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Conserved domains on  [gi|651883665|ref|WP_026643376|]
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MULTISPECIES: dihydroxy-acid dehydratase [Bifidobacterium]

Protein Classification

dihydroxy-acid dehydratase( domain architecture ID 10013972)

dihydroxy-acid dehydratase catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis

EC:  4.2.1.9
Gene Symbol:  ilvD
PubMed:  35263023|12242394

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
1-614 0e+00

dihydroxy-acid dehydratase; Provisional


:

Pssm-ID: 237104  Cd Length: 615  Bit Score: 1158.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   1 MEMRSAKIMNGRIFAGARALYRAAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDD 80
Cdd:PRK12448   1 PKYRSRTTTHGRNMAGARALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  81 GIAMGHTGMLYSLPSREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTVLPDGTVK 160
Cdd:PRK12448  81 GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKIIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 161 enTDLIDVMYASADDNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTV 240
Cdd:PRK12448 161 --LDLVDAMVAAADPSVSDEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 241 VDIANRYYQHDDESVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPS-G 319
Cdd:PRK12448 239 VELAKRYYEQDDESVLPRSIATKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNtQ 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 320 EWEISDVHRAGGITGILGELDRAGKLHRDVHSVDYPSLEAKLADWDIMRdTCTEEARDFFKAAPGHIVSPEPWTHETTFE 399
Cdd:PRK12448 319 KYHMEDVHRAGGIMGILGELDRAGLLHTDVPTVHGLTLGEALDQWDIMR-TQDEAVKEFFRAAPGGIRTTVAFSQDCRWD 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 400 SLDTDRVNGAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALII 479
Cdd:PRK12448 398 SLDTDRENGCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGGKVKAGDVVVI 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 480 RYEGPKGGPGMQEMLYPTSFVKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINV 559
Cdd:PRK12448 478 RYEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINL 557
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 651883665 560 ELSDEELAERRAKLEAGDGYV---AHRDRQVSQALKAFAAFARSADKGATRDPELINK 614
Cdd:PRK12448 558 LVSDEELAARRAAQEARGDKAwkpKNRERKVSFALKAYAALATSADKGAVRDKSKLGG 615
 
Name Accession Description Interval E-value
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
1-614 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237104  Cd Length: 615  Bit Score: 1158.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   1 MEMRSAKIMNGRIFAGARALYRAAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDD 80
Cdd:PRK12448   1 PKYRSRTTTHGRNMAGARALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  81 GIAMGHTGMLYSLPSREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTVLPDGTVK 160
Cdd:PRK12448  81 GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKIIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 161 enTDLIDVMYASADDNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTV 240
Cdd:PRK12448 161 --LDLVDAMVAAADPSVSDEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 241 VDIANRYYQHDDESVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPS-G 319
Cdd:PRK12448 239 VELAKRYYEQDDESVLPRSIATKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNtQ 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 320 EWEISDVHRAGGITGILGELDRAGKLHRDVHSVDYPSLEAKLADWDIMRdTCTEEARDFFKAAPGHIVSPEPWTHETTFE 399
Cdd:PRK12448 319 KYHMEDVHRAGGIMGILGELDRAGLLHTDVPTVHGLTLGEALDQWDIMR-TQDEAVKEFFRAAPGGIRTTVAFSQDCRWD 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 400 SLDTDRVNGAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALII 479
Cdd:PRK12448 398 SLDTDRENGCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGGKVKAGDVVVI 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 480 RYEGPKGGPGMQEMLYPTSFVKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINV 559
Cdd:PRK12448 478 RYEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINL 557
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 651883665 560 ELSDEELAERRAKLEAGDGYV---AHRDRQVSQALKAFAAFARSADKGATRDPELINK 614
Cdd:PRK12448 558 LVSDEELAARRAAQEARGDKAwkpKNRERKVSFALKAYAALATSADKGAVRDKSKLGG 615
IlvD COG0129
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
1-610 0e+00

Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439899  Cd Length: 558  Bit Score: 884.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   1 MEMRSAKIMNGRIFAGARALYRAAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDD 80
Cdd:COG0129    2 PKMRSDTVTKGRERAPARALLRATGLTDEDFGKPIIGIANSWNEIVPGHVHLDDLAEAVKEGIRAAGGVPFEFNTIAVSD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  81 GIAMGHTGMLYSLPSREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTvlpDGTVK 160
Cdd:COG0129   82 GIAMGHEGMRYSLPSRELIADSIETMVNAHCFDGLVCIPGCDKITPGMLMAAARLNIPSIFVYGGPMLPGKY---DGKDL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 161 ENTDLIDVMYASADDNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTV 240
Cdd:COG0129  159 DIVDVFEAVGAYAAGKISDEELKEIERNACPGCGSCSGMFTANTMACLTEALGLSLPGSGTIPAVSAERRRLAREAGRRI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 241 VDIANRyyqhddeSVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGE 320
Cdd:COG0129  239 VELVEK-------DIKPRDILTREAFENAIAVDMALGGSTNTVLHLLAIAHEAGVDLTLDDFDRISRRTPHLCDLKPSGK 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 321 WEISDVHRAGGITGILGELDRAGKLHRDVHSVDYPSLEAKLADWDIMRDtcteeardffkaapghivspepwthettfes 400
Cdd:COG0129  312 YHMEDLHRAGGIPAVMKELLDAGLLHGDCLTVTGKTLAENLADADIDRD------------------------------- 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 401 ldtdrvNGAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALIIR 480
Cdd:COG0129  361 ------QDVIRPLDNPYSPTGGLAILRGNLAPDGAVVKTAGVDESMLVFEGPARVFDSEEEAVEAILGGKIKAGDVVVIR 434
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 481 YEGPKGGPGMQEMLYPTSFVKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVE 560
Cdd:COG0129  435 YEGPKGGPGMREMLSPTSALKGMGLGKSVALITDGRFSGGTRGLSIGHVSPEAAEGGPIALVEDGDIITIDIPARTLDLL 514
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 651883665 561 LSDEELAERRAKleagdgYVAHRDRQVSQALKAFAAFARSADKGATRDPE 610
Cdd:COG0129  515 VSDEELARRRAA------WKPPEPRVTSGVLAKYAKLVSSASKGAVTDPP 558
ILVD_EDD pfam00920
Dehydratase family;
33-605 0e+00

Dehydratase family;


Pssm-ID: 459998  Cd Length: 513  Bit Score: 759.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   33 KPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDDGIAMGHTGMLYSLPSREIIADTVEYQVNAHCA 112
Cdd:pfam00920   1 KPIIGIANSYSDLVPCHVHLRELAEAVKEGVREAGGVPAEFNTIGVCDGIAMGHEGMRYSLPSRELIADSIEEMLRAHPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  113 DALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTVlpdgtvkenTDLIDVMYASADDNMTDEDLLAYERTVCPT 192
Cdd:pfam00920  81 DGLVLIGGCDKIVPGMLMAAARLNIPAIFVSGGPMLPGGSG---------TDEFEAVGAYAAGKISEEELLEIERAACPG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  193 CGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTVVDIAnryyqhdDESVLPRSIATKHAFENAMTM 272
Cdd:pfam00920 152 CGSCGGMGTANTMACLAEALGLSLPGSATIPAVSAERLRLAREAGRRIVELV-------EEDIKPRDILTRKAFENAIVV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  273 DVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGEWEISDVHRAGGITGILGELDRAgKLHRDVHSV 352
Cdd:pfam00920 225 DMALGGSTNAVLHLLAIAREAGVDLTLDDFDRISRKVPLLADLKPSGKYLMEDFHRAGGVPAVLKELLDA-LLHGDVLTV 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  353 DYPSLEAKLADWDIMRDTCteeardffkaapghivspepwthettfesldtdrvngaIHDIDHPAVTEGGLAVLRGNLAP 432
Cdd:pfam00920 304 TGKTLGENLADAEVRDQDV--------------------------------------IRPLDNPISPTGGLAVLKGNLAP 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  433 DGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALIIRYEGPKGGPGMQEMLYPTSFVKGKGIGKEVALI 512
Cdd:pfam00920 346 DGAVVKTSAVDPEMLVFEGPARVFDSEEDALAAILDGKIKAGDVVVIRYEGPKGGPGMPEMLTPTSALLGAGLGKDVALI 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  513 TDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVELSDEELAERRAKLEAGDGYVAHRdrqvsQALK 592
Cdd:pfam00920 426 TDGRFSGASRGPSIGHVSPEAAVGGPIALVRDGDIIRIDIPNRTLDLLVSDEELAARRAAWKPPEPKVKGR-----GYLA 500
                         570
                  ....*....|...
gi 651883665  593 AFAAFARSADKGA 605
Cdd:pfam00920 501 KYAKLVSSASEGA 513
ilvD TIGR00110
dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth ...
23-608 0e+00

dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272910  Cd Length: 535  Bit Score: 727.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   23 AAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDDGIAMGHTGMLYSLPSREIIADT 102
Cdd:TIGR00110   1 ATGFTDEDFGKPFIGVANSYTTIVPGHMHLRDLAQAVKEGIEAAGGVAFEFNTIAVCDGIAMGHEGMKYSLPSREIIADS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  103 VEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTvlpdgTVKENTDLIDV---MYASADDNMTD 179
Cdd:TIGR00110  81 VETMVNAHRFDGLVCIPSCDKITPGMLMAAARLNIPSIFVTGGPMLPGHT-----KLGKKIDLVSAfeaVGEYAAGKISE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  180 EDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTVVDIANRYYqhddesvLPRS 259
Cdd:TIGR00110 156 EELEEIERSACPGCGSCSGMFTANTMACLTEALGLSLPGCSTMLATSAEKKRIAKNSGKRIVELVKKNI-------KPRD 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  260 IATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGEWEISDVHRAGGITGILGEL 339
Cdd:TIGR00110 229 ILTKEAFENAITVDMALGGSTNTVLHLLAIANEAGVDLSLDDFDRLSRKVPHIASLAPSGKYVMEDLHRAGGIPAVLKEL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  340 DRAGKLHRDVHSVDYPSLEAKLADWDIMRdtcteEARDffkaapghivspepwthettfesldtdrvngAIHDIDHPAVT 419
Cdd:TIGR00110 309 DREGLLHGDTLTVTGKTLGEILEQAPVIP-----EGQD-------------------------------VIRPLDNPVHQ 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  420 EGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALIIRYEGPKGGPGMQEMLYPTSF 499
Cdd:TIGR00110 353 EGGLAILKGNLAPNGAVVKIAGVDEDMTKFEGPAKVFESEEEALEAILGGKIKEGDVVVIRYEGPKGGPGMPEMLAPTSA 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  500 VKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVELSDEELAERRAKleagdgY 579
Cdd:TIGR00110 433 IKGMGLGKSVALITDGRFSGGTRGLCIGHVSPEAAEGGPIALVEDGDIIIIDIPNRKLDLQVSDEELAERRAS------W 506
                         570       580
                  ....*....|....*....|....*....
gi 651883665  580 VAHRDRQVSQALKAFAAFARSADKGATRD 608
Cdd:TIGR00110 507 KAPEPRYVKGYLAKYAKLVSSADEGAVLD 535
 
