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Conserved domains on  [gi|644352050|ref|WP_025302051|]
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MULTISPECIES: MFS transporter [Serratia]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
24-418 2.19e-36

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17502:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 337  Bit Score: 137.31  E-value: 2.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALA 103
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 104 PSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMA 183
Cdd:cd17502   81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 184 LyaaftflilpkgkaqqAAAPLPTaqlllltvavlvvsagslahSAWINLAGIALSLVLMAWLLkreahsrarllphgal 263
Cdd:cd17502  161 L----------------ALALLRT--------------------ILLSSIFGFLFGGALFGLIY---------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 264 rrgsslaalyittallvigmtseiFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGW--RGAGIRRAIVSGPLFV 341
Cdd:cd17502  189 ------------------------YLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALisKTGRYKPLIVIGTILM 244
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 342 LVGLLALAILMPMPSGGHWqalapiVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAAL 418
Cdd:cd17502  245 SVGAGLLTTLTLDTSKWLL------IGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
24-418 2.19e-36

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 137.31  E-value: 2.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALA 103
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 104 PSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMA 183
Cdd:cd17502   81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 184 LyaaftflilpkgkaqqAAAPLPTaqlllltvavlvvsagslahSAWINLAGIALSLVLMAWLLkreahsrarllphgal 263
Cdd:cd17502  161 L----------------ALALLRT--------------------ILLSSIFGFLFGGALFGLIY---------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 264 rrgsslaalyittallvigmtseiFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGW--RGAGIRRAIVSGPLFV 341
Cdd:cd17502  189 ------------------------YLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALisKTGRYKPLIVIGTILM 244
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 342 LVGLLALAILMPMPSGGHWqalapiVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAAL 418
Cdd:cd17502  245 SVGAGLLTTLTLDTSKWLL------IGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
21-422 6.43e-23

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 101.30  E-value: 6.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   21 AIALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAAL 99
Cdd:TIGR00711   4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGsSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  100 CALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILL 179
Cdd:TIGR00711  84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  180 PIMALYAAFTFLILPKGKAQQ-------AAAPLPTAQLLLLTVAVLVVSAGSLAHSAWINLAgiALSLVLMAWLLKREAH 252
Cdd:TIGR00711 164 PIGIIVVVVAFFILPRDKPAAsenfdflGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILS--ITGLVAIIAFVVWELT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  253 SRARLL-PHGALRRGSSLAALYITtaLLVIGM-TSEIFVPYFLQLLHGQSPLISGYIAAAMAagwtLSEILSSGWRGAGI 330
Cdd:TIGR00711 242 DDNPLVdLRLFKYRNFTIGCVYMS--LLGLGLyGSFYLLPLYLQQVLGYTALQAGLHILPVG----LAPMLSSPIAGRMG 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  331 RRAIVSGPLFVLVGLLALAILMPMPSGGHWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLF 410
Cdd:TIGR00711 316 DKIDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
                         410
                  ....*....|..
gi 644352050  411 ATAFGAALAGMI 422
Cdd:TIGR00711 396 GGSIGTALITTI 407
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-413 5.18e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 96.97  E-value: 5.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  14 SGKNAASAIALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLF 92
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  93 FIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWR 172
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 173 WAFGILLPIMALYAAFTFLILPKGKAQQAAAPLPTAQLllltvavlvvsagslahsawinlagialslvlmawllkreah 252
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------------------------ 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 253 srarllphgALRRGSSLAALYITTALLVIGMTSEIFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGW-RGAGIR 331
Cdd:COG2814  203 ---------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLaDRFGRR 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 332 RAIVSGPLFVLVGLLALAILmpmpsgghwQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFA 411
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALA---------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344

                 ..
gi 644352050 412 TA 413
Cdd:COG2814  345 GP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
24-416 5.27e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.92  E-value: 5.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   24 LSLGVALHAINILVATTILPSVVQDIGGLD--LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCA 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISptEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  102 LAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPI 181
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  182 MALYAAFTFLILPKGKAqqaaaplptaqlllltvavlvvsagslahsawinlagialslvlmAWLLKREAHSRARLLPHG 261
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES---------------------------------------------KRPKPAEEARLSLIVAWK 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  262 ALRRGSSLAALYITTALLVIGMTSEIFVPYFLQLLHGQSPLISGYIAAAMAAGwtlseiLSSGWRGAGIRRAIVSGPLFV 341
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLG------AIGRLLLGRLSDRLGRRRRLL 269
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644352050  342 LVGLLALAILMPMPSGGHWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGA 416
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK10504 PRK10504
putative transporter; Provisional
24-194 4.61e-09

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 58.59  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLyawNTTLFVVASILGSAL----SARLLSGYGARSAYLVASLFFIAGAAL 99
Cdd:PRK10504  15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPL---HMHMVIVSYVLTVAVmlpaSGWLADRVGVRNIFFTAIVLFTLGSLF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 100 CALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILL 179
Cdd:PRK10504  92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171
                        170
                 ....*....|....*
gi 644352050 180 PIMALYAAFTFLILP 194
Cdd:PRK10504 172 PVGIIGAIATLMLMP 186
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
24-418 2.19e-36

