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Conserved domains on  [gi|556356509|ref|WP_023300101|]
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MULTISPECIES: methyl-accepting chemotaxis protein [Enterobacter]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1000955)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 21-529 2.09e-73

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15048:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 553  Bit Score: 242.99  E-value: 2.09e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  21 LLTGIFCIIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEGSW 100
Cdd:PRK15048   7 VVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 101 HSLMDEAQKSLAASQQAWQAWLALNPPQD-----EGLVNSYQLFFGAISEQAEGLVKTNsIDLFFAVPAQAFQTDFNDNF 175
Cdd:PRK15048  87 VELLDSARKTLAQAATHYKKFKSMAPLPEmvatsRNIDEKYKNYYTALTELIDYLDYGN-TGAYFAQPTQGMQNAMGEAF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 176 ARYQQRSEKQAIQGRQSLMEQLSGLQRLFLFAPLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAAGDLSGIPpdVVRF 255
Cdd:PRK15048 166 AQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTL--TIDG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 256 NREISQLSGSITAMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKL 335
Cdd:PRK15048 244 RSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQ 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 336 ARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGL 415
Cdd:PRK15048 324 ASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRN 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 416 LARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTRQLQALNQVSR 495
Cdd:PRK15048 404 LASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQ 483

                        490       500       510
                 ....*....|....*....|....*....|....
gi 556356509 496 QTDVLVSEASNASERLHRESDLLLQAVSRFRLPA 529
Cdd:PRK15048 484 QNASLVQESAAAAAALEEQASRLTQAVSAFRLAA 517
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 21-529 2.09e-73

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 242.99  E-value: 2.09e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  21 LLTGIFCIIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEGSW 100
Cdd:PRK15048   7 VVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 101 HSLMDEAQKSLAASQQAWQAWLALNPPQD-----EGLVNSYQLFFGAISEQAEGLVKTNsIDLFFAVPAQAFQTDFNDNF 175
Cdd:PRK15048  87 VELLDSARKTLAQAATHYKKFKSMAPLPEmvatsRNIDEKYKNYYTALTELIDYLDYGN-TGAYFAQPTQGMQNAMGEAF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 176 ARYQQRSEKQAIQGRQSLMEQLSGLQRLFLFAPLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAAGDLSGIPpdVVRF 255
Cdd:PRK15048 166 AQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTL--TIDG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 256 NREISQLSGSITAMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKL 335
Cdd:PRK15048 244 RSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQ 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 336 ARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGL 415
Cdd:PRK15048 324 ASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRN 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 416 LARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTRQLQALNQVSR 495
Cdd:PRK15048 404 LASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQ 483

                        490       500       510
                 ....*....|....*....|....*....|....
gi 556356509 496 QTDVLVSEASNASERLHRESDLLLQAVSRFRLPA 529
Cdd:PRK15048 484 QNASLVQESAAAAAALEEQASRLTQAVSAFRLAA 517
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
28-527 1.83e-60

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 208.34  E-value: 1.83e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  28 IIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEGSWHSLMDEA 107
Cdd:COG0840   13 ALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 108 QKSLAASQQAWQAWLALNPPQDEGLVNSYQLFFGAISEQAEGLVKTNSIDLFFAVPAQAFQTDFNDNFARYQQRSEKQAI 187
Cdd:COG0840   93 LALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAAL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 188 QGRQSLMEQLSGLQRLflfapLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAAGDLSGIPPdvVRFNREISQLSGSIT 267
Cdd:COG0840  173 ALAAAALALALLAAAL-----LALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID--VDSKDEIGQLADAFN 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 268 AMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKLARSRADEARQAA 347
Cdd:COG0840  246 RMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELA 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 348 VGGEQMMTAV--------------NGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREV 413
Cdd:COG0840  326 EEGGEVVEEAvegieeiresveetAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEV 405

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 414 GLLARKSSHSTQTIQSLIN--------------HSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGES 479
Cdd:COG0840  406 RKLAERSAEATKEIEELIEeiqseteeaveameEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAG 485

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 556356509 480 IHQMTRQLQALNQVSRQTDVLVSEASNASERLHRESDLLLQAVSRFRL 527
Cdd:COG0840  486 TEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 279-526 5.89e-47

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 164.38  E-value: 5.89e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   279 QVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKLARSRADEARQAAVGGEQMMTAVN 358
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   359 GSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGLLARKSSHSTQTIQSLIN------ 432
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   433 --------HSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTRQLQALNQVSRQTDVLVSEA 504
Cdd:smart00283 161 neavaameESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 556356509   505 SNASERLHRESDLLLQAVSRFR 526
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 308-503 3.45e-36

