|
Name |
Accession |
Description |
Interval |
E-value |
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
28-492 |
0e+00 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 620.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 28 GIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVERLEGSIPCIVVPDTRRAMAVLADAYYGHPSNAM 107
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAAGVPVIVVPDPRAALALLAAAFYGHPSQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 108 NLIgvtgtngkttttHMIEHIFHHTGHKTGLIGTVSMKLGSYIEKTENTTPESLVLQSMLKRMADREAKYAVLEVSSHAL 187
Cdd:COG0769 81 KLIgvtgtngkttttYLLAQILRALGKKTGLIGTVGNGIGGELIPSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 188 RMGRVRGCNFKTAVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGNSygslpKVAILNADDPFSKKLAAKTSAQVIHYGID 267
Cdd:COG0769 161 DQGRVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPG-----GAAVINADDPYGRRLAAAAPARVITYGLK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 268 QPSDVRASEIRMNQESTSFWLDTYLGSTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETG 347
Cdd:COG0769 236 ADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 348 QDFQVIVDYAHNPDGLEKVISTARAITKGKIIALIGCEGDRDKAKRPIMAAKAAILADKAILTSDNPRSERSESILEDMV 427
Cdd:COG0769 316 QGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADVVIVTSDNPRSEDPAAIIADIL 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558475021 428 RGLDNAGlsRCETITSRKDAIHRALELAKTGDCVLILGKGHETQQIFKDHQIPFDDAEIAMHWLE 492
Cdd:COG0769 396 AGIPGAG--KVLVIPDRAEAIRYAIALAKPGDVVLIAGKGHETYQIIGGVKIPFDDREVAREALA 458
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
23-487 |
0e+00 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 528.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 23 DTEITGIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVERLEGsIPCIVVPDTRRAMAVLADAYYGH 102
Cdd:PRK00139 12 PVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAGTG-VPVIIVPDLRKALALLAAAFYGH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 103 PSNAMNLIgvtgtngkttttHMIEHIFHHTGHKTGLIGTVSMKLGSYIEKTENTTPESLVLQSMLKRMADREAKYAVLEV 182
Cdd:PRK00139 91 PSDKLKLIgvtgtngktttaYLLAQILRLLGEKTALIGTLGNGIGGELIPSGLTTPDALDLQRLLAELVDAGVTYAAMEV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 183 SSHALRMGRVRGCNFKTAVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGNsygslpkVAILNADDPFSKKLAAKTSAQVI 262
Cdd:PRK00139 171 SSHALDQGRVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGL-------AAVINADDEVGRRLLALPDAYAV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 263 HYgidQPSDVRASEIRMNQESTSFWLDtylgsTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQ 342
Cdd:PRK00139 244 SM---AGADLRATDVEYTDSGQTFTLV-----TEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRME 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 343 AIETGQDFQVIVDYAHNPDGLEKVISTARAITKGKIIALIGCEGDRDKAKRPIMAAKAAILADKAILTSDNPRSERSESI 422
Cdd:PRK00139 316 RVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADVVIVTSDNPRSEDPAAI 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558475021 423 LEDMVRGLDnaglsrcETITSRKDAIHRALELAKTGDCVLILGKGHETQQIFKDHQIPFDDAEIA 487
Cdd:PRK00139 396 IADILAGIY-------DVIEDRAEAIRYAIAQAKPGDVVLIAGKGHEDYQIIGGVKIPFDDREVA 453
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
23-484 |
8.14e-165 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 474.50 E-value: 8.14e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 23 DTEITGIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVERLEGSIPCIVVPDTRRAMAVLADAYYGH 102
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVAPVPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 103 PSNAMNLIGVTGTNGKTTTTHMIEHIFHHTGHKTGLIGTVSMKLGSYI---EKTENTTPESLVLQSMLKRMADREAKYAV 179
Cdd:TIGR01085 81 PSKKLKVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYRLGGNDlikNPAALTTPEALTLQSTLAEMVEAGAQYAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 180 LEVSSHALRMGRVRGCNFKTAVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGnsygsLPKVAILNADDPFSKKLAAKTSA 259
Cdd:TIGR01085 161 MEVSSHALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELG-----LKRFAVINLDDEYGAQFVKRLPK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 260 QVIHYGIDQPSDVRASEIRM-----NQESTSFWLDTYLGSTWIHLNVVGIFNVYNALAAIA-VSLVEGIPLEDIKQRLEG 333
