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Conserved domains on  [gi|648396844|ref|WP_026088595|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Pseudomonadaceae]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 15841257)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355
SCOP:  4000333|3000001|3000086

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 96-205 2.35e-22

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


:

Pssm-ID: 465574  Cd Length: 114  Bit Score: 87.23  E-value: 2.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844   96 DTRERLLALIRCELQSIMGGTGEAmAVLVYEWRSLSEEGQAQVLALRDTYEQIWLAVLGEAREAGYFKG-DPFIQRRFLT 174
Cdd:pfam17932   3 SPVERLRALVRAHVRVHAERRDEA-AVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAAGEFRDlDPKLAALAIL 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 648396844  175 GALSWTNTWFRSQGPMTLDQLAEEALSLVCK 205
Cdd:pfam17932  82 GMLNWVYRWYRPDGPLSPEEIADQYADLLLR 112
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
29-75 1.10e-11

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.42  E-value: 1.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 648396844   29 LLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSV 75
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 96-205 2.35e-22

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 87.23  E-value: 2.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844   96 DTRERLLALIRCELQSIMGGTGEAmAVLVYEWRSLSEEGQAQVLALRDTYEQIWLAVLGEAREAGYFKG-DPFIQRRFLT 174
Cdd:pfam17932   3 SPVERLRALVRAHVRVHAERRDEA-AVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAAGEFRDlDPKLAALAIL 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 648396844  175 GALSWTNTWFRSQGPMTLDQLAEEALSLVCK 205
Cdd:pfam17932  82 GMLNWVYRWYRPDGPLSPEEIADQYADLLLR 112
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
21-177 2.92e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 69.93  E-value: 2.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  21 DPDSARGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEETIVYNTALMRAALAEAqDTRER 100
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE-DPRER 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 648396844 101 LLALIRCELQSIMggTGEAMAVLVYEWRSLSEEGQAQVLALRDTYEQIWLAVLGEAREAGyfKGDPFIQRRFLTGAL 177
Cdd:COG1309   82 LRALLRAYLEFLA--ENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLA--DVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
29-75 1.10e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.42  E-value: 1.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 648396844   29 LLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSV 75
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 28-106 8.41e-07

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 47.52  E-value: 8.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  28 KLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKE-----------EILRSVMEETIvyntalmraALAEAQD 96
Cdd:NF037937   3 KILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQglleylvtsffEGYLEILEEGF---------EELKNLS 73

                         90
                 ....*....|
gi 648396844  97 TRERLLALIR 106
Cdd:NF037937  74 AKECLKQLVR 83
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
26-78 2.31e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 46.05  E-value: 2.31e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 648396844  26 RGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEE 78
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
21-106 3.46e-06

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 45.70  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  21 DPDSARGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEETIVYNTALMRAALAEAQDTRER 100
Cdd:COG3226    5 RGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDA 84


                 ....*.
gi 648396844 101 LLALIR 106
Cdd:COG3226   85 AEALAD 90
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 26-106 1.14e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 38.57  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  26 RGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEET-----IVYNTALMRAALAEAQDTRER 100
Cdd:PRK09975  13 RQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQpplreLIQEHLTAGLEHDPLQQLREK 92


                 ....*.
gi 648396844 101 LLALIR 106
Cdd:PRK09975  93 FIAGLQ 98
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 26-126 1.43e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.45  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  26 RGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEET--------IVYNT-------ALMRAA 90
Cdd:PRK10668  13 RQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSeskigeleLEYQAkfpddplSVLREI 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 648396844  91 L-----AEAQDTRERLLALI---RCELQSIMGGTGEAMAVLVYE 126
Cdd:PRK10668  93 LiyileATVTDERRRLLMEIifhKCEFVGEMAVVQQAQRNLCLE 136
 
Name Accession Description Interval E-value
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 96-205 2.35e-22

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 87.23  E-value: 2.35e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844   96 DTRERLLALIRCELQSIMGGTGEAmAVLVYEWRSLSEEGQAQVLALRDTYEQIWLAVLGEAREAGYFKG-DPFIQRRFLT 174
Cdd:pfam17932   3 SPVERLRALVRAHVRVHAERRDEA-AVFLRELRSLSPEHRAEIRALRREYERLLRDLIEEGVAAGEFRDlDPKLAALAIL 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 648396844  175 GALSWTNTWFRSQGPMTLDQLAEEALSLVCK 205
Cdd:pfam17932  82 GMLNWVYRWYRPDGPLSPEEIADQYADLLLR 112
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
21-177 2.92e-15

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 69.93  E-value: 2.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  21 DPDSARGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEETIVYNTALMRAALAEAqDTRER 100
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE-DPRER 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 648396844 101 LLALIRCELQSIMggTGEAMAVLVYEWRSLSEEGQAQVLALRDTYEQIWLAVLGEAREAGyfKGDPFIQRRFLTGAL 177
Cdd:COG1309   82 LRALLRAYLEFLA--ENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLA--DVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
29-75 1.10e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.42  E-value: 1.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 648396844   29 LLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSV 75
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 28-106 8.41e-07

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 47.52  E-value: 8.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  28 KLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKE-----------EILRSVMEETIvyntalmraALAEAQD 96
Cdd:NF037937   3 KILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKQglleylvtsffEGYLEILEEGF---------EELKNLS 73

                         90
                 ....*....|
gi 648396844  97 TRERLLALIR 106
Cdd:NF037937  74 AKECLKQLVR 83
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
26-78 2.31e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 46.05  E-value: 2.31e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 648396844  26 RGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEE 78
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
21-106 3.46e-06

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 45.70  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  21 DPDSARGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEETIVYNTALMRAALAEAQDTRER 100
Cdd:COG3226    5 RGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDA 84


                 ....*.
gi 648396844 101 LLALIR 106
Cdd:COG3226   85 AEALAD 90
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 26-106 1.14e-03

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 38.57  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  26 RGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEET-----IVYNTALMRAALAEAQDTRER 100
Cdd:PRK09975  13 RQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQpplreLIQEHLTAGLEHDPLQQLREK 92


                 ....*.
gi 648396844 101 LLALIR 106
Cdd:PRK09975  93 FIAGLQ 98
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 26-126 1.43e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.45  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648396844  26 RGKLLQMAAHLFRSKGYERTTVRDLAAAIGIQSGSIFHHFKSKEEILRSVMEET--------IVYNT-------ALMRAA 90
Cdd:PRK10668  13 RQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSeskigeleLEYQAkfpddplSVLREI 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 648396844  91 L-----AEAQDTRERLLALI---RCELQSIMGGTGEAMAVLVYE 126
Cdd:PRK10668  93 LiyileATVTDERRRLLMEIifhKCEFVGEMAVVQQAQRNLCLE 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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