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 133.52  E-value: 3.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 308 QAKELEEVTAHIADLETHVEGNTGYAKLARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNI 387
Cdd:cd11386    3 LSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 388 LALNAAIEAAHAGEQGRGFAVVAREVGLLARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLN 467
Cdd:cd11386   83 LALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAFE 162

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 556356509 468 DISLATLNQGESIHQMTRQLQALNQVSRQTDVLVSE 503
Cdd:cd11386  163 EIVASVEEVADGIQEISAATQEQSASTQEIAAAVEE 198
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 340-494 1.96e-31

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 119.46  E-value: 1.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  340 ADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGLLARK 419
Cdd:pfam00015   4 AQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAER 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  420 SSHSTQTIQSLIN--------------HSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTR 485
Cdd:pfam00015  84 SAQAAKEIEALIIeiqkqtndstasieSTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQ 163


                  ....*....
gi 556356509  486 QLQALNQVS 494
Cdd:pfam00015 164 AVARMDQVT 172
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 21-529 2.09e-73

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 242.99  E-value: 2.09e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  21 LLTGIFCIIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEGSW 100
Cdd:PRK15048   7 VVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSNQQSNAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 101 HSLMDEAQKSLAASQQAWQAWLALNPPQD-----EGLVNSYQLFFGAISEQAEGLVKTNsIDLFFAVPAQAFQTDFNDNF 175
Cdd:PRK15048  87 VELLDSARKTLAQAATHYKKFKSMAPLPEmvatsRNIDEKYKNYYTALTELIDYLDYGN-TGAYFAQPTQGMQNAMGEAF 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 176 ARYQQRSEKQAIQGRQSLMEQLSGLQRLFLFAPLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAAGDLSGIPpdVVRF 255
Cdd:PRK15048 166 AQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANTL--TIDG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 256 NREISQLSGSITAMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKL 335
Cdd:PRK15048 244 RSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQ 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 336 ARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGL 415
Cdd:PRK15048 324 ASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRN 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 416 LARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTRQLQALNQVSR 495
Cdd:PRK15048 404 LASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQ 483

                        490       500       510
                 ....*....|....*....|....*....|....
gi 556356509 496 QTDVLVSEASNASERLHRESDLLLQAVSRFRLPA 529
Cdd:PRK15048 484 QNASLVQESAAAAAALEEQASRLTQAVSAFRLAA 517
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
21-527 4.35e-73

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 242.17  E-value: 4.35e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  21 LLTGIFCIIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGVYFMQDKET-GSEGS 99
Cdd:PRK15041   7 IVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNNiGSGST 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 100 WHSLMDEAQKSLAASQQAWQAWLAL--NPPQDEG----LVNSYQLFFGAISEQAEgLVKTNSIDLFFAVPAQAFQTDFND 173
Cdd:PRK15041  87 VAELMQSASISLKQAEKNWADYEALprDPRQSTAaaaeIKRNYDIYHNALAELIQ-LLGAGKINEFFDQPTQGYQDGFEK 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 174 NFARYQQRSEK---QAIQGRQSLMEQLSGLQRLFLfapLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAAGDLsgIPP 250
Cdd:PRK15041 166 QYVAYMEQNDRlydIAVSDNNASYSQAMWILVGVM---IVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDL--VKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 251 DVVRFNREISQLSGSITAMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNT 330
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 331 GYAKLARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVA 410
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 411 REVGLLARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTRQLQAL 490
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 556356509 491 NQVSRQTDVLVSEASNASERLHRESDLLLQAVSRFRL 527
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRI 517
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
23-527 2.33e-63

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 216.09  E-value: 2.33e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  23 TGIFCIIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGV-----YFMQDKETgse 97
Cdd:PRK09793   9 TTLFLILILCGILQIGSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALNKAGTltalsYPADDIKT--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  98 gswhsLMDEAQKSLAASQQAWQAWLALNPPQDEG------LVNSYQLFFGAISEQAEGLvKTNSIDLFFAVPAQAFQTDF 171
Cdd:PRK09793  86 -----LMTTARASLTQSTTLFKSFMAMTAGNEHVralqkeTEKSFARWHNDLEHQATWL-ESNQLSDFLTAPVQGSQNAF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 172 NDNFARYQQR----SEKQAIQGRQSLmeQLSGLqrlfLFAPLVLLA---IAIAVWFAMaKWVISPLRRLIVHINQLAAGD 244
Cdd:PRK09793 160 DVNFEAWQLEinhvLEAASAQSQRNY--QISAL----VFISMIIVAaiyISSALWWTR-KMIVQPLAIIGSHFDSIAAGN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 245 LSgiPPDVVRFNREISQLSGSITAMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLET 324
Cdd:PRK09793 233 LA--RPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 325 HVEGNTGYAKLARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGR 404
Cdd:PRK09793 311 TVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGR 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 405 GFAVVAREVGLLARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMT 484
Cdd:PRK09793 391 GFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVA 470

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 556356509 485 RQLQALNQVSRQTDVLVSEASNASERLHRESDLLLQAVSRFRL 527
Cdd:PRK09793 471 QAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
28-527 1.83e-60

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 208.34  E-value: 1.83e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  28 IIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEGSWHSLMDEA 107
Cdd:COG0840   13 ALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 108 QKSLAASQQAWQAWLALNPPQDEGLVNSYQLFFGAISEQAEGLVKTNSIDLFFAVPAQAFQTDFNDNFARYQQRSEKQAI 187
Cdd:COG0840   93 LALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAAL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 188 QGRQSLMEQLSGLQRLflfapLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAAGDLSGIPPdvVRFNREISQLSGSIT 267
Cdd:COG0840  173 ALAAAALALALLAAAL-----LALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID--VDSKDEIGQLADAFN 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 268 AMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKLARSRADEARQAA 347
Cdd:COG0840  246 RMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELA 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 348 VGGEQMMTAV--------------NGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREV 413
Cdd:COG0840  326 EEGGEVVEEAvegieeiresveetAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEV 405

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 414 GLLARKSSHSTQTIQSLIN--------------HSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGES 479
Cdd:COG0840  406 RKLAERSAEATKEIEELIEeiqseteeaveameEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAG 485

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 556356509 480 IHQMTRQLQALNQVSRQTDVLVSEASNASERLHRESDLLLQAVSRFRL 527
Cdd:COG0840  486 TEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 279-526 5.89e-47

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 164.38  E-value: 5.89e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   279 QVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADLETHVEGNTGYAKLARSRADEARQAAVGGEQMMTAVN 358
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   359 GSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGLLARKSSHSTQTIQSLIN------ 432
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   433 --------HSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTRQLQALNQVSRQTDVLVSEA 504
Cdd:smart00283 161 neavaameESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 556356509   505 SNASERLHRESDLLLQAVSRFR 526
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 308-503 3.45e-36

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 133.52  E-value: 3.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 308 QAKELEEVTAHIADLETHVEGNTGYAKLARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNI 387
Cdd:cd11386    3 LSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 388 LALNAAIEAAHAGEQGRGFAVVAREVGLLARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLN 467
Cdd:cd11386   83 LALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAFE 162

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 556356509 468 DISLATLNQGESIHQMTRQLQALNQVSRQTDVLVSE 503
Cdd:cd11386  163 EIVASVEEVADGIQEISAATQEQSASTQEIAAAVEE 198
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 340-494 1.96e-31

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 119.46  E-value: 1.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  340 ADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQGRGFAVVAREVGLLARK 419
Cdd:pfam00015   4 AQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAER 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  420 SSHSTQTIQSLIN--------------HSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQMTR 485
Cdd:pfam00015  84 SAQAAKEIEALIIeiqkqtndstasieSTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQ 163


                  ....*....
gi 556356509  486 QLQALNQVS 494
Cdd:pfam00015 164 AVARMDQVT 172
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 48-189 1.13e-19

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 85.82  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   48 NQAQRNEQRNQLawQQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEgswhSLMDEAQKSLAASQQAWQAWLAL--N 125
Cdd:pfam02203  12 NDALREVYTNRL--QQQAALADAWLLLLQARLTLNRAGIAALLPDAPDAA----ELLARARESLAQSDAAWKAYLALprT 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556356509  126 PPQDEGLVN----SYQLFFGAISEQAEGLvKTNSIDLFFAVPAQAFQTDFNDNFARYQQRSEKQAIQG 189
Cdd:pfam02203  86 PDEEEALAAelkaKYDALQDGLAPLIAAL-RAGDLDAFFDQPTQKIQPLFEALYNAYLALRKFQNDAA 152
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 62-183 1.67e-17

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 78.90  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  62 QQQSRLDQARISLLAASDLLNRSGVYFMQDKETGSEGSWHSLMDEAQKSLAASQQAWQAWLAL--NPPQDEGLVN----S 135
Cdd:cd19407    5 QQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGGAAVAELLDQAKKSLAQAEKHFAQFKALpkLPGQDEALAAeleqS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 556356509 136 YQLFFGAISEQAEGLvKTNSIDLFFAVPAQAFQTDFNDNFARYQQRSE 183
Cdd:cd19407   85 YQAYHDALAELIQFL-EAGNIDAFLDQPTQGYQDAFEKAYNAYLAQNN 131
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 198-293 1.94e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 50.35  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 198 SGLQRLFLFAPLV--LLAIAIAVWFA--MAKWVISPLRRLIVHINQLAAGDLSGIPPdvVRFNREISQLSGSITAMQRGL 273
Cdd:COG5000    1 SGLQILFLLLLLLiaLLLLLLALWLAllLARRLTRPLRRLAEATRAVAAGDLSVRLP--VTGDDEIGELARAFNRMTDQL 78

                         90       100
                 ....*....|....*....|...
gi 556356509 274 QQLVTQVSEA---TTSMVENIGS 293
Cdd:COG5000   79 KEQREELEERrryLETILENLPA 101
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 62-184 8.45e-06

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 45.53  E-value: 8.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509    62 QQQSRLDQARISLLAASDLLNRSGVYFMQDKeTGSEGSwhSLMDEAQKSLAASQQAWQAWLAL--NPPQDEGLV----NS 135
Cdd:smart00319   5 YQQAALSLSRVLLLQARNNLNRAGIRMMQNN-IGSKAK--KLMTAASESLKQAEKNYKSYENMtaLPRADRALDaelkEK 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 556356509   136 YQLFFGAISEQAEgLVKTNSIDLFFAVPAQAFQTDFNDNFARYQQRSEK 184
Cdd:smart00319  82 FQQYITALQELIQ-ILGNGNLGAFFDQPTQGMQDGFDPAYRDWLQQAVA 129
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
224-278 9.90e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 39.92  E-value: 9.90e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 556356509   224 KWVISPLRRLIVHINQLAAGDLSGIPPdvVRFNREISQLSGSITAMQRGLQQLVT 278
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLP--VDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
222-275 1.17e-04

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 39.92  E-value: 1.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 556356509  222 MAKWVISPLRRLIVHINQLAAGDLSgiPPDVVRFNREISQLSGSITAMQRGLQQ 275
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLD--VRLPVSGRDEIGELARAFNQMAERLRE 53
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
3-514 2.68e-04

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 43.56  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509   3 LTQIFRRLAQRFFPRQFGLLTGIFCIIGLFSALQLSSSFLLTASLNQAQRNEQRNQLAWQQQSRLDQARISLLAASDLLN 82
Cdd:COG2770   13 LLLLLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509  83 RSGVYFMQDKETGSEGSWHSLMDEAQKSLAASQQAWQAWLALNPPQDEGLVNSYQLFFGAISEQAEGLVKTNSIDLFFAV 162
Cdd:COG2770   93 ALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 163 PAQAFQTDFNDNFARYQQRSEKQAIQGRQSLMEQLSGLQRLFLFAPLVLLAIAIAVWFAMAKWVISPLRRLIVHINQLAA 242
Cdd:COG2770  173 LLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAA 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 243 GDLSGIPPdvVRFNREISQLSGSITAMQRGLQQLVTQVSEATTSMVENIGSLAQGNQKLYQQSTRQAKELEEVTAHIADL 322
Cdd:COG2770  253 GDLDVRIP--VSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLL 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 323 ETHVEGNTGYAKLARSRADEARQAAVGGEQMMTAVNGSMQTIVDRSSEMRGIVAMIDSVAFQTNILALNAAIEAAHAGEQ 402
Cdd:COG2770  331 ELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALE 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356509 403 GRGFAVVAREVGLLARKSSHSTQTIQSLINHSLQGIEEGSQVVNRLEENLQQVTGLVANLSSLLNDISLATLNQGESIHQ 482
Cdd:COG2770  411 ELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELL 490

                        490       500       510
                 ....*....|....*....|....*....|..
gi 556356509 483 MTRQLQALNQVSRQTDVLVSEASNASERLHRE 514
Cdd:COG2770  491 LLEEEEEAGAAAEELAEELLLLEGLLLLLLLE 522
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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