Cdd:TIGR01085 236 DITVSAITQPADGRAQDIKItdsgySFEGQQFTFETPAGEGHLHTPLIGRFNVYNLLAALAtLLHLGGIDLEDIVAALEK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 334 FKGVKGRFQAIETGQDFQVIVDYAHNPDGLEKVISTARAITKGKIIALIGCEGDRDKAKRPIMAAKAAILADKAILTSDN 413
Cdd:TIGR01085 316 FRGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILTSDN 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 558475021 414 PRSERSESILEDMVRGLDNAGlsRCETITSRKDAIHRALELAKTGDCVLILGKGHETQQIFKDHQIPFDDA 484
Cdd:TIGR01085 396 PRGEDPEQIIADILAGISEKE--KVVIIADRRQAIRYAISNAKAGDVVLIAGKGHEDYQIIGGETIPFDDR 464
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
33-487 |
1.28e-129 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 399.85 E-value: 1.28e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 33 SGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVERLEGSIPCIV--VPDTRRAMAVLADAYYGHPSNAMNLI 110
Cdd:PRK11929 36 SREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAADALVlpVADLRKALGELAARWYGRPSEQLSLV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 111 GVTGTNGKTTTTHMIEHIFHHTGHKTGLIGTVSMKLGSYIEKTENTTPESLVLQSMLKRMADREAKYAVLEVSSHALRMG 190
Cdd:PRK11929 116 AVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGRLIPGSLTTPDAIILHRILARMRAAGADAVAMEASSHGLEQG 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 191 RVRGCNFKTAVFTNLSHDHLDYHSSMDQYLEDKSILFGQL-GNsygslpKVAILNADDPFSKKLAAKTSA--QVIHYGID 267
Cdd:PRK11929 196 RLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLpGL------GAAVINADDPAAARLLAALPRglKVGYSPQN 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 268 QPSDVRASEIRMNQESTSFWLDTYLGSTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAI--- 344
Cdd:PRK11929 270 AGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERVgpt 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 345 ETGQDFQVIVDYAHNPDGLEKVISTARAIT---KGKIIALIGCEGDRDKAKRPIMAAKAAILADKAILTSDNPRSERSES 421
Cdd:PRK11929 350 AGAQGPLVVVDYAHTPDALAKALTALRPVAqarNGRLVCVFGCGGDRDKGKRPEMGRIAAELADRVVVTSDNPRSEAPEA 429
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558475021 422 ILEDMVRGLDnaGLSRCETITSRKDAIHRALELAKTGDCVLILGKGHETQQIFKDHQIPFDDAEIA 487
Cdd:PRK11929 430 IIDQILAGIP--AGARVFVISDRAEAIRQAIWMAAPGDVILIAGKGHETYQEIGGRKLFFDDREWA 493
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
21-491 |
1.99e-84 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 268.83 E-value: 1.99e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 21 NPDTEITGIKSYSGSVTPGDLFICVPGvlADGHDYVNEAIQRGCAALMAEKKverLEGSIPCIVVPDTRRAMAVLADAYY 100
Cdd:PRK14022 29 YSGVQFDDISYDSRTADEGTLFFAKGA--YFKHKFLQNAITQGLKLYVSEKD---YEVGIPQVIVPDIKKAMSLIAMEFY 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 101 GHPSNAMNLIGVTGTNGKTTTTHMIEHIfHHTGHKTGLIGTVSMKL-GSYIEKTENTTPESLVLQSMLKRMADREAKYAV 179
Cdd:PRK14022 104 DNPQHKLKLLAFTGTKGKTTAAYFAYHI-LKQLHKPAMLSTMNTTLdGETFFKSALTTPESLDLFKMMAEAVDNGMTHLI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 180 LEVSSHALRMGRVRGCNFKTAVFTNLSHDHLDY--HSSMDQYLEDKSILfgqLGNSygslpKVAILNAD-DPFSKKLAAK 256
Cdd:PRK14022 183 MEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPieHPTFEDYFYHKRLL---MENS-----KAVVVNSDmDHFSELLEQV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 257 TSAQVIHYGIDQPSDVRASeirmnqESTSFWLDTYLGSTWiHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGfKG 336
Cdd:PRK14022 255 TPQEHDFYGIDSENQIMAS------NAFSFEATGKLAGTY-DIQLIGKFNQENAMAAGLACLRLGASLEDIQKGIAQ-TP 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 337 VKGRFQAIETGQDFQVIVDYAHNPDGLEKVISTARAITKGKIIALIGCEGDRDKAKRPIMAAKAAILADKA-ILTSDNPR 415
Cdd:PRK14022 327 VPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQvILTADDPN 406
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558475021 416 SERSESILEDMVrgldnAGLSR-CETITSRKDAIHRALELAKT-GDCVLILGKGHETQQIFKDHQIPFD-DAEIAMHWL 491
Cdd:PRK14022 407 NEDPKMITQEIA-----SHITHpVEIIDDRAEAIKHAMSITEGpGDAVIIAGKGADAYQIVPGHRDDYIgDEAAAKKYL 480
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
4-383 |
3.69e-59 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 201.87 E-value: 3.69e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 4 LKLSQLTQdLLVKRMIGNPDTEITGIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVErleGSIPCI 83
Cdd:COG0770 3 LTLAEIAE-ATGGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLP---ADLPLI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 84 VVPDTRRAMAVLAdAYY------------GhpSNamnligvtgtngktttthmiehifhhtGhKTgligTVSMKLGSYIE 151
Cdd:COG0770 79 VVDDTLKALQQLA-AAHrarfnipviaitG--SN---------------------------G-KT----TTKEMLAAVLS 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 152 KTENT--TPESL-----VLQSMLkRMaDREAKYAVLEvsshalrMG-RVRG-----CNF---KTAVFTNLSHDHLDYHSS 215
Cdd:COG0770 124 TKGKVlaTPGNFnneigVPLTLL-RL-PEDHEFAVLE-------MGmNHPGeiaylARIarpDIAVITNIGPAHLEGFGS 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 216 MDQYLEDKSILFGQLGNSygslpKVAILNADDPFSKKLAAKTSAQVIHYGIDQPSDVRASEIRMNQESTSFWLDTYLGST 295
Cdd:COG0770 195 LEGIARAKGEIFEGLPPG-----GVAVLNADDPLLAALAERAKARVLTFGLSEDADVRAEDIELDEDGTRFTLHTPGGEL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 296 WIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETGQDFQVIVD-Y-AhNPDGLEKVISTARAI 373
Cdd:COG0770 270 EVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDsYnA-NPDSMKAALDVLAQL 348
|
410
....*....|.
gi 558475021 374 -TKGKIIALIG 383
Cdd:COG0770 349 pGGGRRIAVLG 359
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
123-316 |
1.09e-56 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 187.51 E-value: 1.09e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 123 HMIEHIFhhtGHKTGLIGTVsmklGSYIEKTENTTPESLVLQSMLKRMADREAKYAVLEVSSHALRMGRVRG-CNFKTAV 201
Cdd:pfam08245 12 ELIAAIL---SLAGGVIGTI----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRLSGlLKPDIAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 202 FTNLSHDHLDYHSSMDQYLEDKSILFGQLGNSYgslpkVAILNADDP---FSKKLAAKTSAQVIHYGIDQPSDVRASEIR 278
Cdd:pfam08245 85 FTNISPDHLDFHGTMENYAKAKAELFEGLPEDG-----IAVINADDPygaFLIAKLKKAGVRVITYGIEGEADLRAANIE 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 558475021 279 MNQESTSFWLDTY-LGSTWIHLNVVGIFNVYNALAAIAV 316
Cdd:pfam08245 160 LSSDGTSFDLFTVpGGELEIEIPLLGRHNVYNALAAIAA 198
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
198-467 |
1.08e-44 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 162.93 E-value: 1.08e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 198 KTAVFTNLSHDHLDYHSSMDQYLEdksiLFGQLGNSygsLPK--VAILNADDPFSKKLAAKTSAQVIHYGIDQPSDVRAS 275
Cdd:COG0773 173 DIAVVTNIEADHLDIYGDLEAIKE----AFHEFARN---VPFygLLVLCADDPGLRELLPRCGRPVITYGFSEDADYRAE 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 276 EIRMNQESTSF---WLDTYLGStwIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETGQDFQV 352
Cdd:COG0773 246 NIRIDGGGSTFdvlRRGEELGE--VELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTV 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 353 IVDYAHNPDGLEKVISTARAI-TKGKIIALIgcegdrdkakRP-------IMA---AKAAILADKAILTSDNP-RSERSE 420
Cdd:COG0773 324 IDDYAHHPTEIAATLAAAREKyPDRRLVAVF----------QPhrysrtrDFLdefAEALSLADEVILLDIYAaREKPIP 393
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 558475021 421 SI-LEDMVRGLDNAGlSRCETITSRKDAIHRALELAKTGDCVLILGKG 467
Cdd:COG0773 394 GVsSEDLAEAIRKRG-KDVVYVPDLDELVEALAEIARPGDVVLTMGAG 440
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
33-383 |
9.24e-34 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 132.00 E-value: 9.24e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 33 SGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVErLEGSIPCIVVPDTRRAMAVLADAYYGHpsNAMNLIGV 112
Cdd:TIGR01143 3 SRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVG-PDNGLPQILVDDTLEALQALARAKRAK--FSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 113 TGTNGKTTTTHMIEHIFHHTG--HKTGligtvsmklGSYieKTENTTPESLVlqsmlkrMADREAKYAVLEvsshalrMG 190
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSHKYkvFATP---------GNF--NNEIGLPLTLL-------RAPGDHDYAVLE-------MG 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 191 RVRGCNFKT---------AVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGNSygslpKVAILNADDPFSKKLAAKTSAQV 261
Cdd:TIGR01143 135 ASHPGEIAYlaeiakpdiAVITNIGPAHLEGFGSLEGIAEAKGEILQGLKEN-----GIAVINADDPAFADLAKRLPNRN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 262 IHYGIDQPSDVRASEIRMNQE-STSFWLDTYLGSTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGR 340
Cdd:TIGR01143 210 ILSFGFEGGDFVAKDISYSALgSTSFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGR 289
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 558475021 341 FQaIETGQDFQVIVD-YAHNPDGLEKVIStARAITKGKIIALIG 383
Cdd:TIGR01143 290 FE-VQTKNGLTLIDDtYNANPDSMRAALD-ALARFPGKKILVLG 331
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
33-465 |
3.45e-31 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 128.28 E-value: 3.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 33 SGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVERLegSIPCIVVPDTRRAMAVLADAYygHPSNAMNLIGV 112
Cdd:PRK11929 533 SRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADV--DLPQIVVDDTRAALGRLATAW--RARFSLPVVAI 608
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 113 TGTNGKTTTTHMIEHIF---HHTGHKTGLIGTVSMKLGsyiektenttpeslVLQSMLKRMADREAkyAVLEVS-SHALR 188
Cdd:PRK11929 609 TGSNGKTTTKEMIAAILaawQGEDRVLATEGNFNNEIG--------------VPLTLLRLRAQHRA--AVFELGmNHPGE 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 189 MGRVRGCNFKT-AVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGNSygslpKVAILNADDPFS---KKLAAKtsAQVIHY 264
Cdd:PRK11929 673 IAYLAAIAAPTvALVTNAQREHQEFMHSVEAVARAKGEIIAALPED-----GVAVVNGDDPYTaiwAKLAGA--RRVLRF 745
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 265 GIDQPSDVRASEIRMN-----QESTSFWLDTYLGSTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKG 339
Cdd:PRK11929 746 GLQPGADVYAEKIAKDisvgeAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAG 825
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 340 RFQAIETGQDFQVIVD-YAHNPDGLEKVISTARAITKGKIIALIGCEGD----RDKAKRPI--MAAKAAIladKAILTSd 412
Cdd:PRK11929 826 RMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGDMLElgdnGPAMHREVgkYARQLGI---DALITL- 901
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 558475021 413 nprserSESILeDMVRGLDNAGLSRCEtitSRKDAIHRALELAKTGDCVLILG 465
Cdd:PRK11929 902 ------GEAAR-DAAAAFGAGARGVCA---SVDEIIAALRGALPEGDSVLIKG 944
|
|
| cya_phycin_syn |
TIGR02068 |
cyanophycin synthetase; Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and ... |
124-464 |
5.00e-31 |
|
cyanophycin synthetase; Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and energy, found in most Cyanobacteria. The polymer has a backbone of L-aspartic acid, with most Asp side chain carboxyl groups attached to L-arginine. The polymer is made by this enzyme, cyanophycin synthetase, and degraded by cyanophycinase. Heterologously expressed cyanophycin synthetase in E. coli produces a closely related, water-soluble polymer with some Arg replaced by Lys. It is unclear whether enzymes that produce soluble cyanophycin-like polymers in vivo in non-Cyanobacterial species should be designated as cyanophycin synthetase itself or as a related enzyme. This model makes the designation as cyanophycin synthetase. Cyanophycin synthesis is analogous to polyhydroxyalkanoic acid (PHA) biosynthesis, except that PHA polymers lack nitrogen and may be made under nitrogen-limiting conditions. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 273950 [Multi-domain] Cd Length: 864 Bit Score: 127.59 E-value: 5.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 124 MIEHIFHHTGHKTGLIGTVSMKLGSY-IEKTENTTPeslvlQSMLKRMADREAKYAVLEVSshalRMGRVR-GCNFKTA- 200
Cdd:TIGR02068 496 LVAHILKQTGKVVGMTTTDGVYIGKYlVEKGDNTGP-----ASARRILMDPTVDAAVLETA----RGGILReGLAFDRCd 566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 201 --VFTNLSHDHL--DYHSSMDQYLEDKSILFGQLgnsygsLPK-VAILNADDPFSKKLAAKTSAQVIHYGIDQPSDVRAS 275
Cdd:TIGR02068 567 vgVVTNIAGDHLgiGDINTIEDLADVKRVVVEVV------LPDgYAVLNADDPMVAAMAEKCKGKIAYFSMDPNNPTVAA 640
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 276 EIRMNQESTSF-----------WLDTYLGSTWIHLNVVG--IFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKG----VK 338
Cdd:TIGR02068 641 HIADGGRAVYYengyiviarggDEVAIARIAAIPLTMGGrvAFQIENALAAVAAAWALGVPIELIRAGIRTFDAdaaqAP 720
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 339 GRFQAIETGqDFQVIVDYAHNPDGLEKVISTARAITKGKIIALIGCEGDRDKAKRPIMAAKAAILADKAILTSDN----- 413
Cdd:TIGR02068 721 GRFNLFNLG-GAHVLVDYGHNPAAIEAVGAAIRNWPARRRIGVIGGPGDRRDEDLVEQGELLGGAFDQIILKEDDdvrgr 799
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 558475021 414 PRSERSESILEDMVRGLDNAglsRCETITSRKDAIHRALELAKTGDCVLIL 464
Cdd:TIGR02068 800 PRGEAAALLRQGLRQSARKA---AIEDILDETEAIAAALDDLRAGDLVVIF 847
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
118-462 |
3.27e-30 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 122.50 E-value: 3.27e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 118 KTTTTHMIEHIFHHTGHKTGL---IGTvsmklgSYIEKTENTTPESLVlqsmlkrmadreakyaVLEVSSHALRmgRVRG 194
Cdd:COG0771 116 KTTTTTLIGHILKAAGLRVAVggnIGT------PLLDLLLEPEPPDVY----------------VLELSSFQLE--TTPS 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 195 CNFKTAVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGNSygslpKVAILNADDPFSKKLAAKTSAQVIHYGIDQPSD--- 271
Cdd:COG0771 172 LRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPD-----DYAVLNADDPLTRALAEEAKARVVPFSLKEPLEgga 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 272 -VRASEIRMNQESTsFWLDTYlgstwiHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIET--Gq 348
Cdd:COG0771 247 gLEDGKLVDRASGE-ELLPVD------DLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEinG- 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 349 dfqviVDY-----AHNPDglekviSTARAIT--KGKIIaLIGceGDRDKAK-----RPIMAAKAAiladKAILT-SDNPR 415
Cdd:COG0771 319 -----VRFindskATNPD------ATLAALEsfDGPVV-LIA--GGLDKGAdfsplAPAVAERVK----AVVLIgEDAEK 380
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 558475021 416 sersesiledMVRGLDNAGLS--RCETItsrKDAIHRALELAKTGDCVL 462
Cdd:COG0771 381 ----------IAAALAGAGVPvvIVETM---EEAVAAAAELARPGDVVL 416
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
170-462 |
2.01e-29 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 120.14 E-value: 2.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 170 MADREAKYAVLEVSSHALRmgRVRGCNFKTAVFTNLSHDHLDYHSSMDQYLEDK-SILFGQlgnsygSLPKVAILNADDP 248
Cdd:TIGR01087 145 LDQEGAELYVLELSSFQLE--TTESLRPEIALILNISEDHLDWHGSFEDYVAAKlKIFARQ------TEGDVAVLNADDP 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 249 FSKKLAAKTSAQVIHYGIDQPSDvRASEIRMNQEstsfwldtYLGSTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIK 328
Cdd:TIGR01087 217 RFARLAQKSKAQVIWFSVEKDAE-RGLCIRDGGL--------YLKPNDLEGSLLGLHNAENILAAIALAKSLGLNLEAIL 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 329 QRLEGFKGVKGRFQAIETGQDFQVIVDY-AHNPDGLEKVISTAraitKGKIIALIGceGDrDK-----AKRPIMAAKAai 402
Cdd:TIGR01087 288 EALRSFKGLPHRLEYVGQKNGVHFYNDSkATNVHATLAALSAF----DNPVILIVG--GD-DKgadfsPLAPAAAGKV-- 358
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558475021 403 ladKAILTsdnpRSERSESILEDmvrgLDNAGLS--RCETITsrkDAIHRALELAKTGDCVL 462
Cdd:TIGR01087 359 ---KAVLA----IGEDAAKIAPL----LKEAGLSvyLVESLE---EAVQAAREVASPGDVVL 406
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
199-467 |
7.40e-28 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 115.87 E-value: 7.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 199 TAVFTNLSHDHLDYHSSMDQYLEDKSILFGQLGNSYGslpkVAILNADDPFSKKLAAKTSAQVIHYGID-QPSDVRASEI 277
Cdd:TIGR01082 169 VAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPFYG----LAVICADDPVLRELVPKATEQVITYGGSgEDADYRAENI 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 278 RMNQESTSFWLDTYLGSTW-IHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETGQDFQVIVDY 356
Cdd:TIGR01082 245 QQSGAEGKFSVRGKGKLYLeFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGEFGGVLLIDDY 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 357 AHNPDGLEKVISTARAITKGK-IIALIgcEGDRDKAKRPIMA--AKAAILADKAILTS------DNPRSERSESILEDM- 426
Cdd:TIGR01082 325 AHHPTEIKATLKAARQGYPDKrIVVVF--QPHRYSRTRDLFDdfAKVLSDADELILLDiyaageEPINGIDGKSLARKIt 402
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 558475021 427 VRGLDNAglsrceTITSRKDAIHRAL-ELAKTGDCVLILGKG 467
Cdd:TIGR01082 403 QLGKIEP------YFVPDLAELVEFLaAVLQSGDLILTMGAG 438
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
337-423 |
4.14e-26 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 101.65 E-value: 4.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 337 VKGRFQAIETGQDFQVIVDYAHNPDGLEKVISTARAITKGKIIALIGCEGDRDKAKRPIMAAKAAILADKAILTSDNPRS 416
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALADVVILTGDYPRA 80
|
....*..
gi 558475021 417 ERSESIL 423
Cdd:pfam02875 81 EDPGAII 87
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-359 |
1.16e-22 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 100.49 E-value: 1.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 1 MNVLKLSQLTqDLLVKRMIGNpDTEITGIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKkveRLEGSI 80
Cdd:PRK10773 1 MISVTLSQLA-DILNGELQGA-DITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSR---PLDIDL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 81 PCIVVPDTRRAMAVLAdAYYGHPSNAmNLIGVTGTNGKTTTTHMIEHIFHHTGHKTGLIGTVSMKLGsyiektentTPES 160
Cdd:PRK10773 76 PQLVVKDTRLAFGQLA-AWVRQQVPA-RVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIG---------VPLT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 161 LVlqsmlkRMADrEAKYAVLEV-SSH----ALRMGRVRGcnfKTAVFTNLSHDHLDYHSSMDQYLEDKsilfgqlGNSYG 235
Cdd:PRK10773 145 LL------RLTP-EHDYAVIELgANHqgeiAYTVSLTRP---EAALVNNLAAAHLEGFGSLAGVAKAK-------GEIFS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 236 SLPK--VAILNADDP----FSKKLAAKTsaqVIHYGIDQPSDVR--ASEIRMNQESTSFWLDTYLGSTWIHLNVVGIFNV 307
Cdd:PRK10773 208 GLPEngIAIMNADSNdwlnWQSVIGSKT---VWRFSPNAANSVDftATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNI 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 558475021 308 YNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETGQDfQVIVDYAHN 359
Cdd:PRK10773 285 ANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPIQLAEG-QLLLDDSYN 335
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
200-465 |
6.08e-20 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 92.09 E-value: 6.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 200 AVFTNLSHDHLDYhssmdqyledksilfgqLGNSygsLPKVA-------------ILNADDP-----FSKKlAAKTSAQV 261
Cdd:COG0285 158 SVITSIGLDHTDF-----------------LGDT---LEEIArekagiikpgvpvVTGDQQPealevIEER-AAELGAPL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 262 IHYGidqpSDVRASEIRMNQESTSFWLDTYLGstwIHLNVVGIFNVYNALAAIAV-----SLVEGIPLEDIKqrlEGFKG 336
Cdd:COG0285 217 YRAG----RDFSVEEREGAVFSYQGPGGEYED---LPLPLLGAHQAENAALALAAlealrELGLPISEEAIR---EGLAN 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 337 VK--GRFQAIETGQDfqVIVDYAHNPDGLEKVIST-ARAITKGKIIALIGCEGDRDKAKrpiMAAKAAILADKAILTS-D 412
Cdd:COG0285 287 ARwpGRLEVLSRGPL--VILDGAHNPAGARALAETlKELFPFRKLHLVFGMLADKDIEG---MLAALAPLADEVIVTTpP 361
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 558475021 413 NPRSERSEsILEDMVRGLDnaglSRCETITSRKDAIHRALELAKTGDCVLILG 465
Cdd:COG0285 362 SPRALDAE-ELAEAARELG----LRVEVAPDVEEALEAALELADPDDLILVTG 409
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
128-463 |
5.84e-18 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 86.18 E-value: 5.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 128 IFHHTGHKTGLIGTVSMKLgsyIEKTENTTPESLVlqsmlkrmadreakyaVLEVSSHALRMgrVRGCNFKTAVFTNLSH 207
Cdd:PRK14106 129 IFKNAGRKTLVAGNIGYPL---IDAVEEYGEDDII----------------VAEVSSFQLET--IKEFKPKVGCILNITP 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 208 DHLDYHSSMDQYLEDKSILFGQLGNSygslpKVAILNADDPFSKKLAAKTSAQVIHYG----IDQPSDVRASEI--RMNQ 281
Cdd:PRK14106 188 DHLDRHKTMENYIKAKARIFENQRPS-----DYTVLNYDDPRTRSLAKKAKARVIFFSrkslLEEGVFVKNGKIviSLGG 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 282 ESTSFwldtylgstwIHLNVVGI---FNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETGQDFQVIVDY-A 357
Cdd:PRK14106 263 KEEEV----------IDIDEIFIpgeHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKFINDSkG 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 358 HNPDGLEKVISTAraitKGKIIaLIGceGDRDK-------AKRPIMAAKAAILAdkailtsdnprSERSESILEDMVRgl 430
Cdd:PRK14106 333 TNPDAAIKALEAY----ETPIV-LIA--GGYDKgsdfdefAKAFKEKVKKLILL-----------GETAQEIAEAARK-- 392
|
330 340 350
....*....|....*....|....*....|...
gi 558475021 431 dnAGLSRCETITSRKDAIHRALELAKTGDCVLI 463
Cdd:PRK14106 393 --YGFDNILFAETLEEAVKKAYEIAKPGDVVLL 423
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
124-342 |
1.19e-16 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 82.90 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 124 MIEHIFHHTGHKTGLIGTVSMKLGSY-IEKTENTTPES--LVLqsmlkrmADREAKYAVLEVSSHA-LRMG----RvrgC 195
Cdd:PRK14016 497 LIAHILKLSGKRVGMTTTDGVYIDGRlIDKGDCTGPKSarRVL-------MNPDVEAAVLETARGGiLREGlaydR---C 566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 196 NfkTAVFTNLSHDHL--DYHSSMDQYLEDKSILfGQLGNSYGslpkVAILNADDPFSKKLAAKTSAQVIHYGIDQPSDVR 273
Cdd:PRK14016 567 D--VGVVTNIGEDHLglGGINTLEDLAKVKRVV-VEAVKPDG----YAVLNADDPMVAAMAERCKGKVIFFSMDPDNPVI 639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 274 ASEIRM-----------------NQESTSFWLDtylgSTWIHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFK- 335
Cdd:PRK14016 640 AEHRAQggravyvegdyivlaegGWEIRIISLA----DIPLTLGGKAGFNIENALAAIAAAWALGIDIELIRAGLRTFVs 715
|
250
....*....|
gi 558475021 336 ---GVKGRFQ 342
Cdd:PRK14016 716 daaQAPGRFN 725
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
198-438 |
1.46e-12 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 70.23 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 198 KTAVFTNLSHDHL-DYHSSMD---QYLEDKSILFGQlgnsygslPKVAILNADDPfskklAAKTSAQVIHYGIDQPSDVR 273
Cdd:PRK14573 172 EFSVITNIDNEHLsNFEGDRElllASIQDFARKVQQ--------INKCFYNGDCP-----RLKGCLQGHSYGFSSSCDLH 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 274 ASEIRMNQESTSFWLdTYLGSTW--IHLNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGRFQAIETGQDFQ 351
Cdd:PRK14573 239 ILSYYQEGWRSYFSA-KFLGVVYqdIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLERKNSSETFL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 352 VIVDYAHNPDGLEKVISTAR-AITKGKIIALigCEGDRDKAKRPIMAA--KAAILADKAILTS--DNPRSERSESILEDM 426
Cdd:PRK14573 318 FLEDYAHHPSEISCTLRAVRdAVGLRRIIAI--CQPHRFSRLRECLDSfpSAFQDADEVILTDvySAGEEPEDSISYQKL 395
|
250
....*....|..
gi 558475021 427 VRGLDNAGLSRC 438
Cdd:PRK14573 396 AEAISQSSIVKC 407
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
10-383 |
3.08e-11 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 65.57 E-value: 3.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 10 TQDLLVKRM----IGNPDTEITGIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCA-ALMAEKKVERLEGSIPCIV 84
Cdd:PRK14093 8 TSDAMAEAMgatrSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAAlAVVERAQRDKFAADAPLLV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 85 VPDTRRAMAVLADAYYGHPSNAMNLIgvtgtngktttthmiehifhhtghkTGLIGTVSMK------LGSYIEKTENT-- 156
Cdd:PRK14093 88 VDDVLAALRDLGRAARARLEAKVIAV-------------------------TGSVGKTSTKealrgvLGAQGETHASVas 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 157 ------TPESLVlqsmlkRMAdREAKYAVLEVS-SHA------LRMGRVRgcnfkTAVFTNLSHDHLDYHSSMDQYLEDK 223
Cdd:PRK14093 143 fnnhwgVPLSLA------RCP-ADARFAVFEIGmNHAgeieplVKMVRPH-----VAIITTVEPVHLEFFSGIEAIADAK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 224 SILFGqlgnsyGSLPK-VAILNADDPFSKKLAAKTSA----QVIHYGIDQPSDVRASEIRMNQESTSFWLDTyLGSTWIH 298
Cdd:PRK14093 211 AEIFT------GLEPGgAAVLNRDNPQFDRLAASARAagiaRIVSFGADEKADARLLDVALHADCSAVHADI-LGHDVTY 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 299 -LNVVGIFNVYNALAAIAVSLVEGIPLEDIKQRLEGFKGVKGR--FQAIETGQDFQVIVD--YAHNPDGLE---KVISTA 370
Cdd:PRK14093 284 kLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRgvRHTLEVGGGEATLIDesYNANPASMAaalGVLGRA 363
|
410
....*....|...
gi 558475021 371 RAITKGKIIALIG 383
Cdd:PRK14093 364 PVGPQGRRIAVLG 376
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
25-100 |
8.50e-10 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 55.32 E-value: 8.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 25 EITGIKSYSGSVTPGDLFICVPGVLADGHDYVNEAIQRGCAALMAEKKVERLEGSIPC--------IVVPDTRRAMAVLA 96
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNISPDNPEleaakvpgIPVIDRREALAELA 80
|
....
gi 558475021 97 DAYY 100
Cdd:pfam01225 81 AAFY 84
|
|
| folC |
TIGR01499 |
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of ... |
98-465 |
2.95e-05 |
|
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273659 [Multi-domain] Cd Length: 397 Bit Score: 46.51 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 98 AYYGHPSNAMNLIGVTGTNGKTTTTHMIEHIFHHTGHKTGLIgtVSMKLGSYIEKT----ENTTPESLV-----LQSMLK 168
Cdd:TIGR01499 9 EALGNPQDLYPVIHVAGTNGKGSTCAFLESILRAAGYKVGLF--TSPHLVSFNERIringEPISDEELAqafeqVRPILE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 169 RM------------------ADREAKYAVLEVSshalrM-GRVRGCNF---KTAVFTNLSHDHLDYhssmdqyledksil 226
Cdd:TIGR01499 87 SLsqqptyfelltllaflyfAQAQVDVAVLEVG-----LgGRLDATNViepLVSVITSIGLDHTEI-------------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 227 fgqLGNSYGSL---------PKVAILNADDPFSKKLAAKTSAQVIHYGIDQ-PSDVRASEIRMNQEStsfWLDTYLGSTW 296
Cdd:TIGR01499 148 ---LGDTLEEIawekagiikEGVPIVTGEQEPEALNVLKKKAQEKGAPLFVvGRDFNYSETDENYLS---FSGANLFLEP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 297 IHLNVVGIFNVYN---ALAAIAVSLVEGIPL--EDIKQRLEGFKgVKGRFQAIETgQDFQVIVDYAHNPDGLEKVISTAR 371
Cdd:TIGR01499 222 LALSLLGDHQQENaalALAALEVLGKQNPKLseEAIRQGLANTI-WPGRLEILSE-DNPNILLDGAHNPHSAEALAEWFK 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 372 AITKGKIIALI-GCEGDRDkAKRPIMAAKAAILADKAILTSDNPRSErsesILEDMVrglDNAGLSRCETITSRKDAIhR 450
Cdd:TIGR01499 300 KRFNGRPITLLfGALADKD-AAAMLAPLKPVVDKEVFVTPFDYPRAD----DAADLA---AFAEETGKSTVEDWREAL-E 370
|
410
....*....|....*
gi 558475021 451 ALELAKTGDCVLILG 465
Cdd:TIGR01499 371 EALNASAEDDILVTG 385
|
|
| LpxD |
COG1044 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ... |
4-106 |
5.47e-05 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 440666 [Multi-domain] Cd Length: 335 Bit Score: 45.39 E-value: 5.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 4 LKLSQLTQdLLVKRMIGNPDTEITGIKSYSgSVTPGDLficvpgVLADGHDYVNEAIQRGCAALMAEKKVERLEGSIPCI 83
Cdd:COG1044 2 FTLAELAE-LLGGELVGDGDLEITGVAPLE-EAGPGDL------SFLANPKYAKQLATTKASAVIVPPDFAAALPGLALI 73
|
90 100
....*....|....*....|...
gi 558475021 84 VVPDTRRAMAVLADAYYGHPSNA 106
Cdd:COG1044 74 VVDNPYLAFAKLLQLFYPPPAPA 96
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
17-99 |
2.64e-04 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 43.79 E-value: 2.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558475021 17 RMIGNPDTEITGIKSYSGSVT--PGDLFICVPGVLADGHDYVNEAIQRGC--AALMAEKKVERLEGSIPCIVVPDTRRAM 92
Cdd:PRK11930 15 EGLGDKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVrnFVVSEEKHPEESYPDANFLKVKDPLKAL 94
|
....*..
gi 558475021 93 AVLADAY 99
Cdd:PRK11930 95 QELAAYH 101
|
|
| |
