|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
28-397 |
7.76e-106 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 316.81 E-value: 7.76e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 28 ISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSV 107
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 108 ASTFPLVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYgkGNVAWFTLAALL 187
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF--GGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 188 AIVVLLQVSKWYQHQHRATKGLPKSPSvlKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKfGVSVQNAQIH 267
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSS--ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR-GYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 268 LFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSAILVYAQELIPGKV 347
Cdd:cd17478 236 LSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 644350593 348 GMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITAL 397
Cdd:cd17478 316 GLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-344 |
4.83e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 121.23 E-value: 4.83e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 15 SAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIG 94
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 95 MGFTLSGLLLLSVASTFPLVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPY 173
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 174 GKGNVawFTLAALLAIVVLLQVSKWYQHQHRATKGlPKSPSVLKPLPKRTVAyslgILLVLIFSKYFYLASISSYYTFYL 253
Cdd:COG2814 162 GWRWV--FLVNAVLALLALLLLLRLLPESRPAARA-RLRGSLRELLRRPRLL----LLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 254 IHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWT-GILTVIIGVILASAF 332
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLlLLALFLLGFGFGLLF 314
|
330
....*....|..
gi 644350593 333 SAILVYAQELIP 344
Cdd:COG2814 315 PLLQALVAELAP 326
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-398 |
5.76e-30 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 118.82 E-value: 5.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 15 SAVKGTAFSILGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIG 94
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 95 MGFTLSGLLLLSVASTFPLVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPY 173
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 174 GkgnvaWFTLAALLAIVVLLqvskwyqhqhratkglpkspsvlkplpkrTVAYSLGILLVLIFSKYFYLASISSYYTFYL 253
Cdd:COG2271 162 G-----WRAAFLILGLPGLL-----------------------------LALLRFWLLALAYFLVYFALYGFLTWLPTYL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 254 IHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGR--KYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILAS 330
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLpSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 644350593 331 AFSAILVYAQELIPGK-VGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:COG2271 288 AFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-398 |
8.28e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 110.36 E-value: 8.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 19 GTAFSILGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFT 98
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 99 LSGLLLLSVASTFPLVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGN 177
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIAlVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 178 VAWFTLAALLAIVVLLqvskwyqhqHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSkYFYLASISSYYTF------ 251
Cdd:COG2223 161 AFLILGILLLVVAVLA---------WLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLS-LLYFGTFGSFIGFsswlpp 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 252 YLIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYA--SLYWTGILTVIIGVILA 329
Cdd:COG2223 231 YLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLALG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644350593 330 SAFSAILVYAQELIPGK-VGMVSGLFFGFAFGMGGLGAAVLGYVADLT-SIELVYQICAFLPLIGIITALL 398
Cdd:COG2223 311 GGNGAVFALVPDIFPTKnAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-397 |
3.33e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.59 E-value: 3.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 28 ISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSV 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 108 ASTFPLVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAAL 186
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 187 LAIVVLLQVSKWY---QHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQN 263
Cdd:cd06174 161 LALLAAILLLLVVpdpPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 264 AQIHLFAFLFAVAAGTIIGGPLGDK-IGRKYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILASAFSAILVYAQE 341
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLApSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 644350593 342 LIP-GKVGMVSGLFFGFAFGMGGLGAAVLGYVADLT-SIELVYQICAFLPLIGIITAL 397
Cdd:cd06174 321 LFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-344 |
2.44e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 2.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 28 ISVSHLLNDMIQSLILAIYP-ILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLS 106
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 107 VASTFPLVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVawFTLAA 185
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA--FLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 186 LLAIVVLLQVSKWYQHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQNAQ 265
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 266 IHLFAFLFAVAAGTIIGGPLGDKIGRKYVIW----GSILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSAILVYAQE 341
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlallLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
...
gi 644350593 342 LIP 344
Cdd:pfam07690 319 LAP 321
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-398 |
3.63e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.40 E-value: 3.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 28 ISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSV 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 108 ASTFPLVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWF----T 182
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVcaalA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 183 LAALLAIVVLLQVSKwyqhqHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQ 262
Cdd:cd17325 161 LLALVLALLLLPEPR-----PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 263 NAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWT-GILTVIIGVILASAFSAILVYAQE 341
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLlLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 644350593 342 LIP-GKVGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:cd17325 316 IVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-398 |
1.06e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.83 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 24 ILGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLL 103
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 104 LLSVASTFPLVLLAAALVGTGSSVF----HPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKgNVA 179
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLdvaaNPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWH-LPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 180 WFTLAALLAIVVLLQVSKWYQHQHRATKGLPKSPSVLKPLPKRTVAyslgILLVLIFSKYFYLASISSYYTFYLIHKFGV 259
Cdd:COG0738 168 LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLL----LGGLAIFLYVGAEGAIGDWLPLYLKDVLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 260 SVQNAQIHLFAFLFAVAAGTIIGGPLGDKIG-RKYVIWGSILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSAILVY 338
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 339 AQELIPGKVGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:COG0738 324 ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
47-339 |
1.25e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.99 E-value: 1.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSS 126
Cdd:COG2807 42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 127 VFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYG-KGNVAWFTLAALLAIVVLLQVSKWYQHQHRA 205
Cdd:COG2807 122 VGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPLLRRRPAAAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 206 TKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASIssyytfylIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPL 285
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI--------LRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 644350593 286 GDKIG-RKYVIWGSILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSAILVYA 339
Cdd:COG2807 274 ADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLI 328
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
41-397 |
1.67e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.43 E-value: 1.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 41 LILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAAL 120
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 121 VGTGSSVFHPESSRVA-RMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVawFTLAALLAIVVLLQVSKWY 199
Cdd:cd17324 97 AGLAHGGFWAIAAAYAaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA--FLAIAVLALLAALLLWRLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 200 QHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFylaSISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAGT 279
Cdd:cd17324 175 PSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFF---ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 280 IIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWTGILTVII-GVILASAFSAILVYAQELIPGKVGMVSGLFFGFA 358
Cdd:cd17324 252 PLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAY 331
|
330 340 350
....*....|....*....|....*....|....*....
