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Conserved domains on  [gi|550714308|ref|WP_022647197|]
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MULTISPECIES: lysophospholipid acyltransferase family protein [Enterobacter]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168417)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 54-257 7.50e-68

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


:

Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 218.66  E-value: 7.50e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  54 LEHLDILCTISARDLEQIPEHGPLIVIANHPTGTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLFIPVDNMGGRTA 133
Cdd:cd07986    1 LDALNVQLEVDVSGLENIPKDGPVVIVANHPFGILDGLILADLLGSVRPDVRILANQLLSKIPELRDLFIPVDPLEGRAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 134 ----KASLVQMEQHLQNAGVLIFFPAGEVSR--PTRKGIRDKKWHPGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSP 207
Cdd:cd07986   81 laknRESLREALRHLKNGGALIIFPAGRVSTasPPFGRVSDRPWNPFVARLARKAKAPVVPVYFSGRNSRLFYLAGLIHP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 550714308 208 TVSLLLLMQQMFRRRHSQLPIKIGQQIAWNDrFSSTLSSREMAEQCRQHV 257
Cdd:cd07986  161 TLRTLLLPRELLNKRGKTIRIRVGRPIPPEE-LARFEDAEELADFLRLHT 209
Acetyltransf_5 pfam13444
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 322-423 9.31e-31

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions.


:

Pssm-ID: 463880  Cd Length: 102  Bit Score: 115.40  E-value: 9.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  322 LREIAFRAVEEGSGK----RRDTDSYDDDYLHLILWDDDDLEIVGAYRFMPTAMQvekCGVEGLYSYSLFHyDEKMQDIL 397
Cdd:pfam13444   1 LRYRVFREEMGATGPaalpGLDIDRFDAYCDHLLVWDDDTGEVVGTYRLLPPDAA---SGLGGFYSATEFD-LSALLALR 76

                          90       100
                  ....*....|....*....|....*.
gi 550714308  398 EHGIELGRSFIQPRYWGRRGLDYLWS 423
Cdd:pfam13444  77 GRLLELGRSCVHPEYRNGRVLLLLWA 102
 
Name Accession Description Interval E-value
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 54-257 7.50e-68

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 218.66  E-value: 7.50e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  54 LEHLDILCTISARDLEQIPEHGPLIVIANHPTGTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLFIPVDNMGGRTA 133
Cdd:cd07986    1 LDALNVQLEVDVSGLENIPKDGPVVIVANHPFGILDGLILADLLGSVRPDVRILANQLLSKIPELRDLFIPVDPLEGRAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 134 ----KASLVQMEQHLQNAGVLIFFPAGEVSR--PTRKGIRDKKWHPGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSP 207
Cdd:cd07986   81 laknRESLREALRHLKNGGALIIFPAGRVSTasPPFGRVSDRPWNPFVARLARKAKAPVVPVYFSGRNSRLFYLAGLIHP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 550714308 208 TVSLLLLMQQMFRRRHSQLPIKIGQQIAWNDrFSSTLSSREMAEQCRQHV 257
Cdd:cd07986  161 TLRTLLLPRELLNKRGKTIRIRVGRPIPPEE-LARFEDAEELADFLRLHT 209
COG3176 COG3176
Putative hemolysin [General function prediction only];
19-263 5.05e-62

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 205.66  E-value: 5.05e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  19 PWQKSLLKRLLHEDEFQQFAASH----RHLKGLDMVEQVLEHLDILCTISARDLEQIPEHGPLIVIANHPTGTLDGLALL 94
Cdd:COG3176   11 RLLIRLLERLLGLGRLNRLYDQYartpAELRGAQFLRYVFEELGARLEVPEGDLDRIDADGHLLVVANHPLGILDGLALL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  95 YAVSRVRRDVKVVTNRMLSHLEP--LSSLFIPVDNMGGRTAKASLvqmeQHLQNAGVLIFFPAGEVSRptRKGIRDKKWH 172
Cdd:COG3176   91 KLVGTVRPDYRILANDLALRIPGgfYSELEFPVDPFNLETLKAAR----RHLLEGGRSCVFPAGRVSG--ARRVIDLLWS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 173 PGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSPTVSLLLLMQQMFRRRHSQLPIKIGQQIAWnDRFSSTLSSREMAEQ 252
Cdd:COG3176  165 GLAAKLARKAGAPVVPVYFDGRNSGLFYLFGSIHPTLRTAALPRELLRKRGHLIELRVGRPIPP-LELDLDLDPAELPPL 243

                        250
                 ....*....|.
gi 550714308 253 CRQHVIRLGKG 263
Cdd:COG3176  244 LRGYTYALGAD 254
Acetyltransf_5 pfam13444
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 322-423 9.31e-31

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions.


Pssm-ID: 463880  Cd Length: 102  Bit Score: 115.40  E-value: 9.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  322 LREIAFRAVEEGSGK----RRDTDSYDDDYLHLILWDDDDLEIVGAYRFMPTAMQvekCGVEGLYSYSLFHyDEKMQDIL 397
Cdd:pfam13444   1 LRYRVFREEMGATGPaalpGLDIDRFDAYCDHLLVWDDDTGEVVGTYRLLPPDAA---SGLGGFYSATEFD-LSALLALR 76

                          90       100
                  ....*....|....*....|....*.
gi 550714308  398 EHGIELGRSFIQPRYWGRRGLDYLWS 423
Cdd:pfam13444  77 GRLLELGRSCVHPEYRNGRVLLLLWA 102
Acyltransf_2 pfam19576
Acyltransferase; This family of proteins are likely to function as acyltransferases. Proteins ...
 25-255 2.42e-21

Acyltransferase; This family of proteins are likely to function as acyltransferases. Proteins in this family are found in Bacteria.


Pssm-ID: 437408  Cd Length: 266  Bit Score: 93.93  E-value: 2.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308   25 LKRLLHEDEFQQFAASHRHLKGLDMVEQVLEHLDIlcTISARDLEQIPEHGPLIVIANHPTGTLDGLALLYAVSRVRRDV 104
Cdd:pfam19576  22 LRRTIHEEDINHILANFWELPPQEFIHACFREWGI--TYSSEGLDRLDPAGRYLFVSNHPFGGMDGMMLADELIDRFGDA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  105 KVVTNRMLSHLEPLSSLFIPVDNMGGRTAkASLVQMEQHLQNAGVLIFFPAGEVSRPTRKGIRDKKWHPGFIKLASKLRV 184
Cdd:pfam19576 100 RVVVNDLLMHLEPLRPLWIPVNKHGAQNA-AYARKFDEEFFGELPILTFPAGLCSRRIDGQVCDLEWKPNFLKKAYASQR 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550714308  185 PLLPVHIQAHNSLLFYASTLVSP------TVSLLLLMQQMFRRRHSQLPIKIGQQIAWNDrFSSTLSSREMAEQCRQ 255
Cdd:pfam19576 179 QIVPVFVEGELSNFFYNVARIRKalgikfNIEMLWLPDEMFSQGGKHFRIRFGEPIPMAE-LQAAGSLREQVEEVRK 254
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 77-189 1.79e-15

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 72.77  E-value: 1.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308    77 LIVIANHPTgTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLF-----IPVDNMGGRTAKASLVQMEQHLQNAGVLI 151
Cdd:smart00563   1 ALVVANHQS-FLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLrllgaIFIDRSNGRKARAALREAVELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 550714308   152 FFPAGEVSRPTRKGirdkKWHPGFIKLASKLRVPLLPV 189
Cdd:smart00563  80 IFPEGTRSRPGKLL----PFKKGAARLALEAGVPIVPV 113
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 67-191 7.05e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 49.15  E-value: 7.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308   67 DLEQIPEHGPLIVIANHPTgTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLF--IPVDNMGGRTAKASLvqmEQHL 144
Cdd:PRK08633  433 GRENIPAKGGALLLGNHVS-WIDWALLQAASPRPIRFVMERSIYEKWYLKWFFKLFgvIPISSGGSKESLEFI---RKAL 508

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 550714308  145 QNAGVLIFFPAGEVsrpTRKGIRDKkWHPGFIKLASKLRVPLLPVHI 191
Cdd:PRK08633  509 DDGEVVCIFPEGAI---TRNGQLNE-FKRGFELIVKGTDVPIIPFYI 551
 
Name Accession Description Interval E-value
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 54-257 7.50e-68

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 218.66  E-value: 7.50e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  54 LEHLDILCTISARDLEQIPEHGPLIVIANHPTGTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLFIPVDNMGGRTA 133
Cdd:cd07986    1 LDALNVQLEVDVSGLENIPKDGPVVIVANHPFGILDGLILADLLGSVRPDVRILANQLLSKIPELRDLFIPVDPLEGRAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 134 ----KASLVQMEQHLQNAGVLIFFPAGEVSR--PTRKGIRDKKWHPGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSP 207
Cdd:cd07986   81 laknRESLREALRHLKNGGALIIFPAGRVSTasPPFGRVSDRPWNPFVARLARKAKAPVVPVYFSGRNSRLFYLAGLIHP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 550714308 208 TVSLLLLMQQMFRRRHSQLPIKIGQQIAWNDrFSSTLSSREMAEQCRQHV 257
Cdd:cd07986  161 TLRTLLLPRELLNKRGKTIRIRVGRPIPPEE-LARFEDAEELADFLRLHT 209
COG3176 COG3176
Putative hemolysin [General function prediction only];
19-263 5.05e-62

Putative hemolysin [General function prediction only];


Pssm-ID: 442409  Cd Length: 270  Bit Score: 205.66  E-value: 5.05e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  19 PWQKSLLKRLLHEDEFQQFAASH----RHLKGLDMVEQVLEHLDILCTISARDLEQIPEHGPLIVIANHPTGTLDGLALL 94
Cdd:COG3176   11 RLLIRLLERLLGLGRLNRLYDQYartpAELRGAQFLRYVFEELGARLEVPEGDLDRIDADGHLLVVANHPLGILDGLALL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  95 YAVSRVRRDVKVVTNRMLSHLEP--LSSLFIPVDNMGGRTAKASLvqmeQHLQNAGVLIFFPAGEVSRptRKGIRDKKWH 172
Cdd:COG3176   91 KLVGTVRPDYRILANDLALRIPGgfYSELEFPVDPFNLETLKAAR----RHLLEGGRSCVFPAGRVSG--ARRVIDLLWS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 173 PGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSPTVSLLLLMQQMFRRRHSQLPIKIGQQIAWnDRFSSTLSSREMAEQ 252
Cdd:COG3176  165 GLAAKLARKAGAPVVPVYFDGRNSGLFYLFGSIHPTLRTAALPRELLRKRGHLIELRVGRPIPP-LELDLDLDPAELPPL 243

                        250
                 ....*....|.
gi 550714308 253 CRQHVIRLGKG 263
Cdd:COG3176  244 LRGYTYALGAD 254
Acetyltransf_5 pfam13444
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 322-423 9.31e-31

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions.


Pssm-ID: 463880  Cd Length: 102  Bit Score: 115.40  E-value: 9.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  322 LREIAFRAVEEGSGK----RRDTDSYDDDYLHLILWDDDDLEIVGAYRFMPTAMQvekCGVEGLYSYSLFHyDEKMQDIL 397
Cdd:pfam13444   1 LRYRVFREEMGATGPaalpGLDIDRFDAYCDHLLVWDDDTGEVVGTYRLLPPDAA---SGLGGFYSATEFD-LSALLALR 76

                          90       100
                  ....*....|....*....|....*.
gi 550714308  398 EHGIELGRSFIQPRYWGRRGLDYLWS 423
Cdd:pfam13444  77 GRLLELGRSCVHPEYRNGRVLLLLWA 102
Acyltransf_2 pfam19576
Acyltransferase; This family of proteins are likely to function as acyltransferases. Proteins ...
 25-255 2.42e-21

Acyltransferase; This family of proteins are likely to function as acyltransferases. Proteins in this family are found in Bacteria.


Pssm-ID: 437408  Cd Length: 266  Bit Score: 93.93  E-value: 2.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308   25 LKRLLHEDEFQQFAASHRHLKGLDMVEQVLEHLDIlcTISARDLEQIPEHGPLIVIANHPTGTLDGLALLYAVSRVRRDV 104
Cdd:pfam19576  22 LRRTIHEEDINHILANFWELPPQEFIHACFREWGI--TYSSEGLDRLDPAGRYLFVSNHPFGGMDGMMLADELIDRFGDA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  105 KVVTNRMLSHLEPLSSLFIPVDNMGGRTAkASLVQMEQHLQNAGVLIFFPAGEVSRPTRKGIRDKKWHPGFIKLASKLRV 184
Cdd:pfam19576 100 RVVVNDLLMHLEPLRPLWIPVNKHGAQNA-AYARKFDEEFFGELPILTFPAGLCSRRIDGQVCDLEWKPNFLKKAYASQR 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550714308  185 PLLPVHIQAHNSLLFYASTLVSP------TVSLLLLMQQMFRRRHSQLPIKIGQQIAWNDrFSSTLSSREMAEQCRQ 255
Cdd:pfam19576 179 QIVPVFVEGELSNFFYNVARIRKalgikfNIEMLWLPDEMFSQGGKHFRIRFGEPIPMAE-LQAAGSLREQVEEVRK 254
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 66-260 2.56e-18

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 83.91  E-value: 2.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  66 RDLEQIPEHGPLIVIANHpTGTLDGLALLYAVsrvRRDVKVVTNRMLSHLePLSSLF------IPVDNMGGRTAKASLVQ 139
Cdd:COG0204   34 EGLENLPADGPVLIVANH-QSWLDILLLLAAL---PRPVRFVAKKELFKI-PLLGWLlralgaIPVDRSKRRAALRALRQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 140 MEQHLQNAGVLIFFPAGEVSRPTRKGirdkKWHPGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSPTVSllllmqqmf 219
Cdd:COG0204  109 AVEALKAGESLVIFPEGTRSPDGRLL----PFKTGAARLALEAGVPIVPVAIDGTERALPKGFLPRPGKVT--------- 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 550714308 220 rrrhsqlpIKIGQQIAWNDRFSSTLssREMAEQCRQHVIRL 260
Cdd:COG0204  176 --------VRIGPPIDPSDLEGEDR--RELAERLRAAIEAL 206
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 62-226 6.30e-18

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 82.08  E-value: 6.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  62 TISARDLEQIPEHGPLIVIANHPTgTLDGLALLYAVSR-VRRDVKVVTNR-MLSHLEPLSSL-FIPVDNMGGRTAKASLV 138
Cdd:cd06551   13 RLEVKGPPPPPGGGPVLFVSNHSS-WWDGLILFLLLERgLRRDVYGLMDEeLLERYPFFTRLgAFSVDRDSPRSAAKSLK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 139 QMEQHLQNAG-VLIFFPAGEVSRPtrkGIRDKKWHPGFIKLASKLRVPLLPVHIQAHNS---------LLFYASTLVSPT 208
Cdd:cd06551   92 YVARLLSKPGsVVWIFPEGTRTRR---DKRPLQFKPGVAHLAEKAGVPIVPVALRYTFElfeqfpeifVRIGPPIPYAET 168

                        170
                 ....*....|....*...
gi 550714308 209 VSLLLLMQQMFRRRHSQL 226
Cdd:cd06551  169 ALGEELAAELANRLTRLL 186
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 59-254 2.57e-16

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 77.31  E-value: 2.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  59 ILCTISARDLEQIPEHGPLIVIANHPTgTLDGLALLYAVsrvRRDVKVVTNRMLSHLePLSSLF------IPVDNMGGRT 132
Cdd:cd07989    8 LGVRVRVEGLENLPPKGPVIIVANHQS-YLDPLVLGAAL---PRPIRFVAKKELFKI-PFLGWLlrllgaIPIDRGNGRS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308 133 AKASLVQMEQHLQNAGVLIFFPAGEVSRPTRKGirdkKWHPGFIKLASKLRVPLLPVHIQAHNSLLFYAStlvsptvsll 212
Cdd:cd07989   83 AREALREAIEALKEGESVVIFPEGTRSRDGELL----PFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGK---------- 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 550714308 213 llmqqmFRRRHSQLPIKIGQQIAWNDRFSSTLSSREMAEQCR 254
Cdd:cd07989  149 ------KLPRPGRVTVRIGEPIPPEGLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 77-189 1.79e-15

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 72.77  E-value: 1.79e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308    77 LIVIANHPTgTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLF-----IPVDNMGGRTAKASLVQMEQHLQNAGVLI 151
Cdd:smart00563   1 ALVVANHQS-FLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLrllgaIFIDRSNGRKARAALREAVELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 550714308   152 FFPAGEVSRPTRKGirdkKWHPGFIKLASKLRVPLLPV 189
Cdd:smart00563  80 IFPEGTRSRPGKLL----PFKKGAARLALEAGVPIVPV 113
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 66-191 6.14e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.07  E-value: 6.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308   66 RDLEQIPEHGPLIVIANHpTGTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLF-----IPVDNMGGRTAKASLVQM 140
Cdd:pfam01553   5 HGLENLPRGGPAIVVANH-QSYLDVLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMrllgcIFIDRKNRKDAAGTLEYL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 550714308  141 EQHLQNAGVLIFFPAGEVSRPTRKGirdkKWHPGFIKLASKLRVPLLPVHI 191
Cdd:pfam01553  84 VELLREGKLVVIFPEGTRSREGELL----PFKKGAFRLAIEAGVPIVPVAI 130
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 68-221 1.83e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 51.90  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  68 LEQIPEHGPLIVIANHPTGTLDGLALLYAVSRVRRDVkVVTNRMLSHLEPLSSLFIPVDNMGGRTAKASlvQMEQHLQNA 147
Cdd:cd07987   13 LENIPDEGPALLVHPHGGLPIDGALLAAAFLLLFPGR-LPRALADHFLFPLPGLRDLLRRLGAVPGSRE--NCVRLLREG 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550714308 148 GVLIFFPAG--EVSRPTRK-GIRDKKWHPGFIKLASKLRVPLLPVHIQAHNSLLFYASTLVSPTVSLLLLMQQMFRR 221
Cdd:cd07987   90 ELVLIFPGGarEALKSKREeYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLGDPDGPVGKRLFRLLPLPRR 166
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 67-191 7.05e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 49.15  E-value: 7.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308   67 DLEQIPEHGPLIVIANHPTgTLDGLALLYAVSRVRRDVKVVTNRMLSHLEPLSSLF--IPVDNMGGRTAKASLvqmEQHL 144
Cdd:PRK08633  433 GRENIPAKGGALLLGNHVS-WIDWALLQAASPRPIRFVMERSIYEKWYLKWFFKLFgvIPISSGGSKESLEFI---RKAL 508

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 550714308  145 QNAGVLIFFPAGEVsrpTRKGIRDKkWHPGFIKLASKLRVPLLPVHI 191
Cdd:PRK08633  509 DDGEVVCIFPEGAI---TRNGQLNE-FKRGFELIVKGTDVPIIPFYI 551
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 68-189 5.41e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 41.48  E-value: 5.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714308  68 LEQIPEHGPLIVIANHPTGTLDGLALLYAVSR-VRRdvkVVTNRMLSHlePLSSLF------IPV----DNMGGRTAKAS 136
Cdd:cd07992   21 RENVPKDGPVIFLGNHPNALIDPLLLAATLRRpVRF---LAKADLFKN--PLIGWLlesfgaIPVyrpkDLARGGIGKIS 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550714308 137 LVQME----QHLQNAGVLIFFPAGEV-SRPTRKGIRdkkwhPGFIKLAS------KLRVPLLPV 189
Cdd:cd07992   96 NAAVFdavgEALKAGGAIGIFPEGGShDRPRLLPLK-----AGAARMALealeagQKDVKIVPV 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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