Name Accession Description Interval E-value
PRK12448 PRK12448
dihydroxy-acid dehydratase; Provisional
1-614 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237104  Cd Length: 615  Bit Score: 1158.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   1 MEMRSAKIMNGRIFAGARALYRAAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDD 80
Cdd:PRK12448   1 PKYRSRTTTHGRNMAGARALWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  81 GIAMGHTGMLYSLPSREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTVLPDGTVK 160
Cdd:PRK12448  81 GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKIIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 161 enTDLIDVMYASADDNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTV 240
Cdd:PRK12448 161 --LDLVDAMVAAADPSVSDEDVAQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSLLATHADRKQLFLEAGRRI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 241 VDIANRYYQHDDESVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPS-G 319
Cdd:PRK12448 239 VELAKRYYEQDDESVLPRSIATKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEVDFTMADIDRLSRKVPCLCKVAPNtQ 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 320 EWEISDVHRAGGITGILGELDRAGKLHRDVHSVDYPSLEAKLADWDIMRdTCTEEARDFFKAAPGHIVSPEPWTHETTFE 399
Cdd:PRK12448 319 KYHMEDVHRAGGIMGILGELDRAGLLHTDVPTVHGLTLGEALDQWDIMR-TQDEAVKEFFRAAPGGIRTTVAFSQDCRWD 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 400 SLDTDRVNGAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALII 479
Cdd:PRK12448 398 SLDTDRENGCIRSVEHAYSKDGGLAVLYGNIAEDGCIVKTAGVDESILKFTGPARVFESQDDAVEAILGGKVKAGDVVVI 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 480 RYEGPKGGPGMQEMLYPTSFVKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINV 559
Cdd:PRK12448 478 RYEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGAIGLVEDGDIIEIDIPNRSINL 557
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 651883665 560 ELSDEELAERRAKLEAGDGYV---AHRDRQVSQALKAFAAFARSADKGATRDPELINK 614
Cdd:PRK12448 558 LVSDEELAARRAAQEARGDKAwkpKNRERKVSFALKAYAALATSADKGAVRDKSKLGG 615
IlvD COG0129
Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, ...
1-610 0e+00

Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; Dihydroxyacid dehydratase/phosphogluconate dehydratase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439899  Cd Length: 558  Bit Score: 884.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   1 MEMRSAKIMNGRIFAGARALYRAAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDD 80
Cdd:COG0129    2 PKMRSDTVTKGRERAPARALLRATGLTDEDFGKPIIGIANSWNEIVPGHVHLDDLAEAVKEGIRAAGGVPFEFNTIAVSD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  81 GIAMGHTGMLYSLPSREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTvlpDGTVK 160
Cdd:COG0129   82 GIAMGHEGMRYSLPSRELIADSIETMVNAHCFDGLVCIPGCDKITPGMLMAAARLNIPSIFVYGGPMLPGKY---DGKDL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 161 ENTDLIDVMYASADDNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTV 240
Cdd:COG0129  159 DIVDVFEAVGAYAAGKISDEELKEIERNACPGCGSCSGMFTANTMACLTEALGLSLPGSGTIPAVSAERRRLAREAGRRI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 241 VDIANRyyqhddeSVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGE 320
Cdd:COG0129  239 VELVEK-------DIKPRDILTREAFENAIAVDMALGGSTNTVLHLLAIAHEAGVDLTLDDFDRISRRTPHLCDLKPSGK 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 321 WEISDVHRAGGITGILGELDRAGKLHRDVHSVDYPSLEAKLADWDIMRDtcteeardffkaapghivspepwthettfes 400
Cdd:COG0129  312 YHMEDLHRAGGIPAVMKELLDAGLLHGDCLTVTGKTLAENLADADIDRD------------------------------- 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 401 ldtdrvNGAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALIIR 480
Cdd:COG0129  361 ------QDVIRPLDNPYSPTGGLAILRGNLAPDGAVVKTAGVDESMLVFEGPARVFDSEEEAVEAILGGKIKAGDVVVIR 434
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 481 YEGPKGGPGMQEMLYPTSFVKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVE 560
Cdd:COG0129  435 YEGPKGGPGMREMLSPTSALKGMGLGKSVALITDGRFSGGTRGLSIGHVSPEAAEGGPIALVEDGDIITIDIPARTLDLL 514
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 651883665 561 LSDEELAERRAKleagdgYVAHRDRQVSQALKAFAAFARSADKGATRDPE 610
Cdd:COG0129  515 VSDEELARRRAA------WKPPEPRVTSGVLAKYAKLVSSASKGAVTDPP 558
ILVD_EDD pfam00920
Dehydratase family;
33-605 0e+00

Dehydratase family;


Pssm-ID: 459998  Cd Length: 513  Bit Score: 759.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   33 KPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDDGIAMGHTGMLYSLPSREIIADTVEYQVNAHCA 112
Cdd:pfam00920   1 KPIIGIANSYSDLVPCHVHLRELAEAVKEGVREAGGVPAEFNTIGVCDGIAMGHEGMRYSLPSRELIADSIEEMLRAHPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  113 DALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTVlpdgtvkenTDLIDVMYASADDNMTDEDLLAYERTVCPT 192
Cdd:pfam00920  81 DGLVLIGGCDKIVPGMLMAAARLNIPAIFVSGGPMLPGGSG---------TDEFEAVGAYAAGKISEEELLEIERAACPG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  193 CGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTVVDIAnryyqhdDESVLPRSIATKHAFENAMTM 272
Cdd:pfam00920 152 CGSCGGMGTANTMACLAEALGLSLPGSATIPAVSAERLRLAREAGRRIVELV-------EEDIKPRDILTRKAFENAIVV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  273 DVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGEWEISDVHRAGGITGILGELDRAgKLHRDVHSV 352
Cdd:pfam00920 225 DMALGGSTNAVLHLLAIAREAGVDLTLDDFDRISRKVPLLADLKPSGKYLMEDFHRAGGVPAVLKELLDA-LLHGDVLTV 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  353 DYPSLEAKLADWDIMRDTCteeardffkaapghivspepwthettfesldtdrvngaIHDIDHPAVTEGGLAVLRGNLAP 432
Cdd:pfam00920 304 TGKTLGENLADAEVRDQDV--------------------------------------IRPLDNPISPTGGLAVLKGNLAP 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  433 DGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALIIRYEGPKGGPGMQEMLYPTSFVKGKGIGKEVALI 512
Cdd:pfam00920 346 DGAVVKTSAVDPEMLVFEGPARVFDSEEDALAAILDGKIKAGDVVVIRYEGPKGGPGMPEMLTPTSALLGAGLGKDVALI 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  513 TDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVELSDEELAERRAKLEAGDGYVAHRdrqvsQALK 592
Cdd:pfam00920 426 TDGRFSGASRGPSIGHVSPEAAVGGPIALVRDGDIIRIDIPNRTLDLLVSDEELAARRAAWKPPEPKVKGR-----GYLA 500
                         570
                  ....*....|...
gi 651883665  593 AFAAFARSADKGA 605
Cdd:pfam00920 501 KYAKLVSSASEGA 513
ilvD TIGR00110
dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth ...
23-608 0e+00

dihydroxy-acid dehydratase; This protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272910  Cd Length: 535  Bit Score: 727.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   23 AAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDDGIAMGHTGMLYSLPSREIIADT 102
Cdd:TIGR00110   1 ATGFTDEDFGKPFIGVANSYTTIVPGHMHLRDLAQAVKEGIEAAGGVAFEFNTIAVCDGIAMGHEGMKYSLPSREIIADS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  103 VEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTTvlpdgTVKENTDLIDV---MYASADDNMTD 179
Cdd:TIGR00110  81 VETMVNAHRFDGLVCIPSCDKITPGMLMAAARLNIPSIFVTGGPMLPGHT-----KLGKKIDLVSAfeaVGEYAAGKISE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  180 EDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTVVDIANRYYqhddesvLPRS 259
Cdd:TIGR00110 156 EELEEIERSACPGCGSCSGMFTANTMACLTEALGLSLPGCSTMLATSAEKKRIAKNSGKRIVELVKKNI-------KPRD 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  260 IATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGEWEISDVHRAGGITGILGEL 339
Cdd:TIGR00110 229 ILTKEAFENAITVDMALGGSTNTVLHLLAIANEAGVDLSLDDFDRLSRKVPHIASLAPSGKYVMEDLHRAGGIPAVLKEL 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  340 DRAGKLHRDVHSVDYPSLEAKLADWDIMRdtcteEARDffkaapghivspepwthettfesldtdrvngAIHDIDHPAVT 419
Cdd:TIGR00110 309 DREGLLHGDTLTVTGKTLGEILEQAPVIP-----EGQD-------------------------------VIRPLDNPVHQ 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  420 EGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLKPGQALIIRYEGPKGGPGMQEMLYPTSF 499
Cdd:TIGR00110 353 EGGLAILKGNLAPNGAVVKIAGVDEDMTKFEGPAKVFESEEEALEAILGGKIKEGDVVVIRYEGPKGGPGMPEMLAPTSA 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  500 VKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVELSDEELAERRAKleagdgY 579
Cdd:TIGR00110 433 IKGMGLGKSVALITDGRFSGGTRGLCIGHVSPEAAEGGPIALVEDGDIIIIDIPNRKLDLQVSDEELAERRAS------W 506
                         570       580
                  ....*....|....*....|....*....
gi 651883665  580 VAHRDRQVSQALKAFAAFARSADKGATRD 608
Cdd:TIGR00110 507 KAPEPRYVKGYLAKYAKLVSSADEGAVLD 535
PRK00911 PRK00911
dihydroxy-acid dehydratase; Provisional
3-610 0e+00

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 234861  Cd Length: 552  Bit Score: 724.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   3 MRSAKIMNGRIFAGARALYRAAGVDGKDFGKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDDGI 82
Cdd:PRK00911   1 MRSDMITKGVERAPHRSMLRATGLTDEDFDKPFIGIANSWNEITPCNIHLNELADAVKEGVRAAGGVPFEFNTIGVSDGI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  83 AMGHTGMLYSLPSREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGTtvlPDGtvkEN 162
Cdd:PRK00911  81 AMGHEGMKYSLVSREVIADSIETVVNAHWFDGLVAIPGCDKNMPGMLMAAARLNVPSIFVYGGPILPGR---LKG---KD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 163 TDLIDV---MYASADDNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQT 239
Cdd:PRK00911 155 LTLVSVfeaVGAYAAGKISEEELKEIERNACPGAGSCGGMFTANTMACLIEALGMSLPGSGTIPAVDAERDELAREAGEA 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 240 VVDIANRyyqhddeSVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSG 319
Cdd:PRK00911 235 VVELLEK-------DIKPRDILTREAFENAIAVDMALGGSTNAVLHLLAIAHEAGVDLTLDDFNRISKRTPHLADLKPSG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 320 EWEISDVHRAGGITGILGELDRAGKLHRDVHSVDYPSLEAKLADWdimrdtcteeardffkaapghivspepwthettfE 399
Cdd:PRK00911 308 KYVMEDLHEAGGIPAVMKELLDAGLLHGDCLTVTGKTLAENLADA----------------------------------P 353
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 400 SLDTDrvngAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIwtFRGPALVVESQEQAIEVILNDTLKPGQALII 479
Cdd:PRK00911 354 DPDQD----VIRPLDNPISPTGGLAILKGNLAPEGAVVKIAGVKPEM--FTGPARVFDSEEEAMEAILAGKIKAGDVVVI 427
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 480 RYEGPKGGPGMQEMLYPTSFVKGKGIGKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINV 559
Cdd:PRK00911 428 RYEGPKGGPGMREMLAPTSAIVGAGLGDDVALITDGRFSGGTRGLCVGHVSPEAAVGGPIALVEDGDIITIDAPNRTLDV 507
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|.
gi 651883665 560 ELSDEELAERRAKleagdgYVAHRDRQVSQALKAFAAFARSADKGATRDPE 610
Cdd:PRK00911 508 LVSDEELARRRAA------WKPPEPKYKRGVLAKYAKLVSSASTGAVTDPP 552
PRK06131 PRK06131
dihydroxy-acid dehydratase; Validated
18-590 8.26e-114

