|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
5-242 |
3.54e-119 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 339.46 E-value: 3.54e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 5 IEKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEiskdgYSPEYLLSSNYLQDDPEGFTNFYHKRL-LLSDKKP 83
Cdd:PRK00481 3 IEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEE-----HRPEDVASPEGFARDPELVWKFYNERRrQLLDAKP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 84 NVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLRQCEACGSPIRPDIV 163
Cdd:PRK00481 78 NAAHRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPRCPKCGGILRPDVV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 164 LYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAEVVSALR 241
Cdd:PRK00481 158 LFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLpyEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELV 237
|
.
gi 648267835 242 D 242
Cdd:PRK00481 238 E 238
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
8-231 |
6.49e-107 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 307.76 E-value: 6.49e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 8 LKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEISKdgYSPEYLLSSNYLQDDPEGFTNFYHKRLLLSDKKPNVVH 87
Cdd:cd01411 1 LQHILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIYK--YSPEYLLSHDFLEREPEKFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 88 DWMAQLEKEGRsLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYekSYVIEQDLRQCEACGSPIRPDIVLYGE 167
Cdd:cd01411 79 QKMAELEKMGL-KAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTV--DWEEYLKSPYHAKCGGVIRPDIVLYEE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648267835 168 MLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGLISNFQ-GKHLVIINKAETPYDTQADLVIHD 231
Cdd:cd01411 156 MLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQaGANLIAINKEPTQLDSPATLVIKD 220
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
1-242 |
2.28e-101 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 294.38 E-value: 2.28e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 1 MDAnIEKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDeiskdGYSPEYLLSSNYLQDDPEGFTNFYHKRL-LLS 79
Cdd:COG0846 1 MTK-IERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWE-----KYDPEEVASPEAFRRDPELVWAFYNERRrLLR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 80 DKKPNVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLRQ----CEACG 155
Cdd:COG0846 75 DAEPNAAHRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGElpprCPKCG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 156 SPIRPDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGLISNFQ--GKHLVIINKAETPYDTQADLVIHDDM 233
Cdd:COG0846 155 GLLRPDVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKraGAPLVEINPEPTPLDSLADLVIRGDA 234
|
....*....
gi 648267835 234 AEVVSALRD 242
Cdd:COG0846 235 GEVLPALVE 243
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
23-198 |
4.14e-75 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 225.59 E-value: 4.14e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 23 GAGVSVASGIPDFRSMGGLFDEISKDG-YSPEYLLSSNYLQDDPEGFTNFYHkRLLLSDKKPNVVHDWMAQLEKEGRSLG 101
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEElASPEAFFSNPELVWDPEPFYNIAR-ELLPGEAQPNPAHYFIAKLEDKGKLLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 102 VITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIE----QDLRQCEACGSPIRPDIVLYGEMLNQgTVMNA 177
Cdd:pfam02146 80 LITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYErirpEKVPHCPQCGGLLKPDIVFFGENLPD-KFHRA 158
|
170 180
....*....|....*....|.
gi 648267835 178 ISKISEADTLIVLGSSLIVQP 198
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
6-240 |
2.12e-70 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 215.90 E-value: 2.12e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 6 EKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEiskdgYSPEYLLSSNYLQDDPEGFTNFYHKRL-LLSDKKPN 84
Cdd:NF040867 1 EKAAELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRR-----YDPEELATIEAFERDPKLVWEFYRWRMeKLFDAKPN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 85 VVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYE-----KSYVIEQDLRQCEACGSPIR 159
Cdd:NF040867 76 PAHYALAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDleevlRKIDKGELPPRCPECGGLLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 160 PDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAEVV 237
Cdd:NF040867 156 PDVVLFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLpyIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVL 235
|
...
gi 648267835 238 SAL 240
Cdd:NF040867 236 PKL 238
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
5-242 |
3.54e-119 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 339.46 E-value: 3.54e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 5 IEKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEiskdgYSPEYLLSSNYLQDDPEGFTNFYHKRL-LLSDKKP 83
Cdd:PRK00481 3 IEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEE-----HRPEDVASPEGFARDPELVWKFYNERRrQLLDAKP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 84 NVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLRQCEACGSPIRPDIV 163
Cdd:PRK00481 78 NAAHRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPRCPKCGGILRPDVV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 164 LYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAEVVSALR 241
Cdd:PRK00481 158 LFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLpyEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELV 237
|
.
