|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
47-368 |
3.07e-83 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 256.79 E-value: 3.07e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 47 TVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLAD 126
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 127 LNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFT 206
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGTPLFT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 207 LARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASV 286
Cdd:COG0845 162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 287 -AAPAEHSVVLPWSALSKVGEQPAVWLLDQQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQP 365
Cdd:COG0845 242 vLGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKVRVVEA 321
|
...
gi 648202696 366 PQP 368
Cdd:COG0845 322 AAP 324
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
43-362 |
1.38e-62 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 203.32 E-value: 1.38e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 43 VLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQS 122
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 123 KLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATV 202
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 203 PIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVV 282
Cdd:TIGR01730 161 TLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 283 NASVAAPAEHSVVL-PWSALSKVGEQPAVWLLDQQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVE 361
Cdd:TIGR01730 241 RVTISLKVRSSAIVvPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRDGAKVK 320
|
.
gi 648202696 362 V 362
Cdd:TIGR01730 321 V 321
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
16-375 |
2.63e-21 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 94.40 E-value: 2.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 16 RMALPAILCASLLVGCGaEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQ----ADQSFRVGGKIVERLVDVGDHVA 91
Cdd:PRK09859 6 KLLIPLLFCGAMLTACD-DKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVpyevAEIRPQVGGIIIKRNFIEGDKVN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 92 AGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANAR 171
Cdd:PRK09859 85 QGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQAT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 172 DLLSYTELRASDAGV-----------ITARQAEVGQVVQATVPIFTLARDGERDaVFNVYESLFS---HDVDGQR-ITVS 236
Cdd:PRK09859 165 INLQYANVTSPITGVsgkssvtvgalVTANQADSLVTVQRLDPIYVDLTQSVQD-FLRMKEEVASgqiKQVQGSTpVQLN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 237 LLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVL-PWSALSKVGEQPAVWL-LD 314
Cdd:PRK09859 244 LENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLvPQEGVTHNAQGKATALiLD 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648202696 315 QQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPTQSTASR 375
Cdd:PRK09859 324 KDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESK 384
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
51-200 |
1.24e-16 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 79.77 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 51 AEFASATSITGDIQARVQADQ-SFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNY 129
Cdd:pfam00529 2 APLTKGVEAPGRVVVSGNAKAvQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAEL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648202696 130 QRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQA 200
Cdd:pfam00529 82 DRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQ 152
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
47-368 |
3.07e-83 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 256.79 E-value: 3.07e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 47 TVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLAD 126
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 127 LNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFT 206
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGTPLFT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 207 LARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASV 286
Cdd:COG0845 162 IADLDPLEVEFDVPESDLARLKVGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLRPGMFVRVRI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 287 -AAPAEHSVVLPWSALSKVGEQPAVWLLDQQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQP 365
Cdd:COG0845 242 vLGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLRDGAKVRVVEA 321
|
...
gi 648202696 366 PQP 368
Cdd:COG0845 322 AAP 324
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
43-362 |
1.38e-62 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 203.32 E-value: 1.38e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 43 VLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQS 122
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 123 KLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQATV 202
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 203 PIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVV 282
Cdd:TIGR01730 161 TLATIVDLDPLEADFSVPERDLPQLRRGQTLTVELDALPGEEFKGKLRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 283 NASVAAPAEHSVVL-PWSALSKVGEQPAVWLLDQQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVE 361
Cdd:TIGR01730 241 RVTISLKVRSSAIVvPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAGVVKLRDGAKVK 320
|
.
gi 648202696 362 V 362
Cdd:TIGR01730 321 V 321
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
64-286 |
1.73e-30 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 119.00 E-value: 1.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 64 QARVQADQ---SFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVEN---------------------------AQA 113
Cdd:COG1566 38 DGRVEARVvtvAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQaeaqlaaaeaqlarleaelgaeaeiaaAEA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 114 AVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQ---------------------------AQ 166
Cdd:COG1566 118 QLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAAQaqlaqaqaglreeeelaaaqaqvaqaeAA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 167 LANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTAS 246
Cdd:COG1566 198 LAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQPLLTIVPLDDLWVEAYVPETDLGRVKPGQPVEVRVDAYPDRVFE 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 648202696 247 GKVREITPTVDERSG----------TLKVKVGLD-SVPAEMSLGSVVNASV 286
Cdd:COG1566 278 GKVTSISPGAGFTSPpknatgnvvqRYPVRIRLDnPDPEPLRPGMSATVEI 328
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
16-375 |
2.63e-21 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 94.40 E-value: 2.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 16 RMALPAILCASLLVGCGaEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQ----ADQSFRVGGKIVERLVDVGDHVA 91
Cdd:PRK09859 6 KLLIPLLFCGAMLTACD-DKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVpyevAEIRPQVGGIIIKRNFIEGDKVN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 92 AGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANAR 171
Cdd:PRK09859 85 QGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQAT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 172 DLLSYTELRASDAGV-----------ITARQAEVGQVVQATVPIFTLARDGERDaVFNVYESLFS---HDVDGQR-ITVS 236
Cdd:PRK09859 165 INLQYANVTSPITGVsgkssvtvgalVTANQADSLVTVQRLDPIYVDLTQSVQD-FLRMKEEVASgqiKQVQGSTpVQLN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 237 LLGKPEVTASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAEHSVVL-PWSALSKVGEQPAVWL-LD 314
Cdd:PRK09859 244 LENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLvPQEGVTHNAQGKATALiLD 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648202696 315 QQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPTQSTASR 375
Cdd:PRK09859 324 KDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESK 384
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
72-208 |
1.47e-20 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 91.18 E-value: 1.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 72 SFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKL--------------------------A 125
Cdd:PRK03598 47 GFRVGGRLASLAVDEGDAVKAGQVLGELDAAPYENALMQAKANVSVAQAQLDLmlagyrdeeiaqaraavkqaqaaydyA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 126 DLNYQRQKALLPKGYTSQSEYD-------QALASVRSAQ-------------------SSLKAAQAQLANARDLLSYTEL 179
Cdd:PRK03598 127 QNFYNRQQGLWKSRTISANDLEnarssrdQAQATLKSAQdklsqyregnrpqdiaqakASLAQAQAALAQAELNLQDTEL 206
|
170 180
....*....|....*....|....*....
gi 648202696 180 RASDAGVITARQAEVGQVVQATVPIFTLA 208
Cdd:PRK03598 207 IAPSDGTILTRAVEPGTMLNAGSTVFTLS 235
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
74-369 |
1.43e-19 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 89.46 E-value: 1.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 74 RVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASV 153
Cdd:PRK11556 93 RVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTNLVSRQELDAQQALV 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 154 RSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQA--TVPIFTLARDGERDAVFNVYES----LFSHD 227
Cdd:PRK11556 173 SETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSgdTTGIVVITQTHPIDLVFTLPESdiatVVQAQ 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 228 VDGQRITVSLLGKPEVT--ASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASV-AAPAEHSVVLPWSALSKV 304
Cdd:PRK11556 253 KAGKPLVVEAWDRTNSKklSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNARMlVDTLQNAVVIPTAALQMG 332
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648202696 305 GEQPAVWLLDQQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVAQPPQPT 369
Cdd:PRK11556 333 NEGHFVWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVEPQSAT 397
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
51-200 |
1.24e-16 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 79.77 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 51 AEFASATSITGDIQARVQADQ-SFRVGGKIVERLVDVGDHVAAGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNY 129
Cdd:pfam00529 2 APLTKGVEAPGRVVVSGNAKAvQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAEL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 648202696 130 QRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQA 200
Cdd:pfam00529 82 DRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQ 152
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
17-383 |
4.19e-16 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 78.99 E-value: 4.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 17 MALPAILCASL-LVGCG---AEPPAEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVAA 92
Cdd:PRK15030 10 LAVVLMLSGSLaLTGCDdkqAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 93 GQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANARD 172
Cdd:PRK15030 90 GVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 173 LLSYTELRASDAGVITARQAEVGQVVQ-------ATV----PIFTLARDGERDaVFNVYESLFSHDVDGQ--RITVSLLG 239
Cdd:PRK15030 170 NLAYTKVTSPISGRIGKSNVTEGALVQngqatalATVqqldPIYVDVTQSSND-FLRLKQELANGTLKQEngKAKVSLIT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 240 KPEVT--ASGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASVAAPAE-HSVVLPWSALSKVGEQPA-VWLLDQ 315
Cdd:PRK15030 249 SDGIKfpQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNpNAILVPQQGVTRTPRGDAtVLVVGA 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648202696 316 QSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPGQVVEVaqppQPTQSTASRDAVGGGQP 383
Cdd:PRK15030 329 DDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKA----QEVTADNNQQAASGAQP 392
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
75-252 |
4.42e-14 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 72.75 E-value: 4.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 75 VGGKIVERLVDVGDHVAAGQVLARLDPQ----------------------------DQRSNVENAQAAVAAQQAQSKLAD 126
Cdd:PRK10476 55 VGGRIVELAVTENQAVKKGDLLFRIDPRpyeltvaqaqadlaladaqimttqrsvdAERSNAASANEQVERARANAKLAT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 127 LNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAA------------------------QAQLANARDLLSYTELRAS 182
Cdd:PRK10476 135 RTLERLEPLLAKGYVSAQQVDQARTAQRDAEVSLNQAllqaqaaaaavggvdalvaqraarEAALAIAELHLEDTTVRAP 214
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 183 DAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREI 252
Cdd:PRK10476 215 FDGRVVGLKVSVGEFAAPMQPIFTLIDTDHWYAIANFRETDLKNIRVGDCATVYSMIDRGRPFEGKVDSI 284
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
60-255 |
9.92e-13 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 68.65 E-value: 9.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 60 TGDIQARVQADQSFRVGGKIVERLVDVGDHVAAGQVLARLDP---QDQRSNVE----NAQAAVAAQQAQSKLADLNYQRQ 132
Cdd:PRK11578 53 TGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPeqaENQIKEVEatlmELRAQRQQAEAELKLARVTLSRQ 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 133 KALLPKGYTSQSEYDQALA--SVRSAQ-----SSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVQAT--VP 203
Cdd:PRK11578 133 QRLAKTQAVSQQDLDTAATelAVKQAQigtidAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTVIAAqqAP 212
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 648202696 204 -IFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPT 255
Cdd:PRK11578 213 nILTLADMSTMLVKAQVSEADVIHLKPGQKAWFTVLGDPLTRYEGVLKDILPT 265
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
15-371 |
2.09e-12 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 67.90 E-value: 2.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 15 SRMALPAILCASLLVGCGAEPP---AEEHVRVLAQTVKMAEFASATSITGDIQARVQADQSFRVGGKIVERLVDVGDHVA 91
Cdd:PRK09578 7 RRLLLAALVALFVLAGCGKGDSdaaAAAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 92 AGQVLARLDPQDQRSNVENAQAAVAAQQAQSKLADLNYQRQKALLPKGYTSQSEYDQALASVRSAQSSLKAAQAQLANAR 171
Cdd:PRK09578 87 QGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAELARAQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 172 DLLSYTELRASDAGVitARQAEV--GQVV---QATvPIFTLAR-----------DGERDAVFNVYESLFSHDVDGQRITV 235
Cdd:PRK09578 167 LQLDYATVTAPIDGR--ARRALVteGALVgqdQAT-PLTTVEQldpiyvnfsqpAADVEALRRAVKSGRATGIAQQDVAV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 236 SLLgKPEVTA---SGKVREITPTVDERSGTLKVKVGLDSVPAEMSLGSVVNASV-AAPAEHSVVLPWSALSKVGEQPAVW 311
Cdd:PRK09578 244 TLV-RADGSEyplKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALdRAVNPRAILVPRDALLRTADSASVK 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648202696 312 LLDQQSKARLQPVRVARYASEKVVIDGGLEAGQTVVTVGGQLLHPG---QVVEVAQPPQPTQS 371
Cdd:PRK09578 323 VVGQNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGtavKAVERAPAAKPAPG 385
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
64-270 |
1.05e-11 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 63.68 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 64 QARVQAdqsfRVGGKIvERL--VDVGDHVAAGQVLARLDpqdqrsnvenaqaavaaqqaqskladlnyqrqkalLPKGYT 141
Cdd:pfam16576 19 LAHVHA----RVEGWI-EKLyvNATGDPVKKGQPLAELY-----------------------------------SPELVA 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 142 SQSEYDQALASVRSAQSS--LKAAQ-------------AQLANARDLLSYTELRASDAGVITARQAEVGQVVQATVPIFT 206
Cdd:pfam16576 59 AQQEYLLALRSGDALSKSelLRAARqrlrllgmpeaqiAELERTGKVQPTVTVYAPISGVVTELNVREGMYVQPGDTLFT 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 648202696 207 LARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVDERSGTLKVKVGLD 270
Cdd:pfam16576 139 IADLSTVWVEADVPEQDLALVKVGQPAEVTLPALPGKTFEGKVDYIYPTLDPKTRTVRVRIELP 202
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
178-271 |
6.00e-11 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 58.91 E-value: 6.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 178 ELRASDAGVITARQAEVGQVVQATVPIFTLARDGERDAVFNVYESLFSHDVDGQRITVSLLGKPEVTASGKVREITPTVD 257
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGDPLATIVPPDRLLVEAFVPAADLGSLKKGQKVTLKLDPGSDYTLEGKVVRISPTVD 80
|
90
....*....|....
gi 648202696 258 ERSGTLKVKVGLDS 271
Cdd:pfam13437 81 PDTGVIPVRVSIEN 94
|
|
| heterocyst_DevB |
TIGR02971 |
ABC exporter membrane fusion protein, DevB family; Members of this protein family are found ... |
141-260 |
1.18e-04 |
|
ABC exporter membrane fusion protein, DevB family; Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. DevB from Anabaena sp. strain PCC 7120 is partially characterized as a membrane fusion protein of the DevBCA ABC exporter, probably a glycolipid exporter, required for heterocyst formation. Most Cyanobacteria have one member only, but Nostoc sp. PCC 7120 has seven members.
Pssm-ID: 213754 [Multi-domain] Cd Length: 327 Bit Score: 43.66 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648202696 141 TSQSEYDQALASVRSAQSSLKAAQAQLANARDLLSYTELRASDAGVITARQAEVGQVVqATVPIFTLARDGERDAVFNVY 220
Cdd:TIGR02971 169 LASLAEEVRETDVDLAQAEVKSALEAVQQAEALLELTYVKAPIDGRVLKIHAREGEVI-GSEGILEMGDTSQMYAVAEVY 247
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 648202696 221 ESLFSHDVDGQRITVSLLGKPEvTASGKVREITPTVDERS 260
Cdd:TIGR02971 248 ETDINRVRVGQRATITSTALSG-PLRGTVRRIGSLIAKND 286
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
64-105 |
4.37e-03 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 35.11 E-value: 4.37e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 648202696 64 QARVQADQSfrvgGKIVERLVDVGDHVAAGQVLARLDPQDQR 105
Cdd:pfam13533 2 VVKIASPVS----GKVVAVNVKEGQQVKKGDVLATLDSPELQ 39
|
|
| |
