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Conserved domains on  [gi|548244762|ref|WP_022462702|]
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MULTISPECIES: sensor histidine kinase [Lachnospiraceae]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
259-595 2.99e-79

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 258.02  E-value: 2.99e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 259 SQQSAVIDRKNVAIVLRKVDKLNGMFVTLTNLDDATGNMIKQQQRMLLEFAGFGLLLIVVVNLIVRGLLKEFYDVLCEMR 338
Cdd:COG2972  114 LLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMK 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 339 QIDNGTTKIKVCYSAEEMREMSYGINGMLERIQKQNEESIKREAALKDTAIRAMQNQINAHFIYNVLESIKMMAEINEEY 418
Cdd:COG2972  194 KVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPE 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 419 TISDAVTALGEMLHYNMRWNKFLVTVQDEMNYIQNYVELMNLRYDFTITLSVQIPENLYRQDIPKMSLQPIVENAITHGI 498
Cdd:COG2972  274 EAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGI 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 499 EELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAILRRKLrmrlnSDTQPKHGIGLRNVQDRIHIQFGTEYGLSVYT 578
Cdd:COG2972  354 EPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGEEYGLEIES 428

                        330
                 ....*....|....*..
gi 548244762 579 KEHCYTKVSIHLPITRG 595
Cdd:COG2972  429 EPGEGTTVTIRIPLEEE 445
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
259-595 2.99e-79

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 258.02  E-value: 2.99e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 259 SQQSAVIDRKNVAIVLRKVDKLNGMFVTLTNLDDATGNMIKQQQRMLLEFAGFGLLLIVVVNLIVRGLLKEFYDVLCEMR 338
Cdd:COG2972  114 LLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMK 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 339 QIDNGTTKIKVCYSAEEMREMSYGINGMLERIQKQNEESIKREAALKDTAIRAMQNQINAHFIYNVLESIKMMAEINEEY 418
Cdd:COG2972  194 KVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPE 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 419 TISDAVTALGEMLHYNMRWNKFLVTVQDEMNYIQNYVELMNLRYDFTITLSVQIPENLYRQDIPKMSLQPIVENAITHGI 498
Cdd:COG2972  274 EAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGI 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 499 EELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAILRRKLrmrlnSDTQPKHGIGLRNVQDRIHIQFGTEYGLSVYT 578
Cdd:COG2972  354 EPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGEEYGLEIES 428

                        330
                 ....*....|....*..
gi 548244762 579 KEHCYTKVSIHLPITRG 595
Cdd:COG2972  429 EPGEGTTVTIRIPLEEE 445
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 389-463 4.89e-23

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 92.89  E-value: 4.89e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548244762  389 IRAMQNQINAHFIYNVLESIKMMAEINEEyTISDAVTALGEMLHYNMRWNKFLVTVQDEMNYIQNYVELMNLRYD 463
Cdd:pfam06580   3 LKALQAQINPHFLFNTLNSISSLAIEDPE-EAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFG 76
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 481-591 1.36e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 89.81  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 481 IPKMSLQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAILRRKlrmrlnsdTQPKHGIGLRNV 560
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGKK--------PKEGNGIGLYNV 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 548244762 561 QDRIHIQFGTEYGLSVYTKEHCYTKVSIHLP 591
Cdd:cd16924   73 HQRLILLFGEDYGIHIASEPDKGTRITFTIP 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 486-593 5.55e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 65.36  E-value: 5.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762   486 LQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLA-ILRRKLRMRLNSDTQPKHGIGLRNVQDRI 564
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEkIFEPFFRTDKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*....
gi 548244762   565 HIQFGTeygLSVYTKEHCYTKVSIHLPIT 593
Cdd:smart00387  86 ELHGGE---ISVESEPGGGTTFTITLPLE 111
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 466-537 5.15e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 43.30  E-value: 5.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548244762 466 ITLSVQ--IPENLYrQDipKMSLQPIVENAITHGI---EELDADAVIEIKGIEHEK-SFEIEITDSGIGMSEKQLAIL 537
Cdd:PRK11107 390 LTLNIDpdVPDNVI-GD--PLRLQQIITNLVGNAIkftESGNIDILVELRALSNTKvQLEVQIRDTGIGISERQQSQL 464
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
259-595 2.99e-79

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 258.02  E-value: 2.99e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 259 SQQSAVIDRKNVAIVLRKVDKLNGMFVTLTNLDDATGNMIKQQQRMLLEFAGFGLLLIVVVNLIVRGLLKEFYDVLCEMR 338
Cdd:COG2972  114 LLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMK 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 339 QIDNGTTKIKVCYSAEEMREMSYGINGMLERIQKQNEESIKREAALKDTAIRAMQNQINAHFIYNVLESIKMMAEINEEY 418
Cdd:COG2972  194 KVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAELKALQAQINPHFLFNTLNSIRWLAELEDPE 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 419 TISDAVTALGEMLHYNMRWNKFLVTVQDEMNYIQNYVELMNLRYDFTITLSVQIPENLYRQDIPKMSLQPIVENAITHGI 498
Cdd:COG2972  274 EAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLIPKLILQPLVENAIEHGI 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 499 EELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAILRRKLrmrlnSDTQPKHGIGLRNVQDRIHIQFGTEYGLSVYT 578
Cdd:COG2972  354 EPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGEEYGLEIES 428

                        330
                 ....*....|....*..
gi 548244762 579 KEHCYTKVSIHLPITRG 595
Cdd:COG2972  429 EPGEGTTVTIRIPLEEE 445
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
366-594 8.55e-47

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 168.51  E-value: 8.55e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 366 MLERIQKQNEESIKREAALKDTAIRAMQNQINAHFIYNVLESIKMMAEINEEyTISDAVTALGEMLHYNMRWNKF-LVTV 444
Cdd:COG3275  138 LLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDPE-KARELLLKLSDLLRYSLYESDKeLVPL 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 445 QDEMNYIQNYVELMNLRYDFTITLSVQIPENLYRQDIPKMSLQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITD 524
Cdd:COG3275  217 EEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVEN 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 525 SGIGMSEKQlailrrklrmrlnsdTQPKHGIGLRNVQDRIHIQFGTEYGLSVYTKEHCYTKVSIHLPITR 594
Cdd:COG3275  297 NGVGIQPKK---------------KKKGSGIGLKNVRERLELLYGDKYSLEIESTDGGGTKVTLKIPLKK 351
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 389-463 4.89e-23

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 92.89  E-value: 4.89e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548244762  389 IRAMQNQINAHFIYNVLESIKMMAEINEEyTISDAVTALGEMLHYNMRWNKFLVTVQDEMNYIQNYVELMNLRYD 463
Cdd:pfam06580   3 LKALQAQINPHFLFNTLNSISSLAIEDPE-EAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFG 76
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 481-591 1.36e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 89.81  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 481 IPKMSLQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAILRRKlrmrlnsdTQPKHGIGLRNV 560
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGKK--------PKEGNGIGLYNV 72

                         90       100       110
                 ....*....|....*....|....*....|.
gi 548244762 561 QDRIHIQFGTEYGLSVYTKEHCYTKVSIHLP 591
Cdd:cd16924   73 HQRLILLFGEDYGIHIASEPDKGTRITFTIP 103
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 481-591 1.21e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 78.63  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 481 IPKMSLQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSekqlAILRRKLRMRLNSdtqpkhGIGLRNV 560
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMD----PDTLARILIRSSN------GLGLNLV 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 548244762 561 QDRIHIQFGTEYGLSVYTKEHCYTKVSIHLP 591
Cdd:cd16956   71 DKRLRQAFGNDYGLDIECAPGEGTRITIRLP 101
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 481-591 3.40e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 74.42  E-value: 3.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 481 IPKMSLQPIVENAITHGIEELDADAVIEIKGIEHEKS-FEIEITDSGIGMSEKQLAilrrklrmRLNSDTQPKHGIGLRN 559
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKQLKNrLHIAVEDNGIGISPKVIE--------RVEQDEMPGNKIGLLN 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 548244762 560 VQDRIHIqfGTEYGLSVYTKEHCYTKVSIHLP 591
Cdd:cd16955   73 VHQRLKL--GYGEGLHIRSRPDPGTLIAFYIP 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 486-593 5.55e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 65.36  E-value: 5.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762   486 LQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLA-ILRRKLRMRLNSDTQPKHGIGLRNVQDRI 564
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEkIFEPFFRTDKRSRKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*....
gi 548244762   565 HIQFGTeygLSVYTKEHCYTKVSIHLPIT 593
Cdd:smart00387  86 ELHGGE---ISVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 486-594 2.44e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 60.84  E-value: 2.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762  486 LQPIVENAITHGIEELDADAVIEIKgIEHEKSFEIEITDSGIGMSEKQLAILRRKLrMRLNSDTQPKHGIGLRNVQDRIH 565
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPF-STADKRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....*....
gi 548244762  566 IQFGTeygLSVYTKEHCYTKVSIHLPITR 594
Cdd:pfam02518  84 LLGGT---ITVESEPGGGTTVTLTLPLAQ 109
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
451-594 4.90e-07

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 51.06  E-value: 4.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 451 IQNYVELMNLRY-DFTITLSVQIPENLYRQDIPKMSLQPIV----ENAITHGieelDADAVIEIKGIEHEKSFEIEITDS 525
Cdd:COG2205   97 LEEAVEELRPLAeEKGIRLELDLPPELPLVYADPELLEQVLanllDNAIKYS----PPGGTITISARREGDGVRISVSDN 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548244762 526 GIGMSEKQLAILRRKLRMRLNSDTQPKHGIGLRNVQDRIHIQFGTeygLSVYTKEHCYTKVSIHLPITR 594
Cdd:COG2205  173 GPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGT---IWVESEPGGGTTFTVTLPLAE 238
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 481-591 2.55e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 46.26  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 481 IPKMSLQPIVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAILRRKlrmrlnsDTQPKHGIG--LR 558
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKT-------TVTSEKGTGtaLE 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 548244762 559 NVQDRIHIQFGTEYGLSVYTKEHCYTKVSIHLP 591
Cdd:cd16957   74 NLNRRLIGLFGSEACLHIESEVHGGTEVWFVIP 106
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
362-593 5.44e-06

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 48.75  E-value: 5.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 362 GINGMLERIQKQNEESIKREAALKDTAIRAMQNQINAHFIYNVLESIKMMAEInEEYTISDAVTALGEMLHYNMRWNKfl 441
Cdd:COG0642  127 AIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEP-EPVDLAELLEEVVELFRPLAEEKG-- 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 442 vtvqdemnyiqnyvelmnlrydftITLSVQIPENLYRQDIPKMSLQPI----VENAITHGieelDADAVIEIKGIEHEKS 517
Cdd:COG0642  204 ------------------------IELELDLPDDLPTVRGDPDRLRQVllnlLSNAIKYT----PEGGTVTVSVRREGDR 255

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548244762 518 FEIEITDSGIGMSEKQLAILRRKLRMRLNSDTQPKHGIGL---RNVQDRIHIQfgteygLSVYTKEHCYTKVSIHLPIT 593
Cdd:COG0642  256 VRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLaivKRIVELHGGT------IEVESEPGKGTTFTVTLPLA 328
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 489-594 6.80e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 48.69  E-value: 6.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 489 IVENAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLA-ILRRKLRmrlnSDTQPKHGIGLRNVQDRIHIQ 567
Cdd:COG3290  289 LLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEkIFERGFS----TKLGEGRGLGLALVKQIVEKY 364

                         90       100
                 ....*....|....*....|....*..
gi 548244762 568 FGTeygLSVYTKEHCYTKVSIHLPITR 594
Cdd:COG3290  365 GGT---IEVESEEGEGTVFTVRLPKEG 388
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 466-537 5.15e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 43.30  E-value: 5.15e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548244762 466 ITLSVQ--IPENLYrQDipKMSLQPIVENAITHGI---EELDADAVIEIKGIEHEK-SFEIEITDSGIGMSEKQLAIL 537
Cdd:PRK11107 390 LTLNIDpdVPDNVI-GD--PLRLQQIITNLVGNAIkftESGNIDILVELRALSNTKvQLEVQIRDTGIGISERQQSQL 464
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
451-594 1.99e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 40.37  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 451 IQNYVELMNLRYDFTITLSVQIPE---------NLYRqdipkmSLQPIVENAITHGieelDADAV-IEIkgIEHEKSFEI 520
Cdd:COG4585  129 LEELAERLLRAAGIRVELDVDGDPdrlppevelALYR------IVQEALTNALKHA----GATRVtVTL--EVDDGELTL 196

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 548244762 521 EITDSGIGMSEkqlailrrklrmrlnsDTQPKHGIGLRNVQDRIHIQFGTeygLSVYTKEHCYTKVSIHLPITR 594
Cdd:COG4585  197 TVRDDGVGFDP----------------EAAPGGGLGLRGMRERAEALGGT---LTIGSAPGGGTRVRATLPLAA 251
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
489-535 4.29e-03

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 39.92  E-value: 4.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 548244762 489 IVENAITHGieelDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLA 535
Cdd:COG5002  289 LLDNAIKYT----PEGGTITVSLREEDDQVRISVRDTGIGIPEEDLP 331
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 486-564 6.62e-03

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 39.38  E-value: 6.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548244762 486 LQPIVENAITHGIEelDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLAilrrklRM-----RLNSDTQ-PKHGIGLRN 559
Cdd:COG4251  399 FQNLISNAIKYSRP--GEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAE------KIfeifqRLHSRDEyEGTGIGLAI 470


                 ....*
gi 548244762 560 VQdRI 564
Cdd:COG4251  471 VK-KI 474
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 466-535 8.35e-03

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 39.08  E-value: 8.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 548244762 466 ITLSVQIPENLY-RQDIPKMSlQPIVeNAITHGIEELDADAVIEIKGIEHEKSFEIEITDSGIGMSEKQLA 535
Cdd:COG5806  293 VEIQTELEPGLYiEGDRQKLQ-QCLI-NIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLE 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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