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Conserved domains on  [gi|558475025|ref|WP_023484233|]
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Lrp/AsnC family transcriptional regulator [Paenibacillus larvae]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-136 9.84e-30

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 104.86  E-value: 9.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475025   5 HLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDIEVEWIHLHQV 84
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558475025  85 IEQLTAAEEITNIYQMSGKPHLHVHALLDDSTHAGK-MMKKLQKIEGITSVQS 136
Cdd:COG1522   82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERfLLERLAALPGVRRTET 134
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-136 9.84e-30

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 104.86  E-value: 9.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475025   5 HLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDIEVEWIHLHQV 84
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558475025  85 IEQLTAAEEITNIYQMSGKPHLHVHALLDDSTHAGK-MMKKLQKIEGITSVQS 136
Cdd:COG1522   82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERfLLERLAALPGVRRTET 134
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-110 2.13e-23

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 87.96  E-value: 2.13e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475025     6 LDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDIEVEW-IHLHQV 84
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENpDKLEEF 80

                           90       100
                   ....*....|....*....|....*.
gi 558475025    85 IEQLTAAEEITNIYQMSGKPHLHVHA 110
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
7-46 1.36e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 55.84  E-value: 1.36e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 558475025    7 DETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHL 46
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRL 40
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-74 9.26e-08

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 48.60  E-value: 9.26e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 558475025   4 KHLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDI 74
Cdd:PRK11169  10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI 80
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-136 9.84e-30

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 104.86  E-value: 9.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475025   5 HLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDIEVEWIHLHQV 84
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDEF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558475025  85 IEQLTAAEEITNIYQMSGKPHLHVHALLDDSTHAGK-MMKKLQKIEGITSVQS 136
Cdd:COG1522   82 AEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERfLLERLAALPGVRRTET 134
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 6-110 2.13e-23

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 87.96  E-value: 2.13e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475025     6 LDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDIEVEW-IHLHQV 84
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENpDKLEEF 80

                           90       100
                   ....*....|....*....|....*.
gi 558475025    85 IEQLTAAEEITNIYQMSGKPHLHVHA 110
Cdd:smart00344  81 LEKLEKLPEVEEVYLVTGDYDYLLKV 106
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
7-46 1.36e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 55.84  E-value: 1.36e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 558475025    7 DETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHL 46
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRL 40
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
8-52 3.33e-08

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 47.04  E-value: 3.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 558475025    8 ETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGII 52
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
4-74 9.26e-08

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 48.60  E-value: 9.26e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 558475025   4 KHLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDI 74
Cdd:PRK11169  10 KDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI 80
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-141 6.71e-06

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 43.16  E-value: 6.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475025   1 MEFKHLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKFTIVVNPLKAGKMLSMYFDIEVEWIH 80
Cdd:PRK11179   2 MENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558475025  81 -LHQVIEQLTAAEEITNIYQMSGKPHLHVhallddsthagKMMKK----LQ-----KIEGITSVQS-EVLIA 141
Cdd:PRK11179  82 dYPSALAKLESLDEVVEAYYTTGHYSIFI-----------KVMCRsidaLQhvlinKIQTIDEIQStETLIS 142
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
5-53 2.05e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 42.60  E-value: 2.05e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 558475025   5 HLDETDTQIIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGIID 53
Cdd:COG2345   10 LADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 3-55 4.34e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 36.82  E-value: 4.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 558475025   3 FKHLDETDTQIIKLLSEN-GRLSHAELGRLIGLTRAALRERVHHLVEDGIIDKF 55
Cdd:COG2512   10 YPELLEDERRVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE 63
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
2-66 1.12e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.42  E-value: 1.12e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558475025     2 EFKHLDETDTQ--IIKLLSENGRLSHAELGRLIGLTRAALRERVHHLVEDGII-------DKFTIVVNPLKAGK 66
Cdd:smart00347   2 ELKPLGLTPTQflVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVrrepspeDRRSVLVSLTEEGR 75
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 80-140 4.18e-03

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 34.04  E-value: 4.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558475025   80 HLHQVIEQLTAAEEITNIYQMSGKPHLHVHALLDDSTHAGK-MMKKLQKIEGITSVQSEVLI 140
Cdd:pfam01037  10 ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERfLREKLRSLPGVARTETSIVL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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