NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|556281318|ref|WP_023289355|]
View 

MULTISPECIES: MFS transporter [Klebsiella]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-457 3.44e-58

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 195.85  E-value: 3.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVA 180
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 181 laalallrgtpesrsasasqqkldvggllslIAGLVLVnlfiskghgwgwssplslsmlagaliagavfirsglrkgeaa 260
Cdd:cd17321  161 -------------------------------LVALLLA------------------------------------------ 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 261 lidfalfrnRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd17321  168 ---------RTFSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 340 AGPVLTAIAIGLISctFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd17321  239 AGLLLTAVGLLLLA--LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 556281318 420 ASLFALFLPLGM----------------AHAAQYALWFNAALCLGAMAVSALLL 457
Cdd:cd17321  317 GALLTAGLSANLgdsgvaallsaaaaafAAGFHLAFLVAAALALLAALLALLLP 370
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-457 3.44e-58

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 195.85  E-value: 3.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVA 180
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 181 laalallrgtpesrsasasqqkldvggllslIAGLVLVnlfiskghgwgwssplslsmlagaliagavfirsglrkgeaa 260
Cdd:cd17321  161 -------------------------------LVALLLA------------------------------------------ 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 261 lidfalfrnRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd17321  168 ---------RTFSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 340 AGPVLTAIAIGLISctFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd17321  239 AGLLLTAVGLLLLA--LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 556281318 420 ASLFALFLPLGM----------------AHAAQYALWFNAALCLGAMAVSALLL 457
Cdd:cd17321  317 GALLTAGLSANLgdsgvaallsaaaaafAAGFHLAFLVAAALALLAALLALLLP 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-423 1.58e-23

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 102.84  E-value: 1.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   17 LLVGIVLSVLTfwlfaQSVINV-VPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:TIGR00711   7 LMLGTFMAVLD-----STIVNVaIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  176 SIAVALAALALLRGTPESRSASASqQKLDVGGLLSLIAGLVLVNLFISKGHGWGW-SSPLSLSMLAGALIAGAVFIRSGL 254
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  255 RKgEAALIDFALFRNRAYGAAVLSNFLLN-GAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:TIGR00711 241 TD-DNPLVDLRLFKYRNFTIGCVYMSLLGlGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  334 ARLPMMAGPVLTAIAIGLISCTFLDKALYIGVVFGSNVLfGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIR-GFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGS 398

                         410
                  ....*....|
gi 556281318  414 MGIAVTASLF 423
Cdd:TIGR00711 399 IGTALITTIL 408
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 16-296 8.93e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 92.18  E-value: 8.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:COG0477   14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:COG0477   94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 176 SIAVALAALALLRGTPESRSASASQQKLDVGGLLSLIAGLVLVNLFISKGHGWGWSSPLSLSMLAGALIAGAVFIRSGLR 255
Cdd:COG0477  174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 556281318 256 KGEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWL 296
Cdd:COG0477  254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
PRK14995 PRK14995
SmvA family efflux MFS transporter;
18-418 3.04e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 84.01  E-value: 3.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  18 LVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAM 97
Cdd:PRK14995   8 LVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  98 LVLAQGPGLFLAGRVLQGLSAACIMPATLALIK-TWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:PRK14995  88 AAFSPTASWLIATRALLAIGAAMIVPATLAGIRaTFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLIN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 177 IA-VALAALALLRGTPesRSASASQQKLDVGGLLSLIAGLVLVNLFISKG-HGWGWSSPLSLSMLAGALIAGAvFIRSGL 254
Cdd:PRK14995 168 VPiVLVVMGLTARYVP--RQAGRRDQPLNLGHALMLIVAILLLVYSAKTAlKGFLSLWVTSLTLLTGALLLGL-FIRTQL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 255 RkGEAALIDFALFRNRAYGAAV-LSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:PRK14995 245 A-ASRPMIDMRLFTHRIILSGVvMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 334 ARLPMMAGPVLTAIAigLISCTFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:PRK14995 324 LRLVATGGMALSALS--FYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAG 401


                 ....*
gi 556281318 414 MGIAV 418
Cdd:PRK14995 402 LGIAI 406
MFS_1 pfam07690
Major Facilitator Superfamily;
17-415 1.87e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.15  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   17 LLVGIVLSVLTFWLFAqsvINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSA 96
Cdd:pfam07690   1 LFLAAFLAALGRSLLG---PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   97 MLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  177 iavalaalallrgtpesrsasasqqkldvgGLLSLIAGLVLvnlfiskghgwgwssplslsmLAGALIAGAVFIRSGLRK 256
Cdd:pfam07690 158 ------------------------------AILSLLAAVLL---------------------LLPRPPPESKRPKPAEEA 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  257 GEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARL 336
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556281318  337 PMMAGpvLTAIAIGLISCTFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:pfam07690 267 RLLLA--LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-457 3.44e-58

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 195.85  E-value: 3.44e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVA 180
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 181 laalallrgtpesrsasasqqkldvggllslIAGLVLVnlfiskghgwgwssplslsmlagaliagavfirsglrkgeaa 260
Cdd:cd17321  161 -------------------------------LVALLLA------------------------------------------ 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 261 lidfalfrnRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd17321  168 ---------RTFSGAVLAAFLLGAALGGLLfLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 340 AGPVLTAIAIGLISctFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd17321  239 AGLLLTAVGLLLLA--LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALL 316

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 556281318 420 ASLFALFLPLGM----------------AHAAQYALWFNAALCLGAMAVSALLL 457
Cdd:cd17321  317 GALLTAGLSANLgdsgvaallsaaaaafAAGFHLAFLVAAALALLAALLALLLP 370
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 33-458 1.01e-28

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 116.52  E-value: 1.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  33 QSVINV-VPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGR 111
Cdd:cd17503   12 TTIVNVaLPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 112 VLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAValaalallrgtp 191
Cdd:cd17503   92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI------------ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 192 esrsasasqqkldvgGLLSLIAglvlvnlfiskghgwgwssplslsmlagaliagavfirsglrkgeAALIDFALFRNRA 271
Cdd:cd17503  160 ---------------GILALLL---------------------------------------------APLLDLRLFKDRN 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 272 YGAAVLSNFLLNGAI-GTMMIASIWLQQGHHLTPLESGMMTL-GYLVTVLAMIRVGeKLLQRYGARLPMMAGPVLTAIAI 349
Cdd:cd17503  180 FTLGLLLSFLLGLGLfGAMFLLPLYLQNVLGYSAFESGLVLApGGLASAILSPLVG-RLLDKFGPRLLLLAGLLLLALGT 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 350 GLISCTFLDKALYIgvVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALF--- 426
Cdd:cd17503  259 LLLAFLTPDTSLWL--IILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRtqf 336

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 556281318 427 -------LPLGMAHAAQYALWFNAALCLGAMAVSALLLP 458
Cdd:cd17503  337 hhsrlseLLAQQVQKQALIIAFNDAFLVSAILLLVGLLL 375
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 17-423 1.58e-23

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 102.84  E-value: 1.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   17 LLVGIVLSVLTfwlfaQSVINV-VPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:TIGR00711   7 LMLGTFMAVLD-----STIVNVaIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  176 SIAVALAALALLRGTPESRSASASqQKLDVGGLLSLIAGLVLVNLFISKGHGWGW-SSPLSLSMLAGALIAGAVFIRSGL 254
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  255 RKgEAALIDFALFRNRAYGAAVLSNFLLN-GAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:TIGR00711 241 TD-DNPLVDLRLFKYRNFTIGCVYMSLLGlGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  334 ARLPMMAGPVLTAIAIGLISCTFLDKALYIGVVFGSNVLfGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPQFIR-GFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGS 398

                         410
                  ....*....|
gi 556281318  414 MGIAVTASLF 423
Cdd:TIGR00711 399 IGTALITTIL 408
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 16-296 8.93e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 92.18  E-value: 8.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:COG0477   14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:COG0477   94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 176 SIAVALAALALLRGTPESRSASASQQKLDVGGLLSLIAGLVLVNLFISKGHGWGWSSPLSLSMLAGALIAGAVFIRSGLR 255
Cdd:COG0477  174 NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 556281318 256 KGEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWL 296
Cdd:COG0477  254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-413 2.92e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 91.57  E-value: 2.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 176 SIAValaalallrgtpesrsasasqqkldvgGLLSLIAGLVLVnlfiskghgwgwssPLSLSMLAGALIAGAvfirsglr 255
Cdd:COG2814  170 NAVL---------------------------ALLALLLLLRLL--------------PESRPAARARLRGSL-------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 256 kgeaalidFALFRNRAYGAAVLSNFLLNGAIGTMM-IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:COG2814  201 --------RELLRRPRLLLLLLLAFLLGFGFFALFtYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556281318 335 RLPMMAGPVLTAIAIGLISCTFLDKALYIGVvfgsnVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:COG2814  273 RRLLLIGLLLLALGLLLLALAGSLWLLLLAL-----FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-460 4.39e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 85.31  E-value: 4.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVf 175
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 176 siavalaalallrgtpesrsasasqqkldVGGLLSLIAGLVLVnlfiskghgwgwssplslsmlagaliagavfirsglr 255
Cdd:COG2271  169 -----------------------------ILGLPGLLLALLRF------------------------------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 256 kgeaalidfalfrnrayGAAVLSNFLLNGAIGTMMI-ASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:COG2271  183 -----------------WLLALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 335 RLPMMAGPVLTAIAIGLISCTFLDKALYIGVVFgsnVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAM 414
Cdd:COG2271  246 RRKLVLAIGLLLAALALLLLALLPSPALAIALL---FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL 322

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 556281318 415 GIAVTASLFALFlplgmahAAQYALWFNAALCLGAMAVSALLLPRA 460
Cdd:COG2271  323 GPLLVGYLLDAT-------GYQAAFLLLAALALLAALLALLLLRET 361
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 21-457 6.53e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 84.94  E-value: 6.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVA 180
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 181 laalallrgtpesrsasasqqkldvggllslIAGLVLVNLFISKGHGWGWSSPLSLSMLAGALiagavfirsglrkgeaa 260
Cdd:cd17325  161 -------------------------------LLALVLALLLLPEPRPPPNKRAVSAARLRSGL----------------- 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 261 lidFALFRNRAYGAAVLSNFLLNGAIGTMMIA-SIWLQQGHHLTPLESGMM-TLGYLVTVLAMIRVGeKLLQRYGARLPM 338
Cdd:cd17325  193 ---RLLLRDRRLLALFLAIFVLAFAFGALEPFlPLYAAELGGLSPAQIGLLfGAQGLASALSQPPAG-KLSDRIGRKPLI 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 339 MAGPVLTAIAIGLISctfldKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAV 418
Cdd:cd17325  269 LIGLLLSAVALLLLP-----LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 556281318 419 TASLFALFlplgmahAAQYALWFNAALCLGAMAVSALLL 457
Cdd:cd17325  344 GGFLYDAF-------GFATPFLAAAALLLLAAVLFLLLR 375
PRK14995 PRK14995
SmvA family efflux MFS transporter;
18-418 3.04e-17

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 84.01  E-value: 3.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  18 LVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAM 97
Cdd:PRK14995   8 LVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  98 LVLAQGPGLFLAGRVLQGLSAACIMPATLALIK-TWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:PRK14995  88 AAFSPTASWLIATRALLAIGAAMIVPATLAGIRaTFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLIN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 177 IA-VALAALALLRGTPesRSASASQQKLDVGGLLSLIAGLVLVNLFISKG-HGWGWSSPLSLSMLAGALIAGAvFIRSGL 254
Cdd:PRK14995 168 VPiVLVVMGLTARYVP--RQAGRRDQPLNLGHALMLIVAILLLVYSAKTAlKGFLSLWVTSLTLLTGALLLGL-FIRTQL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 255 RkGEAALIDFALFRNRAYGAAV-LSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG 333
Cdd:PRK14995 245 A-ASRPMIDMRLFTHRIILSGVvMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 334 ARLPMMAGPVLTAIAigLISCTFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:PRK14995 324 LRLVATGGMALSALS--FYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAG 401


                 ....*
gi 556281318 414 MGIAV 418
Cdd:PRK14995 402 LGIAI 406
MFS_1 pfam07690
Major Facilitator Superfamily;
17-415 1.87e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 80.15  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   17 LLVGIVLSVLTFWLFAqsvINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSA 96
Cdd:pfam07690   1 LFLAAFLAALGRSLLG---PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   97 MLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  177 iavalaalallrgtpesrsasasqqkldvgGLLSLIAGLVLvnlfiskghgwgwssplslsmLAGALIAGAVFIRSGLRK 256
Cdd:pfam07690 158 ------------------------------AILSLLAAVLL---------------------LLPRPPPESKRPKPAEEA 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  257 GEAALIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARL 336
Cdd:pfam07690 187 RLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556281318  337 PMMAGpvLTAIAIGLISCTFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:pfam07690 267 RLLLA--LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 62-424 1.29e-15

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 77.60  E-value: 1.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  62 LFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRA 141
Cdd:cd17502   41 LTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 142 VSFWViGSWGGSGLCS-FVGGAIATGLGWRWIFVFSIAValaalallrgtpesrsasasqqkldvgGLLSLIAGLVlvnl 220
Cdd:cd17502  121 QGYIG-AVFGIASVAGpLIGGAFTDHLSWRWCFYINLPI---------------------------GGLALALLRT---- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 221 fiskghgwgwsspLSLSMLAGALIAGAVFirsglrkgeaalidfalfrnraygaaVLSNFLlngaigtmmiaSIWLQQGH 300
Cdd:cd17502  169 -------------ILLSSIFGFLFGGALF--------------------------GLIYYL-----------PLYFQLVL 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 301 HLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYG-ARLPMMAGPVLTAIAIGLIscTFLDKALYIGVVFGSNVLFGLGLGC 379
Cdd:cd17502  199 GDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSVGAGLL--TTLTLDTSKWLLIGYLILLGLGLGI 276

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 556281318 380 YATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFA 424
Cdd:cd17502  277 GFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDVFLV 321
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
16-460 3.71e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 70.68  E-value: 3.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVf 175
Cdd:COG2223   85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 176 siavalaalallrgtpesrsasasqqkldVGGLLSLIAGLVLVNLFISKGHGWGWSSPLSLSMLagaliagavfirsglr 255
Cdd:COG2223  164 -----------------------------ILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ---------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 256 kgeaalidFALFRNRAYGAAVLSNFLLNGA-IGTMMIASIWLQQGHHLTPLESGMMT-LGYLVTVLAMIrVGEKLLQRYG 333
Cdd:COG2223  199 --------LEALRDPRFWLLSLLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAaLFALLGALGRP-LGGWLSDRIG 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 334 ARLPMMAGPVLTAIAIGLISCTFLDKALYIGVVFGsnVLFGLGLGCYATPStdTAVANAPENKIGVASGIYKMGSSLGGA 413
Cdd:COG2223  270 GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLL--LGLALGGGNGAVFA--LVPDIFPTKNAGAVYGLVGAAGGLGGF 345

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 556281318 414 MGIAVTASLFALFlplgmaHAAQYALWFNAALCLGAMAVSALLLPRA 460
Cdd:COG2223  346 LGPLLFGALLDAT------GSYTAAFLVFAVLALVALVLTLLLYRRP 386
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 54-423 9.60e-13

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 69.96  E-value: 9.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  54 TLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAAC--IMPATLALI-- 129
Cdd:cd06179   35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTqgLGAAVASELvp 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 130 ---KTWYQGRARQRAVSFWVIGSWGGSGLcsfvggAIATGLGWRWIFVFSIAVALAALALL--------RGTPESRSASA 198
Cdd:cd06179  115 nkyRGLVQGVVNLVASPGSALGPLIAGAL------VEANAAGWRWIFYINAIFNALALILLfffyhpppRPQLHGSSTRQ 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 199 SQQKLDVGGLLSLIAGLVLVNLFISKGHG-WGWSSPLSLSMLA-GALIAGAVFIRSGLRKGEAALIDFALFRNRAYGAAV 276
Cdd:cd06179  189 KLKRLDWVGLFLLIAGLVLFLLGLSWGGNpYPWSSAHVIAPLViGGVLLIAFGLYEWKGTKDGLLPPRLLFRGRNFALIL 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 277 LSNFLlnGAIGTMMIASIWLQQGHHLT---PLESGMMTLG-YLVTVLAMIRVGeKLLQRYG-ARLPMMAGPVLTAIAIGL 351
Cdd:cd06179  269 IVAFV--EGMIFYSLNIFWPQQISLLFttdPLKAGLYQLPfGLGTLFGAILAG-LLLTKIKhIKWQLVAGFVLFTAFLAL 345

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556281318 352 IS-CTFLDKALYIGVvfgsNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLF 423
Cdd:cd06179  346 LAlITPDNKALAIAF----SVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSIL 414
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 34-415 5.38e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 67.21  E-value: 5.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  34 SVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVL 113
Cdd:cd17474   17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 114 QGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIAtGLGWRWIFVFSIAvalaalallrgtpes 193
Cdd:cd17474   97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAA--------------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 194 rsasasqqkldvgglLSLIAGLVLVNLFISKGHGWGWSSPLSLSMLAGALIAGAVFIRSGLrkgeAALIDFALFRNRAYG 273
Cdd:cd17474  161 ---------------LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVS----AFLYFFLYFAFLTYL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 274 AAVLSNFLLNGAIGTMMIASIWLqqghhltplesgmmtlgyLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIGLIS 353
Cdd:cd17474  222 PFLLELLYGISPIIIGLLFAGWS------------------VLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLG 283

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556281318 354 ctFLDKalyIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:cd17474  284 --FVPS---LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 21-175 1.16e-10

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 63.05  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17476    3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQ-GRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17476   83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF 158
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 21-175 1.49e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.59  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVI--NVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAML 98
Cdd:cd17323    2 FIISFLTFVVTFGSSIysPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556281318  99 VLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17323   82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF 158
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 40-432 1.51e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.57  E-value: 1.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  40 PAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAA 119
Cdd:cd17324   23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 120 CIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSiavalaalallrgtpesrsasas 199
Cdd:cd17324  103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI----------------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 200 qqkldvgGLLSLIAGLVLVNLFiskghgwgwssPLSLSMLAGALIAGAVFirsglrkgeaalidFALFRNRAYGAAVLSN 279
Cdd:cd17324  160 -------AVLALLAALLLWRLL-----------PSLPPKKPGSLGLLSSL--------------LLLLRNPRLRLAYLIT 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 280 FLLNGAIGTMM--IASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGeKLLQRYGARLPMMAGPVLTAIAIGLISCTFL 357
Cdd:cd17324  208 FLLFGGFFALYtyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG-RLADRGGRRALLIALLLLAAALLLLTLLGPS 286

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556281318 358 DKALYIGVvfgsnVLFGLGLGCYATPSTDTAVANAPENKIGVAS---GIYKMGSSLGGAMGIAVTASLFALFLPLGMA 432
Cdd:cd17324  287 PLLLLVGL-----VLWGLGFFAAHSALQTRVLRLAPEARGLASSlylAAYNLGGALGAALGGLVLDHGGWAGVGWVGA 359
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
17-175 3.08e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 61.81  E-value: 3.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  17 LLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSA 96
Cdd:COG2807   19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556281318  97 MLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRaRQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:COG2807   99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV 176
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 21-458 1.01e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 59.89  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVIN-VVPAMKSSLDISLETLT-LAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAML 98
Cdd:cd17473    3 TLLLASTLTVMAGAAIApALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  99 VLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATgLGWRWIFVFSIA 178
Cdd:cd17473   83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 179 VALAALALLRGTPESRSASASQQKLDVGGLLSLIAGLVLVNLFIskghgwgwssplslsMLAGALIAGAVFIRSGLrkge 258
Cdd:cd17473  162 ALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFL---------------AFLAMLLFYVIPIQLPF---- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 259 aalidfaLFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQqghhltplesgmmtlgylvtvlamirvgeKLLQRYGARLPM 338
Cdd:cd17473  223 -------LLQERGGGSAALIGLALAIASLAGAIGALLFG-----------------------------RLKRRLGKRRLL 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 339 MAGPVLTAIAIGLISCtfldkALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLggamGIAV 418
Cdd:cd17473  267 AIGFALMALGFLLLAL-----ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL----GQFL 337

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 556281318 419 TASLFALFLPLGMAHAAQYALwfnAALCLGAMAVSALLLP 458
Cdd:cd17473  338 SPLVLGPLVNLTGGLSGAFLI---LGVLALVLAIVLLLLR 374
PRK10504 PRK10504
putative transporter; Provisional
 23-348 1.05e-09

