|
Name |
Accession |
Description |
Interval |
E-value |
| actP |
PRK09395 |
cation/acetate symporter ActP; |
1-550 |
0e+00 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 999.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 1 MKRLLSAAALLLLPGLACADAIGGEVHRQPLNIQAIVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIA 80
Cdd:PRK09395 2 MKRLLTALAALLPAAAAAADAISGEVEKQPTNWQAIIMFLIFVVFTLGITYWAAKRTRSASDFYTAGGGITGFQNGLAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 81 GDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVAL 160
Cdd:PRK09395 82 GDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQGPIRTLSACGSLVVVAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 161 YLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAE 240
Cdd:PRK09395 162 YLIAQMVGAGKLIQLLFGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFMAFMVMKHVGFSFENLFSE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 241 AVKVHPKGIAIMSPGGLVSDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAI 320
Cdd:PRK09395 242 AVAVHPKGLAIMGPGGLVKDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAI 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 321 LLVSANPAFKDATGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNGKATER 400
Cdd:PRK09395 322 VLVGTNPEFKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKGKATER 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 401 DELKVSKITVVVLGLVAIALGILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILG 480
Cdd:PRK09395 402 DELRVSKITTLVLGVVAIILGILFEKQNIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVVLMILS 481
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 481 PTIWVQILGHEKPIYPYEYPALFSMIVAFVGTWLFSITDSSLAGQQERERFRAQFVRSQTGLGISQGSSH 550
Cdd:PRK09395 482 PTVWVDILGHEKAIFPYEYPALFSMPLAFVGIWFFSITDNSARAKREREAFRAQFVRSQTGIGASGASAH 551
|
|
| symport_actP |
TIGR02711 |
cation/acetate symporter ActP; Members of this family belong to the Sodium:solute symporter ... |
20-550 |
0e+00 |
|
cation/acetate symporter ActP; Members of this family belong to the Sodium:solute symporter family. Both members of this family and other close homologs tend to be encoded next to a member of pfam04341, a set of uncharacterized membrane proteins. The characterized member from E. coli is encoded near and cotranscribed with the acetyl coenzyme A synthetase (acs) gene. Proximity to an acs gene was used as one criterion for determining the trusted cutoff for this model. Closely related proteins may differ in function and are excluded by the high cutoffs of this model; members of the family of phenylacetic acid transporter PhaJ can score as high as 1011 bits. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 131758 Cd Length: 549 Bit Score: 925.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 20 DAIGGEVHRQPLNIQAIVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTS 99
Cdd:TIGR02711 19 DAISGAVERQPLNIQAIIMFLLFVGFTLYITYWASKKTRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVYTS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 100 GYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGL 179
Cdd:TIGR02711 99 GYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQRPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 180 NYHVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPKGIAIMSPGGLVS 259
Cdd:TIGR02711 179 NYHVAVVLVGILMVMYVLFGGMLATTWVQIIKAVLLLFGATFMAFMVMKSVGFSFNTLFKEAMAVHPKGVAIMSPGGLVS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 260 DPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKDATGALLGG 339
Cdd:TIGR02711 259 DPISALSLGLGLMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFMGYFYILTFIIGFGAILLVSANPEFKDATGALIGG 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 340 TNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNGKATERDELKVSKITVVVLGLVAIA 419
Cdd:TIGR02711 339 NNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKGKATERDELRVSKITVLILGVIAIG 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 420 LGILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHEKPIYPYEY 499
Cdd:TIGR02711 419 LGILFENQNIAFMVGLAFSIAASCNFPIILLSMYWSKLTTRGAMIGGWLGLITAVVLMILGPTIWVQILGHEKPIYPYEY 498
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 644369059 500 PALFSMIVAFVGTWLFSITDSSLAGQQERERFRAQFVRSQTGLGISQGSSH 550
Cdd:TIGR02711 499 PALFSMIVAFIGIWFFSITDNSETGAQERELFRAQFIRSQTGLGASQGRAH 549
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
21-550 |
0e+00 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 749.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 21 AIGGEVHRQPLNIQAIVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSG 100
Cdd:PRK12488 20 PALDAGQRQPLNWTAIGMFMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 101 YDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLN 180
Cdd:PRK12488 100 YDGLLYALGVLAGWPIILFLIAERLRNLGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLMYLVAQMVGAGKLIELLFGIS 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 181 YHVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPKGIAIMSPGGLVSD 260
Cdd:PRK12488 180 YLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASAVAVHAKGQAILAPGGLLSN 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 261 PISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKDATGALLGGT 340
Cdd:PRK12488 260 PIDAISLGLGMMFGTAGLPHILMRFFTVSDAREARKSVLYATGFIGYFYLLIIVVGFGAIVMVGTEPSYRDAGGKIIGGG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 341 NMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNGKATERDELKVSKITVVVLGLVAIAL 420
Cdd:PRK12488 340 NMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKGQASEAQEMRVSKIATLGIGLLAVVL 419
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 421 GILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHEKPIYPYEYP 500
Cdd:PRK12488 420 GLMFESQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLVSAVVLVVLGPAVWVNVLHNATALFPYSNP 499
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 644369059 501 ALFSMIVAFVGTWLFSITDSSLAGQQERERFRAQFVRSQTGLGISQGSSH 550
Cdd:PRK12488 500 ALFSMSLAFLSAWVFSVTDRSERAVAERGRYLAQFVRSMTGIGAAGASKH 549
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
24-548 |
0e+00 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 720.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 24 GEVHRQPLNIQAIVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDG 103
Cdd:COG4147 3 ALLEQLGMNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 104 LIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHV 183
Cdd:COG4147 83 LIYSIGWLVGYVLLLLLLAEYLRNFGKFTVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYEV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 184 AVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPKGIAIMSPGGLVSDPIS 263
Cdd:COG4147 163 AVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLPLLAKAAEVHDLGAAYLEPGGLVKSPLD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 264 ALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKDAT--GALLGGTN 341
Cdd:COG4147 243 FISLGLALMLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALVGPLPEWFDTGliGAADGGGN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 342 MAAVHLANAV-GGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKnGKATERDELKVSKITVVVLGLVAIAL 420
Cdd:COG4147 323 MAVLALAEIAgGGNWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANVIK-GKATEKEELRVARIAAVVIGVVAILL 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 421 GILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVqiLGHEKPIYPYEYP 500
Cdd:COG4147 402 GINAPPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALVLIVLSPFVWV--LGVDAALFPLENP 479
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 644369059 501 ALFSMIVAFVGTWLFSITDSSLAgQQERERFRAQFVRSQTGLGISQGS 548
Cdd:COG4147 480 GLVSMPLGFLVAIVVSLLTPEPP-AEDQELVEEQEVRSPTGIGAAKAS 526
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
36-518 |
0e+00 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 579.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLY 195
Cdd:cd11480 81 LLLLLVAEPLRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 196 VLFGGMLATTWVQIIKAVLLLAGASFMALMVM-----KSVNFDFNTLFAEAVKVHPKGIAIMSPGGLVSDPISALSLGLA 270
Cdd:cd11480 161 VVLGGMRATTWVQIIQYVLLLGAFLVPAILVLarfggNPLGAGPGLLGLAAAAASGAGEAYLAPGLLLTDPLDVISLTLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 271 LMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKDATGALLGGTNMAAVHLANA 350
Cdd:cd11480 241 LMLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDGGGDMAVLLLPEI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 351 VG-GNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNGkATERDELKVSKITVVVLGLVAIALGILFEKQNI 429
Cdd:cd11480 321 AGlGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPG-ASERREVRVARIAAVVVGVIAILLALLFPPQNV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 430 AFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHEKPIYPYEYPALFSMIVAF 509
Cdd:cd11480 400 AFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLSPAVSGAPPGHDFAGFPLTNPGLVSVPLGF 479
|
....*....
gi 644369059 510 VGTWLFSIT 518
Cdd:cd11480 480 LVAIVVSLL 488
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
63-469 |
1.57e-130 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 386.69 E-value: 1.57e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 63 YYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQ 142
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 143 QKPI-RTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASF 221
Cdd:pfam00474 81 GKRIlVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 222 MALMVMKSVNfDFNTLFAEAVKVHPKGIAIMSPGGL--VSDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVF 299
Cdd:pfam00474 161 LMIIVFHEVG-GYSSAVEKYMTADPNGVDLYTPDGLhiLRDPLTGLSLWPGLVLGTTGLPHILQRCLAAKDAKCIRCGVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 300 YATGFIGYFYILTFIIGFGAILLVSANPafkDATGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAG 379
Cdd:pfam00474 240 ILTPMFIIVMPGMISRGLFAIALAGANP---RACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 380 ASAVSHDLYASVMKNGKATERDELKVSKITVVVLGLVAIALGILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTT 459
Cdd:pfam00474 317 SSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAFLPVILLAIFWKRVNE 396
|
410
....*....|
gi 644369059 460 RGAMIGGWLG 469
Cdd:pfam00474 397 QGALWGMIIG 406
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
31-514 |
6.22e-72 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 237.41 E-value: 6.22e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 31 LNIQAIVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGF 110
Cdd:COG0591 1 MSTLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 111 LIGWPIILFLIAERLRNLGRYTFADVASYRLqQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGI 190
Cdd:COG0591 81 ALGALLLALFFAPRLRRLGALTIPEFLEKRF-GRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 191 LMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNfDFNTLFAeavKVHPKGIAIMSPGGLVSDPISALSLGLA 270
Cdd:COG0591 160 IVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG-GFGELFA---ALPAPGLLSLFPGLGFTGWLAFLGLFLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 271 LMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKdatgallggTNMAAVHLANA 350
Cdd:COG0591 236 IGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPLAD---------PDLALPLLILE 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 351 VGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYaSVMKNGKATERDELKVSKITVVVLGLVAIALGILFeKQNIA 430
Cdd:COG0591 307 LLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIY-KPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLF-PSSIL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 431 FMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTiwvqiLGHEKPIYPYEYPALFSMIVAFV 510
Cdd:COG0591 385 DLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGP-----LGPFGWLYPILPGLLVSLLVFVV 459
|
....
gi 644369059 511 GTWL 514
Cdd:COG0591 460 VSLL 463
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
40-516 |
1.70e-68 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 230.60 E-value: 1.70e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 40 ILFVGAT--LYIT--YWAskRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:TIGR03648 2 YLFVGATfaLYIGigIWS--RAGSTSEFYVAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYDGLAYLMGWTGGYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLY 195
Cdd:TIGR03648 80 LLALLLAPYLRKFGKYTVPDFIGDRYYSNTARLVAVICAIFISFTYVAGQMRGVGVVFSRFLEVDFETGVFIGMAIVFFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 196 VLFGGMLATTWVQIIKAVLL----LAGASFMALMVmkSVNFDFNTLFAEAVKVHPK-----------GIAIMSPGGLVSD 260
Cdd:TIGR03648 160 AVLGGMKGVTWTQVAQYIVLivayLVPAIFISLKL--TGNPVPQLGYGSALSGVYLldkldelevdlGFAEYTEPFGSKS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 261 PISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFY-------------ILTFIIGFG--------- 318
Cdd:TIGR03648 238 RINVFALTLALMVGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYttapavaafarynLITTVNGTPyaelpgwva 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 319 ---AILLVSANPAFKDATGALLGGT------NMAAVHLANAVGGN---FFLGFISAVAFATILAVVAGLTLAGASAVSHD 386
Cdd:TIGR03648 318 nweKTGLLKFEDKNGDGILQYSGDAgneltiDRDIIVLATPEIAGlpyWVIGLVAAGGLAAALSTAAGLLLVISSAISHD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 387 LYASVMkNGKATERDELKVSKITVVVLGLVAIALGILfEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGG 466
Cdd:TIGR03648 398 LYYRII-NPNASEKQRLLVARIALVVAAVIAGYFGLN-PPGFIAQVVAFAFGLAAASFFPALVLGIFWKRMNREGAIAGM 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 644369059 467 WLGLLTAVILMIL-GPTIWVQILGHEKPIYPY------EYPALFSMIVAFVGTWLFS 516
Cdd:TIGR03648 476 LTGLGFTFSYIVYfKPWGFIGTNPGANVPENWwfgispEGIGLIGMPVNFAVAIVVS 532
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
36-516 |
1.02e-63 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 215.11 E-value: 1.02e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLY 195
Cdd:cd10322 83 LLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 196 VLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPKGIAIMSPGGlvsdPISALSLGLALMFGT 275
Cdd:cd10322 163 TVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLG----WSTILSLILLTGLGV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 276 AGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSAnpafkdatgalLGGTNMAAVHLANAVGGNF 355
Cdd:cd10322 239 LALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPD-----------LENPDLALPTLINSLLPPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 356 FLGFISAVAFATILAVVAGLTLAGASAVSHDLYAsVMKNGKATERDELKVSKITVVVLGLVAIALGILFekQNIAFMVGL 435
Cdd:cd10322 308 LAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYK-PLINPKASDKKLLRVSRIAVVVVGVLALLLALLP--PSILLLLSL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 436 AFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQIlghekpiypyeYPALFSMIVAFVGTWLF 515
Cdd:cd10322 385 AAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPLGI-----------DPIIPALLVSLIVFVVV 453
|
.
gi 644369059 516 S 516
Cdd:cd10322 454 S 454
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
36-517 |
3.28e-61 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 208.90 E-value: 3.28e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNL----GRYTFADVASYRLQQKP--IRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVG 189
Cdd:cd11475 81 LNWLFVAKRLRRYteknDSITLPDYLENRFRDKSklLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 190 ILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNfDFNTLFAEAVKVHPKGIAIMsPGGLVSDPISALSLGL 269
Cdd:cd11475 161 VVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALG-GLSGLVAALAAIDPGLLSPF-GGDLGAGGLLAIISLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 270 ALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVsanpafkdaTGALLGGTNMAAVHLAN 349
Cdd:cd11475 239 AWGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALF---------PDGLLGDPETVFPVLAQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 350 AVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKnGKATERDELKVSKITVVVLGLVAIALGiLFEKQNI 429
Cdd:cd11475 310 ELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLR-KEASDKELVWVSRLAVLVIALIALLIA-LNPPSSV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 430 AFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTI-WVqilghekpiypyeYPALFSMIVA 508
Cdd:cd11475 388 FSLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLGLGIfGL-------------YEIVPGFLAS 454
|
....*....
gi 644369059 509 FVGTWLFSI 517
Cdd:cd11475 455 LLAIVVVSL 463
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
66-465 |
8.99e-52 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 182.12 E-value: 8.99e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 66 AGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQKP 145
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 146 IRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGasFMALM 225
Cdd:TIGR00813 81 LRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILG--TFILP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 226 VMKSVNFDFNTLFAEAVKVHPKgiAIMSPGGLVSDPISALSLGLALMFGTAGLPH----------ILMRFFTVSDAKEAR 295
Cdd:TIGR00813 159 VFAFSEVGGLGTFVEKASQAAP--TNPSPDDLYDFFRDPSTSDLPWGAGVFGLPHvalwywtnqvIVQRCLAAKSAKHAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 296 KSVFYATGFIGYFYILTFIIGFGAILLVSAnpAFKDATGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGL 375
Cdd:TIGR00813 237 KGCLISGVLKLLPMFGAVLPGLIARALYTD--IDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQ 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 376 TLAGASAVSHDLYASVMKNGKATERDELKVSKITVVVLGLVAIALgILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWS 455
Cdd:TIGR00813 315 LNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGFV-AAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWK 393
|
410
....*....|
gi 644369059 456 RLTTRGAMIG 465
Cdd:TIGR00813 394 RMNAKGALAG 403
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
36-521 |
2.61e-29 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 121.15 E-value: 2.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRT-RSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGW 114
Cdd:cd11477 3 WLVIALYFLLMLGIGLWFSKRAsKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 115 PIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLS----ACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGI 190
Cdd:cd11477 83 LIGAFVFARRWRRLRVLTDGEFPEERYGGRYGAPLRqfyaVYFALLSNVDILAWVFLAAIKVSAVFGPWDPWLTILILGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 191 LMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFD---FNTLFAEAVKVHPKGIAIMSPGGLVSdpISALSL 267
Cdd:cd11477 163 ITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPgglFAQLPEGHLDLFGSGLGASGFYITFF--FILFFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 268 GLALMFGTAGlPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSanpafkdATGALLGGTNMAAVHL 347
Cdd:cd11477 241 WYPLSYSGGG-WYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYP-------DLDDPEADFELAYPMM 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 348 ANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNgKATERDELKVSKITVVVLGLVAIALGilFEKQ 427
Cdd:cd11477 313 IKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKP-NASEKHLLKVGRLATVLFGLLSIVVA--LASD 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 428 NIAFMVGLAFSIAASCNFPiIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQILghekPIYPYEYPALFSMIV 507
Cdd:cd11477 390 SIGGAFWIVLALGAGLGGP-LILPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVFGLPED----FLFSFLVPVLLSLVV 464
|
490
....*....|....
gi 644369059 508 AFVGTWLFSITDSS 521
Cdd:cd11477 465 WLAVTLLTPPTDEE 478
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
36-475 |
2.41e-25 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 109.34 E-value: 2.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:PRK15419 8 LVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLR-----NLGRYTFADVASYRLQQKP--IRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILV 188
Cdd:PRK15419 88 INWKLVAGRLRvhteyNNNALTLPDYFTGRFEDKSriLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 189 GILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLfaEAVKVHPKGIAIMSPGGLVSDPISALSLG 268
Cdd:PRK15419 168 AAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSL--EVIKQKSIENVDMLKGLNFVAIISLMGWG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 269 LalmfGTAGLPHILMRFFtvsdAKEARKSVFYATGFIGYFYILTF----IIGFGAILLVSANPAFkdaTGALLGGTNMAA 344
Cdd:PRK15419 246 L----GYFGQPHILARFM----AADSHHSIVHARRISMTWMILCLagavAVGFFGIAYFNEHPAV---AGAVNQNAERVF 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 345 VHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNGkATERDELKVSKITVVVLGLVAIALGILF 424
Cdd:PRK15419 315 IELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKH-ASQKELVWVGRVMVLVVALVAIALAANP 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 644369059 425 EKQNIAfMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVI 475
Cdd:PRK15419 394 ENRVLG-LVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIV 443
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
36-516 |
3.10e-25 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 108.77 E-value: 3.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLI-----YSIGF 110
Cdd:cd11474 1 LIGVILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAqdpfgYALCL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 111 LIGWpiilFLIAERLRNLGRYTFADVasyrLQQKPIRTLSACGSLVVVALYLI---AQMVGAGKLIQLLFGLNYHVAVIL 187
Cdd:cd11474 81 ILGG----LFFAKPMRRMGLLTLGDF----FRQRYGRRVEVLLSIPAVLSYLGwvaAQLVALGLVLSVILGLPVETGILI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 188 VGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFdfntlFAEAVKVHPKGIAIMSPGGLVSDPISALSL 267
Cdd:cd11474 153 SAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGG-----VDIASAAAAGKLRFFPWLGTKSDWLIWIDA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 268 GLALMFGtaGLPHILM--RFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKDATGALLGGTNMAAV 345
Cdd:cd11474 228 WLTLGLG--SIPQQDVfqRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEEDAQLILPLLLQY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 346 HLANAVGGNFFLGFISAvafatILAVVAGLTLAGASAVSHDLYASVMKNgKATERDELKVSKITVVVLGlvAIALGILFE 425
Cdd:cd11474 306 LTPLWVQVLFLGALLSA-----VMSTADSALLAPSSVFSENIYKPPFRP-KASDRELLWVMRISVVVFG--AIATLMALT 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 426 KQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQIlghekPIYPYEYPA-LFS 504
Cdd:cd11474 378 VESIYGLVELASDLVLVGLFVPLLAGLYWKRANTYGALAAIIVGLVLRLLGGELLLGLPADI-----PPQLQGFPFsTLA 452
|
490
....*....|..
gi 644369059 505 MIVAFVGTWLFS 516
Cdd:cd11474 453 MVIGSLLPLAVS 464
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
36-484 |
3.52e-22 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 99.59 E-value: 3.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSR-----QDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYD-GLIYSIG 109
Cdd:cd10327 2 LLPIIIYLVILLGIGFYARRSKKRRsgdflEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGwVLLAMIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 110 FLIGWpIILFLIAERLRNLGRYTFA----DVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAV 185
Cdd:cd10327 82 VPTGF-LTLGVLGKKFAIIARKINAvtiiDYLRARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 186 ILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNfDFNTLFAEAVKVHPKgiAIMSPGGLVSDPISAL 265
Cdd:cd10327 161 LIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGG-GMEAIMATLAEIDPN--LLTPFGPGFLSPPYIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 266 SLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSaNPAFKDATGALLggtnmaAV 345
Cdd:cd10327 238 SFWVLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLP-DLEVPDKVIPTL------AL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 346 HLANavggNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYA-SVMKNGKATERDELKVSKITVVVLGLVAIALGIlf 424
Cdd:cd10327 311 KVLP----PWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLnYKNKEKKTSEKKVKRISLIITIILGLLVFLLAI-- 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 644369059 425 ekQNIAFMVGL---AFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIW 484
Cdd:cd10327 385 --NPPDLIVWLnlfAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIKIL 445
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
36-479 |
4.28e-21 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 96.13 E-value: 4.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRItglqnGLAIAGDFMSA-----ASFLGISALVYTSGYDG--LIYSI 108
Cdd:cd11479 3 YGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRL-----GPGLYLGTMAAvvlggASTIGGVGLGYQYGISGmwLVVAI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 109 GFliGWPIILFLIAERLRNLGRYTFADVASYRLQQKPiRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILV 188
Cdd:cd11479 78 GL--GILALSLLLAKRIARLKVYTVSEVLELRYGPSA-RVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 189 GILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHpkgiaiMSPGGLVSDPISA--LS 266
Cdd:cd11479 155 GGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPLALSKAGGLSGLQEKLPASY------FDLTSIGWDTIVTyfLL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 267 LGLALMFGTaglpHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSAnpafkdatgalLGGTNMAAVH 346
Cdd:cd11479 229 YFFGILIGQ----DIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLPD-----------LANPQNAFAT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 347 LANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMkNGKATERDELKVSKITVVVLGLVAIALGILFek 426
Cdd:cd11479 294 MAQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLR-RKNESERSEVRLSRLFTLLLGVVVIVIAVLV-- 370
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 644369059 427 QNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMIL 479
Cdd:cd11479 371 NDVVAALTIAYAILVGGLLVPILGGLFWKRATGAGALASMVAGSVVVLAGMAV 423
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
35-475 |
2.97e-20 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 93.81 E-value: 2.97e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 35 AIVMFILFVGATLYITYWASKRTRSRQ--DYYTAGGRITGLqnGLAIAGDFMS---AASFLGISALVYTSGYDGLI-YSI 108
Cdd:cd11476 4 VIGLGALFALLMVFITRLLKRYRGKNQssEEFMTAGRSVGT--GLTAAAIVSSwtwAATLLQSATVAYQYGVSGPFwYAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 109 GFLIgwPIILF-LIAERLRNL--GRYTFADVASYRLQQKPIRTLSACgSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAV 185
Cdd:cd11476 82 GATL--QILLFaPLAIRIKRLapNAHTLLEIVRARYGTAAHLVFLVF-ALFTNVIVLAMLLLGGSAVVNALTGMPIVAAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 186 ILVGILMVLYVLFGGMLAT---TWVQIIKAVLLLAGASFMALMVMKSVNFD-FNTLFAEAVKVHPKGIAIMSPGGLVSdp 261
Cdd:cd11476 159 FLIPLGVLLYTLFGGLRATfltDYIHTVIILIILLVFAFAVYTSSDIGSPSkVYDLLQEAAPDLPVEGNQGSYLTFKS-- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 262 ISALSLGLALMFGTAGL----PHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLvSANPAFKDatgall 337
Cdd:cd11476 237 KAGLIFGIINIVGNFGTvfldQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALAL-GLNPTFEE------ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 338 GGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASvMKNGKATERDELKVSKITVVVLGLVA 417
Cdd:cd11476 310 VSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRT-YINPNATGKQLLRVSRIAVIGFGLFM 388
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 418 IALGILFEKQ--NIAFMVGLAFSIAASCNFPiIILSMYWSRLTTRGAMIGGWLGLLTAVI 475
Cdd:cd11476 389 GGLAVGLNYIgiSLGWLLLFMGILIGSAVFP-VALGLYWRRQTGTAAVVSPIAGLVAGLA 447
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
37-484 |
1.54e-19 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 91.45 E-value: 1.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 37 VMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWPI 116
Cdd:cd11495 7 LVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSIIIAAPL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 117 ILFLIAERLRNLGRYTfadvASYRLQQKPIRTLSACGSLVVVaLYLIAQMVGAGKL----IQLLFGLNYHVAVILVGILM 192
Cdd:cd11495 87 AAYFFVPFFRRLNVTS----AYEYLEKRFGPWARVYGSLLFI-LFQLGRMGIVLYLpalaLSAVTGINPYIIIILMGVLC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 193 VLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPkgiaiMSPGGLVSDpISALSLGLALM 272
Cdd:cd11495 162 IIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPGGFGEVFDIAIANGK-----FSLGDFSFS-LTESTIWVIFI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 273 FGTA-------GLPHILMRFFTVSDAKEARKSVFyaTGFIGYFYILTFIIGFGAILLV--SANPAFKDATGAllgGTNMA 343
Cdd:cd11495 236 GGIFnnlqsytSDQDVVQRYLTTKSIKEAKKSLW--TNALLALPVALLFFGIGTALYVfyQQHPELLPAGIN---GDAVF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 344 AVHLANA--VGgnfFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNgkATERDELKVSKITVVVLGLVAIALG 421
Cdd:cd11495 311 PYFIVTQlpVG---VAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPD--PSDKQYLKVARLITLLVGLLGTLVA 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 644369059 422 ILFEKQNIAFMVGLAFSIAASCNFPII---ILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIW 484
Cdd:cd11495 386 LYLANAGVKSLLDAFNTLTGLFGGGLAglfLLGIFTKRANAKGALVGIIVSIIVIFWISLLYTPIH 451
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
40-518 |
6.06e-19 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 89.65 E-value: 6.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 40 ILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSG-------YDGLIYSIGFLi 112
Cdd:cd11478 7 AVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGiatvhfyWIGAIPAMVFL- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 113 GWPIILFLIAERLRNLGRYTfadvaSYRLQqKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILM 192
Cdd:cd11478 86 GIVMMPFYYGSKVRSVPEYL-----KLRFN-KSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 193 VLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNfDFNTLFAEAVKVHPKGIAIMSPGGLVSDPISALSLGLALM 272
Cdd:cd11478 160 LAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVG-GWDGLSEKIDANGPPGWNGLSWGPQGSQSTNPMGVNLGLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 273 FgtaGLPHIL------------MRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVSANPAFKDATGallggt 340
Cdd:cd11478 239 F---GLGFVLsfgywttnflevQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGLDY------ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 341 NMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNGKaTERDELKVSKITVVVLGLVAIAL 420
Cdd:cd11478 310 NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDA-PDKHYLKVGRIATVVGVLISIGT 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 421 G-ILFEKQNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQILGHEKPIYpyeY 499
Cdd:cd11478 389 AyIASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELGLIVYHSDMAPNF---Y 465
|
490
....*....|....*....
gi 644369059 500 PALFSMIVAFVGTWLFSIT 518
Cdd:cd11478 466 GAWWAFVVCFVVTVLVSLL 484
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
36-483 |
5.96e-17 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 83.42 E-value: 5.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGaTLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:cd11494 4 IVLVGYLLG-ILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPLAMI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNLGRYTFADVASYRLQQKpIRTLSAcgslvvvALYLIAQMVGAGKLI-------QLLFGLNYHVAVILV 188
Cdd:cd11494 83 FLCITFVPVFYKLKVYTAYEYLERRFGLK-TRLLTS-------ILFLISRGLATGVTIyapaiilSTILGWSLWLTILLI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 189 GILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPKGIAIMSPGGLVSDPISALSLG 268
Cdd:cd11494 155 GGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGKSGRLNALDFSFDLSDTYTFWSGLIG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 269 LALM----FGTAGLphILMRFFTVSDAKEARKSVFyATGFIG---YFYILTFIIGFGAILLVSANPAFKDATGALLGGTN 341
Cdd:cd11494 235 GFFLylsyFGTDQS--QVQRYLTAKSIKEARKSLL-LNGFLKfpmQFFILLIGVLVFVFYQFNPFPVSFNPAEDETKDTN 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 342 MAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYAsVMKNGKATERDELKVSKITVVVLGLVAIALG 421
Cdd:cd11494 312 YIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYR-RFFKKDASDEHYLKVSRLLTVFWGLLAIVFA 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 644369059 422 ILFEK-QNIAFMVGLAFSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLtAVILMILGPTI 483
Cdd:cd11494 391 LFAGLaGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVI-VVIVLWLFPDV 452
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
36-483 |
2.32e-13 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 72.21 E-value: 2.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:cd10326 2 WAVVVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNLGRYTfadVASYrLQQKPIRTLSACGSLvvvaLYLIAQMVGAGKLI--------QLLF---GLNYHVA 184
Cdd:cd10326 82 IIAFVLLPLYYRLNLTS---IYEY-LEDRFGVSSRKTGAV----FFLLSRILGAGIRLylvalvlqQFLFdslGIPFWLT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 185 VILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHpkgiaiMSPGGLVSDPISA 264
Cdd:cd10326 154 VLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAISAAGESG------YSRIFNFDDDNSR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 265 LSLGLALMFG------TAGLPHILM-RFFTVSDAKEARKSVFYaTGFIGYFYILTF-IIGFGAILLVSANPAFKDATGAL 336
Cdd:cd10326 228 RTFWKQFLGGifitiaMTGLDQDMMqRNLSCKNLKDAQKNMLT-FGVILVPVNLLFlLLGVLLYTYAQKNGIALPAKDSD 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 337 LGGTNMAAVHLANAVGGNFFLGFISAvAFATILAVVAGLTlagaSAVSHDLY-ASVMKNGKATERDELKVSKITVVVLGL 415
Cdd:cd10326 307 QLFPYFALNGLPPGVSGLFVAGIIAA-AMSSADSALTALT----TSFCVDILnRFKRKSEKKSERKYVHIAFSLTFVLGI 381
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 416 VAIALGIlfekqNIAFMVGLAFSIAASCNFPIIILSMY--WSRLTTRGAmIGGWLGLLTAVILMILGPTI 483
Cdd:cd10326 382 LVFGSAS-----NSGSLIDAIFKVAGYTYGPLLGLFAFglFTKRAVKDK-WVPLVGLLAPVLSYLLVSNS 445
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
35-480 |
4.52e-11 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 65.29 E-value: 4.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 35 AIVMFILFVGATLYITYWASKR--TRSRQDYYTAGGRITGLqnglAIAGDFM----SAASFLGISALVYTSGYDGLIYSI 108
Cdd:PRK10484 3 TILSFLGFTLLVAVISWWKTRKtdTSSSDGYFLAGRSLTGP----VIAGSLLltnlSTEQLVGLNGQAYASGMSVMAWEV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 109 GFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSAC---GSLVV---VALYLIAQMVGAGKLIQLLFGLNYH 182
Cdd:PRK10484 79 TAAIALIILALIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILfliGYVVSflpIVLYSGALALNSLFHVSELLGISYG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 183 VA----VILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGA---SFMALMVMKSVNF--DFNTLFAeavkVHP-KGIAIM 252
Cdd:PRK10484 159 AAiwllVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGllvPVFGLIALGDGSFmqGLEQLTT----VHPeKLNSIG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 253 SPGGLVsdPISALSLGLAL--MFGTAGLPHILMRFFTVSDAKEARKSVFYAtgfiGYFYILTFII----GFGAILLVsan 326
Cdd:PRK10484 235 GATDPV--PFPTLFTGLILvnLFYWCTNQSIVQRALGAKNLAEGQKGALLA----AFFKLLGPLIlvlpGIIAFHLY--- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 327 pafkdatGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNgKATERDELKVS 406
Cdd:PRK10484 306 -------GDGLPNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINP-NASEKQLVKVG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 407 KITVVVLGLVAIALGILfekqnIAFMVGLAFSIAASCN-------FPIIILSMYWSRLTTRGAMIggwlGLLTAVILMIL 479
Cdd:PRK10484 378 KKFGFVLAIISMIVAPL-----IANAPQGLYSYLQQLNgiynvpiLAIIIVGFFTKRVPALAAKV----ALGFGIILYII 448
|
.
gi 644369059 480 G 480
Cdd:PRK10484 449 I 449
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
36-479 |
9.92e-11 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 64.13 E-value: 9.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSR-QDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYdgLIYSIGFLIGW 114
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRSTvSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGI--AVGNYEWNAAF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 115 PIILF--LIAERLRNLGRYTFADVASYRLQQKpIRTLSACGSLVVVALYLIAQMVGAGKL-IQLLFGLNYHVAVILVGIL 191
Cdd:cd10329 79 VLLLLgwVFLPFYIRSGVSTMPEFLEKRFGGR-SRVYLSVLSLILYVFTKISVDLYAGALvIKQLLGWDLYLSIIVLLVI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 192 MVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFA---EAVKVHpkgiaimspggLVSDPISALSLG 268
Cdd:cd10329 158 TAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYMAaipSGTAFH-----------LFRPPDDPDLPW 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 269 LALMFGTAGL--------PHILMRFFTVSDAKEARKSVFyatgFIGYFYILTFII----GFGAILLVSANPAFKDATGAL 336
Cdd:cd10329 227 PGLLLGYPILgiwywctdQVIVQRVLAAKNLKHARRGAL----FAGYLKLLPLFLmvlpGMIARALFPDLVACVVPCGNG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 337 LGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKngKATERDELKVSKITVVVLGLV 416
Cdd:cd10329 303 VGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRP--EASEKELVRVGRIATLVVVVI 380
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644369059 417 AIAL--------GILFEK-QNIAFMvgLAFSIAAscnfpIIILSMYWSRLTTRGAMIGGWLGLLTAVILMIL 479
Cdd:cd10329 381 SILWapiiqaqgGSLFNYiQSVLSY--LAPPIAA-----VFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLIL 445
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
36-479 |
1.23e-10 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 63.77 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWP 115
Cdd:cd11493 2 LAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 116 IILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSA---CGSLVV--VALYLIAQMVGAGkLIQLLFGLNYHVAVILVGI 190
Cdd:cd11493 82 IVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVtflVTRLLAdgVRLFAAAIPVSMI-LGADGVALSYIASILIISV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 191 LMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFDFNTLFAEAVKVHPkgIAIMSPGGLVSDPISALS--LG 268
Cdd:cd11493 161 VTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFHL--FDLSDLILGLTSPYTFWAaiIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 269 LALM----FGTAGLphILMRFFTVSDAKEARKSVFyATGFIGYFYILTFIIgFGAILLVSanpaFKDATGALLGGTNMAA 344
Cdd:cd11493 239 GALLsmasHGTDQL--MVQRLLACRNLRDAQKALI-GSGVVVFPQFALFLL-IGLLLYVY----YGGASLAALGLGSPDE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 345 VHLANAVGG--NFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKNgKATERDELKVSKITVVVLGLVAIALGI 422
Cdd:cd11493 311 VFPYFIVHElpAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRR-RLSDEKLLRASRLLTLVWAVVLVGIAL 389
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 423 LFEKQNIAfMVGLAFSIAA---SCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMIL 479
Cdd:cd11493 390 LFQYTDQP-VVELGLSIASftyGGLLGVFLLGLLTRRASQRDAIAAFIVGFLVMLLLIFG 448
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
52-486 |
3.49e-07 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 52.87 E-value: 3.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 52 WASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWPIILFLIAERLRNLGry 131
Cdd:cd11492 22 FFGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAYVLVGPITAYIFLPVFYNLQ-- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 132 tfadVAS---YrLQQ---KPIRTLSACGSLVVVALYL-IAQMVGAGKLIQLLfGLNYHVAVILVGILMVLYVLFGGMLAT 204
Cdd:cd11492 100 ----LTSvyeY-LELrfnRRVRLLASFLFILQMLLYLpIVIYAPALALSQVT-GINLHIIILVVGIVCIFYTTLGGLKAV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 205 TWVQIIKAVLLLAGASFMALMVMKSVNfDFNTLFAEAVKVHPKGIAIMSPGGLVSDPISALSLGLALMF--GTAGLPHIL 282
Cdd:cd11492 174 VWTDVFQVVVMFGGVLAVIILGTIDVG-GFSEVWEIAEEGGRLEFFNFDPDPTVRHTFWSLVIGGTFTWlsLYGVNQTQV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 283 MRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFgAIL------------LVSAN----PAF-KDATGALLGgtnMAAV 345
Cdd:cd11492 253 QRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGL-VIYakyhdcdpltagLIKKPdqllPYFvMDVLGHLPG---LPGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 346 hlanavggnfflgFISAVAFATILAVVAGLTlAGASAVSHDLYASVMKNgKATERDELKVSKITVVVLGLVAIALGILFE 425
Cdd:cd11492 329 -------------FVAGIFSAALSTLSSGLN-SLAAVILEDFIKPFFKK-KLSERQATNIMKLLVVVFGLLCIGLAFLVE 393
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644369059 426 KQNIAFMVGLA-FSIAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTIWVQ 486
Cdd:cd11492 394 KLGGVLQLSLSiFGITGGPLLGIFTLGMFFPWANSKGALVGLLVGLIFMLWIGIGGQIAIAP 455
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
39-509 |
7.71e-07 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 51.77 E-value: 7.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 39 FILFVGATLYITYWASKRTR--SRQDYYTAGGRITGLqnglAIAGDFM----SAASFLGISALVYTSGYDGLIYSIGFLI 112
Cdd:cd10328 1 FLLFTALVALISWYKTRGDDlsSSDGYFLAGRSLTGV----VIAGSLLltnlSTEQLVGLNGQAYALGMSVMAWEVTAAI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 113 GWPIILFLIAERLRNLGRYTFADVASYRLQQKpIRTLsacgslvVVALYLIAQMV---------GAGKLIQL-----LFG 178
Cdd:cd10328 77 ALIILALVFLPRYLKGGITTIPEFLEERYDET-TRRI-------VSILFLLGYVVillpivlysGALALNSLfdvseLLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 179 LNYHVA----VILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGA---SFMALMVMKSVNF--DFNTLFAeavkVHP-KG 248
Cdd:cd10328 149 ISYFQAlwllVWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGlliPILGLIALGDGSFlaGLDTLLT----AHPeKL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 249 IAIMSPGGLVsdPISALSLGLAL--MFGTAGLPHILMRFFTVSDAKEARKSVFYAtgfiGYFYILTfiigfGAILLVSAN 326
Cdd:cd10328 225 NAIGGADSPV--PFSTLFTGMLLvnLFYWCTNQAIIQRALAAKNLKEGQKGVLLA----GFFKLLV-----PLILVLPGI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 327 PAFKdATGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASvMKNGKATERDELKVS 406
Cdd:cd10328 294 IAFH-LYGDGLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKP-IINKNATDKQLVKVG 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 407 KITVVVLGLVAIALGILFEKQN---IAFMVGLA--FSIAAscnFPIIILSMYWSRLTTRGAMIggwlGLLTAVILMILGp 481
Cdd:cd10328 372 KIFGIVLALISMIIAPFIAYAPeglFNYLQQFNgfFSIPI---LAIVLVGFFTKRVPALAAKI----ALIFGVILYALL- 443
|
490 500
....*....|....*....|....*...
gi 644369059 482 tiwvQILGHEKPIYPYEYPALFSMIVAF 509
Cdd:cd10328 444 ----QFVFLVPIHFLHVLAILFVICVAI 467
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
38-218 |
1.33e-06 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 51.00 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 38 MFILFVGATLYITYWASKRT---RSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGW 114
Cdd:cd11503 5 VFAAMLLVSTGIGLFVGLARggqRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 115 PIILFLIAERLRNLGRYTFADVASYRLQqkpiRTLSACGSLvvvaLYLIAQMVGAGKLI-------QLLFGLNYHVAVIL 187
Cdd:cd11503 85 LMTAVLFMPVFYRLGITSTYQYLEMRFS----RAVRLCGTL----QFIVATMLYTGIVIyapalilNQVTGLDIWASLFS 156
|
170 180 190
....*....|....*....|....*....|.
gi 644369059 188 VGILMVLYVLFGGMLATTWVQIIKAVLLLAG 218
Cdd:cd11503 157 TGIICTFYTTVGGMKAVIWTDVFQVVVMLSG 187
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
32-478 |
1.84e-06 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 50.70 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 32 NIQAIVMFILFVgatLYITYWASKRTR--SRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSG-------YD 102
Cdd:cd11486 2 DISVIVIYFVVV---LAVGVWAMVSTNrgTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGiaiggfeWN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 103 GLIYSIgfLIGWPIILFLIAErlrnlGRYTFADVASYRLQQKPIRT-LSACGSLVVVALYLIAQMVGAGKLIQLLFGLNY 181
Cdd:cd11486 79 ALVVVV--VLGWLFVPIYIKA-----GVVTMPEYLRKRFGGQRIQVyLSVLSLCLYIFTKISADIFSGAIFINLALGLNL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 182 HVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNfDFNTLFAEAVKVHPKGIA---------IM 252
Cdd:cd11486 152 YLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVG-GYDAFMEKYMTAIPSVIGtgnstsqekCY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 253 SPGG----LVSDPISALSLGLALMFGTAglphILMRFFTVSD------AKEARKSVFYATGFI--GYFYIL-TFIIGFGA 319
Cdd:cd11486 231 TPRAdsfhIFRDPITGDLPWPGLLFGLS----ILTLWYWCTDqvivqrCLSAKNMSHVKAGCIlcGYLKLLpMFIMVMPG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 320 IL--------LVSANPAF-KDATGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYAS 390
Cdd:cd11486 307 MIsrilytdeIACVVPDEcKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTK 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 391 VMKngKATERDELKVSKITVVVLGLVAIALGILFEKQNIAFMVGLAFSIAASCNFPI---IILSMYWSRLTTRGAMIGGW 467
Cdd:cd11486 387 VRK--KASEKELMIAGRLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIaavFLLAIFCKRVNEPGAFWGLC 464
|
490
....*....|.
gi 644369059 468 LGLLTAVILMI 478
Cdd:cd11486 465 VGLLVGLARMI 475
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
32-479 |
6.34e-06 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 49.16 E-value: 6.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 32 NIQAIVMFILFVgatLYITYWASKRTR--SRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGY--DGLIYS 107
Cdd:cd11488 1 DIAVVVVYFVFV---LAVGIWSSIRASrgTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLavGGFEWN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 108 IGFLI---GWPIILFLIAErlrnlGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKL-IQLLFGLNYHV 183
Cdd:cd11488 78 AAWVLialGWIFVPVYIAA-----GVVTMPEYLKKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALfIQVSLGWNLYL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 184 AVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGASFMALMVMKSVNFdFNTLFAEAVKVHPKGIAIMSPGGL------ 257
Cdd:cd11488 153 STVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGW-YPGLEQQYEKAIPALTVPNTTCHLprsdaf 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 258 --VSDPISALSLGLALMFGTAGLPH--------ILMRFFTVSDAKEARKSVFYAtgfiGYFYILT--FIIGFGAIllvsA 325
Cdd:cd11488 232 hiFRDPVTGDIPWPGLIFGLTVLATwvwctdqvIVQRSLSAKNLSHAKGGSVLG----GYLKILPmfFVVMPGMI----S 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 326 NPAFKDAT------------GALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMK 393
Cdd:cd11488 304 RALFPDEVgcvdpdecqkicGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRR 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 394 NgkATERDELKVSKITVVVLGLVAIALGILFEKQNIAFMVGLAFSIAASCNFPI---IILSMYWSRLTTRGAMIGGWLGL 470
Cdd:cd11488 384 R--ASEQELMVVGRVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPItavFILAIFWKRVNEPGAFWGLMVGL 461
|
....*....
gi 644369059 471 LTAVILMIL 479
Cdd:cd11488 462 VVGLVRMIM 470
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
37-218 |
1.95e-05 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 47.18 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 37 VMFILFVGATLYITYWASKRtRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSG----YDGLIYSIGFLI 112
Cdd:cd11504 11 LLLVISAGIGLYYACTGGKQ-KTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGtqywFLGCSYFLGLLI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 113 gwPIILFL-IAERLRNLGRYTFADVASyrlqQKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGIL 191
Cdd:cd11504 90 --PAHVFIpVFYRLELTSAYEYLELRF----NKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISVLAMGVV 163
|
170 180
....*....|....*....|....*..
gi 644369059 192 MVLYVLFGGMLATTWVQIIKAVLLLAG 218
Cdd:cd11504 164 CTFYTALGGLKAVIWTDVFQTVVMFAG 190
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
32-479 |
1.51e-04 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 44.47 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 32 NIQAIVMFILFVGATLYITYWASKRTrSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFL 111
Cdd:cd11491 1 DIAVVALYFILVMCIGIYAMWKSNRS-TVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNAL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 112 IGWPIILFLIAERLRNLGRYTFADVASYRLQQKPIRTLSACGSLVVVALYLIAQMVGAGKL-IQLLFGLNYHVAVILVGI 190
Cdd:cd11491 80 ILLQLLGWVFIPVYIRSGVYTLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALfIQEALGWNLYVSIILLLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 191 LMVLYVLFGGMLATTWVQIIKAVLLLAGA-SFMALMVMKSVNFD-------------------FNTLFAEAVKVHPKGIA 250
Cdd:cd11491 160 LTALLTVTGGLAAVIYTDTLQAFLMIIGAlTLMIISMMEIGGFEgvksrymlaspnvtsilltYNLSNTNSCCVHPKKDA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 251 IMSPGGLVSDPISALSLGL----ALMFGTAGLPHILMRFFTVSDAKEARKSVFYAtGFIGYFYILTFIIG-------FGA 319
Cdd:cd11491 240 FKLLRDPTDEDVPWPGFILgqtpASIWYWCADQVIVQRVLAAKSLSHAQGATLMA-GFIKLLPLFIIVIPgmisrilFPD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 320 ILLVSANPAFKDATGALLGGTNMAAVHLANAVGGNFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVMKngKATE 399
Cdd:cd11491 319 DIACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRK--KASS 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 400 RDELKVSKITVVVLGLVAIA-LGILFEKQNIAFMVGLAfSIAASCNFPI---IILSMYWSRLTTRGAMIGGWLGLLTAVI 475
Cdd:cd11491 397 RELMIVGRIFVAVMVVISIAwIPVIQEMQGGQLYLYIQ-EVAAYLTPPVaslYLLAIFWKRTTEQGAFYGGMAGFVLGAV 475
|
....
gi 644369059 476 LMIL 479
Cdd:cd11491 476 RLIL 479
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
32-219 |
1.91e-03 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 41.05 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 32 NIQAIVMFILFVGATLYITYWASKRTrSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIG-- 109
Cdd:cd11490 1 DIVVLVLYFLFVLAVGLWSMWKTKRS-TVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNgl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 110 ---FLIGWPIILFLIAERLRNLGRYTFADVASYRLQqkpirtlsacgsLVVVALYLI--------AQMVGAGKLIQLLFG 178
Cdd:cd11490 80 fmvLVLAWLFLPIYIASRVTTMPEYLKKRFGGKRIQ------------IFLAVLYLFiyiftkisVDMYAGAVFIQQALQ 147
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 644369059 179 LNYHVAVILVGILMVLYVLFGGMLATTWVQIIKAVLLLAGA 219
Cdd:cd11490 148 WDLYLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGA 188
|
|
| SLC5sbd_SMCT1 |
cd11519 |
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ... |
40-218 |
2.30e-03 |
|
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271402 Cd Length: 542 Bit Score: 40.60 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 40 ILFVGATLYITY-WASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSGYDGLIYSIGFLIGWPIIL 118
Cdd:cd11519 15 MLLISAGIGIYYaFAGGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYAIVVVISA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 119 FLIAERLRNLGRYTFADVASYRLQqKPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVILVGILMVLYVLF 198
Cdd:cd11519 95 EVFLPVFYRLGITSTYEYLELRFN-KCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTL 173
|
170 180
....*....|....*....|
gi 644369059 199 GGMLATTWVQIIKAVLLLAG 218
Cdd:cd11519 174 GGLKAVIWTDVFQVGIMVAG 193
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
36-483 |
4.34e-03 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 39.60 E-value: 4.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 36 IVMFILFVGATLYITYWASKRTRSRQDYYTAGGRITGLQNGLAIAGDFMSAASFLGISALVYTSG-----YDgLIYSIGF 110
Cdd:cd10325 4 IVYVILIIGLGLWVSREKKGGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGlaiasYE-WMAAITL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 111 LIgwpIILFLIAERLRNlGRYTFADVASYRLQqKPIRTLSACGSLVV-VALYLIAQMVGAGKLIQLLFGLNYHVAVILVG 189
Cdd:cd10325 83 II---VAKFFLPIFLKN-GIYTMPQFLEERYD-GRVRTIMAVFWLLLyVFVNLTSVLYLGALAIETITGIPLTYSIIGLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 190 ILMVLYVLFGGMLATTWVQIIKAVLLLAGA---SFMALMVMKSV--NFDFNTLFAEAVKVHPKGIaIMSPGGLVSDP--- 261
Cdd:cd10325 158 LFAAAYSIYGGLKAVAWTDVIQVVFLVLGGlvtTYIALSLLGGGegVFAGFTLLAAEAPEHFHMI-LDKSNPEDAYKdlp 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 262 -ISALSLGLALM-FGTAGL-PHILMRFFTVSDAKEARKSVFYAtGFIGyfYILTFIIGFGAIL-LVSANPAFKDATGALL 337
Cdd:cd10325 237 gIAVLLGGLWVAnLSYWGFnQYIIQRALAAKSLSEAQKGIVFA-AFLK--LLIPFIVVIPGIAaYVLASNLLLPAATGIE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644369059 338 GGTNMAAVHLANAVGGnfFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASvMKNGKATERDELKVSKITVVVLGLVA 417
Cdd:cd10325 314 KPDQAYPWLLRNLPTG--LKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKK-YIPKKASEKQLVNVGRLAAVIALIIA 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644369059 418 IALGILFEKQNIAFMVGLAFS-IAASCNFPIIILSMYWSRLTTRGAMIGGWLGLLTAVILMILGPTI 483
Cdd:cd10325 391 ALIAPPLLGLDQAFQYIQEYTgFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSALFKFLLPEL 457
|
|
| |
