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Conserved domains on  [gi|645063695|ref|WP_025434903|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacillati]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10007659)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 5.53e-22

DNA-binding transcriptional regulator, XRE family [Transcription];


:

Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 80.19  E-value: 5.53e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 645063695  5 YKKLWKMLIDRDMKKKDLCLVAGISHASIAKL--GKNENITTDVLLRICKALDCDIGDIMEIINDDN 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLknGKAKAVRLDTLEKICKALDCQPGDLLEYVPDEE 69
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 5.53e-22

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 80.19  E-value: 5.53e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 645063695  5 YKKLWKMLIDRDMKKKDLCLVAGISHASIAKL--GKNENITTDVLLRICKALDCDIGDIMEIINDDN 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLknGKAKAVRLDTLEKICKALDCQPGDLLEYVPDEE 69
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-67 1.36e-17

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 69.11  E-value: 1.36e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 645063695   7 KLWKMLIDRDMKKKDLCLVAGISHASIAKL--GKNENITTDVLLRICKALDCDIGDIMEIIND 67
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLrkGKPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 15-61 2.61e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 34.16  E-value: 2.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 645063695  15 RDMKKKDLCLVAGISHASIAKL--GKNeNITTDVLLRICKALDCDIGDI 61
Cdd:PRK08154  40 RGMSRKVLAQASGVSERYLAQLesGQG-NVSILLLRRVARALGCSLADL 87
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 3-67 6.10e-03

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 33.26  E-value: 6.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 645063695    3 VSYKKLWKMLIDRDMKKKDLCLVAGISHASI-AKLGKNENITTDvLLRICkaldCDIGDIMEIIND 67
Cdd:TIGR01329 308 VEATKLFSITVSFGSVNSLISMPCFMSHASIpAEVREERGLPED-LVRLS----VGIEDVDDLISD 368
 
Name Accession Description Interval E-value
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
5-69 5.53e-22

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 80.19  E-value: 5.53e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 645063695  5 YKKLWKMLIDRDMKKKDLCLVAGISHASIAKL--GKNENITTDVLLRICKALDCDIGDIMEIINDDN 69
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSRLknGKAKAVRLDTLEKICKALDCQPGDLLEYVPDEE 69
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 7-67 1.36e-17

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 69.11  E-value: 1.36e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 645063695   7 KLWKMLIDRDMKKKDLCLVAGISHASIAKL--GKNENITTDVLLRICKALDCDIGDIMEIIND 67
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRLrkGKPKRVSLDTLDKICDALGCQPGDLLEYVPD 63
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
15-63 1.86e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.82  E-value: 1.86e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 645063695 15 RDMKKKDLCLVAGISHASIAKL--GKNeNITTDVLLRICKALDCDIGDIME 63
Cdd:COG1396  19 RGLTQEELAERLGVSRSTISRIerGRR-NPSLETLLKLAKALGVSLDELLG 68
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 15-61 2.61e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 34.16  E-value: 2.61e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 645063695  15 RDMKKKDLCLVAGISHASIAKL--GKNeNITTDVLLRICKALDCDIGDI 61
Cdd:PRK08154  40 RGMSRKVLAQASGVSERYLAQLesGQG-NVSILLLRRVARALGCSLADL 87
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 3-67 6.10e-03

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 33.26  E-value: 6.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 645063695    3 VSYKKLWKMLIDRDMKKKDLCLVAGISHASI-AKLGKNENITTDvLLRICkaldCDIGDIMEIIND 67
Cdd:TIGR01329 308 VEATKLFSITVSFGSVNSLISMPCFMSHASIpAEVREERGLPED-LVRLS----VGIEDVDDLISD 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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