|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-383 |
3.41e-71 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 227.10 E-value: 3.41e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 9 LWAAGGAWLFDAMDVGLLSFVIAALAKE--WHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGN 86
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 87 GLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIP----NWGWRV 162
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 163 VLLITSLPAVYTLVLrehvkdshepatiqkplpfmqrvtklwqpayRQKTALLWFVWFLVVFSYYGMFLWLPSVMV-LKG 241
Cdd:cd17316 161 LFLIGALPALLALLL-------------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQtVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 242 FSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTA--QSVGLLISAGALLSFFNLGAWGAL 319
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGAL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 320 YAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVL 383
Cdd:cd17316 290 YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-387 |
4.46e-58 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 193.19 E-value: 4.46e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI 96
Cdd:cd17365 9 VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 97 VFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLV 176
Cdd:cd17365 89 QLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 177 LrehvkdshepatiqkplpfmqrvtkLWQpayrqkTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTL 256
Cdd:cd17365 169 L-------------------------LRG------TLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 257 AQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGT-AQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSG 335
Cdd:cd17365 218 GGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVsPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATG 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 640586472 336 SGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLFGV 387
Cdd:cd17365 298 VGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
9-389 |
1.33e-57 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 192.90 E-value: 1.33e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 9 LWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGL 88
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 89 SALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIP----NWGWRVVL 164
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 165 LITSLPAVYTLVLREHVKDSHEPATIQKPLPFMQRVTKLW---QPAYRqKTALLWFVWFLVV-FSYYGMFLWLPSVMVL- 239
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRelfSPPLL-RTTLLASLLATGAlGGYYGITTWLPSYLTGe 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 240 KGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAIS--AYFFGTAqSVGLLISAGALLSFFNLGAWG 317
Cdd:cd17371 240 RGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISilLYFFLPL-SPTLILILGFPLGFFASGPFS 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640586472 318 ALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLInQKVSITVIFTIFTVAILMAAGAVLLFGVET 389
Cdd:cd17371 319 GMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA-TSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-358 |
2.39e-57 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 192.57 E-value: 2.39e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI 96
Cdd:TIGR00895 27 LMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 97 VFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLI-TSLPAVYTL 175
Cdd:TIGR00895 107 QLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 176 VLREHVKDSHEPATIQKPLPFMQRVTK-----------------------------LWQPAYRQKTALLWFVWFLVVFSY 226
Cdd:TIGR00895 187 LLMRFLPESIDFLVSKRPETVRRIVNAiapqmqaeaqsalpeqkstqgtkrsvfkaLFQGKTARITVLLWLLYFMLLVGV 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 227 YGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKwVLGSFLIGTAISAYF-FGTAQSVGLLISAG 305
Cdd:TIGR00895 267 YFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-VTALLLLLGAVFAVLvGSTLFSPTLLLLLG 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 640586472 306 ALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLI 358
Cdd:TIGR00895 346 AIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-389 |
9.60e-55 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 184.69 E-value: 9.60e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 2 TKEHHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLL 81
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 82 FSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWR 161
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 162 VVLLITSLPAVYTLVLRehvkdshepatiqkplpfmqrvtklwqpayrqkTALLWFVWFLVVFSYYGMFLWLPSVMV-LK 240
Cdd:COG2271 165 AAFLILGLPGLLLALLR---------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVeVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 241 GFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGR--KWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGA 318
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGL 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 640586472 319 LYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLInQKVSITVIFTIFTVAILMAAGAVLLFGVET 389
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL-DATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
9-385 |
3.73e-47 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 168.27 E-value: 3.73e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 9 LWAAGGAWLFDAMDVGLLSFVI--AALAKEWHL---NSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFS 83
Cdd:TIGR00898 89 LSDLGLAATEPCLDGWEYSYDTfsSTIVTEWDLvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTA 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 84 IGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPnwgWRVV 163
Cdd:TIGR00898 169 VSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 164 LLITSLPAVYTLVLREHVKDS--------------------------HEPATIQKPLPFMQRVTKLWQPAY--------- 208
Cdd:TIGR00898 246 QLAVSLPTFLFFLLSWFVPESprwlisqgrieealkilqriakingkKLPAEVLSLSLEKDLSSSKKQYSFldlfrtpnl 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 209 RQKTALLWFVWFLVVFSYYGMFLWLPSVmvlkGFSLVNSFgyvLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAIS 288
Cdd:TIGR00898 326 RKTTLCLMMLWFTTAFSYYGLVLDLGNL----GGNIYLDL---FISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVA 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 289 AYF-FGTAQSVGLLISAGALLS-FFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVgYLINQKVSITV 366
Cdd:TIGR00898 399 LLLlLFVPVDLYFLRTALAVLGkFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV-YLGEKWLFLPL 477
|
410
....*....|....*....
gi 640586472 367 IftIFTVAILMAAGAVLLF 385
Cdd:TIGR00898 478 V--LFGGLALLAGILTLFL 494
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
12-385 |
3.33e-46 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 162.32 E-value: 3.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 12 AGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSAL 91
Cdd:cd17372 4 AGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 92 SPSLIVFMALRLLVGIGLGGeLPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPA 171
Cdd:cd17372 84 APNYMWLIILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 172 VYTLVLREhvkdshepatiqkplpfmqrvtklWQPayrQKTALLWFVWFLVVFSYYGMFL-------------------- 231
Cdd:cd17372 163 SLLLVFYR------------------------WTP---KTTLLLWVIWFGNAFAYYGVVLlttelnnshnvcgsksdsds 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 232 -WLPSVMVLKGFSLVNsFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSF 310
Cdd:cd17372 216 gESPTEKQCRNSNDVD-YRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLLFGGRA 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640586472 311 FNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIftIFTVAILMAAGAVLLF 385
Cdd:cd17372 295 CISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIALL--LFSVVCLVSAICVCLL 367
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
13-381 |
2.32e-43 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 154.97 E-value: 2.32e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 13 GGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS 92
Cdd:cd17441 5 GLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 93 PSLIVFMALRLLVGIGLGGeLPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAV 172
Cdd:cd17441 85 PIYSWILVLRGLVGFGIGG-VPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 173 YTLVLREHVKDShepatiqkplpfmqrvtklwqpAYRQKTALLWFVWFLVVFSYYGMFLWL------------------- 233
Cdd:cd17441 164 IFAVLCFWLPES----------------------ARYWTTILLWFIWFSNAFSYYGLVLLTtelfqagdvcsgssgkkve 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 234 PSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLG----SFLIGTAISAYFFGTAQSVGLLISAGALLS 309
Cdd:cd17441 222 GKCSLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMAlcffVFSFCTLLLFSCVGRFSLTVLLFIARAFIS 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640586472 310 ffnlGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVifTIFTVAILMAAGA 381
Cdd:cd17441 302 ----GGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTL--SVYSGCCLLAAIA 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-385 |
2.58e-39 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 144.64 E-value: 2.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 9 LWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGL 88
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 89 SALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITS 168
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 169 LP-AVYTLVLREHVKDSHEPATIQKPLPFMQrvtkLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMV-LKGFSLVN 246
Cdd:COG2223 167 ILlLVVAVLAWLFLRDPPAGAAAAAKASLRD----QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVdQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 247 SFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAW-GALYAYTPE 325
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGnGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 326 QYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
46-385 |
5.76e-39 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 142.33 E-value: 5.76e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 46 LIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTP 125
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 126 DATRGRAVVLLESFWAAGWLAASLLAYFvIPNwgWRVVLLITSLPAVYTLVLrehvkdshepatiqkpLPFMQRvtklwq 205
Cdd:cd17317 109 PKYRSFVGILFGLFWALGYMLLALLAYL-IRD--WRWLQLAISLPGLLFLLL----------------LWWLPR------ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 206 payrqKTALLWFVWFLVVFSYYGMFLWLPSVmvlkGFSLVNSFgyvLIMTLAQLPGYFFAAWLIEKWGRKWVL-GSFLIG 284
Cdd:cd17317 164 -----RTIIVGLIWFVTSLVYYGLSLNSSNL----GGNLYLNF---FLSGLVEIPAYFLALLLLDRLGRRWTLsGSLLLA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 285 TAISAYFFGTAQSVGLLISAGALLS-FFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVgYLInqKVS 363
Cdd:cd17317 232 GLACLVTALLPDDENTLALTLALVGkFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIV-LLG--KIG 308
|
330 340
....*....|....*....|..
gi 640586472 364 ITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17317 309 PLLPLIIFGVLALLGGLLTLLL 330
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-347 |
2.36e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 140.88 E-value: 2.36e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 7 KLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGN 86
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 87 GLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLI 166
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 167 TSLPAVYTLVLREHVKDSHEPATIQKPLPFMQRVTKlwqpayRQKTALLWFVWFLVVFSYYGMFLWLPSVMV-LKGFSLV 245
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLR------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQeVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 246 NSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPE 325
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|..
gi 640586472 326 QYPAIIRGSGSGLAAAVGRIGG 347
Cdd:COG2814 324 LAPPEARGRASGLYNSAFFLGG 345
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
30-384 |
4.68e-38 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 141.64 E-value: 4.68e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 30 IAA--LAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGI 107
Cdd:PRK11551 36 VAAprMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 108 GLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSL-PAVYTLVLREHVKDSHE 186
Cdd:PRK11551 116 GLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgPLLLVPLLMRWLPESRA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 187 PATI----QKPLPFmqrVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSfGYVLIM-TLAQLPG 261
Cdd:PRK11551 196 FAQAagagKQRAPV---LRALFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQA-GLVQIAfNIGGALG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 262 YFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAA 341
Cdd:PRK11551 272 SLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVA 351
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 640586472 342 VGRIGGIVGPFLVGYLINQ-KVSITVIFTIFTVAILMAAGAVLL 384
Cdd:PRK11551 352 VGRLGSMAGPLLAGQLLALgRSTVGVIGASIPVILVAALAALLL 395
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
11-390 |
1.23e-34 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 132.02 E-value: 1.23e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 11 AAGGAWLFDAMDVGLLSFVIAALAKEW-----HLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIG 85
Cdd:cd17364 3 IAGMGFFTDAYDLFSISLVTKILGRLYyggkgSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 86 NGLSALSPSLI---VFMAL---RLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVI---- 155
Cdd:cd17364 83 TILSALSPGSTplgVMGWLiffRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSaife 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 156 ----------PNWGWRVVLLITSLPAVYTLVLREHVkdshepatiqkplpfmqrvtklwqpayrQKTALLwfvWFLVVFS 225
Cdd:cd17364 163 hplpagtyhhADLVWRIVLGLGAIPALSVLYFRKHL----------------------------LGTAGT---WFLLDIA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 226 YYGMFLWLPSVMVLKGFS---------LVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAI------SAY 290
Cdd:cd17364 212 FYGQNLFQSTIISAIGFSktmnayqelFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIfllilaGPY 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 291 FFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINqkvSITVIFTI 370
Cdd:cd17364 292 DHWKISTIGFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQ---NIGVRNVL 368
|
410 420
....*....|....*....|.
gi 640586472 371 FTVAILMAAGAVL-LFGVETM 390
Cdd:cd17364 369 IILAGVALLGIILtLLFPEEK 389
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-351 |
2.07e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 119.45 E-value: 2.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 14 GAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSP 93
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 94 SLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVY 173
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 174 TLVLREHVKDSHEPATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLI 253
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 254 MTLAQLPGYFFAAWLIEKWGRK---WVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAI 330
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
330 340
....*....|....*....|.
