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Conserved domains on  [gi|556425477|ref|WP_023310404|]
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MULTISPECIES: DNA gyrase inhibitor YacG [Enterobacter]

Protein Classification

DNA gyrase inhibitor YacG( domain architecture ID 10011432)

DNA gyrase inhibitor YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA

Gene Symbol:  yacG
Gene Ontology:  GO:0008270|GO:0008657
PubMed:  18586829

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
1-61 2.23e-36

DNA gyrase inhibitor YacG;


:

Pssm-ID: 234754  Cd Length: 62  Bit Score: 115.90  E-value: 2.23e-36
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556425477  1 MSDVTTVSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLSDSDDWSE 61
Cdd:PRK00418  1 MSETITVNCPTCGKPVEWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSE 61
 
Name Accession Description Interval E-value
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
1-61 2.23e-36

DNA gyrase inhibitor YacG;


Pssm-ID: 234754  Cd Length: 62  Bit Score: 115.90  E-value: 2.23e-36
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556425477  1 MSDVTTVSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLSDSDDWSE 61
Cdd:PRK00418  1 MSETITVNCPTCGKPVEWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSE 61
YacG COG3024
Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair]; ...
 5-61 2.31e-28

Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair];


Pssm-ID: 442260  Cd Length: 58  Bit Score: 95.42  E-value: 2.31e-28
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 556425477  5 TTVSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLSDSDDWSE 61
Cdd:COG3024   2 TKVPCPICGKPVEWSPENPYRPFCSKRCKLIDLGRWLSEEYRIPGEPLDDDEEDPEE 58
YacG pfam03884
DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by ...
 7-54 1.70e-23

DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.


Pssm-ID: 427566  Cd Length: 48  Bit Score: 83.08  E-value: 1.70e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 556425477   7 VSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLS 54
Cdd:pfam03884  1 VRCPTCGKPVEWSPENPFRPFCSERCKLIDLGAWADEEYRIPGEPPPD 48
 
Name Accession Description Interval E-value
PRK00418 PRK00418
DNA gyrase inhibitor YacG;
1-61 2.23e-36

DNA gyrase inhibitor YacG;


Pssm-ID: 234754  Cd Length: 62  Bit Score: 115.90  E-value: 2.23e-36
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556425477  1 MSDVTTVSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLSDSDDWSE 61
Cdd:PRK00418  1 MSETITVNCPTCGKPVEWGEISPFRPFCSKRCQLIDLGEWAAEEKRIPSSGDLSESDDWSE 61
YacG COG3024
Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair]; ...
 5-61 2.31e-28

Endogenous inhibitor of DNA gyrase, YacG/DUF329 family [Replication, recombination and repair];


Pssm-ID: 442260  Cd Length: 58  Bit Score: 95.42  E-value: 2.31e-28
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 556425477  5 TTVSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLSDSDDWSE 61
Cdd:COG3024   2 TKVPCPICGKPVEWSPENPYRPFCSKRCKLIDLGRWLSEEYRIPGEPLDDDEEDPEE 58
YacG pfam03884
DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by ...
 7-54 1.70e-23

DNA gyrase inhibitor YacG; YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. YacG has been shown to bind zinc and contains the structural motifs typical of zinc-binding proteins. The conserved four cysteine motif in this protein (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.


Pssm-ID: 427566  Cd Length: 48  Bit Score: 83.08  E-value: 1.70e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 556425477   7 VSCPTCGKTVVWGEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLS 54
Cdd:pfam03884  1 VRCPTCGKPVEWSPENPFRPFCSERCKLIDLGAWADEEYRIPGEPPPD 48
PRK01343 PRK01343
zinc-binding protein; Provisional
 9-58 1.99e-05

zinc-binding protein; Provisional


Pssm-ID: 234943  Cd Length: 57  Bit Score: 37.38  E-value: 1.99e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 556425477  9 CPTCGKTvvwgEVSPFRPFCCKRCQLIDLGEWAAEEKRIPSEGDLSDSDD 58
Cdd:PRK01343 12 CPECGKP----STREAYPFCSERCRDIDLNRWLSGSYVIPGAPDEEDDEE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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