|
Name |
Accession |
Description |
Interval |
E-value |
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-452 |
0e+00 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 888.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 1 MISITLSQAAAILQGDLYGQDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:PRK10773 81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNAANS-DFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFP 319
Cdd:PRK10773 241 PNAANSvDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 320 IQLSENKLLLDDSYNANVGSMTAAVQVLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISH 399
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISE 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 556425466 400 ASGVGEHFADKSALIARLKALITEKQIVTVLVKGSRSAAMEEVVHALQENGTC 452
Cdd:PRK10773 401 ASGVGEHFADKTALIARLKALLAEHQVITILVKGSRSAAMEEVVRALQENGTC 453
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-451 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 585.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 2 ISITLSQAAAILQGDLYGQ-DLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDLPQIVV 80
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGDpDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 81 KDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELG 160
Cdd:COG0770 81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 161 ANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRkTWRFS 240
Cdd:COG0770 161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 241 PNaANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPI 320
Cdd:COG0770 240 LS-EDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 321 QLSENKLLLDDSYNANVGSMTAAVQVLSEMP--GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAIS 398
Cdd:COG0770 319 EGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIA 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 556425466 399 HASGV--GEHFADKSALIARLKALITEKqiVTVLVKGSRSAAMEEVVHALQENGT 451
Cdd:COG0770 399 EAAGGerAEHFEDKEELLAALKALLRPG--DVVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
29-446 |
7.81e-162 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 462.89 E-value: 7.81e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 29 TDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDID--LPQIVVKDTRLAFGELAAWVRQQVPTRVVALT 106
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 107 GSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELGANHQGEIAWTVSLTRPEAALVNNLAA 186
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 187 AHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFSPNaaNSDFTATNIHVTSHG-TEFTLT 265
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGsTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 266 TPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFpIQLSENKLLLDDSYNANVGSMTAAVQ 345
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 346 VLSEMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISHASGV-GEHFADKSALIARLKALITEK 424
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKqGKHFADKDELLAFLKTLVRKG 397
|
410 420
....*....|....*....|..
gi 556425466 425 qiVTVLVKGSRSAAMEEVVHAL 446
Cdd:TIGR01143 398 --DVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
3-447 |
7.26e-137 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 416.80 E-value: 7.26e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 3 SITLSQAAAILQGDLYGQDLT---IDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR-RLDIDLPQI 78
Cdd:PRK11929 502 SSTLIKLRAAKGGSNSLQINSlphAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERqVADVDLPQI 581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 79 VVKDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQ---CGNTLYTAGNLNNDIGVPMTLLRLTKEHEFA 155
Cdd:PRK11929 582 VVDDTRAALGRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAA 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 156 VIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRK 235
Cdd:PRK11929 662 VFELGMNHPGEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARR 741
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 236 TWRF----SPNAANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLK 311
Cdd:PRK11929 742 VLRFglqpGADVYAEKIAKDISVGEAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQ 821
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 312 AVPGRLFPIQLSENKLLLDDSYNANVGSMTAAVQVLSEMP-GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSA 390
Cdd:PRK11929 822 PVAGRMQRRRLSCGTRIIDDTYNANPDSMRAAIDVLAELPnGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITL 901
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 556425466 391 GKLSQAISHASGVG--EHFADKSALIARLKALITEKQIvtVLVKGSRSAAMEEVVHALQ 447
Cdd:PRK11929 902 GEAARDAAAAFGAGarGVCASVDEIIAALRGALPEGDS--VLIKGSRFMRLERVVDALS 958
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
24-449 |
5.54e-68 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 224.27 E-value: 5.54e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 24 IDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR----RLDIDLPQIVVKDTRLAFGELAAWVRQQVP 99
Cdd:PRK14093 28 VTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERaqrdKFAADAPLLVVDDVLAALRDLGRAARARLE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 100 TRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHEFAVIELGANHQGEIAWTVSLTRPEAA 179
Cdd:PRK14093 108 AKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 180 LVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWRFSPNAANSDFTATNIHVTSHG 259
Cdd:PRK14093 188 IITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAGIARIVSFGADEKADARLLDVALHA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 260 TEFTLTTPTGGIDVL--LPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPIQL---SENKLLLDDSYN 334
Cdd:PRK14093 268 DCSAVHADILGHDVTykLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRGVRHTLevgGGEATLIDESYN 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 335 ANVGSMTAAVQVLSEMP----GYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSAGKLSQAISHA--SGV-GEHF 407
Cdd:PRK14093 348 ANPASMAAALGVLGRAPvgpqGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVFCCGPLMRNLWDAlsSGKrGGYA 427
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 556425466 408 ADKSALIARLKALITEKQivTVLVKGSRSAAMEEVVHALQEN 449
Cdd:PRK14093 428 EDAAALESQVVAAIRAGD--VIMVKGSLGSRMKTIVTALEKR 467
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
2-448 |
1.84e-51 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 185.93 E-value: 1.84e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 2 ISITLSQAAAILQGDLYGQ-DLTIDAVTTDTRKIT--AGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLD----ID 74
Cdd:PRK11930 1 MSYTLESISGILGAEGLGDkDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHpeesYP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 75 LPQ-IVVKDTRLAFGELAAWVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTKEHE 153
Cdd:PRK11930 81 DANfLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 154 FAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTglpDDGIAILNADNNDWLN-WQSIIG 232
Cdd:PRK11930 161 LGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFK---DCDVIIYNGDNELISScITKSNL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 233 SRKTWRFSPNAANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKA 312
Cdd:PRK11930 238 TLKLISWSRKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 313 VPGRLFPIQLSENKLLLDDSYNANVGSMTAAVQVLS--EMPGYRIMVVGDMAELGDESEACHTQVGEAAKAAGLDCVLSA 390
Cdd:PRK11930 318 VAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNrrSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGI 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 391 GK--LSQAISHASGVGEHFADKSALIARLKALITEKQivTVLVKGSRSAAMEEVVHALQE 448
Cdd:PRK11930 398 GEeiSSEASKFEGTEKEFFKTTEAFLKSFAFLKFRNE--LILVKGARKFEFEQITELLEQ 455
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
27-317 |
1.84e-47 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 169.49 E-value: 1.84e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 27 VTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR---RLDIDLPQIVVKDTRLAFGELAAWVRQQvPTR-- 101
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEApgaLLAAGVPVIVVPDPRAALALLAAAFYGH-PSQkl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 102 -VVALTGSSGKTSVKEMTAAILSQCGntlYTAGN---LNNDIG-----VPMT---------LLRLTKEH--EFAVIE--- 158
Cdd:COG0769 81 kLIGVTGTNGKTTTTYLLAQILRALG---KKTGLigtVGNGIGgelipSSLTtpealdlqrLLAEMVDAgvTHVVMEvss 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 159 --LganHQG-------EIA-WTvSLTRPeaalvnnlaaaHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQ 228
Cdd:COG0769 158 haL---DQGrvdgvrfDVAvFT-NLTRD-----------HLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 229 SIIGSRkTWRFSPNaANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLA 308
Cdd:COG0769 223 AAAPAR-VITYGLK-ADADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALE 300
|
....*....
gi 556425466 309 NLKAVPGRL 317
Cdd:COG0769 301 KLKGVPGRM 309
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
106-283 |
1.03e-44 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 154.77 E-value: 1.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 106 TGSSGKTSVKEMTAAILSQCGNTLYTAG--------NLNNDIGVPMTLLRLTK-EHEFAVIELGANHQGEiAWTVSLTRP 176
Cdd:pfam08245 2 TGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 177 EAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSR--KTWRFSPNaANSDFTATNIH 254
Cdd:pfam08245 81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvRVITYGIE-GEADLRAANIE 159
|
170 180 190
....*....|....*....|....*....|
gi 556425466 255 VTSHGTEFTL-TTPTGGIDVLLPLPGRHNI 283
Cdd:pfam08245 160 LSSDGTSFDLfTVPGGELEIEIPLLGRHNV 189
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
20-317 |
1.88e-35 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 136.80 E-value: 1.88e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 20 QDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDI--DLPQIVVKDTRLAFGELAAWV--R 95
Cdd:PRK00139 11 APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEAgtGVPVIIVPDLRKALALLAAAFygH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 96 QQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTlyTA--GNLNNDIG-----------VPMTLLRLTKE-----HEFAVI 157
Cdd:PRK00139 91 PSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEK--TAliGTLGNGIGgelipsglttpDALDLQRLLAElvdagVTYAAM 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 158 E-----LganHQGEIAWTV-------SLTRpeaalvnnlaaAHLEGFGSLEGVAKAKGEIYTGLpdDGIAILNADNNdwl 225
Cdd:PRK00139 169 EvsshaL---DQGRVDGLKfdvavftNLSR-----------DHLDYHGTMEDYLAAKARLFSEL--GLAAVINADDE--- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 226 NWQSIIGSRKTWRFSPNAAnsDFTATNIHVTSHGTEFTLTTptggiDVLLPLPGRHNIANALAAAALSTAVGASHEAIKT 305
Cdd:PRK00139 230 VGRRLLALPDAYAVSMAGA--DLRATDVEYTDSGQTFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLEDALA 302
|
330
....*....|..
gi 556425466 306 GLANLKAVPGRL 317
Cdd:PRK00139 303 ALAKLQGVPGRM 314
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
21-358 |
2.36e-33 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 130.90 E-value: 2.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 21 DLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRRLDIDL---PQIVVKDTRLAFGELAAWVRQQ 97
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVapvPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 98 vPTR---VVALTGSSGKTSVKEMTAAILSQCG------NTLYTAGNLNNDIGVP--------MTLLRLTKEH-----EFA 155
Cdd:TIGR01085 81 -PSKklkVIGVTGTNGKTTTTSLIAQLLRLLGkktgliGTIGYRLGGNDLIKNPaalttpeaLTLQSTLAEMveagaQYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 156 VIELgANH---QGEIA--------WTvSLTRpeaalvnnlaaAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNAD---N 221
Cdd:TIGR01085 160 VMEV-SSHalaQGRVRgvrfdaavFT-NLSR-----------DHLDFHGTMENYFAAKASLFTELGLKRFAVINLDdeyG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 222 NDWLN------WQSIIGSRKTWRfspnaaNSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIA-NALAAAALST 294
Cdd:TIGR01085 227 AQFVKrlpkdiTVSAITQPADGR------AQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNVYnLLAALATLLH 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556425466 295 AVGASHEAIKTGLANLKAVPGRLFPIQLSENKLLLDDsYNANVGSMTAAVQVLSEMPGYRIMVV 358
Cdd:TIGR01085 301 LGGIDLEDIVAALEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVV 363
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
8-317 |
3.95e-28 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 117.88 E-value: 3.95e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 8 QAAAILQGD--LYGQDLTIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSRR-----LDIDLPQIVV 80
Cdd:PRK11929 11 KLEELLQALawLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEgedqvAAADALVLPV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 81 KDTRLAFGELAA--WVRQQVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNN-----DIGVPMTLLRLTKEHE 153
Cdd:PRK11929 91 ADLRKALGELAArwYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGArldgrLIPGSLTTPDAIILHR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 154 -----------FAVIElgANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNN 222
Cdd:PRK11929 171 ilarmraagadAVAME--ASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 223 DWLNWQSIIGSRKTWRFSPNAANSDFTATNIHVTSHGTEFTLTTPTGGIDVLLPLPGRHNIANALAAAALSTAVGASHEA 302
Cdd:PRK11929 249 AAARLLAALPRGLKVGYSPQNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQ 328
|
330
....*....|....*
gi 556425466 303 IKTGLANLKAVPGRL 317
Cdd:PRK11929 329 IARALAAVSPVPGRM 343
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
89-451 |
8.57e-18 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 85.08 E-value: 8.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 89 ELAAWVrqqVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPMTLLRLTKEHEFAVIELgANHQgeIA 168
Cdd:TIGR01087 94 ELFLRL---VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLEL-SSFQ--LE 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 169 WTVSLtRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWrfspnaansdF 248
Cdd:TIGR01087 164 TTESL-RPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIW----------F 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 249 TATNIHvtshgtEFTLTTPTGGI-----DVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRLFPIQLS 323
Cdd:TIGR01087 233 SVEKDA------ERGLCIRDGGLylkpnDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQK 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 324 ENKLLLDDSYNANVGsmtAAVQVLSEMPGYRIMVVGdmaelGDeseachtqvgeaAKAAGLDCVLSAgkLSQAISHASGV 403
Cdd:TIGR01087 307 NGVHFYNDSKATNVH---ATLAALSAFDNPVILIVG-----GD------------DKGADFSPLAPA--AAGKVKAVLAI 364
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 556425466 404 GEhfaDKSALIARLKALITEKQIVTVLvkgsrSAAMEEVVHALQENGT 451
Cdd:TIGR01087 365 GE---DAAKIAPLLKEAGLSVYLVESL-----EEAVQAAREVASPGDV 404
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
89-317 |
1.43e-15 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 78.58 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 89 ELAAWVrqqVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPM-TLLRLTKEHEFAVIELGAnHQgeI 167
Cdd:COG0771 97 ELAYRL---SPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGN----IGTPLlDLLLEPEPPDVYVLELSS-FQ--L 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 168 AWTVSLT---------RPEaalvnnlaaaHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIGSRKTWr 238
Cdd:COG0771 167 ETTPSLRpdvavilniTPD----------HLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVP- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 239 FSPN-AANSDFTATN--IHVTSHGTEFtlttptggIDV-LLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVP 314
Cdd:COG0771 236 FSLKePLEGGAGLEDgkLVDRASGEEL--------LPVdDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLP 307
|
...
gi 556425466 315 GRL 317
Cdd:COG0771 308 HRL 310
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
12-368 |
2.47e-13 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 71.61 E-value: 2.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 12 ILQGDLYG---QDLTIDAVTTDTRKITAGCLFVAlKGERFdAHDFAEQAKENGAGALLVSRRLDIDLPQIVVKDTRLAFG 88
Cdd:PRK14022 19 IIDQDHYHynySGVQFDDISYDSRTADEGTLFFA-KGAYF-KHKFLQNAITQGLKLYVSEKDYEVGIPQVIVPDIKKAMS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 89 ELAAWVRQ--QVPTRVVALTGSSGKTSVKEMTAAILSQCG-NTLY--TAGNLNND------IGVPMTlLRLTKEHEFAVi 157
Cdd:PRK14022 97 LIAMEFYDnpQHKLKLLAFTGTKGKTTAAYFAYHILKQLHkPAMLstMNTTLDGEtffksaLTTPES-LDLFKMMAEAV- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 158 ELGANHqgeIAWTVSltrpeaalvnnlaaAHLEGFGSLEGVAKAKGeIYTGLPDDGI----------------------- 214
Cdd:PRK14022 175 DNGMTH---LIMEVS--------------SQAYLVGRVYGLTFDVG-VFLNITPDHIgpiehptfedyfyhkrllmensk 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 215 -AILNADNNDWLNWQSIIGSRKTWRFSPNAANsDFTATNihvtshgtEFTLTT---PTGGIDVllPLPGRHNIANALAAA 290
Cdd:PRK14022 237 aVVVNSDMDHFSELLEQVTPQEHDFYGIDSEN-QIMASN--------AFSFEAtgkLAGTYDI--QLIGKFNQENAMAAG 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 291 ALSTAVGASHEAIKTGLANlKAVPGRL------FPIqlsenKLLLDDSYNANvgSMTAAVQVLSEMPGYRIMVVGDMAEL 364
Cdd:PRK14022 306 LACLRLGASLEDIQKGIAQ-TPVPGRMevltqsNGA-----KVFIDYAHNGD--SLNKLIDVVEEHQKGKLILLLGAAGN 377
|
....
gi 556425466 365 GDES 368
Cdd:PRK14022 378 KGES 381
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
23-92 |
3.91e-12 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 61.87 E-value: 3.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 23 TIDAVTTDTRKITAGCLFVALKGERFDAHDFAEQAKENGAGALLVSR-----RLDI------DLPQIVVKDTRLAFGELA 91
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDaanniSPDNpeleaaKVPGIPVIDRREALAELA 80
|
.
gi 556425466 92 A 92
Cdd:pfam01225 81 A 81
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
313-388 |
4.50e-11 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 58.89 E-value: 4.50e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556425466 313 VPGRLFPIQLSENKLLLDDsYNANVGSMTAAVQVLSEMPGYRIMVV-GDMaelGDESEACHTQVGEAAKAAGLDCVL 388
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPGRLILVfGGM---GDRDAEFHALLGRLAAALADVVIL 73
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
101-358 |
1.31e-09 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 60.01 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 101 RVVALTGSSGKTSVKEMTAAILSQCG-NTLYTAGNLNNDIGvpmTLLRLTKEhEFAVIELG------ANHQGEIAwTVSL 173
Cdd:TIGR01082 100 HSIAVAGTHGKTTTTAMIAVILKEAGlDPTVVVGGLVKEAG---TNARLGSG-EYLVAEADesdasfLHLQPNVA-IVTN 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 174 TRPEaalvnnlaaaHLEGFG-SLEGVAKAKGEIYTGLPDDGIAILNADNNDWLNWQSIIgSRKTWRFSPNAANSDFTATN 252
Cdd:TIGR01082 175 IEPD----------HLDTYGsSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKA-TEQVITYGGSGEDADYRAEN 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 253 IHVTSHGTEFTLTTP-TGGIDVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVpGRLFPIQLSENKLLLDD 331
Cdd:TIGR01082 244 IQQSGAEGKFSVRGKgKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGV-KRRFEILGEFGGVLLID 322
|
250 260
....*....|....*....|....*...
gi 556425466 332 SYNANVGSMTAAVQVLSEM-PGYRIMVV 358
Cdd:TIGR01082 323 DYAHHPTEIKATLKAARQGyPDKRIVVV 350
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
89-317 |
1.12e-08 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 56.90 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 89 ELAAWVrqqVPTRVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNlnndIGVPM--TLLRLTKEhEFAVIELgANHQGE 166
Cdd:PRK14106 100 ELAYRF---SKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGED-DIIVAEV-SSFQLE 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 167 iawTVSLTRPEAALVNNLAAAHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNdwlnwqsiigsrKTWRFSPNAANS 246
Cdd:PRK14106 171 ---TIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDP------------RTRSLAKKAKAR 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 247 DFTATNIHVTSHGT----EFTLTTPTGGIDVL-----LPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAVPGRL 317
Cdd:PRK14106 236 VIFFSRKSLLEEGVfvknGKIVISLGGKEEEVidideIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRI 315
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
90-313 |
1.51e-08 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 56.61 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 90 LAAWVRQQvptRVVALTGSSGKTSVKEMTAAILSQCG-NTLYTAGNLNNDIGVPMtllRLTKEhEFAVIE----LGA--N 162
Cdd:COG0773 97 LAELMRGK---RSIAVAGTHGKTTTTSMLAHILEEAGlDPTFLIGGILNNFGTNA---RLGDG-DYFVAEadesDGSflH 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 163 HQGEIAwtVsLT--RPEaalvnnlaaaHLEGFGSLEGVAKAKGEIYTGLPDDGIAILNADNNdwlNWQSIIG--SRKTWR 238
Cdd:COG0773 170 YSPDIA--V-VTniEAD----------HLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDP---GLRELLPrcGRPVIT 233
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556425466 239 FSPNAaNSDFTATNIHVTSHGTEFTLTTPTGGI-DVLLPLPGRHNIANALAAAALSTAVGASHEAIKTGLANLKAV 313
Cdd:COG0773 234 YGFSE-DADYRAENIRIDGGGSTFDVLRRGEELgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGV 308
|
|
| LpxD |
COG1044 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ... |
3-93 |
4.72e-05 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 440666 [Multi-domain] Cd Length: 335 Bit Score: 45.39 E-value: 4.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 3 SITLSQAAAILQGDLYGQ-DLTIDAVTTdTRKITAGCL-FVAlkGERFdahdfAEQAKENGAGALLVSRRLDIDLPQ--- 77
Cdd:COG1044 1 SFTLAELAELLGGELVGDgDLEITGVAP-LEEAGPGDLsFLA--NPKY-----AKQLATTKASAVIVPPDFAAALPGlal 72
|
90
....*....|....*.
gi 556425466 78 IVVKDTRLAFGELAAW 93
Cdd:COG1044 73 IVVDNPYLAFAKLLQL 88
|
|
| LpxD |
pfam04613 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; UDP-3-O-[3-hydroxymyristoyl] ... |
53-93 |
3.58e-03 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyzes an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]. Members of this family also contain a hexapeptide repeat (pfam00132). This family constitutes the non-repeating region of LPXD proteins.
Pssm-ID: 461366 [Multi-domain] Cd Length: 69 Bit Score: 35.94 E-value: 3.58e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 556425466 53 FAEQAKENGAGALLVSRRLDIDLPQ----IVVKDTRLAFGELAAW 93
Cdd:pfam04613 25 YAKYLATTKASAVIVPPDFAPQAPAtatlLVVDNPYLAFAKLLQL 69
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| lpxD |
PRK00892 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional |
3-93 |
7.02e-03 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional
Pssm-ID: 234858 [Multi-domain] Cd Length: 343 Bit Score: 38.58 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425466 3 SITLSQAAAILQGDLYG-QDLTIDAVTTDTRKiTAGCL-FVAlkGERFdahdfAEQAKENGAGALLVSRRLDIDLPQ--- 77
Cdd:PRK00892 2 SLTLAELAELLGAELVGdGDIEITGVASLEEA-GPGQIsFLA--NPKY-----RKQLATTKAGAVIVSPDDAEFVPAgna 73
|
90
....*....|....*..
gi 556425466 78 -IVVKDTRLAFGELAAW 93
Cdd:PRK00892 74 lLVVKNPYLAFARLAQL 90
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