NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|644586095|ref|WP_025337179|]
View 

MULTISPECIES: 1-acyl-sn-glycerol-3-phosphate acyltransferase [Pseudomonas]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-238 1.95e-58

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 184.83  E-value: 1.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  36 APFLSFPKRYKFINVyWCRCALFLvrtiLGIDYKITGAENVPDE-PCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLY 113
Cdd:COG0204    4 LFLLLRRFRYRLVRL-WARLLLRL----LGVRVRVEGLENLPADgPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 114 VPFFGWAMAMLRPIAINRDNPKEALRQVAsKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAHN 193
Cdd:COG0204   79 IPLLGWLLRALGAIPVDRSKRRAALRALR-QAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAID 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 644586095 194 AGKFWPKTGWGKRAGTIEVVIGEPMYANGTGPRAIAELNDRAAAW 238
Cdd:COG0204  158 GTERALPKGFLPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAA 202
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-238 1.95e-58

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 184.83  E-value: 1.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  36 APFLSFPKRYKFINVyWCRCALFLvrtiLGIDYKITGAENVPDE-PCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLY 113
Cdd:COG0204    4 LFLLLRRFRYRLVRL-WARLLLRL----LGVRVRVEGLENLPADgPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 114 VPFFGWAMAMLRPIAINRDNPKEALRQVAsKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAHN 193
Cdd:COG0204   79 IPLLGWLLRALGAIPVDRSKRRAALRALR-QAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAID 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 644586095 194 AGKFWPKTGWGKRAGTIEVVIGEPMYANGTGPRAIAELNDRAAAW 238
Cdd:COG0204  158 GTERALPKGFLPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAA 202
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 59-234 5.03e-47

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 154.74  E-value: 5.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  59 LVRTILGIDYKITGAENVP-DEPCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLYVPFFGWAMAMLRPIAINRDNP-- 134
Cdd:cd07989    3 LLLRLLGVRVRVEGLENLPpKGPVIIVANHQSYLDPLVLGAALPrPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGrs 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 135 -KEALRQVAskgdELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIA-HNAGKFWPKTGWGKRAGTIEV 212
Cdd:cd07989   83 aREALREAI----EALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAiSGTWGSLPKGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....
gi 644586095 213 VIGEPMYANGTGPR--AIAELNDR 234
Cdd:cd07989  159 RIGEPIPPEGLELAeeDRKELREK 182
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 81-193 9.35e-30

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 108.21  E-value: 9.35e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095    81 CVILSNHQSTWETFFLSQYF----SPLSQVLKRELLYVPFFGWAMAMLRPIAINRDNPKEALRQVAsKGDELLKQKTWVL 156
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLprklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALR-EAVELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 644586095   157 IFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAHN 193
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 69-192 1.67e-25

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 97.35  E-value: 1.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095   69 KITGAENVP-DEPCVILSNHQSTWETFFLS----QYFSPLSQVLKRELLYVPFFGWAMAMLRPIAINRDNPKEALRqVAS 143
Cdd:pfam01553   3 EVHGLENLPrGGPAIVVANHQSYLDVLLLSlalyKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG-TLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 644586095  144 KGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAH 192
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 65-191 1.74e-25

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 97.42  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095   65 GIDYKITGAENVP-DEPCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLYVPFFGWAMAMLRPIAINRDNpKEALRQVA 142
Cdd:TIGR00530   1 GLKVEVVGPENLPaKSPVLVVANHQSNLDPLTLSAAFPpPIVFIAKKELKWIPFFGIMLWLTGAIFIDREN-IRAIATAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 644586095  143 SKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIA 191
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVV 128
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 37-221 3.08e-24

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 96.72  E-value: 3.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  37 PFLSFPKRYK-----FINVYWCRCALFLVRTIlgidyKITGAENVP--DEPCVILSNHQSTWETFFLSQYFSPLSQVLKR 109
Cdd:PLN02901   6 PFVLLFDRYRrkaqhFINKVWATLSTSPFYKI-----EVEGLENLPspDEPAVYVSNHQSFLDIYTLFHLGRPFKFISKT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 110 ELLYVPFFGWAMAMLRPIAINRDNPKEALrQVASKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLP 189
Cdd:PLN02901  81 SIFLIPIIGWAMYMTGHIPLKRMDRRSQL-ECLKRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVP 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 644586095 190 IA-HNAGKFWPkTG--WGKRAGTIEVVIGEPMYAN 221
Cdd:PLN02901 160 ITlVGTGKIMP-NGkeGILNPGSVKVVIHPPIEGS 193
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-238 1.95e-58

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 184.83  E-value: 1.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  36 APFLSFPKRYKFINVyWCRCALFLvrtiLGIDYKITGAENVPDE-PCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLY 113
Cdd:COG0204    4 LFLLLRRFRYRLVRL-WARLLLRL----LGVRVRVEGLENLPADgPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 114 VPFFGWAMAMLRPIAINRDNPKEALRQVAsKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAHN 193
Cdd:COG0204   79 IPLLGWLLRALGAIPVDRSKRRAALRALR-QAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAID 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 644586095 194 AGKFWPKTGWGKRAGTIEVVIGEPMYANGTGPRAIAELNDRAAAW 238
Cdd:COG0204  158 GTERALPKGFLPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAA 202
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 59-234 5.03e-47

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 154.74  E-value: 5.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  59 LVRTILGIDYKITGAENVP-DEPCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLYVPFFGWAMAMLRPIAINRDNP-- 134
Cdd:cd07989    3 LLLRLLGVRVRVEGLENLPpKGPVIIVANHQSYLDPLVLGAALPrPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGrs 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 135 -KEALRQVAskgdELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIA-HNAGKFWPKTGWGKRAGTIEV 212
Cdd:cd07989   83 aREALREAI----EALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAiSGTWGSLPKGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....
gi 644586095 213 VIGEPMYANGTGPR--AIAELNDR 234
Cdd:cd07989  159 RIGEPIPPEGLELAeeDRKELREK 182
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 81-193 9.35e-30

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 108.21  E-value: 9.35e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095    81 CVILSNHQSTWETFFLSQYF----SPLSQVLKRELLYVPFFGWAMAMLRPIAINRDNPKEALRQVAsKGDELLKQKTWVL 156
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLprklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALR-EAVELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 644586095   157 IFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAHN 193
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 69-192 1.67e-25

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 97.35  E-value: 1.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095   69 KITGAENVP-DEPCVILSNHQSTWETFFLS----QYFSPLSQVLKRELLYVPFFGWAMAMLRPIAINRDNPKEALRqVAS 143
Cdd:pfam01553   3 EVHGLENLPrGGPAIVVANHQSYLDVLLLSlalyKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG-TLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 644586095  144 KGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIAH 192
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 65-191 1.74e-25

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 97.42  E-value: 1.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095   65 GIDYKITGAENVP-DEPCVILSNHQSTWETFFLSQYFS-PLSQVLKRELLYVPFFGWAMAMLRPIAINRDNpKEALRQVA 142
Cdd:TIGR00530   1 GLKVEVVGPENLPaKSPVLVVANHQSNLDPLTLSAAFPpPIVFIAKKELKWIPFFGIMLWLTGAIFIDREN-IRAIATAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 644586095  143 SKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLPIA 191
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVV 128
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 37-221 3.08e-24

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 96.72  E-value: 3.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  37 PFLSFPKRYK-----FINVYWCRCALFLVRTIlgidyKITGAENVP--DEPCVILSNHQSTWETFFLSQYFSPLSQVLKR 109
Cdd:PLN02901   6 PFVLLFDRYRrkaqhFINKVWATLSTSPFYKI-----EVEGLENLPspDEPAVYVSNHQSFLDIYTLFHLGRPFKFISKT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 110 ELLYVPFFGWAMAMLRPIAINRDNPKEALrQVASKGDELLKQKTWVLIFPEGTRVPFGTMGKFSRGGTALAVNAGLPVLP 189
Cdd:PLN02901  81 SIFLIPIIGWAMYMTGHIPLKRMDRRSQL-ECLKRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVP 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 644586095 190 IA-HNAGKFWPkTG--WGKRAGTIEVVIGEPMYAN 221
Cdd:PLN02901 160 ITlVGTGKIMP-NGkeGILNPGSVKVVIHPPIEGS 193
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 53-191 2.97e-18

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 80.34  E-value: 2.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  53 CRCALFlvrtILGIdYKIT--GAENVPDEPCVILSNHQSTWETFFLSQYFSPlSQVLKRELLYVPFFGWAMAMLRPIAIN 130
Cdd:cd07991    1 ARVLLF----AFGF-YVIKvhGKPDPPEAPRIIVANHTSFIDPLILFSDLFP-SIVAKKELGKLPFIGTILRALGCIFVD 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644586095 131 RDNPKEalRQVASkgdELLKQKTW------VLIFPEGTrvpfGTMGK----FSRGgtalAVNAGLPVLPIA 191
Cdd:cd07991   75 RSEPKD--RKKVV---EEIKERATdpnwppILIFPEGT----TTNGKalimFKKG----AFEPGVPVQPVA 132
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 57-163 3.08e-18