gi 648267835 242 D 242
Cdd:PRK00481 238 E 238
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
8-231 |
6.49e-107 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 307.76 E-value: 6.49e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 8 LKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEISKdgYSPEYLLSSNYLQDDPEGFTNFYHKRLLLSDKKPNVVH 87
Cdd:cd01411 1 LQHILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIYK--YSPEYLLSHDFLEREPEKFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 88 DWMAQLEKEGRsLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYekSYVIEQDLRQCEACGSPIRPDIVLYGE 167
Cdd:cd01411 79 QKMAELEKMGL-KAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTV--DWEEYLKSPYHAKCGGVIRPDIVLYEE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648267835 168 MLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGLISNFQ-GKHLVIINKAETPYDTQADLVIHD 231
Cdd:cd01411 156 MLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQaGANLIAINKEPTQLDSPATLVIKD 220
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
1-242 |
2.28e-101 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 294.38 E-value: 2.28e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 1 MDAnIEKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDeiskdGYSPEYLLSSNYLQDDPEGFTNFYHKRL-LLS 79
Cdd:COG0846 1 MTK-IERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWE-----KYDPEEVASPEAFRRDPELVWAFYNERRrLLR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 80 DKKPNVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLRQ----CEACG 155
Cdd:COG0846 75 DAEPNAAHRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGElpprCPKCG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 156 SPIRPDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGLISNFQ--GKHLVIINKAETPYDTQADLVIHDDM 233
Cdd:COG0846 155 GLLRPDVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKraGAPLVEINPEPTPLDSLADLVIRGDA 234
|
....*....
gi 648267835 234 AEVVSALRD 242
Cdd:COG0846 235 GEVLPALVE 243
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
16-232 |
2.82e-93 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 272.91 E-value: 2.82e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRSMGGLFDEISKDgyspEYLLSSNYLQDDPEGFTNFYHKRLLLSDKKPNVVHDWMAQLEK 95
Cdd:cd01407 1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDPE----ELAFSPEAFRRDPELFWGFYRERRYPLNAQPNPAHRALAELER 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 96 EGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIE----QDLRQCEACGSPIRPDIVLYGEMLNQ 171
Cdd:cd01407 77 KGKLKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQAdidrEEVPRCPKCGGLLRPDVVFFGESLPE 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648267835 172 GtVMNAISKISEADTLIVLGSSLIVQPAAGLIS--NFQGKHLVIINKAETPYDTQADLVIHDD 232
Cdd:cd01407 157 E-LDEAAEALAKADLLLVIGTSLQVYPAAGLPLyaPERGAPVVIINLEPTPADRKADLVILGD 218
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
12-232 |
8.06e-83 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 246.51 E-value: 8.06e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 12 VDDSKKITFFTGAGVSVASGIPDFRSMGGLFDeiskdGYSPEYLLSSNYLQDDPEGFTNFYHKRLL-LSDKKPNVVHDWM 90
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWK-----KYDPEEVASIDYFYRNPEEFWRFYKEIILgLLEAQPNKAHYFL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 91 AQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEY---EKSYVIEQDLRQCEACGSPIRPDIVLYGE 167
Cdd:cd01413 76 AELEKQGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYdleEVKYAKKHEVPRCPKCGGIIRPDVVLFGE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 648267835 168 MLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDD 232
Cdd:cd01413 156 PLPQALLREAIEAAKEADLFIVLGSSLVVYPANLLplIAKENGAKLVIVNADETPFDYIADLVIQDK 222
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
