|
Name |
Accession |
Description |
Interval |
E-value |
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
1-575 |
2.04e-74 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 251.78 E-value: 2.04e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 1 MSSSTEEQERVIQNMDKNTMVIACPGSGKSFTMkegTKAI-----FQRHPLARVSLVTFTRAATDSLKNSLQKMIEPRfL 75
Cdd:COG0210 4 LAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVL---THRIayliaEGGVDPEQILAVTFTNKAAREMRERIEALLGRL-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 76 NRIEVDTFHGF----IKKMVNQTGWKGGLLI--GHKQMAMVSRVQKHLNYHESVNDIMPFIDGIGR----ELNPDIIRIK 145
Cdd:COG0210 80 RGLWVGTFHSLalriLRRHAELLGLPPNFTIldGDDQLRLIKELLKELGLDEKRFPPRELLSLISRakneGLTPEELAEL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 146 YTRDQ-----VAFYNEYMSFCKKDNVADFNSLSKYVVGMLSAD---------KMRplsitHLIVDEVQDTDGIQFTWISE 211
Cdd:COG0210 160 LAADPewraaAELYEAYQERLRANNALDFDDLLLLAVRLLEENpevlekyqnRFR-----YILVDEYQDTNPAQYELLRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 212 HAKRGINTTIVGDDDQTIYSFRDAgGVKIFRQFDKAY-NPNVFHLTKCFRCAPLILKFADTVIRKNKARYEKSLVSgRKG 290
Cdd:COG0210 235 LAGDGRNLCVVGDDDQSIYGFRGA-DPENILRFEKDFpDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWT-DNG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 291 DKGKVTFIR--SDKAEDQF--DVIKELVEK--NPHDWAILSRNNTTLDKMESYLE---VPVTRIGGKSFWEGLEPSNILH 361
Cdd:COG0210 313 EGEKVRLYVapDEEEEARFvaDEIRELHEEgvPLSDIAVLYRTNAQSRALEEALRragIPYRVVGGLRFYERAEIKDLLA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 362 LFTFFRQPGNVGLMKRVLSFLNE--DELILDVLWKQMSVRKVTFQQ--TELPNESSVLTKMLHK--HMTLMLADTQSKEE 435
Cdd:COG0210 393 YLRLLANPDDDVALLRILNVPRRgiGAATLERLREAAREEGISLLEalRDLGELAGLSGRAAKAlrRFAELLEALRAAAE 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 436 IENRFKKIKEWLEMAGYK--MSNTKGDPSVTRI-SLMSCYRWAIK----------DGWLKMLNIAAGMtmgnkkGSSETE 502
Cdd:COG0210 473 RLPLEELLEALLDESGYEeeLREEAGEEAERRLeNLEELVDAAARfeernpgaslEAFLEELALLSDL------DAADED 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 503 QSGICLCTLHGSKGLEWKKVLIINCNHDQIPSPKVIGDEG-IEEERRLFFVGMTRAELELYITWHG-----------KPS 570
Cdd:COG0210 547 EDAVTLMTLHAAKGLEFPVVFLVGLEEGLFPHQRSLDDEEeLEEERRLFYVAITRARERLYLTYAAsrrlwgetqdnEPS 626
|
....*
gi 644807987 571 EFITE 575
Cdd:COG0210 627 RFLDE 631
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
5-249 |
9.95e-31 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 121.20 E-value: 9.95e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 5 TEEQERVIQNMDKNTMVIACPGSGKSFTMKE------GTKAIFQRHPLArvslVTFTRAATDSLKNSLQKMIEPRFLNRI 78
Cdd:pfam00580 2 NPEQRKAVTHLGGPLLVLAGAGSGKTRVLTEriayliLEGGIDPEEILA----VTFTNKAAREMKERILKLLGKAELSEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 79 EVDTFHGFIKKMVNQT----GWKGGLLI--GHKQMAMVSRVQKHLNY-----HESVNDIMPFIDGI-GRELNP---DIIR 143
Cdd:pfam00580 78 NISTFHSFCLRILRKYanriGLLPNFSIldELDQLALLKELLEKDRLnldpkLLRKLELKELISKAkNRLLSPeelQQGA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 144 IKYTRDQVA-FYNEYMSFCKKDNVADFNSLSKYVVGMLSAD----KMRPLSITHLIVDEVQDTDGIQFTWISEHAKRGIN 218
Cdd:pfam00580 158 ADPRDKLAAeFYQEYQERLKENNALDFDDLLLLTLELLRSDpellEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHEN 237
|
250 260 270
....*....|....*....|....*....|.
gi 644807987 219 TTIVGDDDQTIYSFRDAgGVKIFRQFDKAYN 249
Cdd:pfam00580 238 LFLVGDPDQSIYGFRGA-DIENILKFEKDFP 267
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
5-257 |
1.81e-29 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 114.92 E-value: 1.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 5 TEEQERVIQNMDKNTMVIACPGSGKSFTMKEGTKAIFQRHPLA--RVSLVTFTRAATDSLKNSLQKMIEPRFLNRIEVDT 82
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPpeRILAVTFTNKAAKEMRERLRKLLGEQLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 83 FHGFIKKMVnqtgwkggllighkqmamvsrvQKHLNYHesvndimpfidgigrelnpDIIR--IKYTRDQVAFYNEYMSF 160
Cdd:cd17932 81 FHSFALRIL----------------------RRYGDFD-------------------DLLLyaLELLEENPDVREKLQSR 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 161 CKkdnvadfnslskyvvgmlsadkmrplsitHLIVDEVQDTDGIQFTWISEHAKRGINTTIVGDDDQTIYSFRDAgGVKI 240
Cdd:cd17932 120 FR-----------------------------YILVDEYQDTNPLQYELLKLLAGDGKNLFVVGDDDQSIYGFRGA-DPEN 169
|
250
....*....|....*...
gi 644807987 241 FRQFDKAY-NPNVFHLTK 257
Cdd:cd17932 170 ILDFEKDFpDAKVIKLEE 187
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
18-587 |
2.03e-23 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 104.95 E-value: 2.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 18 NTMVIACPGSGKsftmkegTKAIFQR----HPLARVSL-----VTFTRAATDSLKNSLQKMIE--PRflnRIEVDTFHGF 86
Cdd:PRK11773 24 NMLVLAGAGSGK-------TRVLVHRiawlMQVENASPysimaVTFTNKAAAEMRHRIEQLLGtsQG---GMWVGTFHGL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 87 IKKMVnQTGWK-GGL------LIGHKQMAMVSRVQKHLNYHES---VNDIMPFIDGIGRE-LNPDIIRI---KYTRDQVA 152
Cdd:PRK11773 94 AHRLL-RAHWQdANLpqdfqiLDSDDQLRLLKRLIKALNLDEKqwpPRQAQWYINGQKDEgLRPQHIQSygdPVEQTWLK 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 153 FYNEYMSFCKKDNVADFNSLskyvvgMLSA-----DKMRPLS-----ITHLIVDEVQDTDGIQFTWISEHAKRGINTTIV 222
Cdd:PRK11773 173 IYQAYQEACDRAGLVDFAEL------LLRAhelwlNKPHILQhyqerFTHILVDEFQDTNAIQYAWIRLLAGDTGKVMIV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 223 GDDDQTIYSFRdagGVKI--FRQFDKAY-NPNVFHLTKCFRCAPLILKFADTVIRKNKARYEKSL-VSGRKGDKGKV--T 296
Cdd:PRK11773 247 GDDDQSIYGWR---GAQVenIQRFLNDFpGAETIRLEQNYRSTANILKAANALIANNNGRLGKELwTDGGDGEPISLycA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 297 FIRSDKAedQFDV--IKELVEK--NPHDWAILSRNNTTLDKMESYL---EVPVtRI-GGKSFWEGLEPSNIL-HLftffr 367
Cdd:PRK11773 324 FNELDEA--RFVVerIKTWQDNggALSDCAILYRSNAQSRVLEEALlqaGIPY-RIyGGMRFFERQEIKDALaYL----- 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 368 qpgnvglmkRVLSFLNED---------------ELILDVLWKQMSVRKVT-FQQTELPNESSVLT----KMLHKHMTLML 427
Cdd:PRK11773 396 ---------RLIANRNDDaafervvntptrgigDRTLDVVRQTARDRQLTlWQACRALLQEKVLAgraaSALQRFIELID 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 428 ADTQSKEEIEnRFKKIKEWLEMAG-YKM-SNTKGDPSVTRI----SLMSCYRWAIK---DGWLKMLN-------IAAGmt 491
Cdd:PRK11773 467 ALAQETADMP-LHEQTDRVIKDSGlRAMyEQEKGEKGQARIenleELVTATRQFSYpdeDEDLTPLQaflshaaLEAG-- 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 492 mgnkKGSSETEQSGICLCTLHGSKGLEWKKVLIINCNHDQIPSPKVIgDEG--IEEERRLFFVGMTRAELELYITW---- 565
Cdd:PRK11773 544 ----EGQADAHEDAVQLMTLHSAKGLEFPLVFIVGMEEGLFPSQMSL-EEGgrLEEERRLAYVGITRAMQKLTLTYaesr 618
|
650 660
....*....|....*....|....*....