gi 644350593 359 FGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITAL 397
Cdd:cd17324 332 NLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
43-398 |
3.51e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 70.33 E-value: 3.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 43 LAIYpiLQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVG 122
Cdd:cd17329 22 MAIY--LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 123 TGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIapygKGNVAWFTLAALLAIVVLLQVSKWYQH 201
Cdd:cd17329 100 FGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL----LYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 202 QHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQnaqihLFAFLFAVAAGTII 281
Cdd:cd17329 176 ETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES-----LLGLLLALNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 282 GG-----PLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWTGILTVI---IGVILASAFSAILVYAqeLIP-GKVGMVSG 352
Cdd:cd17329 251 LLqfpvaRLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIvltLGEMLVFPAVQTLVAA--LAPpDKRGSYMG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 644350593 353 LFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:cd17329 329 FYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
37-394 |
6.48e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 69.57 E-value: 6.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 37 MIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLL 116
Cdd:cd17475 10 LVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 117 AAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKgnVAWFTLAALLAIVVLLQV 195
Cdd:cd17475 90 LLFLVGAGYGSVQPGGGRaIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGW--RAAFVVAGLVSILAAVLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 196 SKWYQHQHRATKGLPKSPSVLKPLpkRTVAYSLGILLVLIFSKYFYLA--SISSYYTFYLIHKFGVSVQNAQIHLFAFLF 273
Cdd:cd17475 168 WLFYREPPAASAATESASTLLRSL--KEVLRNRDVWLIAIAGALLVAPqfALLTFLLLFLHDHLGLSVVAAGALLAVAQL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 274 AVAAGTIIGGPLGDKIG----RKYVIWGSILGAAPFTLV--LPYASLYWT-GILTVIIGVILASAFSAILVYAQELIP-G 345
Cdd:cd17475 246 GGALGRIGLGRVSDRVFggrrRPVLVITAAIAAAALLVLslLSPGTPLWLlVLLLILLGLFAIGWNGLYLTLVAESAGpE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 644350593 346 KVGMVSGLFFGFAFGMGGLGAAVLGYVADLT-SIELVYQICAFLPLIGII 394
Cdd:cd17475 326 QAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAAL 375
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-335 |
1.17e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.80 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 25 LGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLL 104
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 105 LSVASTFPLVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAwFTL 183
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIApTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWA-FRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 184 AALLAIVVLLQVSKWYQHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYY------TFYLIHKF 257
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGAlafwapTFFLRAFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 258 GVSVQNAQIHLFAFLFAVAA---GTIIGGPLGDKIGRKYVIWG------SILGAAPFTLVLPYASLY--WTGILTVIIGV 326
Cdd:cd17328 240 VGDLSSADVGLIFGAITCIAgvlGVLLGGILADRLRRKTPRADplvcavGLLAAAPFLFLALVLALSnlLLAWVLLFLGE 319
|
....*....
gi 644350593 327 ILASAFSAI 335
Cdd:cd17328 320 FLLSLNWAP 328
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-333 |
2.45e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 2.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQ------PYSLPIGMGFTLSGLLL-----LSVASTFPLVL 115
Cdd:COG2211 35 YFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrrrPWILIGAIPLALSFVLLftapdLSPTGKLIYAL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 116 LAAALVGTGSSVFH-PESSRVARMASGGR-HGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTL-----AALLA 188
Cdd:COG2211 115 VTYLLLGLAYTLVNiPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLtalifAVLGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 189 IVVLLQVSKWYQHQHRATKGLPKSPSVLKPLPKRTvaysLGILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHL 268
Cdd:COG2211 195 LAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRP----FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLL 270
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644350593 269 FAFLFAVAAGTIIGGPLGDKIGRKYV-IWGSILGAAPFTL--VLPYASLYWTGILTVIIGVILASAFS 333
Cdd:COG2211 271 ALYFLAALLGAPLWPRLAKRFGKKKAfIIGLLLAALGLLLlfFLGPGNLWLLLVLAALAGIGLGAILV 338
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-344 |
8.89e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.05 E-value: 8.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 25 LGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLL 104
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 105 LSVASTFPLVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIiapygkGNVAW--- 180
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL------AAISWryp 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 181 FTLAALLAIVVLLQVSKWYQHQHRatKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGVS 260
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLPEPKE--KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 261 VQNAQIHLFAFLFAVAAGTIIGGP-LGDKIGRKYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILASAFSAILVY 338
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
....*.
gi 644350593 339 AQELIP 344
Cdd:cd17474 313 VTELAP 318
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-335 |
3.69e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.10 E-value: 3.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 27 AISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKhPQPYSLPIGMGFTLSGL--LL 104
Cdd:cd17370 3 LLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDR-TGKRKPLVILGYGLSALakPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 105 LSVASTFPLVLLAAALVGTGSSVFHPesSR---VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIApYGKGNV--- 178
Cdd:cd17370 82 LALAGSWQLVLLLRILERLGKGIRTP--PRdalLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLY-LLGGNYrti 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 179 -AWFTLAALLAIVVLLQVSKWYQHQHRATKGLPKSPsvLKPLPKRTVAYSLGILLvlifskyFYLASISSYYTFYLIHKF 257
Cdd:cd17370 159 fLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTS--LKKLPKAFWLYLLAVAL-------FALGNFSFAFLILRAQEL 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644350593 258 GVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASlywtGILTVIIGVILASAFSAI 335
Cdd:cd17370 230 GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS----SLWLLLLGFILWGLYMGA 303
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-193 |
4.02e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 4.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 25 LGAISVSHLLNDMIQSLILAIYPI-LQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLL 103
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 104 LLSVASTFPLVLLAAALVGTGSSVFHP-ESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFT 182
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|.
gi 644350593 183 LAALLAIVVLL 193
Cdd:cd17325 361 AALLLLAAVLF 371
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
77-347 |
3.16e-10 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 61.54 E-value: 3.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 77 LIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTF-------PLVLLAAALVgTGSSV---FHPESSRVARMASGGRHGL 146
Cdd:cd17367 59 LFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiwaPIILLLARLL-QGLSVggeYGTSATYLSEVAPPGRRGF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 147 AQSLFQVGGNFGSSLGPLLAALIIAPYGKGNV---AW---FTLAALLAIVVL-----LQVSkwyQHQHRATKGLPKSPSV 215
Cdd:cd17367 138 YSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMaawGWripFLLGGVLAVVVLwlrrgLEET---ESFEAIAESNEASAGT 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 216 LKPLPKRTVAYSLGILLVLIFSKYFYlaSISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVI 295
Cdd:cd17367 215 LRELRRHPRELLLVVGLTAGGTLAFY--TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLL 292
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 644350593 296 WGSILGAAPFT----LVLPYASLYWTGILTVIIGVILASAFSAIL-VYAQELIPGKV 347
Cdd:cd17367 293 LFFGIGGTLATvpllSALDHTDSPYTAFALVLVGLVFLSGYTSINaVVKAELFPTHV 349
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-398 |
5.62e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 5.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 41 LILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAAL 120
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 121 VGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLA-ALLAIVVLLQVSKW 198
Cdd:cd17489 94 HGIGWGAFTTAAATlVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVlALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 199 YQHQHRATKGLPKSPSVLKplpkRTVAYSLGILLVLIFSKYfylASISSYYTFYLIHKFgvsvqnaqIHLFAFLFAVAAG 278
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLV----EKKVLPPALILFLASIAY---GAISTFLPLYAAERG--------ISNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 279 TIIG-----GPLGDKIGRKYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILASAFSAILVYA-QELIPGKVGMVS 351
Cdd:cd17489 239 ALLLsrpfsGKLSDRKGPKTVIIPGLLLLALGLLLLSFAgSPWMLLLAAVLYGLGFGLLFPALQALAvDLVPPHRRGAAN 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 644350593 352 GLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-398 |
1.96e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 58.87 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 33 LLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFP 112
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 113 LVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAW---FTLAALLAI 189
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYliiGLIYLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 190 VVLLQVSKWYQHqhratKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLA--SISSYYTFYLIHKFGVSVQNAQIH 267
Cdd:cd17333 166 LILLTLFPELPS-----ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAetAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 268 LFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILASAFSAILVYAQELIPGK 346
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLApTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 644350593 347 VGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-398 |
2.67e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.40 E-value: 2.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 58 VQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSL---PIGMGFTLSGLLLLSVAS--TFPLVLLAAALVGTGSSVFHP-E 131
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLilaDLLRALLAAVLALLALLGslSLWLLLVLAFLLGIASAFFGPaR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 132 SSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFT-LAALLAIVVLLQVSKWYQHQHRATKGLP 210
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINaLSFLLSALLLLFIRRPPPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 211 KSPSV--LKPLPKRTVAYSLGILLVLIFskyFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDK 288
Cdd:cd06173 194 LRDLRegLRYLRRSPLLRLLLLALALFA---LLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 289 IGRKYVIWGSILGAAPFTLVLPYASLYW-TGILTVIIGVILASAFSAILVYAQELIPGKV-GMVSGLFFGFAFGMGGLGA 366
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWlLLAALFLLGLAGGLFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGA 350
|
330 340 350
....*....|....*....|....*....|..