16-232 |
1.60e-78 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 235.70 E-value: 1.60e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRSMG-GLFDEISKDgyspEYLLSSNYLQDDPEGFTNFYHKRLLLS-DKKPNVVHDWMAQL 93
Cdd:cd00296 1 KRVVVFTGAGISTESGIPDFRGLGtGLWTRLDPE----ELAFSPEAFRRDPELFWLFYKERRYTPlDAKPNPAHRALAEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 94 EKEGRSLGVITQNIDGLDADAGSQ--NIDELHGTLNRFYCISCHKEYEKSYVIEQ-DLRQCEACGSPIRPDIVLYGEMLN 170
Cdd:cd00296 77 ERKGKLKRIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDEVLEReKPPRCPKCGGLLRPDVVDFGEALP 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 648267835 171 QGTVMNAISKISEADTLIVLGSSLIVQPAAGLIS--NFQGKHLVIINKAETPYDT--QADLVIHDD 232
Cdd:cd00296 157 KEWFDRALEALLEADLVLVIGTSLTVYPAARLLLraPERGAPVVIINREPTPADAlkKADLVILGD 222
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
23-198 |
4.14e-75 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 225.59 E-value: 4.14e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 23 GAGVSVASGIPDFRSMGGLFDEISKDG-YSPEYLLSSNYLQDDPEGFTNFYHkRLLLSDKKPNVVHDWMAQLEKEGRSLG 101
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEElASPEAFFSNPELVWDPEPFYNIAR-ELLPGEAQPNPAHYFIAKLEDKGKLLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 102 VITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIE----QDLRQCEACGSPIRPDIVLYGEMLNQgTVMNA 177
Cdd:pfam02146 80 LITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYErirpEKVPHCPQCGGLLKPDIVFFGENLPD-KFHRA 158
|
170 180
....*....|....*....|.
gi 648267835 178 ISKISEADTLIVLGSSLIVQP 198
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
6-240 |
2.12e-70 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 215.90 E-value: 2.12e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 6 EKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEiskdgYSPEYLLSSNYLQDDPEGFTNFYHKRL-LLSDKKPN 84
Cdd:NF040867 1 EKAAELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRR-----YDPEELATIEAFERDPKLVWEFYRWRMeKLFDAKPN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 85 VVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYE-----KSYVIEQDLRQCEACGSPIR 159
Cdd:NF040867 76 PAHYALAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDleevlRKIDKGELPPRCPECGGLLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 160 PDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAEVV 237
Cdd:NF040867 156 PDVVLFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLpyIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVL 235
|
...
gi 648267835 238 SAL 240
Cdd:NF040867 236 PKL 238
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
5-235 |
4.28e-61 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 192.35 E-value: 4.28e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 5 IEKLKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEIskdgysPEYLLSSNYLQDDPEGFTNFYHKRLL-LSDKKP 83
Cdd:PRK14138 1 MKEFLELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKY------PQNVFDIDFFYSHPEEFYRFAKEGIFpMLEAKP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 84 NVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQ----DLRQCEACGSPIR 159
Cdd:PRK14138 75 NLAHVLLAKLEEKGLIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKleksDVPRCDDCSGLIR 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648267835 160 PDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAE 235
Cdd:PRK14138 155 PNIVFFGEALPQDALREAIRLSSKASLMIVMGSSLVVYPAAELplITVRSGGKLVIVNLGETPLDDIATLKYNMDVVE 232
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
16-240 |
1.55e-58 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 184.72 E-value: 1.55e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRSMGGLFDeiskdGYSPEYLLSSNYLQDDPEGFTNFYH-KRLLLSDKKPNVVHDWMAQLE 94