gi 644807987 566 --HGK-----PSEFITEsFPKvvELAEEI 587
Cdd:PRK11773 619 rlYGKevyhrPSRFIRE-IPE--ECVEEV 644
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
190-322 |
2.26e-08 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 57.39 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 190 ITHLIVDEVQDTDGIQFTWIS---------EHAKRGINTTI--VGDDDQTIYSFR-------DAGGVKIFRQFDKAYNPn 251
Cdd:TIGR02784 391 IDHILVDEAQDTSPEQWDIIQalaeeffsgEGARSGVERTIfaVGDEKQSIYSFQgadperfAEERREFSRKVRAVGRK- 469
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644807987 252 vFH---LTKCFRCAPLILKFADTVIRKNKARyekslvSGRKGDKGKVTF--IRSDK--AEDQFDVIKELVEKNPHDWA 322
Cdd:TIGR02784 470 -FEdlsLNYSFRSTPDVLAAVDLVFADPENA------RGLSADSDAPVHeaFRDDLpgRVDLWDLISKEEGEEPEDWT 540
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
1-575 |
2.04e-74 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 251.78 E-value: 2.04e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 1 MSSSTEEQERVIQNMDKNTMVIACPGSGKSFTMkegTKAI-----FQRHPLARVSLVTFTRAATDSLKNSLQKMIEPRfL 75
Cdd:COG0210 4 LAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVL---THRIayliaEGGVDPEQILAVTFTNKAAREMRERIEALLGRL-A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 76 NRIEVDTFHGF----IKKMVNQTGWKGGLLI--GHKQMAMVSRVQKHLNYHESVNDIMPFIDGIGR----ELNPDIIRIK 145
Cdd:COG0210 80 RGLWVGTFHSLalriLRRHAELLGLPPNFTIldGDDQLRLIKELLKELGLDEKRFPPRELLSLISRakneGLTPEELAEL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 146 YTRDQ-----VAFYNEYMSFCKKDNVADFNSLSKYVVGMLSAD---------KMRplsitHLIVDEVQDTDGIQFTWISE 211
Cdd:COG0210 160 LAADPewraaAELYEAYQERLRANNALDFDDLLLLAVRLLEENpevlekyqnRFR-----YILVDEYQDTNPAQYELLRL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 212 HAKRGINTTIVGDDDQTIYSFRDAgGVKIFRQFDKAY-NPNVFHLTKCFRCAPLILKFADTVIRKNKARYEKSLVSgRKG 290
Cdd:COG0210 235 LAGDGRNLCVVGDDDQSIYGFRGA-DPENILRFEKDFpDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWT-DNG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 291 DKGKVTFIR--SDKAEDQF--DVIKELVEK--NPHDWAILSRNNTTLDKMESYLE---VPVTRIGGKSFWEGLEPSNILH 361
Cdd:COG0210 313 EGEKVRLYVapDEEEEARFvaDEIRELHEEgvPLSDIAVLYRTNAQSRALEEALRragIPYRVVGGLRFYERAEIKDLLA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 362 LFTFFRQPGNVGLMKRVLSFLNE--DELILDVLWKQMSVRKVTFQQ--TELPNESSVLTKMLHK--HMTLMLADTQSKEE 435
Cdd:COG0210 393 YLRLLANPDDDVALLRILNVPRRgiGAATLERLREAAREEGISLLEalRDLGELAGLSGRAAKAlrRFAELLEALRAAAE 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 436 IENRFKKIKEWLEMAGYK--MSNTKGDPSVTRI-SLMSCYRWAIK----------DGWLKMLNIAAGMtmgnkkGSSETE 502
Cdd:COG0210 473 RLPLEELLEALLDESGYEeeLREEAGEEAERRLeNLEELVDAAARfeernpgaslEAFLEELALLSDL------DAADED 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 503 QSGICLCTLHGSKGLEWKKVLIINCNHDQIPSPKVIGDEG-IEEERRLFFVGMTRAELELYITWHG-----------KPS 570
Cdd:COG0210 547 EDAVTLMTLHAAKGLEFPVVFLVGLEEGLFPHQRSLDDEEeLEEERRLFYVAITRARERLYLTYAAsrrlwgetqdnEPS 626
|
....*
gi 644807987 571 EFITE 575
Cdd:COG0210 627 RFLDE 631
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
1-576 |
2.09e-33 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 136.25 E-value: 2.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 1 MSSS--TEEQERVIQNMDKNTMVIACPGSGKSFTMkegTKAIFQ---RHPLA--RVSLVTFTRAATDSLKN----SLQKM 69
Cdd:COG1074 1 MSEPpwTDAQRRALDPLGGSVLVEASAGSGKTYTL---VARYLRlllERGLDpeEILVVTFTRAAAAEMRErireRLAEA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 70 IEP------------RFLNRIE-------VDTFHGFIKKMVNQTGWKGGL------------------------------ 100
Cdd:COG1074 78 ADLedpdleelararRRLARALenldraaISTIHSFCQRLLREFAFEAGLdpnfellddaeallleeavddllreayapl 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 101 -------LIGH---------KQMAMVSRVQKHLNYHESVNDIMPFIDGIGRELNPDIIRIKYTRDQV------------- 151
Cdd:COG1074 158 dalalarLLDAfgrdddsleELLLALYKLRSRPDWLEELAELDEALEALREALLKAKEALAALREALaaaaapllaallr 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 152 ---AFYNEYMSFCKKDNVADFNSLSKYVVGMLS-------ADKMRpLSITHLIVDEVQDTDGIQF----TWISEHAKRGI 217
Cdd:COG1074 238 llaAVLARYERRKRERGLLDFDDLLHRALRLLRdedapwvAERLR-ERYRHILVDEFQDTSPLQWeilrRLAGEALADGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 218 NTTIVGDDDQTIYSFRDAggvKIF------RQFDKAYNPNVFHLTKCFRCAPLILKFADTVIRKNKAR------YEkSLV 285
Cdd:COG1074 317 TLFLVGDPKQSIYRFRGA---DPElflearRALEGRVDGERLTLTTNFRSTPEVVDAVNALFAQLMGAgfgeipYE-PVE 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 286 SGRKGDKGKVTFIRSDKAEDQFDV------------IKELVEKN-----------PHDWAILSRNNTTLDKMESYLE--- 339
Cdd:COG1074 393 ALRPGAYPAVELWPLEPDDVSEEDarerearavaarIRRLLAEGttvegggrpvrPGDIAVLVRTRSEAAAIARALKaag 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 340 VPVTRIGGKSFWEGLEPSNILHLFTFFRQPGNVGLMKRVLS----FLNEDELI-------LDVLWKQMS--------VRK 400
Cdd:COG1074 473 IPVAASDRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRsplfGLSDEDLAalaadrkGESLWEALRayerlaraLER 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 401 VTFQQTELPNES--SVLTKMLHKH--MTLMLADTQSKEEIENRFkKIKEWLEMA-GYKMSNTKGDPSVTRislmscyrwa 475
Cdd:COG1074 553 LRALRELARRLGlaELLERLLEETglLERLLALPGGERRLANLL-HLDELLQLAlEYEQTGGPGLAGFLR---------- 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 476 ikdgWLKMLNIAAGmtmGNKKGSSETEQSGICLCTLHGSKGLEWKKVLIincnhdqipsPKV---IGDEGIEEERRLFFV 552
Cdd:COG1074 622 ----WLERLIEDGG---DEEKRRLESDADAVRIMTIHKSKGLEFPVVFL----------PALrerARAEELAEELRLLYV 684
|
730 740
....*....|....*....|....
gi 644807987 553 GMTRAELELYITWHGKPSEFITES 576
Cdd:COG1074 685 ALTRARDRLVLSGAVKKKDAEKES 708
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
5-249 |
9.95e-31 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 121.20 E-value: 9.95e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 5 TEEQERVIQNMDKNTMVIACPGSGKSFTMKE------GTKAIFQRHPLArvslVTFTRAATDSLKNSLQKMIEPRFLNRI 78
Cdd:pfam00580 2 NPEQRKAVTHLGGPLLVLAGAGSGKTRVLTEriayliLEGGIDPEEILA----VTFTNKAAREMKERILKLLGKAELSEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 79 EVDTFHGFIKKMVNQT----GWKGGLLI--GHKQMAMVSRVQKHLNY-----HESVNDIMPFIDGI-GRELNP---DIIR 143
Cdd:pfam00580 78 NISTFHSFCLRILRKYanriGLLPNFSIldELDQLALLKELLEKDRLnldpkLLRKLELKELISKAkNRLLSPeelQQGA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 144 IKYTRDQVA-FYNEYMSFCKKDNVADFNSLSKYVVGMLSAD----KMRPLSITHLIVDEVQDTDGIQFTWISEHAKRGIN 218
Cdd:pfam00580 158 ADPRDKLAAeFYQEYQERLKENNALDFDDLLLLTLELLRSDpellEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHEN 237
|
250 260 270
....*....|....*....|....*....|.
gi 644807987 219 TTIVGDDDQTIYSFRDAgGVKIFRQFDKAYN 249
Cdd:pfam00580 238 LFLVGDPDQSIYGFRGA-DIENILKFEKDFP 267
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
5-257 |
1.81e-29 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 114.92 E-value: 1.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 5 TEEQERVIQNMDKNTMVIACPGSGKSFTMKEGTKAIFQRHPLA--RVSLVTFTRAATDSLKNSLQKMIEPRFLNRIEVDT 82
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPpeRILAVTFTNKAAKEMRERLRKLLGEQLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 83 FHGFIKKMVnqtgwkggllighkqmamvsrvQKHLNYHesvndimpfidgigrelnpDIIR--IKYTRDQVAFYNEYMSF 160
Cdd:cd17932 81 FHSFALRIL----------------------RRYGDFD-------------------DLLLyaLELLEENPDVREKLQSR 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 161 CKkdnvadfnslskyvvgmlsadkmrplsitHLIVDEVQDTDGIQFTWISEHAKRGINTTIVGDDDQTIYSFRDAgGVKI 240
Cdd:cd17932 120 FR-----------------------------YILVDEYQDTNPLQYELLKLLAGDGKNLFVVGDDDQSIYGFRGA-DPEN 169
|
250
....*....|....*...
gi 644807987 241 FRQFDKAY-NPNVFHLTK 257
Cdd:cd17932 170 ILDFEKDFpDAKVIKLEE 187
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
18-587 |
2.03e-23 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 104.95 E-value: 2.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 18 NTMVIACPGSGKsftmkegTKAIFQR----HPLARVSL-----VTFTRAATDSLKNSLQKMIE--PRflnRIEVDTFHGF 86
Cdd:PRK11773 24 NMLVLAGAGSGK-------TRVLVHRiawlMQVENASPysimaVTFTNKAAAEMRHRIEQLLGtsQG---GMWVGTFHGL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 87 IKKMVnQTGWK-GGL------LIGHKQMAMVSRVQKHLNYHES---VNDIMPFIDGIGRE-LNPDIIRI---KYTRDQVA 152
Cdd:PRK11773 94 AHRLL-RAHWQdANLpqdfqiLDSDDQLRLLKRLIKALNLDEKqwpPRQAQWYINGQKDEgLRPQHIQSygdPVEQTWLK 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 153 FYNEYMSFCKKDNVADFNSLskyvvgMLSA-----DKMRPLS-----ITHLIVDEVQDTDGIQFTWISEHAKRGINTTIV 222
Cdd:PRK11773 173 IYQAYQEACDRAGLVDFAEL------LLRAhelwlNKPHILQhyqerFTHILVDEFQDTNAIQYAWIRLLAGDTGKVMIV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 223 GDDDQTIYSFRdagGVKI--FRQFDKAY-NPNVFHLTKCFRCAPLILKFADTVIRKNKARYEKSL-VSGRKGDKGKV--T 296
Cdd:PRK11773 247 GDDDQSIYGWR---GAQVenIQRFLNDFpGAETIRLEQNYRSTANILKAANALIANNNGRLGKELwTDGGDGEPISLycA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 297 FIRSDKAedQFDV--IKELVEK--NPHDWAILSRNNTTLDKMESYL---EVPVtRI-GGKSFWEGLEPSNIL-HLftffr 367
Cdd:PRK11773 324 FNELDEA--RFVVerIKTWQDNggALSDCAILYRSNAQSRVLEEALlqaGIPY-RIyGGMRFFERQEIKDALaYL----- 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 368 qpgnvglmkRVLSFLNED---------------ELILDVLWKQMSVRKVT-FQQTELPNESSVLT----KMLHKHMTLML 427
Cdd:PRK11773 396 ---------RLIANRNDDaafervvntptrgigDRTLDVVRQTARDRQLTlWQACRALLQEKVLAgraaSALQRFIELID 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 428 ADTQSKEEIEnRFKKIKEWLEMAG-YKM-SNTKGDPSVTRI----SLMSCYRWAIK---DGWLKMLN-------IAAGmt 491
Cdd:PRK11773 467 ALAQETADMP-LHEQTDRVIKDSGlRAMyEQEKGEKGQARIenleELVTATRQFSYpdeDEDLTPLQaflshaaLEAG-- 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 492 mgnkKGSSETEQSGICLCTLHGSKGLEWKKVLIINCNHDQIPSPKVIgDEG--IEEERRLFFVGMTRAELELYITW---- 565
Cdd:PRK11773 544 ----EGQADAHEDAVQLMTLHSAKGLEFPLVFIVGMEEGLFPSQMSL-EEGgrLEEERRLAYVGITRAMQKLTLTYaesr 618
|
650 660
....*....|....*....|....*....
gi 644807987 566 --HGK-----PSEFITEsFPKvvELAEEI 587
Cdd:PRK11773 619 rlYGKevyhrPSRFIRE-IPE--ECVEEV 644
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
8-564 |
4.62e-22 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 100.69 E-value: 4.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 8 QERVIQNMDKNTMVIACPGSGKSFTMKEGTKAIFQ------RHplarVSLVTFTRAATDSLKNSLQKMIEPRFLNRIEVD 81
Cdd:PRK10919 7 QQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRgcgyqaRH----IAAVTFTNKAAREMKERVAQTLGRKEARGLMIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 82 TFHGF----IKKMVNQTGWKG--GLLIGHKQMAMVSRVQKHLnYHESVNDIMPFIDGIGRELNpDII-------RIKYTR 148
Cdd:PRK10919 83 TFHTLgldiIKREYAALGMKSnfSLFDDTDQLALLKELTEGL-IEDDKVLLQQLISTISNWKN-DLKtpaqaaaGAKGER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 149 DQV-----AFYNEYMSFCkkdNVADFNSL-SKYVVGMLSADKMRPL---SITHLIVDEVQDTDGIQFTWISEHAKRGINT 219
Cdd:PRK10919 161 DRIfahcyGLYDAHLKAC---NVLDFDDLiLLPTLLLQRNEEVRERwqnKIRYLLVDEYQDTNTSQYELVKLLVGSRARF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 220 TIVGDDDQTIYSFRDA---GGVKIFRQFDKAynpNVFHLTKCFRCAPLILKFADTVIRKNKARYEKSLVSGRK-GDKGKV 295
Cdd:PRK10919 238 TVVGDDDQSIYSWRGArpqNLVLLSQDFPAL---QVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGyGDELKV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 296 TFIRSDKAEDQfDVIKELV------EKNPHDWAILSRNNTTLDKMESYL---EVPVTRIGGKSFWEGLEPSNILHLFTFF 366
Cdd:PRK10919 315 LSANNEEHEAE-RVTGELIahhfvnKTQYKDYAILYRGNHQSRVFEKFLmqnRIPYKISGGTSFFSRPEIKDLLAYLRVL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 367 RQPGNVGLMKRVLSFLNED--ELILDVLWKQMSVR-KVTFQQT-ELPNESSVLTKMLH--KHMTLMLADTQSKEEIENrF 440
Cdd:PRK10919 394 TNPDDDSAFLRIVNTPKREigPATLQKLGEWAMTRnKSLFTASfDMGLSQTLSGRGYEslTRFTHWLAEIQRLAEREP-V 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 441 KKIKEWLEMAGYK--MSNTKGDPSVTRISLMSCYRWAikdGWL-KML---NIAAGMTMGN-----------KKGSSETEQ 503
