG2972 290 LSKGDEL-VTLEEELEL------IKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVE---NAIEHGiepkeGG 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 488 SEITVScVTAVDGTHSVSIRDNGIGIGEA-----------SEPPGHYGLNIMRERAQRLGGM---LHFSQPQNGGTQVSV 553
Cdd:COG2972 360 GTIRIS-IRKEGDRLVITVEDNGVGMPEEkleklleelssKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTI 438
|
...
gi 654546307 554 TFP 556
Cdd:COG2972 439 RIP 441
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
172-443 |
1.80e-04 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 44.33 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 172 IRRQVVLPLNNLVAASERIERGEFTTPAPDTAlPNELGQLSRAFNHMSGELHTLYRSLEASVAEKTRHLHEAHQQLDMLF 251
Cdd:COG2770 232 LARRITRPLRRLAEAARRIAAGDLDVRIPVSR-KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 252 KCSQALNTGQIDSLCFRHILQIVHEYTQMNYLELRTSDDWRLCEGTEVSGISLQTLPVLMQDTLYGELRWQSETGSVPLP 331
Cdd:COG2770 311 LALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAA 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 332 LMRSVATMLGRGLYFNQAQKHYQQLLLMEERATIARELHDSLAQVLSYLRIQLTLLKHAVPAENASAQTIITDFSRELNN 411
Cdd:COG2770 391 VLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAE 470
|
250 260 270
....*....|....*....|....*....|..
gi 654546307 412 AWQQLRELLTTFRLTLNHANLPAALQESLDAL 443
Cdd:COG2770 471 ALLLLAALLLLAALGALELLLLEEEEEAGAAA 502
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
473-555 |
8.35e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.79 E-value: 8.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 473 IVREAVLNAIKHAQAS----EITVSCvTAVDGTHSVSIRDNGIGIG-------EASEPPGHYGLNIMRERAQRLGgmlhf 541
Cdd:cd16936 4 AVSEAVTNAVRHAYRHdgpgPVRLEL-DLDPDRLRVEVTDSGPGFDplrpadpDAGLREGGRGLALIRALMDEVG----- 77
|
90
....*....|....
gi 654546307 542 SQPQNGGTQVSVTF 555
Cdd:cd16936 78 YRRTPGGKTVWLEL 91
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
466-556 |
8.35e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 38.92 E-value: 8.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 466 KQVhLLQIVREAVlNAIKHAQAS--EITVSCVTAVDGTHSVSIRDNGIGIGEA-----------SEPPG-HYGLNIMRER 531
Cdd:cd16920 2 QQV-LINLVRNGI-EAMSEGGCErrELTIRTSPADDRAVTISVKDTGPGIAEEvagqlfdpfytTKSEGlGMGLSICRSI 79
|
90 100
....*....|....*....|....*
gi 654546307 532 AQRLGGMLHFSQPQNGGTQVSVTFP 556
Cdd:cd16920 80 IEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
172-271 |
1.34e-03 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 41.54 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 172 IRRQVVLPLNNLVAASERIERGEFTTPAPDTalPNELGQLSRAFNHMSGElhtlYRSLEASVAEKTRHLHEAhqQLDMLf 251
Cdd:COG2972 177 LSRSITRPIKRLKKAMKKVEKGDLVRLEVSG--NDEIGILARSFNEMVER----IKELIEEVYELELEKKEA--ELKAL- 247
|
90 100
....*....|....*....|
gi 654546307 252 kcsQAlntgQIdslcFRHIL 271
Cdd:COG2972 248 ---QA----QI----NPHFL 256
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
462-556 |
1.52e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 41.58 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 462 LDAQKQVHLLQIVREAVLNAIKHA----QASEITVSCVTAVDGTHSVSIRDNGIGIG-----EASEPpghYGLNIMRERA 532
Cdd:PRK13560 704 LDIDKAIPCGLIISELLSNALKHAfpdgAAGNIKVEIREQGDGMVNLCVADDGIGLPagfdfRAAET---LGLQLVCALV 780
|
90 100
....*....|....*....|....
gi 654546307 533 QRLGGMLhfSQPQNGGTQVSVTFP 556
Cdd:PRK13560 781 KQLDGEI--ALDSRGGARFNIRFP 802
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
470-556 |
1.91e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 38.24 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 470 LLQIVREAVLNAIKHAQASEITVSC-VTAVDGTH---SVSIRDNGIGIGEAS-----EP----PGHY---------GLNI 527
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVsLEEEEEDGvqlRFSVEDTGIGIPEEQqarlfEPfsqaDSSTtrkyggtglGLAI 80
|
90 100
....*....|....*....|....*....
gi 654546307 528 MRERAQRLGGMLHFSQPQNGGTQVSVTFP 556
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
438-560 |
3.33e-03 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 40.31 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 438 ESLDALQS-QTQAKLHLDCRLStlaLDAQKQV---HLLQIVREAVLNAIKHAQASEITVSCVTAVDGTHSVSIRDNGIGI 513
Cdd:PRK11091 366 ENLSGLQAeQKGLRFDLEPLLP---LPHKVITdgtRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLTFEVEDSGIGI 442
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654546307 514 GE------------ASEPPGH-------YGLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPAPAP 560
Cdd:PRK11091 443 PEdeldkifamyyqVKDSHGGkpatgtgIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAV 508
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
446-558 |
5.43e-03 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 39.33 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546307 446 QTQAKLHlDCRLSTLALDAQKQVHL--LQIvREAVLNAIKHA-----QASEITVScVTAVDGTHSVSIRDNGIGIGEA-- 516
Cdd:COG5805 368 ETEAILH-NIQIRLELLDEDPFIYCdeNQI-KQVFINLIKNAieampNGGTITIH-TEEEDNSVIIRVIDEGIGIPEErl 444
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 654546307 517 ---SEP--------PGhYGLNIMRERAQRLGGMLHFSQPQNGGTQVSVTFPAP 558
Cdd:COG5805 445 kklGEPffttkekgTG-LGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| |