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWA-----RFDPEELATPEAFARDPELVWEFYNwRRRKALRAQPNPAHLALAELE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 95 KEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVI-EQDLRQCEACGSPIRPDIVLYGEMLNQGt 173
Cdd:cd01412 76 RRLPNVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENNEEIpEEELPRCPKCGGLLRPGVVWFGESLPLA- 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 648267835 174 VMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAEVVSAL 240
Cdd:cd01412 155 LLEAVEALAKADLFLVIGTSGVVYPAAGLpeEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPAL 223
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
16-232 |
1.22e-50 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 164.01 E-value: 1.22e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRSMGGLFDEISKDGYSPEYLLSsnylqddpegftnfyhkrllLSDKKPNVVHDWMAQLEK 95
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLPEDKGRRRFSWR--------------------FRRAEPTLTHMALVELER 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 96 EGRSLGVITQNIDGLDADAG--SQNIDELHGTLNRFYCISCHKEYEKSYVIE-----QDLRQCEACGSPIRPDIVLYGEM 168
Cdd:cd01410 61 AGLLKFVISQNVDGLHLRSGlpREKLSELHGNMFIEVCKSCGPEYVRDDVVEtrgdkETGRRCHACGGILKDTIVDFGER 140
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 648267835 169 LNQGTVMNAISKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDD 232
Cdd:cd01410 141 LPPENWMGAAAAACRADLFLCLGTSLQVTPAANLplKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
16-240 |
3.90e-45 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 150.86 E-value: 3.90e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRSMG-GLFDEISKDGYS-PEYLLSSNYLQDDPEGFTNFyHKRLLLSDKKPNVVHDWMAQL 93
Cdd:cd01408 1 KKIVVLVGAGISTSAGIPDFRSPGtGLYANLARYNLPyPEAMFDISYFRKNPRPFYAL-AKELYPGQFKPSVAHYFIKLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 94 EKEGRSLGVITQNIDGLDADAGSQN--IDELHGTLNRFYCISCHKEYEKSYVIEQDLRQ----CEACGSPIRPDIVLYGE 167
Cdd:cd01408 80 EDKGLLLRNYTQNIDTLERVAGVPDdrIIEAHGSFATAHCIKCKHKYPGDWMREDIFNQevpkCPRCGGLVKPDIVFFGE 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 648267835 168 MLNQG--TVMNAIskISEADTLIVLGSSLIVQPAAGLISnFQGKHL--VIINKAETPY--DTQADLVIHDDMAEVVSAL 240
Cdd:cd01408 160 SLPSRffSHMEED--KEEADLLIVIGTSLKVAPFASLPS-RVPSEVprVLINREPVGHlgKRPFDVALLGDCDDGVREL 235
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
8-229 |
5.05e-37 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 130.88 E-value: 5.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 8 LKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDEISKDGYSPEYLLSSNYLQDdpegftnfYHKRLLL-----SDKK 82
Cdd:cd01409 1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSRTFRPMTHQEFMRSPAARQR--------YWARSFVgwprfSAAQ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 83 PNVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKS-----------YVIEQDLRQ- 150
Cdd:cd01409 73 PNAAHRALAALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAelqdrlealnpGFAEQAAGQa 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 151 -------------------CEACGSPIRPDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGLI--SNFQGK 209
Cdd:cd01409 153 pdgdvdledeqvagfrvpeCERCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVlaAAEAGL 232
|
250 260
....*....|....*....|
gi 648267835 210 HLVIINKAETPYDTQADLVI 229
Cdd:cd01409 233 PIAIVNIGPTRADHLATLKV 252
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
16-242 |
5.22e-36 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 127.63 E-value: 5.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRSMGGLFDEIS-KDGYSPEYLLSSnylqddPEGFTNFYHKR---LLLSDKKPNVVHDWMA 91
Cdd:PTZ00408 5 RCITILTGAGISAESGISTFRDGNGLWENHRvEDVATPDAFLRN------PALVQRFYNERrraLLSSSVKPNKAHFALA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 92 QLEKE--GRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLRQCEACG--SPIRPDIVLYGE 167
Cdd:PTZ00408 79 KLEREyrGGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVVHGSSRCKCCGcvGTLRPHIVWFGE 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648267835 168 MlnqGTVMNAI-SKISEADTLIVLGSSLIVQPAAGL--ISNFQGKHLVIINKAETPYDTQADLVIHDDMAEVVSALRD 242
Cdd:PTZ00408 159 M---PLYMDEIeSVMSKTDLFVAVGTSGNVYPAAGFvgRAQFYGATTLELNLEEGTNYSQFDESIYGKASVIVPAWVD 233
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
13-202 |
2.37e-29 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 112.65 E-value: 2.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 13 DDSKKITFFTGAGVSVASGIPDFRS-MGGLFDEISKDGY-SPEYLLSSNYLQDDPEGFTNFYHKRLLLSDK-KPNVVHDW 89
Cdd:PTZ00410 27 NNVTKILVMVGAGISVAAGIPDFRSpHTGIYAKLGKYNLnSPTDAFSLTLLREKPEVFYSIAREMDLWPGHfQPTAVHHF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 90 MAQLEKEGRSLGVITQNIDGLDADAG--SQNIDELHGTLNRFYCISCHKEYEksyvIEQDLRQ--------CEACGSPIR 159
Cdd:PTZ00410 107 IRLLADEGRLLRCCTQNIDGLERAAGvpPSLLVEAHGSFSAASCIECHTPYD----IEQAYLEarsgkvphCSTCGGIVK 182
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 648267835 160 PDIVLYGEMLNQGtVMNAISKISEADTLIVLGSSLIVQPAAGL 202
Cdd:PTZ00410 183 PDVVFFGENLPDA-FFNVHHDIPEAELLLIIGTSLQVHPFALL 224
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
8-240 |
1.78e-26 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 103.60 E-value: 1.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 8 LKEIVDDSKKITFFTGAGVSVASGIPDFRSMGGLFDE---ISKDGYSPEYLLSSNYLQDDPEGFTNFYHKRlllsdkkPN 84
Cdd:PRK05333 12 LQDFVERHPRLFVLTGAGISTDSGIPDYRDRNGQWKRsppITYQAFMGSDAARRRYWARSMVGWPVFGRAQ-------PN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 85 VVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLRQ-------------- 150
Cdd:PRK05333 85 AAHHALARLGAAGRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHPRAEIQHVLEAAnpewlaleaapapd 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 151 -----------------CEACGSPIRPDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIV-------QPAAGlisnf 206
Cdd:PRK05333 165 gdadlewaafdhfrvpaCPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVysgyrfcVWAAQ----- 239
|
250 260 270
....*....|....*....|....*....|....
gi 648267835 207 QGKHLVIINKAETPYDTQADLVIHDDMAEVVSAL 240
Cdd:PRK05333 240 QGKPIAALNLGRTRADPLLTLKVEASCAQALAAL 273
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
5-219 |
1.17e-25 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 101.15 E-value: 1.17e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 5 IEKLKEIVDDSKKITFFTGAGVSVASGIPDFRSmgglfdeiSKDGYSPEYllssnylqdDPE------GFTNFYHK---- 74
Cdd:PTZ00409 18 LEDLADMIRKCKYVVALTGSGTSAESNIPSFRG--------PSSSIWSKY---------DPKiygtiwGFWKYPEKiwev 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 75 -RLLLSDKKP--NVVHDWMAQLEKEGRSLGVITQNIDGLDADAGSQNIDELHGTLNRFYCISCHKEYEKSYVIEQDLR-- 149
Cdd:PTZ00409 81 iRDISSDYEIelNPGHVALSTLESLGYLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQLNKIMLQKTShf 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648267835 150 ------QCeACGSPIRPDIVLYGEMLNQGTVMNAISKISEADTLIVLGSSLIVQPAAGLI--SNFQGKHLVIINKAET 219
Cdd:PTZ00409 161 mhqlppEC-PCGGIFKPNVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCyrAHRKKKKIVEVNISKT 237
|
|
| SIR2-like |
cd01406 |
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ... |
16-108 |
2.44e-04 |
|
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Pssm-ID: 238697 [Multi-domain] Cd Length: 242 Bit Score: 41.23 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648267835 16 KKITFFTGAGVSVASGIPDFRsmgGLFDEISK------DGYSPEYLLSSNYLQ----DDPEGFTNFYHKRLLL-----SD 80
Cdd:cd01406 1 GRVVIFVGAGVSVSSGLPDWK---TLLDEIASelgleiDGYSVEAKDENDYLElaelLEKEFGTIGIKINAVLeektrPD 77
|
90 100
....*....|....*....|....*....
gi 648267835 81 KKPNVVHDWMAQLEKEG-RSLGVITQNID 108
Cdd:cd01406 78 FEPSPLHELLLRLFINNeGDVIIITTNYD 106
|
|
| |
