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Conserved domains on  [gi|648218141|ref|WP_025999290|]
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MULTISPECIES: HNH endonuclease [Klebsiella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
170-278 3.57e-18

Predicted restriction endonuclease, HNH family [Defense mechanisms];


:

Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 78.50  E-value: 3.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648218141 170 SEKAKPKKAAIEVKnglSYPRSKSVSKNALNKADYKCEINCDHPTFRRRNSPLNYTEPHHIVPMSKQDyfENSLDVEENI 249
Cdd:COG3183    6 KGFTEGAKKEVTHK---RYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLSEIG--EGGVDPIEDL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 648218141 250 ISLCCNCHKQIHLGKGFE--NMLRKIYAERK 278
Cdd:COG3183   81 VPLCPNCHRMLHRGRPPLsiEELKKLLKRRK 111
 
Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
170-278 3.57e-18

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 78.50  E-value: 3.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648218141 170 SEKAKPKKAAIEVKnglSYPRSKSVSKNALNKADYKCEINCDHPTFRRRNSPLNYTEPHHIVPMSKQDyfENSLDVEENI 249
Cdd:COG3183    6 KGFTEGAKKEVTHK---RYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLSEIG--EGGVDPIEDL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 648218141 250 ISLCCNCHKQIHLGKGFE--NMLRKIYAERK 278
Cdd:COG3183   81 VPLCPNCHRMLHRGRPPLsiEELKKLLKRRK 111
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 196-261 5.83e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 5.83e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 648218141 196 KNALNKADYKCEInCDhptfrrRNSPLNYTEPHHIVPMSKqdyfeNSLDVEENIISLCCNCHKQIH 261
Cdd:cd00085    4 RLVLLARDGLCPY-CG------KPGGTEGLEVDHIIPLSD-----GGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 228-261 1.20e-03

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 36.18  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 648218141  228 HHIVPMSKqdyfENSLDvEENIISLCCNCHKQIH 261
Cdd:pfam01844  17 DHIIPLSD----GGADD-IENLILLCPSCHNKKH 45
HNHc smart00507
HNH nucleases;
196-257 9.70e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.59  E-value: 9.70e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648218141   196 KNALNKADYKCEINCDHPTFrrrnsplnYTEPHHIVPMSkqDYFENSLDveeNIISLCCNCH 257
Cdd:smart00507   3 RRLLLHRDGVCAYCGKPASE--------GLEVDHIIPLS--DGGNDDLD---NLVLLCPKCH 51
 
Name Accession Description Interval E-value
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
170-278 3.57e-18

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 78.50  E-value: 3.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648218141 170 SEKAKPKKAAIEVKnglSYPRSKSVSKNALNKADYKCEINCDHPTFRRRNSPLNYTEPHHIVPMSKQDyfENSLDVEENI 249
Cdd:COG3183    6 KGFTEGAKKEVTHK---RYERNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGEGYIEVHHLIPLSEIG--EGGVDPIEDL 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 648218141 250 ISLCCNCHKQIHLGKGFE--NMLRKIYAERK 278
Cdd:COG3183   81 VPLCPNCHRMLHRGRPPLsiEELKKLLKRRK 111
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 196-261 5.83e-04

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 5.83e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 648218141 196 KNALNKADYKCEInCDhptfrrRNSPLNYTEPHHIVPMSKqdyfeNSLDVEENIISLCCNCHKQIH 261
Cdd:cd00085    4 RLVLLARDGLCPY-CG------KPGGTEGLEVDHIIPLSD-----GGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 228-261 1.20e-03

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 36.18  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 648218141  228 HHIVPMSKqdyfENSLDvEENIISLCCNCHKQIH 261
Cdd:pfam01844  17 DHIIPLSD----GGADD-IENLILLCPSCHNKKH 45
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
188-260 4.81e-03

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 34.96  E-value: 4.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648218141 188 YPRSKSVSKNALNKADYKCEInCdhptfrRRNSPLNYTEPHHIVPMSKqdyfeNSLDVEENIISLCCNCHKQI 260
Cdd:COG1403    4 GREWPALRRAVLKRDNGRCQY-C------GRPFSGDALEVDHIIPRSR-----GGTDTWENLVLLCRRCNRRK 64
HNHc smart00507
HNH nucleases;
196-257 9.70e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 33.59  E-value: 9.70e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648218141   196 KNALNKADYKCEINCDHPTFrrrnsplnYTEPHHIVPMSkqDYFENSLDveeNIISLCCNCH 257
Cdd:smart00507   3 RRLLLHRDGVCAYCGKPASE--------GLEVDHIIPLS--DGGNDDLD---NLVLLCPKCH 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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