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Conserved domains on  [gi|553758017|ref|WP_023090628|]
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hypothetical protein [Pseudomonas aeruginosa]

Protein Classification

Vgb family protein( domain architecture ID 11468173)

Vgb family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
37-281 1.83e-17

Streptogramin lyase [Defense mechanisms];


:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 80.83  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  37 TSIVLPAGARYPNGIAHAADGTLYVGLVTSGRILRK-PPGGEWETFFAGSLAifAATALRLDePRGLLWgnspdflpAGR 115
Cdd:COG4257    8 TEYPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLdPATGEFTEYPLGGGS--GPHGIAVD-PDGNLW--------FTD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 116 RRPHGVFALDLATGAVRRYlTLPGDGMG-NDLAVAPDGTVYLSETRDGSLMRLRPGEPAFQVLlrdsrLAGPGGLGAAGI 194
Cdd:COG4257   77 NGNNRIGRIDPKTGEITTF-ALPGGGSNpHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEF-----PLPTGGAGPYGI 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 195 VRVDDDTLLVGNFGSGAIHVVEgvASRPRLREMELPRTLENPDGMALAPDGSLIVLENA------IRSGAGKVLRIAEPL 268
Cdd:COG4257  151 AVDPDGNLWVTDFGANAIGRID--PDTGTLTEYALPTPGAGPRGLAVDPDGNLWVADTGsgrigrFDPKTGTVTEYPLPG 228

                        250
                 ....*....|....
gi 553758017 269 APGR-RGIEVIRDG 281
Cdd:COG4257  229 GGARpYGVAVDGDG 242
 
Name Accession Description Interval E-value
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
37-281 1.83e-17

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 80.83  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  37 TSIVLPAGARYPNGIAHAADGTLYVGLVTSGRILRK-PPGGEWETFFAGSLAifAATALRLDePRGLLWgnspdflpAGR 115
Cdd:COG4257    8 TEYPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLdPATGEFTEYPLGGGS--GPHGIAVD-PDGNLW--------FTD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 116 RRPHGVFALDLATGAVRRYlTLPGDGMG-NDLAVAPDGTVYLSETRDGSLMRLRPGEPAFQVLlrdsrLAGPGGLGAAGI 194
Cdd:COG4257   77 NGNNRIGRIDPKTGEITTF-ALPGGGSNpHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEF-----PLPTGGAGPYGI 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 195 VRVDDDTLLVGNFGSGAIHVVEgvASRPRLREMELPRTLENPDGMALAPDGSLIVLENA------IRSGAGKVLRIAEPL 268
Cdd:COG4257  151 AVDPDGNLWVTDFGANAIGRID--PDTGTLTEYALPTPGAGPRGLAVDPDGNLWVADTGsgrigrFDPKTGTVTEYPLPG 228

                        250
                 ....*....|....
gi 553758017 269 APGR-RGIEVIRDG 281
Cdd:COG4257  229 GGARpYGVAVDGDG 242
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 39-300 3.60e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.59  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  39 IVLP-AGARYPNGIAHAADGTLYVGLVTSGRILRKPpggewetffAGSlaifaatalrldeprgllwgNSPDFLP-AGRR 116
Cdd:cd14952    2 TVLPfTGLDGPGGVAVDAAGNVYVADSGNNRVLKLA---------AGS--------------------TTQTVLPfTGLY 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 117 RPHGVfALDlATGAV-------RRYL----------TLPGDGMGN--DLAVAPDGTVYLSETRDGSLMRLRPGEPAFQVL 177
Cdd:cd14952   53 QPQGV-AVD-AAGTVyvtdfgnNRVLklaagsttqtVLPFTGLNDptGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVL 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 178 ----LRDSRLagpgglgaagiVRVDD-DTLLVGNFGSGAIHVVEGVASRPRlremELPRT-LENPDGMALAPDGSLIVLE 251
Cdd:cd14952  131 pftgLSNPDG-----------VAVDGaGNVYVTDTGNNRVLKLAAGSTTQT----VLPFTgLNSPSGVAVDTAGNVYVTD 195

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 553758017 252 nairSGAGKVLRiaepLAPGRRGIEVIR-DGLESPVNLTVTGQGCAYVSE 300
Cdd:cd14952  196 ----HGNNRVLK----LAAGSTTPTVLPfTGLNGPLGVAVDAAGNVYVAD 237
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 51-265 1.78e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 42.25  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017   51 IAHAADGTLYVGLvTSGRILRKPPGGEWETFFAGSLAifAATALRLDE----PRGLLWGNSPDFLPAGRRRPHGVFALDL 126
Cdd:pfam08450  46 IAPRDDGGLIVAL-KDGVALLDLATGELTPLADPEDD--DWPLNRFNDgkvdPDGRFWFGTMGDDEAPGGDPGALYRLDP 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  127 ATGAVRryltlPGDGMG--NDLAVAPDG-TVYLSETRDGSLMrlrpgepAFqvllrdsrlagpgglgaagivRVDDDTLL 203
Cdd:pfam08450 123 DGKLTR-----VLDGLTisNGLAWSPDGrTLYFADSPARKIW-------AY---------------------DYDLDGGL 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 553758017  204 VGNfgsgaihvvegvasRPRLREMelPRTLENPDGMALAPDGSLIVlenaIRSGAGKVLRIA 265
Cdd:pfam08450 170 ISN--------------RRVFADF--KPGLGRPDGMAVDAEGNVWV----ARWGGGKVVRFD 211
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 235-299 2.84e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 42.26  E-value: 2.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 235 NPDGMALAPDGSLIVLENA-----IRSGAGKVLRIAeplAPGRRgiEVIRDGLESPVNLTVTGQGCAYVS 299
Cdd:NF033206 251 GLTDLAFDPDGNLYVLELAgggllKGDPTGSLIRIA---PDGTR--TTLLDGLELPTGLAVGPDGTLYVT 315
 
Name Accession Description Interval E-value
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
37-281 1.83e-17

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 80.83  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  37 TSIVLPAGARYPNGIAHAADGTLYVGLVTSGRILRK-PPGGEWETFFAGSLAifAATALRLDePRGLLWgnspdflpAGR 115
Cdd:COG4257    8 TEYPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLdPATGEFTEYPLGGGS--GPHGIAVD-PDGNLW--------FTD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 116 RRPHGVFALDLATGAVRRYlTLPGDGMG-NDLAVAPDGTVYLSETRDGSLMRLRPGEPAFQVLlrdsrLAGPGGLGAAGI 194
Cdd:COG4257   77 NGNNRIGRIDPKTGEITTF-ALPGGGSNpHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEF-----PLPTGGAGPYGI 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 195 VRVDDDTLLVGNFGSGAIHVVEgvASRPRLREMELPRTLENPDGMALAPDGSLIVLENA------IRSGAGKVLRIAEPL 268
Cdd:COG4257  151 AVDPDGNLWVTDFGANAIGRID--PDTGTLTEYALPTPGAGPRGLAVDPDGNLWVADTGsgrigrFDPKTGTVTEYPLPG 228

                        250
                 ....*....|....
gi 553758017 269 APGR-RGIEVIRDG 281
Cdd:COG4257  229 GGARpYGVAVDGDG 242
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 40-330 1.05e-16

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 78.40  E-value: 1.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  40 VLPAGARYPNGIAHAADGTLYVGLVTSGRILR-KPPGGEWETFFAGSLaifAATALRLDEPRGLLwgnspdflpAGRRRp 118
Cdd:COG3386    2 LADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRyDPDGGAVEVFAEPSG---RPNGLAFDPDGRLL---------VADHG- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 119 HGVFALDLATGAVRRYLTLPGDGMG--NDLAVAPDGTVYLS----ETRDGSLMRLRPGEpAFQVLLRDsrlagpgglgaa 192
Cdd:COG3386   69 RGLVRFDPADGEVTVLADEYGKPLNrpNDGVVDPDGRLYFTdmgeYLPTGALYRVDPDG-SLRVLADG------------ 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 193 gIVRV-------DDDTLLVGNFGSGAIHVVE----GVASRPRLrEMELPRTLENPDGMALAPDGSLIVLENairsGAGKV 261
Cdd:COG3386  136 -LTFPngiafspDGRTLYVADTGAGRIYRFDldadGTLGNRRV-FADLPDGPGGPDGLAVDADGNLWVALW----GGGGV 209

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 553758017 262 LRIaeplAPGRRGIEVIRDGLESPVNLTVTGQGC--AYVSESRirhrllpgregEVPARFLIHRLPLDAAG 330
Cdd:COG3386  210 VRF----DPDGELLGRIELPERRPTNVAFGGPDLrtLYVTTAR-----------SLPLAGALFRVRVDVPG 265
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
37-169 2.02e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.42  E-value: 2.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  37 TSIVLPAGARYPNGIAHAADGTLYVGLVTSGRILR-KPPGGEWETFFAGSLAIFAaTALRLDePRGLLW----------- 104
Cdd:COG4257   93 TTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRlDPATGEVTEFPLPTGGAGP-YGIAVD-PDGNLWvtdfganaigr 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 105 -----GNSPDF-LPAGRRRPHGVFA------------------LDLATGAVRRYLTLPGDGMGNDLAVAPDGTVYLSETR 160
Cdd:COG4257  171 idpdtGTLTEYaLPTPGAGPRGLAVdpdgnlwvadtgsgrigrFDPKTGTVTEYPLPGGGARPYGVAVDGDGRVWFAESG 250


                 ....*....
gi 553758017 161 DGSLMRLRP 169
Cdd:COG4257  251 ANRIVRFDP 259
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
49-210 2.19e-06

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 49.22  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  49 NGIAHAADGTLYV----GLVTSGRILRKPPGGEWETFFAGSLAIFAATALRLDePRGLLWGNSPDflpagrrrpHGVFAL 124
Cdd:COG3292  270 RSIAEDSDGNLWIrlwiGTYGGGLFRLDPKTGKFKRYNPNGLPSNSVYSILED-SDGNLWIGTSG---------GGLYRY 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 125 DLATGAVRRYLTLPG--DGMGNDLAVAPDGTVYLSeTRDGsLMRLRPGEPAFQVLLRDSRLAGPGGLGAAGIVRVDDDTL 202
Cdd:COG3292  340 DPKTGKFTKFSEDNGlsNNFIRSILEDSDGNLWVG-TNGG-LYRLDPKTGKFTNFTHDPDKNGLSSNYINSIFEDSDGRL 417


                 ....*...
gi 553758017 203 LVGNFGSG 210
Cdd:COG3292  418 WIGTDGGG 425
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 39-300 3.60e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.59  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  39 IVLP-AGARYPNGIAHAADGTLYVGLVTSGRILRKPpggewetffAGSlaifaatalrldeprgllwgNSPDFLP-AGRR 116
Cdd:cd14952    2 TVLPfTGLDGPGGVAVDAAGNVYVADSGNNRVLKLA---------AGS--------------------TTQTVLPfTGLY 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 117 RPHGVfALDlATGAV-------RRYL----------TLPGDGMGN--DLAVAPDGTVYLSETRDGSLMRLRPGEPAFQVL 177
Cdd:cd14952   53 QPQGV-AVD-AAGTVyvtdfgnNRVLklaagsttqtVLPFTGLNDptGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVL 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 178 ----LRDSRLagpgglgaagiVRVDD-DTLLVGNFGSGAIHVVEGVASRPRlremELPRT-LENPDGMALAPDGSLIVLE 251
Cdd:cd14952  131 pftgLSNPDG-----------VAVDGaGNVYVTDTGNNRVLKLAAGSTTQT----VLPFTgLNSPSGVAVDTAGNVYVTD 195

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 553758017 252 nairSGAGKVLRiaepLAPGRRGIEVIR-DGLESPVNLTVTGQGCAYVSE 300
Cdd:cd14952  196 ----HGNNRVLK----LAAGSTTPTVLPfTGLNGPLGVAVDAAGNVYVAD 237
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 42-306 1.05e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.16  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  42 PAGARYPNGIAHAADGTLYVGLVTSGRILRKPPGGEwetfFAGSLAIFAATALRLDEPRGLlwgnspDFLPAGRrrphgV 121
Cdd:cd05819    4 PGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGN----FITSFGSFGSGDGQFNEPAGV------AVDSDGN-----L 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 122 FALDLATGAVRRY---------LTLPGDGMGN-----DLAVAPDGTVYLSETRDGSlmrlrpgepafqvllrdsrlagpg 187
Cdd:cd05819   69 YVADTGNHRIQKFdpdgnflasFGGSGDGDGEfngprGIAVDSSGNIYVADTGNHR------------------------ 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 188 glgaagIVRVDDDTLLVGNFGSGAihvvegvasrprlremELPRTLENPDGMALAPDGSLIVLEnairSGAGKVLRIA-- 265
Cdd:cd05819  125 ------IQKFDPDGEFLTTFGSGG----------------SGPGQFNGPTGVAVDSDGNIYVAD----TGNHRIQVFDpd 178

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 553758017 266 -EPLAP-GRRGIEVIRdgLESPVNLTVTGQGCAYVSESRiRHR 306
Cdd:cd05819  179 gNFLTTfGSTGTGPGQ--FNYPTGIAVDSDGNIYVADSG-NNR 218
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 46-303 1.28e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.13  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  46 RYPNGIAHAADGTLYVGLVTSGRILRKPPGGEWETFFAGS---LAIFAATALRLDEprgllwGNspdfLPAGRRRPHGVF 122
Cdd:cd14963   56 KYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYFPEKkdrVKLISPAGLAIDD------GK----LYVSDVKKHKVI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 123 ALDLaTGAVRRYLTLPGDGMG-----NDLAVAPDGTVYLSETRDGSLmrlrpgepafQVLLRDsrlagpgglgaagivrv 197
Cdd:cd14963  126 VFDL-EGKLLLEFGKPGSEPGelsypNGIAVDEDGNIYVADSGNGRI----------QVFDKN----------------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 198 dddtllvGNFgsgaihvVEGVASRPrlremELPRTLENPDGMALAPDGSLIVLEN-----AIRSGAGKVLRIAeplapGR 272
Cdd:cd14963  178 -------GKF-------IKELNGSP-----DGKSGFVNPRGIAVDPDGNLYVVDNlshrvYVFDEQGKELFTF-----GG 233

                        250       260       270
                 ....*....|....*....|....*....|....
gi 553758017 273 RGIEviRDGLESPVNLTVTGQGCAYVSE---SRI 303
Cdd:cd14963  234 RGKD--DGQFNLPNGLFIDDDGRLYVTDrenNRV 265
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
51-181 1.51e-04

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 43.44  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  51 IAHAADGTLYVGLVTSGRILRKPPGGEWETF-FAGSLAIFAATALRLDePRGLLWgnspdflpAGRRrpHGVFALDLATG 129
Cdd:COG3292  319 ILEDSDGNLWIGTSGGGLYRYDPKTGKFTKFsEDNGLSNNFIRSILED-SDGNLW--------VGTN--GGLYRLDPKTG 387

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 553758017 130 AVRRYLTLPGDGMG-----NDLAVAPDGTVYLSeTRDGSLMRLRPGEPAFQVLLRDS 181
Cdd:COG3292  388 KFTNFTHDPDKNGLssnyiNSIFEDSDGRLWIG-TDGGGLYRYDPKTGKFKHFTTKD 443
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
55-248 1.62e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  55 ADGTLYVGLVTSGRILRKPPGGEWETFFAGSLAIFAATALRLDEPRGLLWGNSPDFLPAGRRRPHGVFALDLATGAVRRY 134
Cdd:COG3391   26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVAT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 135 LTLPGDGMGndLAVAPDG-TVYLSETRDGSLMRLRPgePAFQVLlrdsRLAGPGGLGAAGIVRVDDDTLLVGNFGSGAIH 213
Cdd:COG3391  106 IPVGGGPRG--LAVDPDGgRLYVADSGNGRVSVIDT--ATGKVV----ATIPVGAGPHGIAVDPDGKRLYVANSGSNTVS 177

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 553758017 214 VVEGVASRPRLREMELPRTLENPDGMALAPDGSLI 248
Cdd:COG3391  178 VIVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRL 212
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 51-265 1.78e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 42.25  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017   51 IAHAADGTLYVGLvTSGRILRKPPGGEWETFFAGSLAifAATALRLDE----PRGLLWGNSPDFLPAGRRRPHGVFALDL 126
Cdd:pfam08450  46 IAPRDDGGLIVAL-KDGVALLDLATGELTPLADPEDD--DWPLNRFNDgkvdPDGRFWFGTMGDDEAPGGDPGALYRLDP 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  127 ATGAVRryltlPGDGMG--NDLAVAPDG-TVYLSETRDGSLMrlrpgepAFqvllrdsrlagpgglgaagivRVDDDTLL 203
Cdd:pfam08450 123 DGKLTR-----VLDGLTisNGLAWSPDGrTLYFADSPARKIW-------AY---------------------DYDLDGGL 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 553758017  204 VGNfgsgaihvvegvasRPRLREMelPRTLENPDGMALAPDGSLIVlenaIRSGAGKVLRIA 265
Cdd:pfam08450 170 ISN--------------RRVFADF--KPGLGRPDGMAVDAEGNVWV----ARWGGGKVVRFD 211
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 47-304 2.66e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.92  E-value: 2.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  47 YPNGIAHAADGTLYVGLVTSGRILRKPPGGEWETFFAGslaiFAATALRLDEPRGLlwgnspDFLPAGR-----RRPHGV 121
Cdd:cd05819   56 EPAGVAVDSDGNLYVADTGNHRIQKFDPDGNFLASFGG----SGDGDGEFNGPRGI------AVDSSGNiyvadTGNHRI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 122 FALDLATGAVRrylTLPGDGMGN-------DLAVAPDGTVYLSETRDGSlmrlrpgepafqvllrdsrlagpgglgaagI 194
Cdd:cd05819  126 QKFDPDGEFLT---TFGSGGSGPgqfngptGVAVDSDGNIYVADTGNHR------------------------------I 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 195 VRVDDDTLLVGNFGSGAIHvvegvasrprlremelPRTLENPDGMALAPDGSLIVLEnairSGAGKVLRI-AEPLAPGRR 273
Cdd:cd05819  173 QVFDPDGNFLTTFGSTGTG----------------PGQFNYPTGIAVDSDGNIYVAD----SGNNRVQVFdPDGAGFGGN 232

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 553758017 274 G-IEVIRDGLESPVNLTVTGQGCAYVSES---RIR 304
Cdd:cd05819  233 GnFLGSDGQFNRPSGLAVDSDGNLYVADTgnnRIQ 267
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 235-299 2.84e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 42.26  E-value: 2.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 235 NPDGMALAPDGSLIVLENA-----IRSGAGKVLRIAeplAPGRRgiEVIRDGLESPVNLTVTGQGCAYVS 299
Cdd:NF033206 251 GLTDLAFDPDGNLYVLELAgggllKGDPTGSLIRIA---PDGTR--TTLLDGLELPTGLAVGPDGTLYVT 315
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
127-300 6.50e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.77  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 127 ATGAVRRYlTLPGDGMG-NDLAVAPDGTVYLSETRDGSLMRLRPGEPAFqvllrdsRLAGPGGLGAAGIVRVDDD-TLLV 204
Cdd:COG4257    3 SAVDITEY-PVPAPGSGpRDVAVDPDGAVWFTDQGGGRIGRLDPATGEF-------TEYPLGGGSGPHGIAVDPDgNLWF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017 205 GNFGSGAIHVVEGVASrpRLREMELPRTLENPDGMALAPDGSLIVLENairsGAGKVLRIaeplAPGRRGIEVIRDGLE- 283
Cdd:COG4257   75 TDNGNNRIGRIDPKTG--EITTFALPGGGSNPHGIAFDPDGNLWFTDQ----GGNRIGRL----DPATGEVTEFPLPTGg 144

                        170
                 ....*....|....*...
gi 553758017 284 -SPVNLTVTGQGCAYVSE 300
Cdd:COG4257  145 aGPYGIAVDPDGNLWVTD 162
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 42-159 3.81e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 38.45  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553758017  42 PAGARYPNGIAHAADGTLYVGLVTSGRILRKPPGGEWETFFAGSlaifAATALRLDEPRGLlwgnspDFLPAGRrrphgV 121
Cdd:cd05819  145 PGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGST----GTGPGQFNYPTGI------AVDSDGN-----I 209

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 553758017 122 FALDLATGAVRRY--LTLPGDGMGN------------DLAVAPDGTVYLSET 159
Cdd:cd05819  210 YVADSGNNRVQVFdpDGAGFGGNGNflgsdgqfnrpsGLAVDSDGNLYVADT 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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