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Conserved domains on  [gi|556424903|ref|WP_023309830|]
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MULTISPECIES: type I toxin-antitoxin system toxin TisB [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TisB_tox super family cl37445
type I toxin-antitoxin system toxin TisB; Members of this family are the TisB toxin protein of ...
 1-29 5.32e-03

type I toxin-antitoxin system toxin TisB; Members of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics. [Cellular processes, Adaptations to atypical conditions]


The actual alignment was detected with superfamily member TIGR04459:

Pssm-ID: 275252  Cd Length: 29  Bit Score: 29.34  E-value: 5.32e-03
                         10        20
                 ....*....|....*....|....*....
gi 556424903   1 MSVVDMVILILKLIVAVLQLLDAVLKFLR 29
Cdd:TIGR04459  1 MGVVDIVILILKLIVAVLQLLDAVLKYLR 29
 
Name Accession Description Interval E-value
TisB_tox TIGR04459
type I toxin-antitoxin system toxin TisB; Members of this family are the TisB toxin protein of ...
 1-29 5.32e-03

type I toxin-antitoxin system toxin TisB; Members of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 275252  Cd Length: 29  Bit Score: 29.34  E-value: 5.32e-03
                         10        20
                 ....*....|....*....|....*....
gi 556424903   1 MSVVDMVILILKLIVAVLQLLDAVLKFLR 29
Cdd:TIGR04459  1 MGVVDIVILILKLIVAVLQLLDAVLKYLR 29
 
Name Accession Description Interval E-value
TisB_tox TIGR04459
type I toxin-antitoxin system toxin TisB; Members of this family are the TisB toxin protein of ...
 1-29 5.32e-03

type I toxin-antitoxin system toxin TisB; Members of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 275252  Cd Length: 29  Bit Score: 29.34  E-value: 5.32e-03
                         10        20
                 ....*....|....*....|....*....
gi 556424903   1 MSVVDMVILILKLIVAVLQLLDAVLKFLR 29
Cdd:TIGR04459  1 MGVVDIVILILKLIVAVLQLLDAVLKYLR 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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