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 137.31  E-value: 2.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALA 103
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 104 PSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMA 183
Cdd:cd17502   81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 184 LyaaftflilpkgkaqqAAAPLPTaqlllltvavlvvsagslahSAWINLAGIALSLVLMAWLLkreahsrarllphgal 263
Cdd:cd17502  161 L----------------ALALLRT--------------------ILLSSIFGFLFGGALFGLIY---------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 264 rrgsslaalyittallvigmtseiFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGW--RGAGIRRAIVSGPLFV 341
Cdd:cd17502  189 ------------------------YLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALisKTGRYKPLIVIGTILM 244
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 342 LVGLLALAILMPMPSGGHWqalapiVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAAL 418
Cdd:cd17502  245 SVGAGLLTTLTLDTSKWLL------IGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
24-422 5.70e-24

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 103.02  E-value: 5.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGG-LDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCAL 102
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGAsPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 103 APSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIM 182
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 183 ALyaaftflilpkgkaqqaaaplptaqlllltvavlvvsagslahsawinlagialslvlmawllkreahsrarLLPHGA 262
Cdd:cd17321  161 LV------------------------------------------------------------------------ALLLAR 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 263 LRRGSSLAALYITTALlvigMTSEIFVPYFLQLLHGQSPLISGYI----AAAMAAGWTLSEILSSGWrgaGIRRAIVSGP 338
Cdd:cd17321  169 TFSGAVLAAFLLGAAL----GGLLFLLPLYLQGVLGYSPLQAGLAllplALAMLVAAPLAGRLADRF---GPRLVLVAGL 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 339 LFVLVGLLALAILMPMPSgghwqaLAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAAL 418
Cdd:cd17321  242 LLTAVGLLLLALLGADSS------VWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVAL 315

                 ....
gi 644352050 419 AGMI 422
Cdd:cd17321  316 LGAL 319
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
21-422 6.43e-23

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 101.30  E-value: 6.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   21 AIALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAAL 99
Cdd:TIGR00711   4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGsSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  100 CALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILL 179
Cdd:TIGR00711  84 CGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  180 PIMALYAAFTFLILPKGKAQQ-------AAAPLPTAQLLLLTVAVLVVSAGSLAHSAWINLAgiALSLVLMAWLLKREAH 252
Cdd:TIGR00711 164 PIGIIVVVVAFFILPRDKPAAsenfdflGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILS--ITGLVAIIAFVVWELT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  253 SRARLL-PHGALRRGSSLAALYITtaLLVIGM-TSEIFVPYFLQLLHGQSPLISGYIAAAMAagwtLSEILSSGWRGAGI 330
Cdd:TIGR00711 242 DDNPLVdLRLFKYRNFTIGCVYMS--LLGLGLyGSFYLLPLYLQQVLGYTALQAGLHILPVG----LAPMLSSPIAGRMG 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  331 RRAIVSGPLFVLVGLLALAILMPMPSGGHWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLF 410
Cdd:TIGR00711 316 DKIDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395
                         410
                  ....*....|..
gi 644352050  411 ATAFGAALAGMI 422
Cdd:TIGR00711 396 GGSIGTALITTI 407
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-413 5.18e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 96.97  E-value: 5.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  14 SGKNAASAIALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLF 92
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  93 FIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWR 172
Cdd:COG2814   85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 173 WAFGILLPIMALYAAFTFLILPKGKAQQAAAPLPTAQLllltvavlvvsagslahsawinlagialslvlmawllkreah 252
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------------------------ 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 253 srarllphgALRRGSSLAALYITTALLVIGMTSEIFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGW-RGAGIR 331
Cdd:COG2814  203 ---------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLaDRFGRR 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 332 RAIVSGPLFVLVGLLALAILmpmpsgghwQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFA 411
Cdd:COG2814  274 RLLLIGLLLLALGLLLLALA---------GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344

                 ..
gi 644352050 412 TA 413
Cdd:COG2814  345 GP 346
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
24-422 5.49e-22

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 97.26  E-value: 5.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCAL 102
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGaSLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 103 APSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIm 182
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 183 alyAAFTFLILPkgkaqqaaaplptaqlllltvavlvvsagslahsawinlagialslvlmawllkreahsrarLLPHGA 262
Cdd:cd17503  160 ---GILALLLAP--------------------------------------------------------------LLDLRL 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 263 LRRGSSLAALYITTALLVIGMTSEIFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILssgwrgAGIRRAIVSGPLFVL 342
Cdd:cd17503  175 FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPL------VGRLLDKFGPRLLLL 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 343 VGLLALAI-LMPMPSGGHWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAALAGM 421
Cdd:cd17503  249 AGLLLLALgTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328

                 .
gi 644352050 422 I 422
Cdd:cd17503  329 L 329
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
22-293 8.97e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 80.63  E-value: 8.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  22 IALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALC 100
Cdd:COG0477   17 LALALGTFLEGLDFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 101 ALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLP 180
Cdd:COG0477   97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 181 IMALYAAFTFLILPKGKAQQAAAPLPTAQLLLLTVAVLVVSAGSLAHSAWINLAGIALSLVLMAWLLKREAHSRARLLPH 260
Cdd:COG0477  177 LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLAL 256
                        250       260       270
                 ....*....|....*....|....*....|...
gi 644352050 261 GALRRGSSLAALYITTALLVIGMTSEIFVPYFL 293
Cdd:COG0477  257 LLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
56-422 1.27e-15

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 78.39  E-value: 1.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  56 AWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGlIFALSYAMINLVF 135
Cdd:cd17504   34 SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEF 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 136 EQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLILPKgkaqqaaaplptaqlllltv 215
Cdd:cd17504  113 PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLR-------------------- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 216 avlvvsagslahsawinlagialslvlmawLLKReahsrarllphgalrrgSSLAALYITTALLVIGMTSEIF-VPYFLQ 294
Cdd:cd17504  173 ------------------------------LLRR-----------------RNVLLANITALLAGFGMFMVFQlLPQLLQ 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 295 LlhgqsPLISGYIAAAMAAGWTLSEILSSGW----------RGAGIRRAIVSGPLFVLVGLLALAILMpmpsgghwQALA 364
Cdd:cd17504  206 L-----PTPTGFGLGITEAGLLLLPGALVMLiagplagrliARVGPRRVLLIGLVISAVGLLLLALLH--------SSLW 272
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 644352050 365 PIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAALAGMI 422
Cdd:cd17504  273 ALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
80-424 1.85e-15

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 78.00  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  80 YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGP 159
Cdd:cd17320   61 FGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAP 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 160 AVGGIFAELNAWRWAFGILLPIMALYAAFTFLILPKGKAQQAAAPLPTAQLLLLTVAVLVVSAGSLAhsawinLAGIALS 239
Cdd:cd17320  141 LLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYA------LALGLSF 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 240 LVLMAWLlkreahsrarllphgalrrgSSLAALYITtallVIGMTSEIFVPYFlqllhgqSPLISGYIAAAMAAGWTLSE 319
Cdd:cd17320  215 AGLFAYL--------------------AAAPFIYIE----QLGLSPAQFGLLF-------ALNAIALILGSLLNGRLVRR 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 320 IlssgwrgaGIRRAIvsgpLFVLVGLLALAILMPMPSGGHWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEAdKDI 399
Cdd:cd17320  264 F--------GPRRLL----RLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHV-AGT 330
                        330       340
                 ....*....|....*....|....*
gi 644352050 400 AGASITTVQLFATAFGAALAGMIAN 424
Cdd:cd17320  331 ASALLGFLQFLIGALAGALVGLLPN 355
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
22-429 2.36e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 77.59  E-value: 2.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  22 IALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALC 100
Cdd:cd17324    2 LALALAAFAIGTTEYVIQGLLPDIARDFGvSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 101 ALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLP 180
Cdd:cd17324   82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 181 IMALYAAFTFLILPKGKAQQAAAPLPTAQLLlltvavlvvsagslahsawinlagialslvlmawllkreahsrarllph 260
Cdd:cd17324  162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLL------------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 261 gALRRGSSLAALYITTALLVIGMTS--EIFVPYFLQLLHGQSPLISGYIAAAMAAGwTLSEILSSGWRGAGIRRAIVSGP 338
Cdd:cd17324  193 -LLLRNPRLRLAYLITFLLFGGFFAlyTYLAPFLTDVPGFSSSAIIGLLLLFGVAG-VVGSPLAGRLADRGGRRALLIAL 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 339 LFVLVGLLALAILmpmpsgghWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEAdKDIAGASITTVQLFATAFGAAL 418
Cdd:cd17324  271 LLLAAALLLLTLL--------GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAAL 341
                        410
                 ....*....|.
gi 644352050 419 AGMIANLAGLN 429
Cdd:cd17324  342 GGLVLDHGGWA 352
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
24-428 4.51e-15

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 76.46  E-value: 4.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLYA-WNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCAL 102
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIgLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 103 APSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIM 182
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 183 ALYAAFTFLILPKGKAQQAaaplptaqlllltvavlvvsagslahsawinlagialslvlmawllKREAHSRARLLPHGA 262
Cdd:cd17325  161 LLALVLALLLLPEPRPPPN----------------------------------------------KRAVSAARLRSGLRL 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 263 LRRGSSLAALYITTALLVIGMTS-EIFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGWRGAGIRRAIVSGPLFV 341
Cdd:cd17325  195 LLRDRRLLALFLAIFVLAFAFGAlEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 342 LVGLLALAILMPmpsgghwqALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAALAGM 421
Cdd:cd17325  275 SAVALLLLPLAT--------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346

                 ....*..
gi 644352050 422 IANLAGL 428
Cdd:cd17325  347 LYDAFGF 353
MFS_1 pfam07690
Major Facilitator Superfamily;
24-416 5.27e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.92  E-value: 5.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   24 LSLGVALHAINILVATTILPSVVQDIGGLD--LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCA 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISptEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  102 LAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPI 181
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  182 MALYAAFTFLILPKGKAqqaaaplptaqlllltvavlvvsagslahsawinlagialslvlmAWLLKREAHSRARLLPHG 261
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES---------------------------------------------KRPKPAEEARLSLIVAWK 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  262 ALRRGSSLAALYITTALLVIGMTSEIFVPYFLQLLHGQSPLISGYIAAAMAAGwtlseiLSSGWRGAGIRRAIVSGPLFV 341
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLG------AIGRLLLGRLSDRLGRRRRLL 269
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644352050  342 LVGLLALAILMPMPSGGHWQALAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGA 416
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
22-424 6.32e-15

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 76.90  E-value: 6.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  22 IALSLGVALHAINILVATTILPSVVQDIGGLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCA 101
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 102 LAPSMPVMLIGRTVQGFGGGLIFaLSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNA--WRWAFGILL 179
Cdd:cd06179   81 TAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 180 PIMALYAAFTFLILPKGKAQQAAAPLPTAQLLLLTVAVLVVSAGSLA---------------HSAWInLAGIALSLVLMA 244
Cdd:cd06179  160 IFNALALILLFFFYHPPPRPQLHGSSTRQKLKRLDWVGLFLLIAGLVlfllglswggnpypwSSAHV-IAPLVIGGVLLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 245 WLLKREAHSRA-RLLPHGALRRGSSLAALYITTALLVIGMTS-EIFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILS 322
Cdd:cd06179  239 AFGLYEWKGTKdGLLPPRLLFRGRNFALILIVAFVEGMIFYSlNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 323 S--GWRGAGIRRAIVSGPLFVLVGLLALAILMPMPSGghwQALAPIVIAlllvgfGIGFGWPHLLTR-ILQV-APEADKD 398
Cdd:cd06179  319 GllLTKIKHIKWQLVAGFVLFTAFLALLALITPDNKA---LAIAFSVLA------GIGIGGPLVLAIvIVQLsVPPEDIG 389
                        410       420
                 ....*....|....*....|....*.
gi 644352050 399 IAGASITTVQLFATAFGAALAGMIAN 424
Cdd:cd06179  390 TASGLLGSARALGGAVGTAIFTSILS 415
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
63-429 1.55e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 74.91  E-value: 1.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  63 VVASILGSALSARllsgYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPR 142
Cdd:cd17474   48 AVLMPVAGVLADR----FGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 143 AMALISAMWGIATLVGPAVGGIFAELnAWRWAFGILLPIMALYAAFTFLILPKGKAQQAAaplptaqlllltvavlvVSA 222
Cdd:cd17474  124 AMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLPEPKEKAKS-----------------SSA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 223 GSLAHSAWINLAGIALSLVLMAWLLkreahsrarllphgalrrgsslaaLYITTALLVigmtseiFVPYFLQLLHGQSPL 302
Cdd:cd17474  186 TKLRDLKKALRGRGLLTFLVSAFLY------------------------FFLYFAFLT-------YLPFLLELLYGISPI 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 303 ISGYIAAAMAAGWTLSEILSSGWRGAGIRRAIVsgplfVLVGLLALAILMPMPSGGHWQALapIVIALLLVGFGIGFGWP 382
Cdd:cd17474  235 IIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI-----LVIGLLLYALSLLLLGFVPSLAL--LLIAIVLFGLGLGLNLP 307
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 644352050 383 HLLTRILQVAPEADKDIAGASITTVQLFATAFGAALAGMIANLAGLN 429
Cdd:cd17474  308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLS 354
2_A_01_02 TIGR00880
Multidrug resistance protein;
57-194 2.96e-12

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 63.82  E-value: 2.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   57 WNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFE 136
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 644352050  137 QRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLILP 194
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
60-429 1.41e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 66.03  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  60 TLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVfEQRL 139
Cdd:COG0738   50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPET 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 140 WPRAMALISAMWGIATLVGPAVGGIFAELN---AWRWAFGILLPIMALYAAFTFLI-LPKGKAQQAAAplptaqlllltv 215
Cdd:COG0738  129 AASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWHLPYLILAVLLLLLALLFLRSkLPEIEEEEEEA------------ 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 216 avlvvsagslahsawinlagialslvlmawllKREAHSRARLLPHGALRRGSSLAALYITTALLVIGmtseiFVPYFLQL 295
Cdd:COG0738  197 --------------------------------AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGD-----WLPLYLKD 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 296 LHGQSPLISGYIAAAMAAGWTLSEILssgwrGAGIRRAIVSGPLFVLVGLLA-LAILMPMPSGGHWQALapivIALLLVG 374
Cdd:COG0738  240 VLGLSEATAALGLSLFWGGMTIGRFL-----GGFLLKRFGPVRLLRLSALLAaVGLLLALLAPGPWLAL----IGLALVG 310
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 644352050 375 FGIGFGWPHLLTRILQVAPEaDKDIAGASITTVQLFATAFGAALAGMIANLAGLN 429
Cdd:COG0738  311 LGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLR 364
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
58-194 1.56e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 65.67  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  58 NTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQ 137
Cdd:cd17323   39 GVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTP 118
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 138 RLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLILP 194
Cdd:cd17323  119 EERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
22-193 3.48e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 64.51  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  22 IALSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALC 100
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 101 ALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLP 180
Cdd:COG2271   93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
                        170
                 ....*....|...
gi 644352050 181 IMALYAAFTFLIL 193
Cdd:COG2271  173 PGLLLALLRFWLL 185
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
18-208 3.56e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 61.81  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  18 AASAIALSLGVALHAINILVATTILPSVVQDIG-----GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLF 92
Cdd:COG2807   13 RAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRadlglSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  93 FIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLwPRAMALISAMWGIATLVGPAVGGIFAELNAWR 172
Cdd:COG2807   93 LAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 644352050 173 WAFGILLPIMALYAAFTFLILPKGKAQQAAAPLPTA 208
Cdd:COG2807  172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAAS 207
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
55-208 4.59e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.44  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  55 YAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLV 134
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 135 FEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLIL---PKGKAQQAAAPLPTA 208
Cdd:COG2223  122 FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLrdpPAGAAAAAKASLRDQ 198
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
67-427 1.83e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 59.51  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  67 ILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMAL 146
Cdd:cd17473   49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 147 ISAMWGIATLVGPAVGGIFAELNaWRWAFgillpimalyaaftflilpkgkaqqaaaplptaqlllltvavlvvsagsla 226
Cdd:cd17473  129 QSAAMSLGGVVFLLLGGALAEIG-WRAPF--------------------------------------------------- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 227 hsaWINLAGIALSLVLMAWLLKREAHSRARLLPHGALRRGSSLAALYITTALLVIGM----TSEIFVPYFLQLLHGQSPL 302
Cdd:cd17473  157 ---LVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMllfyVIPIQLPFLLQERGGGSAA 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 303 ISGYIAAAMAAGWTLSEILssgwrgAGIRRAIVSGPLFVLVGLLALAI---LMPMPSGghwqaLAPIVIALLLVGFGIGF 379
Cdd:cd17473  234 LIGLALAIASLAGAIGALL------FGRLKRRLGKRRLLAIGFALMALgflLLALASG-----LWVVLLGAILAGLGFGL 302
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 644352050 380 GWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGAALAGMIANLAG 427
Cdd:cd17473  303 LLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
PRK10504 PRK10504
putative transporter; Provisional
24-194 4.61e-09

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 58.59  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLyawNTTLFVVASILGSAL----SARLLSGYGARSAYLVASLFFIAGAAL 99
Cdd:PRK10504  15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPL---HMHMVIVSYVLTVAVmlpaSGWLADRVGVRNIFFTAIVLFTLGSLF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 100 CALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILL 179
Cdd:PRK10504  92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171
                        170
                 ....*....|....*
gi 644352050 180 PIMALYAAFTFLILP 194
Cdd:PRK10504 172 PVGIIGAIATLMLMP 186
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
80-193 5.21e-09

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 58.03  E-value: 5.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  80 YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGP 159
Cdd:PRK15402  75 IGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGP 154
                         90       100       110
                 ....*....|....*....|....*....|....
gi 644352050 160 AVGGIFAELNAWRWAFGILlpimALYAAFTFLIL 193
Cdd:PRK15402 155 LVGAALIHVLPWRGMFVLF----AALAALSFFGL 184
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
71-192 1.42e-08

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 56.50  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  71 ALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPR-AMALISA 149
Cdd:cd17476   51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGA 130
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 644352050 150 MWGIATLVGPAVGGIFAELNAWRWAFGillpIMALYAAFTFLI 192
Cdd:cd17476  131 TAPLGFALGGVFGGLFAQLAWWPWIFW----FLAILAAIVAVA 169
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
24-194 1.13e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 53.74  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLDLYAWNTTLFVVASILGSALSARLLSG----YGARSAYLVASLFFIAGAAL 99
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRlsdrYGRKPVLLLSLAGSAVSYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 100 CALAPSMPVMLIGRTVQG-FGGGLIFALSYAMINLVFEQRlwPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGIL 178
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGlTGGNVSVAQAYIADITDEEER--AKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
                        170
                 ....*....|....*.
gi 644352050 179 LPIMALYAAFTFLILP 194
Cdd:cd17330  159 AALALLNLVLVLFFLP 174
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
42-194 1.18e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 53.81  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  42 LPSVVQDIGGLDLYAWNTTLFVVASILGSALSArLLSG-----YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQ 116
Cdd:cd17360   20 LLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGA-AIGGwlndrFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLV 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 644352050 117 GFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAEL-NAWRWAFGILLpIMALYAAFTFLILP 194
Cdd:cd17360   99 GLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLGLAA-VPAVLQFIGLLFLP 176
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
22-195 1.73e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.95  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  22 IALSLGVALHAINILVATTILPSVVQDIGGLDLY--AWNTTLFVVASILGSALSARLLSGYGARS--AYLVASLFFIAGA 97
Cdd:COG2271  183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAqaGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALAL 262
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  98 ALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGI 177
Cdd:COG2271  263 LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
                        170
                 ....*....|....*...
gi 644352050 178 LLPIMALYAAFTFLILPK 195
Cdd:COG2271  343 LAALALLAALLALLLLRE 360
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
24-194 2.39e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.81  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLD-LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCAL 102
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSAsQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 103 APSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNA--WRWAFGILLP 180
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAA 160
                        170
                 ....*....|....
gi 644352050 181 IMALYAAFTFLILP 194
Cdd:cd06174  161 LALLAAILLLLVVP 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
22-193 2.74e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.58  E-value: 2.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  22 IALSLGVALHAINILVATTILPSVVQDIGGLDLYAWNT--TLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAAL 99
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLlfGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 100 CALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILL 179
Cdd:cd17325  282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
                        170
                 ....*....|....
gi 644352050 180 PIMALYAAFTFLIL 193
Cdd:cd17325  362 ALLLLAAVLFLLLR 375
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
24-184 5.06e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 51.79  E-value: 5.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCAL 102
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGvSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 103 APSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIM 182
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160

                 ..
gi 644352050 183 AL 184
Cdd:cd17477  161 AL 162
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
62-198 5.81e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 51.42  E-value: 5.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  62 FVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWP 141
Cdd:cd17315   43 LLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRG 122
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 644352050 142 RAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIM-ALYAAFTFLILPKGKA 198
Cdd:cd17315  123 ALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVpALLQLLLMFFLPESRA 180
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
40-192 1.10e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.67  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  40 TILPSVVQDIGGLDLYA-WNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGF 118
Cdd:cd17489   17 PVLPLYAHDLGGSEAVAgLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI 96
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644352050 119 GGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLI 192
Cdd:cd17489   97 GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
21-193 2.17e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.52  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  21 AIALSLGVALHAINILVATTILPSVVQDiggldlYAWNTTLFVVASILGSALSARLLSG---------YGARSAYLVASL 91
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAE------FSLGLSLLQTGLLFAAGFLGRPIGAllfgylgdrIGRKKALILTLL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  92 FFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGI----ATLVGPAVGGIFAE 167
Cdd:cd17316   75 LFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALgallAALVASLLIPLLSG 154
                        170       180
                 ....*....|....*....|....*...
gi 644352050 168 LNAWRWAF--GILLPIMALYAAFTFLIL 193
Cdd:cd17316  155 DWGWRILFliGALPALLALLLRRRTLLL 182
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
60-206 2.30e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  60 TLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRL 139
Cdd:cd17329   42 ALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN 121
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 140 WPRAMALISAMWGIATLVGPAVGGIFAELNAwRWAFGILLPIMALYAAFTFLILPKGKAQQAAAPLP 206
Cdd:cd17329  122 RTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKT 187
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
62-196 2.62e-06

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 49.66  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  62 FVVASILGSALSARLLSG-----YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFE 136
Cdd:cd17362   43 LVVSGSLLGALLGSLVAGalidrLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSP 122
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644352050 137 QRLWPRAMALISAMWGIATLVGPAVGGIFAEL-NAWRWAFGILLPImALYAAFTFLILPKG 196
Cdd:cd17362  123 SHIRGLLVSLKELFIVLGILLGYVSGYAFADVvGGWRYMYGLAAPP-ALLLGIGMWFLPPS 182
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
55-195 5.59e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 48.34  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  55 YAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLV 134
Cdd:cd17319   40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEW 119
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644352050 135 FEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLILPK 195
Cdd:cd17319  120 FPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ 180
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
24-192 7.33e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.00  E-value: 7.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  24 LSLGVALHAINILVATTILPSVVQDIGGLD--LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCA 101
Cdd:cd06173  213 LLLALALFALLGGALTVLLPLLAKEVLGGGaaGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 102 LAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPI 181
Cdd:cd06173  293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGAL 372
                        170
                 ....*....|.
gi 644352050 182 MALYAAFTFLI 192
Cdd:cd06173  373 LLLAALLLLLL 383
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
23-428 1.55e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.22  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  23 ALSLGVALHAINILVATTILPSVVQDIGGLDLY-AWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCA 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLvGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 102 LAP-----SMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFG 176
Cdd:cd06173   83 LLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 177 ILLPIMALYAAFTFLILPKGKAQQAAAPLPTAQlllltvavlvvsagslahsawinlagialSLVLMAWLLKreahsrar 256
Cdd:cd06173  163 INALSFLLSALLLLFIRRPPPAAPGESSSLLLR-----------------------------DLREGLRYLR-------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 257 llphgalRRGSSLAALYITTALLVIGMTSEIFVPYFLQLLHGQSPLISGYIAAAMAAGWTLSEILSSGWRGAGIRRAIVS 336
Cdd:cd06173  206 -------RSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 337 GPLFVLVGLLALAILMPMpsgghwqaLAPIVIALLLVGFGIGFGWPHLLTRILQVAPEADKDIAGASITTVQLFATAFGA 416
Cdd:cd06173  279 IGALLLGLALLVLGLSPS--------LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
                        410
                 ....*....|..
gi 644352050 417 ALAGMIANLAGL 428
Cdd:cd06173  351 LLAGLLADALGL 362
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
36-166 2.47e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  36 LVATTILPSVVQDIG-GLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAP--SMPVMLIG 112
Cdd:COG2211  246 LVAALLLYYFKYVLGlSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVL 325
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 113 RTVQGFGGGLIFALSYAMINLVFEQRLW---PRAMALISAMWGIATLVGPAVGGIFA 166
Cdd:COG2211  326 AALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGLYFGIFTFAIKLGQALAGALA 382
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
42-188 2.89e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.03  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  42 LPSVVQDIGGLD--LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFG 119
Cdd:cd17473  220 LPFLLQERGGGSaaLIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLG 299
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644352050 120 GGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELN-----AWRWAFGILLPIMALYAAF 188
Cdd:cd17473  300 FGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgglsgAFLILGVLALVLAIVLLLL 373
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
67-191 4.15e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 45.78  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  67 ILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLwPRAMAL 146
Cdd:cd17333   45 LIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESS-ATRLNV 123
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 644352050 147 ISAMWGIATLVGPAVGGIF-AELNAWRWAFGILLPIMALYAAFTFL 191
Cdd:cd17333  124 LHGFFGLGALIGPLIATSLlTSELSWSWAYLIIGLIYLLLAILILL 169
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
66-122 4.54e-05

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 45.47  E-value: 4.54e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050  66 SILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGL 122
Cdd:cd17437   45 SLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGF 101
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
55-124 5.80e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 45.26  E-value: 5.80e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  55 YAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIF 124
Cdd:cd17358   43 FSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAAS 112
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
42-199 8.60e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 8.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  42 LPSVVQDIGGLD--LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFG 119
Cdd:COG0738  233 LPLYLKDVLGLSeaTAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 120 GGLIFALSYAMINLVFEQRLwPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLILPKGKAQ 199
Cdd:COG0738  313 LSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
Sugar_tr pfam00083
Sugar (and other) transporter;
54-192 1.26e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 44.19  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   54 LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAP---SMPVMLIGRTVQGFGGGLIFALSYAM 130
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMY 126
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644352050  131 INLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNA---WRWAFGILLPIMALYAAFTFLI 192
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNsdgWRIPLGLQLVPALLLIIGLLFL 191
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
81-204 2.25e-04

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 43.66  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  81 GARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPA 160
Cdd:PRK15403  79 GRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPL 158
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 644352050 161 VGGIFAELNAWRWAFGIlLPIMALYAAFTFLILPKGKAQQAAAP 204
Cdd:PRK15403 159 SGAALMHFVHWKVLFAI-IAVMGLIAFVGLLLAMPETVKRGAVP 201
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
59-122 2.31e-04

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 43.39  E-value: 2.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644352050  59 TTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGL 122
Cdd:cd17361   57 TSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGF 120
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
57-177 2.85e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.94  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  57 WNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFE 136
Cdd:cd17359   40 LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAP 119
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 644352050 137 QRLWPRAMAL--------ISAMWGIATLVGPAVGGIFAELNAWRWAFGI 177
Cdd:cd17359  120 AEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAEGWRWMLGL 168
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
55-192 3.01e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.92  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  55 YAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTV-QGFGGGLIFALSYAMINL 133
Cdd:cd17352   40 IAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVlGGLGLGLIYSPAIVIVGQ 119
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 644352050 134 VFEQRLwPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAFTFLI 192
Cdd:cd17352  120 YFEKKR-GLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL 177
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
56-195 4.47e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 42.18  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  56 AWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVF 135
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644352050 136 EQRLWPRAMALISAMWGIATLVGPAVGGIFaelNAWRW-AFGILLPimALYAAFTFLILPK 195
Cdd:cd17317  108 GPKYRSFVGILFGLFWALGYMLLALLAYLI---RDWRWlQLAISLP--GLLFLLLLWWLPR 163
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
26-185 4.85e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.29  E-value: 4.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  26 LGVALHAINILVATTILPSVVQDiGGLDLY--AWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALA 103
Cdd:cd17371    6 LGWALDGFDLLLLGLVLPALIAE-FGLDEAeaGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050 104 PSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMW----GIATLVGPAVGGIFAELNAWRWAF--GI 177
Cdd:cd17371   85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWavgwLLATLLAALLFPLLPPEIAWRVLFllGA 164

                 ....*...
gi 644352050 178 LLPIMALY 185
Cdd:cd17371  165 LPALLVLF 172
PRK03893 PRK03893
putative sialic acid transporter; Provisional
8-185 5.38e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 42.38  E-value: 5.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   8 RWSDLFSGKNAASAIALSLGVALHAINILVATTILPSVVQDIGgldlyawnTTLFVVASILGSALSARLLSG-------- 79
Cdd:PRK03893   9 PWYRHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFG--------LTTVQAASLISAAFISRWFGGlllgamgd 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  80 -YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMinlVFEQrlWPRAM------ALISAmWG 152
Cdd:PRK03893  81 rYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATY---VIES--WPKHLrnkasgFLISG-FS 154
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 644352050 153 IATLVGPAVGGIFAELNAWRWAF--GILLPIMALY 185
Cdd:PRK03893 155 IGAVVAAQVYSLVVPVWGWRALFfiGILPIIFALW 189
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
49-164 1.21e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 41.14  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   49 IGGLDLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAP--SMPVMLIGRTVQGFGGGLIFAL 126
Cdd:pfam13347 255 LGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFL 334
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 644352050  127 SYAMINLVFEQRLW---PRAMALISAMWGIATLVGPAVGGI 164
Cdd:pfam13347 335 PWSMLADVVDYGELrtgKRREGTFFAMWSFISKLATGVGLG 375
emrD PRK11652
multidrug transporter EmrD;
80-200 2.00e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 40.28  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  80 YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGP 159
Cdd:PRK11652  70 VGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAP 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 644352050 160 AVGGIFAELNAWR--WAFGILLPIMALYAAFTFLI--LPKGKAQQ 200
Cdd:PRK11652 150 LIGGLLTTLFGWRacYLFLLLLGAGVTFSMARWMPetRPADARRT 194
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
7-191 2.47e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   7 SRWSDLFS-GKNAASAIALSLGVALHAINILVATTILPSVVQDIGGLD-LYAWNTTLFVVASILGSALSARLLSGYGARS 84
Cdd:cd17490  182 TELKELLSvLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSfQLGLLSIIYLLPNALASLLSGTLFYKKLGER 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  85 AYLVASLFFIAGAA-LCALAPSMPVMLIGRTVQGFGGGLIFAL--SYAMINLVFEQRlwPRAMALISAMWGIATLVGPAV 161
Cdd:cd17490  262 NTIIIGFLLLGAYCfLIPFAPNLTLLYLLQALNGFGTGILFPLlmSLSIEGVPAEQR--STAMGFFQAIYALGMFLGPVL 339
                        170       180       190
                 ....*....|....*....|....*....|
gi 644352050 162 GGIFAELNAWRWAFGILLPIMALYAAFTFL 191
Cdd:cd17490  340 VGIISEAFGLQTGFFVIGVIALLAAILSLA 369
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
19-192 2.96e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.04  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   19 ASAIALSLGVALHAINILVATTILPSVVQDIGGLDlyawNTTLFVVASILGSALS----ARLLSGYGARSAYLVASLFFI 94
Cdd:pfam06609  44 ASFAAFSLNVCATYFVLQASASALPNILQDIGQSE----NQGLFSTLWTMGQAVSilmmGRLTDRFGRRPFVIATHIIGL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   95 AGAALCALAPSMPVMLIGRTVQGFGGGLIFAlSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWA 174
Cdd:pfam06609 120 VGAIVGCTANKFNTLLAAMTLLGVAAGPAGA-SPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWI 198
                         170
                  ....*....|....*...
gi 644352050  175 FGILLpIMALYAAFTFLI 192
Cdd:pfam06609 199 FYIYI-IMSAIAVLLIII 215
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
61-166 3.65e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 39.50  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  61 LFVVASILGSALSARLLSGYGARSA-----YLVASLFFIAGAALCALAPSMP-----VMLIGRTVQGFGGGLIFAL-SYA 129
Cdd:cd17326   40 WVVAAYSLGQLVFSPVFGYWSNKTSsvkepLIVSILIAIVGNILYALAEYFPsnrkyVMLVARFLIGVGAGNVAVLrAYV 119
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 644352050 130 MINLVFEQRlwPRAMALISAMWGIATLVGPAVGGIFA 166
Cdd:cd17326  120 AAASTLKDR--TRAMAVISAAQALGFIVGPALQAAFT 154
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
80-194 4.00e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 39.51  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  80 YGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGP 159
Cdd:PRK11102  53 FGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAP 132
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 644352050 160 AVGGIFAELNAWRWAFGILLPIMALYAAFTFLILP 194
Cdd:PRK11102 133 IIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
61-188 4.38e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 39.16  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  61 LFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVfEQRLW 140
Cdd:cd17393  243 VFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGAL-PGLAA 321
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 644352050 141 PRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLPIMALYAAF 188
Cdd:cd17393  322 GIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALL 369
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
50-170 4.53e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.16  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  50 GGLDLYAWNTTLFVVASILGsALSARllsgYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGlIFALSYA 129
Cdd:cd17388   40 YGVLLALYALMQFIFAPILG-ALSDR----FGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGA-TGAVAAA 113
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 644352050 130 MINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNA 170
Cdd:cd17388  114 YIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISP 154
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
54-202 7.31e-03

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 38.86  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050   54 LYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAP---SMPVMLIGRTVQGFGGGLIFALSYAM 130
Cdd:TIGR00879  72 LWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMY 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  131 INLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELN---AWRWAFGILLPIMALYAAFTFLI-------LPKGKAQQ 200
Cdd:TIGR00879 152 LSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNntlGWRIPLGLQLIPAGLLFLGLFFLpesprwlVGKGRVEE 231

                  ..
gi 644352050  201 AA 202
Cdd:TIGR00879 232 AR 233
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
62-209 7.86e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 38.37  E-value: 7.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  62 FVVASILGSALSARllsgyGARSAYLVASLFFIAGA-ALCALAPSMPVMLIGRTVQGFGGGLIFALSYAMINLVFEQRLW 140
Cdd:cd17328   47 YMVLSPIFGYLGDR-----YNRKWILAVGILIWSAAtLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKR 121
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 644352050 141 PRAMALISAMWGIATLVGPAVGGIFAELNA-WRWAFGILLPIMALYAAFTFLIL---PKGKAQQAAAPLPTAQ 209
Cdd:cd17328  122 TRALGVFYFAIPLGSGLGYVVGGLVAQATGgWRWAFRVTGVLGVLLAILLLLFVrepPRGAAEGGVMAKSTAT 194
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
39-193 8.01e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.36  E-value: 8.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  39 TTILPSVVQDIGGL--DLYAWNTTLFVVASILGSALSARLLSGYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQ 116
Cdd:cd17329  220 ESTLPVYVVEILGLgeSLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVL 299
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644352050 117 GFGGGLIFALSYAMINLVFEQRLWPRAMALISAMWGIATLVGPAVGGIFAELNAWRWAFGILLpIMALYAAFTFLIL 193
Cdd:cd17329  300 TLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILA-ALGLIAAALLLGL 375
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
47-191 9.14e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 38.40  E-value: 9.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  47 QDIGGLDLyAWNTTL--FVVASILGSALSARLLSGYGARSAYLVASLFFIAGAAL--CALAPSMPVMLI-GRTVQGFGGG 121
Cdd:cd17357   42 LSDSELDL-LWSLIVsiFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLmfLSKSAKSPELLIfGRFLVGIACG 120
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644352050 122 LIFALSyaminLVFEQRLWPRAM-ALISAMWGIATLVGPAVGGIFA------ELNAWRWAFGI-LLPIMALYAAFTFL 191
Cdd:cd17357  121 LSTGFV-----PMYLQEISPSELrGALGSLTQIGVTLGILLGQVFGlpsvlgTETLWPYLLFFpGIPALLQLAALPFF 193
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
62-166 9.60e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 38.41  E-value: 9.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644352050  62 FVVASILGsALSARllsgYGARSAYLVASLFFIAGAALCALAPSMPVMLIGRTVQGFGGGLIfALSYAMINLVFEQRLWP 141
Cdd:cd17389   78 FLSSPITG-AASDV----YGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNV-SLSTAIVADVTSPKKRS 151
                         90       100
                 ....*....|....*....|....*
gi 644352050 142 RAMALISAMWGIATLVGPAVGGIFA 166
Cdd:cd17389  152 KGMALIGVAFSLGFIIGPMIGAYFA 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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