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 79.98  E-value: 3.08e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  57 LFLVRTILGIDYKITGAE-NVPDEPCVILSNHQSTWETFFL---SQYFSPLSQ---VLKRELLYVPFFGWAMAMLRPIAI 129
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEpKLPKERALIISNHRSEVDWLVLwmlADRFGRLGRlkiVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 644586095 130 NRDNPKEalRQVASKGDELLK---QKTWVLIFPEGTR 163
Cdd:cd07990   81 KRKWEKD--EKTIKRQLKRLKdspEPFWLLIFPEGTR 115
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 57-217 8.53e-14

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 67.82  E-value: 8.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  57 LFLVRTILGIDYKITGAENVPDE-PCVILSNHQSTWETFFLSQ--YFSPLSQV---LKRELL-YVPFFGWamamLRPIAI 129
Cdd:cd06551    3 YLLLNFFGFVRLEVKGPPPPPGGgPVLFVSNHSSWWDGLILFLllERGLRRDVyglMDEELLeRYPFFTR----LGAFSV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 130 NRDNPKEAlRQVASKGDELLKQ-KTWVLIFPEGTRVPFGTMGK-FSRGGTALAVNAGLPVLPIAHNaGKFWPKTGWgkra 207
Cdd:cd06551   79 DRDSPRSA-AKSLKYVARLLSKpGSVVWIFPEGTRTRRDKRPLqFKPGVAHLAEKAGVPIVPVALR-YTFELFEQF---- 152

                        170
                 ....*....|
gi 644586095 208 GTIEVVIGEP 217
Cdd:cd06551  153 PEIFVRIGPP 162
PRK14014 PRK14014
putative acyltransferase; Provisional
 6-123 2.66e-11

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 62.56  E-value: 2.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095   6 MSILQAIRIFLFYLLLGTSSLLWCSLSFFVAPF---LSFPK-RYK------FINVYWCRCALFLVRTILGIDYKITGAEN 75
Cdd:PRK14014   3 NFLLAPLRGLLSILLLILNTLFWSVPIIILGLLkllLPIPAiRRAcsrllnFIAEAWISINNVILRLLPRTQWDVEGLEG 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 644586095  76 V-PDEPCVILSNHQStWETFFLSQYFS----PLSQV-LKRELLYVPFFG---WAMAM 123
Cdd:PRK14014  83 LsKKGWYLVISNHQS-WVDILVLQYVFnrriPMLKFfLKQELIWVPFLGlawWALDF 138
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 82-190 5.69e-09

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 55.02  E-value: 5.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  82 VILSNHQSTWETFFLSQYFSPLS-QVLKRELLYVPFFGWAMAMLRPIAINRDNPKEALRQVASKGDELLKQKTWVLIFPE 160
Cdd:PRK15018  68 IYIANHQNNYDMVTASNIVQPPTvTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPE 147

                         90       100       110
                 ....*....|....*....|....*....|
gi 644586095 161 GTRVPFGTMGKFSRGGTALAVNAGLPVLPI 190
Cdd:PRK15018 148 GTRSRGRGLLPFKTGAFHAAIAAGVPIIPV 177
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 57-244 6.00e-09

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 56.47  E-value: 6.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095   57 LFLVRTILGIDYKIT--GAENVPDE-PCVILSNHQStWETFFLSQYFSP--LSQVLKRELLYVPFFGWAMAMLRPIAINR 131
Cdd:PRK08633  416 RFLLLLLMHTRYRLRveGRENIPAKgGALLLGNHVS-WIDWALLQAASPrpIRFVMERSIYEKWYLKWFFKLFGVIPISS 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  132 DNPKEALRQVAskgdELLKQKTWVLIFPEGTRVPFGTMGKFsRGGTALAV-NAGLPVLPI----------AHNAGKFwpK 200
Cdd:PRK08633  495 GGSKESLEFIR----KALDDGEVVCIFPEGAITRNGQLNEF-KRGFELIVkGTDVPIIPFyirglwgsifSRASGKF--L 567

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 644586095  201 TGWGKRAG-TIEVVIGEPMYANGTG---PRAIAELNdrAAAWNEATQR 244
Cdd:PRK08633  568 WRWPTRIPyPVTVAFGKPMPAHSTAhevKQAVFELS--FDSWKSRKEA 613
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 69-222 4.75e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 48.37  E-value: 4.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  69 KITGAenVPDEP--CVILSNHQSTWETF-FLSQYFS---PLSQVLKRELLYVPFfGWAMAMLRPIAINRDNPKEALRQVA 142
Cdd:cd07988   11 RIEGE--PPNKPkfVVIGAPHTSNWDFVlGLLAAFAlglKISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAGGLVEQVV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 143 skgDELLKQKT-WVLIFPEGTRvpfGTMGKFSRGGTALAVNAGLPVLPIAHNagkfwpktgWGKRagtiEVVIGEPMYAN 221
Cdd:cd07988   88 ---EEFRRREEfVLAIAPEGTR---SKVDKWKTGFYHIARGAGVPILLVYLD---------YKRK----TVGIGPLFEPS 148


                 .
gi 644586095 222 G 222
Cdd:cd07988  149 G 149
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 58-223 4.01e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 43.40  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  58 FLVRTILGIDYK---ITGAENVPDE-PCVILSNHQSTwetFF-----LSQYFSPLSQVLKRELLYVPFFGWAMAMLRPIA 128
Cdd:cd07992    3 LLSRVILRIYFRritVVGRENVPKDgPVIFLGNHPNA---LIdplllAATLRRPVRFLAKADLFKNPLIGWLLESFGAIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 129 INRDNPKEALRQVASKGD-------ELLKQKTWVLIFPEGTRVPFGTMGKFSRG------GTALAVNAGLPVLPIAHNAG 195
Cdd:cd07992   80 VYRPKDLARGGIGKISNAavfdavgEALKAGGAIGIFPEGGSHDRPRLLPLKAGaarmalEALEAGQKDVKIVPVGLNYE 159

                        170       180
                 ....*....|....*....|....*...
gi 644586095 196 KfwpKTGWGKRAgtiEVVIGEPMYANGT 223
Cdd:cd07992  160 D---KSRFRSRV---LVEFGKPISVSAF 181
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 34-188 2.66e-04

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 41.61  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  34 FVAPFLSFPKRykFINVYWCRCAL------------FLVRTILGIDYKITGaENVPDEPCVIL-SNHQST------WETF 94
Cdd:PLN02510  37 YLAPVSAVLLR--LFSVHYSRKATsfffgswlalwpFLFEKINKTKVVFSG-DKVPPEERVLLiANHRTEvdwmylWDLA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  95 FLSQYFSPLSQVLKRELLYVPFFGWAMAMLRPIAINR----DNPkeALRQVAS----KGDELlkqktWVLIFPEGTRVpf 166
Cdd:PLN02510 114 LRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERkwevDEP--NIRQMLSsfkdPRDPL-----WLALFPEGTDY-- 184

                        170       180
                 ....*....|....*....|..
gi 644586095 167 gTMGKFSRgGTALAVNAGLPVL 188
Cdd:PLN02510 185 -TEAKCQR-SQKFAAEHGLPIL 204
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
 133-219 2.54e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 37.96  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095 133 NPKEALRQVAskgdELLKQKTWVLIFPEGTRvpfGTMGKFSRGGTALAVNAGLPVLPIAHNAGKFWPKTGWGKRA----- 207
Cdd:cd07983   82 GGAAALREML----RALKDGYNIAITPDGPR---GPRYKVKPGVILLARKSGAPIVPVAIAASRAWRLKSWDRFIipkpf 154

                         90
                 ....*....|..
gi 644586095 208 GTIEVVIGEPMY 219
Cdd:cd07983  155 SRVVIVFGEPIH 166
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 69-192 8.54e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 36.42  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644586095  69 KITGAENVPDE-----PCVILSNHQSTWE--TFFLSQYFSPLSQVLKRelLYVPFFGWAMAMLRP----IAINRDNpkeA 137
Cdd:cd07984    5 EREGLEHLEAAlakgkGVILLTAHFGNWElaGLALALLGYPVTVVYRP--LKNPLLDRLITRGRErfgaRLIPRGG---G 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 644586095 138 LRQVASkgdeLLKQKTWVLIFP-------EGTRVPF-GTMGKFSRGGTALAVNAGLPVLPIAH 192
Cdd:cd07984   80 LRELIR----ALKKGEIVGILPdqdpgrkGGVFVPFfGRPAATPTGPARLALKTGAPVVPAFA 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH