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Conserved domains on  [gi|550766046|ref|WP_022649406|]
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MULTISPECIES: 1-acylglycerol-3-phosphate O-acyltransferase [Enterobacter]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 1-245 1.43e-164

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member PRK15018:

Pssm-ID: 473073  Cd Length: 245  Bit Score: 454.47  E-value: 1.43e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   1 MLYIVRLILTVIYCILVCIFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVEKRLPEGAENFGNAIYIANHQNNYDMV 80
Cdd:PRK15018   1 MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  81 TASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRISIWMFPEGTRSRGRGLLPFK 160
Cdd:PRK15018  81 TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 161 TGAFHAAIAAGVPIIPVCVSNTSNKINLNRLKNGLVIVEMLPPVDTSKYGKDQVRELATHCRELMAQHIAQLDKEVAERE 240
Cdd:PRK15018 161 TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE 240


                 ....*
gi 550766046 241 AAGKI 245
Cdd:PRK15018 241 AAGKV 245
 
Name Accession Description Interval E-value
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 1-245 1.43e-164

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 454.47  E-value: 1.43e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   1 MLYIVRLILTVIYCILVCIFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVEKRLPEGAENFGNAIYIANHQNNYDMV 80
Cdd:PRK15018   1 MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  81 TASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRISIWMFPEGTRSRGRGLLPFK 160
Cdd:PRK15018  81 TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 161 TGAFHAAIAAGVPIIPVCVSNTSNKINLNRLKNGLVIVEMLPPVDTSKYGKDQVRELATHCRELMAQHIAQLDKEVAERE 240
Cdd:PRK15018 161 TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE 240


                 ....*
gi 550766046 241 AAGKI 245
Cdd:PRK15018 241 AAGKV 245
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 50-180 1.75e-60

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 186.78  E-value: 1.75e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   50 GLKVEKRLPEGAENFGNAIYIANHQNNYDMVTASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRaKAHGTIA 129
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENI-RAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 550766046  130 EVVDQFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 32-237 2.02e-58

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 184.44  E-value: 2.02e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  32 PKHVATFGHMFGRLA-PLFGLKVEkrlPEGAENF---GNAIYIANHQNNYDMVTASNIVIPPTVTVGKKSLLWIPLFGQL 107
Cdd:COG0204    9 RRFRYRLVRLWARLLlRLLGVRVR---VEGLENLpadGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 108 YWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKI- 186
Cdd:COG0204   86 LRALGAIPVDRSKRRAALRALRQAVEALKAGE-SLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALp 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550766046 187 NLNRLKNGLVIVEMLPPVDTSKYGKDQVRELATHCRELMAQHIAQLDKEVA 237
Cdd:COG0204  165 KGFLPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 44-222 3.89e-43

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 144.34  E-value: 3.89e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  44 RLAPLFGLKVEKrlpEGAENF---GNAIYIANHQNNYDMVTASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNN 120
Cdd:cd07989    3 LLLRLLGVRVRV---EGLENLppkGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 121 RAKAHGTIAEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT--SNKINLNRLKNGLVIV 198
Cdd:cd07989   80 GRSAREALREAIEALKEGE-SVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTwgSLPKGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*.
gi 550766046 199 EMLPPVDTSKYGKDQ--VRELATHCR 222
Cdd:cd07989  159 RIGEPIPPEGLELAEedRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 52-180 1.88e-40

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 135.48  E-value: 1.88e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   52 KVEKRLPEGAENFGNAIYIANHQNNYDMVTASNIV---IPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTI 128
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALykrGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 550766046  129 AEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:pfam01553  81 EYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 67-182 6.71e-34

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 118.23  E-value: 6.71e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046    67 AIYIANHQNNYDMVTASNIV---IPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRiSIW 143
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLprkLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGE-WLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 550766046   144 MFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT 182
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
 
Name Accession Description Interval E-value
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 1-245 1.43e-164

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 454.47  E-value: 1.43e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   1 MLYIVRLILTVIYCILVCIFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVEKRLPEGAENFGNAIYIANHQNNYDMV 80
Cdd:PRK15018   1 MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  81 TASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRISIWMFPEGTRSRGRGLLPFK 160
Cdd:PRK15018  81 TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 161 TGAFHAAIAAGVPIIPVCVSNTSNKINLNRLKNGLVIVEMLPPVDTSKYGKDQVRELATHCRELMAQHIAQLDKEVAERE 240
Cdd:PRK15018 161 TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE 240


                 ....*
gi 550766046 241 AAGKI 245
Cdd:PRK15018 241 AAGKV 245
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 50-180 1.75e-60

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 186.78  E-value: 1.75e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   50 GLKVEKRLPEGAENFGNAIYIANHQNNYDMVTASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRaKAHGTIA 129
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENI-RAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 550766046  130 EVVDQFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 32-237 2.02e-58

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 184.44  E-value: 2.02e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  32 PKHVATFGHMFGRLA-PLFGLKVEkrlPEGAENF---GNAIYIANHQNNYDMVTASNIVIPPTVTVGKKSLLWIPLFGQL 107
Cdd:COG0204    9 RRFRYRLVRLWARLLlRLLGVRVR---VEGLENLpadGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 108 YWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKI- 186
Cdd:COG0204   86 LRALGAIPVDRSKRRAALRALRQAVEALKAGE-SLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALp 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550766046 187 NLNRLKNGLVIVEMLPPVDTSKYGKDQVRELATHCRELMAQHIAQLDKEVA 237
Cdd:COG0204  165 KGFLPRPGKVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRAEAA 215
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 44-222 3.89e-43

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 144.34  E-value: 3.89e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  44 RLAPLFGLKVEKrlpEGAENF---GNAIYIANHQNNYDMVTASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNN 120
Cdd:cd07989    3 LLLRLLGVRVRV---EGLENLppkGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 121 RAKAHGTIAEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT--SNKINLNRLKNGLVIV 198
Cdd:cd07989   80 GRSAREALREAIEALKEGE-SVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTwgSLPKGKKLPRPGRVTV 158

                        170       180
                 ....*....|....*....|....*.
gi 550766046 199 EMLPPVDTSKYGKDQ--VRELATHCR 222
Cdd:cd07989  159 RIGEPIPPEGLELAEedRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 52-180 1.88e-40

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 135.48  E-value: 1.88e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046   52 KVEKRLPEGAENFGNAIYIANHQNNYDMVTASNIV---IPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTI 128
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALykrGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 550766046  129 AEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS 180
Cdd:pfam01553  81 EYLVELLREGK-LVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 67-182 6.71e-34

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 118.23  E-value: 6.71e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046    67 AIYIANHQNNYDMVTASNIV---IPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGTIAEVVDQFKKRRiSIW 143
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLprkLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGE-WLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 550766046   144 MFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNT 182
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 59-229 4.91e-19

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 82.27  E-value: 4.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  59 EGAENFGNA--IYIANHQNNYDMVTASnIVIPPTVtVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHGT---IAEVVD 133
Cdd:cd07991   16 HGKPDPPEAprIIVANHTSFIDPLILF-SDLFPSI-VAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVveeIKERAT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 134 QFKKRRISIwmFPEGTRSRGRGLLPFKTGAFhaaiAAGVPIIPVCV--SNTSNKINLNRLKNGL--------------VI 197
Cdd:cd07991   94 DPNWPPILI--FPEGTTTNGKALIMFKKGAF----EPGVPVQPVAIryPNKFVDAFWNSSGYSSlmylfrlltqpanvLE 167

                        170       180       190
                 ....*....|....*....|....*....|..
gi 550766046 198 VEMLPPVDTSKYGKDQvRELATHCRELMAQHI 229
Cdd:cd07991  168 VEFLPVYTPSEEGEDP-KEFANRVRLIMANKL 198
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 50-226 7.16e-17

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 75.91  E-value: 7.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  50 GLKVEKRLPEGAENFGNAIYIANHQNNYDM-----VTASNIVIPPTVTVGKKSLLWIPLFGQLywltGNLLIDRNNRAKA 124
Cdd:cd06551   11 FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGlilflLLERGLRRDVYGLMDEELLERYPFFTRL----GAFSVDRDSPRSA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 125 HGTIAEVVDQFKKRRISIWMFPEGTRSRGR-GLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKInLNRLKNGLVIVEMLPP 203
Cdd:cd06551   87 AKSLKYVARLLSKPGSVVWIFPEGTRTRRDkRPLQFKPGVAHLAEKAGVPIVPVALRYTFELF-EQFPEIFVRIGPPIPY 165

                        170       180
                 ....*....|....*....|...
gi 550766046 204 VDTSKYGKDQvRELATHCRELMA 226
Cdd:cd06551  166 AETALGEELA-AELANRLTRLLD 187
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 48-177 2.05e-15

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 71.48  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  48 LFGLKVEKRLPEGAENfgnAIYIANHQNNYD----MVTASNIVIPPTVtVGKKSLLWIPLFGQLYWLtGNLLIDRNNRAk 123
Cdd:cd07988    7 LSGWRIEGEPPNKPKF---VVIGAPHTSNWDfvlgLLAAFALGLKISF-LGKHSLFKPPLGPFMRWL-GGIPVDRSRAG- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 550766046 124 ahGTIAEVVDQFKKR-RISIWMFPEGTRSRGRgllPFKTGAFHAAIAAGVPIIPV 177
Cdd:cd07988   81 --GLVEQVVEEFRRReEFVLAIAPEGTRSKVD---KWKTGFYHIARGAGVPILLV 130
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 46-208 4.81e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 68.60  E-value: 4.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  46 APLFGLKVEKR--LPEGAENfgnAIYIANHQNNYDMVTASNIVIPPTVtVGKKSLLWIPLFGQLYWLTGNLLIDRNNRAK 123
Cdd:PLN02901  32 SPFYKIEVEGLenLPSPDEP---AVYVSNHQSFLDIYTLFHLGRPFKF-ISKTSIFLIPIIGWAMYMTGHIPLKRMDRRS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 124 AHGTIAEVVDQFKKRrISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSNTSNKINLNR---LKNGLVIVEM 200
Cdd:PLN02901 108 QLECLKRCMELLKKG-ASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGTGKIMPNGKegiLNPGSVKVVI 186


                 ....*...
gi 550766046 201 LPPVDTSK 208
Cdd:PLN02901 187 HPPIEGSD 194
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 48-168 2.26e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 66.49  E-value: 2.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  48 LFGLKVE---KRLPEGAENfgnAIYIANHQNNYD-----MVTASNIVIPPTVTVGKKSLLWIPLFGQLYWLTGNLLIDRN 119
Cdd:cd07990    7 LSGVKVVvygDEPKLPKER---ALIISNHRSEVDwlvlwMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRK 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 120 NrAKAHGTIAEVVDQFKKRRISIWM--FPEGTR----SRGRG---------------LLPfKTGAFHAAI 168
Cdd:cd07990   84 W-EKDEKTIKRQLKRLKDSPEPFWLliFPEGTRfteeKKERSqefaeknglpplkhvLLP-RTKGFVAIL 151
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 59-177 3.28e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 46.49  E-value: 3.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046  59 EGAENF---GNAIYIANHQNNY-D-MVTASNIVIPPTVTVgKKSLLWIPLFGQLYWLTGNLLIDRNNRAKAHG------- 126
Cdd:cd07992   19 VGRENVpkdGPVIFLGNHPNALiDpLLLAATLRRPVRFLA-KADLFKNPLIGWLLESFGAIPVYRPKDLARGGigkisna 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 550766046 127 -TIAEVVDQFKKRRiSIWMFPEGTRSRGRGLLPFKTGAFHAAIAA------GVPIIPV 177
Cdd:cd07992   98 aVFDAVGEALKAGG-AIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVPV 154
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 101-180 2.20e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 44.10  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766046 101 IPLFGQLYWLTGNLLIDR----NNRAKAhgTIAEVVDQFKKRRISIWMFPEGTRSRGRGLLPFKTG-------AFHAAIA 169
Cdd:cd07993   61 IPILGTLLRRLGAFFIRRsfgkDPLYRA--VLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGllsvvveAYLKGSV 138

                         90
                 ....*....|.
gi 550766046 170 AGVPIIPVCVS 180
Cdd:cd07993  139 PDVLIVPVSIS 149
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 138-177 7.95e-04

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 40.29  E-value: 7.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 550766046 138 RRISIWMFPEGTRSR-GRgLLPFKTG-------AFHAAIAAGVPIIPV 177
Cdd:COG2937  281 RGYSVEYFIEGGRSRtGR-LLPPKTGmlsmtvqAFLRGARRPVVFVPV 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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