gi 644350593 367 AVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:cd06173 351 LLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
30-334 |
8.13e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 56.88 E-value: 8.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 30 VSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVAS 109
Cdd:cd17341 6 LSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 110 TFPLVLLA-AALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSS----LGPLLAALIIAPYGKG--NVAWFT 182
Cdd:cd17341 86 SSYWGLLVlGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAvsqlLAPLIAGAIVFDGGFVgwRNAFFV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 183 LAALLAIVVLLQVSKWYQHQHRATKGLPKSPSVLKPLpKRTVAYSLGILLVLIFSKYfylASISSYYTFYLIHKFGVSVQ 262
Cdd:cd17341 166 PGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVL-KNYRTWILSLLYGVTFGSF---VGFSNVLPTYFKTRFGLPLV 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644350593 263 NAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSA 334
Cdd:cd17341 242 TAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGA 313
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
47-377 |
8.33e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 57.00 E-value: 8.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSS 126
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 127 VFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGkGNVAWFTLAALLAIVVLLqVSKWYQHQHRA 205
Cdd:TIGR00881 99 MGWPPCGRtVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY-SWHWVFIVPGIIAIIVSL-ICFLLLRDSPQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 206 TKGLPK-------SPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASIS------------SYYTFYLIHKFGVSVQNAQI 266
Cdd:TIGR00881 177 SCGLPPaeempneEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGyvfvyvvrtgilDWSPLYLTQEKGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 267 HLFAFLFAVAAGTIIGGPLGDKI--GRKYVI-----WGSILGAAPFTLVlPYASLYWTGILTVIIGVILASAFSAILVYA 339
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKLfnGRRGPLavffmALIIVSLLVYWLN-PAANPLMDLICLFALGFLVYGPQMLIGVIA 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 644350593 340 QELIPGK-VGMVSGLFFGFAFGMGGLGAAVLGYVADLTS 377
Cdd:TIGR00881 336 SELAPKKaAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
54-394 |
2.56e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 55.25 E-value: 2.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 54 HLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPI-GMGFTLSGLLLLSVASTFPLVLLAAALVGTGSSVFHPES 132
Cdd:cd17471 28 GASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILlALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 133 SRVAR----MASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVawFTLAALLAIVVLLQVSKWYQHQHRATKG 208
Cdd:cd17471 108 FALAReyadRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGL--FLLAALLYLVVALLVLFLLPSVKPPAQK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 209 LPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISsyytFYLIHKFGVSVQnaqihLFAFLFAVAAGT-----IIGG 283
Cdd:cd17471 186 ATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMP----LYVTNELGGSES-----WVGLLFGLAAALeipimLLAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 284 PLGDKIGRKYVIWGSILGAAPFTLVLPYAslywTGILTVIIGVILASAFSAI-----LVYAQELIPGKVGMVSGLFFGFA 358
Cdd:cd17471 257 LLAKRFGKRRLLLAGFLAGVLFYLGLALA----TSLWQLIALQLLNAIFIGItaglgISYFQDLMPGQPGLATTLYSNAS 332
|
330 340 350
....*....|....*....|....*....|....*.
gi 644350593 359 FGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGII 394
Cdd:cd17471 333 RIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
103-348 |
6.13e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 54.23 E-value: 6.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 103 LLLSVASTFPLVLLAAALVGTGSSVFHPESSRVARMASGGRH-GLAQSLFQVGGNFGSSLGPLLAALIIaPYGKGNVAW- 180
Cdd:cd17371 79 LLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHrGKALGYVQSGWAVGWLLATLLAALLF-PLLPPEIAWr 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 181 --FTLAALLAIVVLL------QVSKWYQHQHRATKGlPKSPSVLKPLPKRTVAYSLGILLVLIFSkYFYLASISSYYTFY 252
Cdd:cd17371 158 vlFLLGALPALLVLFirrfvkEPPQWQAARAARRHF-ADRPSLRELFSPPLLRTTLLASLLATGA-LGGYYGITTWLPSY 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 253 LIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWTGILT--VIIGVILAS 330
Cdd:cd17371 236 LTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILIlgFPLGFFASG 315
|
250
....*....|....*...
gi 644350593 331 AFSAILVYAQELIPGKVG 348
Cdd:cd17371 316 PFSGMGAYLTELFPTAVR 333
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
41-347 |
1.53e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.99 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 41 LILAIYPILQADF--HLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAA 118
Cdd:cd17316 17 LIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 119 ALVGTGSSVFHP-ESSRVARMASGGRHGLAQSLFQVGGNFGSSLGpLLAALIIAPYGKGNVAW---FTLAALLAIVVLLq 194
Cdd:cd17316 97 FLQGIGIGGEYPgASTYVAEFAPSKRRGFALGLLQSGWALGALLA-ALVASLLIPLLSGDWGWrilFLIGALPALLALL- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 195 vskwyqhqhratkglpkspsvlkpLPKRTVaysLGILLVLIFSKYFYLasISSYYTFYLIHKFGVSVQNAQIHLFAFLFA 274
Cdd:cd17316 175 ------------------------LRRRTL---LLILLWFFISFGYYG--LTTFLPTYLQTVLGLSPATSSLYLLLISLG 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 644350593 275 VAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYA---SLYWTGILTVIIGVILASAFSAILVYAQELIPGKV 347
Cdd:cd17316 226 ALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEV 301
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
40-351 |
5.24e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 40 SLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAA 119
Cdd:cd17321 13 TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 120 LVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVVLlqvskw 198
Cdd:cd17321 93 LQGIGAAAIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 199 yqhqhratkglpkspsvlkplpkrTVAYSLGILLVLIFSkyFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAG 278
Cdd:cd17321 167 ------------------------ARTFSGAVLAAFLLG--AALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644350593 279 TIIGGPLGDKIG-RKYVIWGSILGAAPFTL--VLPYASLYWT-GILTVIIGVILASAFSAILVYA-QELIPGKVGMVS 351
Cdd:cd17321 221 APLAGRLADRFGpRLVLVAGLLLTAVGLLLlaLLGADSSVWLlLPGLVLLGLGLGLFATPLTNAAlSSVPKEKAGAAS 298
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
46-398 |
8.95e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 50.72 E-value: 8.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 46 YPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGS 125
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 126 SV----FHPESSRVARmaSGGRHGLA--QSLFQVGGNFGSSLGPLLAALIIAPYGKgnvawFTLAALLAIVVLLQVSKWY 199
