NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|639685982|ref|WP_024718963|]
View 

MULTISPECIES: proline dehydrogenase family protein [Bacillus]

Protein Classification

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; proline dehydrogenase family protein; proline dehydrogenase family protein( domain architecture ID 11423475)

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase catalyzes the two-step oxidation of proline to glutamate; bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase catalyzes the two-step oxidation of proline to glutamate; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PutA super family cl33919
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 32-290 7.86e-82

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


The actual alignment was detected with superfamily member COG0506:

Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 266.14  E-value: 7.86e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  32 KKIIGGKDFESAIPVIKRLNDQGMAVTVDHLGEFVTKAEIANERTNECIQTIQRIAEAGL-NSHVSLKMTSLGLDIDD-- 108
Cdd:COG0506  114 RRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVdRPGVSVKLSALGPRYSPaq 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 109 -----DLVYRNMKSILDTAEKHRIMVTIDMEDEQRCQKTLDIFKEMKSQ-----YEYVSTVLQAYLYRTEQDLDDLNEL- 177
Cdd:COG0506  194 rervvEELLERLRPLARAAREAGIFVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYLKRAEADLDRLAALa 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 178 -----QPFLRLVKGAYKESAEV----------AYPNKKDVDQNYKKLIEKQLLSGN--YTAIATHDDQMIEFTKHIVKKH 240
Cdd:COG0506  274 rrggrRIRVRLVKGAYWDPEIVraqvhgwpypVFTRKADTDANYLRCARKLLEAGDaiYPQFATHNARTIAAALALAGER 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 639685982 241 NIQTSQFEFQMLYGMRSETQQALVKE-GYQMRVYTPYG-----REWYGYYMRRLAE 290
Cdd:COG0506  354 GRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVVapvggDAALAYLLRRLLE 409
 
Name Accession Description Interval E-value
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 32-290 7.86e-82

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 266.14  E-value: 7.86e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  32 KKIIGGKDFESAIPVIKRLNDQGMAVTVDHLGEFVTKAEIANERTNECIQTIQRIAEAGL-NSHVSLKMTSLGLDIDD-- 108
Cdd:COG0506  114 RRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVdRPGVSVKLSALGPRYSPaq 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 109 -----DLVYRNMKSILDTAEKHRIMVTIDMEDEQRCQKTLDIFKEMKSQ-----YEYVSTVLQAYLYRTEQDLDDLNEL- 177
Cdd:COG0506  194 rervvEELLERLRPLARAAREAGIFVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYLKRAEADLDRLAALa 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 178 -----QPFLRLVKGAYKESAEV----------AYPNKKDVDQNYKKLIEKQLLSGN--YTAIATHDDQMIEFTKHIVKKH 240
Cdd:COG0506  274 rrggrRIRVRLVKGAYWDPEIVraqvhgwpypVFTRKADTDANYLRCARKLLEAGDaiYPQFATHNARTIAAALALAGER 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 639685982 241 NIQTSQFEFQMLYGMRSETQQALVKE-GYQMRVYTPYG-----REWYGYYMRRLAE 290
Cdd:COG0506  354 GRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVVapvggDAALAYLLRRLLE 409
Pro_dh pfam01619
Proline dehydrogenase;
43-294 1.87e-46

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 158.42  E-value: 1.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982   43 AIPVIKRLNDQGMAVTVDHLGEFVTKAEIANERTNECIQTIQRIAEA------GLNSHVSLKMTSLGLDIDD-------D 109
Cdd:pfam01619   1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAagpwplGPRPGISVKLSALHPRYEPlerervmA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  110 LVYRNMKSILDTAEKHRIMVTIDMEDEQRCQKTLDIFKEMKS-----QYEYVSTVLQAYLYRTEQDLDDLNEL-----QP 179
Cdd:pfam01619  81 ELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLLAepelrGWNGVGITLQAYLKDALAVLDWLLELarrrgRP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  180 F-LRLVKGAYKES----AEVA------YPNKKDVDQNYKKLIEKqLLSGN---YTAIATHDDQMIEFTKHIVKKHNIQTS 245
Cdd:pfam01619 161 LgVRLVKGAYWDSeikrAQQGgwpypvFTRKEATDANYEACARF-LLENHdriYPQFATHNARSVAAALALAEELGIPPR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 639685982  246 QFEFQMLYGMrSETQ-QALVKEGYQMRVYTPYG--REWYGYYMRRLAERPAN 294
Cdd:pfam01619 240 RFEFQQLYGM-GDNLsFALVAAGYRVRKYAPVGphEELLAYLVRRLLENTAN 290
PRK11904 PRK11904
bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;
122-297 1.68e-10

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;


Pssm-ID: 237017 [Multi-domain]  Cd Length: 1038  Bit Score: 61.75  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  122 AEKHRIMVTIDMEDEQRCQKTLDIFK-----EMKSQYEYVSTVLQAYLYRTEQDLDDLNELQ-------PfLRLVKGAYK 189
Cdd:PRK11904  281 AKEANIGLTIDAEEADRLELSLDLFEalfrdPSLKGWGGFGLAVQAYQKRALPVLDWLADLArrqgrriP-VRLVKGAYW 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  190 ES----AEVA----YP---NKKDVDQNY----KKLIEKQllsGN-YTAIATHDDQMIEFTKHIVKKHNiqtsqFEFQMLY 253
Cdd:PRK11904  360 DSeikrAQELglpgYPvftRKAATDVSYlacaRKLLSAR---GAiYPQFATHNAHTVAAILEMAGHRG-----FEFQRLH 431

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 639685982  254 GMRSETQQALVkEGYQM--RVYTPYG--REWYGYYMRRLAERPANIAF 297
Cdd:PRK11904  432 GMGEALYDALL-DAPGIpcRIYAPVGshKDLLPYLVRRLLENGANSSF 478
 
Name Accession Description Interval E-value
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 32-290 7.86e-82

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 266.14  E-value: 7.86e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  32 KKIIGGKDFESAIPVIKRLNDQGMAVTVDHLGEFVTKAEIANERTNECIQTIQRIAEAGL-NSHVSLKMTSLGLDIDD-- 108
Cdd:COG0506  114 RRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVdRPGVSVKLSALGPRYSPaq 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 109 -----DLVYRNMKSILDTAEKHRIMVTIDMEDEQRCQKTLDIFKEMKSQ-----YEYVSTVLQAYLYRTEQDLDDLNEL- 177
Cdd:COG0506  194 rervvEELLERLRPLARAAREAGIFVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYLKRAEADLDRLAALa 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 178 -----QPFLRLVKGAYKESAEV----------AYPNKKDVDQNYKKLIEKQLLSGN--YTAIATHDDQMIEFTKHIVKKH 240
Cdd:COG0506  274 rrggrRIRVRLVKGAYWDPEIVraqvhgwpypVFTRKADTDANYLRCARKLLEAGDaiYPQFATHNARTIAAALALAGER 353

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 639685982 241 NIQTSQFEFQMLYGMRSETQQALVKE-GYQMRVYTPYG-----REWYGYYMRRLAE 290
Cdd:COG0506  354 GRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVVapvggDAALAYLLRRLLE 409
Pro_dh pfam01619
Proline dehydrogenase;
43-294 1.87e-46

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 158.42  E-value: 1.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982   43 AIPVIKRLNDQGMAVTVDHLGEFVTKAEIANERTNECIQTIQRIAEA------GLNSHVSLKMTSLGLDIDD-------D 109
Cdd:pfam01619   1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAagpwplGPRPGISVKLSALHPRYEPlerervmA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  110 LVYRNMKSILDTAEKHRIMVTIDMEDEQRCQKTLDIFKEMKS-----QYEYVSTVLQAYLYRTEQDLDDLNEL-----QP 179
Cdd:pfam01619  81 ELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLLAepelrGWNGVGITLQAYLKDALAVLDWLLELarrrgRP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  180 F-LRLVKGAYKES----AEVA------YPNKKDVDQNYKKLIEKqLLSGN---YTAIATHDDQMIEFTKHIVKKHNIQTS 245
Cdd:pfam01619 161 LgVRLVKGAYWDSeikrAQQGgwpypvFTRKEATDANYEACARF-LLENHdriYPQFATHNARSVAAALALAEELGIPPR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 639685982  246 QFEFQMLYGMrSETQ-QALVKEGYQMRVYTPYG--REWYGYYMRRLAERPAN 294
Cdd:pfam01619 240 RFEFQQLYGM-GDNLsFALVAAGYRVRKYAPVGphEELLAYLVRRLLENTAN 290
PRK11904 PRK11904
bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;
122-297 1.68e-10

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;


