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Conserved domains on  [gi|556425466|ref|WP_023310393|]
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MULTISPECIES: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [Enterobacter]

Protein Classification

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase( domain architecture ID 11484936)

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

EC:  6.3.2.10
Gene Symbol:  murF
Gene Ontology:  GO:0005524|GO:0009252|GO:0047480
SCOP:  4000234

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
1-452 0e+00

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


:

Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 888.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   1 MISITLSQAAAILQGDLYGQDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:PRK10773   1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:PRK10773  81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNAANS-DFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFP 319
Cdd:PRK10773 241 PNAANSvDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 320 IQLSENKLLLDDSYNANVGSMTAAVQVLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISH 399
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISE 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556425466 400 ASGVGEHFADKSALIARLKALITEKQIVTVLVKGSRSAAMEEVVHALQENGTC 452
Cdd:PRK10773 401 ASGVGEHFADKTALIARLKALLAEHQVITILVKGSRSAAMEEVVRALQENGTC 453
 
Name Accession Description Interval E-value
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
1-452 0e+00

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 888.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   1 MISITLSQAAAILQGDLYGQDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:PRK10773   1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:PRK10773  81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNAANS-DFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFP 319
Cdd:PRK10773 241 PNAANSvDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 320 IQLSENKLLLDDSYNANVGSMTAAVQVLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISH 399
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISE 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556425466 400 ASGVGEHFADKSALIARLKALITEKQIVTVLVKGSRSAAMEEVVHALQENGTC 452
Cdd:PRK10773 401 ASGVGEHFADKTALIARLKALLAEHQVITILVKGSRSAAMEEVVRALQENGTC 453
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
2-451 0e+00

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 585.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   2 ISITLSQAAAILQGDLYGQ-DLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:COG0770    1 ILLTLAEIAEATGGRLIGDpDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:COG0770   81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRkTWRFS 240
Cdd:COG0770  161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNaANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPI 320
Cdd:COG0770  240 LS-EDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVI 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 321 QLSENKLLLDDSYNANVGSMTAAVQVLSEMP--GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAIS 398
Cdd:COG0770  319 EGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIA 398
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 556425466 399 HASGV--GEHFADKSALIARLKALITEKqiVTVLVKGSRSAAMEEVVHALQENGT 451
Cdd:COG0770  399 EAAGGerAEHFEDKEELLAALKALLRPG--DVVLVKGSRGMGLERVVEALKEGAA 451
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
29-446 7.81e-162

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 462.89  E-value: 7.81e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   29 TDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDID--LPQIVVKDTRLAFGELAAWVRQQVPTRVVALT 106
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  107 GSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELGANHQGEIAWTVSLTRPEAALVNNLAA 186
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  187 AHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFSPNaaNSDFTATNIHVTSHG-TEFTLT 265
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGsTSFTLV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  266 TPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFpIQLSENKLLLDDSYNANVGSMTAAVQ 345
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  346 VLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISHASGV-GEHFADKSALIARLKALITEK 424
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKqGKHFADKDELLAFLKTLVRKG 397
                         410       420
                  ....*....|....*....|..
gi 556425466  425 qiVTVLVKGSRSAAMEEVVHAL 446
Cdd:TIGR01143 398 --DVVLVKGSRSVKLEKVVEAL 417
Mur_ligase_M pfam08245
Mur ligase middle domain;
106-283 1.03e-44

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 154.77  E-value: 1.03e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  106 TGSSGKTSVKEMTAAILSQCGNTLYTAG--------NLNNDIGVPMTLLRLTK-EHEFAVIELGANHQGEiAWTVSLTRP 176
Cdd:pfam08245   2 TGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLKP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  177 EAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSR--KTWRFSPNaANSDFTATNIH 254
Cdd:pfam08245  81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvRVITYGIE-GEADLRAANIE 159
                         170       180       190
                  ....*....|....*....|....*....|
gi 556425466  255 VTSHGTEFTL-TTPTGGIDVLLPLPGRHNI 283
Cdd:pfam08245 160 LSSDGTSFDLfTVPGGELEIEIPLLGRHNV 189
 
Name Accession Description Interval E-value
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
1-452 0e+00

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 888.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   1 MISITLSQAAAILQGDLYGQDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:PRK10773   1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:PRK10773  81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNAANS-DFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFP 319
Cdd:PRK10773 241 PNAANSvDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 320 IQLSENKLLLDDSYNANVGSMTAAVQVLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISH 399
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISE 400
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556425466 400 ASGVGEHFADKSALIARLKALITEKQIVTVLVKGSRSAAMEEVVHALQENGTC 452
Cdd:PRK10773 401 ASGVGEHFADKTALIARLKALLAEHQVITILVKGSRSAAMEEVVRALQENGTC 453
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
2-451 0e+00

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 585.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   2 ISITLSQAAAILQGDLYGQ-DLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:COG0770    1 ILLTLAEIAEATGGRLIGDpDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:COG0770   81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRkTWRFS 240
Cdd:COG0770  161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNaANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPI 320
Cdd:COG0770  240 LS-EDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVI 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 321 QLSENKLLLDDSYNANVGSMTAAVQVLSEMP--GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAIS 398
Cdd:COG0770  319 EGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIA 398
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 556425466 399 HASGV--GEHFADKSALIARLKALITEKqiVTVLVKGSRSAAMEEVVHALQENGT 451
Cdd:COG0770  399 EAAGGerAEHFEDKEELLAALKALLRPG--DVVLVKGSRGMGLERVVEALKEGAA 451
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
29-446 7.81e-162

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 462.89  E-value: 7.81e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   29 TDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDID--LPQIVVKDTRLAFGELAAWVRQQVPTRVVALT 106
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  107 GSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELGANHQGEIAWTVSLTRPEAALVNNLAA 186
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  187 AHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFSPNaaNSDFTATNIHVTSHG-TEFTLT 265
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGsTSFTLV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  266 TPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFpIQLSENKLLLDDSYNANVGSMTAAVQ 345
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  346 VLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISHASGV-GEHFADKSALIARLKALITEK 424
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKqGKHFADKDELLAFLKTLVRKG 397
                         410       420
                  ....*....|....*....|..
gi 556425466  425 qiVTVLVKGSRSAAMEEVVHAL 446
Cdd:TIGR01143 398 --DVVLVKGSRSVKLEKVVEAL 417
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
3-447 7.26e-137

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 416.80  E-value: 7.26e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   3 SITLSQAAAILQGDLYGQDLT---IDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR-RLDIDLPQI 78
Cdd:PRK11929 502 SSTLIKLRAAKGGSNSLQINSlphAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERqVADVDLPQI 581
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  79 VVKDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQ---CGNTLYTAGNLNNDIGVPMTLLRLTKEHEFA 155
Cdd:PRK11929 582 VVDDTRAALGRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAA 661
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 156 VIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRK 235
Cdd:PRK11929 662 VFELGMNHPGEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARR 741
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 236 TWRF----SPNAANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLK 311
Cdd:PRK11929 742 VLRFglqpGADVYAEKIAKDISVGEAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQ 821
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 312 AVPGRLFPIQLSENKLLLDDSYNANVGSMTAAVQVLSEMP-GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSA 390
Cdd:PRK11929 822 PVAGRMQRRRLSCGTRIIDDTYNANPDSMRAAIDVLAELPnGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITL 901
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 556425466 391 GKLSQAISHASGVG--EHFADKSALIARLKALITEKQIvtVLVKGSRSAAMEEVVHALQ 447
Cdd:PRK11929 902 GEAARDAAAAFGAGarGVCASVDEIIAALRGALPEGDS--VLIKGSRFMRLERVVDALS 958
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
24-449 5.54e-68

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 224.27  E-value: 5.54e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  24 IDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR----RLDIDLPQIVVKDTRLAFGELAAWVRQQVP 99
Cdd:PRK14093  28 VTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERaqrdKFAADAPLLVVDDVLAALRDLGRAARARLE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 100 TRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELGANHQGEIAWTVSLTRPEAA 179
Cdd:PRK14093 108 AKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 180 LVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFSPNAANSDFTATNIHVTSHG 259
Cdd:PRK14093 188 IITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAGIARIVSFGADEKADARLLDVALHA 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 260 TEFTLTTPTGGIDVL--LPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPIQL---SENKLLLDDSYN 334
Cdd:PRK14093 268 DCSAVHADILGHDVTykLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRGVRHTLevgGGEATLIDESYN 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 335 ANVGSMTAAVQVLSEMP----GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISHA--SGV-GEHF 407
Cdd:PRK14093 348 ANPASMAAALGVLGRAPvgpqGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVFCCGPLMRNLWDAlsSGKrGGYA 427
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 556425466 408 ADKSALIARLKALITEKQivTVLVKGSRSAAMEEVVHALQEN 449
Cdd:PRK14093 428 EDAAALESQVVAAIRAGD--VIMVKGSLGSRMKTIVTALEKR 467
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
2-448 1.84e-51

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 185.93  E-value: 1.84e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   2 ISITLSQAAAILQGDLYGQ-DLTIDAVTTDTRKIT--AGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLD----ID 74
Cdd:PRK11930   1 MSYTLESISGILGAEGLGDkDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHpeesYP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  75 LPQ-IVVKDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHE 153
Cdd:PRK11930  81 DANfLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 154 FAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTglpDDGIAILNADNNDWLN-WQSIIG 232
Cdd:PRK11930 161 LGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFK---DCDVIIYNGDNELISScITKSNL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 233 SRKTWRFSPNAANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKA 312
Cdd:PRK11930 238 TLKLISWSRKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEP 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 313 VPGRLFPIQLSENKLLLDDSYNANVGSMTAAVQVLS--EMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSA 390
Cdd:PRK11930 318 VAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNrrSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGI 397
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 391 GK--LSQAISHASGVGEHFADKSALIARLKALITEKQivTVLVKGSRSAAMEEVVHALQE 448
Cdd:PRK11930 398 GEeiSSEASKFEGTEKEFFKTTEAFLKSFAFLKFRNE--LILVKGARKFEFEQITELLEQ 455
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
27-317 1.84e-47

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 169.49  E-value: 1.84e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  27 VTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR---RLDIDLPQIVVKDTRLAFGELAAWVRQQvPTR-- 101
Cdd:COG0769    2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEApgaLLAAGVPVIVVPDPRAALALLAAAFYGH-PSQkl 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 102 -VVALTGSSGKTSVKEMTAAILSQCGntlYTAGN---LNNDIG-----VPMT---------LLRLTKEH--EFAVIE--- 158
Cdd:COG0769   81 kLIGVTGTNGKTTTTYLLAQILRALG---KKTGLigtVGNGIGgelipSSLTtpealdlqrLLAEMVDAgvTHVVMEvss 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 159 --LganHQG-------EIA-WTvSLTRPeaalvnnlaaaHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQ 228
Cdd:COG0769  158 haL---DQGrvdgvrfDVAvFT-NLTRD-----------HLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLA 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 229 SIIGSRkTWRFSPNaANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLA 308
Cdd:COG0769  223 AAAPAR-VITYGLK-ADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALE 300

                 ....*....
gi 556425466 309 NLKAVPGRL 317
Cdd:COG0769  301 KLKGVPGRM 309
Mur_ligase_M pfam08245
Mur ligase middle domain;
106-283 1.03e-44

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 154.77  E-value: 1.03e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  106 TGSSGKTSVKEMTAAILSQCGNTLYTAG--------NLNNDIGVPMTLLRLTK-EHEFAVIELGANHQGEiAWTVSLTRP 176
Cdd:pfam08245   2 TGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLKP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  177 EAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSR--KTWRFSPNaANSDFTATNIH 254
Cdd:pfam08245  81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvRVITYGIE-GEADLRAANIE 159
                         170       180       190
                  ....*....|....*....|....*....|
gi 556425466  255 VTSHGTEFTL-TTPTGGIDVLLPLPGRHNI 283
Cdd:pfam08245 160 LSSDGTSFDLfTVPGGELEIEIPLLGRHNV 189
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
20-317 1.88e-35

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 136.80  E-value: 1.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  20 QDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDI--DLPQIVVKDTRLAFGELAAWV--R 95
Cdd:PRK00139  11 APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAgtGVPVIIVPDLRKALALLAAAFygH 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  96 QQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTlyTA--GNLNNDIG-----------VPMTLLRLTKE-----HEFAVI 157
Cdd:PRK00139  91 PSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEK--TAliGTLGNGIGgelipsglttpDALDLQRLLAElvdagVTYAAM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 158 E-----LganHQGEIAWTV-------SLTRpeaalvnnlaaAHLEGFGSLEGVAKAKGEIYTGLpdDGIAILNADNNdwl 225
Cdd:PRK00139 169 EvsshaL---DQGRVDGLKfdvavftNLSR-----------DHLDYHGTMEDYLAAKARLFSEL--GLAAVINADDE--- 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 226 NWQSIIGSRKTWRFSPNAAnsDFTATNIHVTSHGTEFTLTTptggiDVLLPLPGRHNIANALAAAALSTAVGASHEAIKT 305
Cdd:PRK00139 230 VGRRLLALPDAYAVSMAGA--DLRATDVEYTDSGQTFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLEDALA 302
                        330
                 ....*....|..
gi 556425466 306 GLANLKAVPGRL 317
Cdd:PRK00139 303 ALAKLQGVPGRM 314
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
21-358 2.36e-33

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 130.90  E-value: 2.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   21 DLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDL---PQIVVKDTRLAFGELAAWVRQQ 97
Cdd:TIGR01085   1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVapvPVIIVPDLRHALSSLAAAFYGH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   98 vPTR---VVALTGSSGKTSVKEMTAAILSQCG------NTLYTAGNLNNDIGVP--------MTLLRLTKEH-----EFA 155
Cdd:TIGR01085  81 -PSKklkVIGVTGTNGKTTTTSLIAQLLRLLGkktgliGTIGYRLGGNDLIKNPaalttpeaLTLQSTLAEMveagaQYA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  156 VIELgANH---QGEIA--------WTvSLTRpeaalvnnlaaAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNAD---N 221
Cdd:TIGR01085 160 VMEV-SSHalaQGRVRgvrfdaavFT-NLSR-----------DHLDFHGTMENYFAAKASLFTELGLKRFAVINLDdeyG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  222 NDWLN------WQSIIGSRKTWRfspnaaNSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIA-NALAAAALST 294
Cdd:TIGR01085 227 AQFVKrlpkdiTVSAITQPADGR------AQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYnLLAALATLLH 300
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556425466  295 AVGASHEAIKTGLANLKAVPGRLFPIQLSENKLLLDDsYNANVGSMTAAVQVLSEMPGYRIMVV 358
Cdd:TIGR01085 301 LGGIDLEDIVAALEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVV 363
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
8-317 3.95e-28

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 117.88  E-value: 3.95e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   8 QAAAILQGD--LYGQDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRR-----LDIDLPQIVV 80
Cdd:PRK11929  11 KLEELLQALawLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEgedqvAAADALVLPV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  81 KDTRLAFGELAA--WVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNN-----DIGVPMTLLRLTKEHE 153
Cdd:PRK11929  91 ADLRKALGELAArwYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGArldgrLIPGSLTTPDAIILHR 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 154 -----------FAVIElgANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNN 222
Cdd:PRK11929 171 ilarmraagadAVAME--ASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDP 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 223 DWLNWQSIIGSRKTWRFSPNAANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEA 302
Cdd:PRK11929 249 AAARLLAALPRGLKVGYSPQNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQ 328
                        330
                 ....*....|....*
gi 556425466 303 IKTGLANLKAVPGRL 317
Cdd:PRK11929 329 IARALAAVSPVPGRM 343
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
89-451 8.57e-18

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 85.08  E-value: 8.57e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   89 ELAAWVrqqVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPMTLLRLTKEHEFAVIELgANHQgeIA 168
Cdd:TIGR01087  94 ELFLRL---VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLEL-SSFQ--LE 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  169 WTVSLtRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWrfspnaansdF 248
Cdd:TIGR01087 164 TTESL-RPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIW----------F 232
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  249 TATNIHvtshgtEFTLTTPTGGI-----DVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPIQLS 323
Cdd:TIGR01087 233 SVEKDA------ERGLCIRDGGLylkpnDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQK 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  324 ENKLLLDDSYNANVGsmtAAVQVLSEMPGYRIMVVGdmaelGDeseachtqvgeaAKAAGLDCVLSAgkLSQAISHASGV 403
Cdd:TIGR01087 307 NGVHFYNDSKATNVH---ATLAALSAFDNPVILIVG-----GD------------DKGADFSPLAPA--AAGKVKAVLAI 364
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 556425466  404 GEhfaDKSALIARLKALITEKQIVTVLvkgsrSAAMEEVVHALQENGT 451
Cdd:TIGR01087 365 GE---DAAKIAPLLKEAGLSVYLVESL-----EEAVQAAREVASPGDV 404
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
89-317 1.43e-15

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 78.58  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  89 ELAAWVrqqVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPM-TLLRLTKEHEFAVIELGAnHQgeI 167
Cdd:COG0771   97 ELAYRL---SPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGN----IGTPLlDLLLEPEPPDVYVLELSS-FQ--L 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 168 AWTVSLT---------RPEaalvnnlaaaHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWr 238
Cdd:COG0771  167 ETTPSLRpdvavilniTPD----------HLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVP- 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 239 FSPN-AANSDFTATN--IHVTSHGTEFtlttptggIDV-LLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVP 314
Cdd:COG0771  236 FSLKePLEGGAGLEDgkLVDRASGEEL--------LPVdDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLP 307

                 ...
gi 556425466 315 GRL 317
Cdd:COG0771  308 HRL 310
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
12-368 2.47e-13

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 71.61  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  12 ILQGDLYG---QDLTIDAVTTDTRKITAGCLFVAlKGERFdAHDFAEQAKENGAGALLVSRRLDIDLPQIVVKDTRLAFG 88
Cdd:PRK14022  19 IIDQDHYHynySGVQFDDISYDSRTADEGTLFFA-KGAYF-KHKFLQNAITQGLKLYVSEKDYEVGIPQVIVPDIKKAMS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  89 ELAAWVRQ--QVPTRVVALTGSSGKTSVKEMTAAILSQCG-NTLY--TAGNLNND------IGVPMTlLRLTKEHEFAVi 157
Cdd:PRK14022  97 LIAMEFYDnpQHKLKLLAFTGTKGKTTAAYFAYHILKQLHkPAMLstMNTTLDGEtffksaLTTPES-LDLFKMMAEAV- 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 158 ELGANHqgeIAWTVSltrpeaalvnnlaaAHLEGFGSLEGVAKAKGeIYTGLPDDGI----------------------- 214
Cdd:PRK14022 175 DNGMTH---LIMEVS--------------SQAYLVGRVYGLTFDVG-VFLNITPDHIgpiehptfedyfyhkrllmensk 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 215 -AILNADNNDWLNWQSIIGSRKTWRFSPNAANsDFTATNihvtshgtEFTLTT---PTGGIDVllPLPGRHNIANALAAA 290
Cdd:PRK14022 237 aVVVNSDMDHFSELLEQVTPQEHDFYGIDSEN-QIMASN--------AFSFEAtgkLAGTYDI--QLIGKFNQENAMAAG 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 291 ALSTAVGASHEAIKTGLANlKAVPGRL------FPIqlsenKLLLDDSYNANvgSMTAAVQVLSEMPGYRIMVVGDMAEL 364
Cdd:PRK14022 306 LACLRLGASLEDIQKGIAQ-TPVPGRMevltqsNGA-----KVFIDYAHNGD--SLNKLIDVVEEHQKGKLILLLGAAGN 377

                 ....
gi 556425466 365 GDES 368
Cdd:PRK14022 378 KGES 381
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
23-92 3.91e-12

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 61.87  E-value: 3.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   23 TIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR-----RLDI------DLPQIVVKDTRLAFGELA 91
Cdd:pfam01225   1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDaanniSPDNpeleaaKVPGIPVIDRREALAELA 80

                  .
gi 556425466   92 A 92
Cdd:pfam01225  81 A 81
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
313-388 4.50e-11

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 58.89  E-value: 4.50e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556425466  313 VPGRLFPIQLSENKLLLDDsYNANVGSMTAAVQVLSEMPGYRIMVV-GDMaelGDESEACHTQVGEAAKAAGLDCVL 388
Cdd:pfam02875   1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPGRLILVfGGM---GDRDAEFHALLGRLAAALADVVIL 73
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
101-358 1.31e-09

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 60.01  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  101 RVVALTGSSGKTSVKEMTAAILSQCG-NTLYTAGNLNNDIGvpmTLLRLTKEhEFAVIELG------ANHQGEIAwTVSL 173
Cdd:TIGR01082 100 HSIAVAGTHGKTTTTAMIAVILKEAGlDPTVVVGGLVKEAG---TNARLGSG-EYLVAEADesdasfLHLQPNVA-IVTN 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  174 TRPEaalvnnlaaaHLEGFG-SLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIgSRKTWRFSPNAANSDFTATN 252
Cdd:TIGR01082 175 IEPD----------HLDTYGsSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKA-TEQVITYGGSGEDADYRAEN 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  253 IHVTSHGTEFTLTTP-TGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVpGRLFPIQLSENKLLLDD 331
Cdd:TIGR01082 244 IQQSGAEGKFSVRGKgKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGV-KRRFEILGEFGGVLLID 322
                         250       260
                  ....*....|....*....|....*...
gi 556425466  332 SYNANVGSMTAAVQVLSEM-PGYRIMVV 358
Cdd:TIGR01082 323 DYAHHPTEIKATLKAARQGyPDKRIVVV 350
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
89-317 1.12e-08

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 56.90  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  89 ELAAWVrqqVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPM--TLLRLTKEhEFAVIELgANHQGE 166
Cdd:PRK14106 100 ELAYRF---SKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGED-DIIVAEV-SSFQLE 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 167 iawTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNdwlnwqsiigsrKTWRFSPNAANS 246
Cdd:PRK14106 171 ---TIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDP------------RTRSLAKKAKAR 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 247 DFTATNIHVTSHGT----EFTLTTPTGGIDVL-----LPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRL 317
Cdd:PRK14106 236 VIFFSRKSLLEEGVfvknGKIVISLGGKEEEVidideIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRI 315
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
90-313 1.51e-08

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 56.61  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466  90 LAAWVRQQvptRVVALTGSSGKTSVKEMTAAILSQCG-NTLYTAGNLNNDIGVPMtllRLTKEhEFAVIE----LGA--N 162
Cdd:COG0773   97 LAELMRGK---RSIAVAGTHGKTTTTSMLAHILEEAGlDPTFLIGGILNNFGTNA---RLGDG-DYFVAEadesDGSflH 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 163 HQGEIAwtVsLT--RPEaalvnnlaaaHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNdwlNWQSIIG--SRKTWR 238
Cdd:COG0773  170 YSPDIA--V-VTniEAD----------HLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDP---GLRELLPrcGRPVIT 233
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556425466 239 FSPNAaNSDFTATNIHVTSHGTEFTLTTPTGGI-DVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAV 313
Cdd:COG0773  234 YGFSE-DADYRAENIRIDGGGSTFDVLRRGEELgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGV 308
LpxD COG1044
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ...
3-93 4.72e-05

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 440666 [Multi-domain]  Cd Length: 335  Bit Score: 45.39  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   3 SITLSQAAAILQGDLYGQ-DLTIDAVTTdTRKITAGCL-FVAlkGERFdahdfAEQAKENGAGALLVSRRLDIDLPQ--- 77
Cdd:COG1044    1 SFTLAELAELLGGELVGDgDLEITGVAP-LEEAGPGDLsFLA--NPKY-----AKQLATTKASAVIVPPDFAAALPGlal 72
                         90
                 ....*....|....*.
gi 556425466  78 IVVKDTRLAFGELAAW 93
Cdd:COG1044   73 IVVDNPYLAFAKLLQL 88
LpxD pfam04613
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; UDP-3-O-[3-hydroxymyristoyl] ...
53-93 3.58e-03

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyzes an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]. Members of this family also contain a hexapeptide repeat (pfam00132). This family constitutes the non-repeating region of LPXD proteins.


Pssm-ID: 461366 [Multi-domain]  Cd Length: 69  Bit Score: 35.94  E-value: 3.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 556425466   53 FAEQAKENGAGALLVSRRLDIDLPQ----IVVKDTRLAFGELAAW 93
Cdd:pfam04613  25 YAKYLATTKASAVIVPPDFAPQAPAtatlLVVDNPYLAFAKLLQL 69
lpxD PRK00892
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional
3-93 7.02e-03

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional


Pssm-ID: 234858 [Multi-domain]  Cd Length: 343  Bit Score: 38.58  E-value: 7.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466   3 SITLSQAAAILQGDLYG-QDLTIDAVTTDTRKiTAGCL-FVAlkGERFdahdfAEQAKENGAGALLVSRRLDIDLPQ--- 77
Cdd:PRK00892   2 SLTLAELAELLGAELVGdGDIEITGVASLEEA-GPGQIsFLA--NPKY-----RKQLATTKAGAVIVSPDDAEFVPAgna 73
                         90
                 ....*....|....*..
gi 556425466  78 -IVVKDTRLAFGELAAW 93
Cdd:PRK00892  74 lLVVKNPYLAFARLAQL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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