Cdd:cd17393 102 GAldvaMNAQGVAVER--AYGRPIMSslHAMWSLGGLAGALLGAAAIGAGVSPGVH-----LLAAAVLLLLAALVAIRAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 200 QhQHRATKGLPKSPSVLKPLPKRTVAYSLgILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAGT 279
Cdd:cd17393 175 L-PGTGEAAEDRPDGAGKPGFLLPNRLLL-LLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 280 IIGGPLGDKIGRKYVI-WGSILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSAILVYAQELIPGKVGMVSGLFFGFA 358
Cdd:cd17393 253 LFGDRLVDRFGDVAVLrAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 644350593 359 FGMGGLGAAVLGYVADLTSIELVYqicAFLPLIGIITALL 398
Cdd:cd17393 333 YLGFLVGPPLIGFLADATGLRTAF---LVVALLALLVALL 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
47-398 |
1.04e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.26 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSS 126
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 127 VFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGkgnvaW---FTLAALLAIVVLLQVSKWYqhq 202
Cdd:cd17319 107 GFFPGAIKaLAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-----WrwaFIIEGLLGLLLAVLWWFYL--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 203 hratkglpkspsvlkplpKRTVAYSLGillvlifskyfYLASISSYYTF------YLIHKFGVSVQNAQIHLFAFLFAVA 276
Cdd:cd17319 179 ------------------RQVWGLALG-----------YFGINYALYGLltwlptYLKQARGFSLKQVGLLAAIPFLAGA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 277 AGTIIGGPLGDKI---GRKYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILASAFSAILVYAQELIPGK-VGMVS 351
Cdd:cd17319 230 IGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTtSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEaAATAG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 644350593 352 GLFFGFAFGMGGLGAAVLGYVADLT-SIELVYQICAFLPLIGIITALL 398
Cdd:cd17319 310 GLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVALLAALLVLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
252-398 |
4.15e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 252 YLIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYA-SLYWTGILTVIIGVILAS 330
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALApSLWLLLAARFLQGLGAGA 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 644350593 331 AFSAILVYAQELIPG-KVGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFLPLIGIITALL 398
Cdd:COG2814 115 LFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
231-405 |
4.50e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 4.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 231 LLVLIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYV-IWGSILGAAPFTLVL 309
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVlLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 310 PYASLYWTGILTVIIGVILASAFSAILVYAQELIPGK-VGMVSGLFFGFAFGMGGLGAAVLGYVADLTSIELVYQICAFL 388
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|....*..
gi 644350593 389 PLIGIITALLPNMEHKP 405
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES 177
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
48-334 |
7.96e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 47.68 E-value: 7.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 48 ILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVA-STFPLVLLAAALVGTGSS 126
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 127 VFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSL-----GPLLAALIIAPYGKGNVAW--------FTLAALLAIVVLL 193
Cdd:TIGR00886 107 SFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVaqfvmPPIIGSLIFGGGQPAHLAWgwafvivpAGILLLPALLIFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 194 QVSKWyqhqhratkglPKSPSVLKPLPKRTVAYSLGILLVLIFSKyFYLAS------ISSYYTFYLIHKFGVSVQNAQIH 267
Cdd:TIGR00886 187 VGADT-----------PPGKPATGKLSFKEALKVFGNRHTWILAL-LYSVTfgsflgVSSIFAMLFKDQFGLSKVQAGAY 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644350593 268 LFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLpYASLYWTGILTVIIGVILASAFSA 334
Cdd:TIGR00886 255 ASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLV-VLGLVSDGSLAAFIVLFVALFFFA 320
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-286 |
8.93e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.11 E-value: 8.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 24 ILGAISVSHLLNDMIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLL 103
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 104 LLSVASTFPLVLLAAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFT 182
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGAlALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 183 L---AALLAIVVLLQVSKWYQHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGV 259
Cdd:COG0477 175 AplgLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260
....*....|....*....|....*..
gi 644350593 260 SVQNAQIHLFAFLFAVAAGTIIGGPLG 286
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLL 281
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
37-335 |
2.23e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 37 MIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLL 116
Cdd:cd17503 10 LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLII 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 117 AAALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVVLLqv 195
Cdd:cd17503 90 FRILQGFGGGVLIPLAqTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA-- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 196 skwyqhqhratkglpkspSVLKPLPKRTVAYSLGILLVLIFskYFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAV 275
Cdd:cd17503 168 ------------------PLLDLRLFKDRNFTLGLLLSFLL--GLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLAS 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644350593 276 AAGTIIGGPLGDKIG-RKYVIWGSILGAA---PFTLVLPYASLYWTGILTVIIGVILASAFSAI 335
Cdd:cd17503 228 AILSPLVGRLLDKFGpRLLLLAGLLLLALgtlLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPL 291
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
49-311 |
6.91e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.57 E-value: 6.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 49 LQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKH-PQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSSV 127
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFgPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 128 FH-PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYG-KGNVAWFTLAALLAIVVLLQV---SKWYQHQ 202
Cdd:cd17355 109 LAaVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLlrrRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 203 HRATKGLPKSPSVLKPLPKRTVAYSLgiLLVLIFSKYFYLASISSYYTFYLIHkFGVSVQNAQIHLFAFLFAVAAGTIIG 282
Cdd:cd17355 189 RAYDDASPASPGSTLKEALRSASFWL--LALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLS 265
|
250 260
....*....|....*....|....*....
gi 644350593 283 GPLGDKIGRKYVIWGSILGAAPFTLVLPY 311
Cdd:cd17355 266 GWLGDRYSPRRLLAASYALRALGLALLLL 294
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
53-332 |
9.40e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.13 E-value: 9.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 53 FHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHP------QPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALV----- 121
Cdd:cd17332 30 LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRsrwgrfRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALItyill 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 122 GTGSSVFH-PESSRVARMA--SGGRHGLaQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVA--WFTLAALLAIVV---LL 193
Cdd:cd17332 110 DLLYTLVNiPYTALIPELTddPEERTSL-TSWRMFFATIGGLLVTVLPPPLVAYFGGGNASrgYFLTALIIGIIGiilLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 194 QVSKWYQHQHRATKGLPKSPSVLKPLpkRTVAYSLGILLVLIFSKYFYLA--SISSYYTFYLIHKFGvSVQNAQIHLFAF 271
Cdd:cd17332 189 ICFFGTRERVVPPEEEKSKLPLLKSL--KALLKNRPFLILLLAYLLYFLAfnIVNTVLVYYFKYVLG-GRAELVLLLLLI 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644350593 272 LFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTL---VLPYASLYWTGILTVIIGVILASAF 332
Cdd:cd17332 266 LSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLllfFLPPGNLVLILVLAVLAGIGYGGAN 329
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
271-346 |
1.09e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.72 E-value: 1.09e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644350593 271 FLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWT-GILTVIIGVILASAFSAILVYAQELIPGK 346
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELfLVLRFLVGVTSAGIFTVGFVLGMEIVGPK 110
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-193 |
1.44e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 48 ILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSSV 127
Cdd:cd17473 223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGL 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 644350593 128 FHPE-SSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVVLL 193
Cdd:cd17473 303 LLPTlNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIV 369
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
37-335 |
1.70e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.34 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 37 MIQSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLL 116
Cdd:cd17504 10 LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 117 AAALVGTGSSVFhPESSRVARMA-SGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGkgnvaW---FTLAALLAIVVL 192
Cdd:cd17504 90 GRALQGIGGAVF-PLAFALVREEfPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-----WrwiFWTAAPVAVLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 193 LQVskwyqhqhratkglpksPSV-LKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKFGVSVQNAqihlFAF 271
Cdd:cd17504 164 ALV-----------------PLIdLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEA----GLL 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 272 LFAVAAGTIIGGPLGDKIGRKY-----VIWGSILGAAPFTLVLPY-ASLYWTGILTVIIGVILASAFSAI 335
Cdd:cd17504 223 LLPGALVMLIAGPLAGRLIARVgprrvLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASL 292
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
47-338 |
2.36e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAA-ALVGTGS 125
Cdd:cd17353 27 PPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 126 SVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNvAWFTLAALLAIVVLLQVS------KWY 199
Cdd:cd17353 107 GIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT-TFLILGIIFLIIIVIGAFlirdppKGW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 200 QHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFS-KYFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAAG 278
Cdd:cd17353 186 VPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFlNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGG 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644350593 279 TIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWTG--ILTVIIGVILASAFSAILVY 338
Cdd:cd17353 266 RPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLfvLGVALIGFCYGGGFALFPAL 327
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
75-195 |
2.44e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 75 QPLIGYYTDKHPQPYSLPIGMG-FTLSGLLLLSVASTFPLVLLAAALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQ 152
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYAlRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAAlAARYFGARSYGTLFGLVF 341
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 644350593 153 VGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVVLLQV 195
Cdd:cd17355 342 APHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
217-346 |
5.19e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 5.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 217 KPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTfYLIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIW 296
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLA 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 644350593 297 GSILGAAPFTLVLPYASLYWTGILT-VIIGVILASAFSAILVYAQELIPGK 346
Cdd:COG2271 80 IGLLLWGLATLLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPK 130
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
272-346 |
6.67e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 6.67e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 644350593 272 LFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWT-GILTVIIGVILASAFSAILVYAQELIPGK 346
Cdd:TIGR00895 62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQlLILRFLAGLGLGGLMPNLNALVSEYAPKR 137
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
30-324 |
7.84e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.24 E-value: 7.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 30 VSHLLNDMIQSLILAI---YPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKH-PQPYSLPIGMGFTLSGLLLL 105
Cdd:cd17314 7 VSFLLSAMSTGFILSWslfYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFgPRPLMALAGIMVLAGYTYLS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 106 SVASTFPLVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAA 185
Cdd:cd17314 87 YVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 186 LLAI--VVLLQVSKWYQHQHRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFYLASISSYYTFYLIHKfgvsvqn 263
Cdd:cd17314 167 AAIVlsVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLD------- 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 644350593 264 AQIHLFAFLFAVAAGTIIGGPL----GDKIGRKYVIWG---SILGAAPFTLVLPYASLYWTGILTVII 324
Cdd:cd17314 240 APSFVTKLMSIYGLFNAFGRLLwgivADFFGGRLSTLSillTILGLGLCAFLFLLKMTPVGLVLTGSL 307
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
47-344 |
1.02e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.19 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMgFTLSGLLLLSV-ASTFPLVLLAAALVGTG- 124
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI-LLFSVFTLLCAlATNVTQLLILRFLAGLGl 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 125 SSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWF-TLAALLAIVVL----------L 193
Cdd:TIGR00895 120 GGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLLLLmrflpesidfL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 194 QVSKWYQHQHRATKGLPK---SPSVLKPLPKRTVAYSLGILLVLIFSKY---------FYLASISSYY-----TFYLIHK 256
Cdd:TIGR00895 200 VSKRPETVRRIVNAIAPQmqaEAQSALPEQKSTQGTKRSVFKALFQGKTaritvllwlLYFMLLVGVYfltnwLPKLMVE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 257 FGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAApfTLVLPYASLY-WTGILT--VIIGVILASAFS 333
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAV--FAVLVGSTLFsPTLLLLlgAIAGFFVNGGQS 357
|
330
....*....|.
gi 644350593 334 AILVYAQELIP 344
Cdd:TIGR00895 358 GLYALMALFYP 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
39-344 |
1.14e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.62 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 39 QSLILAIYPILQADFHlSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAA 118
Cdd:cd17502 12 QTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 119 ALVGTGSSVFHPESSRV-ARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLA-ALLAIVVLLqvs 196
Cdd:cd17502 91 AIQGIGGGGLMSLAFIIiADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPiGGLALALLR--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 197 kwyqhqhratkglpkspsvlkplpkrtvayslGILLVLIFSKYFYLA--SISSYYTFYLIHKFGVSVQNAQIHLFAFLFA 274
Cdd:cd17502 168 --------------------------------TILLSSIFGFLFGGAlfGLIYYLPLYFQLVLGDSATKSGVRLLPLIIG 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644350593 275 VAAGTIIGGPLGDKIGR-KYVIWGS----ILGAAPFTLVLPYASLYWTGILTVIIGVILASAFSAILVYAQELIP 344
Cdd:cd17502 216 LVIGSIISGALISKTGRyKPLIVIGtilmSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVP 290
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-346 |
1.73e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 39 QSLILAIYPILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAA 118
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 119 ALVGTGSSVFHPES-SRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIiapyGKGNVAWFTLAALLAIVVLLQVSk 197
Cdd:cd17477 92 FVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV----GTAGALPFLIAAVLLLLALVPLL- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 198 wyqhqhRATKGLPKSPSVLKPLPKRTVAYSLGILLVLIFSKYFyLASISSYYTFYLIHKfGVSVQNAQIHLFAFLFAVAA 277
Cdd:cd17477 167 ------LTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFL-EGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLL 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644350593 278 GTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYAS--LYWTGILTVIIGVILASAFSAILVYAQELIPGK 346
Cdd:cd17477 239 LQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPglPLALLVLLFLWGGAAGPLYTLALALAGDRLPGD 309
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-193 |
1.75e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.30 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 49 LQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQ----PYSLPIG--MGFTLSGLLLLSVASTFPLVLLAAALVG 122
Cdd:cd17475 225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrPVLVITAaiAAAALLVLSLLSPGTPLWLLVLLLILLG 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644350593 123 TGSSVFH-PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVVLL 193
Cdd:cd17475 305 LFAIGWNgLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
257-303 |
1.82e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 40.28 E-value: 1.82e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 644350593 257 FGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAA 303
Cdd:PRK11102 21 FGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFA 67
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
50-336 |
2.22e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 50 QADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSSVFH 129
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 130 PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFtlAALLAIVVLLQVSKWyqhqhratkgl 209
Cdd:cd17330 106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV--AAALALLNLVLVLFF----------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 210 pkspsvLKPLPKrtvayslgiLLVLIFSKYFYLASISSYYTFYLIHKFGVSVQNAQIHLFAF-LFAVAAGTIIGGPLGDK 288
Cdd:cd17330 173 ------LPPLRR---------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKR 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 644350593 289 IGRKYVIWGSILGAAPFTLVLPYAS-LYWTGILTVIIGVILASAFSAIL 336
Cdd:cd17330 238 LGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPALS 286
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
47-333 |
2.25e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQaDFHLSFVQIGMITLTYQLTASLLQPLIGYYTDK------HPQPYSLPIGMGFTLS----------GLLLLSVAST 110
Cdd:cd17313 24 PILQ-TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrigRRRPFILVGAPLAALGlilipnaadiGLALGDGPRT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 111 FPLVLLAAALVG---TGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAAL-----IIAPYGKGNVAW-F 181
Cdd:cd17313 103 WALVLFVLGIVLldfAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAIlwdhnWFGFALGGNLKVpF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 182 TLAALLAIVVLLQV--------SKWYQHQHRATKGLPKSPSVLKPLpKRTVAYSLGILLVLIFSKYFYLASISSYYTFYL 253
Cdd:cd17313 183 YIGAIILLVCVLVTlffvkeppLSPEAGEHSENPSLGEVLKSLLKL-LKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 254 -----------IHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILG-AAPFTLVLPYASLYWTGILT 321
Cdd:cd17313 262 geevyhgtsaaSSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLfAVGMALMALVHNVTVALVLF 341
|
330
....*....|..
gi 644350593 322 VIIGVILASAFS 333
Cdd:cd17313 342 ALGGIGWATINI 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
37-191 |
2.48e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 37 MIQSLILAIYpiLQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLS---VASTFPL 113
Cdd:cd17321 185 GGLLFLLPLY--LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllgADSSVWL 262
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 644350593 114 VLLAAALVGTGSSVFHPESSRVARMASG-GRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVV 191
Cdd:cd17321 263 LLPGLVLLGLGLGLFATPLTNAALSSVPkEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAA 341
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
45-193 |
2.59e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.59 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 45 IYPILQADFHLSFVQIGMIT----LTYQLTASLLQPLIGyytdKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAAL 120
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIAtanyAGYLVGALLASFLRR----RGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644350593 121 VGTGSS-VFHPESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFTLAALLAIVVLL 193
Cdd:cd06180 97 AGAASAfVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLL 170
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-346 |
2.96e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.56 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 39 QSLILAIYPILQaDFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAA 118
Cdd:cd17312 20 KNFSVAKPPIVE-EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 119 ALVGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVawFTLAALLAIVVLLqVSK 197
Cdd:cd17312 99 GLNGLFQSMGWPPCVKlLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA--FLVPGIVGLVVAI-ILF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 198 WYQHQHratkglpkspsvlkplPKRTVAYSLGILLVlifskYFYLASISSYYTFYLIHKFGVSVQNAQIHLFAFLFAVAA 277
Cdd:cd17312 176 FFLRDS----------------PPYVWVLSLAYAFV-----YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIA 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 644350593 278 GTIIGGPLGDKI--GRKYVIWGSILGAAPFTLVLPY---ASLYWTGILTVIIGVILASAFSAILVYAQELIPGK 346
Cdd:cd17312 235 GTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWffpHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRK 308
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
253-346 |
2.96e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 253 LIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWT-GILTVIIGVILASA 331
Cdd:cd17371 25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQlLILRALAGLGFGGE 104
|
90
....*....|....*
gi 644350593 332 FSAILVYAQELIPGK 346
Cdd:cd17371 105 WAAGAALMAEYVPAR 119
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
253-346 |
3.32e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.11 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 253 LIHKFGVSVQNAQIHLFAFLFAVAAGTIIGGPLGDKIGRKYVIWGSILGAAPFTLVLPYASLYWT-GILTVIIGVILASA 331
Cdd:cd17365 25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQlALLRFLTGLGLGAA 104
|
90
....*....|....*
gi 644350593 332 FSAILVYAQELIPGK 346
Cdd:cd17365 105 MPNAITLVSEYAPAR 119
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
77-316 |
6.41e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.51 E-value: 6.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 77 LIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFP--------LVLLAAALVGTGSSV-FHPESSRVARMASGGRHGLA 147
Cdd:cd17368 59 VLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGeVGGVTAYLVEAAPPGRRGFY 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 148 QSLFQVGGNFGSSLGPLLAALIIAPYGKGNVA-WFTLAALLAIVVLLQVSKWY-----------QHQHRATKGLPKSpsv 215
Cdd:cd17368 139 TSWQSASQQVAIVAGALVGYLLSLTLTAEALAeWGWRIPFFIGLLIIPLGLWLrrsleeteaflERKARPTRRELFA--- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 216 LKPLPKRTVAYSLGILLVLIFSKYFylasISSYYTFYLIHKFGVSvqnAQIHLFAFLFAVAAGTI---IGGPLGDKIGRK 292
Cdd:cd17368 216 LLANNRRIILLGMLLVAGSTVTFYF----TTVYTPTYAKTVLGLS---ARDSFLVTLLAGVANFIwapLGGALSDRIGRR 288
|
250 260
....*....|....*....|....
gi 644350593 293 YVIWGSILGAapftLVLPYASLYW 316
Cdd:cd17368 289 PVLLVITLAA----LVTLYPVFAW 308
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-191 |
6.99e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.38 E-value: 6.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 47 PILQADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGftLSGLL------LLSVASTFPLVLLAAAL 120
Cdd:cd17345 27 PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLI--LSAIIniligfVPSATSSVGLMFILLFL 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 644350593 121 VGTGSSVFHPESSR-VARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAW-FTLAALLAIVV 191
Cdd:cd17345 105 NGWFQGMGWPPSGRtMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGaFIFPAIIAIIV 177
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
51-193 |
8.38e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 8.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 51 ADFHLSFVQIGMITLTYQLTASLLQPLIGYYTDKHPQPYSLPIGMGFTLSGLLLLSVASTFPLVLLAAALVGTGSSVFH- 129
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQEs 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644350593 130 PESSRVARMASGGRHGLAQSLFQVGGNFGSSLGPLLAALIIAPYGKGNVAWFT-LAALLAIVVLL 193
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSaVLALIALLLLL 371
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
79-204 |
9.05e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 37.94 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644350593 79 GYYTDKHP-QPYSLPIGMGFTLSGLLLLSVAS-TFPLVLLAAALVGTGSSVFHPE-SSRVARMASGGRHGL--AQSLFQV 153
Cdd:cd17346 61 GWLADKVLgARRTVFIGGILMALGYLLLALSPfSVSMLYLGLALIIVGNGLFKPNiSSLVGKLYDENDPRRdsGFSIFYM 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 644350593 154 GGNFGSSLGPLLAALIIAPYGKGNVawFTLAA---LLAIVVLLQVSKWYQHQHR 204
Cdd:cd17346 141 GINLGAFLAPLLCGTLGDNYGYHYG--FGLAAvgmLLGLLIFLLGRKKLLERKK 192
|
|
| |