Cdd:PRK10919 473 AAVRDLIHGIDYEswLYETSPSPKAAEMRMKNVNQLF---SWMtEMLegsELDEPMTLTQvvtrftlrdmmERGESEEEL 549
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644807987 504 SGICLCTLHGSKGLEWKKVLIINCNHDQIPSPKVIGDEGIEEERRLFFVGMTRAELELYIT 564
Cdd:PRK10919 550 DQVQLMTLHASKGLEFPYVYLVGMEEGLLPHQSSIDEDNIDEERRLAYVGITRAQKELTFT 610
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
253-566 |
1.31e-19 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 90.93 E-value: 1.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 253 FHLTKCFRCAPLILKFADTVIRKNKARYEKSLV-----SGRKGDKGKV--TFIRSDKAEDQFDVIKELVEKNPH--DWAI 323
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRATIYPKkilaeTVEDGEKIKIieAETEEEEAEWIALEIKKLVARDEKynDIAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 324 LSRNNTTLDKMESYLE---VPVTRIGGKSFWEGLEPSNILHLFTFFRQPGNVGLMKRVLS-------------------- 380
Cdd:pfam13361 81 LTRSNSDADLIEEALKklgIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNgpkrgignatlerireykkr 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 381 ----------------------FLNEDELILDVLWKQMSVRKVTFQQTELP--NESSVLTKMLHKHMTLmladtqsKEEI 436
Cdd:pfam13361 161 glrlsdfinpdtltygdpfviaLEQDNIVVFDVETTGLDTTEDEIIQIAAIklNKKGVVIESFERFLRL-------KKPV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 437 ENRFKKIKEWLEMAGYKMSNTKG--DPSVTRIS-LMSCYRWA-----------IKDGWLKMLNIAAgMTMGNKKGSSETE 502
Cdd:pfam13361 234 GDSLQVHGFSDEFLQENGETPAEalRDFLEKLEnLRELYSILreyddieetpePEDALRNFLEIAT-LSNSELEGSDIKE 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644807987 503 QsgICLCTLHGSKGLEWKKVLIINCNHDQIPSPKVIGDEG-IEEERRLFFVGMTRAELELYITWH 566
Cdd:pfam13361 313 R--IPIMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIKDEGnLEEERRLFYVAITRAKKRLYISYS 375
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
506-565 |
6.06e-18 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 80.74 E-value: 6.06e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644807987 506 ICLCTLHGSKGLEWKKVLIINCNHDQIPSP-----KVIGDEGIEEERRLFFVGMTRAELELYITW 565
Cdd:cd18807 86 VTLMTIHASKGLEFPVVFIVGLGEGFIPSDasyhaAKEDEERLEEERRLLYVALTRAKKELYLVG 150
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
153-339 |
2.18e-11 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 66.92 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 153 FYNEYMSFC----KKDNVADFNSLSKYVVGMLSADKM-------RPLS-ITHLIVDEVQDTDGIQFTWIS---EHAKRGI 217
Cdd:PRK13909 280 LLQLYKEAKnelnKKKNALDFDDISKKVYELLGEEEIdkdflyfRLDSkISHILIDEFQDTSVLQYKILLpliDEIKSGE 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 218 NTT------IVGDDDQTIYSFRdaGGVK-IFRQFDKAYNPNVFHLTKCFRCAPLILKFADTVIrKNKARYEKSLVSGRKG 290
Cdd:PRK13909 360 GQKkfrsffYVGDVKQSIYRFR--GGKKeLFDKVSKDFKQKVDNLDTNYRSAPLIVDFVNEVF-KKKYKNYKTQYAEQHK 436
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 644807987 291 DKGKV-----TFIRSDKAEDQFDVIKELVEK--NPHDWAILSRNNTTLDKMESYLE 339
Cdd:PRK13909 437 SGGYVevvevADESEELLEQLLQEIQFLLEKgiDPDDIAILCWTNDDALEIKEFLQ 492
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
190-322 |
2.26e-08 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 57.39 E-value: 2.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 190 ITHLIVDEVQDTDGIQFTWIS---------EHAKRGINTTI--VGDDDQTIYSFR-------DAGGVKIFRQFDKAYNPn 251
Cdd:TIGR02784 391 IDHILVDEAQDTSPEQWDIIQalaeeffsgEGARSGVERTIfaVGDEKQSIYSFQgadperfAEERREFSRKVRAVGRK- 469
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644807987 252 vFH---LTKCFRCAPLILKFADTVIRKNKARyekslvSGRKGDKGKVTF--IRSDK--AEDQFDVIKELVEKNPHDWA 322
Cdd:TIGR02784 470 -FEdlsLNYSFRSTPDVLAAVDLVFADPENA------RGLSADSDAPVHeaFRDDLpgRVDLWDLISKEEGEEPEDWT 540
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
510-564 |
2.26e-07 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 47.57 E-value: 2.26e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 644807987 510 TLHGSKGLEWKKVLIINCNHDQipspkvigDEGIEEERRLFFVGMTRAELELYIT 564
Cdd:pfam13538 6 TVHKAQGSEFPAVFLVDPDLTA--------HYHSMLRRRLLYTAVTRARKKLVLV 52
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
183-316 |
1.23e-06 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 51.40 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 183 DKMRPLSITHLIVDEVQDTDGIQF---TWISEHAKRgintTIVGDDDQTIYSFRDAGGvkiFRQFDKAYNP---NVFHLT 256
Cdd:COG3973 463 GPDRTWTYGHVVVDEAQDLSPMQWrvlKRRFPSASF----TIVGDLAQAIHPYRGAES---WEEVLEPLGGdraRLVELT 535
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644807987 257 KCFRCAPLILKFADTVIRK-----NKARyekSLVsgRKGDkgKVTFIRSDKAEDQFDVIKELVEK 316
Cdd:COG3973 536 KSYRSTAEIMEFANRVLRAagpdlPPPE---SVR--RHGE--PPRVVRVPSEAELAAAVVEAVRE 593
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
510-575 |
1.96e-05 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 47.64 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644807987 510 TLHGSKGLEWKKVLIINCNHDQIPSPKVIGDEGIE-------------EERRLFFVGMTRAELELYITWH-GKPSEFITE 575
Cdd:PRK11054 593 TIHASKGQQADYVIILGLQEGQDGFPAPARESIMEeallpppedfpdaEERRLLYVALTRAKHRVWLLFNkGNPSPFVEE 672
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
183-233 |
2.62e-04 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 41.43 E-value: 2.62e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 644807987 183 DKMRPLSITHLIVDEVQDTDGI-QFTWISEhAKRGINTTIVGDDDQTIYSFR 233
Cdd:pfam13245 86 DEEEPLDGDLLIVDEFSMVDLPlAYRLLKA-LPDGAQLLLVGDPDQLPSVGP 136
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
181-241 |
6.47e-04 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 39.78 E-value: 6.47e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644807987 181 SADKMRplsitHLIVDEVQDTDGIQFTWISEHAKRGINTTIVGDDDQTIYSFRDAGGVKIF 241
Cdd:cd17914 43 AAAQLD-----NILVDEAAQILEPETSRLIDLALDQGRVILVGDHDQLGPVWRGAVLAKIC 98
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
510-564 |
1.41e-03 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 38.19 E-value: 1.41e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 644807987 510 TLHGSKGLEWKKVLIIncnhdqIPSPKvigdegiEEERRLFFVGMTRAELELYIT 564
Cdd:cd18786 47 TIDSSQGLTFDVVTLY------LPTAN-------SLTPRRLYVALTRARKRLVIY 88
|
|
| |