dihydroxy-acid dehydratase; Validated


Pssm-ID: 235708  Cd Length: 571  Bit Score: 351.79  E-value: 8.26e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  18 RALYRAAGVDGKDF-GKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVddGIAMGH-TGMLYslps 95
Cdd:PRK06131  22 RSFMKNQGYPDELFdGRPIIGICNTWSDLNPCNAHFRQLAERVKRGVLEAGGFPVEFPVISL--GESFLRpTAMLY---- 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  96 REIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGT---TVLPDGTvkentdliDVMYAS 172
Cdd:PRK06131  96 RNLAAMDVEEMIRGYPIDGVVLLGGCDKTTPALLMGAASVDLPAIVLSGGPMLNGKhkgERLGSGT--------DVWKYW 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 173 AD---DNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTVVDIAnryyq 249
Cdd:PRK06131 168 EElraGEIDLEEFLEAEAGMARSAGTCNTMGTASTMACMAEALGMSLPGNAAIPAVDARRIRMAELTGRRIVEMV----- 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 250 HDDesVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGEWEISDVHRA 329
Cdd:PRK06131 243 HED--LKPSDILTREAFENAIRVNAAIGGSTNAVIHLIAIAGRAGVELDLDDWDRIGRDVPVLVNLQPSGEYLMEDFYYA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 330 GGITGILGELdrAGKLHRDVHSVDYPSLeakladWDIMRDtcteeardffkaAPGHivspepwthettfesldTDRVnga 409
Cdd:PRK06131 321 GGLPAVLREL--GELLHLDALTVNGKTL------GENLAG------------APVY-----------------NDDV--- 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 410 IHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDTLK--PGQALIIRYEGPKGG 487
Cdd:PRK06131 361 IRPLDNPLKPEGGIAVLRGNLAPDGAVIKPSAASPELLKHEGRAVVFEGYEDYKARIDDPDLDvdEDTVLVLRNAGPKGY 440
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 488 PGMQE---MLYPTSFVKgKGIgKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVELSDE 564
Cdd:PRK06131 441 PGMPEvgnMPIPKKLLR-QGV-KDMVRISDARMSGTAYGTVVLHVAPEAAAGGPLALVRTGDRIRLDVPARRLDLLVSDE 518
                        570       580       590
                 ....*....|....*....|....*....|.
gi 651883665 565 ELAERRAKLEA-----GDGYVAHRDRQVSQA 590
Cdd:PRK06131 519 ELARRRAAWPPpppraERGYQELYRDHVLQA 549
PRK13016 PRK13016
dihydroxy-acid dehydratase; Provisional
2-590 1.93e-104

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237271  Cd Length: 577  Bit Score: 327.84  E-value: 1.93e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665   2 EMRSAKIMNG---RIFaGARALYRAAGVDGKDF-GKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMA 77
Cdd:PRK13016   8 ELRSARWFGPddlRSF-GHRSRMMQMGYAPEDFdGKPVIAILNTWSDANPCHGHFRERVEDVKRGVLQAGGFPLELPALS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  78 VDDGIaMGHTGMLYslpsREIIADTVEYQVNAHCADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAGT---TVL 154
Cdd:PRK13016  87 LSENF-VKPTTMLY----RNLLAMETEELIRSHPVDGAVLMGGCDKTTPGLVMGAISMGLPMIYLPAGPMLRGNyrgKVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 155 PDGTvkentdliDVMYASAD---DNMTDEDLLAYERTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQ 231
Cdd:PRK13016 162 GSGS--------DAWKYWDErraGNITQAEWLEIEGGIARSYGTCMTMGTASTMTAIAEALGLTLPGASSIPAADANHQR 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 232 LFERAAQTVVDIANryyqhddESVLPRSIATKHAFENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPC 311
Cdd:PRK13016 234 MAALCGRRIVEMVW-------EDLTPSQILTKAAFENAITVAMATGCSTNAVIHLIAMARRAGVPLSLDDLDRCGRTVPV 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 312 ICKASPSGE-WEISDVHRAGGITGILGELdrAGKLHRDVHSVDYPSLEAKLADWDIMRDTcteeardffkaapghivspe 390
Cdd:PRK13016 307 IANIRPSGKtYLMEDFFYAGGLRALMKQL--GDKLHLDALTVTGKTLGDNLEGAKVYNDD-------------------- 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 391 pwthettfesldtdrvngAIHDIDHPAVTEGGLAVLRGNLAPDGCVVKTAGVPKEIWTFRGPALVVESQEQAIEVILNDT 470
Cdd:PRK13016 365 ------------------VIRPLDNPVYAEGSLAVLRGNLAPDGAVIKPAACDPKFLVHRGPALVFDSYPEMKAAIDDEN 426
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 471 L--KPGQALIIRYEGPKGGPGMQE--ML-YPTSFVKgKGIgKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENG 545
Cdd:PRK13016 427 LdvTPDHVMVLRNAGPQGGPGMPEwgMLpIPKKLLK-QGV-RDMVRISDARMSGTSYGACVLHVAPEAYVGGPLALVRTG 504
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 651883665 546 DMIVIDIPNRTINVELSDEELAERRAKLEA-----GDGYVAHRDRQVSQA 590
Cdd:PRK13016 505 DIIELDVPARRLHLLVSDEELARRRAAWQPperryERGYGWMFSQHVEQA 554
PRK13017 PRK13017
dihydroxy-acid dehydratase; Provisional
32-575 1.12e-100

dihydroxy-acid dehydratase; Provisional


Pssm-ID: 237272  Cd Length: 596  Bit Score: 318.44  E-value: 1.12e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665  32 GKPIVAIANSFDEFVPGHVHLNKVGRLVSEAVKQAGGIPREFNTMAVDDGiAMGHTGMLYslpsREIIADTVEYQVNAHC 111
Cdd:PRK13017  46 GKPIIGIAQTGSDLSPCNRHHLELAERVKEGIRDAGGIPMEFPVHPIQET-GKRPTAALD----RNLAYLGLVEILYGYP 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 112 ADALICISNCDKITPGMLMAALRLNIPTVFVSGGPMEAG---TTVLPDGTV--KENTDLidvmyasADDNMTDEDLLAYE 186
Cdd:PRK13017 121 LDGVVLTTGCDKTTPACLMAAATVDLPAIVLSGGPMLDGwheGERVGSGTViwKARELL-------AAGEIDYEEFMELV 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 187 RTVCPTCGSCAGMFTANSMNCLNEAIGLALPGNGTVLASHGYRKQLFERAAQTVVDIAnryyqHDDesVLPRSIATKHAF 266
Cdd:PRK13017 194 ASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRERGQMAYATGKRIVEMV-----WED--LKPSDILTREAF 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 267 ENAMTMDVAMGGSTNTVLHILAMAQSADVDFTLDDIERISHTVPCICKASPSGEWEISDVHRAGGITGILGELDRAGKLH 346
Cdd:PRK13017 267 ENAIVVNSAIGGSTNAPIHLIAIARHAGVELSLDDWQRVGEDVPLLVNLQPAGKYLGEDFHRAGGVPAVLAELLRAGLLH 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 347 RDVHSVDYPSLEAKLADwdimrdtcteeardffkaapghivspepwthettFESLDTDrvngAIHDIDHPAVTEGGLAVL 426
Cdd:PRK13017 347 GDALTVSGRTIGENIAG----------------------------------APAPDRD----VIRPYDAPLKERAGFLVL 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 427 RGNLApDGCVVKTAGV-----------PKEIWTFRGPALVVESQEQAIEVILNDTLKPGQ--ALIIRYEGPKGGPGMQE- 492
Cdd:PRK13017 389 RGNLF-DSAIMKTSVIseefrerylsePGDENAFEGRAVVFDGPEDYHARIDDPALDIDEhcILVIRGAGPVGYPGSAEv 467
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651883665 493 --MLYPTSFVKgKGIgKEVALITDGRYSGGSSGLSIGHVAPEAASGGPIALVENGDMIVIDIPNRTINVELSDEELAERR 570
Cdd:PRK13017 468 vnMQPPAALLK-RGI-RSLPCIGDGRQSGTSGSPSILNASPEAAVGGGLALLRTGDRIRIDLNKRRVDVLVSDEELARRR 545

                 ....*
gi 651883665 571 AKLEA 575
Cdd:PRK13017 546 AALKP 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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