gi 640586472 331 IRGSGSGLAAAVGRIGGIVGP 351
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-385 |
2.81e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 2.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI 96
Cdd:cd17325 6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 97 VFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLV 176
Cdd:cd17325 86 QLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 177 LREHVKDSHEPATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVL-IMT 255
Cdd:cd17325 166 LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFgAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 256 LAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSG 335
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 640586472 336 SGLAAAVGRIGGIVGPFLVGYLInQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLY-DAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
13-385 |
1.03e-28 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 116.82 E-value: 1.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 13 GGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS 92
Cdd:cd17363 5 GLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 93 PSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWG------------- 159
Cdd:cd17363 85 QGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtayqfhs 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 160 WRVVLLITSLPAVYTLVLREHVKDS---------HEPATIQKPLPFMQRVTKLWQPAY--------RQKTALLWFVWFLV 222
Cdd:cd17363 165 WRVFVIVCALPSVASVVALTFMPESprfllevgkHDEAWMILKQVHDTNMRAKGHPERvftvshikRMNTLFLAIVWFTM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 223 VFSYYGMFLWLPSVM-----------------------VLKGFSLVNSFGY----------------------------- 250
Cdd:cd17363 245 SFSYYGLTVWFPDMIkylqfedslfeecyfedvtstntFFENCTFINTVFYntdlfeykfidsrflnstfflkekcgchl 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 251 -------------VLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYF--FGTAQSVglLISAGALLSFFNLGA 315
Cdd:cd17363 325 nddeenayliylvSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFlfFGNSESA--MIGLQCLFCGVSIAA 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 316 WGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLinqkVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17363 403 WNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSF----VGITKVIPILLASAALVCGGLLAL 468
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-383 |
6.76e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 113.29 E-value: 6.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 12 AGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSAL 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 92 SPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPN--WGWRVVLLITSL 169
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 170 PAV-YTLVLREHVKDSHEPATIQKPLPFMQRVTKLWQPAYRQK-TALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNS 247
Cdd:cd06174 161 LALlAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 248 FGYVLIMT-LAQLPGYFFAAWLIEK-WGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPE 325
Cdd:cd06174 241 AGLLLSLFgLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 640586472 326 QYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVL 383
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-385 |
1.70e-27 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 112.25 E-value: 1.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 2 TKEHHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLL 81
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 82 FSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDaTRGRAVVLLESFWAAGWLAASLLAYFVI---PNW 158
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLIllgLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 159 GWRVVLLITSLPAVYTLV------LREHVKDSHEPATIQKPLPFMQRVTKLWqpayrqktaLLWFVWFLVVFSYYGMFLW 232
Cdd:COG0738 162 SWHLPYLILAVLLLLLALlflrskLPEIEEEEEEAAGSAASLKSLLKNPRLL---------LGGLAIFLYVGAEGAIGDW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 233 LPSVMV-LKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFF 311
Cdd:COG0738 233 LPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 312 NLGAWGALYAYTPEQYPAIIRGSGSGLAAAvGRIGGIVGPFLVGYLInQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAVSAVLIM-GIVGGAIGPPLIGFLA-DAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-266 |
9.43e-27 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 108.36 E-value: 9.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 2 TKEHHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLL 81
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 82 FSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWR 161
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 162 VVLLITSLPAVYTLVLREHVKDSHEPATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKG 241
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248
|
250 260
....*....|....*....|....*
gi 640586472 242 FSLVNSFGYVLIMTLAQLPGYFFAA 266
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLA 273
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
15-384 |
9.87e-27 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 109.58 E-value: 9.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 15 AWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPS 94
Cdd:cd17319 11 AYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 95 LIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYT 174
Cdd:cd17319 91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 175 LVLrehvkdshepatiqkplpFMQRVTKLWqpayrqktaLLWFVWFLVVFSYYGMFLWLPSVMV-LKGFSLVNSFGYVLI 253
Cdd:cd17319 171 AVL------------------WWFYLRQVW---------GLALGYFGINYALYGLLTWLPTYLKqARGFSLKQVGLLAAI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 254 MTLAQLPGYFFAAWL---IEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAI 330
Cdd:cd17319 224 PFLAGAIGMILGGRLsdrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGE 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 640586472 331 IRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLL 384
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-386 |
2.36e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 109.19 E-value: 2.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 23 VGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALR 102
Cdd:COG2807 34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 103 LLVGIGLGGELPVASTLISENTPDaTRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVL----R 178
Cdd:COG2807 114 ALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLwlplL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 179 EHVKDSHEPATIQKPLPFMQRVTKLWQpayrqktalLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQ 258
Cdd:COG2807 193 RRRPAAAAAAPAAASLRSLWRSPLAWL---------LTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 259 LPGYFFAAWLIEKWGRKW-----VLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLG-AWGALYAYTPEQYPAIir 332
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRpllllLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLAlTLIGLRARTPAEAAAL-- 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 640586472 333 gsgSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLFG 386
Cdd:COG2807 342 ---SGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
13-383 |
1.18e-25 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 108.09 E-value: 1.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 13 GGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS 92
Cdd:cd17438 5 GLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 93 PSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWG------------- 159
Cdd:cd17438 85 QGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtnyhfhs 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 160 WRVVLLITSLPAVYTLVLREHVKDS--------------------HEPATIQKPLPfmqRVTKLWQPAYRQKTALLWFVW 219
Cdd:cd17438 165 WRVFVIICALPCIASIIALKFMPESprfllemgkhdeawmilkniHDTNMRAKGTP---EKVFTVSNIKRKNTLFLAVVW 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 220 FLVVFSYYGMFLWLPSVM---------------------------VLKGFSLVNSFGY---------------------- 250
Cdd:cd17438 242 FTMAFSYYGLTVWFPDMIrylqkhvtfedslfdecyfedvtstdtYFKNCTIESTIFYntdlyehkfidcrfinstfleq 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 251 -------------VLIM------TLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFF 311
Cdd:cd17438 322 kegchmdfeedndFLIYlvsflgSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGT 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640586472 312 NLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLinqkVSITVIFTIFTVAILMAAGAVL 383
Cdd:cd17438 402 SIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILGNSIFASF----VGITKVIPILLASTALVGGGLI 469
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
13-384 |
1.62e-25 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 107.69 E-value: 1.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 13 GGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS 92
Cdd:cd17440 5 GMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 93 PSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWG------------- 159
Cdd:cd17440 85 QGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsayqfhs 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 160 WRVVLLITSLPAVYTLVLREHVKDS---------HEPATIQKPLPFMQRVTKLWQPA--------YRQKTALLWFVWFLV 222
Cdd:cd17440 165 WRVFVIVCALPCVSSVVALTFMPESprfllevgkHDEAWMILKQIHDTNMRARGQPEkvftvnriKKDNTIKLTIVWLTL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 223 VFSYYGMFLWLPSVM----------------------------VLKGFSLVNSFGY------------------------ 250
Cdd:cd17440 245 SFGYYGLSVWFPDVIkhlqfksvtfedslfkscffedvtsvntYFRNCTFIETVFYntdledykfidsdfinctffhnkt 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 251 ------------------VLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYF--FGTAQSvgLLISAGALLSF 310
Cdd:cd17440 325 gcqitfdddysaywiyfvNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFlwFGTSES--MMIGMLCLYNG 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 311 FNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITViftIFTVAILMAAGAVLL 384
Cdd:cd17440 403 LTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVGITKAIPI---LLASTVLVCGGLVGL 473
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
13-383 |
3.55e-25 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 106.65 E-value: 3.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 13 GGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS 92
Cdd:cd17439 5 GLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 93 PSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGW------------ 160
Cdd:cd17439 85 QGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWsfqmgsayqfhs 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 161 -RVVLLITSLPAVYTLVLREHVKDS---------HEPA---------TIQKPLPFMQRVTKLWQpAYRQKTALLWFVWFL 221
Cdd:cd17439 165 wRVFVLVCAFPSVFAIGALTTMPESprfflengkHDEAwmvlkqvhdTNMRAKGHPERVFSVTH-IKRRITLMMMAVWFT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 222 VVFSYYGMFLWLPSVM---------------------------VLKGFSLVNS-------FGYVLIM------------- 254
Cdd:cd17439 244 MSFSYYGLTVWFPDMIkhlqksvvfedslfeecyfeditssntFFKNCTFISTlfyntdlFEYKFINsklinstflhnke 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 255 ----------------------TLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFN 312
Cdd:cd17439 324 gclldfsdennaymiyfvsflgTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVS 403
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 640586472 313 LGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPflvgYLINQKVSITVIFTIFTVAILMAAGAVL 383
Cdd:cd17439 404 IASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGI----SIFTSFVGITKAVPILLASAALAAGSSL 470
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
1-380 |
5.19e-25 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 105.78 E-value: 5.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 1 MTKEHHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLL 80
Cdd:PRK12307 12 ITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 81 LFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAvvllESFWAAGWLAASLLAYFVIPN--- 157
Cdd:PRK12307 92 AYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKA----SAFLVSGFGIGNIIAAYFMPSfae 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 158 -WGWRVVLLITSLPAVYTLVLREHVKDSHE------PATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYG-- 228
Cdd:PRK12307 168 aYGWRAAFFVGLLPVLLVIYIRARAPESKEweeaklSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGan 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 229 --MFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKwvlGSFLIGTAISAYF----FGTAQSVGLLI 302
Cdd:PRK12307 248 wpIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLK---KTFSIGLLMSFLFifplFRIPQDNYLLL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 303 SAGAL-LSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYL---INQKVSITVIFTIFTVAILMA 378
Cdd:PRK12307 325 GACLFgLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLgitMGLGAALTFIVAFWTATILLI 404
|
..
gi 640586472 379 AG 380
Cdd:PRK12307 405 IG 406
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
5-383 |
1.05e-24 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 106.21 E-value: 1.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 5 HHKLLWAA----GGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLL 80
Cdd:TIGR01299 161 HGRFQWALffvlGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLS 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 81 LFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWG- 159
Cdd:TIGR01299 241 VNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGw 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 160 ------------WRVVLLITSLPAVYTLV-----------------------LREHVKDSHEPATIQKPLPF-------- 196
Cdd:TIGR01299 321 sfqmgsayqfhsWRVFVIVCAFPCVFAIGaltfmpesprfflengkhdeawmILKLIHDTNMRAKGHPEKVFsvnhikti 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 197 --------MQRVTKLW-----------------------QPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVM-------- 237
Cdd:TIGR01299 401 hqedelieIESDTGTWyqrcfvralsegggiwgnflrcfNPEVREITIKLMGVWFTLSFGYYGLSVWFPDMIkhlqaddy 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 238 --------------VLKGFSL----------------------------------------VNSF--------------- 248
Cdd:TIGR01299 481 aaltknfpgdkvahFSFNFTLenqihrggeydndkfiglkfksvsfedslfeectfddvtsSNTFfknctfidtlfentd 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 249 ------------------------------GYVLIM--------TLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAY 290
Cdd:TIGR01299 561 feeykfidsefqncsflhnkegcpidfdgdDEGAYMiyfvnflgTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCF 640
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 291 F--FGTAQSvgLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLinqkVSITVIF 368
Cdd:TIGR01299 641 FlsFGNSES--AMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSF----VGITKAA 714
|
570
....*....|....*
gi 640586472 369 TIFTVAILMAAGAVL 383
Cdd:TIGR01299 715 PILFASAALACGGLL 729
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
8-384 |
2.83e-24 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 102.96 E-value: 2.83e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 8 LLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNG 87
Cdd:cd17442 2 LFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 88 LSALSPSLIVFMALRLLVGIGLGGElPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLIT 167
Cdd:cd17442 82 LTSFAPSYIWFVFLRCMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 168 SLPAVYTLVLrehvkdshepatiqkpLPFMQRVtklwqpayrqkTALLWFVWFLVVFSYYGMFLW-------------LP 234
Cdd:cd17442 161 SIPGIILIVV----------------FKFIPRT-----------TLQIWVIWLGISFAYYGVILAssellernllcgsDP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 235 SVMVLKGFS----------LVNSFGY--VLIMTLAQLPGYFFAAWLIEKWGRKWVLGsflIGTAISAYFF-------GTA 295
Cdd:cd17442 214 SDEEAGIKHiesespcychMFNPSDYqtMIISTLGEIALNPLNILGINFLGRRLSLV---ITMGLTAIFFlllnictSSA 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 296 QSVGLLISAGALLSF-FNLgawgaLYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINqkVSITVIFTIF-TV 373
Cdd:cd17442 291 GLTIFLFMLRALVSAnFNT-----VYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMS--ASVLGALCLFsSV 363
|
410
....*....|.
gi 640586472 374 AILMAAGAVLL 384
Cdd:cd17442 364 CIVCAISAFTL 374
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
11-388 |
2.54e-23 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 99.96 E-value: 2.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 11 AAGGAWLFdAMDVGLLSFVIAALAKE--WHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGL 88
Cdd:cd17315 2 AALGGLLF-GYDLGVINGALLYIAKDlgFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 89 SALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFV--IPNWGWRVVLLI 166
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALslSPPGWWRLMFAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 167 TSLPAVYTLVLREHVKDSHePATIQKPLPFMQRVTKlwqpayrqktallwfvwfLVVFSYYGmflwlPSVMVLKGfSLVN 246
Cdd:cd17315 161 AAVPALLQLLLMFFLPESR-ALLVGVGLQLLQQLTG------------------INAVMYYA-----PTIFKSAG-GGTA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 247 SFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVL-GSFLIGT------AISAYFFGTAQSVGLLISAGALL--SFFNLGAWG 317
Cdd:cd17315 216 SILASIIVGVVNLLATLVAIRLVDKVGRRPLLlIGFAGMAasllllAIAFLLPALAKAAGWLALLGILLyiAAFAMGAGP 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 318 ALYAYTPEQYPAIIRGSGSGLAAAVGRIGGivgpFLVGY---LINQKVSITVIFTIFTVAILMAAGAVLLFGVE 388
Cdd:cd17315 296 VPWLLLSEIFPLRIRGKGMAIATLVNWIFN----FIVGLtflIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
5-358 |
6.37e-23 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 100.19 E-value: 6.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 5 HHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEW-----HLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSL 79
Cdd:TIGR00887 14 HFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYyhgkgPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 80 LLFSIGNGLSALSP--SLIVFMAL----RLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYF 153
Cdd:TIGR00887 94 IIMIIATVASGLSPgsSPKSVMATlcfwRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 154 V---------IPNWG--------------WRVVLLITSLPAVYTLVLR---------------------------EHVKD 183
Cdd:TIGR00887 174 VlagfkhsleAAADEasctgscvpavdymWRILIGFGAVPALLALYFRltipetprytadvakdveqaasdmsavLQVKI 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 184 SHEPATIQKPLPFMQRVTKLWQPAYRQ----KTALLWF----VWFLVVFSYYGMFLWLPSVMVLKGFSLV---------- 245
Cdd:TIGR00887 254 EAEPDEVEKASTAVEVPKASWSDFFTHffkwRHGKHLLgtagSWFLLDIAFYGVNLNQKVILSAIGYSPPaatnnayeel 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 246 --NSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWV-LGSFLIGTA---ISAYFFGTAQSVGLLISAGALLSFFNLGAWGAL 319
Cdd:TIGR00887 334 ykTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIqLMGFFILTVlffVLGFAYNHLSTHGFLAIYVLAQFFANFGPNATT 413
|
410 420 430
....*....|....*....|....*....|....*....
gi 640586472 320 YAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLI 358
Cdd:TIGR00887 414 FIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLA 452
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
36-353 |
7.76e-23 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 98.13 E-value: 7.76e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 36 EWHLNSGQMGLIGSVGSIGMA---IGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGE 112
Cdd:cd17374 26 EWDLVCESQSLKSVAQSIFMAgllVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 113 LPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYfVIPNwgWRVVLLITSLPAvytlvlrehvkdshepatiqk 192
Cdd:cd17374 106 SINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAY-AIRD--WRLLQLVVSVPF--------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 193 plpFMQRVTKLWQPayrQKTALLWFVWFLVVFSYYGMflwlpsVMVLKGFSlVNSFGYVLIMTLAQLPGYFFAAWLIEKW 272
Cdd:cd17374 162 ---FLFFLYSWWLP---KRTLILSFVWFANSFSYYGL------SLDLQHLG-LNVFLLQFLFGAVEVPARCLALFLLNHM 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 273 GRKWVLGSFLI--GTAISAYFF-----GTAQSVGLLISAGALLSFFNLgawgaLYAYTPEQYPAIIRGSGSGLAAAVGRI 345
Cdd:cd17374 229 GRRISQAVLLLlaGLCILANIFvpqemQTLRTVLAVLGKGSSAAAFTI-----SYVYTAELFPTVLRQTGMGLNSMFARI 303
|
....*...
gi 640586472 346 GGIVGPFL 353
Cdd:cd17374 304 GGILAPLI 311
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
45-384 |
6.34e-22 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 95.50 E-value: 6.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 45 GLIGSVGSIGMAIGAVFFGALAD-KIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISEN 123
Cdd:cd17378 36 GLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 124 TPDATRGRAVVLLESFWAAGWLAASLLAYFVipNWGWRVVLLITSLPAVYTLVLRehvkdshepatiqkpLPFMQRVTkl 203
Cdd:cd17378 116 VGPKWRGQVGMSTFFFFVLGFMSLPGIAYLN--GSSWRVLYFWTSIPALIYCILV---------------YLFARRLL-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 204 wqpayrqktaLLWFVWFLVVFSYYGMFLWLPSVMVLKGFSlvnsfgyVLIMTLAQLPGYFFAAWLIEKWGRKWVL--GSF 281
Cdd:cd17378 177 ----------AVMVIGFGIGMVYYGIPLAVGNLKFNIYLS-------VALNALSELPAFVITAFLLDRFGRRPSLlgFTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 282 LIGTAISAYFFGTAQSVGLLISAGALLSFFNL-GAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVgyLINQ 360
Cdd:cd17378 240 LSGASCLLCFVLSIGGTTSLQIALELVGFFGAaGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIV--SLGR 317
|
330 340
....*....|....*....|....
gi 640586472 361 KVSItVIFTIFTVAILMAAGAVLL 384
Cdd:cd17378 318 KNAA-LSFGVFGVAILLLGLFALG 340
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
43-389 |
1.53e-21 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 95.80 E-value: 1.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 43 QMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSP---SLIVFMALRLLVGIGLGGELPVASTL 119
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 120 ISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVI---PNWGWRVVLLITSLPAVYTLVLREHVKDS---------HEP 187
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNktsNSDGWRIPLGLQLVPALLLIIGLLFLPESprwlvekgrLEE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 188 AT------------------IQKPLPFMQR-----VTKLWQPAYRQKTALLWFV-WFLVVFSYYGMFLWLPSVMVLK-GF 242
Cdd:pfam00083 207 ARevlaklrgvpdvdreldeIKDSLEAGQEaekasWKELFSTKTRRQRLLIGVMlQIFQQLTGINAIFYYSTTIFENlGL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 243 S--LVNSFGYVLIMTLAQlpgyFFAAWLIEKWGRKWVlgsFLIGTAISAYFFGTAQSVGLLISAGAL------------- 307
Cdd:pfam00083 287 SdsFLVTIIVGVVNFVFT----FIAIFLVDRFGRRPL---LLLGAAGMAICFVILGIVALLGVSKSDwagivaivfialf 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 308 LSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQkVSITVIFTIFTVAILMAAGAVLLFGV 387
Cdd:pfam00083 360 IAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDA-IGLGYTFFIFAGLLVLFIIFVFFFVP 438
|
..
gi 640586472 388 ET 389
Cdd:pfam00083 439 ET 440
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
32-353 |
1.58e-21 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 94.85 E-value: 1.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 32 ALAKEWHLNSGQ---MGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIG 108
Cdd:cd17377 26 SIVSEWFLVGNAaykVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVM 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 109 LGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPnwgWRVVLLITSLPAVYTLVLRehvkdshepa 188
Cdd:cd17377 106 NGGMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLS---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 189 tiqkplpfmqrVTKLWqpayrqKTALLWFVWFLVVFSYYGMFLwlpSVMVLKGFSLVNsfgyVLIMTLAQLPGYFFAAWL 268
Cdd:cd17377 173 -----------LFIPG------RTLILMYVWFVCSLVYYGLTL---NAGDLGGNIYLN----LALSGLVELPAYPLCIYL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 269 IE-KW-GRKWVLGSFLIGTAISAYFF-------GTAQSVGLLISAGALLSFFNLGA-WGALYAYTPEQYPAIIRGSGSGL 338
Cdd:cd17377 229 INqKWsGRRRTLAGFLFLGGIACLLVmfvpekkDSGVFAVVNSTSLSLLGKLTISAaFNIVYIYTSELYPTVVRNAGLGV 308
|
330
....*....|....*
gi 640586472 339 AAAVGRIGGIVGPFL 353
Cdd:cd17377 309 CSMFSRVGGIIAPFI 323
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
32-376 |
3.27e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 91.07 E-value: 3.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 32 ALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGG 111
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 112 ELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLREHVKDSHEPATIQ 191
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 192 KPLPFMQRVTKLWQPAYRqktaLLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMT-LAQLPGYFFAAWLIE 270
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLR----LAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFgVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 271 KWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAiIRGSGSGLAAAVGRIGGIVG 350
Cdd:cd17324 260 RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALG 338
|
330 340
....*....|....*....|....*.
gi 640586472 351 PFLVGYLINQKVSITVIFTIFTVAIL 376
Cdd:cd17324 339 AALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-385 |
8.93e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.94 E-value: 8.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 9 LWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGL 88
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 89 SALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFvIPNWGWR---VVLL 165
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRypfFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 166 ITSLPAVYTLVLREHVKDSHEPATiqkplpfmqRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFL---WLPSVMVLK-G 241
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSS---------SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAfltYLPFLLELLyG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 242 FSLVNSFGYVLIMTLAQLPGYFFAAWLIEK-WGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALY 320
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640586472 321 AYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLInQKVSITVIFtiFTVAILMAAGAVLLF 385
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSAPF--LVGAAIALAAAVLLA 372
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
11-385 |
3.79e-19 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 88.01 E-value: 3.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 11 AAGGAWLFdAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSA 90
Cdd:cd17359 6 AALGGLLF-GYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 91 LSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNW--------GWRV 162
Cdd:cd17359 85 FSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGgadwlgaeGWRW 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 163 VLLITSLPAVYTLVLREHVKDS-HEPATIQKPLPFMQRVTKLWQPayrqktallwFVWFLVVFsYYGmflwlPSVMVLKG 241
Cdd:cd17359 165 MLGLEAIPAILFLLGMLFIPESpRWLVSKGKPILIIGIGLAIFQQ----------FVGINVIF-YYG-----PEIFQNAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 242 FSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYA 321
Cdd:cd17359 229 FSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640586472 322 YT---------PEQYPAIIRGSGSGLAAAVGRIGGivgpFLVGYL---INQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17359 309 MSwgpvtwvllSEIFPNRIRGLAMGIAVFFLWIAN----FLVSLTfpiLLAAFGLAFTFLIFAVICVLAFLFVWKF 380
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
27-351 |
4.64e-19 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 87.48 E-value: 4.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 27 SFVIAALAKEWHLNSGQMGLIGSVGSI---GMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRL 103
Cdd:cd17447 17 STFSSTIATEWDLVCDRKGLNQATATFffaGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 104 LVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVipnWGWRVVLLITSLPAVYTLvlrehvkd 183
Cdd:cd17447 97 LTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLI---RDWRWLILAVTLPCAPGI-------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 184 shepatiqkplpfmqrVTKLWQPayrqKTALLW-FVWFLVVFSYYGMflwlpsVMVLKGFSLvNSFGYVLIMTLAQLPGY 262
Cdd:cd17447 166 ----------------ITWWWVP----KISLCTgIVWFGVAFTYYGI------SFNISGFGL-NVYLTQFIYGAIELPAK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 263 FFAAWLIEKWGRKWVLGSFLIGTAISayfFGTAQSVGLLISA-----GALLSFFNLGAWGALYAYTPEQYPAIIRGSGSG 337
Cdd:cd17447 219 LLAYLLLDRIGRRLTQAGSLILTGLS---IGINILIPSEFTVvrtviAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMG 295
|
330
....*....|....
gi 640586472 338 LAAAVGRIGGIVGP 351
Cdd:cd17447 296 YTSFIARLGGSLAP 309
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
49-351 |
2.63e-18 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 85.16 E-value: 2.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 49 SVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPdaT 128
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMP--T 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 129 RGRAVV--LLESFWAAGWLAASLLAYfVIPNWGWrvVLLITSLPAvytlvlrehvkdshepatiqkplpFMQRVTKLWQP 206
Cdd:cd17446 118 RVRAVVgtLLGYCYTLGQLILAGVAY-AIRDWRW--LQLAVSLPF------------------------FIFFLYSWWFP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 207 ayrQKTALLWFVWFLVVFSYYGMflwlpsVMVLKGFSlVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLI--G 284
Cdd:cd17446 171 ---RITFCLSLVWFSTSFAYYGL------AMDLQKFG-VSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALIlaG 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640586472 285 TAISAYFF-----GTAQSVGLLISAGALLSFFNlgawgALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGP 351
Cdd:cd17446 241 IMILANIFvpqdlQTVRTALAVFGKGCLAASFN-----CVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAP 307
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-386 |
9.10e-18 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 84.16 E-value: 9.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 25 LLSFVIAALAKEWHLNSGQM-GLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRL 103
Cdd:cd17473 17 AIAPALPAIAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 104 LVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIpNWGWRVVLLITSLP----AVYTLVLRE 179
Cdd:cd17473 97 LLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLAlpvlILVLLFLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 180 HVKDSHEPATIQKplpfMQRVTKLWQPAYrqktaLLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVL-IMTLAQ 258
Cdd:cd17473 176 PARKSKSAASPGA----ATAAALPWKRVL-----PIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALaIASLAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 259 LPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGL 338
Cdd:cd17473 247 AIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 640586472 339 AAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLFG 386
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
53-354 |
4.38e-17 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 81.72 E-value: 4.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 53 IGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRA 132
Cdd:cd17375 46 LGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 133 VVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLrehvkdshepatiqkpLPfmqrvtklwqpayrQKT 212
Cdd:cd17375 126 SMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFILCCWM----------------LP--------------KRT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 213 ALLWFVWFLVVFSYYGMFLwlpSVMVLKGfslvNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYF- 291
Cdd:cd17375 176 ITVWLIWFTGSLGYYVFSL---GSVNLGG----NEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLi 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 292 FGTAQSVGLLISAGALLSFFNLG-AWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLV 354
Cdd:cd17375 249 MVIPQDYEVLTIVLSMTGKFAIAiAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCV 312
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
1-293 |
6.12e-17 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 82.44 E-value: 6.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 1 MTKEHHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLL 80
Cdd:PRK03893 14 LNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 81 LFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGW 160
Cdd:PRK03893 94 LFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGW 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 161 RVVLLITSLPAVYTLVLREHVKDSHE-PATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVvfsyygmfLWLPsvmvl 239
Cdd:PRK03893 174 RALFFIGILPIIFALWLRKNLPEAEDwKEKHAGKAPVRTMVDILYRGEHRIINILLTLAAAAA--------LWFC----- 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 640586472 240 kgFSLVNSFGyVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFG 293
Cdd:PRK03893 241 --FAGNLQNA-AIVAVLGLLCAAIFISFMVQSSGKRWPTGVMLMVVVLFAFLYS 291
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
57-384 |
1.96e-16 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 80.26 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 57 IGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSL--------IVFMALRLLVGIGLGGELPVASTLISENTPDAT 128
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 129 RGravvLLESFWAAGWLAASLLAYFVIP------------NWGWRVVLLITSLPAVYTLVLREHVKDSHEPATIQ----- 191
Cdd:cd17369 139 RG----FYGSFPQLGAPVGLLLATGVFLllsallsdeaflSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKeagqv 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 192 KPLPFMQRVTKLWQPAyrqktallwFVWFLVVFSYYGMFlWLPSVMVL------KGFSLVNSFGYVLIMTLAQLPGYFFA 265
Cdd:cd17369 215 VRAPLVEVLRRHWRAL---------LLAIGLRLAENVLF-YLFTTFALsyatqtLGVDRSTVLLAVLIASVVAAITIPLF 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 266 AWLIEKWGRKWVLGSFLIGTAISAYFF----GTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAA 341
Cdd:cd17369 285 GWLSDRVGRRPVYLAGALLAALFAFPFfwllDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQ 364
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 640586472 342 VGRI-GGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLL 384
Cdd:cd17369 365 LGAIlGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-381 |
3.31e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.14 E-value: 3.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI 96
Cdd:cd17321 6 FLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 97 VFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLV 176
Cdd:cd17321 86 FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 177 LrehvkdshepatiqkplpfmqrvTKLWQPAYrqktallwFVWFLVVFSYYGMFLWLPSVM-VLKGFSLVNSFGYVLIMT 255
Cdd:cd17321 166 L-----------------------ARTFSGAV--------LAAFLLGAALGGLLFLLPLYLqGVLGYSPLQAGLALLPLA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 256 LAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLG---AWGALYAYTPEQYPAIIR 332
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGlglFATPLTNAALSSVPKEKA 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 640586472 333 GSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGA 381
Cdd:cd17321 295 GAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAA 343
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-383 |
5.83e-16 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 78.85 E-value: 5.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 8 LLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNG 87
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 88 LSALSPSLIVFMALR-LLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLI 166
Cdd:cd17355 84 LLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 167 ------TSLPAVYTLVLREHVKDSHEPATIQKPLPFMQRVTKLWQPAYrqkTALLWFVWFLVVFSYYGMFLWLPSVMVLK 240
Cdd:cd17355 164 lallalLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSAS---FWLLALAFFLCGFAVVGLIVHLVPYLADR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 241 GFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALY 320
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 321 AYTP-EQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVL 383
Cdd:cd17355 321 AALAaRYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-385 |
1.90e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.83 E-value: 1.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 24 GLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRL 103
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 104 LVGIGLGGELPVASTLISENTPDAtRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLREHVKD 183
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 184 SHEPATIQKPLPfmqRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYF 263
Cdd:cd17478 172 LKKPEAKKAAAK---SSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 264 FAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAgALLSFFNLGAWGALYAYTPEQYPAiIRGSGSGLAAAVG 343
Cdd:cd17478 249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPG-NVGLASGLMMGLS 326
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 640586472 344 RIGGIVGPFLVGYLINQkvsITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17478 327 FGLGGIGAPVLGALADA---FGLESVLLILALLPLLGALLAF 365
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
14-389 |
4.52e-14 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 73.05 E-value: 4.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 14 GAWLFDAmDVGLLSFVIAALA--KEWHLNSG-------QMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSI 84
Cdd:cd17356 9 GGFLFGY-DTGSISGILNMKSfqKYFADNTGtyypsssRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYII 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 85 GNGLSALS-PSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGwlaaSLLAYFVipNWG---- 159
Cdd:cd17356 88 GAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIG----ILVAYCI--NYGthkl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 160 -----WRVVLLITSLPAVYTLVLREHVKDShepatiqkplpfmqrvtklwqPAYRQKTALLWFVWFLV------VFSYYG 228
Cdd:cd17356 162 dgsaqWRIPLGLQIVWGLLLLIGMFFLPES---------------------PRWLYRTILGIMLQLFQqltginYFFYYG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 229 MFLWLPSVMVLKGFSLVNSFGYVLIMTLAqlpgyFFAAWLIEKWGRKWVLgsFLIGTAISAYFFGTA-----------QS 297
Cdd:cd17356 221 TTIFQSTGLTGSSPLLTSIILYIVNFVST-----IPGLFFVDKFGRRTCL--LIGAAGMSICLFIYAavgvrylipnpQS 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 298 VGLLISAG-------ALLSFFNLGAWGAL-YAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINqkvSITV-IF 368
Cdd:cd17356 294 GTSNKSAGngmivfiCLFIFSFATTWGPIaWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIG---SIGFkYY 370
|
410 420
....*....|....*....|.
gi 640586472 369 TIFTVAILMAAGAVLLFGVET 389
Cdd:cd17356 371 YIFAGCNLLAFIVVFFFVPET 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
20-385 |
1.32e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 71.58 E-value: 1.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 20 AMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFM 99
Cdd:cd17333 9 GLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 100 ALRLLVGIGLGGELPVASTLISENTPDaTRGRAVVLLESFWAAGWLAASLLAYFVIPN-----WGWRVVLLITSLPAVYT 174
Cdd:cd17333 89 VLMFLAGLGAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLTSelswsWAYLIIGLIYLLLAILI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 175 LVLR--EHVKDSHEPATIQKPLPFMQRvtKLWQPAYRqktaLLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVL 252
Cdd:cd17333 168 LLTLfpELPSARNPQQSVGAFSASASR--LLRNPSII----LGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 253 -IMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAiI 331
Cdd:cd17333 242 sGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPY-A 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 640586472 332 RGSGSGLAAAVGRIGGIVGPFLVGYLINQkVSITVIFTIFTvaILMAAGAVLLF 385
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFIAEA-VGIQTAMLLIT--ILYAIIFVLAL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-385 |
1.57e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.09 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI 96
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 97 VFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLV 176
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 177 LREHVKDSHEPATIQKPLPFMQRvtklwqPAYRQKTALLWFVWFLVVFSYYGMFL-WLPSVMVLKGFSlvNSFGYVLIMT 255
Cdd:cd17489 166 LVFLVKDPPPVAAEEAEAGTRAF------RRLVEKKVLPPALILFLASIAYGAIStFLPLYAAERGIS--NAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 256 LAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSG 335
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 640586472 336 SGLAAAVGRIGGIVGPFLVGYLInQKVSITVIFtIFTVAILMAAGAVLLF 385
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVA-ELFGYRAMF-LLAAVVVLLALVLYIF 365
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
23-389 |
2.90e-13 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 70.68 E-value: 2.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 23 VGLLSFVIAALAKEW----HLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVF 98
Cdd:cd17358 18 VGWSSPALPSLMSDNslslPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWML 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 99 MALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVipNWGWrVVLLITSLPAVYTLVL- 177
Cdd:cd17358 98 YLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL--PWRT-LALIGAIPPVVFLILLf 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 178 ------REHVKDSHEP-------------ATIQKPLPFMQRVTKL---------WQPAYRQKTALLWFVWFL-------- 221
Cdd:cd17358 175 fipespRWLAKKGREEeaekslqflrgkdADISKEAAEIQEELAElekeakessFSDLFQRKYLKPLVIGLGlmlfqqls 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 222 --VVFSYYGmflwlpSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVL-----GSFLIGTAISAYFFgt 294
Cdd:cd17358 255 giNAVIFYA------SSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLlvsaiGMGIGLLALGLYFY-- 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 295 AQSVGLLISAGALLSF---------FNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKvSIT 365
Cdd:cd17358 327 LQEHGALLSSVSWLPLvglviyiisFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAW-GAS 405
|
410 420
....*....|....*....|....
gi 640586472 366 VIFTIFTVAILMAAGAVLLFGVET 389
Cdd:cd17358 406 GTFWIFAGICGLALVFVLLFVPET 429
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
46-385 |
4.83e-13 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 69.88 E-value: 4.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 46 LIGSVGSIGMAIGA---VFFGALADKIGRRnsllfsLLLFSIGNGLSALSPSLIVF-------MALRLLVGIGLGGELPV 115
Cdd:cd17370 35 AVGLIEGLAEALGSllrLFSGYLSDRTGKR------KPLVILGYGLSALAKPLLALagswqlvLLLRILERLGKGIRTPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 116 ASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIP--NWGWRVVLLITSLPAVYTLVL----REHVKDSHEPAT 189
Cdd:cd17370 109 RDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYllGGNYRTIFLLAAIPALLALLIllfvVKEYPRPPKLRK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 190 IQKPLPFMQRVTKLWqpayrqktaLLWFVWFLVVFSYYG-MFLWLPSVMVLKGFSLVNSFgYVLIMTLAQLPGYFFaAWL 268
Cdd:cd17370 189 KSKKTSLKKLPKAFW---------LYLLAVALFALGNFSfAFLILRAQELGLSAALIPLL-YALFNLVYALAAYPA-GRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 269 IEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLIsAGALLSFFNLGAWGALY-AYTPEQYPAIIRGSGSGLAAAVGRIGG 347
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLL-LGFILWGLYMGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGW 336
|
330 340 350
....*....|....*....|....*....|....*...
gi 640586472 348 IVGPFLVGYLInQKVSITVIFTIftVAILMAAGAVLLF 385
Cdd:cd17370 337 LLASLIAGYLW-DLISPSAAFLF--SAVLALIALLLLL 371
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
27-354 |
2.01e-12 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 67.88 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 27 SFVIAALAKEWHL---NSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRL 103
Cdd:cd17376 17 DVYLSTIVTEWNLvceDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 104 LVGIGLGGELPVASTLISENTPDATRgravVLLES-----FWAAGWLAASLLAYFVipnWGWRVVLLITSLPAVYTLvlr 178
Cdd:cd17376 97 IVGMGQISNYVVAFVLGTEILGKSVR----ILFSTlgvciFYAIGYMLLPLFAYFI---RDWRMLLLALTLPGVLCV--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 179 ehvkdshepatiqkPLPFMQRVTklwqpayrqkTALLWFVWFLVVFSYYGMFLWLPSvmvLKGFSLVNSFgyvlIMTLAQ 258
Cdd:cd17376 167 --------------PLWWFIPIT----------TIMSLLLWMAISVGYFGLSLNTPN---LHGDPYLNCF----LSAVIE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 259 LPGYFFAAWLIEKWGRKWVLGSFL-IGTAISAYFFGTAQSVGLLISAGALLSFFNL-GAWGALYAYTPEQYPAIIRGSGS 336
Cdd:cd17376 216 VPAYIIAWLLLRSLPRRYSIAATLvLGGGVLLFIQLVPTDLQVLATALVMLGKFGItAAFSMVYVYTAELYPTVVRNMGV 295
|
330
....*....|....*...
gi 640586472 337 GLAAAVGRIGGIVGPFLV 354
Cdd:cd17376 296 GVCSTASRIGSIISPYFV 313
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
23-379 |
2.64e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 67.58 E-value: 2.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 23 VGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALR 102
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 103 LLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNwGWR---VVLLITSLPAVYTLVLRE 179
Cdd:cd17477 92 FVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALpflIAAVLLLLALVPLLLTRR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 180 HVKDSHEPATIqkplPFMQRVTKLWQPayrqktALLWFVWFLVVFSYYGMflwLPSVMVLKGFSLVNSFGYVLIMTLAQL 259
Cdd:cd17477 171 AAPEIEEAESI----SLRRLLRIAPLA------LLGAFVAGFLEGAFYSL---LPLYGLRLGLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 260 PGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLIsagALLSFFNLGAWGALY----AYTPEQYPAIIRGSG 335
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLAL---LVLLFLWGGAAGPLYtlalALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 640586472 336 SGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAA 379
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
25-385 |
2.68e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 67.64 E-value: 2.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 25 LLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLL 104
Cdd:cd17329 18 VWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 105 VGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVI---PNWGWRVVLLITSLPAVYTLVLREHV 181
Cdd:cd17329 98 TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLlysFRLLFLAAAVLFLLAALVLLFLLPET 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 182 KDSHEPATIqkplpfmQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMF-LWLPSVMVLKGFSLVNSFGYVL-IMTLAQL 259
Cdd:cd17329 178 RPKRRAAEK-------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLeSTLPVYVVEILGLGESLLGLLLaLNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 260 PGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLA 339
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 640586472 340 AAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17329 331 ALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
25-358 |
3.13e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 67.40 E-value: 3.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 25 LLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLL 104
Cdd:TIGR00881 13 NFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 105 VGIGLGGELPVASTLISENTPDATRGRAVvlleSFWA-----AGWLAASLLAYFVIPNWGWRVVLLITSLPA-----VYT 174
Cdd:TIGR00881 93 NGIFQGMGWPPCGRTVTKWFSRSERGTWV----SFWNcshnvGGGLLPPLVLFGIAELYSWHWVFIVPGIIAiivslICF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 175 LVLREHVKDSHEPATIQKPLPFMQRVTKLWQPAYRQKTALLW------------FVWFLVVFSYYGMFLWLPSVMV-LKG 241
Cdd:TIGR00881 169 LLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQyvllnkvlwyisLGYVFVYVVRTGILDWSPLYLTqEKG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 242 FSLVNSFGYVLIMTLAQLPGYFFAAWLIEKW--GRKWVLGSF---LIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAW 316
Cdd:TIGR00881 249 FSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFfmaLIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQ 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 640586472 317 GALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLI 358
Cdd:TIGR00881 329 MLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLA 370
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
39-349 |
3.69e-12 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 66.91 E-value: 3.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 39 LNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVAST 118
Cdd:cd17360 32 LSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 119 LISENTPDATRGRAVVLLESFWAAGWLAASLL-AYFVIPNWGWRVVLLITSLPAVYTLVLREHVKDSHEpatiqkplpfm 197
Cdd:cd17360 112 YIAEAAPPRIRGRLVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPESPR----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 198 qrvtklWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGF-SLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKW 276
Cdd:cd17360 181 ------WPSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFkDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRK 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 277 VLGSFLIGTAISAYFFgtaqSVGL-LISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIV 349
Cdd:cd17360 255 LLLISLFGVIVALVVL----AVWLaLVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLL 324
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
40-384 |
4.12e-12 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 66.61 E-value: 4.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 40 NSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTL 119
Cdd:cd17379 31 DAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 120 ISENTPDATRGRAVVLLESFWAAGWLAASLLAYFvIPNWGWrvVLLITSLPAVYtlvlrehvkdshepatiqkplpfmqr 199
Cdd:cd17379 111 VTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYF-IPHWRW--LQLAVTLPNFL-------------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 200 vtklwqpayrqktaLLWFVWFLVVFSYYGMFLWLPSVMVLKGfsLVNSFGYV--------LIMTLAQLPGYFFAAWLIEK 271
Cdd:cd17379 162 --------------FLLYYWFIPKHTFILMYAWFTSAVVYQG--LIMRLGITggnlyldfFISALVELPAAFIILLTIDR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 272 WGRK--WVLGSFLIGTAISAYFFgTAQSVGLLISAGALLSFFNLG-AWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGI 348
Cdd:cd17379 226 IGRRlpFAASNIVAGAACLITAF-IPPDLHWLKTTIACVGRLGITmAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGI 304
|
330 340 350
....*....|....*....|....*....|....*.
gi 640586472 349 VGPFLVGYLINQKVSITVIftIFTVAILMAAGAVLL 384
Cdd:cd17379 305 IAPFLLYRLAEIWLELPLI--VFGVLALVAGGLVLL 338
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-384 |
7.01e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 66.06 E-value: 7.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 25 LLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLL 104
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 105 VGIGlGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLrehvkds 184
Cdd:cd17504 94 QGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 185 hepatiqkpLPFMqRVTKLWQPAyrqkTALLWFVWFLVVFSYYGMFLWLPSVMVLK-----GFSLVNSFGYVLIMTLAQL 259
Cdd:cd17504 166 ---------VPLI-DLRLLRRRN----VLLANITALLAGFGMFMVFQLLPQLLQLPtptgfGLGITEAGLLLLPGALVML 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 260 PGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGT-AQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGL 338
Cdd:cd17504 232 IAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGM 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 640586472 339 AAAVGRIGGIVGPFLVGYLINQKVSITVIFTI-----FTVAILMAAGAVLL 384
Cdd:cd17504 312 NTVLRTIGSAIGPAIAGAILTTYTVSITSGGVptegaYVLAFLIGAALALA 362
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
45-385 |
1.73e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 64.91 E-value: 1.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 45 GLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIgLGGELPVASTLISENT 124
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 125 PDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLrehvkdshepatIQKPLPFMQRVtklw 204
Cdd:cd17330 116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL------------VLFFLPPLRRL---- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 205 qpayrqktALLWFVWFLVVFSYYGMF-LWLPSVMVLKGFSLVNSFGYV-LIMTLAQLpgyFFAAWLIEKWGRK--WVLGS 280
Cdd:cd17330 180 --------LLVYFLIALAFAGLESVFsLFLKDRFGFSPSQIGLLLALVgIAGILAQL---LLIPRLAKRLGERklLRLGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 281 FLIGTAISAYffGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLInq 360
Cdd:cd17330 249 LLAIIGLLLL--PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY-- 324
|
330 340
....*....|....*....|....*
gi 640586472 361 kVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17330 325 -SFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
57-342 |
1.88e-10 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 61.93 E-value: 1.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 57 IGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSL--------IVFMALRLLVGIGLGGELPVASTLISENTPDAT 128
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiwapIILLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 129 RGRAVVLLESFWAAGWLAASLLAYFV--------IPNWGWRVVLLITSLPAVYTLVLREHVKDSHEPATIQKPLPFMQRv 200
Cdd:cd17367 135 RGFYSSFQYVTLIGGQLLALGVLLVLqhtlgedqMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAG- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 201 tkLWQPAYRQKTALLWFVWFLVVFS--YYGMFLWLPSVMVLK-GFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWV 277
Cdd:cd17367 214 --TLRELRRHPRELLLVVGLTAGGTlaFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPL 291
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640586472 278 LGSFLIGTAISAYFFGTAQSVG-------LLISAGALLSFFNLGAWGALYAytpEQYPAIIRGSGSGLAAAV 342
Cdd:cd17367 292 LLFFGIGGTLATVPLLSALDHTdspytafALVLVGLVFLSGYTSINAVVKA---ELFPTHVRALGVGLPYAL 360
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
41-385 |
5.59e-10 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 60.82 E-value: 5.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 41 SGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIG---NGLSALSPSLIVFMALRLLVGIGLGGELPVAS 117
Cdd:TIGR00879 70 SSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGailMGLAAFALSVEMLIVGRVLLGIGVGIASALVP 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 118 TLISENTPDATRGRAVVLLESFWAAGWLAASLLAYF-VIPNW--GWRVVLLITSLPAVYTLVL----------------- 177
Cdd:TIGR00879 150 MYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGkVSLNNtlGWRIPLGLQLIPAGLLFLGlfflpesprwlvgkgrv 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 178 ---REHVKDSH----EPATIQKPLPF--------MQRVTKLWQPAYRQKTALLWFVWFLVVFsyyGMFLWLPSVMVLKGF 242
Cdd:TIGR00879 230 eeaRKSLARLRgtsgEDKELLDELELidikrsieKRSVQPSWGSLFSSTRRIRRRLFLGVVL---QWFQQFTGINAIMYY 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 243 SLV--NSFGYVLIMTLAQLPGY--------FFAAWLIEKWGRKWVL---------GSFLIGTAISAYFFGTAQSVGLLIS 303
Cdd:TIGR00879 307 SPTifENAGVSTDHAFLVSIIVgavnfaftFVAIFLVDRFGRRPLLligaagmaiCLFVLGILGASFVTGSSKSSGNVAI 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 304 AGALL--SFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINqkvSITVIFTIFTVAILMAAGA 381
Cdd:TIGR00879 387 VFILLfiAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLE---SIGVGGVFIFFGGLNVLGL 463
|
....
gi 640586472 382 VLLF 385
Cdd:TIGR00879 464 IFVY 467
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-169 |
7.78e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 7.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 3 KEHHKLLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLF 82
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 83 SIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRV 162
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
....*..
gi 640586472 163 VLLITSL 169
Cdd:cd06173 365 VFLLAGA 371
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
25-384 |
1.12e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 59.57 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 25 LLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGN-GLSALSPSLIVFMALRL 103
Cdd:cd17341 17 LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlALALAVSSYWGLLVLGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 104 LVGIGlGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLA-------YFVIPNWGWRVVLLITSLPAVYTLV 176
Cdd:cd17341 97 LLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLApliagaiVFDGGFVGWRNAFFVPGILLAIAAV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 177 LREHVKDSHEpatiQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPsvMVLK---GFSLVNSFGYVLI 253
Cdd:cd17341 176 LVLLFGDDLP----TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLP--TYFKtrfGLPLVTAGILAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 254 MTLAQLPGYFFAAWLIEKWG---RKWVLGSFLIGTAISAYFFGTAQSVGLLISAGA--LLSFFNLGAWGALYAYTPEQYP 328
Cdd:cd17341 250 FPLAGALARPAGGWLSDRFGgrrRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALfvALGLGAGAGNGSVFRMVPFIFR 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 640586472 329 AIIrGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLL 384
Cdd:cd17341 330 REL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
213-393 |
1.21e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.22 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 213 ALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFF 292
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 293 GTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQkVSITVIFTIFT 372
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLVNA 171
|
170 180
....*....|....*....|.
gi 640586472 373 VAILMAAGAVLLFGVETMHQK 393
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAA 192
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
22-385 |
1.30e-09 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 59.34 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 22 DVGLLSFVIAALAKEWHLNSGQMG-LIGSVGSIGMaIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMA 100
Cdd:cd17437 12 DIGVMSGAVIFIKEDLKISDVQEEvLIGSLNIISL-VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 101 LRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYF---VIPNWGWRVVLLITSLPAVYTLVL 177
Cdd:cd17437 91 GRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAfsgLPLHVGWRLMLGVGAVPSLFLAIG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 178 REHVKDSHEpatiqkplpfmqrvtklWQPAYRQK-TALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNS-FGYVLIMT 255
Cdd:cd17437 171 VLAMPESPR-----------------WTPAVRRMlIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKDKlLLATVAVG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 256 LAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTA-------------QSVGLLISAGALLSFFNLGAWGALYAY 322
Cdd:cd17437 234 VTKTLFILVATFLLDKVGRRPLLLTSTGGMTLSLTALATSltfidrngggltwALVLAITAVCSFVAFFSIGAGPITWVY 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 323 TPEQYPAIIRGSGSGLAAAVGRI-GGIVGpflVGYLINQKvSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17437 314 SSEIFPLRLRAQGASLGVVVNRLmSGTVS---MTFLSMSK-AITTGGTFFLFAGVAAAAWVFFY 373
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-385 |
1.50e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 59.21 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 25 LLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLL 104
Cdd:cd17312 21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 105 VGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLrehvkds 184
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAII------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 185 hepatiqkpLPFMQRVTK--LWqpayrqktaLLWFVWFLVVFSYYGMFLWLPSVMV-LKGFSLVNSFGYVLIMTLAQLPG 261
Cdd:cd17312 174 ---------LFFFLRDSPpyVW---------VLSLAYAFVYIVRYACLDWGPLYLYeVKGYSLIDAGWFSSLYEVGGIAG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 262 YFFAAWLIEKWG---RKWVLGSFLIGTAISAYFFGTA-QSVGLLISAGALLSFFNLGA---WGALYAYTPEQYPAIirGS 334
Cdd:cd17312 236 TILAGLLSDKLFggrRAPIAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIGFFVGGPinlIGGAAAQDIGRKEAA--GT 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 640586472 335 GSGLAAAVGRIGGIVGPFLVGYLInqkvSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17312 314 ATGFVGLFGYLGASLAGLPLGYII----DHYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
57-358 |
1.72e-09 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 58.92 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 57 IGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPS---------LIVFMAlRLLVGIGLGGELPVASTLISENTPDA 127
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTyatigiaapLLVLLA-RLLQGFAAGGEVGGVTAYLVEAAPPG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 128 TRGRAVVLLESFWAAGWLAASLLAYFV--------IPNWGWRVVLLITSLPAVYTLVLREHVKDShEPATIQKPLPFMQR 199
Cdd:cd17368 134 RRGFYTSWQSASQQVAIVAGALVGYLLsltltaeaLAEWGWRIPFFIGLLIIPLGLWLRRSLEET-EAFLERKARPTRRE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 200 VTKLWQPAYRQKT-----ALLWFVWFLVVFSYYGMFLwlpsvMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGR 274
Cdd:cd17368 213 LFALLANNRRIILlgmllVAGSTVTFYFTTVYTPTYA-----KTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGR 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 275 KWVLGSFLIGTAISAY----FFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVG-RIGGIV 349
Cdd:cd17368 288 RPVLLVITLAALVTLYpvfaWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAvAIFGGF 367
|
....*....
gi 640586472 350 GPFLVGYLI 358
Cdd:cd17368 368 AQFIVTWLI 376
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-357 |
1.97e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.79 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI 96
Cdd:cd17328 9 LLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 97 VFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVvlleSFWAAGWLAASLLAYFV---IPNW--GWRVVLLITSLPA 171
Cdd:cd17328 89 QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRAL----GVFYFAIPLGSGLGYVVgglVAQAtgGWRWAFRVTGVLG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 172 VYTLVL---------REHVKDSHEPATiqkplpfmqRVTKLWQPAY--RQKTALLWFVW--FLVVFSYYGMFLWLPSVM- 237
Cdd:cd17328 165 VLLAILlllfvreppRGAAEGGVMAKS---------TATSFLADLKalAKNPSFILSTLgfTAVSFVTGALAFWAPTFFl 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 238 ---VLKGFSLVN-SFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLI---GTAISAYFFGTA-----QSVGLLISAG 305
Cdd:cd17328 236 rafGVGDLSSADvGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVcavGLLAAAPFLFLAlvlalSNLLLAWVLL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 640586472 306 ALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGR-IGGIVGPFLVGYL 357
Cdd:cd17328 316 FLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLI 368
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-384 |
2.04e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 58.74 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 30 IAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGL 109
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 110 GGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLreHVKDSHEPAT 189
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL--VLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 190 IQKPLPFMQRVTKLWQPAYRQKTAllWFVWFLVVFSYYGMFLWL---PSVMVLKGFSLVNSFGYVLIMT-LAQLPGYFFA 265
Cdd:cd17320 180 EEKRKPLLSSLLRAYKRVLKNRRF--LGYALALGLSFAGLFAYLaaaPFIYIEQLGLSPAQFGLLFALNaIALILGSLLN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 266 AWLIEKWGRKWVLG-----SFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAiIRGSGSGLAA 340
Cdd:cd17320 258 GRLVRRFGPRRLLRlglllLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLG 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 640586472 341 AVGRIGGIVGPFLVGYLINQKVSiTVIFTIFTVAILMAAGAVLL 384
Cdd:cd17320 337 FLQFLIGALAGALVGLLPNGTAL-PMGLLILVLGLLALLLLILL 379
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
39-172 |
2.46e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 58.52 E-value: 2.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 39 LNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVAST 118
Cdd:cd17362 36 LSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPV 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 640586472 119 LISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPN-WGWRVVLLITSLPAV 172
Cdd:cd17362 116 YIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVvGGWRYMYGLAAPPAL 170
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
45-169 |
5.49e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 57.27 E-value: 5.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 45 GLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENT 124
Cdd:cd17391 243 GLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 640586472 125 PDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSL 169
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTAL 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-384 |
5.53e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 5.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 6 HKLLWAAGGAwLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIG-----RRNSLLFSLL 80
Cdd:COG2211 11 EKLAYGLGDL-GLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 81 LFSIGNGLSALSPS------LIVFMALRLLVGIGLGGELPVASTLISENTPDAT-RGRAVVLLESFWAAGWLAASLLAYF 153
Cdd:COG2211 90 PLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 154 VIPNW------GWRVVLLITSLPAVYTLVL-----REHvkdshePATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLV 222
Cdd:COG2211 170 LVAAFggdaalGYRLTALIFAVLGLLAFLLtffgtKER------PVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 223 VFSYYGMFLwlPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRK--WVLGSFLIGTAISAYFFGTAQSVGL 300
Cdd:COG2211 244 LALVAALLL--YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKkaFIIGLLLAALGLLLLFFLGPGNLWL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 301 LISAGALLSFFNLGAWGALYAYTPE-------QYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLI-------NQKVSITV 366
Cdd:COG2211 322 LLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLalfgyvaGAAQSPSA 401
|
410
....*....|....*...
gi 640586472 367 IFTIFTVAILMAAGAVLL 384
Cdd:COG2211 402 LTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
45-385 |
5.70e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 57.27 E-value: 5.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 45 GLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIgLGGELPVASTLISENT 124
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 125 PDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITS-LPAVYTLVLREHVKDSHEPATIQKPLPFMQRVTKL 203
Cdd:cd17391 118 PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGgLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 204 WQPayrqktALLWFVWFLVVFSYYGMFLWLP----SVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLiEKWGRKWVLG 279
Cdd:cd17391 198 PNP------SLLISLFVTTFIIQLANQSIEPiltlYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRL-GKLGDRIGHH 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 280 SFLIGTAISAYFFGTAQS-VGLLISAGALLSFFNLGAWGALYAYTP---EQYPAIIRGSGSGLAAAVGRIGGIVGPFLvG 355
Cdd:cd17391 271 RILLGALLASALLYIPQAfVQTPWQLGILRFLLGLATGGLLPAINSllaKITPKEVAGRIFGYNQSFQYLGNVAGPLL-G 349
|
330 340 350
....*....|....*....|....*....|
gi 640586472 356 YLINQKVSITVIFtiFTVAILMAAGAVLLF 385
Cdd:cd17391 350 SAIAAHFGYRAVF--VVTALLVLLNAIWSF 377
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
53-385 |
6.37e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.23 E-value: 6.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 53 IGMAIG------AVF---FGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGElpVASTLISEN 123
Cdd:cd17472 34 IGLALGiygltqAIFqipFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 124 TPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLREHVKDsHEPATIQKPLPFMQRVTKL 203
Cdd:cd17472 112 TREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP-DPPKIVQISEKEKKKLKKL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 204 WQpayRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKW---VLGS 280
Cdd:cd17472 191 LK---NKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKqvfVSSI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 281 FLIGTAISAYFFGTAQSVGLLISAGALLSFFNLgawgaLYAYTP----EQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGY 356
Cdd:cd17472 268 LLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNL-----LEALLPslvsKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGL 342
|
330 340
....*....|....*....|....*....
gi 640586472 357 LINQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17472 343 LWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-386 |
6.95e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 56.79 E-value: 6.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 26 LSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIgngLSALSP-----SLIVFMA 100
Cdd:cd17380 18 MPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSL---ATLLTPllaysSLPLLIL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 101 LRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVytlvlreh 180
Cdd:cd17380 95 SRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGL-------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 181 vkdshepatiqkplpfmqrvtkLWQPAYRqktALLWFVWFLVV------FSYYGMFLWLPSVMVLKGFSLVNSFGYV--- 251
Cdd:cd17380 167 ----------------------LWALVWL---IYLPPVWAIIVahfcmnWGFYILLSWLPTYFHEVLVPLAKGWVFNvvp 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 252 -LIMTLAQLPGYFFAAWLIEK-----WGRKWVLGSFLIGTAISAYFFGTAQSVG---LLISAGALLSFFNLGAWGALYAY 322
Cdd:cd17380 222 wLVMFPSSNVAGWLADHLISRgwtvtSVRKLMQSIGFLGPALFLLLLSHTDSFSlalLCMSVALGLSAFSSSGVLVNHQD 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640586472 323 TPEQYPaiirGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIftVAILMAAGAV--LLFG 386
Cdd:cd17380 302 IAPNYA----GIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVL--AAVVNLVGAVvfLLFG 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-147 |
1.36e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 8 LLWAAGGAWLFDAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNG 87
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 88 LSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAA 147
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
20-388 |
2.09e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 55.26 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 20 AMDVGLLSFVIAALAKEWHlNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFM 99
Cdd:cd17502 9 ALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 100 ALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLItSLP--AVYTLVL 177
Cdd:cd17502 88 VGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI-NLPigGLALALL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 178 REhvkdshepatiqkplpfmqrvtklwqpayrqkTALLWFVWFLVVFSYYGMFLWLPSVMVL-KGFSLVNSFGYVLIMTL 256
Cdd:cd17502 167 RT--------------------------------ILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLII 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 257 AQLPGYFFAAWLIEKWGR--KWVLGSFLIGTAISA--YFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIR 332
Cdd:cd17502 215 GLVIGSIISGALISKTGRykPLIVIGTILMSVGAGllTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADV 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 640586472 333 GSGSGLAAAVGRIGGIVGpflvgylinqkVSITVIFtiFTVAILMAAGAVLLFGVE 388
Cdd:cd17502 295 GVATATNTFFRSLGGTLG-----------VAITDVF--LVALALAALAFLLSLFLP 337
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
43-385 |
2.71e-08 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 55.35 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 43 QMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS---PSLIVFMALRLLVGIGLGGELPVASTL 119
Cdd:cd17357 50 LWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMY 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 120 ISENTPDATRGRAVVLLESFWAAGWLAASLLAY-FVIPNW-GWRVVLLITSLPAVYTLVLREHVKDS--------HEPAT 189
Cdd:cd17357 130 LQEISPSELRGALGSLTQIGVTLGILLGQVFGLpSVLGTEtLWPYLLFFPGIPALLQLAALPFFPESpkflliskGDEEE 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 190 IQKPLPFMQRVT-----------------------KLWQ----PAYRQKTALLWFVWFLVVFS------YYGMFLWLPSV 236
Cdd:cd17357 210 AEKSLKFLRGIEddvdqeleeikkeseqmgdqkqvSLMQllrdPSLRLPLLLVLVVSASQQFSginaifFYSTFIFENAG 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 237 MVLKGFSLVNSFGYVL--IMTLAqlpgyffAAWLIEKWGRKWVLGSFLIGTAISAYFFgtaqSVGLLIS----------A 304
Cdd:cd17357 290 FSPQLAEWANLGIGIVnvLSTIV-------GPFLIEKVGRRPLLLISLSVCAVALLLM----SVFLFLSeqnswmsygcI 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 305 GALLSF---FNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLvgYLINQKVSITVIFTIFtvAILMAAGA 381
Cdd:cd17357 359 VAIFLFiffFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMA--FPPLQSIGGGFVFIIF--AIPCALFL 434
|
....
gi 640586472 382 VLLF 385
Cdd:cd17357 435 LYLY 438
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
20-360 |
3.71e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.89 E-value: 3.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 20 AMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFM 99
Cdd:cd17503 9 ILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 100 ALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLre 179
Cdd:cd17503 89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 180 hvkdshepatiqkpLPFMQrvtkLWQPAYRQKTALLwFVWFLVVFSYYGMFLWLPSVM-VLKGFSLVNSfGYVLI-MTLA 257
Cdd:cd17503 167 --------------APLLD----LRLFKDRNFTLGL-LLSFLLGLGLFGAMFLLPLYLqNVLGYSAFES-GLVLApGGLA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 258 QLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFF-------GTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYpai 330
Cdd:cd17503 227 SAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLafltpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQ--- 303
|
330 340 350
....*....|....*....|....*....|
gi 640586472 331 iRGSGSGLAAAVGRIGGIVGPFLVGYLINQ 360
Cdd:cd17503 304 -IGDATALFNTIRQLGGSIGTALLATLLTN 332
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
33-383 |
4.70e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.55 E-value: 4.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 33 LAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGE 112
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 113 LPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPA-----VYTLVLREhvkdshEP 187
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSilaavLFWLFYRE------PP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 188 ATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGM-FLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAA 266
Cdd:cd17475 176 AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALlTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 267 WLIEKWG---RKWVL---GSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAA 340
Cdd:cd17475 256 RVSDRVFggrRRPVLvitAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLAN 335
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 640586472 341 AVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVL 383
Cdd:cd17475 336 TINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-385 |
5.97e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 5.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 215 LWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVL-IMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFG 293
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLtLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 294 TAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQkVSITVIFTIFTV 373
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILAI 159
|
170
....*....|..
gi 640586472 374 AILMAAGAVLLF 385
Cdd:pfam07690 160 LSLLAAVLLLLP 171
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
29-385 |
6.37e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.12 E-value: 6.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 29 VIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIG 108
Cdd:cd17323 21 ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 109 LGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLrehvkdshepa 188
Cdd:cd17323 101 GSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLIL----------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 189 tiqkPLPFMQRVtklwqpayrqktALLWFVWFLVVFSYYGMFLWLPSV-MVLKGFSLvnsfGYVLIMTLAQLPGYFFAAW 267
Cdd:cd17323 170 ----IFLFLPIV------------LLLGLYVGLVYAILYLFLTAFPYVfGEVYGFSP----GEVGLMYLPIGIGALIGSI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 268 L---IEKWGRKW------------------VLGSFLIGTAISAYFFGTAQSVGLL--ISAGALLSFFNLGAWGALYAYTP 324
Cdd:cd17323 230 IggrLSDYYYRRlkkknggkpepearlppaFIGAFLFPIGLFIFGWTIYPHIHWIvpIIGSAFFGFGLMLIFQSSLTYLV 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 325 EQYPaiiRGSGSGLAAA--VGRIGGIVGPFLVGYLINqKVSITVIFTIFT-VAILMAAGAVLLF 385
Cdd:cd17323 310 DSYP---KYAASALAANtlVRSIFAAIFPLFAQPMFN-NLGVGWAFTLLAfISLAMIPIPFIFY 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
24-385 |
9.35e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 9.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 24 GLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRN-----SLLFSLLLFSIGNGLSALSPSLIVF 98
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRllilaDLLRALLAAVLALLALLGSLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 99 MALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLR 178
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 179 EHVKDSHEPATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFlWLPSVMVLKGFSLVNSFGYVLIMT--- 255
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAL-TVLLPLLAKEVLGGGAAGYGLLLAafg 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 256 LAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSG 335
Cdd:cd06173 255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 640586472 336 SGLAAAVGRIGGIVGPFLVGYLInQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd06173 335 FSVYNALNSGAMPLGALLAGLLA-DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
38-386 |
3.66e-07 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 3.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 38 HLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGL-SALSPSLIVFMALRLLVGIGLGGELpvA 116
Cdd:cd17339 30 GLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLrSLGGIALLFLGTALAGAGIAVGNVL--L 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 117 STLISENTPDatrgRAVVLLESFWAAGWLAASLLAYFVIP-----NWGWRVVLLITSLPAVYTLV-----LREHVKDSHE 186
Cdd:cd17339 108 PSLIKRDFPR----RVGLMTGLYTTSMNLGAALASGLSVPlaqalGGGWRGALAIWALPALLALLiwlpqLRRRKRAAAA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 187 PATiqkplpfmQRVTKLWqpayrqKTALLWFVWF---LVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYF 263
Cdd:cd17339 184 AAP--------LTKISVW------RSPLAWQVTLfmgLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 264 FAAWLIEK----WGRKWVLGSFLIGTAISAYFFGTAQSV--GLLISAGALLSFFNLGAWGALYAYTPEQYPAIirgsgSG 337
Cdd:cd17339 250 LVPILATRlknqRPIVVLLAVLFIIGVLGLLFAPTALALlwAVLLGLGGGAAFSLALTLISLRSSDPAEAAAL-----SG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 640586472 338 LAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLFG 386
Cdd:cd17339 325 MAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGLGAG 373
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
56-360 |
4.99e-07 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 51.48 E-value: 4.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 56 AIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVL 135
Cdd:cd17361 65 LVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 136 LESFWAAGWLAASLLAYFV--IPNWGWRVVLLITSLPAVYTLVLREHVKDS--HEPATIQKPLPFMQRVTKLwqpayrqk 211
Cdd:cd17361 145 FQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLFLPETpnSPQLVIAILIPFFQQLTGI-------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 212 TALLWFVwflvvfsyygmflwlPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVL--------GSFLI 283
Cdd:cd17361 217 NVIMFYA---------------PVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLleggvqmlASQVA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 284 GTAISAYFFGTAQ--SVGLLISAGALLSFFNLG---AWGALYAYTP-EQYPAIIRGSGSGLAAAVGriggivgpFLVGYL 357
Cdd:cd17361 282 IGILLAVKFGDGGelPKAYAIAVVVLICLYVAAfawSWGPLGWLVPsEIFPLETRSAGQSLTVAVN--------FLFTFV 353
|
...
gi 640586472 358 INQ 360
Cdd:cd17361 354 IAQ 356
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
32-385 |
7.10e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.69 E-value: 7.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 32 ALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLI-VFMALRLLVGIGLG 110
Cdd:cd17353 28 PLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFLGYGVLGGIGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 111 GELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNwgwRVVLLITSLPAVYTLVL----------REH 180
Cdd:cd17353 108 IGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTV---GVPTTFLILGIIFLIIIvigaflirdpPKG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 181 VKDSHEPATIQKPLPFMQRVTklWQPAYRQKTA-LLWFVWFLVVFsyYGMFL---WLPSVMVLKGFSLVNSFGYVLIMTL 256
Cdd:cd17353 185 WVPPGVDPLANNAENSPRDYT--PREMLRTPTFwLLWLMFFLNAT--AGLMLigqAKPIGQEFAGLDAGIAALAVSILSI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 257 AQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALY-AYTPEQYPAIIRGSG 335
Cdd:cd17353 261 FNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFpALTADFFGTKNAGTN 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 640586472 336 SGLAAAVGRIGGIVGPFLVGYLINqkvSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17353 341 YGLLYTAKGVGGLIGPIIAAYVLY---TGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
36-386 |
3.64e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.45 E-value: 3.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 36 EWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPV 115
Cdd:cd06180 28 ELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 116 ASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYF-VIPNWGWRVVLLITSLPAVYTLVLREHVKDSHEPATIQKPL 194
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAgLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 195 PFMqrvtklwQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGR 274
Cdd:cd06180 188 AES-------APGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 275 KWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAiIRGSGSGLAAAVGRIGGIVGPFLV 354
Cdd:cd06180 261 RRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPP-AAPRALALMTASFGVGQILGPLLA 339
|
330 340 350
....*....|....*....|....*....|..
gi 640586472 355 GYLINQKVSITVIFTIFTVAILMAAGAVLLFG 386
Cdd:cd06180 340 GWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
45-168 |
6.20e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 47.99 E-value: 6.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 45 GLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIgLGGELPVASTLISENT 124
Cdd:PRK09874 57 GLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQV 135
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 640586472 125 PDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITS 168
Cdd:PRK09874 136 PRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITA 179
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
57-339 |
8.24e-06 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 47.35 E-value: 8.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 57 IGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPS--------LIVFMALRLLVGIGLGGELPVASTLISENTPDAT 128
Cdd:cd17366 55 LGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTyatigvwaPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 129 RGRAVVLLESFWAAGWLAASLLAYFV--------IPNWGWRVVLLITSLPAVYTLVLRehvkdshepatiqKPLpfmqrv 200
Cdd:cd17366 135 RGFLGSWLEFGTLAGFILGAGLVTLLtlllteaqMLDWGWRIPFLIAAPLGLVGLYLR-------------RPL------ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 201 tklwqpayrqktaLLWFVWFLVV-FSYYGMFLWLPSVM-VLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVL 278
Cdd:cd17366 196 -------------LICIGLVLVFnVTNYMLLSYMPSYLeETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVY 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640586472 279 GSFLIGT---AISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLA 339
Cdd:cd17366 263 AAGLAGLlvlAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIA 326
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
7-177 |
9.68e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.20 E-value: 9.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 7 KLLWAAGGAWLFDAMDVGLLSFVIAALAKEwhLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGN 86
Cdd:cd17489 194 KKVLPPALILFLASIAYGAISTFLPLYAAE--RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 87 GLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLI 166
Cdd:cd17489 272 LLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLL 351
|
170
....*....|.
gi 640586472 167 TSLPAVYTLVL 177
Cdd:cd17489 352 AAVVVLLALVL 362
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-380 |
1.35e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.99 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 20 AMDVGLLSFviAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFM 99
Cdd:TIGR00710 20 GIDMYLPAF--PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 100 ALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLRE 179
Cdd:TIGR00710 98 VLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 180 HVKdshepATIQKPLPFMQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWL---PSVMVLKGFSLVNSFGYVLIM-T 255
Cdd:TIGR00710 178 FIL-----PETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFsgaPFVYIDIMGVSPSVFGLLFALnI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 256 LAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLG-AWGALYAYTP----EQYPAI 330
Cdd:TIGR00710 253 IAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGiGNSMISSIAMayalEDFPHV 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 640586472 331 IRGSGSGLAAAVGRIGGIVGPFLVgyLINQKVSITVIFTIFTVAILMAAG 380
Cdd:TIGR00710 333 AGTASALFGTLRLVLGAIVGYLVS--LIHGNTAWPMSLSCLVLAVVSVLA 380
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
11-177 |
1.59e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.85 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 11 AAGGAWLFDAMDVGLLSFVIAALAKEWHlNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSA 90
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 91 LSPSLIVFMALRLLVGIGLGGELPVAStLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNW--GWRVVLLITS 168
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGAA-VASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINA 159
|
....*....
gi 640586472 169 LPAVYTLVL 177
Cdd:cd06179 160 IFNALALIL 168
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
27-347 |
4.23e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 45.37 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 27 SFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS-PSLIVFMALRLLV 105
Cdd:TIGR00886 22 PLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 106 GIGlGGELPVASTLISENTPDATRGRAVVLlesfwAAGW-LAASLLAYFVIP----------------NWGWRVVLLITS 168
Cdd:TIGR00886 102 GIA-GGSFASCMPWISFFFPKKIQGTALGL-----AAGWgNMGGGVAQFVMPpiigslifgggqpahlAWGWAFVIVPAG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 169 LPAVYTLVLREHVKDShePATIQKPLPFMQRvtklwQPAYRQKTALLWFVWFLVVFSYyGMFLWLPSV--MVLK---GFS 243
Cdd:TIGR00886 176 ILLLPALLIFFVGADT--PPGKPATGKLSFK-----EALKVFGNRHTWILALLYSVTF-GSFLGVSSIfaMLFKdqfGLS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 244 LVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAY----FFGTAQSVGLLISAGALLSFFNLGAWGAL 319
Cdd:TIGR00886 248 KVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFlvvlGLVSDGSLAAFIVLFVALFFFAGAGNGST 327
|
330 340
....*....|....*....|....*...
gi 640586472 320 YAYTPEQYPAIIrGSGSGLAAAVGRIGG 347
Cdd:TIGR00886 328 FALVPHIFRRAT-GAVSGLIGAIGNLGG 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
7-177 |
4.98e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 7 KLLWAAGGAWLFDAMdvGLLSFVIAAL-AKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIG 85
Cdd:cd17370 200 KAFWLYLLAVALFAL--GNFSFAFLILrAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 86 NGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLL 165
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
|
170
....*....|..
gi 640586472 166 ITSLPAVYTLVL 177
Cdd:cd17370 358 FSAVLALIALLL 369
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
19-169 |
1.47e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 43.37 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 19 DAMDVGLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVF 98
Cdd:cd17390 8 DLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALL 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640586472 99 MALRLLVGIgLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLL-AYFVIPNWGWRVVLLITSL 169
Cdd:cd17390 88 FLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVgGHLAETDGGFYYVALLCSA 158
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
33-387 |
3.24e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.54 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 33 LAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFM-ALRLLVGIGLGG 111
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYlTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 112 ELPVASTLISeNTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITslpavytlvlrehvkdshepATIQ 191
Cdd:cd17352 109 IYSPAIVIVG-QYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLIL--------------------GGLC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 192 KPLPFMQRVTKLWqpayRQKTALLWFVWFLV-VFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIE 270
Cdd:cd17352 168 LNLCVCGLLLRLL----KDPTFVLLALGVSFaMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 271 KW--GRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNlgawGALYAYTPEQYPAIIR----GSGSGLAAAVGR 344
Cdd:cd17352 244 KPriGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCS----GSYSSLTPVILADLVGleklSNAYGLVLLFQG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 640586472 345 IGGIVGPFLVGYLINQKVSITVifTIFTVAILMAAGAVLLFGV 387
Cdd:cd17352 320 LAALVGPPIAGLLRDYTGDYDA--AFYFCGACLLLSGVLLFLL 360
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
46-387 |
3.66e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 46 LIGSVGSIGMAIGAV---FFGALADKIGRRNSLLFSLLLFSIGN--GLSALSPSLIVFMALRLLVG-IGLGGELPVASTL 119
Cdd:COG2270 53 LWGYALAIAGLLVALlapVLGAIADRSGRKKPFLAFFTLLGVLAtaALFFVAPGGLWLGLLLFVLAnIGFEGSLVFYNAF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 120 ISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGW----------RVVLLITSLP-AVYTLVLREHVKDSHEPA 188
Cdd:COG2270 133 LPDIATPEEIGRVSGLGWALGYLGGVLLLLINLALFLKPEAfglpdageavRISFLLTALWwLLFALPLFLFLPERPRPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 189 TIQKPLPFMQRVTKLWQ-----PAYRQktallwFVWFLVVFsyygMFLW--LPSVMVLKGFSLVNSFG--------YVLI 253
Cdd:COG2270 213 PAPPRGAVRAGFRELRRtlrelRRYRD------LLRFLLAY----FFYRdgVQTVIAFAGIYAAGVLGfsttelivFGLL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 254 MTLAQLPGYFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRG 333
Cdd:COG2270 283 VQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREA 362
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 640586472 334 SGSGLAAAVGRIGGIVGPFLVGYLI----NQKVSITVIftiftvAILMAAGAVLLFGV 387
Cdd:COG2270 363 EFFGLYALSGKAASFLGPLLFGLVTqltgSQRLGILSL------IVFFVIGLVLLLRV 414
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
57-339 |
5.00e-04 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 41.85 E-value: 5.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 57 IGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPS---------LIVFMAlRLLVGIGLGGELPVASTLISENTPDA 127
Cdd:PRK15075 71 LGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIAFVPGyatiglaapLLVLLG-RLLQGFSAGVELGGVSVYLAEIATPG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 128 TRG-----------RAVVllesFWAA-GWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLREHVKDSHEpatiqkplp 195
Cdd:PRK15075 150 RKGfytswqsasqqVAVV----FAALlGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEE--------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 196 FMQRVTKlwqPAYRQKTALLWFVWFLVVfsyYGMFLwlpSVMVLKGFSLVN----SFGYV---------LIMTLAQLPGY 262
Cdd:PRK15075 217 FLARKHR---PSMREIFRSLAANWRIVL---AGMLM---VAMTTVSFYLITvytpTFGKTvlhlsaadsLLVTLCVGVSN 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 263 FFaaWL------IEKWGRKWVLGSFLIGTAISAY----FFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIR 332
Cdd:PRK15075 288 FI--WLpiggalSDRIGRRPVLIAFTVLAILTAYpalsWLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVR 365
|
....*..
gi 640586472 333 GSGSGLA 339
Cdd:PRK15075 366 TAGFSLA 372
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
7-339 |
5.10e-04 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 42.01 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 7 KLLWAAGGAWLFDAM---DVGLLSFVIAALAKEWHLNSG---QMglIGSVGSIGMA-----IGAVFFGALADKIGRRNSL 75
Cdd:PRK10642 13 KLRKAITAASLGNAMewfDFGVYGFVAYALGKVFFPGADpsvQM--IAALATFSVPflirpLGGLFFGMLGDKYGRQKIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 76 LFSLLLFSIGNGLSALSPSL--------IVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVVLLESFWAAGW--- 144
Cdd:PRK10642 91 AITIVIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFvlg 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 145 -----LAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLR----------EHV----KDSHEPATIQKPLPFMQRVTKLWQ 205
Cdd:PRK10642 171 agvvvLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRhaleetpafqQHVdkleQGDREGLQDGPKVSFKEIATKHWR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 206 payrqktALLWFVWFLVV--FSYYGMFLWLPSVmvlkgfsLVNSFGY-----VLIMtLAQLPGYFFA----AWLIEKWGR 274
Cdd:PRK10642 251 -------SLLTCIGLVIAtnVTYYMLLTYMPSY-------LSHNLHYsedhgVLII-IAIMIGMLFVqpvmGLLSDRFGR 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640586472 275 K--WVLGSF-LIGTAISAYFFGTAQSVGlLISAGALLSFFNLGAWGALYAYT-PEQYPAIIRGSGSGLA 339
Cdd:PRK10642 316 RpfVILGSVaLFVLAIPAFILINSNVIG-LIFAGLLMLAVILNCFTGVMASTlPAMFPTHIRYSALAAA 383
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
29-322 |
6.81e-04 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 41.45 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 29 VIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIG 108
Cdd:PRK03699 29 VMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMFVLGVV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 109 LGGELPVASTLISENTPDATRGRAVVLLESFW-AAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVL---------R 178
Cdd:PRK03699 109 SGITMSIGTFLITHVYEGKQRGSRLLFTDSFFsMAGMIFPIIAAYLLARSIEWYWVYACIGLVYVAIFILtlfsefpalG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 179 EHVKDSHEPATIQKplpfmqrvtklWQPAyrqkTALLWFVWFLVVFSYYGMFLWLPSVMVLK-GFSLVNSFGYVLIMTLA 257
Cdd:PRK03699 189 KHAPKADKPVAKEK-----------WGIG----VLFLAIAALLYILAQLTFISWVPEYAQKKfGMSLEDAGNLVSNFWMA 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640586472 258 QLPGYFFAAWLIEKWG-RKWVLGSFLIGTAISAYFFGTAQSVGLLISAGAlLSFFNLGAWGALYAY 322
Cdd:PRK03699 254 YMVGMWIFSFIVRFFDlQRILTVLAGLALVLMYLFVNTDDPSHLLYAILG-LGFFSSAIYTTIITL 318
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
15-385 |
9.21e-04 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 41.18 E-value: 9.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 15 AWLFDAMDVGLLSFVIAALAKEWHLN-SGQMGLIGSVGsIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSP 93
Cdd:cd17396 8 NYFVHGMGVIILAQNMSSLSEKWHTDvAGVAYVISGIG-IGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 94 SLIVFMALRLLVGIGlggelpvASTLISENTPDATR------GRAVVLLESFWAAGWLAASLLAYFVIPN-----WGWRV 162
Cdd:cd17396 87 NLIIAYVFALLAGAA-------NSFLDTGTYPALMEafpkasGSANILVKAFVSFGQFLLPFIIAFLAANnlwygWSFIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 163 VLLITSLPAVYTLVLREHVKDSHEPATIQKPLPFMQRvtklwQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSV-MVLKG 241
Cdd:cd17396 160 PAAVLVLNALLLLKLSFPPQTVTAANTKQKEIPVKRE-----KPKFLIEGIALILIGFTSTATFYLFSQWMPKYgSAVAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 242 FSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRK-WVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALY 320
Cdd:cd17396 235 MGEAESLKLISYYSMGSLVCVFITAVLLKRYVRPiWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640586472 321 AYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQkVSITVIFTI-FTVAILMAAGAVLLF 385
Cdd:cd17396 315 LTLMAEFFPKGKGKVTGIYMIASSLANFVIPLITGIIASA-IGIAYIFLFdFGIALLGLLLAIFVF 379
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
30-357 |
1.66e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 30 IAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGL 109
Cdd:cd17393 22 IPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAAN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 110 GGeLPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFVI-------PNWGWRVVLLITSLPAVYTLVLREHVK 182
Cdd:cd17393 102 GA-LDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIgagvspgVHLLAAAVLLLLAALVAIRALLPGTGE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 183 DSHEPATIQKPLPFMQRVTKLWqpayrqktaLLWFVWFLVVFSYYGMFLWLPSVMV-LKGFSL-VNSFGYVLiMTLAQLP 260
Cdd:cd17393 181 AAEDRPDGAGKPGFLLPNRLLL---------LLGLLALAAALAEGAAADWSALYLRdVLGASAaLAALGYAV-FSLAMTV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 261 GYFFAAWLIEKWGRKWVLgsfLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWG---ALYAYTPEQyPAIIRGSGSG 337
Cdd:cd17393 251 GRLFGDRLVDRFGDVAVL---RAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVvvpLAFSAAGAL-PGLAAGIAVA 326
|
330 340
....*....|....*....|
gi 640586472 338 LAAAVGRIGGIVGPFLVGYL 357
Cdd:cd17393 327 RVATLGYLGFLVGPPLIGFL 346
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
46-385 |
1.68e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 46 LIGSVGSIGMAIGAVFF---------GALADKIGRRNSLLFS-LLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPV 115
Cdd:cd17490 26 LGASLSMIGIILGAYGIsqmllriplGILSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 116 ASTLISENTPDATrGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLPAVYTLVLREHVKDSHEPATIQKPLp 195
Cdd:cd17490 106 TVLYASYFPPDEA-AKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTE- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 196 fMQRVTKLWqpayrqKTALLWFVWFLVVFSYY----GMFLWLPSVMVLKGFSlvnSFGYVLIMTLAQLPG----YFFAAW 267
Cdd:cd17490 184 -LKELLSVL------KDKKLLFFSLLAILQQMitfsTTFGFTPLIAKQLGAS---SFQLGLLSIIYLLPNalasLLSGTL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 268 LIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFfnlgAWGALYAYTP----EQYPAIIRGSGSGLAAAVG 343
Cdd:cd17490 254 FYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGF----GTGILFPLLMslsiEGVPAEQRSTAMGFFQAIY 329
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 640586472 344 RIGGIVGPFLVGYlINQKVSITVIFtiFTVAILMAAGAVLLF 385
Cdd:cd17490 330 ALGMFLGPVLVGI-ISEAFGLQTGF--FVIGVIALLAAILSL 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
197-358 |
1.74e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.79 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 197 MQRVTKLWQPAYRQKTALLWFVWFLVVFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKWGRKW 276
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 277 VLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGY 356
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
..
gi 640586472 357 LI 358
Cdd:COG0477 161 LV 162
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
34-386 |
2.34e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.70 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 34 AKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSP-SLIVFMALRLLVGIGLGGE 112
Cdd:cd17314 30 QDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFnSFPLSYACFVFIGAGTGIL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 113 LPVASTLISENTPDaTRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITSLpAVYTLVLREHVKDSHEPATIQK 192
Cdd:cd17314 110 YGSAVLVTTQYFPD-TKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGI-LAAIVLSVVSLLGFKEPPDNQA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 193 PLPFMQRVTKLWQPAYRQK-TALLWFVWFLVVFSYYGMFLWLPSVMV-LKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIE 270
Cdd:cd17314 188 RLHVQKKKTQTMGEIFRDKvFWILFIAIFLVLIGGFLFIANMASLVRsLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVAD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 271 KWGRKWVLGS---FLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAWGALYAYTPEQYPAIIRGSGSGLAAAVGRIGG 347
Cdd:cd17314 268 FFGGRLSTLSillTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGS 347
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 640586472 348 IVGPFLVG--YLINQKVSITVIFTIFTVAIlmaAGAVLLFG 386
Cdd:cd17314 348 ILGPMLGAkfYDRTPSYISAVYIYAVIVFL---ASAILLAV 385
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
24-177 |
3.18e-03 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 39.68 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 24 GLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIgNGLSALSPS--------- 94
Cdd:PRK10077 37 SLNTVFVAPQNLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFI-SALGSAWPEfgftsigpd 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 95 ----LIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRAVvlleSFWAAGWLAASLLAYFVipNW------------ 158
Cdd:PRK10077 116 ntgyVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLV----SFNQFAIIFGQLVVYFV--NYfiarsgdaswln 189
|
170 180
....*....|....*....|.
gi 640586472 159 --GWRVVLLITSLPAVYTLVL 177
Cdd:PRK10077 190 tdGWRYMFASEAIPALLFLML 210
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
53-172 |
3.58e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 39.40 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 53 IGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENTPDATRGRA 132
Cdd:cd17435 47 IGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLL 126
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 640586472 133 VVLLESFWAAGWLAASLLAY-FVIPNWGWRVVLLITSLPAV 172
Cdd:cd17435 127 VSLNELMIVIGILLAYISNYaFANVSNGWKYMFGLVIPLAA 167
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
33-307 |
4.87e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 38.76 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 33 LAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSP----SLIVFMALRLLVGIG 108
Cdd:cd17345 29 LIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsatsSVGLMFILLFLNGWF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 109 LGGELPVASTLISENTPDATRGRAVvlleSFW---------AAGWLAASLLAYFVIPNWGWR-----VVLLITSLPAVYT 174
Cdd:cd17345 109 QGMGWPPSGRTMVHWFSKKERGTWT----SIWnishnvgggLVGPLAGLGLAIFGDGWWRGAfifpaIIAIIVAVIVLFL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 175 L-------------VLREHVKDSHEPATIQKPLPFMQRVTKlwqpaYRQKTALLWFVWFLVVFSY---YGMFLWLPSVMV 238
Cdd:cd17345 185 GkdtpeseglppieEYKGDYPEEADGEEEEQELSAWEIFVK-----YVLKNKLLWYIAIANVFVYlvrYGILDWAPTYLS 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640586472 239 -LKGFSLVNSFGYVLIMTLAQLPGYFFAAWLIEKW--GRKW---VLGSFLIGTAISAYFFGTAQSVgLLISAGAL 307
Cdd:cd17345 260 eVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRAptgIIFMILVIVALIVYWLAPNVLV-DLIALIAL 333
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
17-384 |
5.06e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.77 E-value: 5.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 17 LFDAMDVGLLSFVIAALAKE--WHLNSG--QMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALS 92
Cdd:cd17388 9 LLDAMGIGLIMPVLPTLLREfvGDSADAatHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 93 PSLIVFMALRLLVGIgLGGELPVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYFV------IPNWgwrVVLLI 166
Cdd:cd17388 89 PTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLgeisprAPFL---VAAGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 167 TSLPAVYTL-VLREHVKDSHEPATIQKPL-PFMQRVTKLWQPAYRQKTALLWFVWFL-----VVFSYYGM--FLWLPsVM 237
Cdd:cd17388 165 NGLNFLLGLfVLPESLPPERRRAFRWRRAnPFGSLRWLTGFPGLLGLLAVFFLIQLIgqvpaTTWVLFTEdrFDWSP-TM 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 238 VlkGFSLVnsfGYVLIMTLAQLpgyFFAAWLIEKWGRKWVLGSFLIGTAISAYFFGTAQSVGLLISAGALLSFFNLGAwG 317
Cdd:cd17388 244 V--GLSLA---VFGLLHALFQA---FVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAG-P 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 640586472 318 ALYAYTPEQYPAIIRGSGSGLAAAVGRIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLL 384
Cdd:cd17388 315 ALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIIGAALYLICLVLA 381
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
24-111 |
5.74e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.60 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 24 GLLSFVIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRL 103
Cdd:COG2270 256 TVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGL 335
|
....*...
gi 640586472 104 LVGIGLGG 111
Cdd:COG2270 336 LIGLVMGG 343
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
29-276 |
6.77e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.35 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 29 VIAALAKEWHLNSGQMGLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIG 108
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 109 LGgelpVASTLISENTPDATRGRAVVLLESFWAAGWLAASLLAYF----VIPNWGWRVV-LLITSLPAVYTLVLREHVKD 183
Cdd:PRK11652 110 TG----VGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLigglLTTLFGWRACyLFLLLLGAGVTFSMARWMPE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 184 ShepatiqkpLPFMQRVTKLWQpAYRQKTALLWFVWFLV--VFSYYGMFLWLPSVMVLKGFSLVNSFGYVLIMTLAQLPG 261
Cdd:PRK11652 186 T---------RPADARRTRVLA-SYRTLLSNRRFNCYLLmlIGTLAGIAVFEACSGVLMGAVLGLSSMTVSILFILPIPA 255
|
250
....*....|....*
gi 640586472 262 YFFAAWLIEKWGRKW 276
Cdd:PRK11652 256 AFFGAWFAGRPNKRF 270
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
214-385 |
7.51e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.37 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 214 LLWF-----VWFLVV------FSYYGMFLWLPSVM--VLkGFS-----LVNSFGYVLIMTLAQLPGYFfAAWLIEKWG-- 273
Cdd:cd17318 192 LLWFflvlpVWAIVVahfghnWGFYTLLTELPTYMsdVL-HFNiksngFLSSLPYLAMWICSIVGGYL-ADWLRSRGIls 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 274 ----RK-------WVLGSFLIGTAISAYFFGTAqsVGLLISAGALLSFFNLGAWGALYAYTPeQYPAIIRGSGSGLAAav 342
Cdd:cd17318 270 tttvRKlftsigfLGPGVFLIALGYLGSNATLA--VVFLTLSVGLSGACYSGFLVNHLDLAP-NYAGTLMGITNTAAT-- 344
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 640586472 343 grIGGIVGPFLVGYLINQKVSITVIFTIFTVAILMAAGAVLLF 385
Cdd:cd17318 345 --IAGIISPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIFY 385
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
45-168 |
7.89e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.36 E-value: 7.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 45 GLIGSVGSIGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGGELPVASTLISENT 124
Cdd:PRK09874 261 GMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNS 340
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 640586472 125 PDATRGRAVVLLESFWAAGWLAASLLAYFVIPNWGWRVVLLITS 168
Cdd:PRK09874 341 SNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTA 384
|
|
| MFS_SLC22A17 |
cd17445 |
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ... |
53-111 |
8.21e-03 |
|
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341003 [Multi-domain] Cd Length: 346 Bit Score: 37.83 E-value: 8.21e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 640586472 53 IGMAIGAVFFGALADKIGRRNSLLFSLLLFSIGNGLSALSPSLIVFMALRLLVGIGLGG 111
Cdd:cd17445 47 LGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAG 105
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
250-363 |
9.02e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 38.00 E-value: 9.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640586472 250 YVLIMTLAQLPGYFFAAWLIEKWGRKWVLG----SFLIGTAISAyffgTAQSVGLLISAGALLSFFNLGAWGALYAYTPE 325
Cdd:cd17361 56 FTSSLYLAGLVASLLASYVTRKWGRKPSMLiggvLFLVGAALNA----AAQNIAMLIVGRILLGFGVGFGNQAVPLYLSE 131
|
90 100 110
....*....|....*....|....*....|....*...
gi 640586472 326 QYPAIIRGSGSGLAAAVGRIGgivgpFLVGYLINQKVS 363
Cdd:cd17361 132 MAPAKLRGALNIGFQLAITIG-----ILIANLINYGTS 164
|
|
| |