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 60.52  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  23 LSVLTFWLFAQS-----VINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAM 97
Cdd:PRK10504  12 LWIVAFGFFMQSldttiVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  98 LVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSI 177
Cdd:PRK10504  92 CALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 178 AVALAALALLRGTPESRSASAsqQKLDVGGLLSLIAGLVLVNLFISKGHGWGWSsPLSLSMLAGALIAGAVFIRSGLRKG 257
Cdd:PRK10504 172 PVGIIGAIATLMLMPNYTMQT--RRFDLSGFLLLAVGMATLTLALDGSKGLGLS-PLAIAGLVAVGVVALLLYLLHARNN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 258 EAALIDFALFRNRAYGAAVLSNFLlnGAIGTMMI---ASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGA 334
Cdd:PRK10504 249 NRALFSLKLFRTRTFSLGLAGSFA--GRIGSGMLpfmTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGY 326

                        330
                 ....*....|....
gi 556281318 335 RLPMMAGPVLTAIA 348
Cdd:PRK10504 327 RRVLVATTLGLALV 340
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 22-456 3.89e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 58.36  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  22 VLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLA 101
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 102 QGPGLFLAGRVLQGLSAAcIMPATLALIKTwYQGRARQRAVSFWVIGSWG-GSGLCSFVGGAIATGLGWRWIFVFSIAVa 180
Cdd:cd17504   82 PNLPVLIAGRALQGIGGA-VFPLAFALVRE-EFPPERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPV- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 181 laalallrgtpesrsasasqqkldvgGLLSLIAglvlvnlfiskghgwgwssplslsmlagaliagavfirsglrkgeAA 260
Cdd:cd17504  159 --------------------------AVLLAAL---------------------------------------------VP 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 261 LIDFALFRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQ-----GHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGAR 335
Cdd:cd17504  168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 336 LPMMAGpvLTAIAIGLISCTFLDKALYIGVVFGsnVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMG 415
Cdd:cd17504  248 RVLLIG--LVISAVGLLLLALLHSSLWALVVAL--LLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 556281318 416 IAVTASLFALFLPLGMAH------AAQYALWFNAALCLGAMAVSALL 456
Cdd:cd17504  324 PAIAGAILTTYTVSITSGgvptegAYVLAFLIGAALALAALLLSLLI 370
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 40-175 5.10e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.97  E-value: 5.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  40 PAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAA 119
Cdd:cd17320   23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556281318 120 CIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17320  103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVF 158
2_A_01_02 TIGR00880
Multidrug resistance protein;
71-179 2.93e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 52.65  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   71 SGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSW 150
Cdd:TIGR00880  18 SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIA 97

                          90       100
                  ....*....|....*....|....*....
gi 556281318  151 GGSGLCSFVGGAIATGLGWRWIFVFSIAV 179
Cdd:TIGR00880  98 LGPLLGPPLGGVLAQFLGWRAPFLFLAIL 126
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 40-175 1.03e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  40 PAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAA 119
Cdd:cd17319   27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEA 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556281318 120 CIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVF 175
Cdd:cd17319  107 GFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 21-453 2.93e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.43  E-value: 2.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAva 180
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 181 laalallrgtpesrsasasqqkldvgGLLSLIAGLVLvnlfiskghgWGWSSPLSLSMLAGALIAGAVFIRSGLRKgeaa 260
Cdd:cd06174  159 --------------------------AALALLAAILL----------LLVVPDPPESARAKNEEASSKSVLKLLKR---- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 261 lidfaLFRNRAYGAAVLSNFLLNGAIGTMMIASIW-LQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMM 339
Cdd:cd06174  199 -----VLKNPGLWLLLLAIFLVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 340 agpvLTAIAIGLISCTFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVT 419
Cdd:cd06174  274 ----LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349

                        410       420       430
                 ....*....|....*....|....*....|....
gi 556281318 420 ASLFAlflplgMAHAAQYALWFNAALCLGAMAVS 453
Cdd:cd06174  350 GFLLA------ATFGLTGAFLVLAVLLLLAAILL 377
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 72-428 7.62e-07

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 51.54  E-value: 7.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  72 GGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQ-------GLSAACIM---------------PATLALI 129
Cdd:cd17322   58 AKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYnagytglNLLLTLILadfsslknrgfasaiPSLPYII 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 130 KTWYQGRARQRAV--SFWvigSWGgSGLCSFVGGAIATglgwrwIFVFSIAVA---LAALALLRGTPESRSASASQ---- 200
Cdd:cd17322  138 TTWIGGNIAQAALpnSNW---RWG-YGMWAIILPLSSL------PLVLCLLYMqrkARKDGEIKELKNQETEEQTGglsq 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 201 ------QKLDVGGLLSLIAGL--VLVNLFISKGHGWGWSSPLSLSMLAGALIAGAVFIRSGLRKGEAALIDFALFRNRAY 272
Cdd:cd17322  208 nlvklfWKLDIFGVILLTAGLglILVPLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTI 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 273 GAAVLSNFL--LNGAIGTMMIASIwLQQGHHLTPLESGMMTLGY-LVTVLAMIRVGekLLQRYGARLPM--MAGPVLTAI 347
Cdd:cd17322  288 LAACLIDFFyfFSYYIFSDYLYTV-LQVAVGESITSATRITNLYsFVSTVAGIFVG--FLIRKTRRYKVlvIIGVPLYIV 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 348 AIGLIsCTFLDKALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALFL 427
Cdd:cd17322  365 GMGLL-IRYRGGSGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTL 443


                 .
gi 556281318 428 P 428
Cdd:cd17322  444 P 444
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 21-218 1.04e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.67  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLALIkTWYQGRARQ-RAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAV 179
Cdd:cd17489   81 ATSVALLLVLRLIHGIGWGAFTTAAATLV-ADIIPPSRRgEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 556281318 180 ALAALALLRGTPESRSASASQQKLDVGGLLSLIAGLVLV 218
Cdd:cd17489  160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLP 198
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 47-322 1.51e-06

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 50.03  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   47 DISLETLTLAVSLSALFSGCFV--VASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPA 124
Cdd:TIGR00893  23 DLGLSAAQYGYVFSAFSWGYVVgqFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLLGAAEAPFFPG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  125 TLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSiavalaalallrgtpesrsasasqqkld 204
Cdd:TIGR00893 103 IILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE---------------------------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  205 vgGLLSLIAGLVLVNLFISKGHGWGWSSPLSLSMLAGALIA-GAVFIRSGLRKGEaalIDFALFRNRAYGAAvLSNFLLN 283
Cdd:TIGR00893 155 --GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAeQQGKGPSTPKKYQ---IKELLKDRRVWGLA-LGQFLVN 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 556281318  284 GAIGTMMI-ASIWLQQGHHLTPLESGMMT-LGYLVTVLAMI 322
Cdd:TIGR00893 229 IGLGFFLTwFPTYLVQERGLSILEAGFMAsLPGIVGFIGMI 269
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-177 1.53e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINV-VPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVG 94
Cdd:COG0738    7 RRALIAIYLLFFLWGFATALWGPlIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  95 SAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFV 174
Cdd:COG0738   87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLP 166


                 ...
gi 556281318 175 FSI 177
Cdd:COG0738  167 YLI 169
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 38-190 1.91e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  38 VVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLS 117
Cdd:cd17365   21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556281318 118 AACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVALAALALLRGT 190
Cdd:cd17365  101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT 173
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 38-177 2.59e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.14  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  38 VVPAMKSSLDISLETLTLAVSLSALFSGCFVVAS--GGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQG 115
Cdd:cd17316   21 VAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALlfGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556281318 116 LSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAI----ATGLGWRWIFVFSI 177
Cdd:cd17316  101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGA 166
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 38-215 1.20e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 47.30  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  38 VVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLS 117
Cdd:cd17371   21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 118 AACIMPATLALIKTWYQGRARQRAV----SFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAVALAALALLRGTPES 193
Cdd:cd17371  101 FGGEWAAGAALMAEYVPARHRGKALgyvqSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEP 180

                        170       180
                 ....*....|....*....|..
gi 556281318 194 RSASASQQKLDVGGLLSLIAGL 215
Cdd:cd17371  181 PQWQAARAARRHFADRPSLREL 202
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 23-193 1.57e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 46.99  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   23 LSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMrmTTLGLGLSIVGSAMLVLAQ 102
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPR--VFLPIGLILCAIVNLFFGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  103 GPGL--FLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGS-WGGSGLCSFVGGAIATGLGWRWIFVFS--- 176
Cdd:TIGR00881  80 STSLwvMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPgii 159

                         170
                  ....*....|....*...
gi 556281318  177 -IAVALAALALLRGTPES 193
Cdd:TIGR00881 160 aIIVSLICFLLLRDSPQS 177
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 107-175 1.76e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 46.86  E-value: 1.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556281318 107 FLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWvigsWGGSGLCSFVGGAIATGL----------GWRWIFVF 175
Cdd:cd17327   97 LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFF----YAAAGLGSIFGGLLAYGVfkilgvgglaGWRWLFII 171
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 16-174 1.86e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.88  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:cd17355    3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGP-GLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFV 174
Cdd:cd17355   83 VLLALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 22-179 3.09e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 46.08  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  22 VLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMttLGLGLSIVGSAMLVLA 101
Cdd:cd17475    2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV--LAVGLLLMGAAALLMA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 102 QGPG--LFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIAV 179
Cdd:cd17475   80 LVGSypVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 71-415 4.02e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 45.81  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   71 SGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSW 150
Cdd:TIGR00895  72 FGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  151 GGSGLCSFVGGAIATGLGWRWIFVF-SIAVALAALALLRGTPESRSASASQQKLDVGGLLSLIAGLVLVNlfiskghgwg 229
Cdd:TIGR00895 152 IGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAE---------- 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  230 wssPLSLSMLAGALIAGAVFIRSGLRKGEAALIDFALFrnRAYGAAVLSNFLLNGAIGTMMIasiwlQQGHHLTpLESGM 309
Cdd:TIGR00895 222 ---AQSALPEQKSTQGTKRSVFKALFQGKTARITVLLW--LLYFMLLVGVYFLTNWLPKLMV-----ELGFSLS-LAATG 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  310 MTLGYLVTVLAMIRVGeKLLQRYGARlPMMAGPVLTAIAIGLISCTF--LDKALYIGVVFGSNVLFGL-GLGCYATPSTD 386
Cdd:TIGR00895 291 GALFNFGGVIGSIIFG-WLADRLGPR-VTALLLLLGAVFAVLVGSTLfsPTLLLLLGAIAGFFVNGGQsGLYALMALFYP 368

                         330       340
                  ....*....|....*....|....*....
gi 556281318  387 TAVANapeNKIGVASGIYKMGSSLGGAMG 415
Cdd:TIGR00895 369 TAIRA---TGVGWAIGIGRLGAIIGPILA 394
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-155 4.22e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 4.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGL 155
Cdd:COG2814  288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 59-176 8.62e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 44.53  E-value: 8.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  59 LSALFSGCFV--VASGGLADKFGRMRMttlgLGLSIVGSAMLVL------AQGPGLFLAGRVLQGLSAACIMPATLALIK 130
Cdd:cd17318   62 LSSFFYGYILtqIPGGYLAEKYGAKRV----LGYSILITALLTLltplaaRGGYGALIVLRILQGLAQGVTFPAMHALWA 137

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 556281318 131 TWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFS 176
Cdd:cd17318  138 KWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIF 183
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 16-173 8.93e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.57  E-value: 8.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  16 RLLVGIVLSVLTFWLFAQSVINVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGS 95
Cdd:cd17312    3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556281318  96 AMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIF 173
Cdd:cd17312   83 IFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
268-460 1.34e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 268 RNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMM-TLGYLVTVLAMIRVGeKLLQRYGARLPMMAGPVLTA 346
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLfAIPVLVGALLRIPLG-FLVDRFGPRRVLLIGLLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 347 IAIGLISCtfldkALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALF 426
Cdd:COG2223   82 IGLLLLAL-----AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 556281318 427 lplgmahAAQYALWFNAALCLGAMAVSALLLPRA 460
Cdd:COG2223  157 -------GWRNAFLILGILLLVVAVLAWLFLRDP 183
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
267-463 1.73e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.42  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 267 FRNRAYGAAVLSNFLLNGAIGTMMIASIWLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTA 346
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 347 IAIGLISCtfldkALYIGVVFGSNVLFGLGLGCYATPSTDTAVANAPENKIGVASGIYKMGSSLGGAMGIAVTASLFALF 426
Cdd:COG2814   87 LGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 556281318 427 lplgmahAAQYALWFNAALCLGAMAVSALLLPRASHS 463
Cdd:COG2814  162 -------GWRWVFLVNAVLALLALLLLLRLLPESRPA 191
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 55-172 1.89e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 43.34  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  55 LAVSLSALFSGCFV--VASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTW 132
Cdd:cd17317   27 VALVQTIFFLGVLIgsLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 556281318 133 YQGRARQRAVS----FWVIGSWGGSGLCSFVGgaiatglGWRWI 172
Cdd:cd17317  107 VGPKYRSFVGIlfglFWALGYMLLALLAYLIR-------DWRWL 143
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 38-176 2.20e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.38  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  38 VVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLS 117
Cdd:cd17328   21 VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIG 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 118 AACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIAT-GLGWRWIFVFS 176
Cdd:cd17328  101 EASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVT 160
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
205-455 3.74e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 205 VGGLLSLIAGLVLVNLFI-SKGHGWGWSSPLSLSMLAGALIAGAVFIRSGLRKGEAALIDF----ALFRNRAYGAAVLSN 279
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGgDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKeslkALLKNRPFLLLLLAY 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 280 FLLNGAIGTMMIASI-WLQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIGLIsctFLD 358
Cdd:COG2211  238 LLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 359 KALYIGVVFGSNVLFGLGLGCYATPS----TDTAVANAPENKI---GVASGIYKMGSSLGGAMGIAVTASLFALF-LPLG 430
Cdd:COG2211  315 GPGNLWLLLVLAALAGIGLGAILVLPwamlADVVDYDEWKTGRrreGLYFGIFTFAIKLGQALAGALAGLLLALFgYVAG 394

                        250       260
                 ....*....|....*....|....*
gi 556281318 431 MAHAAQYALWFNAALCLGAMAVSAL 455
Cdd:COG2211  395 AAQSPSALTGIRLLFFLLPAVLLLL 419
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
21-168 4.26e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVIN--VVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAML 98
Cdd:COG2211  232 LLLLAYLLFFLALALVAalLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556281318  99 VLAQG--PGLFLAGRVLQGLSAACIMPATLALI------KTWYQGRaRQRAVSFwvigswGGSGLCSFVGGAIATGLG 168
Cdd:COG2211  312 FFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDEWKTGR-RREGLYF------GIFTFAIKLGQALAGALA 382
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 295-457 4.27e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 42.61  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 295 WLQQGHHLTPLESGMM-TLGYLVTVLAMIRVGEkLLQRYGARLPMMAGPVLTAIAIGLISCTFldkalYIGVVFGSNVLF 373
Cdd:cd17475   21 FLQEDLHLSLAQVGLLlSALNLGVAVSMLPAGW-LLDRFGERRVLAVGLLLMGAAALLMALVG-----SYPVLLVLLFLV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 374 GLGLGCyATPSTDTAVANA-PENKIGVASGIYKMGSSLGGAMGIavtaslfALFLPLGMAHAAQYALWFNAALCLGAMAV 452
Cdd:cd17475   95 GAGYGS-VQPGGGRAIMRWfPPRERGLAMGIRQTGVPLGGALAA-------ALLPPLALHYGWRAAFVVAGLVSILAAVL 166


                 ....*
gi 556281318 453 SALLL 457
Cdd:cd17475  167 FWLFY 171
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 51-176 4.54e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 42.26  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  51 ETLTLAVSLSALFSGcfvVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLS---AACIMPATLA 127
Cdd:cd17360   38 ELIVSSTVAGAAVGA---AIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvgiASMTVPLYIA 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 556281318 128 LIKTwyqGRARQRAVSFWVIGSWGGSGLCSFVGGAIA-TGLGWRWIFVFS 176
Cdd:cd17360  115 EAAP---PRIRGRLVTINVLFITGGQFVAYVINGAFSyLPGGWRWMLGLA 161
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 23-178 6.56e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.82  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  23 LSVLTFWLFAQSV-INVVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFG-RMRMTTLGLGLSIVGSAMLVL 100
Cdd:cd17490    2 LIIVFLFWFSQYVyVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMIL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556281318 101 AQGPGLFLAGRVLQGLSAACIMPATLaLIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFVFSIA 178
Cdd:cd17490   82 FPSPWGLLIARFLSGIAAATWVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAAL 158
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 21-175 7.48e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.77  E-value: 7.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  21 IVLSVLTFWLFAQSVIN--VVPAMKSSLDISLETLTLAvsLSALFSGCFV--VASGGLADKFGRMRMTTLGLGLSIVGSA 96
Cdd:cd17380    2 ILLFLATCICYADRVNMpiAIVPMAKEFGWSKTDQGLV--LSSFFWGYALtqVLGGYLADRFGGKKVLLLAVALWSLATL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  97 M--LVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGLGWRWIFV 174
Cdd:cd17380   80 LtpLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159


                 .
gi 556281318 175 F 175
Cdd:cd17380  160 F 160
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 59-176 2.06e-03

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 40.50  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318   59 LSALFSGCFV--VASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPG--LFLAGRVLQGLSAACIMPATLALIKTWYQ 134
Cdd:TIGR00894  82 LSSHFYGQIIiqIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGiaLVVFCRVIQGLAQGSVSPATHKIIVKWAP 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 556281318  135 GRARQRA-----------------VSFWVIGSWGGSGLCSFVGGAIATGLGWRWiFVFS 176
Cdd:TIGR00894 162 PKERSRLlgmstsgfqlgtfiflpISGWLCESWGGWPMIFYVFGIVGCAWSLLW-FVFP 219
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 62-149 2.33e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 40.29  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  62 LFSGCFVVasGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRA 141
Cdd:cd17438   47 MMAGAFIW--GGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124

                         90
                 ....*....|..
gi 556281318 142 VS----FWVIGS 149
Cdd:cd17438  125 LSwlcmFWMIGG 136
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 34-194 3.87e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.48  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  34 SVIN-VVPAMKSSLDISLETLTLAVSLSALFSGCFV--VASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAG 110
Cdd:cd17315   14 GVINgALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIgsLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 111 RVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIATGL--GWRWIFVFSIAVALAALALLR 188
Cdd:cd17315   94 RFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALLQLLLMF 173


                 ....*.
gi 556281318 189 GTPESR 194
Cdd:cd17315  174 FLPESR 179
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 44-179 4.84e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 4.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  44 SSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAAC--- 120
Cdd:cd17370  227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAqes 306

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556281318 121 IMPATLALIKtwyqgRARQRAVSFWVIGSwgGSGLCSFVGGAIA----TGLGWRWIFVFSIAV 179
Cdd:cd17370  307 IERAAVADLV-----PAELRGTAYGLFNT--VVGIGWLLASLIAgylwDLISPSAAFLFSAVL 362
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
72-173 5.02e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 39.13  E-value: 5.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  72 GGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLALIKTWYQGRARQRAVSFWVIGSWG 151
Cdd:PRK11102  47 GPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTI 126

                         90       100
                 ....*....|....*....|..
gi 556281318 152 GSGLCSFVGGAIATGLGWRWIF 173
Cdd:PRK11102 127 APLLAPIIGGWLLVWFSWHAIF 148
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 38-223 5.67e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 5.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  38 VVPAMKSSLDISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLS 117
Cdd:cd17478   18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 118 AACIMPATLALIkTWYQGRARQRAVSFWVIGSWGGSGLCSFVGGAIAT---GLGWRWIFVFSIAVALAALALLRGTPESR 194
Cdd:cd17478   98 SAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAlfgGLGLLILLIIPGLAVALLLLRLRPLKKPE 176

                        170       180
                 ....*....|....*....|....*....
gi 556281318 195 SASASQQKLDVGGLLSLIAGLVLVNLFIS 223
Cdd:cd17478  177 AKKAAAKSSARSTLKGVWRALLLLLIIVF 205
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 48-129 7.40e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.36  E-value: 7.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318  48 ISLETLTLAVSLSALFSGCFVVASGGLADKFGRMRMTTLGLGLSIVGSAMLVLAQGPGLFLAGRVLQGLSAACIMPATLA 127
Cdd:cd17329   32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111


                 ..
gi 556281318 128 LI 129
Cdd:cd17329  112 MI 113
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 280-424 8.92e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.36  E-value: 8.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556281318 280 FLLNGAIGTMMIASI---W------LQQGHHLTPLESGMMTLGYLVTVLAMIRVGEKLLQRYGARLPMMAGPVLTAIAIG 350
Cdd:cd17353    4 LVLLGAVLMHLILGYqyaWsvfnppLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556281318 351 LISCTfldkALYIGVVFGSNVLFGLGLG-CYATPsTDTAVANAPENKiGVASGIYKMGSSLGGAMGIAVTASLFA 424
Cdd:cd17353   84 LSAFA----ISLPLLFLGYGVLGGIGAGiGYITP-VSTAVKWFPDKR-GLATGIVIAGFGLGSLIFSPLIAYLIN 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH