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Conserved domains on  [gi|585363959|ref|WP_024245547|]
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terminase small subunit [Escherichia coli]

Protein Classification

terminase small subunit( domain architecture ID 10538622)

terminase small subunit binds to the packaging signal on DNA, allowing the terminase large subunit to cleave phage DNA and thread it through the portal protein channel into the procapsid, powered by ATP hydrolysis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Phage_Nu1 pfam07471
Phage DNA packaging protein Nu1; Terminase, the DNA packaging enzyme of bacteriophage lambda, ...
1-160 2.91e-78

Phage DNA packaging protein Nu1; Terminase, the DNA packaging enzyme of bacteriophage lambda, is a heteromultimer composed of subunits Nu1 and A. The smaller Nu1 terminase subunit has a low-affinity ATPase stimulated by non-specific DNA.


:

Pssm-ID: 369382 [Multi-domain]  Cd Length: 164  Bit Score: 230.31  E-value: 2.91e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959    1 MNVNKKKLADIFGVDVRTITAWQSQGLPLVSGGGKGTESVFDTTAAIQWYAQRESDIENEKLRKEIEDLRAASESDLQPG 80
Cdd:pfam07471   1 MQVNKKGLAEIFGVALRTVDQWQRQGCPVVKGGGKGNEWAFDTAAVIRWYAERDAEIENEKLRREVEELRAAGEADLDPG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959   81 TIDYERYRLTKAQADAQELKNAREEGLVLETELFTYIFQRVAQNISGILVRVPQTLQRKYPDISPAHLDAVKTEIAKASD 160
Cdd:pfam07471  81 TIEYERRRLTAAQADAQELKNADAKKQVAETEQVTKTLARVAAEIAAILRTIPLLLQRRYPRLENRHVDVLLQEIDQALE 160
 
Name Accession Description Interval E-value
Phage_Nu1 pfam07471
Phage DNA packaging protein Nu1; Terminase, the DNA packaging enzyme of bacteriophage lambda, ...
1-160 2.91e-78

Phage DNA packaging protein Nu1; Terminase, the DNA packaging enzyme of bacteriophage lambda, is a heteromultimer composed of subunits Nu1 and A. The smaller Nu1 terminase subunit has a low-affinity ATPase stimulated by non-specific DNA.


Pssm-ID: 369382 [Multi-domain]  Cd Length: 164  Bit Score: 230.31  E-value: 2.91e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959    1 MNVNKKKLADIFGVDVRTITAWQSQGLPLVSGGGKGTESVFDTTAAIQWYAQRESDIENEKLRKEIEDLRAASESDLQPG 80
Cdd:pfam07471   1 MQVNKKGLAEIFGVALRTVDQWQRQGCPVVKGGGKGNEWAFDTAAVIRWYAERDAEIENEKLRREVEELRAAGEADLDPG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959   81 TIDYERYRLTKAQADAQELKNAREEGLVLETELFTYIFQRVAQNISGILVRVPQTLQRKYPDISPAHLDAVKTEIAKASD 160
Cdd:pfam07471  81 TIEYERRRLTAAQADAQELKNADAKKQVAETEQVTKTLARVAAEIAAILRTIPLLLQRRYPRLENRHVDVLLQEIDQALE 160
Nu1 COG4220
Phage DNA packaging protein, Nu1 subunit of terminase [Mobilome: prophages, transposons];
1-181 9.45e-43

Phage DNA packaging protein, Nu1 subunit of terminase [Mobilome: prophages, transposons];


Pssm-ID: 443364  Cd Length: 170  Bit Score: 140.58  E-value: 9.45e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959   1 MNVNKKKLADIFGVDVRTITAWQSQGLPLVSGGGKgtesvFDTTAAIQWYAQRESDIENEKlrkeiedlraasESDLQPG 80
Cdd:COG4220    7 KEVNKAELAELFGVSDRTIDQWARRGIPVVSRRGR-----YDLAAVVRWYIERLREKAAGR------------GSDDQVA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959  81 TIDYERYRLTKAQADAQELKNAREEGLVLETELFTYIFQRVAQNISGILVRVPQTLQRKYPDISPAHLDAVKTEIAKASD 160
Cdd:COG4220   70 DLDAERARLARAQADKAELKNAVMRGELVPAEEVERALSRVAREVRANLLAVPSRLARRLPHLTAADIDVLDREIRKALN 149
                        170       180
                 ....*....|....*....|.
gi 585363959 161 VASEAGENVRRWIDDFRRTEG 181
Cdd:COG4220  150 ELADYDDKLPADLDEYDRADD 170
 
Name Accession Description Interval E-value
Phage_Nu1 pfam07471
Phage DNA packaging protein Nu1; Terminase, the DNA packaging enzyme of bacteriophage lambda, ...
1-160 2.91e-78

Phage DNA packaging protein Nu1; Terminase, the DNA packaging enzyme of bacteriophage lambda, is a heteromultimer composed of subunits Nu1 and A. The smaller Nu1 terminase subunit has a low-affinity ATPase stimulated by non-specific DNA.


Pssm-ID: 369382 [Multi-domain]  Cd Length: 164  Bit Score: 230.31  E-value: 2.91e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959    1 MNVNKKKLADIFGVDVRTITAWQSQGLPLVSGGGKGTESVFDTTAAIQWYAQRESDIENEKLRKEIEDLRAASESDLQPG 80
Cdd:pfam07471   1 MQVNKKGLAEIFGVALRTVDQWQRQGCPVVKGGGKGNEWAFDTAAVIRWYAERDAEIENEKLRREVEELRAAGEADLDPG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959   81 TIDYERYRLTKAQADAQELKNAREEGLVLETELFTYIFQRVAQNISGILVRVPQTLQRKYPDISPAHLDAVKTEIAKASD 160
Cdd:pfam07471  81 TIEYERRRLTAAQADAQELKNADAKKQVAETEQVTKTLARVAAEIAAILRTIPLLLQRRYPRLENRHVDVLLQEIDQALE 160
Nu1 COG4220
Phage DNA packaging protein, Nu1 subunit of terminase [Mobilome: prophages, transposons];
1-181 9.45e-43

Phage DNA packaging protein, Nu1 subunit of terminase [Mobilome: prophages, transposons];


Pssm-ID: 443364  Cd Length: 170  Bit Score: 140.58  E-value: 9.45e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959   1 MNVNKKKLADIFGVDVRTITAWQSQGLPLVSGGGKgtesvFDTTAAIQWYAQRESDIENEKlrkeiedlraasESDLQPG 80
Cdd:COG4220    7 KEVNKAELAELFGVSDRTIDQWARRGIPVVSRRGR-----YDLAAVVRWYIERLREKAAGR------------GSDDQVA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585363959  81 TIDYERYRLTKAQADAQELKNAREEGLVLETELFTYIFQRVAQNISGILVRVPQTLQRKYPDISPAHLDAVKTEIAKASD 160
Cdd:COG4220   70 DLDAERARLARAQADKAELKNAVMRGELVPAEEVERALSRVAREVRANLLAVPSRLARRLPHLTAADIDVLDREIRKALN 149
                        170       180
                 ....*....|....*....|.
gi 585363959 161 VASEAGENVRRWIDDFRRTEG 181
Cdd:COG4220  150 ELADYDDKLPADLDEYDRADD 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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