Pssm-ID: 237017 [Multi-domain]  Cd Length: 1038  Bit Score: 61.75  E-value: 1.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  122 AEKHRIMVTIDMEDEQRCQKTLDIFK-----EMKSQYEYVSTVLQAYLYRTEQDLDDLNELQ-------PfLRLVKGAYK 189
Cdd:PRK11904  281 AKEANIGLTIDAEEADRLELSLDLFEalfrdPSLKGWGGFGLAVQAYQKRALPVLDWLADLArrqgrriP-VRLVKGAYW 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  190 ES----AEVA----YP---NKKDVDQNY----KKLIEKQllsGN-YTAIATHDDQMIEFTKHIVKKHNiqtsqFEFQMLY 253
Cdd:PRK11904  360 DSeikrAQELglpgYPvftRKAATDVSYlacaRKLLSAR---GAiYPQFATHNAHTVAAILEMAGHRG-----FEFQRLH 431

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 639685982  254 GMRSETQQALVkEGYQM--RVYTPYG--REWYGYYMRRLAERPANIAF 297
Cdd:PRK11904  432 GMGEALYDALL-DAPGIpcRIYAPVGshKDLLPYLVRRLLENGANSSF 478
PRK11905 PRK11905
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed
 122-297 1.15e-07

bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 237018 [Multi-domain]  Cd Length: 1208  Bit Score: 52.95  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  122 AEKHRIMVTIDMEDEQRCQKTLDIFKEMKSQ-----YEYVSTVLQAYLYRTEQDLDDLNEL------QPFLRLVKGAYKE 190
Cdd:PRK11905  280 AKAYDIGLNIDAEEADRLELSLDLLEALCSDpdlagWNGIGFVVQAYQKRCPFVIDYLIDLarrsgrRLMVRLVKGAYWD 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  191 S----AEVA----YP---NKKDVDQNY----KKLIEKQllsgnyTAI----ATHddqmieftkhivkkhNIQT------- 244
Cdd:PRK11905  360 AeikrAQVDglegFPvftRKVHTDVSYiacaRKLLAAR------DVIypqfATH---------------NAQTlaaiyel 418

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639685982  245 ----SQFEFQMLYGMrSETQQALV----KEGYQMRVYTPYG--REWYGYYMRRLAERPANIAF 297
Cdd:PRK11905  419 aggkGDFEFQCLHGM-GEPLYDQVvgkeKLGRPCRIYAPVGthETLLAYLVRRLLENGANSSF 480
PLN02681 PLN02681
proline dehydrogenase
 161-291 4.04e-06

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 47.77  E-value: 4.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982 161 QAYLYRTEQDL-DDLNELQPF-----LRLVKGAY----KESAEVA------YPNKKDVDQNYKK----LIEKQLLSGNYT 220
Cdd:PLN02681 274 QAYLKDARERLrLDLERSEREgvplgAKLVRGAYlsleRRLAASLgvpspvHDTIQDTHACYNRcaefLLEKASNGDGEV 353

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639685982 221 AIATHDDQMIEFTKHIVKKHNI--QTSQFEFQMLYGMRSETQQALVKEGYQMRVYTPYGR--EWYGYYMRRLAER 291
Cdd:PLN02681 354 MLATHNVESGELAAAKMNELGLhkGDPRVQFAQLLGMSDNLSFGLGNAGFRVSKYLPYGPveEVIPYLLRRAEEN 428
putA PRK11809
trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate ...
 112-297 2.86e-05

trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 236989 [Multi-domain]  Cd Length: 1318  Bit Score: 45.73  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  112 YRNMKSILDTAEKHRIMVTIDMEDEQRCQKTLDIFKEMKSQYEY-----VSTVLQAYLYRTEQDLDDLNEL------QPF 180
Cdd:PRK11809  350 YPRLKSLTLLARQYDIGINIDAEEADRLEISLDLLEKLCFEPELagwngIGFVIQAYQKRCPFVIDYLIDLarrsrrRLM 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685982  181 LRLVKGAYKES----AEV----AYP---NKKDVDQNYKKLIEKQLLSGN--YTAIATHDDQMIEFTKHIVKkHNIQTSQF 247
Cdd:PRK11809  430 IRLVKGAYWDSeikrAQVdgleGYPvytRKVYTDVSYLACARKLLAVPNliYPQFATHNAHTLAAIYHLAG-QNYYPGQY 508

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 639685982  248 EFQMLYGMRSETQQALV------KEGYQMRVYTPYG--REWYGYYMRRLAERPANIAF 297
Cdd:PRK11809  509 EFQCLHGMGEPLYEQVVgkvadgKLNRPCRIYAPVGthETLLAYLVRRLLENGANTSF 566
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH