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MULTISPECIES: pyruvate dehydrogenase (acetyl-transferring), homodimeric type [Enterobacter]
Protein Classification
pyruvate dehydrogenase (acetyl-transferring), homodimeric type ( domain architecture ID 11484099 )
E1 component of the acetyl-transferring homodimeric-type pyruvate dehydrogenase multienzyme complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2
List of domain hits
Name
Accession
Description
Interval
E-value
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-887
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1949.18
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 1 M SE RLQ ND V DPIET RD WL Q A IE SVIREEG V ERA Q YL ID QLL SE AR KG GV KVASG A g ASN Y V NTI A VE D EPEYPG N L D LER 80
Cdd:PRK09405 4 G SE SQL ND I DPIET QE WL E A LD SVIREEG P ERA H YL LE QLL ER AR EK GV SLPAS A - TTP Y I NTI P VE E EPEYPG D L E LER 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 81 RIRS A IRWNA IMT VLRA S KKDL E LGGH MA SF Q SSAT V YEV C FNHFFRA A NE KD GGDLV Y FQGH I SPGIYARAFLEGRLTE 160
Cdd:PRK09405 83 RIRS Y IRWNA AAM VLRA N KKDL G LGGH IS SF A SSAT L YEV G FNHFFRA P NE PH GGDLV F FQGH A SPGIYARAFLEGRLTE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 161 EQ MN NFRQEV H GKGLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K FLKYLE H RGLKDTS E Q T V Y AFLGDGEMDEPES K 240
Cdd:PRK09405 163 EQ LD NFRQEV D GKGLSSYPHP W LMP D FWQFPTVSMGLGPI M AIYQA R FLKYLE N RGLKDTS D Q K V W AFLGDGEMDEPES L 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 241 GAI TI A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELEGIF A GAGWNVIKV M WG G RWD E LL R KDTSGKL I QLMNETVD 320
Cdd:PRK09405 243 GAI SL A A REKLDNL I F V INCNLQRLDGPV R GNGKII Q ELEGIF R GAGWNVIKV I WG S RWD P LL A KDTSGKL V QLMNETVD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 321 GDYQT F K S KDGAYVREHFFGKYPET A ALVAD WT D EQ IWALNRGGHDP K KVYAA L K K A R E T KG KA TVILA H TIKGYGMG DT 400
Cdd:PRK09405 323 GDYQT Y K A KDGAYVREHFFGKYPET K ALVAD MS D DD IWALNRGGHDP R KVYAA Y K A A V E H KG QP TVILA K TIKGYGMG EA 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 401 A EGKNIAHQVKK MNM D GVRYI RDRFN V P VT DEQ V E N L S Y ITFP E G S E E H KYLHERR Q AL K GYLPAR Q P N F t E K LE L PAL E 480
Cdd:PRK09405 403 G EGKNIAHQVKK LDL D DLKHF RDRFN I P IS DEQ L E K L P Y YKPG E D S P E I KYLHERR K AL G GYLPAR R P K F - E P LE V PAL S 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 481 D F SQ LL EEQNK - EISTT I AFVR A LN VM LK N K S I KD R L VPII A DEARTFGMEGLFRQIGIY S P N GQ Q YTP Q DR E Q VA YYKE 559
Cdd:PRK09405 482 A F EA LL KGSGE r EISTT M AFVR I LN IL LK D K E I GK R I VPII P DEARTFGMEGLFRQIGIY N P H GQ L YTP V DR D Q LM YYKE 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 560 DEK GQILQEGINE L GA G ASW L AAATSYST NNL PMIPFYIYYSMFGFQRIGDL C W Q AGDQ Q ARGFL V GGT S GRTTLNGEGL 639
Cdd:PRK09405 562 SKD GQILQEGINE A GA M ASW I AAATSYST HGE PMIPFYIYYSMFGFQRIGDL A W A AGDQ R ARGFL L GGT A GRTTLNGEGL 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 640 QHEDGHSHI QSL TIPNC I SYDP SY AYEVAVI MH DGL Q RMYGE a QEN IY YYIT TL NENYH M PAMP A GAEEGI R KG I YKLET 719
Cdd:PRK09405 642 QHEDGHSHI LAS TIPNC V SYDP AF AYEVAVI VQ DGL R RMYGE - QEN VF YYIT VM NENYH Q PAMP E GAEEGI L KG M YKLET 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 720 L EG S KGK -- VQLLGSG S ILR H V R EAA Q ILA K DYGV GS DV Y SVTSF T ELARDGQD C ERWNMLHP L E T PRVPY IA QV MND A - 796
Cdd:PRK09405 721 A EG K KGK pk VQLLGSG T ILR E V L EAA E ILA E DYGV AA DV W SVTSF N ELARDGQD V ERWNMLHP T E E PRVPY VT QV LKG A e 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 797 - P A VA S TDYMKLFAEQ V R TY VP A d DY R VLGTDGFGRSD S RE N LR HH FEVDA S YVVVAAL GE LA KR GEID KK VVA D AI T K F 875
Cdd:PRK09405 801 g P V VA A TDYMKLFAEQ I R AF VP G - DY V VLGTDGFGRSD T RE A LR RF FEVDA E YVVVAAL KA LA DE GEID AS VVA E AI K K Y 879
890
....*....|..
gi 556486791 876 N ID AE K V NPR L A 887
Cdd:PRK09405 880 G ID PD K A NPR T A 891
Name
Accession
Description
Interval
E-value
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-887
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1949.18
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 1 M SE RLQ ND V DPIET RD WL Q A IE SVIREEG V ERA Q YL ID QLL SE AR KG GV KVASG A g ASN Y V NTI A VE D EPEYPG N L D LER 80
Cdd:PRK09405 4 G SE SQL ND I DPIET QE WL E A LD SVIREEG P ERA H YL LE QLL ER AR EK GV SLPAS A - TTP Y I NTI P VE E EPEYPG D L E LER 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 81 RIRS A IRWNA IMT VLRA S KKDL E LGGH MA SF Q SSAT V YEV C FNHFFRA A NE KD GGDLV Y FQGH I SPGIYARAFLEGRLTE 160
Cdd:PRK09405 83 RIRS Y IRWNA AAM VLRA N KKDL G LGGH IS SF A SSAT L YEV G FNHFFRA P NE PH GGDLV F FQGH A SPGIYARAFLEGRLTE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 161 EQ MN NFRQEV H GKGLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K FLKYLE H RGLKDTS E Q T V Y AFLGDGEMDEPES K 240
Cdd:PRK09405 163 EQ LD NFRQEV D GKGLSSYPHP W LMP D FWQFPTVSMGLGPI M AIYQA R FLKYLE N RGLKDTS D Q K V W AFLGDGEMDEPES L 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 241 GAI TI A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELEGIF A GAGWNVIKV M WG G RWD E LL R KDTSGKL I QLMNETVD 320
Cdd:PRK09405 243 GAI SL A A REKLDNL I F V INCNLQRLDGPV R GNGKII Q ELEGIF R GAGWNVIKV I WG S RWD P LL A KDTSGKL V QLMNETVD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 321 GDYQT F K S KDGAYVREHFFGKYPET A ALVAD WT D EQ IWALNRGGHDP K KVYAA L K K A R E T KG KA TVILA H TIKGYGMG DT 400
Cdd:PRK09405 323 GDYQT Y K A KDGAYVREHFFGKYPET K ALVAD MS D DD IWALNRGGHDP R KVYAA Y K A A V E H KG QP TVILA K TIKGYGMG EA 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 401 A EGKNIAHQVKK MNM D GVRYI RDRFN V P VT DEQ V E N L S Y ITFP E G S E E H KYLHERR Q AL K GYLPAR Q P N F t E K LE L PAL E 480
Cdd:PRK09405 403 G EGKNIAHQVKK LDL D DLKHF RDRFN I P IS DEQ L E K L P Y YKPG E D S P E I KYLHERR K AL G GYLPAR R P K F - E P LE V PAL S 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 481 D F SQ LL EEQNK - EISTT I AFVR A LN VM LK N K S I KD R L VPII A DEARTFGMEGLFRQIGIY S P N GQ Q YTP Q DR E Q VA YYKE 559
Cdd:PRK09405 482 A F EA LL KGSGE r EISTT M AFVR I LN IL LK D K E I GK R I VPII P DEARTFGMEGLFRQIGIY N P H GQ L YTP V DR D Q LM YYKE 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 560 DEK GQILQEGINE L GA G ASW L AAATSYST NNL PMIPFYIYYSMFGFQRIGDL C W Q AGDQ Q ARGFL V GGT S GRTTLNGEGL 639
Cdd:PRK09405 562 SKD GQILQEGINE A GA M ASW I AAATSYST HGE PMIPFYIYYSMFGFQRIGDL A W A AGDQ R ARGFL L GGT A GRTTLNGEGL 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 640 QHEDGHSHI QSL TIPNC I SYDP SY AYEVAVI MH DGL Q RMYGE a QEN IY YYIT TL NENYH M PAMP A GAEEGI R KG I YKLET 719
Cdd:PRK09405 642 QHEDGHSHI LAS TIPNC V SYDP AF AYEVAVI VQ DGL R RMYGE - QEN VF YYIT VM NENYH Q PAMP E GAEEGI L KG M YKLET 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 720 L EG S KGK -- VQLLGSG S ILR H V R EAA Q ILA K DYGV GS DV Y SVTSF T ELARDGQD C ERWNMLHP L E T PRVPY IA QV MND A - 796
Cdd:PRK09405 721 A EG K KGK pk VQLLGSG T ILR E V L EAA E ILA E DYGV AA DV W SVTSF N ELARDGQD V ERWNMLHP T E E PRVPY VT QV LKG A e 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 797 - P A VA S TDYMKLFAEQ V R TY VP A d DY R VLGTDGFGRSD S RE N LR HH FEVDA S YVVVAAL GE LA KR GEID KK VVA D AI T K F 875
Cdd:PRK09405 801 g P V VA A TDYMKLFAEQ I R AF VP G - DY V VLGTDGFGRSD T RE A LR RF FEVDA E YVVVAAL KA LA DE GEID AS VVA E AI K K Y 879
890
....*....|..
gi 556486791 876 N ID AE K V NPR L A 887
Cdd:PRK09405 880 G ID PD K A NPR T A 891
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1899.42
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 1 MS ERLQ ---- N D V DP I ET RD WL QAIES VI R EEG V ERA Q YL IDQ LL SE AR KG GV KVASG A g ASN Y V NTI A VE D EP E YPG NL 76
Cdd:COG2609 1 MS MDGL psql P D I DP Q ET QE WL ESLDA VI E EEG P ERA R YL LER LL ER AR RS GV GLPFS A - TTP Y I NTI P VE Q EP P YPG DE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 77 D LERRIRS A IRWNA IMT V L RA SK K DLE LGGH MA SF Q S S AT V YEV C FNHFFR AANEKD GGDLVYFQGH I SPGIYARAFLEG 156
Cdd:COG2609 80 E LERRIRS I IRWNA MAM V V RA NR K GGG LGGH IS SF A S A AT L YEV G FNHFFR GPDHPG GGDLVYFQGH A SPGIYARAFLEG 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 157 RLTEEQ MN NFRQEV H GKGLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K F L KYL EH RGLKDTS EQT V Y AFLGDGEMDE 236
Cdd:COG2609 160 RLTEEQ LD NFRQEV D GKGLSSYPHP W LMP D FWQFPTVSMGLGPI N AIYQA R F M KYL HN RGLKDTS DRK V W AFLGDGEMDE 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 237 PES K GAI TI A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELEG I F A GAGWNVIKV M WG GR WD E LL R KDT S G K L IQL MN 316
Cdd:COG2609 240 PES L GAI SL A A REKLDNL I F V INCNLQRLDGPV R GNGKII Q ELEG V F R GAGWNVIKV I WG SE WD P LL A KDT D G A L VKR MN 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 317 ETVDGDYQT F K S KDGAYVREHFFGKYPE TA ALVAD WT DE Q IW A LNRGGHDP K KVYAA L K K A R E T KG KA TVILA H TIKGYG 396
Cdd:COG2609 320 ETVDGDYQT Y K A KDGAYVREHFFGKYPE LK ALVAD MS DE D IW R LNRGGHDP R KVYAA Y K A A V E H KG QP TVILA K TIKGYG 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 397 MG DTA EG K NI A HQ V KK MNM D GVRYI RDRFN V P VT DEQ V E N L S Y ITFP E G S E E H KYLHERR Q AL K GYLP A R QPN f T E K LE L 476
Cdd:COG2609 400 MG EAG EG R NI T HQ Q KK LDL D DLKAF RDRFN I P IS DEQ L E E L P Y YKPA E D S P E M KYLHERR K AL G GYLP Q R RTK - A E P LE V 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 477 P A L ED F SQ LL E - EQNK EISTT I AFVR A LN VM LK N K S I KD R L VPI IA DEARTFGMEGLFRQIGIYSP N GQ Q YTP Q D RE Q VA 555
Cdd:COG2609 479 P E L SA F AA LL K g SGKR EISTT M AFVR I LN DL LK D K E I GK R I VPI VP DEARTFGMEGLFRQIGIYSP V GQ L YTP V D AD Q LL 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 556 YYKE DEK GQILQEGINE L GA GA SW L AA A TSYST NNL PMIPFYIYYSMFGFQR I GDL C W Q AGDQ Q ARGFL V G G T S GRTTLN 635
Cdd:COG2609 559 YYKE SKD GQILQEGINE A GA MS SW I AA G TSYST HGV PMIPFYIYYSMFGFQR V GDL A W A AGDQ R ARGFL I G A T A GRTTLN 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 636 GEGLQH E DGHSH IQSL TIPNC I SYDP SY AYE V AVI MH DGL Q RMYGE a QEN IY YYIT TL NENY HM PAMP A G A EEGI R KG I Y 715
Cdd:COG2609 639 GEGLQH Q DGHSH LLAS TIPNC V SYDP AF AYE L AVI VQ DGL R RMYGE - QEN VF YYIT VM NENY AQ PAMP E G V EEGI L KG M Y 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 716 K L ETL EG - S K GK VQLLGSG S ILR H V RE AA QI LA K D Y GV GS DV Y SVTSF T EL A RDG Q D C ERWN M LHP L E T PRVPY IA Q VMN 794
Cdd:COG2609 718 L L KEG EG k G K PR VQLLGSG T ILR E V LA AA EL LA E D W GV AA DV W SVTSF N EL R RDG L D V ERWN L LHP E E E PRVPY VT Q CLA 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 795 D A -- P A VA S TDYM KLFAE Q V R TY VP A d D Y R VLGTDGFGRSD S RE N LR HH FEVD ASYV VVAAL GE LA KR G E ID KK VVA D AI 872
Cdd:COG2609 798 G A eg P V VA A TDYM RAVPD Q I R PW VP G - R Y T VLGTDGFGRSD T RE A LR RF FEVD RYSI VVAAL KA LA DE G K ID AS VVA E AI 876
890
....*....|....*
gi 556486791 873 T K FN ID AE K V NP RL A 887
Cdd:COG2609 877 K K YG ID PD K P NP LT A 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
4-887
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1662.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 4 RLQ NDVDPIET RD WL QAIE SV IR EEG VE RA Q YL ID QLL SE AR KG GV KVAS G A g ASN Y V NTI A VE DE P E YPG N L D LERRIR 83
Cdd:TIGR00759 1 SQP NDVDPIET QE WL ESLD SV LA EEG PA RA R YL LE QLL EY AR EH GV PIPA G T - TTD Y I NTI P VE EQ P A YPG D L E LERRIR 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 84 S A IRWNAI MT VLRA S KKDL E LGGH MASFQ S S AT V YEV C FNHFFR AAN E KD GGDLV Y FQGH IS PGIYARAFLEGRLTEEQ M 163
Cdd:TIGR00759 80 S I IRWNAI AM VLRA N KKDL G LGGH ISTYA S A AT L YEV G FNHFFR GHS E GG GGDLV F FQGH AA PGIYARAFLEGRLTEEQ L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 164 N NFRQEV H G K GLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K F L KYLE H RGLKDT SE Q T V Y AFLGDGEMDEPESKGAI 243
Cdd:TIGR00759 160 D NFRQEV Q G D GLSSYPHP W LMP D FWQFPTVSMGLGPI N AIYQA R F M KYLE N RGLKDT GD Q K V W AFLGDGEMDEPESKGAI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 244 T I A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELE GI F A GAGWNVIKV M WG GR WD E LL RK DTSG K L IQ LMNETVDGDY 323
Cdd:TIGR00759 240 T F A A REKLDNL T F V INCNLQRLDGPV R GNGKII Q ELE SL F R GAGWNVIKV L WG SE WD A LL AR DTSG V L VK LMNETVDGDY 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 324 QT F K S KDGAYVREHFF GKY PE TA ALVAD WT D EQ IWALNRGGHDP K KVYAA LKK A R E T KG KA TVILA H TIKGYGMGD T AE G 403
Cdd:TIGR00759 320 QT Y K A KDGAYVREHFF NRT PE LK ALVAD MS D AD IWALNRGGHDP R KVYAA YAA A Q E H KG QP TVILA K TIKGYGMGD A AE S 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 404 K N I AHQVKK MNM D GVRYI RDRF NV P VT D E QVE N L S Y ITFP EGS E E HK YL HE RRQAL K GYLPAR QP n F T E K L EL PALE D F S 483
Cdd:TIGR00759 400 R N T AHQVKK LEV D ALKNF RDRF EL P LS D A QVE E L P Y YHPG EGS P E VR YL LA RRQAL G GYLPAR RT - F A E H L TV PALE F F G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 484 Q LL EEQ - NK E I STT I AFVR A LN VM LK N K S I KD R L VPI IA DEARTFGMEGLFRQIGIYSP N GQ Q YTP Q D REQVAY YKE DEK 562
Cdd:TIGR00759 479 A LL KGS g ER E V STT M AFVR I LN KL LK D K E I GK R I VPI VP DEARTFGMEGLFRQIGIYSP H GQ T YTP V D ADSLLA YKE SKD 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 563 GQILQEGINE L GA G ASW L AAATSY S T NNL PMIPFYIYYSMFGFQRIGDLCW Q A G DQ Q ARGFL V G G T S GRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINE A GA M ASW I AAATSY A T HGE PMIPFYIYYSMFGFQRIGDLCW A A A DQ R ARGFL L G A T A GRTTLNGEGLQHE 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 643 DGHS HI Q SL TIPNCI S YDP SY AYEVAVIM H DGL Q RMYGE a QE NIY YY I T TL NENY HM P A MP A GAEEGI R KG I Y KL E -- T L 720
Cdd:TIGR00759 639 DGHS LL Q AA TIPNCI A YDP AF AYEVAVIM E DGL R RMYGE - QE DVF YY V T VM NENY VQ P P MP E GAEEGI L KG L Y RF E ts T E 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 721 E GS KG K VQLLGSG S I L R H V R EAAQ I LA K D Y GV G SDV Y SVTSFTELARDG Q D C ERWN M LHP L ETPRV P Y I AQV M N -- DAP A 798
Cdd:TIGR00759 718 E KA KG H VQLLGSG A I M R A V I EAAQ L LA A D W GV A SDV W SVTSFTELARDG H D V ERWN L LHP T ETPRV S Y V AQV L N ea DAP V 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 799 V ASTDY MKL FAEQ V R T YVP a DD Y RV LGTDGFGRSD S RENLRH H FEVDA SY VV V AAL GE LA KR GEID KK VVADAI T K FN ID 878
Cdd:TIGR00759 798 I ASTDY VRA FAEQ I R P YVP - RK Y VT LGTDGFGRSD T RENLRH F FEVDA KS VV L AAL YA LA DD GEID GD VVADAI A K YG ID 876
....*....
gi 556486791 879 AE K V NP RLA 887
Cdd:TIGR00759 877 PD K A NP VYR 885
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
76-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 745.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 76 L DL ERRIRS A IRWNA IMT V L RA S KKDL EL GGH M A S F Q S S AT V YEV C FNHFFRA AN E KD GGDLVYFQGH I SPGIYARAFLE 155
Cdd:cd02017 1 L EI ERRIRS L IRWNA MAM V H RA N KKDL GI GGH I A T F A S A AT L YEV G FNHFFRA RG E GG GGDLVYFQGH A SPGIYARAFLE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 156 GRLTEEQ MN NFRQEV H G K GLSSYPHP K LMP E FW Q FPTVSMGLGPI G AIYQA K F LK YLE H RGLKDTS E Q T V Y AFLGDGEMD 235
Cdd:cd02017 81 GRLTEEQ LD NFRQEV G G G GLSSYPHP W LMP D FW E FPTVSMGLGPI Q AIYQA R F NR YLE D RGLKDTS D Q K V W AFLGDGEMD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 236 EPES K GAI TI A T REKLDNL C F II NCNLQRLDGPV T GNGKII N ELEGIF A GAGWNVIKV M WG GR WDELL R KD TS G K L I Q L M 315
Cdd:cd02017 161 EPES L GAI GL A A REKLDNL I F VV NCNLQRLDGPV R GNGKII Q ELEGIF R GAGWNVIKV I WG SK WDELL A KD GG G A L R Q R M 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 316 N ETVDGDYQT F K S KDGAYVREHFFGKYPE TA ALV A D WT DE QI WALNRGGHDP K KVYAA L KKA R E T KGK A TVILA H TIKGY 395
Cdd:cd02017 241 E ETVDGDYQT L K A KDGAYVREHFFGKYPE LK ALV T D LS DE DL WALNRGGHDP R KVYAA Y KKA V E H KGK P TVILA K TIKGY 320
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556486791 396 G M G DTA EG K N I AHQVKKM NM D GVRYI RDRF NV PV T DEQ V E NLS Y ITF PEGSEE H KYLHERR Q AL K G 461
Cdd:cd02017 321 G L G AAG EG R N H AHQVKKM TE D ELKAL RDRF GI PV S DEQ L E EGP Y YKP PEGSEE I KYLHERR H AL G G 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
474-700
3.92e-108
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 332.47
E-value: 3.92e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 474 LE L P A L E D --- F SQ LLEEQNK EISTT I AFVR A LN VML K N K S I KDRL VPII A DEARTFGMEG L FRQ I GIY SPN GQ Q Y T P Q D 550
Cdd:pfam17831 1 LE I P D L D D kif A SQ TGGSKGR EISTT M AFVR I LN GLV K D K K I GKQV VPII P DEARTFGMEG M FRQ L GIY TSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 551 RE Q VAY Y K ED EK GQIL Q EGI N E L GA GAS W L AAATSYS TN N LPMI PFY I YYSMFGFQRIGDL C W Q AGD Q QARGFLVGGT S G 630
Cdd:pfam17831 81 KG Q IMF Y R ED KQ GQIL E EGI S E A GA MSA W I AAATSYS NH N TTLL PFY V YYSMFGFQRIGDL A W A AGD M QARGFLVGGT A G 160
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 631 RTTLNGEGLQH E DGHSHIQ SL TIPNC I SYDP S YA Y EVAVI MH DGL Q RM YGE a Q EN IY YY I T TL NENY HM P 700
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQ AS TIPNC R SYDP T YA H EVAVI VQ DGL K RM FAD - K EN CF YY L T VM NENY EH P 229
Name
Accession
Description
Interval
E-value
aceE
PRK09405 pyruvate dehydrogenase subunit E1; Reviewed
1-887
0e+00
pyruvate dehydrogenase subunit E1; Reviewed
Pssm-ID: 236500 [Multi-domain]
Cd Length: 891
Bit Score: 1949.18
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 1 M SE RLQ ND V DPIET RD WL Q A IE SVIREEG V ERA Q YL ID QLL SE AR KG GV KVASG A g ASN Y V NTI A VE D EPEYPG N L D LER 80
Cdd:PRK09405 4 G SE SQL ND I DPIET QE WL E A LD SVIREEG P ERA H YL LE QLL ER AR EK GV SLPAS A - TTP Y I NTI P VE E EPEYPG D L E LER 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 81 RIRS A IRWNA IMT VLRA S KKDL E LGGH MA SF Q SSAT V YEV C FNHFFRA A NE KD GGDLV Y FQGH I SPGIYARAFLEGRLTE 160
Cdd:PRK09405 83 RIRS Y IRWNA AAM VLRA N KKDL G LGGH IS SF A SSAT L YEV G FNHFFRA P NE PH GGDLV F FQGH A SPGIYARAFLEGRLTE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 161 EQ MN NFRQEV H GKGLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K FLKYLE H RGLKDTS E Q T V Y AFLGDGEMDEPES K 240
Cdd:PRK09405 163 EQ LD NFRQEV D GKGLSSYPHP W LMP D FWQFPTVSMGLGPI M AIYQA R FLKYLE N RGLKDTS D Q K V W AFLGDGEMDEPES L 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 241 GAI TI A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELEGIF A GAGWNVIKV M WG G RWD E LL R KDTSGKL I QLMNETVD 320
Cdd:PRK09405 243 GAI SL A A REKLDNL I F V INCNLQRLDGPV R GNGKII Q ELEGIF R GAGWNVIKV I WG S RWD P LL A KDTSGKL V QLMNETVD 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 321 GDYQT F K S KDGAYVREHFFGKYPET A ALVAD WT D EQ IWALNRGGHDP K KVYAA L K K A R E T KG KA TVILA H TIKGYGMG DT 400
Cdd:PRK09405 323 GDYQT Y K A KDGAYVREHFFGKYPET K ALVAD MS D DD IWALNRGGHDP R KVYAA Y K A A V E H KG QP TVILA K TIKGYGMG EA 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 401 A EGKNIAHQVKK MNM D GVRYI RDRFN V P VT DEQ V E N L S Y ITFP E G S E E H KYLHERR Q AL K GYLPAR Q P N F t E K LE L PAL E 480
Cdd:PRK09405 403 G EGKNIAHQVKK LDL D DLKHF RDRFN I P IS DEQ L E K L P Y YKPG E D S P E I KYLHERR K AL G GYLPAR R P K F - E P LE V PAL S 481
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 481 D F SQ LL EEQNK - EISTT I AFVR A LN VM LK N K S I KD R L VPII A DEARTFGMEGLFRQIGIY S P N GQ Q YTP Q DR E Q VA YYKE 559
Cdd:PRK09405 482 A F EA LL KGSGE r EISTT M AFVR I LN IL LK D K E I GK R I VPII P DEARTFGMEGLFRQIGIY N P H GQ L YTP V DR D Q LM YYKE 561
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 560 DEK GQILQEGINE L GA G ASW L AAATSYST NNL PMIPFYIYYSMFGFQRIGDL C W Q AGDQ Q ARGFL V GGT S GRTTLNGEGL 639
Cdd:PRK09405 562 SKD GQILQEGINE A GA M ASW I AAATSYST HGE PMIPFYIYYSMFGFQRIGDL A W A AGDQ R ARGFL L GGT A GRTTLNGEGL 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 640 QHEDGHSHI QSL TIPNC I SYDP SY AYEVAVI MH DGL Q RMYGE a QEN IY YYIT TL NENYH M PAMP A GAEEGI R KG I YKLET 719
Cdd:PRK09405 642 QHEDGHSHI LAS TIPNC V SYDP AF AYEVAVI VQ DGL R RMYGE - QEN VF YYIT VM NENYH Q PAMP E GAEEGI L KG M YKLET 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 720 L EG S KGK -- VQLLGSG S ILR H V R EAA Q ILA K DYGV GS DV Y SVTSF T ELARDGQD C ERWNMLHP L E T PRVPY IA QV MND A - 796
Cdd:PRK09405 721 A EG K KGK pk VQLLGSG T ILR E V L EAA E ILA E DYGV AA DV W SVTSF N ELARDGQD V ERWNMLHP T E E PRVPY VT QV LKG A e 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 797 - P A VA S TDYMKLFAEQ V R TY VP A d DY R VLGTDGFGRSD S RE N LR HH FEVDA S YVVVAAL GE LA KR GEID KK VVA D AI T K F 875
Cdd:PRK09405 801 g P V VA A TDYMKLFAEQ I R AF VP G - DY V VLGTDGFGRSD T RE A LR RF FEVDA E YVVVAAL KA LA DE GEID AS VVA E AI K K Y 879
890
....*....|..
gi 556486791 876 N ID AE K V NPR L A 887
Cdd:PRK09405 880 G ID PD K A NPR T A 891
AceE
COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion] ...
1-887
0e+00
Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Pyruvate dehydrogenase complex, dehydrogenase (E1) component is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 442021 [Multi-domain]
Cd Length: 891
Bit Score: 1899.42
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 1 MS ERLQ ---- N D V DP I ET RD WL QAIES VI R EEG V ERA Q YL IDQ LL SE AR KG GV KVASG A g ASN Y V NTI A VE D EP E YPG NL 76
Cdd:COG2609 1 MS MDGL psql P D I DP Q ET QE WL ESLDA VI E EEG P ERA R YL LER LL ER AR RS GV GLPFS A - TTP Y I NTI P VE Q EP P YPG DE 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 77 D LERRIRS A IRWNA IMT V L RA SK K DLE LGGH MA SF Q S S AT V YEV C FNHFFR AANEKD GGDLVYFQGH I SPGIYARAFLEG 156
Cdd:COG2609 80 E LERRIRS I IRWNA MAM V V RA NR K GGG LGGH IS SF A S A AT L YEV G FNHFFR GPDHPG GGDLVYFQGH A SPGIYARAFLEG 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 157 RLTEEQ MN NFRQEV H GKGLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K F L KYL EH RGLKDTS EQT V Y AFLGDGEMDE 236
Cdd:COG2609 160 RLTEEQ LD NFRQEV D GKGLSSYPHP W LMP D FWQFPTVSMGLGPI N AIYQA R F M KYL HN RGLKDTS DRK V W AFLGDGEMDE 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 237 PES K GAI TI A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELEG I F A GAGWNVIKV M WG GR WD E LL R KDT S G K L IQL MN 316
Cdd:COG2609 240 PES L GAI SL A A REKLDNL I F V INCNLQRLDGPV R GNGKII Q ELEG V F R GAGWNVIKV I WG SE WD P LL A KDT D G A L VKR MN 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 317 ETVDGDYQT F K S KDGAYVREHFFGKYPE TA ALVAD WT DE Q IW A LNRGGHDP K KVYAA L K K A R E T KG KA TVILA H TIKGYG 396
Cdd:COG2609 320 ETVDGDYQT Y K A KDGAYVREHFFGKYPE LK ALVAD MS DE D IW R LNRGGHDP R KVYAA Y K A A V E H KG QP TVILA K TIKGYG 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 397 MG DTA EG K NI A HQ V KK MNM D GVRYI RDRFN V P VT DEQ V E N L S Y ITFP E G S E E H KYLHERR Q AL K GYLP A R QPN f T E K LE L 476
Cdd:COG2609 400 MG EAG EG R NI T HQ Q KK LDL D DLKAF RDRFN I P IS DEQ L E E L P Y YKPA E D S P E M KYLHERR K AL G GYLP Q R RTK - A E P LE V 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 477 P A L ED F SQ LL E - EQNK EISTT I AFVR A LN VM LK N K S I KD R L VPI IA DEARTFGMEGLFRQIGIYSP N GQ Q YTP Q D RE Q VA 555
Cdd:COG2609 479 P E L SA F AA LL K g SGKR EISTT M AFVR I LN DL LK D K E I GK R I VPI VP DEARTFGMEGLFRQIGIYSP V GQ L YTP V D AD Q LL 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 556 YYKE DEK GQILQEGINE L GA GA SW L AA A TSYST NNL PMIPFYIYYSMFGFQR I GDL C W Q AGDQ Q ARGFL V G G T S GRTTLN 635
Cdd:COG2609 559 YYKE SKD GQILQEGINE A GA MS SW I AA G TSYST HGV PMIPFYIYYSMFGFQR V GDL A W A AGDQ R ARGFL I G A T A GRTTLN 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 636 GEGLQH E DGHSH IQSL TIPNC I SYDP SY AYE V AVI MH DGL Q RMYGE a QEN IY YYIT TL NENY HM PAMP A G A EEGI R KG I Y 715
Cdd:COG2609 639 GEGLQH Q DGHSH LLAS TIPNC V SYDP AF AYE L AVI VQ DGL R RMYGE - QEN VF YYIT VM NENY AQ PAMP E G V EEGI L KG M Y 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 716 K L ETL EG - S K GK VQLLGSG S ILR H V RE AA QI LA K D Y GV GS DV Y SVTSF T EL A RDG Q D C ERWN M LHP L E T PRVPY IA Q VMN 794
Cdd:COG2609 718 L L KEG EG k G K PR VQLLGSG T ILR E V LA AA EL LA E D W GV AA DV W SVTSF N EL R RDG L D V ERWN L LHP E E E PRVPY VT Q CLA 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 795 D A -- P A VA S TDYM KLFAE Q V R TY VP A d D Y R VLGTDGFGRSD S RE N LR HH FEVD ASYV VVAAL GE LA KR G E ID KK VVA D AI 872
Cdd:COG2609 798 G A eg P V VA A TDYM RAVPD Q I R PW VP G - R Y T VLGTDGFGRSD T RE A LR RF FEVD RYSI VVAAL KA LA DE G K ID AS VVA E AI 876
890
....*....|....*
gi 556486791 873 T K FN ID AE K V NP RL A 887
Cdd:COG2609 877 K K YG ID PD K P NP LT A 891
aceE
TIGR00759 pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are ...
4-887
0e+00
pyruvate dehydrogenase E1 component, homodimeric type; Most members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
Pssm-ID: 273255 [Multi-domain]
Cd Length: 885
Bit Score: 1662.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 4 RLQ NDVDPIET RD WL QAIE SV IR EEG VE RA Q YL ID QLL SE AR KG GV KVAS G A g ASN Y V NTI A VE DE P E YPG N L D LERRIR 83
Cdd:TIGR00759 1 SQP NDVDPIET QE WL ESLD SV LA EEG PA RA R YL LE QLL EY AR EH GV PIPA G T - TTD Y I NTI P VE EQ P A YPG D L E LERRIR 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 84 S A IRWNAI MT VLRA S KKDL E LGGH MASFQ S S AT V YEV C FNHFFR AAN E KD GGDLV Y FQGH IS PGIYARAFLEGRLTEEQ M 163
Cdd:TIGR00759 80 S I IRWNAI AM VLRA N KKDL G LGGH ISTYA S A AT L YEV G FNHFFR GHS E GG GGDLV F FQGH AA PGIYARAFLEGRLTEEQ L 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 164 N NFRQEV H G K GLSSYPHP K LMP E FWQFPTVSMGLGPI G AIYQA K F L KYLE H RGLKDT SE Q T V Y AFLGDGEMDEPESKGAI 243
Cdd:TIGR00759 160 D NFRQEV Q G D GLSSYPHP W LMP D FWQFPTVSMGLGPI N AIYQA R F M KYLE N RGLKDT GD Q K V W AFLGDGEMDEPESKGAI 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 244 T I A T REKLDNL C F I INCNLQRLDGPV T GNGKII N ELE GI F A GAGWNVIKV M WG GR WD E LL RK DTSG K L IQ LMNETVDGDY 323
Cdd:TIGR00759 240 T F A A REKLDNL T F V INCNLQRLDGPV R GNGKII Q ELE SL F R GAGWNVIKV L WG SE WD A LL AR DTSG V L VK LMNETVDGDY 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 324 QT F K S KDGAYVREHFF GKY PE TA ALVAD WT D EQ IWALNRGGHDP K KVYAA LKK A R E T KG KA TVILA H TIKGYGMGD T AE G 403
Cdd:TIGR00759 320 QT Y K A KDGAYVREHFF NRT PE LK ALVAD MS D AD IWALNRGGHDP R KVYAA YAA A Q E H KG QP TVILA K TIKGYGMGD A AE S 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 404 K N I AHQVKK MNM D GVRYI RDRF NV P VT D E QVE N L S Y ITFP EGS E E HK YL HE RRQAL K GYLPAR QP n F T E K L EL PALE D F S 483
Cdd:TIGR00759 400 R N T AHQVKK LEV D ALKNF RDRF EL P LS D A QVE E L P Y YHPG EGS P E VR YL LA RRQAL G GYLPAR RT - F A E H L TV PALE F F G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 484 Q LL EEQ - NK E I STT I AFVR A LN VM LK N K S I KD R L VPI IA DEARTFGMEGLFRQIGIYSP N GQ Q YTP Q D REQVAY YKE DEK 562
Cdd:TIGR00759 479 A LL KGS g ER E V STT M AFVR I LN KL LK D K E I GK R I VPI VP DEARTFGMEGLFRQIGIYSP H GQ T YTP V D ADSLLA YKE SKD 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 563 GQILQEGINE L GA G ASW L AAATSY S T NNL PMIPFYIYYSMFGFQRIGDLCW Q A G DQ Q ARGFL V G G T S GRTTLNGEGLQHE 642
Cdd:TIGR00759 559 GQILQEGINE A GA M ASW I AAATSY A T HGE PMIPFYIYYSMFGFQRIGDLCW A A A DQ R ARGFL L G A T A GRTTLNGEGLQHE 638
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 643 DGHS HI Q SL TIPNCI S YDP SY AYEVAVIM H DGL Q RMYGE a QE NIY YY I T TL NENY HM P A MP A GAEEGI R KG I Y KL E -- T L 720
Cdd:TIGR00759 639 DGHS LL Q AA TIPNCI A YDP AF AYEVAVIM E DGL R RMYGE - QE DVF YY V T VM NENY VQ P P MP E GAEEGI L KG L Y RF E ts T E 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 721 E GS KG K VQLLGSG S I L R H V R EAAQ I LA K D Y GV G SDV Y SVTSFTELARDG Q D C ERWN M LHP L ETPRV P Y I AQV M N -- DAP A 798
Cdd:TIGR00759 718 E KA KG H VQLLGSG A I M R A V I EAAQ L LA A D W GV A SDV W SVTSFTELARDG H D V ERWN L LHP T ETPRV S Y V AQV L N ea DAP V 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 799 V ASTDY MKL FAEQ V R T YVP a DD Y RV LGTDGFGRSD S RENLRH H FEVDA SY VV V AAL GE LA KR GEID KK VVADAI T K FN ID 878
Cdd:TIGR00759 798 I ASTDY VRA FAEQ I R P YVP - RK Y VT LGTDGFGRSD T RENLRH F FEVDA KS VV L AAL YA LA DD GEID GD VVADAI A K YG ID 876
....*....
gi 556486791 879 AE K V NP RLA 887
Cdd:TIGR00759 877 PD K A NP VYR 885
PRK13012
PRK13012 2-oxoacid dehydrogenase subunit E1; Provisional
7-884
0e+00
2-oxoacid dehydrogenase subunit E1; Provisional
Pssm-ID: 237267 [Multi-domain]
Cd Length: 896
Bit Score: 1499.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 7 N D V DP I ET RD WL Q A IES V IREE G V ERA Q YL I D Q LL SE A RKG G VKVA s G AGASN YVNTI A V EDE P E YPG N L D LE R R IRSA I 86
Cdd:PRK13012 18 P D I DP Q ET AE WL E A LDA V VAHA G P ERA R YL L D R LL ER A AAR G IALP - G LLTTP YVNTI P V DQQ P P YPG D L A LE E R LAAI I 96
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 87 RWNA IMT V L RA SKKDL ELGGH M AS FQ S S A TVY EV C FNHFFR AANEKD GGDLVYFQ G H IS PGIYARAFLEGRL T EEQ MNN F 166
Cdd:PRK13012 97 RWNA LAM V V RA NRAYG ELGGH I AS YA S A A DLF EV G FNHFFR GRDDAG GGDLVYFQ P H SA PGIYARAFLEGRL S EEQ LDH F 176
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 167 RQE VH G K GLSSYPHP K LMP E FWQFPT V SMG L GPI G AIYQA K F LK YL E HRGLKDTS EQT V YA F L GDGEMDEPES KG A ITI A 246
Cdd:PRK13012 177 RQE IG G P GLSSYPHP W LMP D FWQFPT G SMG I GPI N AIYQA R F MR YL Q HRGLKDTS GRK V WG F F GDGEMDEPES IA A LSL A 256
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 247 T RE K LDNL C F I INCNLQRLDGPV T GNG K II N ELE GI F A GAGWNVIKV M WG GR WD E L LRK DT S G K L IQLMN ETVDG DY QTF 326
Cdd:PRK13012 257 A RE G LDNL V F V INCNLQRLDGPV R GNG R II Q ELE AL F R GAGWNVIKV L WG SD WD A L FAR DT T G A L VRRFA ETVDG QF QTF 336
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 327 K SK DGAY V REHFFG KY PE T AALVA DWT DE Q I WA L N RGGHDP K KVYAA LKK A RET KG KA TVILA H T I KGYGMG DTA EG KNI 406
Cdd:PRK13012 337 K AN DGAY N REHFFG QD PE L AALVA HLS DE D I DR L K RGGHDP R KVYAA YAA A VRH KG QP TVILA K T K KGYGMG EAG EG RMT 416
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 407 A HQ V KK MNMDGVRYI RDRF NV P VT DEQ V E N L SYITFP E G S E E HK YLH E RR Q AL K GYLP A R QPN f TEK L EL P A L ED F S Q - L 485
Cdd:PRK13012 417 T HQ Q KK LDVEALKAF RDRF RL P LS DEQ L E Q L PFYKPA E D S P E MR YLH A RR A AL G GYLP R R RTA - APP L PV P P L SA F A Q f A 495
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 486 L EEQN KE I STT I AFVR A L NVM LK N K SIKD R L VPI I ADEARTFGM EG LFRQ I GIYSP N GQ Q Y T P Q D REQVA YY K E DEK GQI 565
Cdd:PRK13012 496 L GAGG KE M STT M AFVR M L GNL LK D K ALGP R I VPI V ADEARTFGM AN LFRQ V GIYSP L GQ L Y E P E D AGSLL YY R E AKD GQI 575
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 566 L Q EGI N E L GA GA SW L AAATSYS TNN LPM I PFYIYYSMFGFQR I GDL C W Q A G DQ Q ARGFL V G G T S GRTTL N GEGLQH E DGH 645
Cdd:PRK13012 576 L E EGI T E A GA IS SW I AAATSYS VHG LPM L PFYIYYSMFGFQR V GDL I W A A A DQ R ARGFL L G A T A GRTTL G GEGLQH Q DGH 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 646 SH IQSL TIPNC IS YDP SY AYE V AVI MH DG LQ RM YG E a QE NIY YY I T TL NENY HM PA M P A GAEEGI R KG I Y K L e TLEGSKG 725
Cdd:PRK13012 656 SH LLAS TIPNC RA YDP AF AYE L AVI VD DG MR RM LE E - QE DVF YY L T VM NENY AQ PA L P E GAEEGI L KG M Y R L - AAAAEAP 733
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 726 K VQLLGSG S ILR H V RE AA QI LA K D Y GV GS DV Y SVTSFTEL A RDG QDC ER W N M L H P L E TP RVPY IA Q VMNDA -- P A VA S TD 803
Cdd:PRK13012 734 R VQLLGSG A ILR E V LA AA RL LA D D W GV DA DV W SVTSFTEL R RDG LAA ER A N L L G P A E EA RVPY VT Q CLAGT rg P V VA A TD 813
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 804 Y MKLFA EQ V R TY VPA d D Y RV LGTDGFGRSD S R EN LR HH FEVD ASYV V V AAL GE LA KR GE IDKK VVA D AI TKFN ID AE K VN 883
Cdd:PRK13012 814 Y VRAVP EQ I R AF VPA - R Y VT LGTDGFGRSD T R AA LR RF FEVD RHSI V L AAL KA LA DD GE VERT VVA E AI ERYG ID DD K TP 892
.
gi 556486791 884 P 884
Cdd:PRK13012 893 P 893
AKGDH_not_PDH
TIGR03186 alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric ...
8-875
0e+00
alpha-ketoglutarate dehydrogenase; Several bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
Pssm-ID: 132230 [Multi-domain]
Cd Length: 889
Bit Score: 1131.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 8 D V DP I ET RD WL Q A IES V IREE G V ERAQYL ID QL LSE A RKG G VK v ASG AGA SN YVNTIAV ED EP E YPG N L D LE R R IRSAI R 87
Cdd:TIGR03186 5 D T DP Q ET AE WL D A LDG V VAHA G A ERAQYL LA QL AAH A ARL G LA - PPA AGA TP YVNTIAV DQ EP P YPG D L Q LE E R LAAIL R 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 88 WNA IMT V L RA SKKDL ELGGH M AS FQ S S A TVY EV C FNHFFRAA NEKD GGDLVYFQ G H IS PG I YARAFLEG R L TEE Q MNNF R 167
Cdd:TIGR03186 84 WNA LAM V V RA NRAYG ELGGH I AS YA S A A DLF EV G FNHFFRAA GDAS GGDLVYFQ P H SA PG V YARAFLEG F L SDA Q LAHY R 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 168 QE VH G K GL S SYPHP K LMP E FWQFPT V SMG L GPI G AIYQA K F LK YL EH RGL KD T SEQT V YA F L GDGEMDEPES K GA ITI A T 247
Cdd:TIGR03186 164 QE IA G P GL C SYPHP W LMP D FWQFPT G SMG I GPI N AIYQA R F MR YL QN RGL AR T EGRK V WG F F GDGEMDEPES I GA LSL A A 243
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 248 RE K LDNL C F I INCNLQRLDGPV T GNG K II N ELE GI FAGAGWNVIKV M WG GR WD E L LRK D TS G K L IQLMNE TVDG DY QTF K 327
Cdd:TIGR03186 244 RE R LDNL V F V INCNLQRLDGPV R GNG R II D ELE SQ FAGAGWNVIKV L WG SD WD A L FAR D AT G A L ARAFAH TVDG QF QTF S 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 328 SK DGAY V R EH FFG KY P ET AALVA DWT DE Q I WA L N RGGHD PK K V YAA LKK A RETK G KA TVILA H T I KG Y GMG DTAE G KNIA 407
Cdd:TIGR03186 324 AN DGAY N R AR FFG QD P AL AALVA HLS DE D I DR L R RGGHD AR K L YAA YDR A VRHE G RP TVILA K T M KG F GMG AIGQ G RMTT 403
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 408 HQ V KK MNMDGVRYI RDRF NV P VT D EQ VE N L SYITFP E G S E E HK YLH E RR Q AL K GYLP A R QPNF T EK L EL PAL EDFSQL - L 486
Cdd:TIGR03186 404 HQ Q KK LDVEALLAF RDRF RL P LS D AD VE Q L KFYKPD E D S A E MR YLH A RR A AL G GYLP R R RTAA T HA L AV PAL PSWGRF a L 483
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 487 EEQN KE I STT I A F VR A L NVM LK NKSIKD R L VPI I ADEARTFGM EG LFRQ I GIYSP N GQ Q Y T P Q D REQVA YY K ED EK GQIL 566
Cdd:TIGR03186 484 DAEG KE M STT M A I VR M L GAL LK DAELGP R I VPI V ADEARTFGM AN LFRQ V GIYSP L GQ R Y E P E D LGSML YY R ED TD GQIL 563
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 567 Q EGI N E L GA GA SW L AAATSYS TNN LPM I PFYIYYSMFGFQRIGDL C W Q A G DQ Q ARGFL V G G TSG R TTL N GEGLQH E DG H S 646
Cdd:TIGR03186 564 E EGI S E A GA IS SW I AAATSYS VHD LPM L PFYIYYSMFGFQRIGDL I W A A A DQ R ARGFL I G A TSG K TTL G GEGLQH Q DG T S 643
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 647 H IQSL T I PNC ISY DP SY AYEVAVI MHD G LQR M YGE a Q ENIY YY I T TL NENY HM P AM P AGAEEGI R K GI Y K ---- L ETLEG 722
Cdd:TIGR03186 644 H LAAS T V PNC RAW DP AF AYEVAVI VDE G MRE M LER - Q RDEF YY L T VT NENY AQ P SL P EDRLDAV R R GI L K gmyp L DPAAL 722
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 723 SKGK VQLLGSG S IL RH V RE AA QI L AK D Y G VGSD V Y SVTSFTELARDG QDC ER WNM L HPL E T P RV P YI AQ VM -- NDA P AV A 800
Cdd:TIGR03186 723 AAAR VQLLGSG A IL GE V QA AA RL L RD D W G IDAA V W SVTSFTELARDG RAA ER AQR L GDA E R P PS P HV AQ AL ga TQG P VI A 802
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556486791 801 S TDY MKLFA E QV R T YVP A d D Y RV LGTDGFGRSD S R EN LR HH FEVD ASYV V V AAL GE LA KR G EIDKK VV AD AI TKF 875
Cdd:TIGR03186 803 A TDY VRAVP E LI R A YVP R - R Y VT LGTDGFGRSD T R AA LR AF FEVD RASI V I AAL QA LA DD G LVARD VV RQ AI ARY 876
TPP_E1_EcPDC_like
cd02017 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; ...
76-461
0e+00
Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using TPP and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme.
Pssm-ID: 238975 [Multi-domain]
Cd Length: 386
Bit Score: 745.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 76 L DL ERRIRS A IRWNA IMT V L RA S KKDL EL GGH M A S F Q S S AT V YEV C FNHFFRA AN E KD GGDLVYFQGH I SPGIYARAFLE 155
Cdd:cd02017 1 L EI ERRIRS L IRWNA MAM V H RA N KKDL GI GGH I A T F A S A AT L YEV G FNHFFRA RG E GG GGDLVYFQGH A SPGIYARAFLE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 156 GRLTEEQ MN NFRQEV H G K GLSSYPHP K LMP E FW Q FPTVSMGLGPI G AIYQA K F LK YLE H RGLKDTS E Q T V Y AFLGDGEMD 235
Cdd:cd02017 81 GRLTEEQ LD NFRQEV G G G GLSSYPHP W LMP D FW E FPTVSMGLGPI Q AIYQA R F NR YLE D RGLKDTS D Q K V W AFLGDGEMD 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 236 EPES K GAI TI A T REKLDNL C F II NCNLQRLDGPV T GNGKII N ELEGIF A GAGWNVIKV M WG GR WDELL R KD TS G K L I Q L M 315
Cdd:cd02017 161 EPES L GAI GL A A REKLDNL I F VV NCNLQRLDGPV R GNGKII Q ELEGIF R GAGWNVIKV I WG SK WDELL A KD GG G A L R Q R M 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 316 N ETVDGDYQT F K S KDGAYVREHFFGKYPE TA ALV A D WT DE QI WALNRGGHDP K KVYAA L KKA R E T KGK A TVILA H TIKGY 395
Cdd:cd02017 241 E ETVDGDYQT L K A KDGAYVREHFFGKYPE LK ALV T D LS DE DL WALNRGGHDP R KVYAA Y KKA V E H KGK P TVILA K TIKGY 320
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556486791 396 G M G DTA EG K N I AHQVKKM NM D GVRYI RDRF NV PV T DEQ V E NLS Y ITF PEGSEE H KYLHERR Q AL K G 461
Cdd:cd02017 321 G L G AAG EG R N H AHQVKKM TE D ELKAL RDRF GI PV S DEQ L E EGP Y YKP PEGSEE I KYLHERR H AL G G 386
PDH_E1_M
pfam17831 Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin ...
474-700
3.92e-108
Pyruvate dehydrogenase E1 component middle domain; This entry represents one of the thiamin diphosphate-binding domains found in pyruvate dehydrogenase E1 component.
Pssm-ID: 465525 [Multi-domain]
Cd Length: 229
Bit Score: 332.47
E-value: 3.92e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 474 LE L P A L E D --- F SQ LLEEQNK EISTT I AFVR A LN VML K N K S I KDRL VPII A DEARTFGMEG L FRQ I GIY SPN GQ Q Y T P Q D 550
Cdd:pfam17831 1 LE I P D L D D kif A SQ TGGSKGR EISTT M AFVR I LN GLV K D K K I GKQV VPII P DEARTFGMEG M FRQ L GIY TSE GQ K Y E P V D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 551 RE Q VAY Y K ED EK GQIL Q EGI N E L GA GAS W L AAATSYS TN N LPMI PFY I YYSMFGFQRIGDL C W Q AGD Q QARGFLVGGT S G 630
Cdd:pfam17831 81 KG Q IMF Y R ED KQ GQIL E EGI S E A GA MSA W I AAATSYS NH N TTLL PFY V YYSMFGFQRIGDL A W A AGD M QARGFLVGGT A G 160
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 631 RTTLNGEGLQH E DGHSHIQ SL TIPNC I SYDP S YA Y EVAVI MH DGL Q RM YGE a Q EN IY YY I T TL NENY HM P 700
Cdd:pfam17831 161 RTTLNGEGLQH Q DGHSHIQ AS TIPNC R SYDP T YA H EVAVI VQ DGL K RM FAD - K EN CF YY L T VM NENY EH P 229
TPP_TK
cd02012 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK ...
85-408
7.34e-23
Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the pentose phosphate pathway and provides precursors for nucleotide, aromatic amino acid and vitamin biosynthesis. In addition, the enzyme plays a central role in the Calvin cycle in plants. Typically, TKs are homodimers. They require TPP and divalent cations, such as magnesium ions, for activity.
Pssm-ID: 238970 [Multi-domain]
Cd Length: 255
Bit Score: 98.73
E-value: 7.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 85 A IR WNA I MT V LR A S kkdlel G GH MASFQ S S A TVYE V CFNHFFR -- A A NE K DGGDLVYFQ -- GH I SP GI YA RAF L E G R L T E 160
Cdd:cd02012 2 R IR RLS I DM V QK A G ------ S GH PGGSL S A A DILA V LYFKVLK yd P A DP K WPNRDRFVL sk GH A SP AL YA VLA L A G Y L P E 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 161 E QMNN FRQ evhgk GL S SY P - HP klmp E FWQF P T V SMGL G P -------- I G AIYQA K F L K ylehrglkdt SEQT VY AF LGD 231
Cdd:cd02012 76 E DLKT FRQ ----- LG S RL P g HP ---- E YGLT P G V EVTT G S lgqglsva V G MALAE K L L G ---------- FDYR VY VL LGD 136
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 232 GE MD E PESKG A ITI A TRE KLDNL CF I INC N LQRL DGP v T GNGKIINE L EGI F AGA GWNVI K V mwggrwdellrkdtsgkl 311
Cdd:cd02012 137 GE LQ E GSVWE A ASF A GHY KLDNL IA I VDS N RIQI DGP - T DDILFTED L AKK F EAF GWNVI E V ------------------ 197
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 312 iqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnr G GHD PKKVY AAL KK A RET KGK A T V I L A H T 391
Cdd:cd02012 198 --------------------------------------------------- D GHD VEEIL AAL EE A KKS KGK P T L I I A K T 226
330
....*....|....*..
gi 556486791 392 IKG Y G M g DTA E GKNIA H 408
Cdd:cd02012 227 IKG K G V - PFM E NTAKW H 242
PRK05899
PRK05899 transketolase; Reviewed
75-408
6.60e-17
transketolase; Reviewed
Pssm-ID: 235639 [Multi-domain]
Cd Length: 586
Bit Score: 85.19
E-value: 6.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 75 NLD L ERRIRS AIR WNA I MT V LR A S kkdlel G GH MASFQSS A TVYE V CFNH F F R -- AA N E K DGG - D - L V YFQ GH I S PGI Y A 150
Cdd:PRK05899 4 DME L LQLLAN AIR VLS I DA V QK A N ------ S GH PGMPMGA A DIAY V LWTR F L R hd PK N P K WPN r D r F V LSA GH G S MLL Y S 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 151 RAF L E G - R L TEEQMN NFRQ ev H G kgl S SY P - HP klmp E FWQF P T V SMGL GP I G ----- A IYQ A KFL KYL EHRGLKDTSEQ 223
Cdd:PRK05899 78 LLH L A G y D L SIDDLK NFRQ -- L G --- S KT P g HP ---- E YGHT P G V ETTT GP L G qglan A VGM A LAE KYL AALFNRPGLDI 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 224 T --- V Y AFL GDG EMD E PE S KG A ITI A TRE KL D NL CF I INC N - LQ r L DGP VT G ngk IIN E - LEGI F AGA GW N VI K V mwggr 298
Cdd:PRK05899 149 V dhy T Y VLC GDG DLM E GI S HE A CSL A GHL KL G NL IV I YDD N r IS - I DGP TE G --- WFT E d VKKR F EAY GW H VI E V ----- 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 299 w D ellrkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrg GHD PKKVY AA LKK A R 378
Cdd:PRK05899 220 - D --------------------------------------------------------------- GHD VEAID AA IEE A K 235
330 340 350
....*....|....*....|....*....|
gi 556486791 379 ETK g K A T V I L A H TI K G Y G MG d TA EG KNIA H 408
Cdd:PRK05899 236 AST - K P T L I I A K TI I G K G AP - NK EG THKV H 263
Transketolase_N
pfam00456 Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes ...
79-408
9.04e-10
Transketolase, thiamine diphosphate binding domain; This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit EC:1.2.4.4. Both these enzymes utilize thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.
Pssm-ID: 395366 [Multi-domain]
Cd Length: 334
Bit Score: 61.25
E-value: 9.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 79 ER R IRS AIR WN A IMT V LR A S kkdlel G GH MASFQSS A TVY EV C F NH F FR -- AANE K -- DGGDL V YFQ GH I S PGI Y ARAF L 154
Cdd:pfam00456 2 DK R AVN AIR AL A MDA V EK A N ------ S GH PGAPMGM A PIA EV L F KR F LK hn PNDP K wi NRDRF V LSN GH G S MLL Y SLLH L 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 155 E G - R L TE E QMNN FRQ e VH gkgl S SY P - HP klmp EF WQFPT V SMGL GP I G --------- AI YQAKFLKYLEHR G L k D TSEQ 223
Cdd:pfam00456 76 T G y D L SM E DLKS FRQ - LG ---- S KT P g HP ---- EF GHTAG V EVTT GP L G qgianavgm AI AERNLAATYNRP G F - D IVDH 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 224 TV Y A FLGDG EMD E PE S KG A ITI A TREK L D NL CFIINC N LQRL DG PV tg NGKIINELEGI F AGA GW N VI K V mwggrwdell 303
Cdd:pfam00456 146 YT Y V FLGDG CLM E GV S SE A SSL A GHLG L G NL IVFYDD N QISI DG ET -- KISFTEDTAAR F EAY GW H VI E V ---------- 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 304 rkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwaln RG GHD PKKVY AA LKK A RET K G K 383
Cdd:pfam00456 214 ---------------------------------------------------------- ED GHD VEAIA AA IEE A KAE K D K 235
330 340
....*....|....*....|....*
gi 556486791 384 A T V I LAH T IK GYG m GDTAE G KNIA H 408
Cdd:pfam00456 236 P T L I KCR T VI GYG - SPNKQ G THDV H 259
TktA
COG0021 Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway ...
225-408
5.26e-06
Transketolase [Carbohydrate transport and metabolism]; Transketolase is part of the Pathway/BioSystem: Pentose phosphate pathway
Pssm-ID: 439792 [Multi-domain]
Cd Length: 661
Bit Score: 50.01
E-value: 5.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 225 V Y AFL GDG EMD E PE S KG A ITI A TRE KL DN L CFIINC N LQRL DG PVTG ngk IIN E - LEGI F AGA GW N VI K V MW G grwdell 303
Cdd:COG0021 149 T Y VIA GDG DLM E GI S HE A ASL A GHL KL GK L IVLYDD N GISI DG DTDL --- AFS E d VAKR F EAY GW H VI R V ED G ------- 218
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 304 rkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeqiwalnrgg HD PKKVY AA LKK A RETKG K 383
Cdd:COG0021 219 ------------------------------------------------------------- HD LEAID AA IEA A KAETD K 237
170 180
....*....|....*....|....*
gi 556486791 384 A T V I LAH TI K GYG MG d TAE G KNI AH 408
Cdd:COG0021 238 P T L I ICK TI I GYG SP - NKQ G TAK AH 261
PTZ00089
PTZ00089 transketolase; Provisional
142-293
1.62e-03
transketolase; Provisional
Pssm-ID: 173383 [Multi-domain]
Cd Length: 661
Bit Score: 41.97
E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 142 GH I S PGI Y ARAF L E G R - L TE E QMN NFRQ EV hgkgl S SY P - HP klmp E FWQF P T V SMGL GP I G - A I YQ A KF L KYL E H ---- 214
Cdd:PTZ00089 67 GH A S ALL Y SMLH L T G Y d L SM E DLK NFRQ LG ----- S RT P g HP ---- E RHIT P G V EVTT GP L G q G I AN A VG L AIA E K hlaa 137
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556486791 215 --- R GLKDTSEQT VY AFL GDG EMD E PE S KG A ITI A TREK L DN L CFIINC N LQRL DG PV tgngk IINEL E GI --- FAGA GW 288
Cdd:PTZ00089 138 kfn R PGHPIFDNY VY VIC GDG CLQ E GV S QE A LSL A GHLG L EK L IVLYDD N KITI DG NT ----- DLSFT E DV ekk YEAY GW 212
....*
gi 556486791 289 N VI K V 293
Cdd:PTZ00089 213 H VI E V 217
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
